Abstract PR12: Transcriptional regulation of metabolism by MLX and its binding partners is essential for tumor cell survival and spermatogenesis
Conclusions: Transcriptional coordination between the mitogen- and nutrient-responsive arms of the MAX/MLX network exhibits context-dependent lethality. MondoA and Chrebp exhibit non-redundant functions in both cancer cells and normal mouse tissue, and inactivation of Mlx phenocopies loss of both factors, suggesting that targeting Mlx can inhibit both MondoA and Chrebp transcriptional activity and subsequent metabolic output. Metabolic regulation by Mlx impacts normal testicular tissue homeostasis and differentiation in the mouse, and its deregulation is associated with human diseases such as loss of function associated wi...
Source: Molecular Cancer Research - January 15, 2016 Category: Cancer & Oncology Authors: Carroll, P. A., Diolaiti, D., Cheng, P.-F., Gu, H., Djukovic, D., Raftery, D., Ayer, D. E., Muller, C. H., Eisenman, R. N. Tags: Cancer Metabolic Pathways: Oral Presentations - Proffered Abstracts Source Type: research
Expression of P450 Aromatase in Granulosa Cell Tumors and Sertoli-Stromal Cell Tumors of the Ovary: Which Cells Are Responsible for Estrogenesis?
In conclusion, the expression of P450 aromatase corresponds to specific cell morphology in sex cord-stromal tumors, including recurrent tumors. Aromatase status in granulosa cell tumors provides helpful information on whether serum estradiol could be a marker for recurrence. (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - December 8, 2015 Category: Pathology Tags: Pathology of the Upper Genital Tract: Original Articles Source Type: research
Suppression of Sertoli cell tumour development during the first wave of spermatogenesis in inhibin ?-deficient mice.
In conclusion, acute FSH suppression during the 1st or 2nd week after birth in Inha-KO mice profoundly suppresses Sertoli cell tumour progression, probably by inhibiting proliferation in the adult, with early postnatal Sertoli cells being most sensitive to FSH action.
PMID: 26488911 [PubMed - as supplied by publisher] (Source: Reproduction, Fertility, and Development)
Source: Reproduction, Fertility, and Development - October 22, 2015 Category: Reproduction Medicine Authors: Haverfield JT, Stanton PG, Loveland KL, Zahid H, Nicholls PK, Olcorn JS, Makanji Y, Itman CM, Simpson ER, Meachem SJ Tags: Reprod Fertil Dev Source Type: research
Nuclear Localization of β-Catenin in Sertoli Cell Tumors and Other Sex Cord–Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases
In conclusion, SCT-NOS and SSCT frequently show β-catenin nuclear localization. Positive nuclear staining of β-catenin is specific for SCT-NOS, SSCT, and Sertoli–stromal cell tumor among testicular sex cord–stromal tumors but has limited sensitivity (63%) in this group. The similar reactivity of SCT-NOS and SSCT provides additional support that these 2 variants are not distinct entities. (Source: The American Journal of Surgical Pathology)
Source: The American Journal of Surgical Pathology - September 16, 2015 Category: Pathology Tags: Original Articles Source Type: research
Anti-Müllerian hormone: a potentially useful biomarker for the diagnosis of canine Sertoli cell tumours.
CONCLUSION: AMH was shown to be a promising biomarker for the diagnosis of Sertoli cell tumours in dogs.
PMID: 26209243 [PubMed - in process] (Source: Cell Research)
Source: Cell Research - July 28, 2015 Category: Cytology Authors: Holst BS, Dreimanis U Tags: BMC Vet Res Source Type: research
Anti-Müllerian hormone: a potentially useful biomarker for the diagnosis of canine Sertoli cell tumours
Conclusion:
AMH was shown to be a promising biomarker for the diagnosis of Sertoli cell tumours in dogs. (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - July 25, 2015 Category: Veterinary Research Authors: Bodil HolstUlrika Dreimanis Source Type: research
Ovarian hilar proliferations resembling sertoli cell tumours: microscopic neoplasms or non‐neoplastic remnants?
ConclusionsWe feel these uncommon proliferations are likely to represent non‐neoplastic embryological remnants rather than hilar Sertoli cell tumours.This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - July 25, 2015 Category: Pathology Authors: Jennifer Taylor, Blaise A Clarke, Noori U Hasan, Gorana Gasljevic, Matthew Cesari, W Glenn McCluggage Tags: Original Article Source Type: research
Efficacy of ultrasound-guided testicle-sparing surgery for small testicular masses
Conclusion
The OS, the low rate of local recurrence, and absence of complications, tend to demonstrate the safety of the procedure. The benefits to testicular-sparing surgery include improving the patient’s overall quality of life, fertility, endocrine function and negative cosmetic effects of radical orchiectomy. (Source: Journal of Ultrasound)
Source: Journal of Ultrasound - June 23, 2015 Category: Radiology Source Type: research
Inhibin-α, E-cadherin, calretinin and Ki-67 antigen in the immunohistochemical evaluation of canine and human testicular neoplasms.
CONCLUSIONS: The applied anti-human monoclonal antibodies against common antigens and markers of human testicular neoplasms could be routinely used for the immunohistochemical evaluation of canine testicular tumors.
PMID: 25511291 [PubMed - in process] (Source: Folia Histochemica et Cytobiologica)
Source: Folia Histochemica et Cytobiologica - June 3, 2015 Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research
A novel inherited mutation in PRKAR1A abrogates preRNA splicing in a Carney complex family
Conclusion This study reports a novel splicing mutation in the PRKAR1A gene that adds to the genetic heterogeneity of CNC. Teaser The aim of this study was to identify genetic abnormalities in a Chinese Carney complex family. Using whole-exome sequencing, we discovered a heterozygous mutation at the splicing acceptor site of PRKAR1A exon 6. This splicing mutation causes early termination of transcription, resulting in PRKAR1A haploinsufficiency in the subjects with Carney complex in the family. (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - June 1, 2015 Category: Cardiology Source Type: research
Ovarian Sertoli-Leydig Cell Tumor with Predominant Heterologous Mucinous Differentiation and Foci of Hepatocytic Differentiation: Case Report and Review of The Literature.
We present a case of a 15-year old girl diagnosed with Sertoli-Leydig cell tumor with heterologous elements consisting predominantly of mucinous epithelium and a sparse Sertoli-Leydig cell component, mimicking mucinous neoplasm. Furthermore, foci of hepatocytic differentiation were also identified. Immunohistochemical stains showed the component of Sertoli cell differentiation was positive for cytokeratin 18 and inhibin. The component of Leydig cell differentiation was strongly positive for inhibin. The component of hepatocytic differentiation was positive for low molecular weight keratin, HepPar1, alpha-fetoprotein and we...
Source: Annals of Clinical and Laboratory Science - May 1, 2015 Category: Laboratory Medicine Authors: Liang L, Menzin A, Lovecchio JL, Navarro MD Tags: Ann Clin Lab Sci Source Type: research
A case of familial carney complex.
Abstract
Carney complex is a syndrome characterized by skin pigmentation abnormalities, myxomas, endocrine tumors/overactivity, and schwannomas. It is caused by a mutation in the PRKAR1A gene that encodes the enzyme protein kinase A regulatory subunit type 1 alpha. A 23-year old male was diagnosed with Carney complex on the basis of spotty skin lentigines on his face and lips, multiple thyroid neoplasms, a right ventricular myxoma, and bilateral testicular tumors. A total bilateral orchectomy was performed and the pathological findings revealed Leydig's cell tumors on one side and a Sertoli cell tumor on t...
Source: Archives of Iranian Medicine - May 1, 2015 Category: Middle East Health Authors: Zhang YL, Wang XC, Yu W, Pei LP, Ma Y, Jiang S, Sun YP Tags: Arch Iran Med Source Type: research
46,XY Gonadal Dysgenesis due to a Homozygous Mutation in Desert Hedgehog (DHH) Identified by Exome-Sequencing.
CONCLUSION: Mutations in DHH play a role in 46,XY gonadal dysgenesis and are associated with seminoma formation and a neuropathy with minifascicle formation. Gonadal dysgenesis in these cases may be due to impairment of Sertoli cell - Leydig cell interaction during gonadal development.
PMID: 25927242 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2015 Category: Endocrinology Authors: Werner R, Merz H, Birnbaum W, Marshall L, Schröder T, Reiz B, Kavran JM, Bäumer T, Capetian P, Hiort O Tags: J Clin Endocrinol Metab Source Type: research
Ovarian Sex Cord-Stromal Tumors in Patients With Probable or Confirmed Germline DICER1 Mutations
We describe the morphologic and immunophenotypic findings of 4 sex cord-stromal tumors arising in patients with proven or likely germline DICER1 mutations including 3 individuals from 1 family. Three tumors showed similar appearances characterized by marked architectural and cytologic heterogeneity including sertoliform, juvenile granulosa cell tumor-like, and unclassifiable elements. The remaining case mainly showed heterologous mucinous epithelial and neuroendocrine differentiation with only a minor intermediate-grade Sertoli cell component. This tumor and one of the 3 former cases arose in related patients with identica...
Source: International Journal of Gynecological Pathology - April 8, 2015 Category: Pathology Tags: Pathology of the Upper Genital Tract: Original Articles Source Type: research
[Malignant Sertoli cell tumors of the testes].
We present a patient with a lymphogenic metastasized Sertoli cell tumor, who 24 months after orchiectomy and extended retroperitoneal lymphadenectomy is relapse-free.
PMID: 25821170 [PubMed - as supplied by publisher] (Source: Der Urologe. Ausg. A)
Source: Der Urologe. Ausg. A - March 28, 2015 Category: Urology & Nephrology Authors: Günzel K, Wegner H, Cash H, Lohneis P, Kempkensteffen C, Miller K, Hinz S Tags: Urologe A Source Type: research
