Targeting high glucose-induced epigenetic modifications at cardiac level: the role of SGLT2 and SGLT2 inhibitors
Sodium-glucose co-transporters (SGLT) inhibitors (SGLT2i) showed many beneficial effects at the cardiovascular level. Several mechanisms of action have been identified. However, no data on their capability to ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 2, 2023 Category: Cardiology Authors: Lucia Scisciola, Fatemeh Taktaz, Rosaria Anna Fontanella, Ada Pesapane, Surina, Vittoria Cataldo, Puja Ghosh, Martina Franzese, Armando Puocci, Pasquale Paolisso, Concetta Rafaniello, Raffaele Marfella, Maria Rosaria Rizzo, Emanuele Barbato, Marc Vanderhe Tags: Research Source Type: research

Acid sphingomyelinase promotes diabetic cardiomyopathy via NADPH oxidase 4 mediated apoptosis
Increased acid sphingomyelinase (ASMase) activity is associated with insulin resistance and cardiac dysfunction. However, the effects of ASMase on diabetic cardiomyopathy (DCM) and the molecular mechanism(s) u... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 2, 2023 Category: Cardiology Authors: Ruijiao Liu, Tengfei Duan, Li Yu, Yongzhong Tang, Shikun Liu, Chunjiang Wang and Wei-Jin Fang Tags: Research Source Type: research

Efficacy of cardiometabolic drugs in reduction of epicardial adipose tissue: a systematic review and meta-analysis
Epicardial adipose tissue (EAT) plays an important role in cardiometabolic risk. EAT is a modifiable risk factor and could be a potential therapeutic target for drugs that already show cardiovascular benefits. Th... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 31, 2023 Category: Cardiology Authors: Veronika A. Myasoedova, Valentina Parisi, Donato Moschetta, Vincenza Valerio, Maddalena Conte, Ilaria Massaiu, Michele Bozzi, Fabrizio Celeste, Dario Leosco, Guido Iaccarino, Stefano Genovese and Paolo Poggio Tags: Research Source Type: research

Improved prognosis with integrated care management including early rhythm control and healthy lifestyle modification in patients with concurrent atrial fibrillation and diabetes mellitus: a nationwide cohort study
Patients with concurrent atrial fibrillation (AF) and diabetes mellitus (DM) [AF-DM] have a high risk of cardiovascular and diabetes-related complications, but are less engaged in a comprehensive treatment app... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 30, 2023 Category: Cardiology Authors: So-Ryoung Lee, Hyo-Jeong Ahn, Eue-Keun Choi, Seung-Woo Lee, Kyung-Do Han, Seil Oh and Gregory Y. H. Lip Tags: Research Source Type: research

Sex-specific differences in the effect of the atherogenic index of plasma on prediabetes and diabetes in the NHANES 2011 –2018 population
Although a great deal of scientific evidence on the epidemiological risk factors for diabetes and prediabetes has been accumulated, there is still insufficient evidence to explore sex-related differences. The ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 30, 2023 Category: Cardiology Authors: Yumeng Shi and Minghua Wen Tags: Research Source Type: research

Clinical potential of inclisiran for patients with a high risk of atherosclerotic cardiovascular disease
Elevated low-density lipoprotein cholesterol (LDL-C) level is associated with an increased risk of atherosclerotic cardiovascular disease. Although high-intensity lipid-lowering therapies with statins and ezet... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 30, 2023 Category: Cardiology Authors: Toshiyuki Nishikido Tags: Review Source Type: research

Association between triglyceride-glucose index and risk of cardiovascular disease among postmenopausal women
We aimed to examine the association of triglyceride-glucose index (TyG) with risk for cardiovascular disease (CVD) among postmenopausal women. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 30, 2023 Category: Cardiology Authors: Qian Liu, Fei Si, Zhou Liu, Yuntao Wu and Jing Yu Tags: Research Source Type: research

Outcomes of deferred revascularisation following negative fractional flow reserve in diabetic and non-diabetic patients: a meta-analysis
Fractional Flow Reserve (FFR) is a widely applied invasive physiological assessment, endorsed by major guidelines to aid in the decision to perform or defer revascularisation. While a threshold of  > 0.8 has b... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 30, 2023 Category: Cardiology Authors: Avedis Ekmejian, Hari Sritharan, Dinesh Selvakumar, Venkateshka Venkateshka, Usaid Allahwala, Michael Ward and Ravinay Bhindi Tags: Research Source Type: research

Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia/reperfusion
Type 2 Diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease and associated with poor outcome after myocardial infarction (MI). In T2DM, cardiac metabolic flexibility, i.e. the switch betw... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 27, 2023 Category: Cardiology Authors: C. Binsch, D. M. Barbosa, G. Hansen-Dille, M. Hubert, S. M. Hodge, M. Kolasa, K. Jeruschke, J. Wei ß, C. Springer, S. Gorressen, J. W. Fischer, M. Lienhard, R. Herwig, S. Börno, B. Timmermann, A. L. Cremer & hellip; Tags: Research Source Type: research

The worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T CMR feature tracking study
To explore the additive effects of anemia on left ventricular (LV) global strains in patients with type 2 diabetes mellitus (T2DM) with or without anemia via cardiac magnetic resonance (CMR) feature tracking t... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 24, 2023 Category: Cardiology Authors: Wen-Lei Qian, Rong Xu, Rui Shi, Yuan Li, Ying-Kun Guo, Han Fang, Li jiang and Zhi-Gang Yang Tags: Research Source Type: research

The real-world safety profile of sodium-glucose co-transporter-2 inhibitors among older adults ( ≥ 75 years): a retrospective, pharmacovigilance study
As indications for sodium-glucose co-transporter-2 inhibitors (SGLT2i) are expanding, a growing number of older adults have become candidates for treatment. We studied the safety profile of SGLT2i among older ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 24, 2023 Category: Cardiology Authors: Adam Goldman, Boris Fishman, Gilad Twig, Emanuel Raschi, Tali Cukierman-Yaffe, Yonatan moshkovits, Alon Pomerantz, Ilan Ben-Zvi, Rachel Dankner and Elad Maor Tags: Research Source Type: research

Diagnosis of coronary artery disease in patients with type 2 diabetes mellitus based on computed tomography and pericoronary adipose tissue radiomics: a retrospective cross-sectional study
Patients with type 2 diabetes mellitus (T2DM) are highly susceptible to cardiovascular disease, and coronary artery disease (CAD) is their leading cause of death. We aimed to assess whether computed tomography... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 23, 2023 Category: Cardiology Authors: Xiaolin Dong, Na Li, Chentao Zhu, Yujia Wang, Ke Shi, Hong Pan, Shuting Wang, Zhenzhou Shi, Yayuan Geng, Wei Wang and Tong Zhang Tags: Research Source Type: research

Accumulated hypertension burden on atrial fibrillation risk in diabetes mellitus: a nationwide population study
Patients with diabetes mellitus have an increased risk of incident atrial fibrillation (AF). The effect of accumulated hypertension burden is a less well-known modifiable risk factor. We explored the relations... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 19, 2023 Category: Cardiology Authors: JungMin Choi, So ‑Ryoung Lee, Eue‑Keun Choi, HuiJin Lee, MinJu Han, Hyo-Jeong Ahn, Soonil Kwon, Seung-Woo Lee, Kyung‑Do Han, Seil Oh and Gregory Y. H. Lip Tags: Research Source Type: research

Cardiovascular complications in a diabetes prediction model using machine learning: a systematic review
Prediction model has been the focus of studies since the last century in the diagnosis and prognosis of various diseases. With the advancement in computational technology, machine learning (ML) has become the ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 19, 2023 Category: Cardiology Authors: Ooi Ting Kee, Harmiza Harun, Norlaila Mustafa, Nor Azian Abdul Murad, Siok Fong Chin, Rosmina Jaafar and Noraidatulakma Abdullah Tags: Review Source Type: research

Association of stress hyperglycemia ratio and poor long-term prognosis in patients with myocardial infarction with non-obstructive coronary arteries
Stress hyperglycemia ratio (SHR) is a novel biomarker of true acute hyperglycemia condition and is associated with a worse prognosis in patients with myocardial infarction (MI). However, the effects of SHR in ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 16, 2023 Category: Cardiology Authors: Fuad A. Abdu, Jassur Galip, Penglong Qi, Wen Zhang, Abdul-Quddus Mohammed, Lu Liu, Guoqing Yin, Ayman A. Mohammed, Redhwan M. Mareai, Rong Jiang, Yawei Xu and Wenliang Che Tags: Research Source Type: research