De Novo CD5-Positive Diffuse Large B-Cell Lymphoma: Report of a Case Presenting With Cutaneous Involvement and Featuring Extensive Intravascular Dissemination on Postmortem Examination
We report a case of an 84-year old man who presented with cutaneous lesions, malaise, and B-symptoms. A skin biopsy revealed neoplastic cells within the lumen of dermal vessels. The patient deteriorated rapidly and died. On postmortem examination, lymphadenopathy with diffuse effacement of lymph node architecture, widespread intravascular neoplastic cells in the skin, lungs, gastrointestinal tract, adrenal glands, testes, and kidneys; and rare, isolated neoplastic cells within vessels of liver and central nervous system were noted. Intravascular or intrasinusoidal invasion has been previously reported in earlier series of ...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Ubeda Romero, A., Santonja, C., Blanco Garcia, A., Requena, L., Rodriguez Pinilla, S. M. Tags: Case Reports Source Type: research

Primary Extramedullary Plasmacytoma in the Gastroduodenal Canal Associated With Epstein-Barr Virus-Associated Adenocarcinoma of the Stomach: A Case Report
We report herein a case of gastroduodenal extramedullary plasmacytoma simultaneously complicated by multiple gastric Epstein-Barr virus (EBV)–associated adenocarcinomas. The patient underwent distal gastrectomy to treat an adenocarcinoma occupying the gastric antrum. Histopathological examination revealed a massive submucosal plasma cell proliferation adjacent to the adenocarcinoma involving the pylorus to the duodenal bulb. Lambda immunoglobulin light chain restriction indicated that these plasma cells were monoclonal. Because the clinical investigation revealed no other lymphoid neoplasms, primary extramedullary pl...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Takahashi, T., Morita, T., Matsuno, Y. Tags: Case Reports Source Type: research

Primary Sellar Rhabdomyosarcoma Arising in Association With a Pituitary Adenoma
We describe a case of a 56-year-old woman who presented with right eye ptosis and a pituitary mass, which was resected and diagnosed as atypical pituitary adenoma. Because of residual disease and atypical pathology, the patient received adjuvant radiation. Tumor recurrence was noted after 5 months, and a second resection was performed. Nests of atypical pituitary adenoma cells within an exuberant spindle cell stroma were noted, with areas of presumed radiation necrosis. A second recurrence prompted a third resection. After expert consultation and additional immunohistochemical stains for muscle markers, a diagnosis was ren...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Duncan, V. E., Nabors, L. B., Warren, P. P., Conry, R. M., Willey, C. D., Perry, A., Riley, K. O., Hackney, J. R. Tags: Case Reports Source Type: research

Intraosseous Hibernoma in the Sacrum of an Adult
This report describes the histological features of a discrete lesion in the sacrum of an 84-year-old lady. Biopsy of this lesion demonstrated that it consisted predominantly of multivacuolated lipocytes with a morphological and immunohistochemical profile consistent with brown fat cells. The lesion was diagnosed as an intraosseous hibernoma. This is the 16th report in the English literature of a hibernoma occurring outside of a soft tissue location. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Westacott, L., Collins, A., Dickenson, I. Tags: Case Reports Source Type: research

A Case Report of Bilateral Sarcomatoid Carcinoma of Adrenal Glands With Adrenal Insufficiency
Adrenocortical carcinomas are relatively rare, but they are considered to be highly aggressive malignant tumors. Sarcomatoid carcinomas represent an even more aggressive type. Bilateral malignant adrenal tumors are extraordinary rare, except for those that represent metastatic spread from a primary neoplasm. Here we report a case of a 69-year-old woman who presented symptoms that raised strong suspicions of adrenal insufficiency. Bilateral adrenal masses, identified in the imaging study, were responsible for the clinical manifestation and surgically resected. Surgical specimens of the bilateral adrenal tumors shared histol...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Ishikawa, N., Nagase, M., Takami, S., Araki, A., Ishikawa, N., Koike, C., Shiina, H., Maruyama, R. Tags: Case Reports Source Type: research

High-Grade Neuroendocrine Carcinoma of the Breast With Focal Squamous Differentiation
Primary neuroendocrine carcinoma of the breast is a rare tumor that comprises less than 1% of breast carcinomas, with most patients being in the sixth or seventh decade of their life. In this article, the authors present the case report of a 42-year-old woman with a rapidly growing tumor in her right breast. After clinical staging by physical examination, breast imaging, and thoracoabdominal computed tomography the patient underwent breast-conserving surgery. The histologic results showed a unique type of high-grade, predominantly large-cell neuroendocrine carcinoma with focal abrupt squamous differentiation. The authors a...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Meciarova, I., Sojakova, M., Mego, M., Mardiak, J., Pohlodek, K. Tags: Case Reports Source Type: research

Unusual Histological Evidence of Dysplasia in a Case of Oral Pemphigus Vulgaris: A Potential Diagnostic Challenge
This report describes the management of an unusual case of oral pemphigus vulgaris (PV). The patient was referred for a painful single bullous lesion together with a small proliferative area localized in the soft palate. Histology and direct immunofluorescence data were consistent for PV but disclosed unusual signs of high-grade dysplasia in the proliferative area. At surgical removal of the dysplastic area 1 week after the start of cortisone therapy there was no evidence of dysplasia. Histological signs of high-grade dysplasia in oral mucosa are often associated with concurrent or subsequent carcinoma. However, severe inf...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Gissi, D. B., Tarsitano, A., Baldovini, C., Gabusi, A. Tags: Case Reports Source Type: research

Metastatic Basosquamous Carcinoma: Report of Two Cases and Clinicopathological Considerations
Basosquamous carcinoma is a rare cutaneous tumor considered by some authors as an aggressive type of basal cell carcinoma having a propensity for local recurrence and a potential risk for regional and distant metastatic spread. Herein we present 2 cases of basosquamous carcinoma of head and neck region, with metastatic spread to parotid gland (case 1) and to cervical nodes (case 2). Both patients had recurrence 2 years after initial treatment of the primary lesion (first patient: surgery; second patient: radiotherapy) and at the same time developed regional metastases. We conclude that basosquamous carcinoma must be consid...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Bucci, T., Santoro, A., Pannone, G., Rodriguez, J., Fior, A., Nocini, P. F. Tags: Case Reports Source Type: research

Acid Fast Property of Histoplasma: A Concept Revitalized
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Jain, D. Tags: Images in Pathology Source Type: research

Ciliated Squamous Cell Carcinoma of the Tonsil
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Stenzel, P., Sauer, D., Andersen, P. Tags: Images in Pathology Source Type: research

Neuroepithelial Structure Resembling the Juxtaoral Organ of Chievitz: Usual Morphology in an Unusual Location
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Cheng, E., Cohen, M. A., Scognamiglio, T. Tags: Images in Pathology Source Type: research

Cytomegalovirus Infection of Seminal Vesicles
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Alikhan, M. B., Tesic, V., Taxy, J. B., Antic, T. Tags: Images in Pathology Source Type: research

Ductal Spread Versus High-Grade Prostatic Intraepithelial Neoplasia: A Diagnostic Pitfall
Ductal spread (DS) of acinar adenocarcinoma of the prostate can lead to an incomplete replacement of the benign epithelium by cancer cells, resulting in a lesion that can be indistinguishable from high-grade prostatic intraepithelial neoplasia (HGPIN). Kovi and colleagues demonstrated 30 years ago that there is a significant association between the presence of DS and local extent of invasive adenocarcinoma, making the distinction between DS and HGPIN clinically relevant. However, despite the existence of certain morphologic features that are suggestive of DS, a definitive differentiation between the aforementioned lesions ...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Acosta, A. M., Sharif, A., Groth, J. V., Kajdacsy-Balla, A. Tags: Pitfalls in Pathology Source Type: research

Undifferentiated Nasopharyngeal Carcinoma Mimicking Hodgkin Lymphoma With CD30 Expression
The presence of CD30-expressing Hodgkin-like cells with a background of inflammation and eosinophils in a young adolescent is usually diagnostic of classical Hodgkin lymphoma. Herein we present the case of a 12-year-old boy presenting with enlarged cervical lymph node characterized by the presence of Hodgkin-like cells expressing CD30 and EBV-LMP1 with a Hodgkin-like background. The Hodgkin-like cells were negative for CD15, CD20, CD45, and Pax-5. The tumor cells, however, expressed several cytokeratins, confirming the diagnosis of an undifferentiated carcinoma nasopharyngeal type. This case highlights the importance of po...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Jabbour, M. N., Nassif, S., Chakhachiro, Z. Tags: Pitfalls in Pathology Source Type: research

Triple Hit Lymphoma: Rare Cases With Less Dire Than Usual Prognosis
Triple hit lymphomas are a subset of so-called double hit non-Hodgkin lymphomas exhibiting simultaneous gene translocations/disruption of MYC, BCL2, and BCL6; however, their overlapping morphologic features and complex genetic rearrangements can render classification and prognostication vexing. Clinically triple hit lymphomas are thought to demonstrate aggressive behavior, similar to or worse than that of double hit lymphomas. Only rare reports of long term survivors exist and raise the possibility that unidentified morphologic, immunologic, or cytogenetic differences may impart a less adverse prognosis than current litera...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Kallen, M. E., Alexanian, S., Said, J., Quintero-Rivera, F. Tags: Original Articles Source Type: research

Prevalence of Helicobacter pylori in Gastric Hyperplastic Polyps
Hyperplastic polyps of the stomach are routinely encountered during upper endoscopy and often arise in the setting of abnormal surrounding mucosa, particularly Helicobacter pylori, autoimmune gastritis, and reactive gastropathy. Not infrequently gastroenterologists fail to biopsy the surrounding mucosa, thus determining the underlying etiology of the gastric hyperplastic polyp can be difficult. Recently, the Rodger C. Haggitt Gastrointestinal Pathology Society published guidelines on the use of special stains. The society guidelines indicate that H pylori are not usually present in hyperplastic polyps and special stains in...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Horvath, B., Pai, R. K. Tags: Original Articles Source Type: research

Immunoexpression of Epithelial Mesenchymal Transition Proteins E-Cadherin, {beta}-Catenin, and N-Cadherin in Oral Squamous Cell Carcinoma
Conclusion. OSCC tissues had high levels of EMT phenotype as compared with the normal oral mucosa. This phenotype was characterized by reduced E-cadherin and β-catenin expression and overexpression of N-cadherin. Aberrant localization of the studied proteins was a hallmark for depicting EMT. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Angadi, P. V., Patil, P. V., Angadi, V., Mane, D., Shekar, S., Hallikerimath, S., Kale, A. D., Kardesai, S. G. Tags: Original Articles Source Type: research

Visualization of Grossly Undetectable Breast Tumors by Refixation in Lymph Node Revealing Solution
Conclusion. Postfixation in LNRS enhances the visualization of grossly undetectable breast lesions and it is worthwhile to use it in problematic cases in order to arrive at a more accurate diagnosis. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Bubis, G., Rath-Wolfson, L., Schwartz, A., Girich, S., Koren, R. Tags: Original Articles Source Type: research

Voluntary Second Opinions in Pediatric Bone and Soft Tissue Pathology: A Retrospective Review of 1601 Cases From a Single Mesenchymal Tumor Consultation Service
The diagnosis of bone and soft tissue tumors in children is challenging. These lesions are especially difficult for general pathologists. We reviewed our experience with pediatric mesenchymal tumors sent in consultation to our service, with the goal of identifying issues that most often prompted second-opinion referral. Roughly 16 000 cases were seen in toto, of which 1601 occurred in children. These included 491 bone cases and 1110 soft tissue cases. The cases were referred by private practices/nonacademic medical centers (85%), academic medical centers (8%), and pediatric hospitals (7%). Reasons for referral were (a) sel...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Al-Ibraheemi, A., Folpe, A. L. Tags: Original Articles Source Type: research

Desmoplastic Small Round Cell Tumor: Pathology, Genetics, and Potential Therapeutic Strategies
Desmoplastic small round cell tumor (DSRCT) is an aggressive small round cell neoplasm which predominantly occurs intra-abdominally in adolescents and young adults with a male predominance, and which is characterized by a recurrent t(11;22)(p13;q12) translocation leading to formation of the EWSR1-WT1 fusion gene, which generates a chimeric protein with transcriptional regulatory activity. Histologically, DSRCT has a characteristic morphology, of islands of monotonous small cells within prominent sparsely cellular fibroblastic stroma, and immunohistochemically it shows polyphenotypic multidirectional differentiation, with e...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Thway, K., Noujaim, J., Zaidi, S., Miah, A. B., Benson, C., Messiou, C., Jones, R. L., Fisher, C. Tags: Review Source Type: research

Chordoid Glioma of Third Ventricle With an Epidermoid Cyst: Coexistence or Common Histogenesis?
We report a case of CG in a 45-year-old male coexisting with an epidermoid cyst in the third ventricle. Ultrastructural examination of the CG revealed microvilli, junctional complexes, and intermediate filaments within the cytoplasm suggesting origin from specialized ependyma. The association of the 2 lesions appears coincidental as convincing evidence for a common histogenesis was not found. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Poyuran, R., Mahadevan, A., Sagar, B. K. C., Saini, J., Srinivas, D. Tags: Case Reports Source Type: research

Dirofilariasis Presenting as an Infiltrative Mass in the Right Buccal Space
Dirofilariasis is caused by filarial nematodes (roundworms) of the genus Dirofilaria. Dirofilariasis of the oral mucosa is very rare. Herein, we report a case of a 79-year-old man who had a slowly growing infiltrative mass in the right buccal space. Histopathologic examination showed an inflammatory infiltrate with eosinophilia, histiocytes, and small organisms (0.2-0.3 mm). Digital images were sent to the Centers for Disease Control and Prevention, which identified the parasite as a nematode in the genus Dirofilaria. It appeared to be dead and degenerating, but external, fine longitudinal cuticular ridges and the presence...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Velez-Perez, A., Liang, L., Syklawer, E., Chavez, V., Zhang, S., Wanger, A. Tags: Case Reports Source Type: research

Ameloblastic Fibrosarcoma of the mandible evolving from a prior Ameloblastic Fibroma after two years: an unusual finding
This article describes the clinical and radiographic features, histological characteristics, immunohistochemical findings, and surgical treatment of the tumor. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Bertoni, F., Del Corso, G., Bacchini, P., Marchetti, C., Tarsitano, A. Tags: Case Reports Source Type: research

Primary Colon Adenosquamous Carcinoma in a Patient With Lynch Syndrome: A New Histologic Subtype Associated With Microsatellite Instability?
We report a case of a 53-year-old woman who presented with rectal bleeding and a 9.5 cm hemicircumferential ascending colon mass. Histology revealed adenosquamous carcinoma (ASC), a rare subtype comprised of malignant squamous and glandular elements. Immunohistochemistry revealed loss of MLH1/PMS2 expression and retained MSH2/MSH6 expression in squamous and glandular components, indicative of microsatellite instability (MSI). MSI is caused by loss-of-function defects in DNA mismatch repair genes, leading to increased susceptibility to a variety of neoplasms; the role of MSI in colorectal ASC is unknown. The tumor was negat...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Duncan, V. E., Harada, S., Stevens, T. M. Tags: Case Reports Source Type: research

Granulomatous Insulitis as a Cause of Acute-Onset Insulin-Dependent Diabetes Mellitus in a Patient With a Pancreatic Endocrine Carcinoma
We report a unique case of granulomatous insulitis in a patient with an endocrine tumor of the pancreas that clinically manifested as acute-onset insulin-dependent diabetes mellitus. Granulomata were present in islets with complete disappearance of β cells, as well as in the primary tumor, metastases, and lymph nodes. We postulate that these granulomata represent a sarcoid-like reaction to the tumor with secondary injury to nonneoplastic endocrine cells through a mechanism of molecular mimicry. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Saab, J., Qin, L., Jessurun, J. Tags: Case Reports Source Type: research

Ciliated Foregut Cyst of the Common Hepatic Duct: An Unusual Mimic of a Type II Choledochal Cyst
Ciliated foregut cysts typically arise in the liver and pancreas, with rare cases reported to arise in the gallbladder wall. Herein, we describe an unusual case of a patient with a ciliated foregut cyst arising from the wall of the common hepatic duct, which has not been reported previously. As a result of its unique anatomical location, the cyst was mistaken for a type II choledochal cyst on preoperative imaging. The cyst caused intermittent biliary obstruction that resolved following surgical resection. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Cottreau, J., Costa, A., Walsh, M., Arnason, T. Tags: Case Reports Source Type: research

Hepatocellular Adenoma of the Placenta With Updated Immunohistochemical and Molecular Markers: A Case Report
We describe the clinicopathological, immunohistochemical, and molecular features of an unusual case of a hepatocellular adenoma of the placenta presenting as a subchorionic intervillous mass lesion in a diamnionic dichorionic placenta. A well-circumscribed 0.8 cm round nodule was identified in one of the twin placental discs, wherein, on microscopic review, the lesional cells morphologically and immunophenotypically resembled fetal hepatocytes. Given the rarity of this lesion, we performed an updated immunohistochemical and molecular analysis, including makers for β-catenin activation and well-differentiated hepatocel...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Yee, E. U., Hale, G., Liu, X., Lin, D. I. Tags: Case Reports Source Type: research

Mesonephric (Wolffian) Pseudoendometrioid Carcinoma of the Broad Ligament, Arising From a Papillary Cystadenoma
This article describes the case of a 70-year-old woman with an adnexal cystadenocarcinoma located in the right broad ligament and displaying a striking resemblance to a well-differentiated endometrioid adenocarcinoma. The uniqueness of this pseudoendometrioid carcinoma lies in the fact that its mesonephric nature is revealed by the origin from a papillary cystadenoma of the broad ligament, where remnants of the mesonephric duct are seated, and the immunohistochemical profile, particularly a uniform negativity for estrogen and progesterone receptors, apical-luminal positivity for CD10, and strong nuclear positivity for GATA...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Moerman, P., Amant, F., Vergote, I. Tags: Case Reports Source Type: research

Follicular Dendritic Cell Sarcoma of Appendix Presenting as Acute Appendicitis: An Exceptionally Rare Case Report
Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that originates from dendritic cells of lymphoid follicles and shows low to intermediate malignant potential. It most commonly arises from lymph nodes, but may originate from a variety of extranodal sites. FDCS of appendix is exceptionally rare, and only a single case has been reported. Herein, we describe the clincopathological features of a case of FDCS originating from appendix with emphasis on being able to recognize this rare neoplasm in the context of the differential diagnosis of more common intraabdominal spindle cell tumors. (Source: International Journal...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Ahmed, A., Ud Din, N., Alvi, A. R., Rubin, B. P. Tags: Case Reports Source Type: research

Coexistence of Multiple Ileal Neuroendocrine Tumors and Idiopathic Myointimal Hyperplasia of Mesenteric Veins: Coincidence or Consequence? Case Report and Review of Literature
In the present case, we report the association of multiple ileal neuroendocrine tumors and idiopathic myointimal hyperplasia of the mesenteric veins, 2 rare conditions that could have an etiopathogenetic relationship. Idiopathic myointimal hyperplasia of mesenteric veins implies a near-total obliteration of venular vessels, which can lead to hypoxic disorders. Hypoxia in tumors is associated with increased metastatic potential and resistance to radiotherapy and chemotherapy. Herein we speculated on the existence of a relationship between hypoxia and multiple location of neuroendocrine tumors. (Source: International Journal...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Guadagno, E., Del Basso De Caro, M., Del Prete, E., DArmiento, F. P., Campione, S. Tags: Case Reports Source Type: research

Renal Oncocytoma With Perinephric Fat Invasion
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Williamson, S. R. Tags: Images in Pathology Source Type: research

Annulate Lamellae in a Desmoplastic Small Round Cell Tumor
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Alfaro-Cervello, C., Soriano-Navarro, M., Cebrian-Silla, A., Forteza-Vila, J. Tags: Images in Pathology Source Type: research

Well-Differentiated Liposarcoma With Hibernoma-Like Morphology
Well-differentiated liposarcoma (WDL) can show a morphologic spectrum, including lipoma-like, sclerosing and inflammatory subtypes. It does not metastasize but can dedifferentiate, acquiring metastatic potential. Hibernomas are benign neoplasms that show variable differentiation toward brown fat, and can sometimes occur in the abdomen or retroperitoneum. We illustrate a case of retroperitoneal WDL that showed extensive hibernoma-like morphology, with sheets of multivacuolated adipocytes of varying sizes, with abundant cytoplasm and numerous lipid vacuoles or granular eosinophilic cytoplasm. However, very focally there were...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Hallin, M., Schneider, N., Thway, K. Tags: Pitfalls in Pathology Source Type: research

CD138 Expression Is Observed in the Urothelial Epithelium and in Various Urothelial Carcinomas, and Cannot Be Evidence for Plasmacytoid Urothelial Carcinoma
CD138 (syndecan-1) immunoexpression has been reported to be specific for the plasmacytoid variant of urothelial carcinomas (UCs). The aim of this study was to examine the utility of CD138 immunohistochemistry for diagnosing the plasmacytoid variant of UCs. The extent and intensity of CD138 immunostaining were evaluated in 22 infiltrating UCs, 2 other infiltrating carcinomas, 15 noninvasive urothelial lesions, 3 other benign lesions, and perilesional normal tissues. CD138 immunostaining of the normal urothelial epithelium was universally diffuse and strong. In addition, all 42 cases of urinary tract lesions exhibited positi...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Goto, K. Tags: Original Articles Source Type: research

Clinicopathological Significance of the Proliferation Markers Ki67, RacGAP1, and Topoisomerase 2 Alpha in Breast Cancer
Conclusion. This study showed that the overexpressions of Ki67, RacGAP1, and TOP2a affect the prognosis adversely, thus to develop target therapies against RacGAP1 and TOP2a as well as using Ki67 as a part of routine pathology practice might be beneficial in breast cancer therapy and prediction of prognosis. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Sahin, S., Isık Gönül, I., Cakır, A., Seckin, S., Uluoglu, O. Tags: Original Articles Source Type: research

A Comparative Study of Intraoperative Cytology and Frozen Sections of Sclerosing Pneumocytoma
In this study, we review and compare the intraoperative cytology and frozen section of 14 cases of SP. SP is characterized by containing 2 cell types: round stromal cells and cuboidal surface cells. The round stromal cells were small with uniform nuclei and inconspicuous nucleoli. The cuboidal surface cells were more differentiated into type II pneumocytes and showed slightly larger in size with intranuclear inclusions. The immunocytochemical double-labeling staining could display 2 distinct population of vimentin-positive round stromal cells and cytokeratin 7–positive cuboidal surface cells. Recognition of the cytol...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Wu, C.-Y., Wang, J., Chang, N.-Y. Tags: Original Articles Source Type: research

Podoplanin Expression Is Correlated With the Progression of Chronic Discoid Lupus Erythematosus to Lip Squamous Cell Carcinoma
The objective of this study was to determine the immunoexpression of podoplanin in samples of patients with DLE and its correlation with the risk of progression to LSCC. In a retrospective study, podoplanin expression was determined using immunohistochemistry in samples from 52 patients with DLE, including 44 patients with untransformed DLE and 8 patients with malignant transformed DLE. Ten samples of normal oral mucosa and 10 samples of LSCC were used as normal and cancer controls, respectively. The results showed that podoplanin expression was observed in 12 of 44 (27.3%) patients with untransformed DLE and in 7 of 8 (87...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Gao, X., Ma, L., Zhou, Z., Jian, X., Liu, W. Tags: Original Articles Source Type: research

Cyclin D1 Expression in Ectomesenchymal Chondromyxoid Tumor of the Anterior Tongue
Ectomesenchymal chondromyxoid tumor (ECT) is a rare benign tumor of uncertain lineage, which almost exclusively affects the anterior tongue. Herein, we report 2 cases of ECT occurring in 58- and 56-year-old males on the right and on the left side of the dorsum of the anterior tongue, measuring 18 mm and 10 mm, respectively. Despite positive resection margin in one case, none of the tumors recurred during follow-up of 6 and 5 years. Microscopically, both tumors had lobular architecture with a mixture of solid, microcystic, and chondromyxoid areas. The tumor cells were polygonal or elongated and showed mild atypia in one cas...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Laco, J., Mottl, R., Höbling, W., Ihrler, S., Grossmann, P., Skalova, A., Ryska, A. Tags: Original Articles Source Type: research

Autoantibodies in Autoimmune Liver Diseases--Methods of Detection and Interpretation: An Update for the Reporting Pathologist
Autoimmune liver disease (AILD) is a type of chronic liver disease with autoimmune etiology. The diagnosis of the disease is multipronged and detection of autoantibodies in AILDs is an important diagnostic tool and it also helps in the classification of the disease. There are multiple autoantibodies that are detected in AILDs but none is diagnostic. Moreover, these autoantibodies are detected in many other pathological and nonpathological conditions. So the significance of seropositivity for these autoantibodies should be known by both the pathologists as well as the clinicians. In addition, there is prognostic significanc...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Mitra, S., Minz, R. W. Tags: Review Source Type: research

Pindborg Tumor Presenting as a Nasal Polyp: Immunohistology and Ultrastructural Features of a Rare Case, With Review of the Literature
We present a rare case of calcifying epithelial odontogenic tumor presenting as a nasal polyp, posing a diagnostic difficulty. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - August 4, 2016 Category: Pathology Authors: Mitra, S., Kaur, G., Nada, R., Mohindra, S. Tags: Case Reports Source Type: research

Epithelial Inclusion Cyst in Conjunctival Melanoma
Conjunctival melanoma is the second most common conjunctival malignancy. Its differential diagnosis with other conjunctival melanocytic neoplasms is inherently difficult. The presence of epithelial cysts is a useful feature in conjunctival tumors and favors a benign lesion. Herein 2 cases of conjunctival melanoma with cysts are presented. To the best of our knowledge, this is the first series of conjunctival melanoma with epithelial inclusion cysts. This series emphasizes the importance of considering several malignant features when reviewing conjunctival melanocytic lesions, as malignancy can exist even in the presence of...
Source: International Journal of Surgical Pathology - August 4, 2016 Category: Pathology Authors: Esposito, E., Zoroquiain, P., Mastromonaco, C., Morales, M. C., Belfort Neto, R., Burnier, M. Tags: Case Reports Source Type: research

Anaplastic Sarcoma of the Kidney: A Rare Unique Renal Neoplasm
Anaplastic sarcoma of the kidney (ASK) is an extremely rare tumor, which usually presents as a large renal mass. Microscopically, the tumor is composed of pleomorphic mesenchymal spindle cells with marked atypia, associated with chondroid differentiation and focal round primitive mesenchymal cells. Herein, we present a case of anaplastic sarcoma of the kidney in a 3-year-old female, who presented with a large abdominal mass. To the best of our knowledge, less than 25 cases are reported in the literature. In addition, this is the first case reported from the Middle East. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - August 4, 2016 Category: Pathology Authors: Arabi, H., Al-Maghraby, H., Yamani, A., Yousef, Y., Huwait, H. Tags: Case Reports Source Type: research

Metastatic Renal Cell Carcinoma in a Hepatic Hemangioma: A Case Report and Review of the Literature
We report the case of 55-year-old female with biopsy-proven clear cell renal cell carcinoma with a suspicious lesion found in the liver who presented for right radical nephrectomy and partial hepatectomy. Histologic evaluation of the hepatic specimen demonstrated metastatic renal cell carcinoma within a hepatic hemangioma. Herein we provide a review of the literature for this uncommon scenario. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - August 4, 2016 Category: Pathology Authors: Cohen, J., Meunier, R., Jamshed, S., Karam, A. R., Yates, J., Wang, X., LaFemina, J. Tags: Case Reports Source Type: research

Malakoplakia Associated With Multiple Adenomas of the Colon: An Extremely Rare Incidental Finding
Malakoplakia in the colon has been described either as part of a systemic disease with a diffuse presentation or as a rare incidental finding associated usually with an adenocarcinoma. To our knowledge, the association of malakoplakia with colonic adenoma is very rare and only 5 cases, including the present case, have been reported so far. Here, we describe a case of malakoplakia coexisting with multiple sigmoid colonic adenomas in a 67-year-old patient without any underlying inflammatory or infectious disease and with no history of immunosuppressive treatment. As far as we are concerned, this is the first description of m...
Source: International Journal of Surgical Pathology - August 4, 2016 Category: Pathology Authors: Zanelli, M., Ragazzi, M., Serra, S., Bellafiore, S., Ascani, S., De Marco, L. Tags: Case Reports Source Type: research

Primitive Neuroectodermal Tumor of the Stomach: A Case Report
Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is a highly aggressive small round cell tumor that mainly occurs in the bone or soft tissue of children or young adults but is extremely rare in the stomach. A 55-year-old man presented with melena and anemia. On endoscopy, an ulcerofungating mass was observed in the high body and total gastrectomy was performed. Histologically, the mass consisted of small round cells with scanty cytoplasm and inconspicuous nucleoli. They often formed perivascular pseudorosettes and multinucleated giant cells were frequently observed. The tumor cells strongly expressed CD99, FLI1, and...
Source: International Journal of Surgical Pathology - August 4, 2016 Category: Pathology Authors: Song, M. J., An, S., Lee, S. S., Kim, B. S., Kim, J. Tags: Case Reports Source Type: research

Lipid-Rich Carcinoma of the Breast With Unusual Clinical and Histopathological Features
We report an unusual case of lipid-rich carcinoma with morphological and immunophenotypical features different from those of cases reported so far in the literature. The index case underscores the fact that there is no consensus with regard to the exact nature of this tumor. Hence, larger studies are needed to draw meaningful conclusions. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - August 4, 2016 Category: Pathology Authors: Gaspar, B. L., Kumar, M., Gupta, R., Garg, R., Singh, R., Vasishta, R. K. Tags: Case Reports Source Type: research

Is It a Dog? Is It a Sea Monster? Is it . . . ?
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - August 4, 2016 Category: Pathology Authors: Pandian, A., Pai, S. A. Tags: Images in Pathology Source Type: research

The Fragile Intraductal Lesions of the Prostate
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - August 4, 2016 Category: Pathology Authors: Acosta, A. M., Gallegos, M. Tags: Images in Pathology Source Type: research

Thyrosaurus Colloidus
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - August 4, 2016 Category: Pathology Authors: Marcus, A., Giorgadze, T. Tags: Images in Pathology Source Type: research

Mimics of Mammary Paget Disease: A Rogues Gallery
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - August 4, 2016 Category: Pathology Authors: Hoda, S., Cheng, E. Tags: Images in Pathology Source Type: research