Immunohistochemical Detection of Pax8 and Napsin A in Canine Thyroid Tumours: Comparison with Thyroglobulin, Calcitonin and Thyroid Transcription Factor 1
Publication date: Available online 24 August 2016 Source:Journal of Comparative Pathology Author(s): J.A. Ramos-Vara, C.B. Frank, D. DuSold, M.A. Miller Expression of thyroid transcription factor (TTF)-1 corroborates a thyroid origin of neoplasms. Thyroglobulin and calcitonin immunohistochemistry (IHC) can distinguish between a follicular and C-cell origin of thyroid tumours, respectively. Pax8 (expressed by normal canine thyroid follicular cells) and napsin A (expressed mainly by C-cells) labelling was compared with labelling for TTF-1, thyroglobulin and calcitonin in 114 canine proliferative thyroid lesions. All 81...
Source: Journal of Comparative Pathology - August 24, 2016 Category: Pathology Source Type: research
Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report
10.1080/17843286.2016.1215869 Hale Tuhan (Source: Acta Clinica Belgica)
Source: Acta Clinica Belgica - August 3, 2016 Category: Journals (General) Authors: Hale Tuhan Ayhan Abaci Banu Sars ık T ülay Öztürk Mustafa Olguner Gonul Catli Ahmet Anik Nur Olgun Ece Bober Source Type: research
Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report
. (Source: Acta Clinica Belgica)
Source: Acta Clinica Belgica - August 3, 2016 Category: Journals (General) Authors: Hale Tuhan Ayhan Abaci Banu Sars ık T ülay Öztürk Mustafa Olguner Gonul Catli Ahmet Anik Nur Olgun Ece Bober Source Type: research
Spermatogonial Nature of the Germ Cell Component of Canine Testicular Mixed Germ Cell –Sex Cord Stromal Tumours
Publication date: July 2016 Source:Journal of Comparative Pathology, Volume 155, Issue 1 Author(s): S. Mizukami, T. Murakami, T. Tanaka, N. Machida, K. Nomura, T. Yoshida, M. Shibutani The present study has characterized the germ cell component of canine testicular mixed germ cell–sex cord stromal tumours (MGSCTs) by examining the histological nature and histochemical and immunohistochemical features using gonocytic and spermatogonial cellular markers, c-Kit, placental alkaline phosphatase (PLAP), protein gene product 9.5 (PGP9.5), Sal-like protein 4 (SALL4), and the periodic acid–Schiff (PAS) reactio...
Source: Journal of Comparative Pathology - July 20, 2016 Category: Pathology Source Type: research
Establishment and applications of male germ cell and Sertoli cell lines
Within the seminiferous tubules there are two major cell types, namely male germ cells and Sertoli cells. Recent studies have demonstrated that male germ cells and Sertoli cells can have significant applications in treating male infertility and other diseases. However, primary male germ cells are hard to proliferate in vitro and the number of spermatogonial stem cells is scarce. Therefore, methods that promote the expansion of these cell populations are essential for their use from the bench to the bed side. Notably, a number of cell lines for rodent spermatogonia, spermatocytes and Sertoli cells have been developed, and s...
Source: Reproduction - July 5, 2016 Category: Reproduction Medicine Authors: Wang, H., Wen, L., Yuan, Q., Sun, M., Niu, M., He, Z. Tags: Reviews Source Type: research
Sertoli cell tumor arising in a cryptorchid testis presenting as a content of inguinal hernial sac.
Abstract
Sertoli cell tumors (SCTs) are rare tumors accounting for <1% of all testicular tumors. Here, we report a rare case of SCT in a 60-year-old man presenting as a painless swelling in the right groin since childhood. Clinically, he presented with right-sided inguinal hernia with absence of the right testis. He had normal left testis and had no gynecomastia or infertility. The specimen of hernial sac showed testis with a 1.6 cm × 1.5 cm nodular mass having gray tan-cut surface. Histopathologically, the testis showed atrophy and the nodular portion showed tumor cells arranged in tubular and microcy...
Source: Indian Journal of Pathology and Microbiology - June 30, 2016 Category: Pathology Authors: Venkatesh K, Hemalata M, Sathyavathi S, Kumar S Tags: Indian J Pathol Microbiol Source Type: research
A case of Carney complex presenting as acute testicular pain
We describe the case of a 7-year-old boy who presented with testicular pain but was found to have bilateral testicular lesions later confirmed as Sertoli cell tumors. Genetic testing confirmed a PRKAR1A gene mutation consistent with Carney complex, a rare genetic disorder characterized by skin lesions, myxomas, and multiple endocrine neoplasms. A review of the condition is made highlighting the association with testicular tumors, particularly of Sertoli cell origin. (Source: Urology Annals)
Source: Urology Annals - June 28, 2016 Category: Urology & Nephrology Authors: Adam AlleemudderRajiv Pillai Source Type: research
Spermatogonial Nature of the Germ Cell Component of Canine Testicular Mixed Germ Cell–Sex Cord Stromal Tumours
Publication date: Available online 27 May 2016 Source:Journal of Comparative Pathology Author(s): S. Mizukami, T. Murakami, T. Tanaka, N. Machida, K. Nomura, T. Yoshida, M. Shibutani The present study has characterized the germ cell component of canine testicular mixed germ cell–sex cord stromal tumours (MGSCTs) by examining the histological nature and histochemical and immunohistochemical features using gonocytic and spermatogonial cellular markers, c-Kit, placental alkaline phosphatase (PLAP), protein gene product 9.5 (PGP9.5), Sal-like protein 4 (SALL4), and the periodic acid–Schiff (PAS) reaction....
Source: Journal of Comparative Pathology - May 26, 2016 Category: Pathology Source Type: research
Activins in reproductive biology and beyond
CONCLUSIONS
The field of activin biology has advanced considerably since its initial discovery as an FSH stimulating agent. Now, activin is well known as a growth factor and cytokine that regulates many aspects of reproductive biology, developmental biology and also inflammation and immunological mechanisms. Current research provides evidence for novel roles of activins in maintaining the structure and function of reproductive and other organ systems. The fact that activin A is elevated both locally as well as systemically in major disorders of the reproductive system makes it an important biomarker. Given the established ...
Source: Human Reproduction Update - May 2, 2016 Category: OBGYN Authors: Wijayarathna, R., de Kretser, D. M. Tags: Review Source Type: research
Unusual Sertoli Cell Tumor Associated With Sex Cord Tumor With Annular Tubules in Peutz-Jeghers Syndrome: Report of a Case and Review of the Literature on Ovarian Tumors in Peutz-Jeghers Syndrome
We report the case of an 11-year-old girl with Peutz-Jeghers syndrome and a unilateral ovarian tumor most consistent with Sertoli cell tumor associated with sex cord tumor with annular tubules. The ovary was replaced by a lobular, solid, yellow tumor. Microscopic examination showed 2 components that focally merged. The first was composed of uniform, cytologically bland cells arranged mostly in diffuse sheets and focally in tubules. The second showed typical sex cord tumor with annular tubules with extensive calcification. The predominant component of the tumor clearly fell in the sex cord category and most closely resemble...
Source: International Journal of Surgical Pathology - April 24, 2016 Category: Pathology Authors: Ravishankar, S., Mangray, S., Kurkchubasche, A., Yakirevich, E., Young, R. H. Tags: Case Reports Source Type: research
Testis ultrasound in Klinefelter syndrome infertile men: making the diagnosis and avoiding inappropriate management
Conclusions
Small testes, with a coarse or nodular echotexture, hypervascularization, and microlithiasis are associated with KS. The KS nodules were benign Leydig cell tumors/hyperplasias. (Source: Abdominal Imaging)
Source: Abdominal Imaging - March 29, 2016 Category: Radiology Source Type: research
A spontaneously occurring malignant ovarian Sertoli cell tumor in a young Sprague Dawley rat.
Authors: Kinoshita Y, Yoshizawa K, Emoto Y, Yuki M, Yuri T, Shikata N, Elmore SA, Tsubura A
Abstract
Primary ovarian tumors are generally uncommon in rats used in toxicologic studies. A malignant Sertoli cell tumor was present in the ovary of a 19-week-old female Sprague Dawley rat. Macroscopically, the mass was white and firm, 10 × 13 × 17 mm in size, and located in the right ovary. Histopathologically, the mass was composed of nests of pleomorphic cells, which formed seminiferous-like tubules separated by a thin fibrovascular stroma. The tubules were lined by tumor cells, which had basally located nucl...
Source: Journal of Toxicologic Pathology - March 19, 2016 Category: Toxicology Tags: J Toxicol Pathol Source Type: research
Management of an invasive and metastatic Sertoli cell tumor with associated myelotoxicosis in a dog.
We describe the surgical and post-operative management of a large, invasive, and metastatic functional Sertoli cell tumor in a 9-year-old cryptorchid male Labrador retriever dog. Despite residual disease after surgery, bone marrow recovery occurred without administration of bone marrow stimulants and serum estradiol accurately predicted tumor recurrence.
PMID: 26933269 [PubMed - in process] (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - March 1, 2016 Category: Veterinary Research Authors: Withers SS, Lawson CM, Burton AG, Rebhun RB, Steffey MA Tags: Can Vet J Source Type: research
Value of PAX-8 and SF-1 Immunohistochemistry in the Distinction Between Female Adnexal Tumor of Probable Wolffian Origin and its Mimics
Female adnexal tumors of probable wolffian origin (FATWOs) are rare. They can closely mimic endometrioid adenocarcinomas with a prominent spindle cell component and Sertoli cell tumors (SCTs). To further define their immunohistochemical profile and origin, we investigated the expression of PAX-8, PAX-2, and GATA binding protein 3 (GATA-3) (wolffian markers) and of steroidogenic factor-1 (SF-1) (sex-cord stromal marker) in FATWOs. We also studied the expression of PAX-8 and PAX-2 in endometrioid adenocarcinomas; of SF-1 in Sertoli-Leydig cell and SCTs; and of PAX-8, PAX-2, GATA-3, and SF-1 in rete ovarii—a proposed site o...
Source: International Journal of Gynecological Pathology - February 11, 2016 Category: Pathology Tags: Pathology of the Upper Genital Tract: Original Articles Source Type: research
