The sweet spot: fasting glucose, cardiovascular disease, and mortality in older adults with diabetes: a nationwide population-based study
Growing evidences shows that fasting glucose target should be different according to their health condition in older adults with diabetes. However, there are limited data regarding the relationship between fas... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 1, 2020 Category: Cardiology Authors: Ji Hyun Lee, Kyungdo Han and Ji Hye Huh Tags: Original investigation Source Type: research

Retinopathy predicts stroke but not myocardial infarction in type 2 diabetes: the Fremantle Diabetes Study Phase II
Microangiopathy in type 2 diabetes (T2D) is associated with cardiovascular disease (CVD), but most relevant studies were performed  > 10 years ago. CVD risk factor management has since improved. The aim of this... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 31, 2020 Category: Cardiology Authors: Jocelyn J. Drinkwater, Timothy M. E. Davis, Valentina Hellbusch, Angus W. Turner, David G. Bruce and Wendy A. Davis Tags: Original investigation Source Type: research

Cardiac magnetic resonance for asymptomatic patients with type 2 diabetes and cardiovascular high risk (CATCH): a pilot study
Stress cardiovascular magnetic resonance (CMR) to screen for silent myocardial ischaemia in asymptomatic high risk patients with type 2 diabetes mellitus (DM) has never been performed, and its effectiveness is... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 31, 2020 Category: Cardiology Authors: Ming-Yen Ng, Wenli Zhou, Varut Vardhanabhuti, Chi-Ho Lee, Esther Yee Tak Yu, Eric Yuk Fai Wan, Kit Chan, Andrew T. Yan, Tai-Pang Ip, Kai-Hang Yiu and Bernd J. Wintersperger Tags: Original investigation Source Type: research

Change in glucose intolerance status and risk of incident cardiovascular disease: Tehran Lipid and Glucose Study
To assess the impact of changes in different glucose tolerance states on risk of incident cardiovascular disease (CVD)/coronary heart disease (CHD). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 30, 2020 Category: Cardiology Authors: Maryam Kabootari, Mitra Hasheminia, Fereidoun Azizi, Mohammadhassan Mirbolouk and Farzad Hadaegh Tags: Original investigation Source Type: research

The association between serum growth differentiation factor 15 levels and lower extremity atherosclerotic disease is independent of body mass index in type 2 diabetes
Clinical and basic investigations have indicated a significant association between circulating growth differentiation factor 15 (GDF15) and cardiovascular disease; however, the relationship between GDF15 and l... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 28, 2020 Category: Cardiology Authors: Xingxing He, Jiaorong Su, Xiaojing Ma, Wei Lu, Wei Zhu, Yufei Wang, Yuqian Bao and Jian Zhou Tags: Original investigation Source Type: research

Waist circumference is associated with major adverse cardiovascular events in male but not female patients with type-2 diabetes mellitus
Although studies have shown that waist circumference (WC) is positively associated with an increased risk of cardiovascular diseases among the normal population, few studies have investigated WC in patients wi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 25, 2020 Category: Cardiology Authors: Zhenhua Xing, Zhenyu Peng, Xiaopu Wang, Zhaowei Zhu, Junyu Pei, Xinqun Hu and Xiangping Chai Tags: Original investigation Source Type: research

Long-term LVEF trajectories in patients with type 2 diabetes and heart failure: diabetic cardiomyopathy may underlie functional decline
Left ventricular ejection fraction (LVEF) trajectories and functional recovery with current heart failure (HF) management is increasingly recognized. Type 2 diabetes mellitus (T2D) leads to a worse prognosis i... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 23, 2020 Category: Cardiology Authors: Mar ía Teresa Julián, Núria Alonso, Josep Lupón, Giovana Gavidia-Bovadilla, Elena Ferrer, Marta de Antonio, Jorge López-Ayerbe, Mar Domingo, Evelyn Santiago-Vacas, Elisabet Zamora, Pau Codina, Pedro Moliner, Julio Núñez, Javier Santesmases, Manel P Tags: Original investigation Source Type: research

Preventing major adverse cardiovascular events by SGLT-2 inhibition in patients with type 2 diabetes: the role of kidney
Cardiovascular outcome trials (CVOTs) have demonstrated a significant reduction of major adverse cardiovascular events (MACE) in patients with type 2 diabetes (T2D) treated by SGLT-2 inhibitors. This holds tru... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 19, 2020 Category: Cardiology Authors: Dario Giugliano, Luca De Nicola, Maria Ida Maiorino, Giuseppe Bellastella, Carlo Garofalo, Paolo Chiodini, Antonio Ceriello and Katherine Esposito Tags: Commentary Source Type: research

Fibrinogen is associated with glucose metabolism and cardiovascular outcomes in patients with coronary artery disease
The present cohort study aims to examine the relationship between fibrinogen (Fib) levels and glucose metabolism [fasting blood glucose (FBG) and hemoglobin A1c (HbA1c)] and investigate the impact of high Fib ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 19, 2020 Category: Cardiology Authors: Shuo-Lin Liu, Na-Qiong Wu, Hui-Wei Shi, Qian Dong, Qiu-ting Dong, Ying Gao, Yuan-Lin Guo and Jian-Jun Li Tags: Original investigation Source Type: research

Clinical outcomes after cardiac rehabilitation in elderly patients with and without diabetes mellitus: The EU-CaRE multicenter cohort study
The prevalence of patients with concomitant cardiovascular disease and diabetes mellitus (DM) is increasing rapidly. We aimed to compare the effectiveness of current cardiac rehabilitation (CR) programs across... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 19, 2020 Category: Cardiology Authors: Prisca Eser, Thimo Marcin, Eva Prescott, Leonie F. Prins, Evelien Kolkman, Wendy Bruins, Astrid E. van der Velde, Carlos Pe ña-Gil, Marie-Christine Iliou, Diego Ardissino, Uwe Zeymer, Esther P. Meindersma, Arnoud. W. J. Van’tHof, Ed P. de Kluiver, Mark Tags: Original investigation Source Type: research

Triglyceride glucose index is an independent predictor for the progression of coronary artery calcification in the absence of heavy coronary artery calcification at baseline
Data on the relationship between the triglyceride glucose (TyG) index and coronary artery calcification (CAC) progression is limited. This longitudinal study evaluated the association of TyG index with CAC pro... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 16, 2020 Category: Cardiology Authors: Ki-Bum Won, Eun Ji Park, Donghee Han, Ji Hyun Lee, Su-Yeon Choi, Eun Ju Chun, Sung Hak Park, Hae-Won Han, Jidong Sung, Hae Ok Jung and Hyuk-Jae Chang Tags: Original investigation Source Type: research

Research progress on alternative non-classical mechanisms of PCSK9 in atherosclerosis in patients with and without diabetes
The proprotein convertase subtilisin/kexin type 9 (PCSK9) acts via a canonical pathway to regulate circulating low-density lipoprotein-cholesterol (LDL-C) via degradation of the LDL receptor (LDLR) on the live... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 13, 2020 Category: Cardiology Authors: Ying Tang, Sheng-Lan Li, Jia-Hui Hu, Kai-Jun Sun, Lei-Ling Liu and Dan-Yan Xu Tags: Review Source Type: research

Biomarker-defined pathways for incident type 2 diabetes and coronary heart disease —a comparison in the MONICA/KORA study
Biomarkers may contribute to our understanding of the pathophysiology of various diseases. Type 2 diabetes (T2D) and coronary heart disease (CHD) share many clinical and lifestyle risk factors and several biom... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 12, 2020 Category: Cardiology Authors: Cornelia Huth, Alina Bauer, Astrid Zierer, Julie Sudduth-Klinger, Christa Meisinger, Michael Roden, Annette Peters, Wolfgang Koenig, Christian Herder and Barbara Thorand Tags: Original investigation Source Type: research

Empagliflozin improves cardiac function in heart failure with reduced ejection fraction independent of loading conditions
The study regarding load-independent effects of empagliflozin contribute to improved cardiac function in experimental heart failure with reduced ejection fraction is very interesting. But there are a few thing... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 10, 2020 Category: Cardiology Authors: Bo Liang, Yu-Xiu Zhao and Ning Gu Tags: Commentary Source Type: research

Glycemic status and risks of thromboembolism and major bleeding in patients with atrial fibrillation
Studies specifically examining the association between glycated hemoglobin A1c (HbA1c) levels and ischemic stroke/systemic thromboembolism (IS/SE) risk in atrial fibrillation (AF) patients are limited. Here, w... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 10, 2020 Category: Cardiology Authors: Yi-Hsin Chan, Chi Chuang, Cze-Ci Chan, Hsin-Fu Lee, Ya-Chi Huang, Yu-Tung Huang, Shang-Hung Chang, Chun-Li Wang, Tze-Fan Chao, Chi-Tai Kuo, Yung-Hsin Yeh and Shih-Ann Chen Tags: Original investigation Source Type: research

Triglyceride glucose index for predicting cardiovascular outcomes after percutaneous coronary intervention in patients with type 2 diabetes mellitus and acute coronary syndrome
The triglyceride glucose (TyG) index, a simple surrogate estimate of insulin resistance, has been demonstrated to predict cardiovascular (CV) disease morbidity and mortality in the general population and many ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 10, 2020 Category: Cardiology Authors: Xiaoteng Ma, Lisha Dong, Qiaoyu Shao, Yujing Cheng, Sai Lv, Yan Sun, Hua Shen, Zhijian Wang, Yujie Zhou and Xiaoli Liu Tags: Original investigation Source Type: research

Legacy effect of fibrate add-on therapy in diabetic patients with dyslipidemia: a secondary analysis of the ACCORDION study
The Action to Control Cardiovascular Risk in Diabetes (ACCORD)-Lipid study found no evidence of a beneficial effect of statin-fibrate combined treatment, compared to statins alone, on cardiovascular outcomes a... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 5, 2020 Category: Cardiology Authors: Lin Zhu, Andrew Hayen and Katy J. L. Bell Tags: Original investigation Source Type: research

The pro-inflammatory marker soluble suppression of tumorigenicity-2 (ST2) is reduced especially in diabetic morbidly obese patients undergoing bariatric surgery
High soluble suppression of tumorigenicity-2 (sST2) is a marker of poor prognosis in chronic inflammatory conditions. ST2 and its ligand interleukin (IL)-33 are elevated in adipose tissue of obese individuals.... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 26, 2020 Category: Cardiology Authors: Svitlana Demyanets, Christoph Kaun, Alexandra Kaider, Walter Speidl, Manfred Prager, Stanislav Oravec, Philipp Hohensinner, Johann Wojta and Gersina Rega-Kaun Tags: Original investigation Source Type: research

The risk of sudden cardiac arrest and ventricular arrhythmia with rosiglitazone versus pioglitazone: real-world evidence on thiazolidinedione safety
The low cost of thiazolidinediones makes them a potentially valuable therapeutic option for the  > 300 million economically disadvantaged persons worldwide with type 2 diabetes mellitus. Differential selectivit... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 25, 2020 Category: Cardiology Authors: Charles E. Leonard, Colleen M. Brensinger, Ghadeer K. Dawwas, Rajat Deo, Warren B. Bilker, Samantha E. Soprano, Neil Dhopeshwarkar, James H. Flory, Zachary T. Bloomgarden, Joshua J. Gagne, Christina L. Aquilante, Stephen E. Kimmel and Sean Hennessy Tags: Original investigation Source Type: research

Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet
Obesity, hypertension and prediabetes contribute greatly to coronary artery disease, heart failure and vascular events, and are the leading cause of mortality and morbidity in developed societies. Salt sensiti... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 24, 2020 Category: Cardiology Authors: Vijayakumar Sukumaran, Hirotsugu Tsuchimochi, Takashi Sonobe, Mark T. Waddingham, Mikiyasu Shirai and James T. Pearson Tags: Original investigation Source Type: research

The atherogenic index of plasma plays an important role in predicting the prognosis of type 2 diabetic subjects undergoing percutaneous coronary intervention: results from an observational cohort study in China
Many studies have reported the predictive value of the atherogenic index of plasma (AIP) in the progression of atherosclerosis and the prognosis of percutaneous coronary intervention (PCI). However, the utilit... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 21, 2020 Category: Cardiology Authors: Zheng Qin, Kuo Zhou, Yueping Li, Wanjun Cheng, Zhijian Wang, Jianlong Wang, Fei Gao, Lixia Yang, Yingkai Xu, Yafeng Wu, Hua He and Yujie Zhou Tags: Original investigation Source Type: research

Mitochondrial 8-hydroxy-2 ′-deoxyguanosine and coronary artery disease in patients with type 2 diabetes mellitus
Little is known about whether mitochondria 8-hydroxy-2 ′-deoxyguanosine (8-OHdG), a biomarker of mitochondrial DNA (mtDNA) oxidative damage, contributes to the development of coronary artery disease (CAD) in di... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 19, 2020 Category: Cardiology Authors: Xue-bin Wang, Ning-hua Cui, Xia ’nan Liu and Xin Liu Tags: Original investigation Source Type: research

Empagliflozin improved systolic blood pressure, endothelial dysfunction and heart remodeling in the metabolic syndrome ZSF1 rat
Empagliflozin (empa), a selective sodium –glucose cotransporter (SGLT)2 inhibitor, reduced cardiovascular mortality and hospitalization for heart failure in patients with type 2 diabetes at high cardiovascular ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 18, 2020 Category: Cardiology Authors: Sin-Hee Park, Muhammad Akmal Farooq, S ébastien Gaertner, Christophe Bruckert, Abdul Wahid Qureshi, Hyun-Ho Lee, Djamel Benrahla, Brigitte Pollet, Dominique Stephan, Patrick Ohlmann, Jean-Marc Lessinger, Eric Mayoux, Cyril Auger, Olivier Morel and Valér Tags: Original investigation Source Type: research

Increased risk of cardiovascular mortality by strict glycemic control (pre-procedural HbA1c   <  6.5%) in Japanese medically-treated diabetic patients following percutaneous coronary intervention: a 10-year follow-up study
In the secondary prevention of cardiovascular (CV) disease in patients with diabetes, an optimal level of HbA1c, the most widely-used glycemic control indicator, for favorable clinical consequences still remai... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 18, 2020 Category: Cardiology Authors: Takehiro Funamizu, Hiroshi Iwata, Yuya Nishida, Katsutoshi Miyosawa, Shinichiro Doi, Yuichi Chikata, Jun Shitara, Hirohisa Endo, Hideki Wada, Ryo Naito, Manabu Ogita, Tomotaka Dohi, Takatoshi Kasai, Shinya Okazaki, Kikuo Isoda, Katsumi Miyauchi & hellip; Tags: Original investigation Source Type: research

Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes
Diabetes mellitus is characterized by chronic vascular inflammation leading to pathological expression of the thrombogenic full length (fl) tissue factor (TF) and its isoform alternatively-spliced (as) TF. Blo... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 17, 2020 Category: Cardiology Authors: Marco Witkowski, Mario Witkowski, Mona Saffarzadeh, Julian Friebel, Termeh Tabaraie, Loc Ta Bao, Aritra Chakraborty, Andrea D örner, Bernd Stratmann, Diethelm Tschoepe, Samantha J. Winter, Andreas Krueger, Wolfram Ruf, Ulf Landmesser and Ursula Rauch Tags: Original investigation Source Type: research

Favorable pleiotropic effects of sodium glucose cotransporter 2 inhibitors: head-to-head comparisons with dipeptidyl peptidase-4 inhibitors in type 2 diabetes patients
Sodium glucose cotransporter 2 (SGLT2) inhibitors have shown greater reductions of cardiovascular event risks than dipeptidyl peptidase-4 (DPP4) inhibitors, whereby possible mechanisms may involve the better p... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 12, 2020 Category: Cardiology Authors: Shih-Chieh Shao, Kai-Cheng Chang, Swu-Jane Lin, Rong-Nan Chien, Ming-Jui Hung, Yuk-Ying Chan, Yea-Huei Kao Yang and Edward Chia-Cheng Lai Tags: Original investigation Source Type: research

Prognostic utility of heart-type fatty acid-binding protein in patients with stable coronary artery disease and impaired glucose metabolism: a cohort study
Heart-type fatty acid-binding protein (H-FABP) is a novel marker of myocardial injury and has been reported to be associated with cardiovascular diseases (CVD) including patients with diabetes mellitus (DM). U... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 10, 2020 Category: Cardiology Authors: Hui-Wen Zhang, Jing-Lu Jin, Ye-Xuan Cao, Hui-Hui Liu, Yan Zhang, Yuan-Lin Guo, Na-Qiong Wu, Ying Gao, Rui-Xia Xu, Qi Hua, Yan-Fang Li, Chuan-Jue Cui, Geng Liu, Qian Dong, Jing Sun and Jian-Jun Li Tags: Original investigation Source Type: research

Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes
Cardiac adipose tissue may have local paracrine effects on epicardial arteries and the underlying myocardium, promoting calcification and affecting myocardial microcirculation. We explored whether the total am... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 10, 2020 Category: Cardiology Authors: Emilie H. Zobel, Regitse H øjgaard Christensen, Signe A. Winther, Philip Hasbak, Christian Stevns Hansen, Bernt J. von Scholten, Lene Holmvang, Andreas Kjaer, Peter Rossing and Tine W. Hansen Tags: Original investigation Source Type: research

Load-independent effects of empagliflozin contribute to improved cardiac function in experimental heart failure with reduced ejection fraction
Sodium –glucose linked cotransporter-2 (SGLT2) inhibitors reduce the likelihood of hospitalization for heart failure and cardiovascular death in both diabetic and non-diabetic individuals with reduced ejection ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 8, 2020 Category: Cardiology Authors: Kim A. Connelly, Yanling Zhang, Jean-Fran çois Desjardins, Linda Nghiem, Aylin Visram, Sri N. Batchu, Verra G. Yerra, Golam Kabir, Kerri Thai, Andrew Advani and Richard E. Gilbert Tags: Original investigation Source Type: research

Effect of alirocumab on individuals with type 2 diabetes, high triglycerides, and low high-density lipoprotein cholesterol
Mixed dyslipidemia [elevated non-high-density lipoprotein cholesterol (non-HDL-C) and triglycerides (TGs), and decreased HDL-C] is common in type 2 diabetes mellitus (T2DM) and is associated with increased car... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 8, 2020 Category: Cardiology Authors: Helen M. Colhoun, Lawrence A. Leiter, Dirk M üller-Wieland, Bertrand Cariou, Kausik K. Ray, Francisco J. Tinahones, Catherine Domenger, Alexia Letierce, Marc Israel, Rita Samuel and Stefano Del Prato Tags: Original investigation Source Type: research

Polygenic risk for coronary heart disease acts through atherosclerosis in type 2 diabetes
Type 2 diabetes increases the risk of coronary heart disease (CHD), yet the mechanisms involved remain poorly described. Polygenic risk scores (PRS) provide an opportunity to understand risk factors since they... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 30, 2020 Category: Cardiology Authors: Tianyuan Lu, Vincenzo Forgetta, Oriana H. Y. Yu, Lauren Mokry, Madeline Gregory, George Thanassoulis, Celia M. T. Greenwood and J. Brent Richards Tags: Original investigation Source Type: research

Association of insulin resistance, from mid-life to late-life, with aortic stiffness in late-life: the Atherosclerosis Risk in Communities Study
We examined the cross-sectional association and prospective association of insulin resistance and aortic stiffness in olde... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 28, 2020 Category: Cardiology Authors: Anna K. Poon, Michelle L. Meyer, Hirofumi Tanaka, Elizabeth Selvin, James Pankow, Donglin Zeng, Laura Loehr, Joshua W. Knowles, Wayne Rosamond and Gerardo Heiss Tags: Original investigation Source Type: research

Effects of antidiabetic drugs on left ventricular function/dysfunction: a systematic review and network meta-analysis
Although a variety of antidiabetic drugs have significant protective action on the cardiovascular system, it is still unclear which antidiabetic drugs can improve ventricular remodeling and fundamentally delay... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 22, 2020 Category: Cardiology Authors: Da-Peng Zhang, Li Xu, Le-Feng Wang, Hong-Jiang Wang and Feng Jiang Tags: Original investigation Source Type: research

Risk of atrial fibrillation in persons with type 2 diabetes and the excess risk in relation to glycaemic control and renal function: a Swedish cohort study
To examine the incidence of atrial fibrillation in individuals with type 2 diabetes compared with age- and sex-matched controls from the general population and its variation in relation to glycaemic control an... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 18, 2020 Category: Cardiology Authors: Shilan Seyed Ahmadi, Ann-Marie Svensson, Aldina Pivodic, Annika Rosengren and Marcus Lind Tags: Original investigation Source Type: research

Use of the triglyceride-glucose index (TyG) in cardiovascular disease patients
Da Silva et al. showed that the triglyceride-glucose (TyG) index was positively associated with a higher prevalence of symptomatic coronary artery disease (CAD). TyG has been used in healthy individuals as a m... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 15, 2020 Category: Cardiology Authors: Javad Alizargar, Chyi-Huey Bai, Nan-Chen Hsieh and Shu-Fang Vivienne Wu Tags: Commentary Source Type: research

Sodium –glucose cotransporter 2 inhibitor Dapagliflozin attenuates diabetic cardiomyopathy
Diabetes mellitus type 2 (DM2) is a risk factor for developing heart failure but there is no specific therapy for diabetic heart disease. Sodium glucose transporter 2 inhibitors (SGLT2I) are recently developed... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 10, 2020 Category: Cardiology Authors: M. Arow, M. Waldman, D. Yadin, V. Nudelman, A. Shainberg, N. G. Abraham, D. Freimark, R. Kornowski, D. Aravot, E. Hochhauser and M. Arad Tags: Original investigation Source Type: research

Positive effect of dapagliflozin on left ventricular longitudinal function for type 2 diabetic mellitus patients with chronic heart failure
The effect of sodium glucose cotransporter type 2 (SGLT2) inhibitor on left ventricular (LV) longitudinal myocardial function in type 2 diabetes mellitus (T2DM) patients with heart failure (HF) has remained un... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 7, 2020 Category: Cardiology Authors: Hidekazu Tanaka, Fumitaka Soga, Kazuhiro Tatsumi, Yasuhide Mochizuki, Hiroyuki Sano, Hiromi Toki, Kensuke Matsumoto, Junya Shite, Hideyuki Takaoka, Tomofumi Doi and Ken-ichi Hirata Tags: Original investigation Source Type: research

Efficacy of dapagliflozin versus sitagliptin on cardiometabolic risk factors in Japanese patients with type 2 diabetes: a prospective, randomized study (DIVERSITY-CVR)
Few prospective studies have compared the cardiovascular benefits of sodium-glucose cotransporter-2 (SGLT2) inhibitors and dipeptidyl peptidase 4 (DPP-4) inhibitors. We aimed to clarify the efficacy of dapagli... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 7, 2020 Category: Cardiology Authors: Ayako Fuchigami, Fumika Shigiyama, Toru Kitazawa, Yosuke Okada, Takamasa Ichijo, Mariko Higa, Toru Hiyoshi, Ikuo Inoue, Kaoru Iso, Hidenori Yoshii, Takahisa Hirose and Naoki Kumashiro Tags: Original investigation Source Type: research

Pioglitazone and PPAR- γ modulating treatment in hypertensive and type 2 diabetic patients after ischemic stroke: a national cohort study
Peroxisome proliferator-activated receptor- γ (PPAR-γ) modulating treatment may have cardiovascular benefits in type 2 diabetes mellitus (T2DM) patients after ischemic stroke (IS). However, whether there are ad... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 7, 2020 Category: Cardiology Authors: Chi-Hung Liu, Tsong-Hai Lee, Yu-Sheng Lin, Pi-Shan Sung, Yi-Chia Wei and Yan-Rong Li Tags: Original investigation Source Type: research

Aspirin, clopidogrel and prasugrel monotherapy in patients with type 2 diabetes mellitus: a double-blind randomised controlled trial of the effects on thrombotic markers and microRNA levels
Despite increased atherothrombotic risk in type 2 diabetes mellitus, (T2DM) the best preventative antithrombotic strategy remains undetermined. We defined the effects of three antiplatelet agents on functional... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 7, 2020 Category: Cardiology Authors: William A. E. Parker, Christian Schulte, Temo Barwari, Fladia Phoenix, Sam M. Pearson, Manuel Mayr, Peter J. Grant, Robert F. Storey and Ramzi A. Ajjan Tags: Original investigation Source Type: research

Fasting plasma glucose variability and HbA1c are associated with peripheral artery disease risk in type 2 diabetes
This study investigated whether visit-to-visit fasting plasma glucose (FPG) variability, as measured by the coefficient of variation (CV), increased peripheral artery disease (PAD) risk. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 7, 2020 Category: Cardiology Authors: Chun-Pai Yang, Cheng-Chieh Lin, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Kai-Lin Hwang, Shing-Yu Yang and Tsai-Chung Li Tags: Original investigation Source Type: research

Sodium-glucose co-transporter 2 inhibition as a mitochondrial therapy for atrial fibrillation in patients with diabetes?
While patients with type 2 diabetes mellitus (T2DM) are at increased risk to develop atrial fibrillation (AF), the mechanistic link between T2DM and AF-susceptibility remains unclear. Common co-morbidities of ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 7, 2020 Category: Cardiology Authors: Salva R. Yurista, Herman H. W. Sillj é, Michiel Rienstra, Rudolf A. de Boer and B. Daan Westenbrink Tags: Commentary Source Type: research

Impaired myocardial deformation and ventricular vascular coupling in obese adolescents with dysglycemia
It is unknown that dysglycemia in obese adolescents has effects on myocardial deformation that are more pronounced when compared to obesity alone. We hypothesized that obesity associated abnormal glucose toler... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 19, 2019 Category: Cardiology Authors: Preneet Cheema Brar, Anne Chun, Xiazhou Fan, Vivek Jani, Mary Craft, Puneet Bhatla and Shelby Kutty Tags: Original investigation Source Type: research

High-sensitivity troponin I and B-type natriuretic peptide biomarkers for prediction of cardiovascular events in patients with coronary artery disease with and without diabetes mellitus
High-sensitivity troponin I (hs-Tnl) and B-type natriuretic peptide (BNP) are promising prognostic markers for coronary artery disease (CAD). This prospective cohort study investigated whether a combination of... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 17, 2019 Category: Cardiology Authors: Yuen-Kwun Wong, Chloe Y. Y. Cheung, Clara S. Tang, JoJo S. H. Hai, Chi-Ho Lee, Kui-Kai Lau, Ka-Wing Au, Bernard M. Y. Cheung, Pak-Chung Sham, Aimin Xu, Karen S. L. Lam and Hung-Fat Tse Tags: Original investigation Source Type: research

Visit-to-visit variability of glycemia and vascular complications: the Hoorn Diabetes Care System cohort
Glycemic variation has been suggested to be a risk factor for diabetes-related complications. Previous studies did not address confounding of diabetes duration, number of visits and length of follow-up. Here, ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 12, 2019 Category: Cardiology Authors: Roderick C. Slieker, Amber A. W. H. van der Heijden, Giel Nijpels, Petra J. M. Elders, Leen M. ’t Hart and Joline W. J. Beulens Tags: Original investigation Source Type: research

Prognostic value of HbA1c for in-hospital and short-term mortality in patients with acute coronary syndrome: a systematic review and meta-analysis
HbA1c, the most commonly used indicator of chronic glucose metabolism, is closely associated with cardiovascular disease. However, the relationship between HbA1c and the mortality of acute coronary syndrome (A... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 11, 2019 Category: Cardiology Authors: Wenjun Pan, Haining Lu, Baotao Lian, Pengda Liao, Liheng Guo and Minzhou Zhang Tags: Review Source Type: research

Metformin use and cardiovascular outcomes after acute myocardial infarction in patients with type 2 diabetes: a cohort study
The use of metformin after acute myocardial infarction (AMI) has been associated with reduced mortality in people with type 2 diabetes mellitus (T2DM). However, it is not known if it is acutely cardioprotectiv... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 9, 2019 Category: Cardiology Authors: Daniel I. Bromage, Tom R. Godec, Mar Pujades-Rodriguez, Arturo Gonzalez-Izquierdo, S. Denaxas, Harry Hemingway and Derek M. Yellon Tags: Original investigation Source Type: research

Association of glycemic variability with left ventricular diastolic function in type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is a major cause of heart failure (HF) with preserved ejection fraction (HFpEF), usually presenting as left ventricular (LV) diastolic dysfunction. Thus, LV diastolic function s... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 5, 2019 Category: Cardiology Authors: Shun Yokota, Hidekazu Tanaka, Yasuhide Mochizuki, Fumitaka Soga, Kentaro Yamashita, Yusuke Tanaka, Ayu Shono, Makiko Suzuki, Keiko Sumimoto, Jun Mukai, Makiko Suto, Hiroki Takada, Kensuke Matsumoto, Yushi Hirota, Wataru Ogawa and Ken-ichi Hirata Tags: Original investigation Source Type: research

Plasma omentin levels are inversely associated with atherosclerosis in type 2 diabetes patients with increased plasma adiponectin levels: a cross-sectional study
Omentin and adiponectin are among the anti-inflammatory and anti-atherogenic adipokines that have potentially beneficial effects on cardiovascular disorders. Recent studies indicate a paradoxical relationship ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 5, 2019 Category: Cardiology Authors: Masami Nishimura, Tomoaki Morioka, Mariko Hayashi, Yoshinori Kakutani, Yuko Yamazaki, Masafumi Kurajoh, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Tetsuo Shoji, Masaaki Inaba and Masanori Emoto Tags: Original investigation Source Type: research

GLP-1 analog liraglutide-induced cardiac dysfunction due to energetic starvation in heart failure with non-diabetic dilated cardiomyopathy
Glucagon-like peptide-1 (GLP-1) reduces cardiovascular events in diabetic patients; however, its counter-protective effects have also been suggested in patients with heart failure and the clear explanation for... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 28, 2019 Category: Cardiology Authors: Aya Shiraki, Jun-ichi Oyama, Toshiyuki Nishikido and Koichi Node Tags: Original investigation Source Type: research