Meta-analysis of the impact of alpha-glucosidase inhibitors on incident diabetes and cardiovascular outcomes
Alpha-glucosidase inhibitors (AGIs) have been shown to reduce incident type 2 diabetes but their impact on cardiovascular (CV) disease remains controversial. We sought to identify the overall impact of AGIs wi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 17, 2019 Category: Cardiology Authors: Ruth L. Coleman, Charles A. B. Scott, Zhihui Lang, M. Angelyn Bethel, Jaakko Tuomilehto and Rury R. Holman Tags: Original investigation Source Type: research

Impact of free fatty acids on prognosis in coronary artery disease patients under different glucose metabolism status
The aim of the present study is to examine the effects of free fatty acids (FFAs) on major cardiovascular events (MACEs) in patients with stable coronary artery disease (CAD) and different glucose metabolism s... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 14, 2019 Category: Cardiology Authors: Jing-Lu Jin, Ye-Xuan Cao, Hui-Hui Liu, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Rui-Xia Xu, Ying Gao, Jing Sun, Qian Dong and Jian-Jun Li Tags: Original investigation Source Type: research

Hypomagnesemia is associated with new-onset diabetes mellitus following heart transplantation
Diabetes mellitus (DM) is a major cause of morbidity and mortality following heart transplantation (HT), with 21% and 35% of survivors being affected within 1 and 5 years following HT, respectively. Magnesium ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 11, 2019 Category: Cardiology Authors: Yael Peled, Eilon Ram, Jacob Lavee, Alexander Tenenbaum, Enrique Z. Fisman, Dov Freimark, Robert Klempfner, Leonid Sternik and Michael Shechter Tags: Original investigation Source Type: research

Phenotyping diabetic cardiomyopathy in Europeans and South Asians
The pathogenesis and cardiovascular impact of type 2 diabetes (T2D) may be different in South Asians compared with other ethnic groups. The phenotypic characterization of diabetic cardiomyopathy remains debate... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 11, 2019 Category: Cardiology Authors: Elisabeth H. M. Paiman, Huub J. van Eyk, Maurice B. Bizino, Ilona A. Dekkers, Paul de Heer, Johannes W. A. Smit, Ingrid M. Jazet and Hildo J. Lamb Tags: Original investigation Source Type: research

Genetic predisposition to type 2 diabetes is associated with severity of coronary artery disease in patients with acute coronary syndromes
Accumulating evidence has shown that type 2 diabetes (T2D) and coronary artery disease (CAD) may stem from a ‘common soil’. The aim of our study was to examine the association between genetic predisposition to... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 8, 2019 Category: Cardiology Authors: Qiwen Zheng, Jie Jiang, Yong Huo and Dafang Chen Tags: Original investigation Source Type: research

Greater glucagon-like peptide-1 responses to oral glucose are associated with lower central and peripheral blood pressures
Cardiovascular diseases (CVDs) are globally the leading cause of death and hypertension is a significant risk factor. Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists has been associated with d... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 5, 2019 Category: Cardiology Authors: Julie R. Lundgren, Kristine F ærch, Daniel R. Witte, Anna E. Jonsson, Oluf Pedersen, Torben Hansen, Torsten Lauritzen, Jens J. Holst, Dorte Vistisen, Marit E. Jørgensen, Signe S. Torekov and Nanna B. Johansen Tags: Original investigation Source Type: research

Lessons learned from the DAPA-HF trial concerning the mechanisms of benefit of SGLT2 inhibitors on heart failure events in the context of other large-scale trials nearing completion
Four large-scale trials in type 2 diabetes have shown that sodium-glucose cotransporter 2 (SGLT2) inhibitors prevent the occurrence of serious heart failure events. Additionally, the DAPA-HF trial demonstrated... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 4, 2019 Category: Cardiology Authors: Milton Packer Tags: Commentary Source Type: research

Effects of 1 year of exercise training versus combined exercise training and weight loss on body composition, low-grade inflammation and lipids in overweight patients with coronary artery disease: a randomized trial
Dyslipidaemia and low-grade inflammation are central in atherogenesis and linked to overweight and physical inactivity. Lifestyle changes are important in secondary prevention of coronary artery disease (CAD).... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 1, 2019 Category: Cardiology Authors: Lene R ørholm Pedersen, Rasmus Huan Olsen, Christian Anholm, Arne Astrup, Jesper Eugen-Olsen, Mogens Fenger, Lene Simonsen, Rosemary L. Walzem, Steen Bendix Haugaard and Eva Prescott Tags: Original investigation Source Type: research

The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study
Being obese or underweight, and having diabetes are important risk factors for new-onset atrial fibrillation (AF). However, it is unclear whether there is any interaction between body weight and diabetes in re... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 1, 2019 Category: Cardiology Authors: Yun Gi Kim, Kyung-Do Han, Jong-Il Choi, Ki Yung Boo, Do Young Kim, Suk-Kyu Oh, Kwang-No Lee, Jaemin Shim, Jin Seok Kim and Young-Hoon Kim Tags: Original investigation Source Type: research

Pericoronary fat inflammation and Major Adverse Cardiac Events (MACE) in prediabetic patients with acute myocardial infarction: effects of metformin
Pericoronary adipose tissue inflammation might lead to the development and destabilization of coronary plaques in prediabetic patients. Here, we evaluated inflammation and leptin to adiponectin ratio in perico... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 30, 2019 Category: Cardiology Authors: Celestino Sardu, Nunzia D ’Onofrio, Michele Torella, Michele Portoghese, Francesco Loreni, Simone Mureddu, Giuseppe Signoriello, Lucia Scisciola, Michelangela Barbieri, Maria Rosaria Rizzo, Marilena Galdiero, Marisa De Feo, Maria Luisa Balestrieri, Gius Tags: Original investigation Source Type: research

Atrial fibrillation and its arrhythmogenesis associated with insulin resistance
Insulin resistance (IR) is considered as a risk factor for atrial fibrillation (AF) even before diabetes develops. The pathophysiology and underlying mechanism are largely unclear. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 26, 2019 Category: Cardiology Authors: Yi-Hsin Chan, Gwo-Jyh Chang, Ying-Ju Lai, Wei-Jan Chen, Shang-Hung Chang, Li-Man Hung, Chi-Tai Kuo and Yung-Hsin Yeh Tags: Original investigation Source Type: research

Renal glucosuria is associated with lower body weight and lower rates of elevated systolic blood pressure: results of a nationwide cross-sectional study of 2.5 million adolescents
Gene coding mutations found in sodium glucose co-transporters (SGLTs) are known to cause renal glucosuria. SGLT2 inhibitors have recently been shown to be effective hypoglycemic agents as well as possessing ca... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 25, 2019 Category: Cardiology Authors: Boris Fishman, Gadi Shlomai, Gilad Twig, Estela Derazne, Alexander Tenenbaum, Enrique Z. Fisman, Adi Leiba and Ehud Grossman Tags: Original investigation Source Type: research

Comparative risk evaluation for cardiovascular events associated with dapagliflozin vs. empagliflozin in real-world type 2 diabetes patients: a multi-institutional cohort study
To compare the cardiovascular event risk in type 2 diabetes patients newly receiving dapagliflozin vs. empagliflozin. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 24, 2019 Category: Cardiology Authors: Shih-Chieh Shao, Kai-Cheng Chang, Ming-Jui Hung, Ning-I Yang, Yuk-Ying Chan, Hui-Yu Chen, Yea-Huei Kao Yang and Edward Chia-Cheng Lai Tags: Original investigation Source Type: research

Disease –treatment interactions in the management of patients with obesity and diabetes who have atrial fibrillation: the potential mediating influence of epicardial adipose tissue
Both obesity and type 2 diabetes are important risk factors for atrial fibrillation (AF), possibly because they both cause an expansion of epicardial adipose tissue, which is the source of proinflammatory adip... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 24, 2019 Category: Cardiology Authors: Milton Packer Tags: Hypothesis Source Type: research

Intrinsic calcification angle: a novel feature of the vulnerable coronary plaque in patients with type 2 diabetes: an optical coherence tomography study
Coronary calcification is associated with high risk for cardiovascular events. However, its impact on plaque vulnerability is incompletely understood. In the present study we defined the intrinsic calcificatio... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 24, 2019 Category: Cardiology Authors: Sebastian Reith, Andrea Milzi, Enrico Domenico Lemma, Rosalia Dettori, Kathrin Burgmaier, Nikolaus Marx and Mathias Burgmaier Tags: Original investigation Source Type: research

Serial coronary computed tomography angiography-verified coronary plaque progression: comparison of stented patients with or without diabetes
Patients with Diabetes mellitus (DM) are susceptible to coronary artery disease (CAD). However, the impact of DM on plaque progression in the non-stented segments of stent-implanted patients has been rarely re... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 24, 2019 Category: Cardiology Authors: Rui Shi, Ke Shi, Zhi-gang Yang, Ying-kun Guo, Kai-yue Diao, Yue Gao, Yi Zhang and Shan Huang Tags: Original investigation Source Type: research

Staged complete revascularization or culprit-only percutaneous coronary intervention for multivessel coronary artery disease in patients with ST-segment elevation myocardial infarction and diabetes
Recently, several randomized trials have noted improved outcomes with staged percutaneous coronary intervention (PCI) of nonculprit vessels in patients with ST-segment elevation myocardial infarction (STEMI) a... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 17, 2019 Category: Cardiology Authors: Kongyong Cui, Shuzheng Lyu, Hong Liu, Xiantao Song, Fei Yuan, Feng Xu, Min Zhang, Wei Wang, Mingduo Zhang, Dongfeng Zhang and Jinfan Tian Tags: Original investigation Source Type: research

Improved long-term cardiovascular outcomes after intensive versus standard screening of diabetic complications: an observational study
In this study, we evaluated whether intensive versus standard compl... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 16, 2019 Category: Cardiology Authors: Mario Luca Morieri, Enrico Longato, Marta Mazzucato, Barbara Di Camillo, Arianna Cocchiglia, Lorenzo Gubian, Giovanni Sparacino, Angelo Avogaro, Gian Paolo Fadini and Saula Vigili de Kreutzenberg Tags: Original investigation Source Type: research

Metformin therapy in patients with diabetes mellitus is associated with a reduced risk of vasculopathy and cardiovascular mortality after heart transplantation
Cardiac allograft vasculopathy (CAV) is a major cause of morbidity and mortality following heart transplantation (HT). Reduced cardiovascular mortality and morbidity have been reported in non-HT patients treat... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 16, 2019 Category: Cardiology Authors: Eilon Ram, Jacob Lavee, Alexander Tenenbaum, Robert Klempfner, Enrique Z. Fisman, Elad Maor, Tal Ovdat, Sergei Amunts, Leonid Sternik and Yael Peled Tags: Original investigation Source Type: research

Sitagliptin does not reduce the risk of cardiovascular death or hospitalization for heart failure following myocardial infarction in patients with diabetes: observations from TECOS
To examine the effects of the DPP-4i sitagliptin on CV outcomes during and after incident MI in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 3, 2019 Category: Cardiology Authors: Michael A. Nauck, Darren K. McGuire, Karen S. Pieper, Yuliya Lokhnygina, Timo E. Strandberg, Axel Riefflin, Tuncay Delibasi, Eric D. Peterson, Harvey D. White, Russell Scott and Rury R. Holman Tags: Original investigation Source Type: research

Evidence from routine clinical practice: EMPRISE provides a new perspective on CVOTs
EMPA-REG OUTCOME is recognised by international guidelines as a landmark study that showed a significant cardioprotective benefit with empagliflozin in patients with type 2 diabetes (T2D) and cardiovascular di... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 31, 2019 Category: Cardiology Authors: Guntram Schernthaner, Avraham Karasik, Agn ė Abraitienė, Alexander S. Ametov, Zsolt Gaàl, Janusz Gumprecht, Andrej Janež, Susanne Kaser, Katarina Lalić, Boris N. Mankovsky, Evgeny Moshkovich, Marju Past, Martin Prázný, Gabriela Radulian, Lea Smirč Tags: Commentary Source Type: research

Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review
In the light of growing global epidemic of type 2 diabetes mellitus (T2DM), significant efforts are made to discover next-generation biomarkers for early detection of the disease. Multiple mechanisms including... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 30, 2019 Category: Cardiology Authors: Justyna Pordzik, Daniel Jakubik, Joanna Jarosz-Popek, Zofia Wicik, Ceren Eyileten, Salvatore De Rosa, Ciro Indolfi, Jolanta M. Siller-Matula, Pamela Czajka and Marek Postula Tags: Review Source Type: research

Epicardial adipose tissue predicts incident cardiovascular disease and mortality in patients with type 2 diabetes
Cardiac fat is a cardiovascular biomarker but its importance in patients with type 2 diabetes is not clear. The aim was to evaluate the predictive potential of epicardial (EAT), pericardial (PAT) and total car... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 30, 2019 Category: Cardiology Authors: Regitse H. Christensen, Bernt Johan von Scholten, Christian S. Hansen, Magnus T. Jensen, Tina Vilsb øll, Peter Rossing and Peter G. Jørgensen Tags: Original investigation Source Type: research

Positive association between baseline brachial –ankle pulse wave velocity and the risk of new-onset diabetes in hypertensive patients
There is no clearly defined temporal relationship between arterial stiffness and diabetes. We aimed to investigate the prospective association between baseline brachial –ankle pulse wave velocity (baPWV) and th... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 28, 2019 Category: Cardiology Authors: Yuanyuan Zhang, Panpan He, Youbao Li, Yan Zhang, Jianping Li, Min Liang, Guobao Wang, Genfu Tang, Yun Song, Binyan Wang, Chengzhang Liu, Lishun Liu, Yimin Cui, Xiaobin Wang, Yong Huo, Xiping Xu & hellip; Tags: Original investigation Source Type: research

Cardiovascular outcomes in trials of new antidiabetic drug classes: a network meta-analysis
Recent trials suggested that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose co-transporter-2 (SGLT-2) inhibitors reduced cardiovascular events. Comparative effectiveness of these new ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 28, 2019 Category: Cardiology Authors: Yue Fei, Man-Fung Tsoi and Bernard Man Yung Cheung Tags: Original investigation Source Type: research

Improved home BP profile with dapagliflozin is associated with amelioration of albuminuria in Japanese patients with diabetic nephropathy: the Yokohama add-on inhibitory efficacy of dapagliflozin on albuminuria in Japanese patients with type 2 diabetes study (Y-AIDA study)
The Y-AIDA study was designed to investigate the renal- and home blood pressure (BP)-modulating effects of add-on dapagliflozin treatment in Japanese individuals with type 2 diabetes mellitus (T2DM) and albumi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 27, 2019 Category: Cardiology Authors: Sho Kinguchi, Hiromichi Wakui, Yuzuru Ito, Yoshinobu Kondo, Kengo Azushima, Uru Osada, Tadashi Yamakawa, Tamio Iwamoto, Jun Yutoh, Toshihiro Misumi, Kazutaka Aoki, Gen Yasuda, Taishi Yoshii, Takayuki Yamada, Syuji Ono, Tomoko Shibasaki-Kurita & hellip; Tags: Original investigation Source Type: research

Temporal relationship between inflammation and insulin resistance and their joint effect on hyperglycemia: the Bogalusa Heart Study
Inflammation and insulin resistance play crucial roles in the development of type 2 diabetes mellitus (T2DM). We aim to examine the temporal relationship between high-sensitivity C-reactive protein (hsCRP) and... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 23, 2019 Category: Cardiology Authors: Yinkun Yan, Shengxu Li, Yang Liu, Lydia Bazzano, Jiang He, Jie Mi and Wei Chen Tags: Original investigation Source Type: research

Successful revascularization versus medical therapy in diabetic patients with stable right coronary artery chronic total occlusion: a retrospective cohort study
The territory of the right coronary artery (RCA) is smaller than that of the left anterior descending artery. Previous studies have reported conflicting results when considering whether stable RCA-chronic tota... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 21, 2019 Category: Cardiology Authors: Yunfeng Yan, Mingduo Zhang, Fei Yuan, Hong Liu, Di Wu, Yudong Fan, Xinjing Guo, Feng Xu, Min Zhang, Quanming Zhao and Shuzheng Lyu Tags: Original investigation Source Type: research

Dapagliflozin improves left ventricular remodeling and aorta sympathetic tone in a pig model of heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction (HFpEF) is a difficult disease with high morbidity and mortality rates and lacks an effective treatment. Here, we report the therapeutic effect of dapagliflozin, ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 20, 2019 Category: Cardiology Authors: Nannan Zhang, Bin Feng, Xuexing Ma, Kangyun Sun, Guidong Xu and Yafeng Zhou Tags: Original investigation Source Type: research

Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study
We investigated the association regarding severe hypoglycemia episodes with cardiovascular disease risk and all-cause mortality in patients with type 2 diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 14, 2019 Category: Cardiology Authors: Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Seon-Ah Cha, Yu-Bae Ahn and Seung-Hyun Ko Tags: Original investigation Source Type: research

High-intensity interval training improves metabolic syndrome and body composition in outpatient cardiac rehabilitation patients with myocardial infarction
To examine the effect of high-intensity interval training (HIIT) on metabolic syndrome (MetS) and body composition in cardiac rehabilitation (CR) patients with myocardial infarction (MI). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 14, 2019 Category: Cardiology Authors: Yaoshan Dun, Randal J. Thomas, Joshua R. Smith, Jose R. Medina-Inojosa, Ray W. Squires, Amanda R. Bonikowske, Hsuhang Huang, Suixin Liu and Thomas P. Olson Tags: Original investigation Source Type: research

The association between serum adiponectin and 3-month outcome after ischemic stroke
Although adiponectin is a major adipocytokine that affects the pathogenesis of various cardiovascular diseases, its clinical significance in stroke remains controversial. The purpose of this study was to asses... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 14, 2019 Category: Cardiology Authors: Zengliang Wang, Bo Li, Yongxin Wang, Aisha Maimaitili, Hu Qin, Geng Dangmurenjiafu and Shuo Wang Tags: Original investigation Source Type: research

Effects of the SGLT2 inhibitor dapagliflozin on cardiac function evaluated by impedance cardiography in patients with type 2 diabetes. Secondary analysis of a randomized placebo-controlled trial
Cardiovascular outcome trials have documented a strong benefit of sodium glucose cotransporter-2 inhibitors (SGLT2i) on the risk of hospitalization for heart failure (HF) in patients with type 2 diabetes (T2D)... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 14, 2019 Category: Cardiology Authors: Benedetta Maria Bonora, Saula Vigili de Kreutzenberg, Angelo Avogaro and Gian Paolo Fadini Tags: Original investigation Source Type: research

A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with myocardial infarction in type 2 diabetic patients
Myocardial infarction is the main mortality cause in patients with type 2 diabetes (T2DM). Endothelial dysfunction due to reduced bioavailability of nitric oxide (NO) is an early step of atherogenesis. Asymmet... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 13, 2019 Category: Cardiology Authors: Gaia Chiara Mannino, Serena Pezzilli, Carolina Averta, Anastasia Fuoco, Rosangela Spiga, Elettra Mancuso, Concetta Di Fatta, Francesco Perticone, Sabrina Prudente, Vincenzo Trischitta, Francesco Andreozzi and Giorgio Sesti Tags: Original investigation Source Type: research

Correction to: Effect of liraglutide on cardiac function in patients with type 2 diabetes mellitus: randomized placebo-controlled trial
Following publication of the original article [1], the authors reported an error in Fig. 3. The bars in the upper right panel that represent heart rate in placebo treated patients is not correct. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 9, 2019 Category: Cardiology Authors: Maurice B. Bizino, Ingrid M. Jazet, Jos J. M. Westenberg, Huub J. van Eyk, Elisabeth H. M. Paiman, Jan W. A. Smit and Hildebrandus J. Lamb Tags: Correction Source Type: research

Insulin resistance and dysglycemia are associated with left ventricular remodeling after myocardial infarction in non-diabetic patients
Adverse cardiac remodeling after ST-segment elevation myocardial infarction (STEMI) is a major cause for poor cardiovascular outcomes such as heart failure. The predisposing factors and underlying mechanisms r... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 7, 2019 Category: Cardiology Authors: Chen Die Yang, Ying Shen, Lin Lu, Feng Hua Ding, Zhen Kun Yang, Rui Yan Zhang, Wei Feng Shen, Wei Jin and Xiao Qun Wang Tags: Original investigation Source Type: research

Class effects of SGLT2 inhibitors on cardiorenal outcomes
To summarize the four recent sodium-glucose cotransporter 2 inhibitor (SGLT2i) trials: Dapagliflozin Effect on CardiovascuLAR Events (DECLARE-TIMI 58), CANagliflozin CardioVascular Assessment Study (CANVAS) Pr... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 5, 2019 Category: Cardiology Authors: Aaron Y. Kluger, Kristen M. Tecson, Andy Y. Lee, Edgar V. Lerma, Janani Rangaswami, Norman E. Lepor, Michael E. Cobble and Peter A. McCullough Tags: Review Source Type: research

Changes in behaviors after diagnosis of type 2 diabetes and 10-year incidence of cardiovascular disease and mortality
Large changes in health behaviors achieved through intensive lifestyle intervention programs improve cardiovascular disease (CVD) risk factors among adults with type 2 diabetes. However, such interventions are... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 1, 2019 Category: Cardiology Authors: Jean Strelitz, Amy L. Ahern, Gr áinne H. Long, Clare E. Boothby, Nicholas J. Wareham and Simon J. Griffin Tags: Original investigation Source Type: research

Novel associations between sex hormones and diabetic vascular complications in men and postmenopausal women: a cross-sectional study
Associations between sex hormones and vascular remodeling have been extensively studied, but the results vary widely among different races and sex. We aimed to investigate whether total testosterone (TT), estr... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 31, 2019 Category: Cardiology Authors: Chiyu Wang, Wen Zhang, Yuying Wang, Heng Wan, Yi Chen, Fangzhen Xia, Kun Zhang, Ningjian Wang and Yingli Lu Tags: Original investigation Source Type: research

Effect of metformin on all-cause and cardiovascular mortality in patients with coronary artery diseases: a systematic review and an updated meta-analysis
Metformin is the most widely prescribed drug to lower glucose and has a definitive effect on the cardiovascular system. The goal of this systematic review and meta-analysis is to assess the effects of metformi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 30, 2019 Category: Cardiology Authors: Yechen Han, Hongzhi Xie, Yongtai Liu, Peng Gao, Xufei Yang and Zhujun Shen Tags: Original investigation Source Type: research

Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai Study
It has been reported that the triglyceride-glucose (TyG) index may serve as a simple and credible surrogate marker of insulin resistance (IR). However, its association with macrovascular and microvascular dama... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 25, 2019 Category: Cardiology Authors: Song Zhao, Shikai Yu, Chen Chi, Ximin Fan, Jiamin Tang, Hongwei Ji, Jiadela Teliewubai, Yi Zhang and Yawei Xu Tags: Original investigation Source Type: research

Class effect for SGLT-2 inhibitors: a tale of 9 drugs
The definition of class effect for SGLT-2 inhibitors may be based on three concepts: a similar chemical structure, a similar mechanism of action and similar pharmacological effects. We have also assumed that a... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 23, 2019 Category: Cardiology Authors: Dario Giugliano and Katherine Esposito Tags: Commentary Source Type: research

Subclinical atherosclerosis burden predicts cardiovascular events in individuals with diabetes and chronic kidney disease
Individuals with diabetes have remarkably high rates of cardiovascular morbidity and mortality. However, the incremental cardiovascular risk in diabetes is heterogeneous and has often been related to renal inv... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 19, 2019 Category: Cardiology Authors: Ana Palanca, Esmeralda Castelblanco, Àngels Betriu, Hèctor Perpiñán, Berta Soldevila, José Manuel Valdivielso, Marcelino Bermúdez-Lopez, Carlos Puig-Jové, Manel Puig-Domingo, Per-Henrik Groop, Elvira Fernández, Núria Alonso and Didac Mauricio Tags: Original investigation Source Type: research

Depressed systemic arterial compliance and impaired left ventricular midwall performance in aortic stenosis with concomitant type 2 diabetes: a retrospective cross-sectional study
Degenerative aortic stenosis (AS), a disease of the elderly, frequently coexists with concomitant diseases, including type 2 diabetes (T2DM) which amplifies the cardiovascular (CV) risk. T2DM affects left vent... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 17, 2019 Category: Cardiology Authors: Ewa Czestkowska, Agnieszka Ro żanowska, Dorota Długosz, Klaudiusz Bolt, Jolanta Świerszcz, Olga Kruszelnicka, Bernadeta Chyrchel and Andrzej Surdacki Tags: Original investigation Source Type: research

GLP-1 secretion in acute ischemic stroke: association with functional outcome and comparison with healthy individuals
Glucagon-like peptide-1 (GLP-1) treatment has been shown to reduce stroke incidence in diabetes and also to be neuroprotective in experimental stroke models. The prognostic value of endogenous levels of GLP-1 ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 15, 2019 Category: Cardiology Authors: Martin Larsson, Cesare Patrone, Mia von Euler, Jens J. Holst and David Nathanson Tags: Original investigation Source Type: research

Carotid ultrasound investigation as a prognostic tool for patients with diabetes mellitus
Experimental and clinical data indicate a major influence of diabetes on atherogenesis. We aimed to assess whether the effect of diabetes on long-term mortality in asymptomatic patient with carotid stenosis is... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 12, 2019 Category: Cardiology Authors: Matthias Hoke, Martin Schillinger, Erich Minar, Georg Goliasch, Christoph J. Binder and Florian J. Mayer Tags: Original investigation Source Type: research

Triglyceride-glucose index is associated with symptomatic coronary artery disease in patients in secondary care
The triglyceride-glucose index (TyG index) is a tool for insulin resistance evaluation, however, little is known about its association with coronary artery disease (CAD), which is the major cardiovascular deat... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 11, 2019 Category: Cardiology Authors: Alessandra da Silva, Ana Paula Silva Caldas, Helen Hermana Miranda Hermsdorff, Ângela Cristine Bersch-Ferreira, Camila Ragne Torreglosa, Bernardete Weber and Josefina Bressan Tags: Original investigation Source Type: research

A double-blind, placebo-controlled, randomised trial to assess the effect of liraglutide on ectopic fat accumulation in South Asian type 2 diabetes patients
South Asians have a high risk to develop type 2 diabetes, which may be related to substantial ectopic fat deposition. Since glucagon-like peptide-1 analogues can reduce ectopic fat accumulation, the aim of the... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 9, 2019 Category: Cardiology Authors: Huub J. van Eyk, Elisabeth H. M. Paiman, Maurice B. Bizino, Paul de Heer, Petronella H. Geelhoed-Duijvestijn, Aan V. Kharagjitsingh, Johannes W. A. Smit, Hildo J. Lamb, Patrick C. N. Rensen and Ingrid M. Jazet Tags: Original investigation Source Type: research

The role of blood pressure in risk of ischemic and hemorrhagic stroke in type 1 diabetes
Hypertension is one of the strongest risk factors for stroke in the general population, while systolic blood pressure has been shown to independently increase the risk of stroke in type 1 diabetes. The aim of ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 9, 2019 Category: Cardiology Authors: Stefanie H ägg-Holmberg, Emma H. Dahlström, Carol M. Forsblom, Valma Harjutsalo, Ron Liebkind, Jukka Putaala, Turgut Tatlisumak, Per-Henrik Groop and Lena M. Thorn Tags: Original investigation Source Type: research

Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure
Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA accumulation occurs in patients with dil... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 5, 2019 Category: Cardiology Authors: Golam M. Uddin, Liyan Zhang, Saumya Shah, Arata Fukushima, Cory S. Wagg, Keshav Gopal, Rami Al Batran, Simran Pherwani, Kim L. Ho, Jamie Boisvenue, Qutuba G. Karwi, Tariq Altamimi, David S. Wishart, Jason R. B. Dyck, John R. Ussher, Gavin Y. Oudit & helli Tags: Original investigation Source Type: research