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Influence of apocynin on cardiac remodeling in rats with streptozotocin-induced diabetes mellitus
Increased reactive oxygen species (ROS) generation in diabetes mellitus (DM) is an important mechanism leading to diabetic cardiomyopathy. Apocynin, a drug isolated from the herb Picrorhiza kurroa, is considered ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 17, 2018 Category: Cardiology Authors: R. Gimenes, C. Gimenes, C. M. Rosa, N. P. Xavier, D. H. S. Campos, A. A. H. Fernandes, M. D. M. Cezar, G. N. Guirado, L. U. Pagan, I. D. Chaer, D. C. Fernandes, F. R. Laurindo, A. C. Cicogna, M. P. Okoshi and K. Okoshi Tags: Original investigation Source Type: research

p66Shc gene expression in peripheral blood mononuclear cells and progression of diabetic complications
The risk of diabetic complications is modified by genetic and epigenetic factors. p66Shc drives the hyperglycaemic cell damage and its deletion prevents experimental diabetic complications. We herein tested wheth... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 17, 2018 Category: Cardiology Authors: Gian Paolo Fadini, Mattia Albiero, Benedetta Maria Bonora, Nicol Poncina, Saula Vigili de Kreutzenberg and Angelo Avogaro Tags: Original investigation Source Type: research

Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients
Haptoglobin (Hp) functions as an antioxidant by binding with haemoglobin. We investigated whether serum Hp has a causal effect on macroangiopathy via Mendelian randomization (MR) analysis with common variants ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 16, 2018 Category: Cardiology Authors: Shiyun Wang, Jie Wang, Rong Zhang, Tao Wang, Dandan Yan, Zhen He, Feng Jiang, Cheng Hu and Weiping Jia Tags: Original investigation Source Type: research

Comparison of speckle-tracking echocardiography with invasive hemodynamics for the detection of characteristic cardiac dysfunction in type-1 and type-2 diabetic rat models
Measurement of systolic and diastolic function in animal models is challenging by conventional non-invasive methods. Therefore, we aimed at comparing speckle-tracking echocardiography (STE)-derived parameters ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 16, 2018 Category: Cardiology Authors: Csaba M átyás, Attila Kovács, Balázs Tamás Németh, Attila Oláh, Szilveszter Braun, Márton Tokodi, Bálint András Barta, Kálmán Benke, Mihály Ruppert, Bálint Károly Lakatos, Béla Merkely and Tamás Radovits Tags: Original investigation Source Type: research

Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: role of GLP-1 isoforms in Glut4 receptor trafficking
The distribution of glucose and fatty-acid transporters in the heart is crucial for energy consecution and myocardial function. In this sense, the glucagon-like peptide-1 (GLP-1) enhancer, sitagliptin, improve... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 11, 2018 Category: Cardiology Authors: E. Ram írez, B. Picatoste, A. González-Bris, M. Oteo, F. Cruz, A. Caro-Vadillo, J. Egido, J. Tuñón, M. A. Morcillo and Ó. Lorenzo Tags: Original investigation Source Type: research

Increased epicardial adipose tissue thickness is a predictor of new-onset diabetes mellitus in patients with coronary artery disease treated with high-intensity statins
Statins are widely used for lipid lowering in patients with coronary artery disease (CAD), but increasing evidence indicates an association between statin use and new-onset of diabetes mellitus (NODM). Epicard... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 11, 2018 Category: Cardiology Authors: Jeehoon Kang, Young-Chan Kim, Jin Joo Park, Sehun Kim, Si-Hyuck Kang, Young Jin Cho, Yeonyee E. Yoon, Il-Young Oh, Chang-Hwan Yoon, Jung-Won Suh, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae and Dong-Ju Choi Tags: Original investigation Source Type: research

Relationship between cardiac microvascular dysfunction measured with 82Rubidium-PET and albuminuria in patients with diabetes mellitus
Albuminuria is of one the strongest predictors of cardiovascular disease (CVD) in diabetes. Diabetes is associated with cardiac microvascular dysfunction (CMD), a powerful, independent prognostic factor for ca... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 11, 2018 Category: Cardiology Authors: Louis Potier, Renata Chequer, Ronan Roussel, Kamel Mohammedi, Souad Sismail, Agn ès Hartemann, Chloé Amouyal, Michel Marre, Dominique Le Guludec and Fabien Hyafil Tags: Original investigation Source Type: research

Have dipeptidyl peptidase-4 inhibitors ameliorated the vascular complications of type 2 diabetes in large-scale trials? The potential confounding effect of stem-cell chemokines
Drugs that inhibit dipeptidyl peptidase-4 (DPP-4) are conventionally regarded as incretin-based agents that signal through the glucagon-like peptide-1 (GLP-1) receptor. However, inhibition of DPP-4 also potent... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 8, 2018 Category: Cardiology Authors: Milton Packer Tags: Review Source Type: research

Effects of 6-month treatment with the glucagon like peptide-1 analogue liraglutide on arterial stiffness, left ventricular myocardial deformation and oxidative stress in subjects with newly diagnosed type 2 diabetes
Incretin-based therapies are used in the treatment of type 2 diabetes mellitus (T2DM) and obesity. We investigated the changes in arterial stiffness and left ventricular (LV) myocardial deformation after 6-mon... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 8, 2018 Category: Cardiology Authors: Vaia Lambadiari, George Pavlidis, Foteini Kousathana, Maria Varoudi, Dimitrios Vlastos, Eirini Maratou, Dimitrios Georgiou, Ioanna Andreadou, John Parissis, Helen Triantafyllidi, John Lekakis, Efstathios Iliodromitis, George Dimitriadis and Ignatios Ikono Tags: Original investigation Source Type: research

Body mass index, type 2 diabetes, and left ventricular function
A recent study found that among individuals with a preserved left ventricular ejection fraction ≥ 55%, global longitudinal strain was significantly lower in overweight patients (i.e., body mass index ≥ 25 kg/m2) ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 4, 2018 Category: Cardiology Authors: Katrine Dina Musaeus and Manan Pareek Tags: Commentary Source Type: research

Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals
Data on the influence of glycemic status on the progression of coronary calcification, an important marker for future adverse cardiovascular events, are limited. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 4, 2018 Category: Cardiology Authors: Ki-Bum Won, Donghee Han, Ji Hyun Lee, Sang-Eun Lee, Ji Min Sung, Su-Yeon Choi, Eun Ju Chun, Sung Hak Park, Hae-Won Han, Jidong Sung, Hae Ok Jung and Hyuk-Jae Chang Tags: Original investigation Source Type: research

Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes
NG-Methylation of l-arginine (Arg) residues in certain proteins by protein arginine methyltransferases and subsequent proteolysis yields NG-monomethyl-l-arginine (MMA), NG,NG-dimethyl-l-arginine (asymmetric dimet... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 4, 2018 Category: Cardiology Authors: Dimitrios Tsikas, Alexander Bollenbach, Erik Hanff and Arslan Arinc Kayacelebi Tags: Commentary Source Type: research

Linagliptin and cardiovascular outcomes in type 2 diabetes after acute coronary syndrome or acute ischemic stroke
The cardiovascular safety and efficacy of linagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes mellitus (T2DM) after acute coronary syndrome (ACS) or acute ischemic stroke (AIS) ar... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 4, 2018 Category: Cardiology Authors: Yan-Rong Li, Sung-Sheng Tsai, Dong-Yi Chen, Szu-Tah Chen, Jui-Hung Sun, Hung-Yu Chang, Miaw-Jene Liou and Tien-Hsing Chen Tags: Original investigation Source Type: research

Increased myocardial extracellular volume assessed by cardiovascular magnetic resonance T1 mapping and its determinants in type 2 diabetes mellitus patients with normal myocardial systolic strain
Cardiac magnetic resonance (CMR) T1 mapping and tissue-tracking strain analysis are useful quantitative techniques that can characterize myocardial tissue and mechanical alterations, respectively, in patients ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 4, 2018 Category: Cardiology Authors: Yukun Cao, Wenjuan Zeng, Yue Cui, Xiangchuang Kong, Miao Wang, Jie Yu, Shan Zhang, Jing Song, Xu Yan, Andreas Greiser and Heshui Shi Tags: Original investigation Source Type: research

Dipeptidyl peptidase-4 inhibitor decreases the risk of atrial fibrillation in patients with type 2 diabetes: a nationwide cohort study in Taiwan
This study aimed to evaluate the risk of AF ass... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 19, 2017 Category: Cardiology Authors: Chia-Yu Chang, Yung-Hsin Yeh, Yi-Hsin Chan, Jia-Rou Liu, Shang-Hung Chang, Hsin-Fu Lee, Lung-Sheng Wu, Kun-Chi Yen, Chi-Tai Kuo and Lai-Chu See Tags: Original investigation Source Type: research

Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes
Attenuated increases in ventricular stroke volume during exercise are common in type 2 diabetes and contribute to reduced aerobic capacity. The purpose of this study was to determine whether impaired ventricul... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 19, 2017 Category: Cardiology Authors: Genevieve A. Wilson, Gerard T. Wilkins, Jim D. Cotter, Regis R. Lamberts, Sudish Lal and James C. Baldi Tags: Original investigation Source Type: research

Suboptimal control of lipid levels: results from the non-interventional Centralized Pan-Russian Survey of the Undertreatment of Hypercholesterolemia II (CEPHEUS II)
This study evaluated LDL-C goal attainment in Russian clini... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 16, 2017 Category: Cardiology Authors: Sergey Boytsov, Natalia Logunova and Yunona Khomitskaya Tags: Original investigation Source Type: research

Relative hyperglycemia is associated with complications following an acute myocardial infarction: a post-hoc analysis of HI-5 data
Hyperglycemia is associated with increased morbidity and mortality in patients with an acute myocardial infarction (AMI). We evaluated whether complications after AMI are associated with absolute or relative g... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 12, 2017 Category: Cardiology Authors: Tien F. Lee, Morton G. Burt, Leonie K. Heilbronn, Arduino A. Mangoni, Vincent W. Wong, Mark McLean and N. Wah Cheung Tags: Original investigation Source Type: research

Plaque volume and plaque risk profile in diabetic vs. non-diabetic patients undergoing lipid-lowering therapy: a study based on 3D intravascular ultrasound and virtual histology
Coronary atherosclerosis progresses faster in patients with diabetes mellitus (DM) and causes higher morbidity and mortality in such patients compared to non-diabetics ones (non-DM). We quantify changes in pla... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 7, 2017 Category: Cardiology Authors: Tomas Kovarnik, Zhi Chen, Gary S. Mintz, Andreas Wahle, Kristyna Bayerova, Ales Kral, Martin Chval, Karel Kopriva, John Lopez, Milan Sonka and Ales Linhart Tags: Original investigation Source Type: research

Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection
Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading cause of death in diabetes mellitus (DM). In addition to eliciting cardiomyopathy, DM induces a ‘wicked triumvirate’: (i) incr... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 4, 2017 Category: Cardiology Authors: Jake Russell, Eugene F. Du Toit, Jason N. Peart, Hemal H. Patel and John P. Headrick Tags: Review Source Type: research

Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study
This study aimed to assess the associations... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 1, 2017 Category: Cardiology Authors: Christian Stevns Hansen, Dorte Vistisen, Marit Eika J ørgensen, Daniel R. Witte, Eric J. Brunner, Adam G. Tabák, Mika Kivimäki, Michael Roden, Marek Malik and Christian Herder Tags: Original investigation Source Type: research

DPP-4 inhibition with linagliptin ameliorates the progression of premature aging in klotho −/− mice
This study was performed to determine whether linagliptin, a DPP-4 inhibitor, could protect against premature aging in klotho −/− mice. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 1, 2017 Category: Cardiology Authors: Yu Hasegawa, Kenyu Hayashi, Yushin Takemoto, Cao Cheng, Koki Takane, Bowen Lin, Yoshihiro Komohara and Shokei Kim-Mitsuyama Tags: Original investigation Source Type: research

Type 2 diabetes mellitus is associated with a lower fibrous cap thickness but has no impact on calcification morphology: an intracoronary optical coherence tomography study
Patients with type 2 diabetes (T2DM) are at high risk for cardiovascular events, which usually arise from the rupture of a vulnerable coronary plaque. The minimal fibrous cap thickness (FCT) overlying a necrot... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 1, 2017 Category: Cardiology Authors: Andrea Milzi, Mathias Burgmaier, Kathrin Burgmaier, Martin Hellmich, Nikolaus Marx and Sebastian Reith Tags: Original investigation Source Type: research

Low 1,5-anhydroglucitol levels are associated with long-term cardiac mortality in acute coronary syndrome patients with hemoglobin A1c levels less than 7.0%
Diabetes mellitus is considered an important risk factor for cardiovascular diseases. High hemoglobin A1c (HbA1c) levels, which indicate poor glycemic control, have been associated with occurrence of cardiovas... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 21, 2017 Category: Cardiology Authors: Shohei Ouchi, Kazunori Shimada, Tetsuro Miyazaki, Shuhei Takahashi, Yurina Sugita, Megumi Shimizu, Azusa Murata, Tomoyasu Kadoguchi, Takao Kato, Tatsuro Aikawa, Shoko Suda, Eiryu Sai, Masaru Hiki, Hiroshi Iwata, Takatoshi Kasai, Katsumi Miyauchi & hellip; Tags: Original investigation Source Type: research

Correction to: Updates on cardiovascular outcome trials in diabetes
Following publication of the original article [1], the authors submitted a corrected version of Table  4 (see below). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 15, 2017 Category: Cardiology Authors: Oliver Schnell, Lars Ryd én, Eberhard Standl and Antonio Ceriello Tags: Correction Source Type: research

Correction to: Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin
Following publication of the original article [1], the authors identified a number of errors. In Result (P.3), Table 1 (P.4), Table 5 (P.9) and Supplementary Table 1, the correct unit for adiponectin was μg/mL. I... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 13, 2017 Category: Cardiology Authors: Toshiyuki Hayashi, Tomoyasu Fukui, Noriko Nakanishi, Saki Yamamoto, Masako Tomoyasu, Anna Osamura, Makoto Ohara, Takeshi Yamamoto, Yasuki Ito and Tsutomu Hirano Tags: Correction Source Type: research

Transcatheter aortic valve implantation and surgical aortic valve replacement among hospitalized patients with and without type 2 diabetes mellitus in Spain (2014 –2015)
Type 2 diabetes mellitus (T2DM) is strongly related to the in-hospital and short-term prognosis in patients with cardiovascular diseases needing surgical or invasive interventions. How T2DM might influence the... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 9, 2017 Category: Cardiology Authors: Manuel Mendez-Bailon, Noel Lorenzo-Villalba, Nuria Mu ñoz-Rivas, Jose Maria de Miguel-Yanes, Javier De Miguel-Diez, Josep Comín-Colet, Valentin Hernandez-Barrera, Rodrigo Jimenez-Garcia and Ana Lopez-de-Andres Tags: Original investigation Source Type: research

Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels
Irisin is a hormone released mainly from skeletal muscle after exercise which increases adipose tissue energy expenditure. Adipocytes can also release irisin after exercise, acting as a local adipokine to indu... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 9, 2017 Category: Cardiology Authors: Karan S. Rana, Chathyan Pararasa, Islam Afzal, David A. Nagel, Eric J. Hill, Clifford J. Bailey, Helen R. Griffiths, Ioannis Kyrou, Harpal S. Randeva, Srikanth Bellary and James E. Brown Tags: Original investigation Source Type: research

Impact of overweight on left ventricular function in type 2 diabetes mellitus
Coexistence of left ventricular (LV) longitudinal myocardial systolic dysfunction with LV diastolic dysfunction could lead to heart failure with preserved ejection fraction (HFpEF). Diabetes mellitus (DM) is k... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 9, 2017 Category: Cardiology Authors: Makiko Suto, Hidekazu Tanaka, Yasuhide Mochizuki, Jun Mukai, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Sano, Hiroyuki Shimoura, Junichi Ooka, Kensuke Matsumoto, Yushi Hirota, Wataru Ogawa & helli Tags: Original investigation Source Type: research

Effects of hypoglycemia on myocardial susceptibility to ischemia –reperfusion injury and preconditioning in hearts from rats with and without type 2 diabetes
Hypoglycemia is associated with increased mortality rate in patients with diabetes. The underlying mechanisms may involve reduced myocardial tolerance to ischemia and reperfusion (IR) or reduced capacity for i... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 9, 2017 Category: Cardiology Authors: Kim B. P ælestik, Nichlas R. Jespersen, Rebekka V. Jensen, Jacob Johnsen, Hans Erik Bøtker and Steen B. Kristiansen Tags: Original investigation Source Type: research

Effect of rosuvastatin on fasting and postprandial endothelial biomarker levels and microvascular reactivity in patients with type 2 diabetes and dyslipidemia: a preliminary report
The cardiovascular benefits of statins have been proven, but their effect on circulation in small vessels has not been examined fully. We investigated the effect of 20  mg rosuvastatin on biomarkers, including ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 9, 2017 Category: Cardiology Authors: Kyoung Min Kim, Kyong Yeun Jung, Han Mi Yun, Seo Young Lee, Tae Jung Oh, Hak Chul Jang and Soo Lim Tags: Original investigation Source Type: research

Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis
Macrophages play a pivotal role in atherosclerotic plaque development. Recent evidence has suggested the glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, can attenuate pro-inflammatory responses... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 6, 2017 Category: Cardiology Authors: Robyn Bruen, Sean Curley, Sarina Kajani, Daniel Crean, Marcella E. O ’Reilly, Margaret B. Lucitt, Catherine G. Godson, Fiona C. McGillicuddy and Orina Belton Tags: Original investigation Source Type: research

Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains
We have previously shown that many chronic, inflammatory diseases are accompanied, and possibly partly caused or exacerbated, by various coagulopathies, manifested as anomalous clots in the form of ‘dense matt... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 2, 2017 Category: Cardiology Authors: Etheresia Pretorius, Martin J. Page, Lize Engelbrecht, Graham C. Ellis and Douglas B. Kell Tags: Original investigation Source Type: research

Tissue-engineered smooth muscle cell and endothelial progenitor cell bi-level cell sheets prevent progression of cardiac dysfunction, microvascular dysfunction, and interstitial fibrosis in a rodent model of type 1 diabetes-induced cardiomyopathy
Diabetes mellitus is a risk factor for coronary artery disease and diabetic cardiomyopathy, and adversely impacts outcomes following coronary artery bypass grafting. Current treatments focus on macro-revascula... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 2, 2017 Category: Cardiology Authors: Masashi Kawamura, Michael J. Paulsen, Andrew B. Goldstone, Yasuhiro Shudo, Hanjay Wang, Amanda N. Steele, Lyndsay M. Stapleton, Bryan B. Edwards, Anahita Eskandari, Vi N. Truong, Kevin J. Jaatinen, Arnar B. Ingason, Shigeru Miyagawa, Yoshiki Sawa and Y. J Tags: Original investigation Source Type: research

Pioglitazone stabilizes atherosclerotic plaque by regulating the Th17/Treg balance in AMPK-dependent mechanisms
Pioglitazone (PIO), a thiazolidinediones drug, is a well-known anti-diabetic medicine, but its anti-atherosclerotic effects remain controversial. Thus it is important to investigate the effects of PIO on ather... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 30, 2017 Category: Cardiology Authors: Yuling Tian, Tao Chen, Yan Wu, Lin Yang, Lijun Wang, Xiaojuan Fan, Wei Zhang, Jiahao Feng, Hang Yu, Yanjie Yang, Juan Zhou, Zuyi Yuan and Yue Wu Tags: Original investigation Source Type: research

Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies
Altered regulation of extracellular matrix (ECM) composition by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMPs) may contribute to arterial stiffening. We investigated associ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 25, 2017 Category: Cardiology Authors: Stijn A. Peeters, Lian Engelen, Jacqueline Buijs, Nish Chaturvedi, John H. Fuller, Anders Jorsal, Hans-Henrik Parving, Lise Tarnow, Simone Theilade, Peter Rossing, Casper G. Schalkwijk and Coen D. A. Stehouwer Tags: Original investigation Source Type: research

Translating recent results from the Cardiovascular Outcomes Trials into clinical practice: recommendations from the Central and Eastern European Diabetes Expert Group (CEEDEG)
These recommendations aim to improve care for patients with type 2 diabetes (T2D) at high cardiovascular (CV) risk in Central and Eastern Europe. Cardiovascular disease (CVD) and/or chronic kidney disease (CKD... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 23, 2017 Category: Cardiology Authors: Guntram Schernthaner, Roger Lehmann, Martin Pr ázný, Leszek Czupryniak, Kristine Ducena, Peter Fasching, Andrej Janež, Avraham Karasik, Peter Kempler, Emil Martinka, Marina V. Shestakova, Lea Smirčić Duvnjak and Tsvetalina Tankova Tags: Review Source Type: research

Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study
Sodium-glucose cotransporter-2 inhibitors reduce blood pressure (BP) and renal and cardiovascular events in patients with type 2 diabetes through not fully elucidated mechanisms. Aim of this study was to inves... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 23, 2017 Category: Cardiology Authors: Anna Solini, Livia Giannini, Marta Seghieri, Edoardo Vitolo, Stefano Taddei, Lorenzo Ghiadoni and Rosa Maria Bruno Tags: Original investigation Source Type: research

Correction to: Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C- β–dependent vascular endothelial cadherin tyrosine phosphorylation
This article was unintentionally published twice in this journal, by the same authors. The following should be considered the version of record and used for citation purposes: “Mehran Haidari, Wei Zhang, James... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 20, 2017 Category: Cardiology Authors: Mehran Haidari, Wei Zhang, James T. Willerson and Richard A. F. Dixon Tags: Correction Source Type: research

Correction to: Report from the 2nd Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes and Cardiovascular Disease (D & CVD) EASD Study Group
Following publication of the original article [1], author Antonio Ceriello requested that a correction be published in relation to his affiliations. His correct affiliations have been updated in this erratum. Thi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 18, 2017 Category: Cardiology Authors: Oliver Schnell, Eberhard Standl, Doina Catrinoiu, Stefano Genovese, Nebojsa Lalic, Jan Skra, Paul Valensi, Dario Rahelic and Antonio Ceriello Tags: Correction Source Type: research

Pioglitazone and the secondary prevention of cardiovascular disease. A meta-analysis of randomized-controlled trials
Pioglitazone targets multiple pathogenic pathways involved in the development of cardiovascular diseases (CVD). The aim of this systematic review and meta-analysis is to assess the effects of pioglitazone trea... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 16, 2017 Category: Cardiology Authors: Marit de Jong, H. Bart van der Worp, Yolanda van der Graaf, Frank L. J. Visseren and Jan Westerink Tags: Review Source Type: research

Human epicardial adipose tissue-derived and circulating secreted frizzled-related protein 4 (SFRP4) levels are increased in patients with coronary artery disease
Previous studies have demonstrated that secreted frizzled-related protein 4 (SFRP4) is associated with impaired glucose and triglyceride metabolism in patients with stable coronary artery disease. In the prese... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 16, 2017 Category: Cardiology Authors: Qingwei Ji, Jianwei Zhang, Yu Du, Enjun Zhu, Zhijian Wang, Bin Que, Huangtai Miao, Shutian Shi, Xiuchuan Qin, Yingxin Zhao, Yujie Zhou, Fangjun Huang and Shaoping Nie Tags: Original investigation Source Type: research

Increased amputation risk with canagliflozin treatment: behind the large cardiovascular benefit?
A growing body of evidence suggests that sodium-glucose cotransporter 2 (SGLT2) inhibitors appear to be a powerful option to improve the cardiovascular (CV) prognosis in high CV-risk patients with type 2 diabe... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 12, 2017 Category: Cardiology Authors: Atsushi Tanaka and Koichi Node Tags: Commentary Source Type: research

Impact of empagliflozin on subclinical left ventricular dysfunctions and on the mechanisms involved in myocardial disease progression in type 2 diabetes: rationale and design of the EMPA-HEART trial
Asymptomatic left ventricular (LV) dysfunction is highly prevalent in type 2 diabetes patients. Unlike the other hypoglycemic drugs, SGLT2 inhibitors have shown potential benefits for reducing cardiovascular d... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 12, 2017 Category: Cardiology Authors: Andrea Natali, Lorenzo Nesti, Iacopo Fabiani, Enrico Calogero and Vitantonio Di Bello Tags: Study Protocol Source Type: research

Impact of renal function on the underlying pathophysiology of coronary plaque composition in patients with type 2 diabetes mellitus
Both the progression of diabetic kidney disease and increased glycemic variability play important roles in the pathogenesis of coronary plaque formation via inflammatory pathways in patients with type 2 diabet... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 12, 2017 Category: Cardiology Authors: Kentaro Kakuta, Kaoru Dohi, Miho Miyoshi, Takashi Yamanaka, Masaki Kawamura, Jun Masuda, Tairo Kurita, Toru Ogura, Norikazu Yamada, Yasuhiro Sumida and Masaaki Ito Tags: Original investigation Source Type: research

The anti-inflammatory function of HDL is impaired in type 2 diabetes: role of hyperglycemia, paraoxonase-1 and low grade inflammation
Functional properties of high density lipoproteins (HDL) are increasingly recognized to play a physiological role in atheroprotection. Type 2 diabetes mellitus (T2DM) is characterized by low HDL cholesterol, b... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 12, 2017 Category: Cardiology Authors: Sanam Ebtehaj, Eke G. Gruppen, Mojtaba Parvizi, Uwe J. F. Tietge and Robin P. F. Dullaart Tags: Original investigation Source Type: research

Updates on cardiovascular outcome trials in diabetes
In 2008 the Food and Drug Administration introduced a guidance for industry that requires the investigation of cardiovascular outcomes of glucose-lowering medications. Since then, an increasing number of cardi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 11, 2017 Category: Cardiology Authors: Oliver Schnell, Lars Ryd én, Eberhard Standl and Antonio Ceriello Tags: Review Source Type: research

Impact of type 2 diabetes mellitus on in-hospital-mortality after major cardiovascular events in Spain (2002 –2014)
Diabetes mellitus has long been associated with cardiovascular events. Nevertheless, the higher burden of traditional cardiovascular risk factors reported in high-income countries is offset by a more widesprea... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 10, 2017 Category: Cardiology Authors: Jos é M. de Miguel-Yanes, Rodrigo Jiménez-García, Valentín Hernández-Barrera, Manuel Méndez-Bailón, Javier de Miguel-Díez and Ana Lopez-de-Andrés Tags: Original investigation Source Type: research

Glycated albumin and its variability as an indicator of cardiovascular autonomic neuropathy development in type 2 diabetic patients
We investigated whether glycated albumin (GA) and its variability are associated with cardiovascular autonomic neuropathy (CAN) and further compared their associations with glycated hemoglobin (HbA1c). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 10, 2017 Category: Cardiology Authors: Ji Eun Jun, Seung-Eun Lee, You-Bin Lee, Ji Yeon Ahn, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Moon-Kyu Lee and Jae Hyeon Kim Tags: Original investigation Source Type: research

The effects of vildagliptin compared with metformin on vascular endothelial function and metabolic parameters: a randomized, controlled trial (Sapporo Athero-Incretin Study 3)
Dipeptidyl peptidase-4 (DPP-4) inhibitors may have protective effects in the early stage of atherosclerosis in patients with type 2 diabetes, although similar effects in advanced atherosclerosis were not shown... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 10, 2017 Category: Cardiology Authors: Naoyuki Kitao, Hideaki Miyoshi, Tomoo Furumoto, Kota Ono, Hiroshi Nomoto, Aika Miya, Chiho Yamamoto, Atsushi Inoue, Kenichi Tsuchida, Naoki Manda, Yoshio Kurihara, Shin Aoki, Akinobu Nakamura and Tatsuya Atsumi Tags: Original investigation Source Type: research