Association between sodium glucose co-transporter 2 inhibitors and a reduced risk of heart failure in patients with type 2 diabetes mellitus: a real-world nationwide population-based cohort study
Recently, two large randomized controlled trials which only included patients with underlying cardiovascular disease (CVD) or patients at high risk for CVD showed that two sodium glucose co-transporter 2 inhib... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 23, 2018 Category: Cardiology Authors: Young-Gun Kim, Seung Jin Han, Dae Jung Kim, Kwan-Woo Lee and Hae Jin Kim Tags: Original investigation Source Type: research

Non-culprit plaque characteristics in acute coronary syndrome patients with raised hemoglobinA1c: an intravascular optical coherence tomography study
Raised hemoglobinA1c (HbA1c) is an indicator of pre-diabetes, which is associated with increased risk of coronary artery disease. However, the detailed morphological characteristics of non-culprit plaques in a... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 15, 2018 Category: Cardiology Authors: Shaotao Zhang, Jiannan Dai, Haibo Jia, Sining Hu, Hongwei Du, Ning Li, Yongpeng Zou, Yanan Zou, Shenhong Jing, Yan Wang, Rong Sun and Bo Yu Tags: Original investigation Source Type: research

Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats
Calcium/calmodulin-dependent kinase II-delta (CaMKII δ) activity is enhanced during hyperglycemia and has been shown to alter intracellular calcium handling in cardiomyocytes, ultimately leading to reduced card... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 14, 2018 Category: Cardiology Authors: Lorna J. Daniels, Rachel S. Wallace, Olivia M. Nicholson, Genevieve A. Wilson, Fiona J. McDonald, Peter P. Jones, J. Chris Baldi, Regis R. Lamberts and Jeffrey R. Erickson Tags: Original investigation Source Type: research

Rationale and design of study of dapagliflozin versus sitagliptin treatment efficacy on prevention of cardiovascular risk factors in type 2 diabetes patients: the DIVERSITY-CVR study
Recent studies reported that sodium glucose cotransporter 2 (SGLT2) inhibitors reduced the cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) compared to placebo in contras... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 12, 2018 Category: Cardiology Authors: Fumika Shigiyama, Naoki Kumashiro, Ayako Fuchigami and Takahisa Hirose Tags: Study protocol Source Type: research

Clinical application of glucagon-like peptide-1 receptor agonists in cardiovascular disease: lessons from recent clinical cardiovascular outcomes trials
Recent clinical trials investigating cardiovascular (CV) safety of newer antidiabetic agents have been rapidly and largely changing the landscape of diabetes care and providing highly important clinical inform... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 12, 2018 Category: Cardiology Authors: Atsushi Tanaka and Koichi Node Tags: Commentary Source Type: research

Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study
Local, abdominal fat depots may be related to alterations in cardiac function and morphology due to a metabolic linkage. Thus, we aimed to determine their association with subtle cardiac changes and the potent... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 12, 2018 Category: Cardiology Authors: Christopher L. Schlett, Roberto Lorbeer, Carolyn Arndt, Sigrid Auweter, J ürgen Machann, Holger Hetterich, Birgit Linkohr, Wolfgang Rathmann, Annette Peters and Fabian Bamberg Tags: Original investigation Source Type: research

Comparing the inflammatory profiles for incidence of diabetes mellitus and cardiovascular diseases: a prospective study exploring the ‘common soil’ hypothesis
Chronic low-grade inflammation and associated insulin resistance and metabolic abnormalities have been proposed as ‘common soil’ for diabetes mellitus (DM) and cardiovascular disease (CVD). This paper aimed to... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 12, 2018 Category: Cardiology Authors: Xue Bao, Yan Born é, Linda Johnson, Iram Faqir Muhammad, Margaretha Persson, Kaijun Niu and Gunnar Engström Tags: Original investigation Source Type: research

Skin autofluorescence predicts major adverse cardiovascular events in patients with type 1 diabetes: a 7-year follow-up study
Advanced glycation end-products play a role in diabetic vascular complications. Their optical properties allow to estimate their accumulation in tissues by measuring the skin autofluorescence (SAF). We searche... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 8, 2018 Category: Cardiology Authors: C. Blanc-Bisson, F. L. Velayoudom-Cephise, A. Cougnard-Gregoire, C. Helmer, K. Rajaobelina, C. Delcourt, L. Alexandre, L. Blanco, K. Mohammedi, M. Monlun and V. Rigalleau Tags: Original investigation Source Type: research

Influence of micro- and macro-vascular disease and Tumor Necrosis Factor Receptor 1 on the level of lower-extremity amputation in patients with type 2 diabetes
Patients with type 2 diabetes (T2D) face a high amputation rate. We investigated the relationship between the level of amputation and the presence of micro or macro-vascular disease and related circulating bio... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 8, 2018 Category: Cardiology Authors: Fabrice Schneider, Pierre-Jean Saulnier, Elise Gand, Mathieu Desvergnes, Nicolas Lefort, Eric Thorin, Nathalie Thorin-Trescases, Kamel Mohammedi, St éphanie Ragot, Jean-Baptiste Ricco and Samy Hadjadj Tags: Original investigation Source Type: research

Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007 –2017
Cardiovascular disease (CVD) is a common comorbidity in type 2 diabetes (T2DM). CVD ’s prevalence has been growing over time. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 8, 2018 Category: Cardiology Authors: Thomas R. Einarson, Annabel Acs, Craig Ludwig and Ulrik H. Panton Tags: Review Source Type: research

Comparative cardiovascular outcomes in the era of novel anti-diabetic agents: a comprehensive network meta-analysis of 166,371 participants from 170 randomized controlled trials
Cardiovascular (CV) safety of one anti-diabetic medication over another remains partially delineated. We sought to assess the comparative effect on CV outcomes among novel anti-diabetic agents. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 5, 2018 Category: Cardiology Authors: Xiao-dong Zhuang, Xin He, Da-ya Yang, Yue Guo, Jian-gui He, Hai-peng Xiao and Xin-xue Liao Tags: Review Source Type: research

Sex-specific associations between adolescent categories of BMI with cardiovascular and non-cardiovascular mortality in midlife
Most studies linking long-term consequences of adolescent underweight and obesity are limited to men. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 5, 2018 Category: Cardiology Authors: Ariel Furer, Arnon Afek, Omri Orr, Liron Gershovitz, Moran Landau Rabbi, Estela Derazne, Orit Pinhas-Hamiel, Noam Fink, Adi Leiba, Amir Tirosh, Jeremy D. Kark and Gilad Twig Tags: Original investigation Source Type: research

Influence of high density lipoprotein cholesterol levels on circulating monocytic angiogenic cells functions in individuals with type 2 diabetes mellitus
High-density lipoproteins (HDLs) can exert anti-atherogenic effects. On top of removing excess cholesterol through reverse cholesterol transport, HDLs play beneficial actions on endothelial function and integr... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 5, 2018 Category: Cardiology Authors: Daniela Lucchesi, Simona Georgiana Popa, Veronica Sancho, Laura Giusti, Monia Garofolo, Giuseppe Daniele, Laura Pucci, Roberto Miccoli, Giuseppe Penno and Stefano Del Prato Tags: Original investigation Source Type: research

Burden of cardiovascular risk factors and disease among patients with type 1 diabetes: results of the Australian National Diabetes Audit (ANDA)
Cardiovascular risk stratification is complex in type 1 diabetes. We hypothesised that traditional and diabetes-specific cardiovascular risk factors were prevalent and strongly associated with cardiovascular d... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 2, 2018 Category: Cardiology Authors: Anthony Pease, Arul Earnest, Sanjeeva Ranasinha, Natalie Nanayakkara, Danny Liew, Natalie Wischer, Sofianos Andrikopoulos and Sophia Zoungas Tags: Original investigation Source Type: research

Donor artery stenosis interactions with diastolic blood pressure on coronary collateral flow in type 2 diabetic patients with chronic total occlusion
We investigated whether and to what extent stenosis of predominant collateral donor artery (PCDA) affects coronary collateral flow in relation to blood pressure (BP) in type 2 diabetic patients with chronic to... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 1, 2018 Category: Cardiology Authors: Ying Shen, Zhen Kun Yang, Jian Hu, Xiao Qun Wang, Yang Dai, Su Zhang, Rui Yan Zhang, Lin Lu, Feng Hua Ding and Wei Feng Shen Tags: Original investigation Source Type: research

Circulating levels of adipose tissue-derived inflammatory factors in elderly diabetes patients with carotid atherosclerosis: a retrospective study
Inflammation has been recognized as a key feature of both type 2 diabetes mellitus (T2DM) and atherosclerosis. However, the relationships between circulating levels of novel adipose tissue-derived inflammatory... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 30, 2018 Category: Cardiology Authors: Wei Yang, Yun Li, Jie-Yu Wang, Rui Han and Li Wang Tags: Original Investigation Source Type: research

Exploration of the clinical benefits of sodium glucose co-transporter 2 inhibitors in diabetic patients with concomitant heart failure
Prevention and treatment strategies for heart failure (HF) in diabetes have not been fully established, at least partly due to lack of recognition of a pathological link between the two and effective antidiabe... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 25, 2018 Category: Cardiology Authors: Atsushi Tanaka and Koichi Node Tags: Commentary Source Type: research

Effect of canagliflozin on left ventricular diastolic function in patients with type 2 diabetes
Type 2 diabetes mellitus (T2DM) greatly increases the risks of cardiovascular disease and heart failure. In particular, left ventricular diastolic dysfunction that develops from the early stages of T2DM is an ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 22, 2018 Category: Cardiology Authors: Daisuke Matsutani, Masaya Sakamoto, Yosuke Kayama, Norihiko Takeda, Ryuzo Horiuchi and Kazunori Utsunomiya Tags: Original investigation Source Type: research

The effect of DPP-4 inhibition to improve functional outcome after stroke is mediated by the SDF-1 α/CXCR4 pathway
Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) are approved drugs for the treatment of hyperglycemia in patients with type 2 diabetes. These effects are mainly mediated by inhibiting endogenous glucagon-... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 19, 2018 Category: Cardiology Authors: Fausto Chiazza, Harald Tammen, Hiranya Pintana, Grazyna Lietzau, Massimo Collino, Thomas Nystr öm, Thomas Klein, Vladimer Darsalia and Cesare Patrone Tags: Original investigation Source Type: research

Effects of linagliptin on endothelial function and postprandial lipids in coronary artery disease patients with early diabetes: a randomized, placebo-controlled, double-blind trial
Early glucose lowering intervention in subjects with type 2 diabetes mellitus was demonstrated to be beneficial in terms of micro- and macrovascular risk reduction. However, most of currently ongoing cardiovas... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 17, 2018 Category: Cardiology Authors: Norbert J. Tripolt, Felix Aberer, Regina Riedl, Jasmin Url, Gudrun Dimsity, Andreas Meinitzer, Tatjana Stojakovic, Faisal Aziz, Ronald H ödl, Gabriele Brachtl, Dirk Strunk, Marianne Brodmann, Franz Hafner and Harald Sourij Tags: Original investigation Source Type: research

No detectable differential microRNA expression between non-atherosclerotic arteries of type 2 diabetic patients (treated or untreated with metformin) and non-diabetic patients
Type 2 diabetes mellitus (T2DM) is an independent risk factor of cardiovascular disease (CVD), however, the underlying mechanisms are largely unknown. Using non-atherosclerotic internal thoracic arteries (ITAs... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 17, 2018 Category: Cardiology Authors: Lasse Bach Steffensen, S øren Feddersen, Simone Rørdam Preil and Lars Melholt Rasmussen Tags: Original investigation Source Type: research

Prevalence and incidence of complications at diagnosis of T2DM and during follow-up by BMI and ethnicity: a matched case –control analysis
To estimate the risk of developing long-term major cardiovascular and renal complications in relation to levels of body mass index (BMI) in a population of White European (WE), African-Caribbean (AC), and Sout... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 15, 2018 Category: Cardiology Authors: Ebenezer S. Owusu Adjah, Srikanth Bellary, Wasim Hanif, Kiran Patel, Kamlesh Khunti and Sanjoy K. Paul Tags: Original investigation Source Type: research

Childhood retinol-binding protein 4 (RBP4) levels predicting the 10-year risk of insulin resistance and metabolic syndrome: the BCAMS study
Elevated retinol-binding protein 4 (RBP4) levels may contribute to the development of metabolic abnormalities, but prospective studies evaluating the association between childhood RBP4 levels and metabolic syn... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 14, 2018 Category: Cardiology Authors: Ge Li, Issy C. Esangbedo, Lu Xu, Junling Fu, Lujiao Li, Dan Feng, Lanwen Han, Xinhua Xiao, Mingyao Li, Jie Mi, Ming Li, Shan Gao and Steven M. Willi Tags: Original investigation Source Type: research

Adverse effects of Hif1a mutation and maternal diabetes on the offspring heart
Epidemiological studies show that maternal diabetes predisposes offspring to cardiovascular and metabolic disorders. However, the precise mechanisms for the underlying penetrance and disease predisposition rem... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 12, 2018 Category: Cardiology Authors: Radka Cerychova, Romana Bohuslavova, Frantisek Papousek, David Sedmera, Pavel Abaffy, Vladimir Benes, Frantisek Kolar and Gabriela Pavlinkova Tags: Original investigation Source Type: research

Associations of coronary artery calcified plaque density with mortality in type 2 diabetes: the Diabetes Heart Study
Coronary artery calcified plaque (CAC) is strongly predictive of cardiovascular disease (CVD) events and mortality, both in general populations and individuals with type 2 diabetes at high risk for CVD. CAC is... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 11, 2018 Category: Cardiology Authors: Laura M. Raffield, Amanda J. Cox, Michael H. Criqui, Fang-Chi Hsu, James G. Terry, Jianzhao Xu, Barry I. Freedman, J. Jeffrey Carr and Donald W. Bowden Tags: Original investigation Source Type: research

Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes
Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the associat... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 4, 2018 Category: Cardiology Authors: Marc Carbonell, Esmeralda Castelblanco, Xavier Valldeperas, Àngels Betriu, Alícia Traveset, Minerva Granado-Casas, Marta Hernández, Federico Vázquez, Mariona Martín, Esther Rubinat, Albert Lecube, Josep Franch-Nadal, Elvira Fernández, Manel Puig-Dom Tags: Original investigation Source Type: research

The synergistic effects of saxagliptin and metformin on CD34+ endothelial progenitor cells in early type 2 diabetes patients: a randomized clinical trial
Type 2 diabetes is associated with endothelial dysfunction leading to cardiovascular disease. CD34+ endothelial Progenitor Cells (EPCs) are responsible for endothelial repair and neo-angiogenesis and can be us... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 3, 2018 Category: Cardiology Authors: Fiona J. Dore, Cleyton C. Domingues, Neeki Ahmadi, Nabanita Kundu, Yana Kropotova, Sara Houston, Carol Rouphael, Aytan Mammadova, Linda Witkin, Anamil Khiyami, Richard L. Amdur and Sabyasachi Sen Tags: Original investigation Source Type: research

Exercise training and endothelial function in patients with type 2 diabetes: a meta-analysis
Exercise training is considered a cornerstone in the management of type 2 diabetes, which is associated with impaired endothelial function. However, the association of exercise training with endothelial functi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 2, 2018 Category: Cardiology Authors: Shanhu Qiu, Xue Cai, Han Yin, Zilin Sun, Martina Z ügel, Jürgen Michael Steinacker and Uwe Schumann Tags: Original investigation Source Type: research

Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1 year: an open label, non-randomized, controlled study
Cardiovascular disease (CVD) is a leading cause of death among adults with type 2 diabetes mellitus (T2D). We recently reported that glycemic control in patients with T2D can be significantly improved through ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 1, 2018 Category: Cardiology Authors: Nasir H. Bhanpuri, Sarah J. Hallberg, Paul T. Williams, Amy L. McKenzie, Kevin D. Ballard, Wayne W. Campbell, James P. McCarter, Stephen D. Phinney and Jeff S. Volek Tags: Original investigation Source Type: research

Prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in ST-segment elevation myocardial infarction
The aim of the present study was to evaluate the prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in patients with ST-segment elevation myocardial infarction (STEMI). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 30, 2018 Category: Cardiology Authors: Germ án Cediel, Ferran Rueda, Claus Oxvig, Teresa Oliveras, Carlos Labata, Oriol de Diego, Marc Ferrer, M. Cruz Aranda-Nevado, Judith Serra-Gregori, Julio Núñez, Cosme García and Antoni Bayes-Genis Tags: Original investigation Source Type: research

SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice
Type 2 diabetes (T2D) is associated with generalized vascular dysfunction characterized by increases in large artery stiffness, endothelial dysfunction, and vascular smooth muscle dysfunction. Sodium glucose c... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 27, 2018 Category: Cardiology Authors: Dustin M. Lee, Micah L. Battson, Dillon K. Jarrell, Shuofei Hou, Kayl E. Ecton, Tiffany L. Weir and Christopher L. Gentile Tags: Original investigation Source Type: research

Novel risk genes identified in a genome-wide association study for coronary artery disease in patients with type 1 diabetes
Patients with type 1 diabetes are more at risk of coronary artery disease than the general population. Although evidence points to a genetic risk there have been no study investigating genetic risk factors of ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 25, 2018 Category: Cardiology Authors: Romain Charmet, Seamus Duffy, Sareh Keshavarzi, Beata Gyorgy, Michel Marre, Peter Rossing, Amy Jayne McKnight, Alexander P. Maxwell, Tarun veer Singh Ahluwalia, Andrew D. Paterson, David-Alexandre Tr égouët and Samy Hadjadj Tags: Original investigation Source Type: research

The role of dipeptidylpeptidase-4 inhibitors in management of cardiovascular disease in diabetes; focus on linagliptin
Multiple population based analyses have demonstrated a high incidence of cardiovascular disease (CVD) and cardiovascular (CV) mortality in subjects with T2DM that reduces life expectancy by as much as 15 years... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 18, 2018 Category: Cardiology Authors: Annayya R. Aroor, Camila Manrique-Acevedo and Vincent G. DeMarco Tags: Review Source Type: research

Diabetes, cardiovascular disease and the microcirculation
Cardiovascular disease (CVD) is the leading cause of mortality in people with type 2 diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be accounted for by conventional cardiov... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 18, 2018 Category: Cardiology Authors: W. David Strain and P. M. Pald ánius Tags: Review Source Type: research

Prevalence of left ventricular systolic dysfunction and heart failure with reduced ejection fraction in men and women with type 2 diabetes mellitus: a systematic review and meta-analysis
Type 2 diabetes mellitus (T2D) is associated with the development of left ventricular systolic dysfunction (LVSD) and heart failure with reduced ejection fraction (HFrEF). T2D patients with LVSD are at higher ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 18, 2018 Category: Cardiology Authors: Selma Bouthoorn, Aisha Gohar, Gideon Valstar, Hester M. den Ruijter, J. B. Reitsma, Arno W. Hoes and Frans H. Rutten Tags: Original investigation Source Type: research

Sarcopenic obesity assessed using dual energy X-ray absorptiometry (DXA) can predict cardiovascular disease in patients with type 2 diabetes: a retrospective observational study
Sarcopenic obesity, defined as reduced skeletal muscle mass and power with increased adiposity, was reported to be associated with cardiovascular disease risks in previous cross-sectional studies. Whole body d... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 10, 2018 Category: Cardiology Authors: Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Kazutaka Tsujimoto, Isao Minami, Takanobu Yoshimoto and Yoshihiro Ogawa Tags: Original investigation Source Type: research

Antidiabetic treatment patterns and specialty care utilization among patients with type 2 diabetes and cardiovascular disease
To evaluate real-world patient characteristics, medication use, and health care utilization patterns in patients with type 2 diabetes with established cardiovascular disease (CVD). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 10, 2018 Category: Cardiology Authors: Kevin M. Pantalone, Anita D. Misra-Hebert, Todd M. Hobbs, Xinge Ji, Sheldon X. Kong, Alex Milinovich, Wayne Weng, Janine Bauman, Rahul Ganguly, Bartolome Burguera, Michael W. Kattan and Robert S. Zimmerman Tags: Original investigation Source Type: research

Liraglutide suppresses non-esterified free fatty acids and soluble vascular cell adhesion molecule-1 compared with metformin in patients with recent-onset type 2 diabetes
It has been suggested that liraglutide could have an impact on glucose and lipid metabolism disorder and adhesion molecule activation, which may play important roles in the vascular damage of diabetes. In this... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 10, 2018 Category: Cardiology Authors: Xiao-min Chen, Wen-qiang Zhang, Yuan Tian, Li-fen Wang, Chan-chan Chen and Chuan-mei Qiu Tags: Original investigation Source Type: research

Empagliflozin influences blood viscosity and wall shear stress in subjects with type 2 diabetes mellitus compared with incretin-based therapy
Cardiovascular protection following empagliflozin therapy is not entirely attributable to the glucose lowering effect. Increased hematocrit might influence the shear stress that is the main force acting on the... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 9, 2018 Category: Cardiology Authors: Concetta Irace, Francesco Casciaro, Faustina Barbara Scavelli, Rosa Oliverio, Antonio Cutruzzol à, Claudio Cortese and Agostino Gnasso Tags: Original investigation Source Type: research

The effect of change in fasting glucose on the risk of myocardial infarction, stroke, and all-cause mortality: a nationwide cohort study
The effect of change in blood glucose levels on the risk of cardiovascular disease among individuals without diabetes is currently unclear. We aimed to examine the association of change in fasting serum glucos... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 7, 2018 Category: Cardiology Authors: Gyeongsil Lee, Sung Min Kim, Seulggie Choi, Kyuwoong Kim, Su-Min Jeong, Joung Sik Son, Jae-Moon Yun and Sang Min Park Tags: Original investigation Source Type: research

Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria
The urinary proteomic classifier CKD273 has shown promise for prediction of progressive diabetic nephropathy (DN). Whether it is also a determinant of mortality and cardiovascular disease in patients with micr... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 6, 2018 Category: Cardiology Authors: Gemma E. Currie, Bernt Johan von Scholten, Sheon Mary, Jose-Luis Flores Guerrero, Morten Lindhardt, Henrik Reinhard, Peter K. Jacobsen, William Mullen, Hans-Henrik Parving, Harald Mischak, Peter Rossing and Christian Delles Tags: Original investigation Source Type: research

Correction to: Type 2 diabetes-associated carotid plaque burden is increased in patients with retinopathy compared to those without retinopathy
The author found errors in Table 1 after publication of the original article [1]. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 5, 2018 Category: Cardiology Authors: N úria Alonso, Alicia Traveset, Esther Rubinat, Emilio Ortega, Nuria Alcubierre, Jordi Sanahuja, Marta Hernández, Angels Betriu, Carmen Jurjo, Elvira Fernández and Didac Mauricio Tags: Correction Source Type: research

Liraglutide downregulates hepatic LDL receptor and PCSK9 expression in HepG2 cells and db/db mice through a HNF-1a dependent mechanism
Proprotein convertase subtilisin/kexin type 9 (PCSK9), a major regulator of cholesterol homeostasis, is associated with glucose metabolism. Liraglutide, a glucagon-like peptide-1 receptor agonist, can increase... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 4, 2018 Category: Cardiology Authors: Sheng-Hua Yang, Rui-Xia Xu, Chuan-Jue Cui, Yin Wang, Ying Du, Zhi-Guo Chen, Yu-Hong Yao, Chun-Yan Ma, Cheng-Gang Zhu, Yuan-Lin Guo, Na-Qiong Wu, Jing Sun, Bu-Xing Chen and Jian-Jun Li Tags: Original investigation Source Type: research

The role of obesity in carotid plaque instability: interaction with age, gender, and cardiovascular risk factors
In the last decade, several studies have reported an unexpected and seemingly paradoxical inverse correlation between BMI and incidence of cardiovascular diseases. This so called “obesity paradox effect” has b... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 29, 2018 Category: Cardiology Authors: Valentina Rovella, Lucia Anemona, Marina Cardellini, Manuel Scimeca, Andrea Saggini, Giuseppe Santeusanio, Elena Bonanno, Manuela Montanaro, Iacopo Maria Legramante, Arnaldo Ippoliti, Nicola Di Daniele, Massimo Federici and Alessandro Mauriello Tags: Original investigation Source Type: research

HbA1c variability and diabetic peripheral neuropathy in type 2 diabetic patients
Diabetic complications may be associated with impaired time-dependent glycemic control. Therefore, long-term glycemic variability, assessed by variations in haemoglobin A1c (HbA1c), may be a potential risk fac... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 29, 2018 Category: Cardiology Authors: Jian-bin Su, Li-hua Zhao, Xiu-lin Zhang, Hong-li Cai, Hai-yan Huang, Feng Xu, Tong Chen and Xue-qin Wang Tags: Original investigation Source Type: research

Bone markers and cardiovascular risk in type 2 diabetes patients
Vascular calcifications are associated with a three- to fourfold increased risk of cardiovascular disease (CVD) and are highly prevalent in type 2 diabetes patients. Emerging evidence indicates that vascular c... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 23, 2018 Category: Cardiology Authors: Sabine R. Zwakenberg, Yvonne T. van der Schouw, Casper G. Schalkwijk, Annemieke M. W. Spijkerman and Joline W. J. Beulens Tags: Original investigation Source Type: research

Exercise capacity in diabetes mellitus is predicted by activity status and cardiac size rather than cardiac function: a case control study
The reasons for reduced exercise capacity in diabetes mellitus (DM) remains incompletely understood, although diastolic dysfunction and diabetic cardiomyopathy are often favored explanations. However, there is... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 23, 2018 Category: Cardiology Authors: Timothy J. Roberts, Andrew T. Burns, Richard J. MacIsaac, Andrew I. MacIsaac, David L. Prior and Andr é La Gerche Tags: Original investigation Source Type: research

Correction to: HbA1c versus oral glucose tolerance test as a method to diagnose diabetes mellitus in vascular surgery patients
The authors found errors in Table 1 after publication of the original article [1]. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 22, 2018 Category: Cardiology Authors: Iren D. Hjellestad, Marianne C. Astor, Roy M. Nilsen, Eirik S øfteland and Torbjørn Jonung Tags: Correction Source Type: research

Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides
Diabetic cardiomyopathy (DCM) is a chronic complication in individuals with diabetes and is characterized by ventricular dilation and hypertrophy, diastolic dysfunction, decreased or preserved systolic functio... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 22, 2018 Category: Cardiology Authors: Nilanjan Ghosh and Rajesh Katare Tags: Review Source Type: research

Association between triglyceride glucose index and arterial stiffness in Korean adults
The triglyceride glucose (TyG) index has been suggested as a simple surrogate marker of insulin resistance. However, there are limited data regarding the association between the TyG index and arterial stiffnes... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 21, 2018 Category: Cardiology Authors: Sang Bae Lee, Chul Woo Ahn, Byoung Kwon Lee, Shinae Kang, Ji Sun Nam, Ji Hong You, Min Jin Kim, Min Kyung Kim and Jong Suk Park Tags: Original investigation Source Type: research