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Novel risk genes identified in a genome-wide association study for coronary artery disease in patients with type 1 diabetes
Patients with type 1 diabetes are more at risk of coronary artery disease than the general population. Although evidence points to a genetic risk there have been no study investigating genetic risk factors of ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 25, 2018 Category: Cardiology Authors: Romain Charmet, Seamus Duffy, Sareh Keshavarzi, Beata Gyorgy, Michel Marre, Peter Rossing, Amy Jayne McKnight, Alexander P. Maxwell, Tarun veer Singh Ahluwalia, Andrew D. Paterson, David-Alexandre Tr égouët and Samy Hadjadj Tags: Original investigation Source Type: research

The role of dipeptidylpeptidase-4 inhibitors in management of cardiovascular disease in diabetes; focus on linagliptin
Multiple population based analyses have demonstrated a high incidence of cardiovascular disease (CVD) and cardiovascular (CV) mortality in subjects with T2DM that reduces life expectancy by as much as 15 years... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 18, 2018 Category: Cardiology Authors: Annayya R. Aroor, Camila Manrique-Acevedo and Vincent G. DeMarco Tags: Review Source Type: research

Diabetes, cardiovascular disease and the microcirculation
Cardiovascular disease (CVD) is the leading cause of mortality in people with type 2 diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be accounted for by conventional cardiov... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 18, 2018 Category: Cardiology Authors: W. David Strain and P. M. Pald ánius Tags: Review Source Type: research

Prevalence of left ventricular systolic dysfunction and heart failure with reduced ejection fraction in men and women with type 2 diabetes mellitus: a systematic review and meta-analysis
Type 2 diabetes mellitus (T2D) is associated with the development of left ventricular systolic dysfunction (LVSD) and heart failure with reduced ejection fraction (HFrEF). T2D patients with LVSD are at higher ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 18, 2018 Category: Cardiology Authors: Selma Bouthoorn, Aisha Gohar, Gideon Valstar, Hester M. den Ruijter, J. B. Reitsma, Arno W. Hoes and Frans H. Rutten Tags: Original investigation Source Type: research

Sarcopenic obesity assessed using dual energy X-ray absorptiometry (DXA) can predict cardiovascular disease in patients with type 2 diabetes: a retrospective observational study
Sarcopenic obesity, defined as reduced skeletal muscle mass and power with increased adiposity, was reported to be associated with cardiovascular disease risks in previous cross-sectional studies. Whole body d... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 10, 2018 Category: Cardiology Authors: Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Kazutaka Tsujimoto, Isao Minami, Takanobu Yoshimoto and Yoshihiro Ogawa Tags: Original investigation Source Type: research

Antidiabetic treatment patterns and specialty care utilization among patients with type 2 diabetes and cardiovascular disease
To evaluate real-world patient characteristics, medication use, and health care utilization patterns in patients with type 2 diabetes with established cardiovascular disease (CVD). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 10, 2018 Category: Cardiology Authors: Kevin M. Pantalone, Anita D. Misra-Hebert, Todd M. Hobbs, Xinge Ji, Sheldon X. Kong, Alex Milinovich, Wayne Weng, Janine Bauman, Rahul Ganguly, Bartolome Burguera, Michael W. Kattan and Robert S. Zimmerman Tags: Original investigation Source Type: research

Liraglutide suppresses non-esterified free fatty acids and soluble vascular cell adhesion molecule-1 compared with metformin in patients with recent-onset type 2 diabetes
It has been suggested that liraglutide could have an impact on glucose and lipid metabolism disorder and adhesion molecule activation, which may play important roles in the vascular damage of diabetes. In this... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 10, 2018 Category: Cardiology Authors: Xiao-min Chen, Wen-qiang Zhang, Yuan Tian, Li-fen Wang, Chan-chan Chen and Chuan-mei Qiu Tags: Original investigation Source Type: research

Empagliflozin influences blood viscosity and wall shear stress in subjects with type 2 diabetes mellitus compared with incretin-based therapy
Cardiovascular protection following empagliflozin therapy is not entirely attributable to the glucose lowering effect. Increased hematocrit might influence the shear stress that is the main force acting on the... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 9, 2018 Category: Cardiology Authors: Concetta Irace, Francesco Casciaro, Faustina Barbara Scavelli, Rosa Oliverio, Antonio Cutruzzol à, Claudio Cortese and Agostino Gnasso Tags: Original investigation Source Type: research

The effect of change in fasting glucose on the risk of myocardial infarction, stroke, and all-cause mortality: a nationwide cohort study
The effect of change in blood glucose levels on the risk of cardiovascular disease among individuals without diabetes is currently unclear. We aimed to examine the association of change in fasting serum glucos... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 7, 2018 Category: Cardiology Authors: Gyeongsil Lee, Sung Min Kim, Seulggie Choi, Kyuwoong Kim, Su-Min Jeong, Joung Sik Son, Jae-Moon Yun and Sang Min Park Tags: Original investigation Source Type: research

Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria
The urinary proteomic classifier CKD273 has shown promise for prediction of progressive diabetic nephropathy (DN). Whether it is also a determinant of mortality and cardiovascular disease in patients with micr... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 6, 2018 Category: Cardiology Authors: Gemma E. Currie, Bernt Johan von Scholten, Sheon Mary, Jose-Luis Flores Guerrero, Morten Lindhardt, Henrik Reinhard, Peter K. Jacobsen, William Mullen, Hans-Henrik Parving, Harald Mischak, Peter Rossing and Christian Delles Tags: Original investigation Source Type: research

Correction to: Type 2 diabetes-associated carotid plaque burden is increased in patients with retinopathy compared to those without retinopathy
The author found errors in Table 1 after publication of the original article [1]. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 5, 2018 Category: Cardiology Authors: N úria Alonso, Alicia Traveset, Esther Rubinat, Emilio Ortega, Nuria Alcubierre, Jordi Sanahuja, Marta Hernández, Angels Betriu, Carmen Jurjo, Elvira Fernández and Didac Mauricio Tags: Correction Source Type: research

Liraglutide downregulates hepatic LDL receptor and PCSK9 expression in HepG2 cells and db/db mice through a HNF-1a dependent mechanism
Proprotein convertase subtilisin/kexin type 9 (PCSK9), a major regulator of cholesterol homeostasis, is associated with glucose metabolism. Liraglutide, a glucagon-like peptide-1 receptor agonist, can increase... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 4, 2018 Category: Cardiology Authors: Sheng-Hua Yang, Rui-Xia Xu, Chuan-Jue Cui, Yin Wang, Ying Du, Zhi-Guo Chen, Yu-Hong Yao, Chun-Yan Ma, Cheng-Gang Zhu, Yuan-Lin Guo, Na-Qiong Wu, Jing Sun, Bu-Xing Chen and Jian-Jun Li Tags: Original investigation Source Type: research

The role of obesity in carotid plaque instability: interaction with age, gender, and cardiovascular risk factors
In the last decade, several studies have reported an unexpected and seemingly paradoxical inverse correlation between BMI and incidence of cardiovascular diseases. This so called “obesity paradox effect” has b... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 29, 2018 Category: Cardiology Authors: Valentina Rovella, Lucia Anemona, Marina Cardellini, Manuel Scimeca, Andrea Saggini, Giuseppe Santeusanio, Elena Bonanno, Manuela Montanaro, Iacopo Maria Legramante, Arnaldo Ippoliti, Nicola Di Daniele, Massimo Federici and Alessandro Mauriello Tags: Original investigation Source Type: research

HbA1c variability and diabetic peripheral neuropathy in type 2 diabetic patients
Diabetic complications may be associated with impaired time-dependent glycemic control. Therefore, long-term glycemic variability, assessed by variations in haemoglobin A1c (HbA1c), may be a potential risk fac... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 29, 2018 Category: Cardiology Authors: Jian-bin Su, Li-hua Zhao, Xiu-lin Zhang, Hong-li Cai, Hai-yan Huang, Feng Xu, Tong Chen and Xue-qin Wang Tags: Original investigation Source Type: research

Bone markers and cardiovascular risk in type 2 diabetes patients
Vascular calcifications are associated with a three- to fourfold increased risk of cardiovascular disease (CVD) and are highly prevalent in type 2 diabetes patients. Emerging evidence indicates that vascular c... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 23, 2018 Category: Cardiology Authors: Sabine R. Zwakenberg, Yvonne T. van der Schouw, Casper G. Schalkwijk, Annemieke M. W. Spijkerman and Joline W. J. Beulens Tags: Original investigation Source Type: research

Exercise capacity in diabetes mellitus is predicted by activity status and cardiac size rather than cardiac function: a case control study
The reasons for reduced exercise capacity in diabetes mellitus (DM) remains incompletely understood, although diastolic dysfunction and diabetic cardiomyopathy are often favored explanations. However, there is... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 23, 2018 Category: Cardiology Authors: Timothy J. Roberts, Andrew T. Burns, Richard J. MacIsaac, Andrew I. MacIsaac, David L. Prior and Andr é La Gerche Tags: Original investigation Source Type: research

Correction to: HbA1c versus oral glucose tolerance test as a method to diagnose diabetes mellitus in vascular surgery patients
The authors found errors in Table 1 after publication of the original article [1]. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 22, 2018 Category: Cardiology Authors: Iren D. Hjellestad, Marianne C. Astor, Roy M. Nilsen, Eirik S øfteland and Torbjørn Jonung Tags: Correction Source Type: research

Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides
Diabetic cardiomyopathy (DCM) is a chronic complication in individuals with diabetes and is characterized by ventricular dilation and hypertrophy, diastolic dysfunction, decreased or preserved systolic functio... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 22, 2018 Category: Cardiology Authors: Nilanjan Ghosh and Rajesh Katare Tags: Review Source Type: research

Association between triglyceride glucose index and arterial stiffness in Korean adults
The triglyceride glucose (TyG) index has been suggested as a simple surrogate marker of insulin resistance. However, there are limited data regarding the association between the TyG index and arterial stiffnes... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 21, 2018 Category: Cardiology Authors: Sang Bae Lee, Chul Woo Ahn, Byoung Kwon Lee, Shinae Kang, Ji Sun Nam, Ji Hong You, Min Jin Kim, Min Kyung Kim and Jong Suk Park Tags: Original investigation Source Type: research

Relationships between epicardial adipose tissue thickness and adipo-fibrokine indicator profiles post-myocardial infarction
Determination of the impact of visceral obesity and epicardial adipose tissue thickness on stimulating growth factor levels during hospitalization for myocardial infarction is of potential importance for predi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 16, 2018 Category: Cardiology Authors: Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Daria Borodkina, Olga Akbasheva, Ekaterina Belik, Viktoria Karetnikova, Natalia Brel, Alexander Kokov, Vasiliy Kashtalap and Olga Barbarash Tags: Original investigation Source Type: research

Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA ®): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk
Cardiovascular (CV) outcome trials in type 2 diabetes (T2D) have underrepresented patients with chronic kidney disease (CKD), leading to uncertainty regarding their kidney efficacy and safety. The CARMELINA ® tria... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 14, 2018 Category: Cardiology Authors: Julio Rosenstock, Vlado Perkovic, John H. Alexander, Mark E. Cooper, Nikolaus Marx, Michael J. Pencina, Robert D. Toto, Christoph Wanner, Bernard Zinman, David Baanstra, Egon Pfarr, Michaela Mattheus, Uli C. Broedl, Hans-Juergen Woerle, Jyothis T. George, Tags: Original investigation Source Type: research

Correction to: SGLT2 inhibitors: a novel choice for the combination therapy in diabetic kidney disease
Following publication of the original article [1] the authors reported that the first affiliation ( “Medical Center of the Graduate School, Nanchang University, China”) had been added in error, and that the cor... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 9, 2018 Category: Cardiology Authors: Honghong Zou, Baoqin Zhou and Gaosi Xu Tags: Correction Source Type: research

Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is associated with obesity and low grade inflammation and the risk for cardiovascular disease (CVD) could be increased in PCOS. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 8, 2018 Category: Cardiology Authors: Dorte Glintborg, Katrine Hass Rubin, Mads Nybo, Bo Abrahamsen and Marianne Andersen Tags: Original investigation Source Type: research

Glycemic variability in continuous glucose monitoring is inversely associated with baroreflex sensitivity in type 2 diabetes: a preliminary report
It is presently unclear whether glycemic variability (GV) is associated with baroreflex sensitivity (BRS), which is an early indicator of cardiovascular autonomic neuropathy. The present study is the first to ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 7, 2018 Category: Cardiology Authors: Daisuke Matsutani, Masaya Sakamoto, Hiroyuki Iuchi, Souichirou Minato, Hirofumi Suzuki, Yosuke Kayama, Norihiko Takeda, Ryuzo Horiuchi and Kazunori Utsunomiya Tags: Original investigation Source Type: research

Cardiovascular magnetic resonance measures of aortic stiffness in asymptomatic patients with type 2 diabetes: association with glycaemic control and clinical outcomes
We aimed to investigate in patients with type 2 diabetes whether aortic stiffness is: (i) associated with glycaemic control, (ii) associated with adverse outcomes and (iii) can be reversed on treatment with RA... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 5, 2018 Category: Cardiology Authors: Peter P. Swoboda, Bara Erhayiem, Rachel Kan, Adam K. McDiarmid, Pankaj Garg, Tarique A. Musa, Laura E. Dobson, Klaus K. Witte, Mark T. Kearney, Julian H. Barth, Ramzi Ajjan, John P. Greenwood and Sven Plein Tags: Original investigation Source Type: research

MicroRNA-19a contributes to the epigenetic regulation of tissue factor in diabetes
Diabetes mellitus is characterized by chronic vascular disorder and presents a main risk factor for cardiovascular mortality. In particular, hyperglycaemia and inflammatory cytokines induce vascular circulatin... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 24, 2018 Category: Cardiology Authors: Marco Witkowski, Termeh Tabaraie, Daniel Steffens, Julian Friebel, Andrea D örner, Carsten Skurk, Mario Witkowski, Bernd Stratmann, Diethelm Tschoepe, Ulf Landmesser and Ursula Rauch Tags: Original investigation Source Type: research

Long-term visit-to-visit glycemic variability as predictor of micro- and macrovascular complications in patients with type 2 diabetes: The Rio de Janeiro Type 2 Diabetes Cohort Study
Long-term visit-to-visit glycemic variability is an additional measure of glycemic control. We aimed to evaluate the prognostic value of several measures of glycemic variability for the occurrence of micro- an... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 24, 2018 Category: Cardiology Authors: C. R. L. Cardoso, N. C. Leite, C. B. M. Moram and G. F. Salles Tags: Original investigation Source Type: research

The high need for trials assessing functional outcome after stroke rather than stroke prevention with GLP-1 agonists and DPP-4 inhibitors
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 21, 2018 Category: Cardiology Authors: Vladimer Darsalia, Martin Larsson, Thomas Klein and Cesare Patrone Tags: Commentary Source Type: research

Potential role of insulin receptor isoforms and IGF receptors in plaque instability of human and experimental atherosclerosis
Clinical complications associated with atherosclerotic plaques arise from luminal obstruction due to plaque growth or destabilization leading to rupture. We previously demonstrated that overexpression of insul... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 20, 2018 Category: Cardiology Authors: Nuria Beneit, Jos é Luis Martín-Ventura, Carlota Rubio-Longás, Óscar Escribano, Gema García-Gómez, Silvia Fernández, Giorgio Sesti, Marta Letizia Hribal, Jesús Egido, Almudena Gómez-Hernández and Manuel Benito Tags: Original investigation Source Type: research

Report from the 3rd Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes & Cardiovascular Disease (D & CVD) EASD Study Group
The 3rd Cardiovascular Outcome Trial Summit of the Diabetes& Cardiovascular Disease EASD Study Group was held on the 26 –27 October 2017 in Munich. As in 2015 and 2016, this summit was organised in light of re... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 19, 2018 Category: Cardiology Authors: Oliver Schnell, Eberhard Standl, Doina Catrinoiu, Stefano Genovese, Nebojsa Lalic, Katarina Lalic, Jan Skrha, Paul Valensi and Antonio Ceriello Tags: Commentary Source Type: research

Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): a case control study
No study evaluated vascular health markers in subjects with non-alcoholic fatty liver disease (NAFLD) through a combined analysis of reactive hyperemia peripheral arterial tonometry (RH-PAT) and arterial stiff... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 16, 2018 Category: Cardiology Authors: Antonino Tuttolomondo, Salvatore Petta, Alessandra Casuccio, Carlo Maida, Vittoriano Della Corte, Mario Daidone, Domenico Di Raimondo, Rosaria Pecoraro, Roberto Fonte, Anna Cirrincione, Rita Zafonte, Daniela Cabibi, Calogero Camm à, Vito Di Marco, Anna L Tags: Original investigation Source Type: research

Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease
There are inconsistent data about the role of serum phospholipid fatty acid composition in patients with type 2 diabetes (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The aim of the study was to i... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 16, 2018 Category: Cardiology Authors: Malgorzata Poreba, Pawel Rostoff, Aleksander Siniarski, Magdalena Mostowik, Renata Golebiowska-Wiatrak, Jadwiga Nessler, Anetta Undas and Grzegorz Gajos Tags: Original investigation Source Type: research

Control of glycemia and blood pressure in British adults with diabetes mellitus and subsequent therapy choices: a comparison across health states
To examine the intensity of glycemic and blood pressure control in British adults with diabetes mellitus and whether control levels or treatment deintensification rates differ across health states. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 12, 2018 Category: Cardiology Authors: Finlay A. McAlister, Brendan Cord Lethebe, Caitlin Lambe, Tyler Williamson and Mark Lowerison Tags: Original investigation Source Type: research

Reduced coronary collateralization in type 2 diabetic patients with chronic total occlusion
The extent of coronary collateral formation is a primary determinant of the severity of myocardial damage and mortality after coronary artery occlusion. Type 2 diabetes mellitus (T2DM) represents an important ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 8, 2018 Category: Cardiology Authors: Ying Shen, Feng Hua Ding, Yang Dai, Xiao Qun Wang, Rui Yan Zhang, Lin Lu and Wei Feng Shen Tags: Review Source Type: research

Impact of diabetes and early revascularization on the need for late and repeat procedures
Coronary artery disease often progresses more rapidly in diabetics, but the integrated impact of diabetes and early revascularization status on late or repeat revascularization in the contemporary era is less ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 5, 2018 Category: Cardiology Authors: Ady Orbach, David A. Halon, Ronen Jaffe, Ronen Rubinshtein, Basheer Karkabi, Moshe Y. Flugelman and Barak Zafrir Tags: Original investigation Source Type: research

Increase in relative skeletal muscle mass over time and its inverse association with metabolic syndrome development: a 7-year retrospective cohort study
Skeletal muscle mass was negatively associated with metabolic syndrome prevalence in previous cross-sectional studies. The aim of this study was to investigate the impact of baseline skeletal muscle mass and c... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 5, 2018 Category: Cardiology Authors: Gyuri Kim, Seung-Eun Lee, Ji Eun Jun, You-Bin Lee, Jiyeon Ahn, Ji Cheol Bae, Sang-Man Jin, Kyu Yeon Hur, Jae Hwan Jee, Moon-Kyu Lee and Jae Hyeon Kim Tags: Original investigation Source Type: research

Effect of sitagliptin on tissue characteristics of the carotid wall in patients with type 2 diabetes: a post hoc sub-analysis of the sitagliptin preventive study of intima-media thickness evaluation (SPIKE)
This study aimed to evaluate the effect of sitagliptin, a dipeptidyl p... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 5, 2018 Category: Cardiology Authors: Naoto Katakami, Tomoya Mita, Yoko Irie, Mitsuyoshi Takahara, Taka-aki Matsuoka, Masahiko Gosho, Hirotaka Watada and Iichiro Shimomura Tags: Original investigation Source Type: research

How to interpret the role of SDF-1 α on diabetic complications during therapy with DPP-4 inhibitors
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 2, 2018 Category: Cardiology Authors: Gian Paolo Fadini and Angelo Avogaro Tags: Commentary Source Type: research

Glitazones and alpha-glucosidase inhibitors as the second-line oral anti-diabetic agents added to metformin reduce cardiovascular risk in Type 2 diabetes patients: a nationwide cohort observational study
Metformin is the standard first-line drug for patients with Type 2 diabetes (T2DM). However, the optimal second-line oral anti-diabetic agent (ADA) remains unclear. We investigated the cardiovascular risk of v... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 24, 2018 Category: Cardiology Authors: Cheng-Wei Chan, Chu-Leng Yu, Jiunn-Cherng Lin, Yu-Cheng Hsieh, Che-Chen Lin, Chen-Ying Hung, Cheng-Hung Li, Ying-Chieh Liao, Chu-Pin Lo, Jin-Long Huang, Ching-Heng Lin and Tsu-Juey Wu Tags: Original investigation Source Type: research

Association of depression with evolution of heart failure in patients with type 2 diabetes mellitus
Depression is a prevalent, independent predictor of mortality in patients with heart failure (HF). Depression is also common in type 2 diabetes mellitus (T2DM), which is itself an important risk factor for HF.... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 24, 2018 Category: Cardiology Authors: Ying Wang, Hong Yang, Mark Nolan, John Burgess, Kazuaki Negishi and Thomas H. Marwick Tags: Original investigation Source Type: research

Undetected dysglycaemia common in primary care patients treated for hypertension and/or dyslipidaemia: on the need for a screening strategy in clinical practice. A report from EUROASPIRE IV a registry from the EuroObservational Research Programme of the European Society of Cardiology
Dysglycaemia defined as type 2 diabetes (T2DM) and impaired glucose tolerance (IGT), increases the risk of cardiovascular disease (CVD). The negative impact is more apparent in the presence of hypertension and... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 24, 2018 Category: Cardiology Authors: Bahira Shahim, Viveca Gyberg, Dirk De Bacquer, Kornelia Kotseva, Guy De Backer, Oliver Schnell, Jaakko Tuomilehto, David Wood and Lars Ryd én Tags: Original investigation Source Type: research

Individualised treatment targets in patients with type-2 diabetes and hypertension
Patients with type-2 diabetes mellitus (T2DM) are at high risk of cardiovascular events, accentuated in the presence of hypertension. At present, it is unclear to what extent the guidelines for the management ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 22, 2018 Category: Cardiology Authors: Roland E. Schmieder, Diethelm Tsch öpe, Cornelia Koch, Taoufik Ouarrak and Anselm K. Gitt Tags: Original investigation Source Type: research

Metabolic syndrome severity is significantly associated with future coronary heart disease in Type 2 diabetes
The severity of the metabolic syndrome (MetS) is significantly associated with future coronary heart disease (CHD) among individuals without baseline Type 2 diabetes. However, the validity of assessing MetS se... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 19, 2018 Category: Cardiology Authors: Matthew J. Gurka, Yi Guo, Stephanie L. Filipp and Mark D. DeBoer Tags: Original investigation Source Type: research

Influence of apocynin on cardiac remodeling in rats with streptozotocin-induced diabetes mellitus
Increased reactive oxygen species (ROS) generation in diabetes mellitus (DM) is an important mechanism leading to diabetic cardiomyopathy. Apocynin, a drug isolated from the herb Picrorhiza kurroa, is considered ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 17, 2018 Category: Cardiology Authors: R. Gimenes, C. Gimenes, C. M. Rosa, N. P. Xavier, D. H. S. Campos, A. A. H. Fernandes, M. D. M. Cezar, G. N. Guirado, L. U. Pagan, I. D. Chaer, D. C. Fernandes, F. R. Laurindo, A. C. Cicogna, M. P. Okoshi and K. Okoshi Tags: Original investigation Source Type: research

p66Shc gene expression in peripheral blood mononuclear cells and progression of diabetic complications
The risk of diabetic complications is modified by genetic and epigenetic factors. p66Shc drives the hyperglycaemic cell damage and its deletion prevents experimental diabetic complications. We herein tested wheth... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 17, 2018 Category: Cardiology Authors: Gian Paolo Fadini, Mattia Albiero, Benedetta Maria Bonora, Nicol Poncina, Saula Vigili de Kreutzenberg and Angelo Avogaro Tags: Original investigation Source Type: research

Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients
Haptoglobin (Hp) functions as an antioxidant by binding with haemoglobin. We investigated whether serum Hp has a causal effect on macroangiopathy via Mendelian randomization (MR) analysis with common variants ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 16, 2018 Category: Cardiology Authors: Shiyun Wang, Jie Wang, Rong Zhang, Tao Wang, Dandan Yan, Zhen He, Feng Jiang, Cheng Hu and Weiping Jia Tags: Original investigation Source Type: research

Comparison of speckle-tracking echocardiography with invasive hemodynamics for the detection of characteristic cardiac dysfunction in type-1 and type-2 diabetic rat models
Measurement of systolic and diastolic function in animal models is challenging by conventional non-invasive methods. Therefore, we aimed at comparing speckle-tracking echocardiography (STE)-derived parameters ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 16, 2018 Category: Cardiology Authors: Csaba M átyás, Attila Kovács, Balázs Tamás Németh, Attila Oláh, Szilveszter Braun, Márton Tokodi, Bálint András Barta, Kálmán Benke, Mihály Ruppert, Bálint Károly Lakatos, Béla Merkely and Tamás Radovits Tags: Original investigation Source Type: research

Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: role of GLP-1 isoforms in Glut4 receptor trafficking
The distribution of glucose and fatty-acid transporters in the heart is crucial for energy consecution and myocardial function. In this sense, the glucagon-like peptide-1 (GLP-1) enhancer, sitagliptin, improve... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 11, 2018 Category: Cardiology Authors: E. Ram írez, B. Picatoste, A. González-Bris, M. Oteo, F. Cruz, A. Caro-Vadillo, J. Egido, J. Tuñón, M. A. Morcillo and Ó. Lorenzo Tags: Original investigation Source Type: research

Increased epicardial adipose tissue thickness is a predictor of new-onset diabetes mellitus in patients with coronary artery disease treated with high-intensity statins
Statins are widely used for lipid lowering in patients with coronary artery disease (CAD), but increasing evidence indicates an association between statin use and new-onset of diabetes mellitus (NODM). Epicard... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 11, 2018 Category: Cardiology Authors: Jeehoon Kang, Young-Chan Kim, Jin Joo Park, Sehun Kim, Si-Hyuck Kang, Young Jin Cho, Yeonyee E. Yoon, Il-Young Oh, Chang-Hwan Yoon, Jung-Won Suh, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae and Dong-Ju Choi Tags: Original investigation Source Type: research

Relationship between cardiac microvascular dysfunction measured with 82Rubidium-PET and albuminuria in patients with diabetes mellitus
Albuminuria is of one the strongest predictors of cardiovascular disease (CVD) in diabetes. Diabetes is associated with cardiac microvascular dysfunction (CMD), a powerful, independent prognostic factor for ca... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 11, 2018 Category: Cardiology Authors: Louis Potier, Renata Chequer, Ronan Roussel, Kamel Mohammedi, Souad Sismail, Agn ès Hartemann, Chloé Amouyal, Michel Marre, Dominique Le Guludec and Fabien Hyafil Tags: Original investigation Source Type: research