Peripheral inflammation triggering central anxiety through the hippocampal glutamate metabolized receptor 1
CONCLUSION: Our work suggests that the hippocampus plays an important role in brain anxiety caused by peripheral inflammation, and over-excitation of hippocampal glutamate synapses by GRM1 activation induces anxiety-like behavior in colitis mice. These findings provide new insights into the central mechanisms underlying anxiety in UC and may contribute to the development of novel therapeutic strategies for UC-associated anxiety.PMID:38676295 | PMC:PMC11053250 | DOI:10.1111/cns.14723
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Jun-Meng Wang Yue-Mei Wang Yuan-Bing Zhu Chan Cui Tong Feng Qin Huang Shu-Qing Liu Qiao-Feng Wu Source Type: research
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