Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features
Testicular tumors are incredibly diverse and one of the most challenging areas in surgical pathology. Because of the rarity and overlapping features with numerous entities occurring in the testis and paratestis, these tumors pose a diagnostic challenge even to the most experienced general pathologists. In 2016, the latest “World Health Organization (WHO) classification of testicular tumors” was released, which incorporated several updates to the previous 2004 classification system. These updates involved several entities, including germ cell tumors, sex cord-stromal tumors, tumors containing both germ cells and sex-cor...
Source: Advances in Anatomic Pathology - June 24, 2021 Category: Pathology Tags: Review Articles Source Type: research
Polypyrimidine tract-binding protein 1 regulates the Sertoli cell blood-testis barrier by promoting the expression of tight junction proteins
Exp Ther Med. 2021 Aug;22(2):847. doi: 10.3892/etm.2021.10279. Epub 2021 Jun 7.ABSTRACTSertoli cells (SCs) are an important component of spermatogenic tubules. The blood-testis barrier (BTB) is composed of SCs and is necessary for the development and maturity of spermatogenic cells. When the tight connection between SCs is destroyed, the BTB loses its integrity, leading to impaired spermatogenesis. Polypyrimidine tract-binding protein 1 (PTBP1) is a key protein involved in precursor mRNA splicing and selective splicing events, which directly affects tumor cell proliferation and influences the formation of the blood-tumor b...
Source: Experimental and Therapeutic Medicine - June 21, 2021 Category: General Medicine Authors: Zhe Yang Zhi Liu Yanping Yang Yanping Dai Xiaoqin Gao Source Type: research
IJERPH, Vol. 18, Pages 5648: Malignant Germ Cell Tumors and Their Precursor Gonadal Lesions in Patients with XY-DSD: A Case Series and Review of the Literature
ina Rall
The risk of gonadal germ cell tumors is increased over the lifetime of patients with XY-disorders of sex development (XY-DSD). The aim of this study was to evaluate clinical features and histopathological outcome after gonadectomy in patients with XY-DSD to assess the risk of malignant transformation to gonadal germ cell tumors. Thirty-five women treated for XY-DSD at our hospital between 2003 and 2020 were enrolled in this study. Twenty-seven (77%) underwent prophylactic gonadectomy, 10 (29%) at our department and 17 (48%) at external hospitals. Eight (23%) patients didn’t receive gonadectomy. Of the patien...
Source: International Journal of Environmental Research and Public Health - May 25, 2021 Category: Environmental Health Authors: Sahra Steinmacher Sara Y. Brucker Andrina K ölle Bernhard Kr ämer Dorit Sch öller Katharina Rall Tags: Article Source Type: research
Bowel incarceration within the vaginal tunic in a three-and-half-year-old bilaterally cryptorchid Lhasa Apso
Cryptorchidism in dogs is of clinical concern due to its association with development of Sertoli cell tumours, seminomas and spermatic cord torsion. A patent inguinal ring has been found as a risk factor for p... (Source: Acta Veterinaria Scandinavica)
Source: Acta Veterinaria Scandinavica - May 19, 2021 Category: Veterinary Research Authors: Dorcas Oyueley Kodie, Noah Segun Oyetayo, Oladotun Solomon Awoyemi, Cecelia Omowunmi Oguntoye and Oghenemega David Eyarefe Tags: Case report Source Type: research
A case of abdominal migration of the testes presenting with azoospermia
Nagoya J Med Sci. 2021 Feb;83(1):195-199. doi: 10.18999/nagjms.83.1.195.ABSTRACT31-year-old male was referred to our hospital due to azoospermia. Physical examination revealed impalpable testes in the scrotum, and operative scar presented at lower abdominal midline. Magnetic resonance imaging (MRI) revealed that small testes were located subcutaneously in the lower abdominal midline. Since luteinizing hormone (LH) and follicle stimulating hormone (FSH) were elevated, we diagnosed non-obstructive azoospermia (NOA) due to abdominal migration of the testes. Microscopic testicular sperm extraction (micro-TESE) was performed, h...
Source: Nagoya Journal of Medical Science - March 17, 2021 Category: International Medicine & Public Health Authors: Hatsuki Hibi Miho Sugie Tadashi Ohori Yoshimasa Asada Source Type: research
