Aggravation of functional mitral regurgitation on left ventricle stiffness in type 2 diabetes mellitus patients evaluated by CMR tissue tracking
This study aimed to investiga... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 31, 2021 Category: Cardiology Authors: Yi Zhang, Wei-feng Yan, Li Jiang, Meng-ting Shen, Yuan Li, Shan Huang, Ke shi and Zhi-gang Yang Tags: Original investigation Source Type: research

Cardiovascular outcomes with sodium –glucose cotransporter-2 inhibitors vs other glucose-lowering drugs in 13 countries across three continents: analysis of CVD-REAL data
Randomized, controlled cardiovascular outcome trials may not be fully representative of the management of patients with type 2 diabetes across different geographic regions. We conducted analyses of data from t... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 31, 2021 Category: Cardiology Authors: Kamlesh Khunti, Mikhail Kosiborod, Dae Jung Kim, Shun Kohsaka, Carolyn S. P. Lam, Su-Yen Goh, Chern-En Chiang, Jonathan E. Shaw, Matthew A. Cavender, Navdeep Tangri, Josep Franch-Nadal, Reinhard W. Holl, Marit E. J ørgensen, Anna Norhammar, Johan G. Erik Tags: Original investigation Source Type: research

Comparison of the clinical effect of empagliflozin on glycemic and non-glycemic parameters in Japanese patients with type 2 diabetes and cardiovascular disease treated with or without baseline metformin
The most recent treatment guidelines for type 2 diabetes (T2D) recommend sodium-glucose cotransporter 2 (SGLT2) inhibitors should be considered preferentially in patients with T2D with either a high cardiovasc... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 31, 2021 Category: Cardiology Authors: Atsushi Tanaka, Michio Shimabukuro, Hiroki Teragawa, Yosuke Okada, Toshinari Takamura, Isao Taguchi, Shigeru Toyoda, Hirofumi Tomiyama, Shinichiro Ueda, Yukihito Higashi and Koichi Node Tags: Original investigation Source Type: research

A molecular signature for the metabolic syndrome by urine metabolomics
Metabolic syndrome (MetS) is a multimorbid long-term condition without consensual medical definition and a diagnostic based on compatible symptomatology. Here we have investigated the molecular signature of Me... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 28, 2021 Category: Cardiology Authors: Chiara Bruzzone, Rub én Gil-Redondo, Marisa Seco, Rocío Barragán, Laura de la Cruz, Claire Cannet, Hartmut Schäfer, Fang Fang, Tammo Diercks, Maider Bizkarguenaga, Beatriz González-Valle, Ana Laín, Arantza Sanz-Parra, Oscar Coltell, Ander López de Tags: Original investigation Source Type: research

Triglyceride-rich lipoprotein and LDL particle subfractions and their association with incident type 2 diabetes: the PREVEND study
Triglyceride-rich lipoproteins particles (TRLP) and low density lipoprotein particles (LDLP) vary in size. Their association with β-cell function is not well described. We determined associations of TRLP and L... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 28, 2021 Category: Cardiology Authors: Sara Sokooti, Jose L. Flores-Guerrero, Hiddo J. L. Heerspink, Margery A. Connelly, Stephan J. L. Bakker and Robin P. F. Dullaart Tags: Original investigation Source Type: research

FGF21/adiponectin ratio predicts deterioration in glycemia: a 4.6-year prospective study in China
The fibroblast growth factor (FGF) 21-adiponectin pathway is involved in the regulation of insulin resistance. However, the relationship between the FGF21-adiponectin pathway and type 2 diabetes in humans is u... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 28, 2021 Category: Cardiology Authors: Dan Liu, Liang Wu, Qiongmei Gao, Xiaoxue Long, Xuhong Hou, Lingling Qian, Jiacheng Ni, Qichen Fang, Huating Li and Weiping Jia Tags: Original investigation Source Type: research

Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults
Succinate is produced by both host and microbiota, with a key role in the interplay of immunity and metabolism and an emerging role as a biomarker for inflammatory and metabolic disorders in middle-aged adults... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 27, 2021 Category: Cardiology Authors: Francisco J. Osuna-Prieto, Borja Martinez-Tellez, Lourdes Ortiz-Alvarez, Xinyu Di, Lucas Jurado-Fasoli, Huiwen Xu, Victoria Ceperuelo-Mallafr é, Catalina Núñez-Roa, Isabelle Kohler, Antonio Segura-Carretero, José V. García-Lario, Angel Gil, Concepci Tags: Original investigation Source Type: research

Pioglitazone use associated with reduced risk of the first attack of ischemic stroke in patients with newly onset type 2 diabetes: a nationwide nested case –control study
Pioglitazone use is known to be associated with a reduced risk of recurrent stroke in patients with diabetes mellitus (DM) who have a history of stroke. However, it is unclear whether this benefit extends to p... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 27, 2021 Category: Cardiology Authors: Junghee Ha, Dong-Woo Choi, Keun You Kim, Chung Mo Nam and Eosu Kim Tags: Original investigation Source Type: research

The impact of central obesity on the risk of hospitalization or death due to heart failure in type 1 diabetes: a 16-year cohort study
Obesity and type 2 diabetes are well-known risk factors for heart failure (HF). Although obesity has increased in type 1 diabetes, studies regarding HF in this population are scarce. Therefore, we investigated... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 27, 2021 Category: Cardiology Authors: Erika B. Parente, Valma Harjutsalo, Carol Forsblom and Per-Henrik Groop Tags: Original investigation Source Type: research

CAPTURE: a multinational, cross-sectional study of cardiovascular disease prevalence in adults with type 2 diabetes across 13 countries
There is a paucity of global data on cardiovascular disease (CVD) prevalence in people with type 2 diabetes (T2D). The primary objective of the CAPTURE study was to estimate the prevalence of established CVD a... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 27, 2021 Category: Cardiology Authors: Ofri Mosenzon, Abdullah Alguwaihes, Jose Luis Arenas Leon, Fahri Bayram, Patrice Darmon, Timothy M. E. Davis, Guillermo Dieuzeide, Kirsten T. Eriksen, Tianpei Hong, Margit S. Kaltoft, Csaba Lengyel, Nicolai A. Rhee, Giuseppina T. Russo, Shinichiro Shirabe Tags: Original investigation Source Type: research

Higher long-term visit-to-visit glycemic variability predicts new-onset atrial fibrillation in patients with diabetes mellitus
Atrial fibrillation (AF) is prevalent in patients with type 2 diabetes mellitus (T2DM). Glycemic variability (GV) is associated with risk of micro- and macrovascular diseases. However, whether the GV can incre... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 23, 2021 Category: Cardiology Authors: Jung-Chi Hsu, Yen-Yun Yang, Shu-Lin Chuang, Chih-Chieh Yu and Lian-Yu Lin Tags: Original investigation Source Type: research

Diabetes induces remodeling of the left atrial appendage independently of atrial fibrillation in a rodent model of type-2 diabetes
Diabetic patients have an increased predisposition to thromboembolic events, in most cases originating from thrombi in the left atrial appendage (LAA). Remodeling of the LAA, which predisposes to thrombi forma... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 23, 2021 Category: Cardiology Authors: Or Yosefy, Barucha Sharon, Chana Yagil, Mark Shlapoberski, Alejandro Livoff, Ilana Novitski, Ronen Beeri, Yoram Yagil and Chaim Yosefy Tags: Original investigation Source Type: research

The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin
Empagliflozin (EMPA), a selective inhibitor of the sodium glucose co-transporter 2, reduced the risk of hospitalization for heart failure and cardiovascular death in type 2 diabetic patients in the EMPA ‐REG OU... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 23, 2021 Category: Cardiology Authors: Vincenzo Quagliariello, Michelino De Laurentiis, Domenica Rea, Antonio Barbieri, Maria Gaia Monti, Andreina Carbone, Andrea Paccone, Lucia Altucci, Mariarosaria Conte, Maria Laura Canale, Gerardo Botti and Nicola Maurea Tags: Original investigation Source Type: research

Epicardial adipose tissue and severe Coronavirus Disease 19
Both visceral adipose tissue and epicardial adipose tissue (EAT) have pro-inflammatory properties. The former is associated with Coronavirus Disease 19 (COVID-19) severity. We aimed to investigate whether an a... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 20, 2021 Category: Cardiology Authors: H élène Bihan, Richard Heidar, Aude Beloeuvre, Lucie Allard, Elise Ouedraogo, Sopio Tatulashvili, Yacine Tandjaoui, Stephane Gaudry, Pierre-Yves Brillet and Emmanuel Cosson Tags: Original investigation Source Type: research

Improving statin treatment strategies to reduce LDL-cholesterol: factors associated with targets ’ attainment in subjects with and without type 2 diabetes
This cross-sectional study aimed to identify actionable factors to improve LDL-cholesterol target achievement and overcome underuse of lipid-lowering treatments in high- or very-high-cardiovascular risk patients. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 16, 2021 Category: Cardiology Authors: Mario Luca Morieri, Valentina Perrone, Chiara Veronesi, Luca Degli Esposti, Margherita Andretta, Mario Plebani, Gian Paolo Fadini, Saula Vigili de Kreutzenberg and Angelo Avogaro Tags: Original investigation Source Type: research

Efficacy and durability of multifactorial intervention on mortality and MACEs: a randomized clinical trial in type-2 diabetic kidney disease
Multiple modifiable risk factors for late complications in patients with diabetic kidney disease (DKD), including hyperglycemia, hypertension and dyslipidemia, increase the risk of a poor outcome. DKD is assoc... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 16, 2021 Category: Cardiology Authors: Ferdinando Carlo Sasso, Pia Clara Pafundi, Vittorio Simeon, Luca De Nicola, Paolo Chiodini, Raffaele Galiero, Luca Rinaldi, Riccardo Nevola, Teresa Salvatore, Celestino Sardu, Raffaele Marfella, Luigi Elio Adinolfi and Roberto Minutolo Tags: Original investigation Source Type: research

Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study
Triglyceride –glucose (TyG) index, a simple surrogate marker of insulin resistance, has been reported to be associated with arterial stiffness. However, previous studies were limited by the cross-sectional desi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 16, 2021 Category: Cardiology Authors: Shouling Wu, Luli Xu, Mingyang Wu, Shuohua Chen, Youjie Wang and Yaohua Tian Tags: Original investigation Source Type: research

Prognostic value of fibrinogen in patients with coronary artery disease and prediabetes or diabetes following percutaneous coronary intervention: 5-year findings from a large cohort study
Fibrinogen (FIB) is an independent risk factor for mortality and cardiovascular events in the general population. However, the relationship between FIB and long-term mortality among CAD patients undergoing PCI... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 16, 2021 Category: Cardiology Authors: Deshan Yuan, Ping Jiang, Pei Zhu, Sida Jia, Ce Zhang, Yue Liu, Ru Liu, Jingjing Xu, Xiaofang Tang, Xueyan Zhao, Runlin Gao, Yuejin Yang, Bo Xu, Zhan Gao and Jinqing Yuan Tags: Original investigation Source Type: research

Assessment of heart rate variability (HRV) in subjects with type 2 diabetes mellitus with and without diabetic foot: correlations with endothelial dysfunction indices and markers of adipo-inflammatory dysfunction
Some studies have suggested that patients with diabetes and foot complications have worse cardiovascular and cerebrovascular risk profiles, higher degrees of endothelial dysfunction and arterial stiffness and ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 14, 2021 Category: Cardiology Authors: Antonino Tuttolomondo, Alessandro Del Cuore, Alessandro La Malfa, Alessandra Casuccio, Mario Daidone, Carlo Domenico Maida, Domenico Di Raimondo, Tiziana Di Chiara, Maria Grazia Puleo, Rosario Norrito, Giovanni Guercio and Antonio Pinto Tags: Original investigation Source Type: research

Weight change and risk of cardiovascular disease among adults with type 2 diabetes: more than 14 years of follow-up in the Tehran Lipid and Glucose Study
To examine the impact of weight change on incident cardiovascular disease and coronary heart disease (CVD/CHD) among an Iranian population with type 2 diabetes mellitus (T2DM). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 12, 2021 Category: Cardiology Authors: Seyyed Saeed Moazzeni, Reyhane Hizomi Arani, Niloofar Deravi, Mitra Hasheminia, Davood Khalili, Fereidoun Azizi and Farzad Hadaegh Tags: Original investigation Source Type: research

Statins and clinical outcomes in hospitalized COVID-19 patients with and without Diabetes Mellitus: a retrospective cohort study with propensity score matching
This study aims to determine the association between inpatient statin use and severe disease outcomes among hospitalized COVID-19... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 10, 2021 Category: Cardiology Authors: Prateek Lohia, Shweta Kapur, Sindhuri Benjaram, Zachary Cantor, Navid Mahabadi, Tanveer Mir and M. Safwan Badr Tags: Original investigation Source Type: research

Sex-related disparities in the incidence and outcomes of hemorrhagic stroke among type 2 diabetes patients: a propensity score matching analysis using the Spanish National Hospital Discharge Database for the period 2016 –18
To analyze incidence, use of therapeutic procedures, use of oral anticoagulants (OACs) and antiplatelet agents prior to hospitalization, and in-hospital outcomes among patients who were hospitalized with hemor... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 9, 2021 Category: Cardiology Authors: Ana Lopez-de-Andres, Rodrigo Jimenez-Garcia, Valent ín Hernández-Barrera, Isabel Jiménez-Trujillo, José M. de Miguel-Yanes, David Carabantes-Alarcon, Javier de Miguel-Diez and Marta Lopez-Herranz Tags: Original investigation Source Type: research

Cardiovascular and mortality benefits of sodium –glucose co-transporter-2 inhibitors in patients with type 2 diabetes mellitus: CVD-Real Catalonia
Evidence from prospective cardiovascular (CV) outcome trials in type 2 diabetes (T2DM) patients supports the use of sodium –glucose co-transporter-2 inhibitors (SGLT2i) to reduce the risk of CV events. In this ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 9, 2021 Category: Cardiology Authors: Jordi Real, Bogdan Vlacho, Emilio Ortega, Joan Antoni Vall és, Manel Mata-Cases, Esmeralda Castelblanco, Eric T. Wittbrodt, Peter Fenici, Mikhail Kosiborod, Dídac Mauricio and Josep Franch-Nadal Tags: Original investigation Source Type: research

Triglyceride-glucose index is associated with in-stent restenosis in patients with acute coronary syndrome after percutaneous coronary intervention with drug-eluting stents
The triglyceride-glucose (TyG) index is an alternative marker of insulin resistance (IR) and is closely associated with the prevalence and prognosis of atherosclerotic cardiovascular disease (ASCVD). However, ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 8, 2021 Category: Cardiology Authors: Yong Zhu, Kesen Liu, Maolin Chen, Yan Liu, Ang Gao, Chengping Hu, Hong Li, Huagang Zhu, Hongya Han, Jianwei Zhang and Yingxin Zhao Tags: Original investigation Source Type: research

A cross sectional study to compare cardiac structure and diastolic function in adolescents and young adults with youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study
To compare left ventricular structure (LV) and diastolic function in young adults with youth- onset diabetes by type, determine the prevalence of abnormal diastolic function by diabetes type using published va... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 7, 2021 Category: Cardiology Authors: Amy S. Shah, Scott Isom, Dana Dabelea, Ralph D ’Agostino Jr., Lawrence M. Dolan, Lynne Wagenknecht, Giuseppina Imperatore, Sharon Saydah, Angela D. Liese, Jean M. Lawrence, Cate Pihoker and Elaine M. Urbina Tags: Original investigation Source Type: research

Up and down waves of glycemic control and lower-extremity amputation in diabetes
Lower extremity amputations (LEA) are associated with a high mortality and medical expenditure. Diabetes accounts for 45% to 70% of LEA and is one of the most potent risk factors for peripheral artery diseases... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 6, 2021 Category: Cardiology Authors: Paola Caruso, Lorenzo Scappaticcio, Maria Ida Maiorino, Katherine Esposito and Dario Giugliano Tags: Commentary Source Type: research

Importance of hematological parameters for micro- and macrovascular outcomes in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study
The prognostic importance of several hematological parameters has been scarcely investigated in type 2 diabetes. So, we aimed to evaluate their prognostic importance for development of complications in a cohor... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 6, 2021 Category: Cardiology Authors: Claudia R. L. Cardoso, Nathalie C. Leite and Gil F. Salles Tags: Original investigation Source Type: research

Association of TyG index and TG/HDL-C ratio with arterial stiffness progression in a non-normotensive population
This study aim... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 6, 2021 Category: Cardiology Authors: Zhiyuan Wu, Di Zhou, Yue Liu, Zhiwei Li, Jinqi Wang, Ze Han, Xinlei Miao, Xiangtong Liu, Xia Li, Wei Wang, Xiuhua Guo and Lixin Tao Tags: Original investigation Source Type: research

The impact of empagliflozin on cardiac physiology and fibrosis early after myocardial infarction in non-diabetic rats
Myocardial fibrosis is a multistep process, which results in collagen deposition in the injured muscle. Empagliflozin, a sodium-glucose cotransporter 2 inhibitor (SGLT2i), decreases cardiovascular events risk.... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 2, 2021 Category: Cardiology Authors: Elias Daud, Offir Ertracht, Nadav Bandel, Gassan Moady, Monah Shehadeh, Tali Reuveni and Shaul Atar Tags: Original investigation Source Type: research

Triglyceride glucose index combined with plaque characteristics as a novel biomarker for cardiovascular outcomes after percutaneous coronary intervention in ST-elevated myocardial infarction patients: an intravascular optical coherence tomography study
This prospective study explored plaque morphology according to the underlying culprit lesion pathology (rupture versus erosion) in relation to the triglyceride glucose (TyG) index in patients with acute ST-ele... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 28, 2021 Category: Cardiology Authors: Xiaoxiao Zhao, Ying Wang, Runzhen Chen, Jiannan Li, Jinying Zhou, Chen Liu, Peng Zhou, Zhaoxue Sheng, Yi Chen, Li Song, Hanjun Zhao and Hongbing Yan Tags: Original investigation Source Type: research

Reduction of estimated fluid volumes following initiation of empagliflozin in patients with type 2 diabetes and cardiovascular disease: a secondary analysis of the placebo-controlled, randomized EMBLEM trial
Sodium glucose co-transporter 2 inhibitors promote osmotic/natriuretic diuresis and reduce excess fluid volume, and this improves cardiovascular outcomes, including hospitalization for heart failure. We sought... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 28, 2021 Category: Cardiology Authors: Atsushi Tanaka, Michio Shimabukuro, Hiroki Teragawa, Yosuke Okada, Toshinari Takamura, Isao Taguchi, Shigeru Toyoda, Hirofumi Tomiyama, Shinichiro Ueda, Yukihito Higashi and Koichi Node Tags: Original investigation Source Type: research

Prescribing sodium-glucose co-transporter-2 inhibitors for type 2 diabetes in primary care: influence of renal function and heart failure diagnosis
Sodium-glucose co-transporter-2 inhibitors (SGLT-2is) are licenced for initiation for glucose lowering in people with type 2 diabetes (T2DM) with an estimated glomerular filtration rate (eGFR)  ≥ 60 mL/min/1.73m2)... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 28, 2021 Category: Cardiology Authors: William Hinton, Michael D. Feher, Neil Munro, Mark Joy and Simon de Lusignan Tags: Original investigation Source Type: research

Advanced glycation end-products, measured as skin autofluorescence, associate with vascular stiffness in diabetic, pre-diabetic and normoglycemic individuals: a cross-sectional study
Advanced glycation end-products are proteins that become glycated after contact with sugars and are implicated in endothelial dysfunction and arterial stiffening. We aimed to investigate the relationships betw... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 27, 2021 Category: Cardiology Authors: Anna Birukov, Rafael Cuadrat, Elli Polemiti, Fabian Eichelmann and Matthias B. Schulze Tags: Original investigation Source Type: research

Mortality rates and cardiovascular disease burden in type 2 diabetes by occupation, results from all Swedish employees in 2002 –2015
This study can contribute in the creation ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 26, 2021 Category: Cardiology Authors: Sofia Carlsson, Tomas Andersson, Mats Talb äck and Maria Feychting Tags: Original investigation Source Type: research

Triglyceride-glucose index in the development of peripheral artery disease: findings from the Atherosclerosis Risk in Communities (ARIC) Study
It remains unclear whether triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, is prospectively associated with incident peripheral arterial disease (PAD). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 24, 2021 Category: Cardiology Authors: Jing-Wei Gao, Qing-Yun Hao, Ming Gao, Kun Zhang, Xiong-Zhi Li, Jing-Feng Wang, Dominique A. Vuitton, Shao-Ling Zhang and Pin-Ming Liu Tags: Original investigation Source Type: research

Circulating ANGPTL8 levels and risk of kidney function decline: Results from the 4C Study
This study aimed to investigate circulating levels of ANGPTL8 and its ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 24, 2021 Category: Cardiology Authors: Huajie Zou, Yongping Xu, Xiaoyu Meng, Danpei Li, Xi Chen, Tingting Du, Yan Yang, Yong Chen, Shiying Shao, Gang Yuan, Xinrong Zhou, Shuhong Hu, Wentao He, Delin Ma, Junhui Xie, Benping Zhang & hellip; Tags: Original investigation Source Type: research

Relationship between diabetes mellitus and atrial fibrillation prevalence in the Polish population: a report from the Non-invasive Monitoring for Early Detection of Atrial Fibrillation (NOMED-AF) prospective cross-sectional observational study
The global burden of atrial fibrillation (AF) and diabetes mellitus (DM) is constantly rising, leading to an increasing healthcare burden of stroke. AF often remains undiagnosed due to the occurrence in an asy... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 24, 2021 Category: Cardiology Authors: Jakub Gumprecht, Gregory Y. H. Lip, Adam Sokal, Beata Średniawa, Katarzyna Mitręga, Jakub Stokwiszewski, Łukasz Wierucki, Aleksandra Rajca, Marcin Rutkowski, Tomasz Zdrojewski, Tomasz Grodzicki, Jarosław Kaźmierczak, Grzegorz Opolski and Zbigniew Kal Tags: Original investigation Source Type: research

Mechanisms of reduced peak oxygen consumption in subjects with uncomplicated type 2 diabetes
Type 2 diabetes mellitus (T2D) increases the risk of incident heart failure (HF), whose earliest fingerprint is effort intolerance (i.e. impaired peak oxygen consumption, or VO2peak). In the uncomplicated T2D pop... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 22, 2021 Category: Cardiology Authors: Lorenzo Nesti, Nicola Riccardo Pugliese, Paolo Sciuto, Nicol ò De Biase, Matteo Mazzola, Iacopo Fabiani, Domenico Trico, Stefano Masi and Andrea Natali Tags: Original investigation Source Type: research

Relation of insulin treatment for type 2 diabetes to the risk of major adverse cardiovascular events after acute coronary syndrome: an analysis of the BETonMACE randomized clinical trial
In stable patients with type 2 diabetes (T2D), insulin treatment is associated with elevated risk for major adverse cardiovascular events (MACE). Patients with acute coronary syndrome (ACS) and T2D are at part... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 22, 2021 Category: Cardiology Authors: Gregory G. Schwartz, Stephen J. Nicholls, Peter P. Toth, Michael Sweeney, Christopher Halliday, Jan O. Johansson, Norman C. W. Wong, Ewelina Kulikowski, Kamyar Kalantar-Zadeh, Henry N. Ginsberg and Kausik K. Ray Tags: Original investigation Source Type: research

Incidence of atrial fibrillation, ischaemic heart disease and heart failure in patients with diabetes
Diabetes has strongly been linked to atrial fibrillation, ischaemic heart disease and heart failure. The epidemiology of these cardiovascular diseases is changing, however, due to changes in prevalence of obes... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 16, 2021 Category: Cardiology Authors: Amy Groenewegen, Victor W. Zwartkruis, Bet ül Cekic, Rudolf. A. de Boer, Michiel Rienstra, Arno W. Hoes, Frans H. Rutten and Monika Hollander Tags: Original investigation Source Type: research

Long-term prognosis in patients with acute myocardial infarction and newly detected glucose abnormalities: predictive value of oral glucose tolerance test and HbA1c
Disturbances of glucose metabolism can be diagnosed by an oral glucose tolerance test (OGTT) and by glycated haemoglobin (HbA1c). The aim of this study was to investigate the association between newly detected... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 14, 2021 Category: Cardiology Authors: Stelios Karayiannides, Catarina Djupsj ö, Jeanette Kuhl, Claes Hofman-Bang, Anna Norhammar, Martin J. Holzmann and Pia Lundman Tags: Original investigation Source Type: research

Correction to: Diabetes, cardiovascular disease and the microcirculation
An amendment to this paper has been published and can be accessed via the original article. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 11, 2021 Category: Cardiology Authors: W. David Strain and P. M. Pald ánius Tags: Correction Source Type: research

Dapagliflozin: a sodium –glucose cotransporter 2 inhibitor, attenuates angiotensin II-induced cardiac fibrotic remodeling by regulating TGFβ1/Smad signaling
Cardiac remodeling is one of the major risk factors for heart failure. In patients with type 2 diabetes, sodium –glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of the first hospitalization for heart... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 11, 2021 Category: Cardiology Authors: Yuze Zhang, Xiaoyan Lin, Yong Chu, Xiaoming Chen, Heng Du, Hailin Zhang, Changsheng Xu, Hong Xie, Qinyun Ruan, Jinxiu Lin, Jie Liu, Jinzhang Zeng, Ke Ma and Dajun Chai Tags: Original investigation Source Type: research

High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery
Information about the renin –angiotensin–aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in rel... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 9, 2021 Category: Cardiology Authors: Lucia La Sala, Elena Tagliabue, Elaine Vieira, Antonio E Pontiroli and Franco Folli Tags: Original investigation Source Type: research

Correction to: SGLT2 inhibitors and lower limb complications: an updated meta-analysis
An amendment to this paper has been published and can be accessed via the original article. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 9, 2021 Category: Cardiology Authors: Chu Lin, Xingyun Zhu, Xiaoling Cai, Wenjia Yang, Fang Lv, Lin Nie and Linong Ji Tags: Correction Source Type: research

Effect of renal denervation on long-term outcomes in patients with resistant hypertension
Increasing studies strongly prove that renal denervation, a minimally invasive surgery, is a promising new non-drug treatment method that can effectively control blood pressure in patients with resistant hyper... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 5, 2021 Category: Cardiology Authors: Bo Liang, Yi Liang, Rui Li and Ning Gu Tags: Commentary Source Type: research

Diastolic dysfunction in a pre-clinical model of diabetes is associated with changes in the cardiac non-myocyte cellular composition
Diabetes is associated with a significantly elevated risk of cardiovascular disease and its specific pathophysiology remains unclear. Recent studies have changed our understanding of cardiac cellularity, with ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 1, 2021 Category: Cardiology Authors: Charles D. Cohen, Miles J. De Blasio, Man K. S. Lee, Gabriella E. Farrugia, Darnel Prakoso, Crisdion Krstevski, Minh Deo, Daniel G. Donner, Helen Kiriazis, Michelle C. Flynn, Taylah L. Gaynor, Andrew J. Murphy, Grant R. Drummond, Alexander R. Pinto and Re Tags: Original investigation Source Type: research

The TRIB3 R84 variant is associated with increased left ventricular mass in a sample of 2426 White individuals
Prior studies in animal models showed that increased cardiac expression of TRIB3 has a pathogenic role in inducing left ventricular mass (LVM). Whether alterations in TRIB3 expression or function have a pathog... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 29, 2021 Category: Cardiology Authors: Gaia Chiara Mannino, Carolina Averta, Teresa Vanessa Fiorentino, Elena Succurro, Rosangela Spiga, Elettra Mancuso, Sofia Miceli, Maria Perticone, Angela Sciacqua, Francesco Andreozzi and Giorgio Sesti Tags: Original investigation Source Type: research

Association between carotid plaque vulnerability and high mobility group box-1 serum levels in a diabetic population
Carotid atherosclerosis represents one of the complications of diabetes mellitus. In particular, plaque instability contributes to disease progression and stroke incidence. High mobility group box-1 (HMGB1) is... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 27, 2021 Category: Cardiology Authors: Federico Biscetti, Giovanni Tinelli, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Flavia Angelini, Giuseppe Straface, Marco Filipponi, Vincenzo Arena, Dario Pitocco, Antonio Gasbarrini, Massimo Massetti and Andrea Flex Tags: Original investigation Source Type: research

Change in triglyceride-glucose index predicts the risk of cardiovascular disease in the general population: a prospective cohort study
Previous studies has shown a significant relationship between baseline triglyceride-glucose (TyG) index and subsequent cardiovascular disease (CVD). However, the effect of longitudinal changes in TyG index on ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 26, 2021 Category: Cardiology Authors: Anxin Wang, Xue Tian, Yingting Zuo, Shuohua Chen, Xia Meng, Shouling Wu and Yongjun Wang Tags: Original investigation Source Type: research