International Journal of Surgical Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

De Novo CD5-Positive Diffuse Large B-Cell Lymphoma: Report of a Case Presenting With Cutaneous Involvement and Featuring Extensive Intravascular Dissemination on Postmortem Examination
We report a case of an 84-year old man who presented with cutaneous lesions, malaise, and B-symptoms. A skin biopsy revealed neoplastic cells within the lumen of dermal vessels. The patient deteriorated rapidly and died. On postmortem examination, lymphadenopathy with diffuse effacement of lymph node architecture, widespread intravascular neoplastic cells in the skin, lungs, gastrointestinal tract, adrenal glands, testes, and kidneys; and rare, isolated neoplastic cells within vessels of liver and central nervous system were noted. Intravascular or intrasinusoidal invasion has been previously reported in earlier series of ...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Ubeda Romero, A., Santonja, C., Blanco Garcia, A., Requena, L., Rodriguez Pinilla, S. M. Tags: Case Reports Source Type: research

Primary Extramedullary Plasmacytoma in the Gastroduodenal Canal Associated With Epstein-Barr Virus-Associated Adenocarcinoma of the Stomach: A Case Report
We report herein a case of gastroduodenal extramedullary plasmacytoma simultaneously complicated by multiple gastric Epstein-Barr virus (EBV)–associated adenocarcinomas. The patient underwent distal gastrectomy to treat an adenocarcinoma occupying the gastric antrum. Histopathological examination revealed a massive submucosal plasma cell proliferation adjacent to the adenocarcinoma involving the pylorus to the duodenal bulb. Lambda immunoglobulin light chain restriction indicated that these plasma cells were monoclonal. Because the clinical investigation revealed no other lymphoid neoplasms, primary extramedullary pl...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Takahashi, T., Morita, T., Matsuno, Y. Tags: Case Reports Source Type: research

Primary Sellar Rhabdomyosarcoma Arising in Association With a Pituitary Adenoma
We describe a case of a 56-year-old woman who presented with right eye ptosis and a pituitary mass, which was resected and diagnosed as atypical pituitary adenoma. Because of residual disease and atypical pathology, the patient received adjuvant radiation. Tumor recurrence was noted after 5 months, and a second resection was performed. Nests of atypical pituitary adenoma cells within an exuberant spindle cell stroma were noted, with areas of presumed radiation necrosis. A second recurrence prompted a third resection. After expert consultation and additional immunohistochemical stains for muscle markers, a diagnosis was ren...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Duncan, V. E., Nabors, L. B., Warren, P. P., Conry, R. M., Willey, C. D., Perry, A., Riley, K. O., Hackney, J. R. Tags: Case Reports Source Type: research

Intraosseous Hibernoma in the Sacrum of an Adult
This report describes the histological features of a discrete lesion in the sacrum of an 84-year-old lady. Biopsy of this lesion demonstrated that it consisted predominantly of multivacuolated lipocytes with a morphological and immunohistochemical profile consistent with brown fat cells. The lesion was diagnosed as an intraosseous hibernoma. This is the 16th report in the English literature of a hibernoma occurring outside of a soft tissue location. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Westacott, L., Collins, A., Dickenson, I. Tags: Case Reports Source Type: research

A Case Report of Bilateral Sarcomatoid Carcinoma of Adrenal Glands With Adrenal Insufficiency
Adrenocortical carcinomas are relatively rare, but they are considered to be highly aggressive malignant tumors. Sarcomatoid carcinomas represent an even more aggressive type. Bilateral malignant adrenal tumors are extraordinary rare, except for those that represent metastatic spread from a primary neoplasm. Here we report a case of a 69-year-old woman who presented symptoms that raised strong suspicions of adrenal insufficiency. Bilateral adrenal masses, identified in the imaging study, were responsible for the clinical manifestation and surgically resected. Surgical specimens of the bilateral adrenal tumors shared histol...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Ishikawa, N., Nagase, M., Takami, S., Araki, A., Ishikawa, N., Koike, C., Shiina, H., Maruyama, R. Tags: Case Reports Source Type: research

High-Grade Neuroendocrine Carcinoma of the Breast With Focal Squamous Differentiation
Primary neuroendocrine carcinoma of the breast is a rare tumor that comprises less than 1% of breast carcinomas, with most patients being in the sixth or seventh decade of their life. In this article, the authors present the case report of a 42-year-old woman with a rapidly growing tumor in her right breast. After clinical staging by physical examination, breast imaging, and thoracoabdominal computed tomography the patient underwent breast-conserving surgery. The histologic results showed a unique type of high-grade, predominantly large-cell neuroendocrine carcinoma with focal abrupt squamous differentiation. The authors a...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Meciarova, I., Sojakova, M., Mego, M., Mardiak, J., Pohlodek, K. Tags: Case Reports Source Type: research

Unusual Histological Evidence of Dysplasia in a Case of Oral Pemphigus Vulgaris: A Potential Diagnostic Challenge
This report describes the management of an unusual case of oral pemphigus vulgaris (PV). The patient was referred for a painful single bullous lesion together with a small proliferative area localized in the soft palate. Histology and direct immunofluorescence data were consistent for PV but disclosed unusual signs of high-grade dysplasia in the proliferative area. At surgical removal of the dysplastic area 1 week after the start of cortisone therapy there was no evidence of dysplasia. Histological signs of high-grade dysplasia in oral mucosa are often associated with concurrent or subsequent carcinoma. However, severe inf...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Gissi, D. B., Tarsitano, A., Baldovini, C., Gabusi, A. Tags: Case Reports Source Type: research

Metastatic Basosquamous Carcinoma: Report of Two Cases and Clinicopathological Considerations
Basosquamous carcinoma is a rare cutaneous tumor considered by some authors as an aggressive type of basal cell carcinoma having a propensity for local recurrence and a potential risk for regional and distant metastatic spread. Herein we present 2 cases of basosquamous carcinoma of head and neck region, with metastatic spread to parotid gland (case 1) and to cervical nodes (case 2). Both patients had recurrence 2 years after initial treatment of the primary lesion (first patient: surgery; second patient: radiotherapy) and at the same time developed regional metastases. We conclude that basosquamous carcinoma must be consid...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Bucci, T., Santoro, A., Pannone, G., Rodriguez, J., Fior, A., Nocini, P. F. Tags: Case Reports Source Type: research

Acid Fast Property of Histoplasma: A Concept Revitalized
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Jain, D. Tags: Images in Pathology Source Type: research

Ciliated Squamous Cell Carcinoma of the Tonsil
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Stenzel, P., Sauer, D., Andersen, P. Tags: Images in Pathology Source Type: research

Neuroepithelial Structure Resembling the Juxtaoral Organ of Chievitz: Usual Morphology in an Unusual Location
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Cheng, E., Cohen, M. A., Scognamiglio, T. Tags: Images in Pathology Source Type: research

Cytomegalovirus Infection of Seminal Vesicles
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Alikhan, M. B., Tesic, V., Taxy, J. B., Antic, T. Tags: Images in Pathology Source Type: research

Ductal Spread Versus High-Grade Prostatic Intraepithelial Neoplasia: A Diagnostic Pitfall
Ductal spread (DS) of acinar adenocarcinoma of the prostate can lead to an incomplete replacement of the benign epithelium by cancer cells, resulting in a lesion that can be indistinguishable from high-grade prostatic intraepithelial neoplasia (HGPIN). Kovi and colleagues demonstrated 30 years ago that there is a significant association between the presence of DS and local extent of invasive adenocarcinoma, making the distinction between DS and HGPIN clinically relevant. However, despite the existence of certain morphologic features that are suggestive of DS, a definitive differentiation between the aforementioned lesions ...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Acosta, A. M., Sharif, A., Groth, J. V., Kajdacsy-Balla, A. Tags: Pitfalls in Pathology Source Type: research

Undifferentiated Nasopharyngeal Carcinoma Mimicking Hodgkin Lymphoma With CD30 Expression
The presence of CD30-expressing Hodgkin-like cells with a background of inflammation and eosinophils in a young adolescent is usually diagnostic of classical Hodgkin lymphoma. Herein we present the case of a 12-year-old boy presenting with enlarged cervical lymph node characterized by the presence of Hodgkin-like cells expressing CD30 and EBV-LMP1 with a Hodgkin-like background. The Hodgkin-like cells were negative for CD15, CD20, CD45, and Pax-5. The tumor cells, however, expressed several cytokeratins, confirming the diagnosis of an undifferentiated carcinoma nasopharyngeal type. This case highlights the importance of po...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Jabbour, M. N., Nassif, S., Chakhachiro, Z. Tags: Pitfalls in Pathology Source Type: research

Triple Hit Lymphoma: Rare Cases With Less Dire Than Usual Prognosis
Triple hit lymphomas are a subset of so-called double hit non-Hodgkin lymphomas exhibiting simultaneous gene translocations/disruption of MYC, BCL2, and BCL6; however, their overlapping morphologic features and complex genetic rearrangements can render classification and prognostication vexing. Clinically triple hit lymphomas are thought to demonstrate aggressive behavior, similar to or worse than that of double hit lymphomas. Only rare reports of long term survivors exist and raise the possibility that unidentified morphologic, immunologic, or cytogenetic differences may impart a less adverse prognosis than current litera...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Kallen, M. E., Alexanian, S., Said, J., Quintero-Rivera, F. Tags: Original Articles Source Type: research