Perspectives on testicular sex cord –stromal tumors and those composed of both germ cells and sex cord–stromal derivatives with a comparison to corresponding ovarian neoplasms
Sex cord –stromal tumors (SCSTs) are the second most frequent category of testicular neoplasms, accounting for approximately 2% to 5% of cases. Both genetic and epigenetic factors account for the differences in frequency and histologic composition between testicular and ovarian SCSTs. For example, large ce ll calcifying Sertoli cell tumor and intratubular large cell hyalinizing Sertoli cell neoplasia occur in the testis but have not been described in the ovary. In this article, we discuss recently described diagnostic entities as well as inconsistencies in nomenclature used in the recent World Health Organization classif...
Source: Human Pathology - April 23, 2017 Category: Pathology Authors: Lawrence M. Roth, Bingjian Lyu, Liang Cheng Tags: Progress in pathology Source Type: research
Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms
Sex cord-stromal tumors (SCSTs) are the second most frequent category of testicular neoplasms, accounting for approximately 2 –5% of cases. Both genetic and epigenetic factors account for the differences in frequency and histologic composition between testicular and ovarian SCSTs. For example, large cell calcifying Sertoli cell tumor and intratubular large cell hyalinizing Sertoli cell neoplasia occur in the testis but h ave not been described in the ovary. In this article, we discuss recently described diagnostic entities as well as inconsistencies in nomenclature used in the recent World Health Organization classificat...
Source: Human Pathology - April 23, 2017 Category: Pathology Authors: Lawrence M. Roth, Bingjian Lyu, Liang Cheng Tags: Progress in pathology Source Type: research
An adolescent with large cell calcifying sertoli cell tumor of the testis and undiagnosed Carney Complex: A case report
We present a unique case and literature review of CNC in which two neoplasms characteristic of this complex were initially diagnosed through cytological fine needle aspirate specimens, leading to the identification of CNC, with subsequent surgical and cytogenetic confirmation. Diagn. Cytopathol. 2017. © 2017 Wiley Periodicals, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - February 28, 2017 Category: Pathology Authors: Frida Rosenblum, Richard Gabriel Koenig, Fady M. Mikhail, John R. Porterfield, Jeffrey W. Nix, Isam ‐Eldin A. Eltoum Tags: Brief Report Source Type: research
Large cell calcifying Sertoli cell tumor of the testis
Dear Editor: Large cell calcifying Sertoli cell tumor of the testis (LCCSCT) is a rare sex cord-stromal tumor that is usually benign1,2; however, recently there (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - February 20, 2017 Category: Journals (General) Tags: ISSUE 5 Source Type: research
The role of beta-catenin mutation and SOX9 expression in sex cord-stromal tumours of the testis
AbstractThe WHO classification of testis tumours includes the group of sex cord-stromal tumours. They are divided into several histological types, i.e. Leydig cell (LCT) and Sertoli cell tumours (SCT). Based on the physiological expression of β-catenin in normal testis/Sertoli cells, it was previously shown that SCT can carry a β-catenin mutation, causing a nuclear positivity for β-catenin and cyclin D1. Furthermore, it could be shown that the stabilization of β-catenin in Sertoli cells causes the loss of the Sertoli cell marker SOX9 . We wanted to know whether the stabilization of β-catenin in sex cord-stromal tumour...
Source: Virchows Archiv - February 15, 2017 Category: Pathology Source Type: research
Generation and characteristics of human Sertoli cell line immortalized by overexpression of human telomerase.
In this study, we have for the first time reported a stable human Sertoli cell line, namely hS1 cells, by overexpression of human telomerase. The hS1 cells expressed a number of hallmarks for human Sertoli cells, including SOX9, WT1, GDNF, SCF, BMP4, BMP6, GATA4, and VIM, and they were negative for 3β-HSD, SMA, and VASA. Higher levels of AR and FSHR were observed in hS1 cells compared to primary human Sertoli cells. Microarray analysis showed that 70.4% of global gene profiles of hS1 cells were similar to primary human Sertoli cells. Proliferation assay demonstrated that hS1 cells proliferated rapidly and they could be pa...
Source: Oncotarget - February 4, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Testicular enlargement in a pre-pubertal boy with adrenocortical tumour.
Authors: Korwutthikulrangsri M, Wattanatranon D, Teeraratkul S, Wijarn P, Mahachoklertwattana P, Poomthavorn P
Abstract
Adrenocortical tumours are rare in children. Virilisation caused by overproduction of adrenal androgens is the most common presentation. The testes of pre-pubertal boys with this tumour are usually small or of pre-pubertal size. A 4.8-year-old boy with an adrenocortical tumour and symmetrical pubertal-sized testes is reported. The serum testosterone level was 204 nmol/L (<0.7), dehydro-epiandrosterone-sulphate 56.7 μmol/L (<1.5) and luteinising and follicle-stimulating hormones wer...
Source: Paediatrics and international child health - January 25, 2017 Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
The World Health Organization 2016 classification of testicular non ‐germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel
The World Health Organization (WHO) released a new tumour classification for the genitourinary system in early 2016 after consensus by pathologists with expertise in these organs. It utilized the framework of the 2004 classification, and incorporated the most up‐to‐date information concerning these tumours. In testicular tumours, the majority of the changes occurred in the nomenclature and classification of germ cell tumours; however, several modifications were also made for non‐germ cell tumours. Among sex cord–stromal tumours, sclerosing Sertoli cell tumour (SCT) is no longer recognized as a separate entity but a...
Source: Histopathology - December 22, 2016 Category: Pathology Authors: Muhammad T Idrees, Thomas M Ulbright, Esther Oliva, Robert H Young, Rodolfo Montironi, Lars Egevad, Daniel Berney, John R Srigley, Jonathan I Epstein, Satish K Tickoo, Tags: Review Source Type: research
Comparative Immunomorphology of Testicular Sertoli and Sertoliform Tumors
Sertoli cell (SC) and sertoliform tumors of the testis are very uncommon; for this reason their differential diagnosis and classification can be challenging. We applied an extensive immunophenotypic panel that included androgenic hormones, enzymes and receptors, neuroendocrine, lineage and genitourinary markers to a series of these lesions to determine if and which immunostains can aid in their diagnostic workup. Study cases included: 2 androgen insensitivity syndrome associated SC-adenomas, 3 SC tumors not otherwise specified (SCT-NOS), 3 sclerosing-SCT, 2 large cell calcifying-SCT, 1 SCT with heterologous-sarcomatous ele...
Source: Human Pathology - December 6, 2016 Category: Pathology Authors: Hector Mesa, Scott Gilles, Milton W. Datta, Paari Murugan, Wendy Larson, Susan Dachel, Juan C. Manivel Tags: Original contribution Source Type: research
Histological, immunohistochemical, and morphometric study of peritubular cells and mast cells in the testicular interstitium of azoospermic men
Conclusion
The present data signify complex cell interactions in cases of testicular dysfunction within the interstitial compartment. (Source: Egyptian Journal of Histology)
Source: Egyptian Journal of Histology - December 1, 2016 Category: Cytology Tags: Original articles Source Type: research
Histological, immunohistochemical, and morphometric study of peritubular cells and mast cells in the testicular interstitium of azoospermic men
Conclusion: The present data signify complex cell interactions in cases of testicular dysfunction within the interstitial compartment. (Source: Egyptian Journal of Histology)
Source: Egyptian Journal of Histology - December 1, 2016 Category: Cytology Tags: Original articles Source Type: research
Response to the anastrozole treatment in a case with peutz-jeghers syndrome who was detected to have large cell calcifying sertoli cell tumor and developed pre-pubertal gynecomastia.
RESPONSE TO THE ANASTROZOLE TREATMENT IN A CASE WITH PEUTZ-JEGHERS SYNDROME WHO WAS DETECTED TO HAVE LARGE CELL CALCIFYING SERTOLI CELL TUMOR AND DEVELOPED PRE-PUBERTAL GYNECOMASTIA.
J Clin Res Pediatr Endocrinol. 2016 Nov 22;:
Authors: Koç Yekedüz M, Şıklar Z, Burgu B, Kuloğlu Z, Kocaay P, Çamtosun E, İsakoca M, Kansu A, Soygür T, Berberoğlu M
Abstract
Peutz-Jeghers Syndrome (PJS) is inherited as an autosomal dominant trait which is characterized by multiple gastrointestinal hamartomatous polyps, mucocutaneous pigmentation, and an increased risk of neoplasm. Large Cell C...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - November 24, 2016 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
Gonadal tumour risk in 292 phenotypic female patients with disorders of sex development containing Y chromosome or Y ‐derived sequence
ConclusionDisorders of sex development patients with Y chromosome materials have a significantly increased risk of GCTs. Gonadoblastoma and dysgerminoma/seminoma are the most prevalent GCTs and 46, XY PGD carries the highest tumour presence and malignancy risk. AIS could postpone bilateral gonadectomy until or after adolescence, while others with streak gonads should undergo surgery as soon as diagnosis. Specific serum tumour markers could be used in predicting GCTs and monitoring. Optimal care and close follow‐up are required. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - November 9, 2016 Category: Endocrinology Authors: He Huang, Chunqing Wang, Qinjie Tian Tags: Original Article Source Type: research
Genetics and Genomics of Ovarian Sex Cord-Stromal Tumors.
Abstract
Ovarian sex cord-stromal tumors represent ~8% of malignant ovarian tumors. The most common are granulosa cell tumors (GCT) which account for ~90% of malignant sex cord-stromal tumors. Recent studies have unravelled the key genomic and genetic events contributing to their pathogenesis. Sex cord-stromal tumors are found in the hereditary syndromes: Peutz-Jeghers Syndrome, Ollier disease and Maffucci syndrome, and DICER1 syndrome. Genomic studies have largely been limited to GCT where a number of recurring chromosomal abnormalities (monsomy and trisomy) have been identified although their contributio...
Source: Clinical Genetics - November 3, 2016 Category: Genetics & Stem Cells Authors: Fuller PJ, Leung D, Chu S Tags: Clin Genet Source Type: research
The WHO 2016 Classification of Testicular Non ‐Germ Cell Tumours: A Review and Update from the International Society of Urological Pathology Testis Consultation Panel
This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - October 31, 2016 Category: Pathology Authors: Muhammad T. Idrees, Thomas M. Ulbright, Esther Oliva, Robert H Young, Rodolfo Montironi, Lars Egevad, Daniel Berney, John R Srigley, Jonathan I Epstein, Satish K. Tickoo Tags: Review Source Type: research
