Cardiac resynchronization therapy with a defibrillator (CRTd) in failing heart patients with type 2 diabetes mellitus and treated by glucagon-like peptide 1 receptor agonists (GLP-1 RA) therapy vs. conventional hypoglycemic drugs: arrhythmic burden, hospitalizations for heart failure, and CRTd responders rate
To evaluate clinical outcomes in patients with diabetes, treated by cardiac resynchronization therapy with a defibrillator (CRT-d), and glucagon-like peptide 1 receptor agonists (GLP-1 RA) in addition to conve... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 22, 2018 Category: Cardiology Authors: Celestino Sardu, Pasquale Paolisso, Cosimo Sacra, Matteo Santamaria, Claudio de Lucia, Antonio Ruocco, Ciro Mauro, Giuseppe Paolisso, Maria Rosaria Rizzo, Michelangela Barbieri and Raffaele Marfella Tags: Original investigation Source Type: research

Hyperglycemia and risk of ventricular tachycardia among patients hospitalized with acute myocardial infarction
Little is known about the association of hyperglycemia with the development of ventricular tachycardia (VT) in patients hospitalized with acute myocardial infarction (AMI) which we examined in the present stud... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 19, 2018 Category: Cardiology Authors: Hoang V. Tran, Joel M. Gore, Chad E. Darling, Arlene S. Ash, Catarina I. Kiefe and Robert J. Goldberg Tags: Original investigation Source Type: research

Impact of type 2 diabetes mellitus in the utilization and in-hospital outcomes of surgical aortic valve replacement in Spain (2001 –2015)
The aims of this study were to examine trends in the incidence and in-hospital outcomes of SAVR among T2DM patients from 2001 to 2015, to compare clinical variables among T2DM patients and matched non-T2DM pat... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 16, 2018 Category: Cardiology Authors: Ana L ópez-de-Andrés, Napoleon Perez-Farinos, Javier de Miguel-Díez, Valentín Hernández-Barrera, Manuel Méndez-Bailón, José M. de Miguel-Yanes and Rodrigo Jiménez-García Tags: Original investigation Source Type: research

Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword
Perivascular adipose tissue (PVAT), the adipose tissue that surrounds most of the vasculature, has emerged as an active component of the blood vessel wall regulating vascular homeostasis and affecting the path... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 10, 2018 Category: Cardiology Authors: Xiao-Yan Qi, Shun-Lin Qu, Wen-Hao Xiong, Oren Rom, Lin Chang and Zhi-Sheng Jiang Tags: Review Source Type: research

Rising plasminogen activator inhibitor-1 and hypoadiponectinemia characterize the cardiometabolic biomarker profile of women with recent gestational diabetes
Gestational diabetes (GDM) and milder gestational impaired glucose tolerance (GIGT) identify women at risk of developing type 2 diabetes and cardiovascular disease later in life. Accordingly, the postpartum ye... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 9, 2018 Category: Cardiology Authors: Sadia Mehmood, Chang Ye, Philip W. Connelly, Anthony J. Hanley, Bernard Zinman and Ravi Retnakaran Tags: Original investigation Source Type: research

Impact of dapagliflozin on left ventricular diastolic function of patients with type 2 diabetic mellitus with chronic heart failure
The objective of this study was to investigate the impact of sodium glucose cotransporter type 2 (SGLT2) inhibitors on left ventricular (LV) diastolic function of type 2 diabetes mellitus (T2DM) patients with ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 8, 2018 Category: Cardiology Authors: Fumitaka Soga, Hidekazu Tanaka, Kazuhiro Tatsumi, Yasuhide Mochizuki, Hiroyuki Sano, Hiromi Toki, Kensuke Matsumoto, Junya Shite, Hideyuki Takaoka, Tomofumi Doi and Ken-ichi Hirata Tags: Original investigation Source Type: research

Impaired glucose metabolism is associated with increased thrombin generation potential in patients undergoing angioplasty and stenting
As a strong platelet agonist on the one hand and key molecule in plasmatic coagulation on the other hand, thrombin connects primary and secondary hemostasis. Thrombin generation potential reflects the individu... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 29, 2018 Category: Cardiology Authors: Silvia Lee, Cihan Ay, Christoph W. Kopp, Simon Panzer and Thomas Gremmel Tags: Original investigation Source Type: research

Effects of oral antidiabetic drugs on left ventricular mass in patients with type 2 diabetes mellitus: a network meta-analysis
We used a network meta-analysis of randomized controlled trials (RCTs) to comparatively examine the effects of oral antidiabetic drugs (OADs) on left ventricular mass (LVM) in patients with type 2 diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 27, 2018 Category: Cardiology Authors: Satoshi Ida, Ryutaro Kaneko and Kazuya Murata Tags: Original investigation Source Type: research

Both pre-frailty and frailty increase healthcare utilization and adverse health outcomes in patients with type 2 diabetes mellitus
Diabetes mellitus (DM) correlates with accelerated aging and earlier appearance of geriatric phenotypes, including frailty. However, whether pre-frailty or frailty predicts greater healthcare utilization in di... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 27, 2018 Category: Cardiology Authors: Chia-Ter Chao, Jui Wang and Kuo-Liong Chien Tags: Original investigation Source Type: research

Early vascular parameters in the micro- and macrocirculation in type 2 diabetes
Diabetes converts from a metabolic disorder into a predominantly vascular disease, once its duration extends over several years or/and when additional cardiovascular risk factors such as hypertension coexist. ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 19, 2018 Category: Cardiology Authors: Dennis Kannenkeril, Agnes Bosch, Joanna Harazny, Marina Karg, Susanne Jung, Christian Ott and Roland E. Schmieder Tags: Original investigation Source Type: research

ACE2 polymorphisms associated with cardiovascular risk in Uygurs with type 2 diabetes mellitus
Type 2 diabetes mellitus (T2D), rapidly increasing to epidemic proportions, globally escalates cardiovascular disease risk. Although intensive interventions and comprehensive management of environmental risks ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 18, 2018 Category: Cardiology Authors: Cheng Liu, Yanfang Li, Tianwang Guan, Yanxian Lai, Yan Shen, Abudurexiti Zeyaweiding, Haiyan Zhao, Fang Li and Tutiguli Maimaiti Tags: Original investigation Source Type: research

The role of physical activity in the development of first cardiovascular disease event: a tree-structured survival analysis of the Danish ADDITION-PRO cohort
We examined the interplay between PA dimensions and more conventional CVD risk factors to ass... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 12, 2018 Category: Cardiology Authors: Hanan Amadid, Nanna B. Johansen, Anne-Louise Bjerregaard, S øren Brage, Kristine Færch, Torsten Lauritzen, Daniel R. Witte, Annelli Sandbæk, Marit E. Jørgensen and Dorte Vistisen Tags: Original investigation Source Type: research

Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias
The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 10, 2018 Category: Cardiology Authors: Kathrin Weidner, Michael Behnes, Tobias Schupp, Jonas Rusnak, Linda Reiser, Armin Bollow, Gabriel Taton, Thomas Reichelt, Dominik Ellguth, Niko Engelke, Jorge Hoppner, Ibrahim El-Battrawy, Kambis Mashayekhi, Christel Wei ß, Martin Borggrefe and Ibrahim A Tags: Original investigation Source Type: research

Midlife development of type 2 diabetes and hypertension in women by history of hypertensive disorders of pregnancy
Women with history of hypertensive disorders of pregnancy (HDP) are at increased risk of early onset cardiovascular disease and type 2 diabetes (T2D). We aimed to investigate the extent to which HDP is also as... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 10, 2018 Category: Cardiology Authors: Simon Timpka, Amanda Markovitz, Tommy Schyman, Ingrid Mogren, Abigail Fraser, Paul W. Franks and Janet W. Rich-Edwards Tags: Original investigation Source Type: research

MiR-21 protected against diabetic cardiomyopathy induced diastolic dysfunction by targeting gelsolin
Diabetes is a leading cause of mortality and morbidity across the world. Over 50% of deaths among diabetic patients are caused by cardiovascular diseases. Cardiac diastolic dysfunction is one of the key early ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 4, 2018 Category: Cardiology Authors: Beibei Dai, Huaping Li, Jiahui Fan, Yanru Zhao, Zhongwei Yin, Xiang Nie, Dao Wen Wang and Chen Chen Tags: Original investigation Source Type: research

Association between insulin resistance and the development of cardiovascular disease
For many years, cardiovascular disease (CVD) has been the leading cause of death around the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid profiles and insulin resistance. I... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 31, 2018 Category: Cardiology Authors: Valeska Ormazabal, Soumyalekshmi Nair, Omar Elfeky, Claudio Aguayo, Carlos Salomon and Felipe A. Zu ñiga Tags: Review Source Type: research

Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies
The incidence and prevalence of diabetes mellitus is rapidly increasing worldwide at an alarming rate. Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes, accounting for approximately 90 –95... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 31, 2018 Category: Cardiology Authors: Raminderjit Kaur, Manpreet Kaur and Jatinder Singh Tags: Review Source Type: research

Omega-3 polyunsaturated fatty acids supplementation in patients with diabetes and cardiovascular disease risk: does dose really matter?
There is a vast disagreement in relation to the possible beneficial effects of omega-3 polyunsaturated fatty acids (omega-3 PUFA) supplementation in patients with diabetes and cardiovascular disease. The confl... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 28, 2018 Category: Cardiology Authors: Alexander Tenenbaum and Enrique Z. Fisman Tags: Commentary Source Type: research

Metabolomic profiling implicates adiponectin as mediator of a favorable lipoprotein profile associated with NT-proBNP
The N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is an important biomarker for the diagnosis of heart failure. Apart from this and only recently recognized, NT-proBNP levels associate with hi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 28, 2018 Category: Cardiology Authors: Annette Masuch, Maik Pietzner, Martin Bahls, Kathrin Budde, Gabi Kastenm üller, Stephanie Zylla, Anna Artati, Jerzy Adamski, Henry Völzke, Marcus Dörr, Stephan B. Felix, Matthias Nauck and Nele Friedrich Tags: Original investigation Source Type: research

Development of predictive risk models for major adverse cardiovascular events among patients with type 2 diabetes mellitus using health insurance claims data
There exist several predictive risk models for cardiovascular disease (CVD), including some developed specifically for patients with type 2 diabetes mellitus (T2DM). However, the models developed for a diabeti... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 24, 2018 Category: Cardiology Authors: James B. Young, Marjolaine Gauthier-Loiselle, Robert A. Bailey, Ameur M. Manceur, Patrick Lefebvre, Morris Greenberg, Marie-H élène Lafeuille, Mei Sheng Duh, Brahim Bookhart and Carol H. Wysham Tags: Original investigation Source Type: research

Cardiovascular benefit in the limelight: shifting type 2 diabetes treatment paradigm towards early combination therapy in patients with overt cardiovascular disease
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 22, 2018 Category: Cardiology Authors: Naim Shehadeh, Itamar Raz and Afif Nakhleh Tags: Commentary Source Type: research

Glycemic variability determined with a continuous glucose monitoring system can predict prognosis after acute coronary syndrome
Impaired glucose metabolism is an established risk factor for coronary artery disease. Previous studies revealed that glycemic variability (GV) is also important for glucose metabolism in patients with acute c... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 18, 2018 Category: Cardiology Authors: Hironori Takahashi, Noriaki Iwahashi, Jin Kirigaya, Shunsuke Kataoka, Yugo Minamimoto, Masaomi Gohbara, Takeru Abe, Kozo Okada, Yasushi Matsuzawa, Masaaki Konishi, Nobuhiko Maejima, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Kouichi Tamura and Kazuo Kim Tags: Original investigation Source Type: research

Correction to: Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’
Unfortunately, after publication of this article [1], it was noticed that Table 1 contained errors introduced during the production process. In the WT  + AT column, the FS value is 21 ± 7 and the Body Weight va... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 17, 2018 Category: Cardiology Authors: Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Dan Gorfil, Michal Laniado-Schwartzman, Ran Kornwoski, Dan Aravot, Nader G. Abraham, Michael Arad and Edith Hochhauser Tags: Correction Source Type: research

Biodegradable polymer drug-eluting stents versus second-generation drug-eluting stents in patients with and without diabetes mellitus: a single-center study
To improve outcomes in patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention remain an unmet clinical need. The study aimed to evaluate the efficacy and safety of G2-DESs and BP-DE... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 14, 2018 Category: Cardiology Authors: Xiao-Fang Tang, Yuan-Liang Ma, Ying Song, Jing-Jing Xu, Yi Yao, Chen He, Huan-Huan Wang, Ping Jiang, Lin Jiang, Ru Liu, Zhan Gao, Xue-yan Zhao, Shu-Bin Qiao, Yue-Jin Yang, Run-Lin Gao, Bo Xu & hellip; Tags: Original investigation Source Type: research

Overweight and obesity impair left ventricular systolic function as measured by left ventricular ejection fraction and global longitudinal strain
Obesity is associated with type 2 diabetes mellitus, left ventricular diastolic dysfunction and heart failure but it is unclear to which extent it is related to left ventricular systolic dysfunction. The aim o... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 14, 2018 Category: Cardiology Authors: Peter Blomstrand, Peter Sj öblom, Mats Nilsson, Magnus Wijkman, Martin Engvall, Toste Länne, Fredrik H. Nyström, Carl Johan Östgren and Jan Engvall Tags: Original investigation Source Type: research

Low muscle quality in Japanese type 2 diabetic patients with visceral fat accumulation
Although obesity-related type 2 diabetes mellitus (T2DM) and sarcopenia in the elderly have been increasing worldwide, the associations among visceral fat accumulation, skeletal muscle indices (mass, strength,... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 4, 2018 Category: Cardiology Authors: Jun Murai, Hitoshi Nishizawa, Akihito Otsuka, Shiro Fukuda, Yoshimitsu Tanaka, Hirofumi Nagao, Yasuna Sakai, Masahide Suzuki, Shinji Yokota, Hidetoshi Tada, Mayumi Doi, Yuya Fujishima, Shunbun Kita, Tohru Funahashi, Norikazu Maeda, Tadashi Nakamura & hell Tags: Original investigation Source Type: research

Plasma copeptin, kidney disease, and risk for cardiovascular morbidity and mortality in two cohorts of type 2 diabetes
Cardiovascular disease and kidney damage are tightly associated in people with type 2 diabetes. Experimental evidence supports a causal role for vasopressin (or antidiuretic hormone) in the development of diab... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 2, 2018 Category: Cardiology Authors: Gilberto Velho, St éphanie Ragot, Ray El Boustany, Pierre-Jean Saulnier, Mathilde Fraty, Kamel Mohammedi, Frédéric Fumeron, Louis Potier, Michel Marre, Samy Hadjadj and Ronan Roussel Tags: Original investigation Source Type: research

Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’
Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus (DM2) are all linked to diabetic cardiomyopathy that lead to heart failure. Cardiomyopathy is initially characterized by car... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 2, 2018 Category: Cardiology Authors: Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Dan Gorfil, Michal Laniado-Schwartzman, Ran Kornwoski, Dan Aravot, Nader G. Abraham, Michael Arad and Edith Hochhauser Tags: Original investigation Source Type: research

Progression of cardiovascular autonomic neuropathy and cardiovascular disease in type 2 diabetes
To examine whether the progression rate of cardiovascular autonomic neuropathy (CAN) stage is an independent predictive factor for cardiovascular disease (CVD) in type 2 diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 2, 2018 Category: Cardiology Authors: Jae-Seung Yun, Yong-Moon Park, Seon-Ah Cha, Yu-Bae Ahn and Seung-Hyun Ko Tags: Original investigation Source Type: research

Glycemic control by the SGLT2 inhibitor empagliflozin decreases aortic stiffness, renal resistivity index and kidney injury
Arterial stiffness is emerging as an independent risk factor for the development of chronic kidney disease. The sodium glucose co-transporter 2 (SGLT2) inhibitors, which lower serum glucose by inhibiting SGLT2... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 30, 2018 Category: Cardiology Authors: Annayya R. Aroor, Nitin A. Das, Andrea J. Carpenter, Javad Habibi, Guanghong Jia, Francisco I. Ramirez-Perez, Luis Martinez-Lemus, Camila M. Manrique-Acevedo, Melvin R. Hayden, Cornel Duta, Ravi Nistala, Eric Mayoux, Jaume Padilla, Bysani Chandrasekar and Tags: Original investigation Source Type: research

Dissimilar impact of type 2 diabetes on cardiovascular outcomes according to age categories: a nationwide population study from Hungary
The excess risks of mortality and cardiovascular morbidity among patients with type 2 diabetes mellitus (T2DM) is well known. In this nationwide study, we assessed risks of mortality and cardiovascular events ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 27, 2018 Category: Cardiology Authors: Zolt án Kiss, György Rokszin, Zsolt Abonyi-Tóth, György Jermendy, Péter Kempler, Dániel Aradi and István Wittmann Tags: Original investigation Source Type: research

Canagliflozin attenuates the progression of atherosclerosis and inflammation process in APOE knockout mice
Sodium glucose co-transporter2 inhibitors reduce the incidence of cardiovascular events in patients with type 2 diabetes mellitus based on the results of recent cardiovascular outcome studies. Herein, we inves... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 26, 2018 Category: Cardiology Authors: Νarjes Nasiri-Ansari, Georgios K. Dimitriadis, Georgios Agrogiannis, Despoina Perrea, Ioannis D. Kostakis, Gregory Kaltsas, Athanasios G. Papavassiliou, Harpal S. Randeva and Eva Kassi Tags: Original investigation Source Type: research

Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability
Antioxidant enzymes play a fundamental role in counteracting oxidative stress induced by high glucose. Although mitochondrial superoxide dismutase (SOD2) is the principal defence against the toxicity of supero... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 23, 2018 Category: Cardiology Authors: Lucia La Sala, Simona Mrakic-Sposta, Stefano Micheloni, Francesco Prattichizzo and Antonio Ceriello Tags: Original investigation Source Type: research

Beneficial effects of cherry consumption as a dietary intervention for metabolic, hepatic and vascular complications in type 2 diabetic rats
Oxidative stress (OS) plays an important role in type 2 diabetes (T2D) pathogenesis and its complications. New therapies target natural antioxidants as an alternative and/or supplemental strategy to prevent an... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 20, 2018 Category: Cardiology Authors: Remmelt Van der Werf, Catherine Walter, William Bietiger, Elodie Seyfritz, Carole Mura, Claude Peronet, Julie Legrandois, Dalal Werner, Said Ennahar, Fabien Digel, Elisa Maillard-Pedracini, Michel Pinget, Nathalie Jeandidier, Eric Marchioni, S éverine Si Tags: Original investigation Source Type: research

Risk of heart failure hospitalization among users of dipeptidyl peptidase-4 inhibitors compared to glucagon-like peptide-1 receptor agonists
Incretin-based therapies including dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon like peptide-1 (GLP-1) receptor agonists are novel medications for type 2 diabetes management. Several studies have fou... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 17, 2018 Category: Cardiology Authors: Ghadeer K. Dawwas, Steven M. Smith and Haesuk Park Tags: Original investigation Source Type: research

β Cell-specific deletion of guanylyl cyclase A, the receptor for atrial natriuretic peptide, accelerates obesity-induced glucose intolerance in mice
The cardiac hormones atrial (ANP) and B-type natriuretic peptides (BNP) moderate arterial blood pressure and improve energy metabolism as well as insulin sensitivity via their shared cGMP-producing guanylyl cy... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 17, 2018 Category: Cardiology Authors: Sabine Tauscher, Hitoshi Nakagawa, Katharina V ölker, Franziska Werner, Lisa Krebes, Tamara Potapenko, Sören Doose, Andreas L. Birkenfeld, Hideo A. Baba and Michaela Kuhn Tags: Original investigation Source Type: research

Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China
Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 15, 2018 Category: Cardiology Authors: Tianpeng Zheng, Bo Ge, Hongbo Liu, Bo Chen, Linyuan Qin, Liuping Xiao and Jianfei Song Tags: Original investigation Source Type: research

Potential mechanisms responsible for cardioprotective effects of sodium –glucose co-transporter 2 inhibitors
Diabetes mellitus currently affects over 350 million patients worldwide and is associated with many deaths from cardiovascular complications. Sodium –glucose co-transporter 2 (SGLT-2) inhibitors are a novel cla... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 10, 2018 Category: Cardiology Authors: Sarayut Lahnwong, Siriporn C. Chattipakorn and Nipon Chattipakorn Tags: Review Source Type: research

Visit-to-visit HbA1c variability is inversely related to baroreflex sensitivity independently of HbA1c value in type 2 diabetes
The relationship between long-term glycemic variability (GV) represented by visit-to-visit HbA1c variability and baroreflex sensitivity (BRS) in type 2 diabetes mellitus (T2DM) has not been clarified by previo... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 10, 2018 Category: Cardiology Authors: Daisuke Matsutani, Masaya Sakamoto, Soichiro Minato, Yosuke Kayama, Norihiko Takeda, Ryuzo Horiuchi and Kazunori Utsunomiya Tags: Original investigation Source Type: research

Dual inhibition of sodium –glucose linked cotransporters 1 and 2 exacerbates cardiac dysfunction following experimental myocardial infarction
Inhibiting both type 1 and 2 sodium –glucose linked cotransporter (SGLT1/2) offers the potential to not only increase glucosuria beyond that seen with selective SGLT2 inhibition alone but to reduce glucose abso... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 7, 2018 Category: Cardiology Authors: Kim A. Connelly, Yanling Zhang, Jean-Fran çois Desjardins, Kerri Thai and Richard E. Gilbert Tags: Original investigation Source Type: research

Omega-3 polyunsaturated fatty acids favourably modulate cardiometabolic biomarkers in type 2 diabetes: a meta-analysis and meta-regression of randomized controlled trials
Randomized controlled trials (RCTs) suggest that supplementation with omega-3 polyunsaturated fatty acids (n-3PUFAs) may favourably modify cardiometabolic biomarkers in type 2 diabetes (T2DM). Previous meta-an... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 7, 2018 Category: Cardiology Authors: Lauren L. O ’Mahoney, Jamie Matu, Oliver J. Price, Karen M. Birch, Ramzi A. Ajjan, Diane Farrar, Robyn Tapp, Daniel J. West, Kevin Deighton and Matthew D. Campbell Tags: Review Source Type: research

Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease
The aim of the present study was to examine the association of angiopoietin-like proteins-8 (ANGPTL8) rs2278426, cholesteryl ester-transfer protein (CETP) rs708272 and endothelial nitric oxide synthase (NOS3) rs1... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 4, 2018 Category: Cardiology Authors: Dalia El-Lebedy Tags: Original investigation Source Type: research

Prognostic impact of HbA1c variability on long-term outcomes in patients with heart failure and type 2 diabetes mellitus
The prognostic impact of long-term glycemic variability on clinical outcomes in patients with heart failure (HF) and type 2 diabetes mellitus (T2DM) remains unclear. We determined and compared hemoglobin A1c (... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 30, 2018 Category: Cardiology Authors: Jun Gu, Jian-an Pan, Yu-qi Fan, Hui-li Zhang, Jun-feng Zhang and Chang-qian Wang Tags: Original investigation Source Type: research

Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome
As body fat composition and metabolism differ between men and women, we evaluated sex-related differences in the association among epicardial adipose tissue (EAT), secretome profile, and myocardial function of... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 30, 2018 Category: Cardiology Authors: Dong-Hyuk Cho, Hyung Joon Joo, Mi-Na Kim, Do-Sun Lim, Wan Joo Shim and Seong-Mi Park Tags: Original investigation Source Type: research

Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, b... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 30, 2018 Category: Cardiology Authors: Mari ël F. van Stee, Albert A. de Graaf and Albert K. Groen Tags: Review Source Type: research

Abdominal subcutaneous adipose tissue: a favorable adipose depot for diabetes?
Previous studies have documented that visceral adipose tissue is positively associated with the risk of diabetes. However, the association of subcutaneous adipose tissue with diabetes risk is still in dispute.... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 26, 2018 Category: Cardiology Authors: Peizhu Chen, Xuhong Hou, Gang Hu, Li Wei, Lei Jiao, Hongmei Wang, Siyu Chen, Jingzhu Wu, Yuqian Bao and Weiping Jia Tags: Original investigation Source Type: research

Associations between circulating full-length angiopoietin-like protein 8 levels and severity of coronary artery disease in Chinese non-diabetic patients: a case –control study
Angiopoietin-like protein 8 (ANGPTL8), which is a novel hormone produced in liver and adipose tissue, is involved in regulating lipid metabolism. Patients with diabetes and coronary artery disease (CAD) have r... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 25, 2018 Category: Cardiology Authors: Xiaolu Jiao, Jiqiang He, Yunyun Yang, Song Yang, Juan Li and Yanwen Qin Tags: Original investigation Source Type: research

Association between sodium glucose co-transporter 2 inhibitors and a reduced risk of heart failure in patients with type 2 diabetes mellitus: a real-world nationwide population-based cohort study
Recently, two large randomized controlled trials which only included patients with underlying cardiovascular disease (CVD) or patients at high risk for CVD showed that two sodium glucose co-transporter 2 inhib... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 23, 2018 Category: Cardiology Authors: Young-Gun Kim, Seung Jin Han, Dae Jung Kim, Kwan-Woo Lee and Hae Jin Kim Tags: Original investigation Source Type: research

Non-culprit plaque characteristics in acute coronary syndrome patients with raised hemoglobinA1c: an intravascular optical coherence tomography study
Raised hemoglobinA1c (HbA1c) is an indicator of pre-diabetes, which is associated with increased risk of coronary artery disease. However, the detailed morphological characteristics of non-culprit plaques in a... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 15, 2018 Category: Cardiology Authors: Shaotao Zhang, Jiannan Dai, Haibo Jia, Sining Hu, Hongwei Du, Ning Li, Yongpeng Zou, Yanan Zou, Shenhong Jing, Yan Wang, Rong Sun and Bo Yu Tags: Original investigation Source Type: research

Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats
Calcium/calmodulin-dependent kinase II-delta (CaMKII δ) activity is enhanced during hyperglycemia and has been shown to alter intracellular calcium handling in cardiomyocytes, ultimately leading to reduced card... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 14, 2018 Category: Cardiology Authors: Lorna J. Daniels, Rachel S. Wallace, Olivia M. Nicholson, Genevieve A. Wilson, Fiona J. McDonald, Peter P. Jones, J. Chris Baldi, Regis R. Lamberts and Jeffrey R. Erickson Tags: Original investigation Source Type: research