Ubiquitin proteasome system and autophagy associated proteins in human testicular tumors
Tissue Cell. 2021 Feb 26;71:101513. doi: 10.1016/j.tice.2021.101513. Online ahead of print.ABSTRACTUbiquitin proteasome sytem (UPS) and autophagy govern protein quality control by degradation and clearance of damaged proteins. Many proteins working in these pathways such as p97/VCP, Ubiquitin (Ub), Jab1/CSN5, p62, LC3B and Beclin 1 are known to be essential for different pathological conditions, especially in cancer, but their expression in human testicular tumors has not been characterized yet. In the present study, we aimed to investigate the expression of UPS (p97/VCP, Ubiquitin, Jab1/CSN5) and autophagic (p62, LC3B, Be...
Source: Tissue and Cell - March 7, 2021 Category: Cytology Authors: Hilal Nakkas Berrak Gumuskaya Ocal Seyma Kipel Gulben Akcan Cansu Sahin Arslan Ardicoglu Sevil Cayli Source Type: research
Ubiquitin proteasome system and autophagy associated proteins in human testicular tumors
Tissue Cell. 2021 Feb 26;71:101513. doi: 10.1016/j.tice.2021.101513. Online ahead of print.ABSTRACTUbiquitin proteasome sytem (UPS) and autophagy govern protein quality control by degradation and clearance of damaged proteins. Many proteins working in these pathways such as p97/VCP, Ubiquitin (Ub), Jab1/CSN5, p62, LC3B and Beclin 1 are known to be essential for different pathological conditions, especially in cancer, but their expression in human testicular tumors has not been characterized yet. In the present study, we aimed to investigate the expression of UPS (p97/VCP, Ubiquitin, Jab1/CSN5) and autophagic (p62, LC3B, Be...
Source: Tissue and Cell - March 7, 2021 Category: Cytology Authors: Hilal Nakkas Berrak Gumuskaya Ocal Seyma Kipel Gulben Akcan Cansu Sahin Arslan Ardicoglu Sevil Cayli Source Type: research
Ubiquitin proteasome system and autophagy associated proteins in human testicular tumors
Tissue Cell. 2021 Feb 26;71:101513. doi: 10.1016/j.tice.2021.101513. Online ahead of print.ABSTRACTUbiquitin proteasome sytem (UPS) and autophagy govern protein quality control by degradation and clearance of damaged proteins. Many proteins working in these pathways such as p97/VCP, Ubiquitin (Ub), Jab1/CSN5, p62, LC3B and Beclin 1 are known to be essential for different pathological conditions, especially in cancer, but their expression in human testicular tumors has not been characterized yet. In the present study, we aimed to investigate the expression of UPS (p97/VCP, Ubiquitin, Jab1/CSN5) and autophagic (p62, LC3B, Be...
Source: Tissue and Cell - March 7, 2021 Category: Cytology Authors: Hilal Nakkas Berrak Gumuskaya Ocal Seyma Kipel Gulben Akcan Cansu Sahin Arslan Ardicoglu Sevil Cayli Source Type: research
Ubiquitin proteasome system and autophagy associated proteins in human testicular tumors
Tissue Cell. 2021 Feb 26;71:101513. doi: 10.1016/j.tice.2021.101513. Online ahead of print.ABSTRACTUbiquitin proteasome sytem (UPS) and autophagy govern protein quality control by degradation and clearance of damaged proteins. Many proteins working in these pathways such as p97/VCP, Ubiquitin (Ub), Jab1/CSN5, p62, LC3B and Beclin 1 are known to be essential for different pathological conditions, especially in cancer, but their expression in human testicular tumors has not been characterized yet. In the present study, we aimed to investigate the expression of UPS (p97/VCP, Ubiquitin, Jab1/CSN5) and autophagic (p62, LC3B, Be...
Source: Tissue and Cell - March 7, 2021 Category: Cytology Authors: Hilal Nakkas Berrak Gumuskaya Ocal Seyma Kipel Gulben Akcan Cansu Sahin Arslan Ardicoglu Sevil Cayli Source Type: research
Ubiquitin proteasome system and autophagy associated proteins in human testicular tumors
Tissue Cell. 2021 Feb 26;71:101513. doi: 10.1016/j.tice.2021.101513. Online ahead of print.ABSTRACTUbiquitin proteasome sytem (UPS) and autophagy govern protein quality control by degradation and clearance of damaged proteins. Many proteins working in these pathways such as p97/VCP, Ubiquitin (Ub), Jab1/CSN5, p62, LC3B and Beclin 1 are known to be essential for different pathological conditions, especially in cancer, but their expression in human testicular tumors has not been characterized yet. In the present study, we aimed to investigate the expression of UPS (p97/VCP, Ubiquitin, Jab1/CSN5) and autophagic (p62, LC3B, Be...
Source: Tissue and Cell - March 7, 2021 Category: Cytology Authors: Hilal Nakkas Berrak Gumuskaya Ocal Seyma Kipel Gulben Akcan Cansu Sahin Arslan Ardicoglu Sevil Cayli Source Type: research
Ubiquitin proteasome system and autophagy associated proteins in human testicular tumors
Tissue Cell. 2021 Feb 26;71:101513. doi: 10.1016/j.tice.2021.101513. Online ahead of print.ABSTRACTUbiquitin proteasome sytem (UPS) and autophagy govern protein quality control by degradation and clearance of damaged proteins. Many proteins working in these pathways such as p97/VCP, Ubiquitin (Ub), Jab1/CSN5, p62, LC3B and Beclin 1 are known to be essential for different pathological conditions, especially in cancer, but their expression in human testicular tumors has not been characterized yet. In the present study, we aimed to investigate the expression of UPS (p97/VCP, Ubiquitin, Jab1/CSN5) and autophagic (p62, LC3B, Be...
Source: Tissue and Cell - March 7, 2021 Category: Cytology Authors: Hilal Nakkas Berrak Gumuskaya Ocal Seyma Kipel Gulben Akcan Cansu Sahin Arslan Ardicoglu Sevil Cayli Source Type: research
A phase 1 trial of the histone deacetylase inhibitor AR-42 in patients with neurofibromatosis type 2-associated tumors and advanced solid malignancies
ConclusionSingle-agent AR-42 is safe and well tolerated. Further studies may consider AR-42 in a larger cohort of patients with NF2 or in combination with other agents in advanced solid tumors.Trial registrationNCT01129193, registered 5/24/2010. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - January 25, 2021 Category: Cancer & Oncology Source Type: research
Sex Cord Tumour with Annular Tubules-An Unusual Case of Abdominal Pain.
CONCLUSION: SCTAT is a slow-growing tumour that occasionally exhibits malignant behaviour with metastatic potential, albeit many years following initial diagnosis. SCTAT should be included in the differential diagnosis of sex cord tumours.
PMID: 33288481 [PubMed - as supplied by publisher] (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - December 9, 2020 Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Serum levels of microRNA-371a-3p are not elevated in testicular tumours of non-germ cell origin
ConclusionClinically, the test might be of value in preoperative characterization of benign testicular tumours eligible for conservative surgery. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 16, 2020 Category: Cancer & Oncology Source Type: research
Sertoli cell tumor/mixed germ cell-stromal cell tumor as separate neoplasms in a bilaterally cryptorchid dog.
Abstract
An 11-year-old miniature poodle dog was presented with bilateral flank alopecia, gynecomastia, severe thrombocytopenia, and preputial edema. Based on characteristic clinical and hematological findings of hyperestrogenism and the presence of a caudal abdominal mass, a Sertoli cell tumor (SCT) was diagnosed. After a platelet concentrate transfusion, the SCT was surgically removed in addition to an atrophied contralateral testicle containing a mixed germ cell-stromal cell tumor. Recovery was uneventful. This combination of different neoplasms in separate testicles has yet to be documented. Key clinic...
Source: The Canadian Veterinary Journal - August 31, 2020 Category: Veterinary Research Authors: DeForge TL Tags: Can Vet J Source Type: research
A Morphologic and Immunohistochemical Comparison of Nuclear β-Catenin Expressing Testicular Sertoli Cell Tumors and Pancreatic Solid Pseudopapillary Neoplasms Supporting Their Continued Separate Classification
Some recent reports suggested that many Sertoli cell tumors, not otherwise specified (SCTs-NOS) of the testis were analogs of the solid pseudopapillary neoplasm (SPN) of the pancreas. One of the most relied on pieces of information for this assertion was the shared occurrence in both neoplasms of exon 3 mutations of the CTNNB1 gene, which was reflected by nuclear β-catenin expression. We, therefore, compared the morphologic and immunohistochemical features of 18 SCTs-NOS with strong, diffuse nuclear β-catenin expression with 16 SPNs that also showed such positivity. Although there were clear similarities in the light mic...
Source: The American Journal of Surgical Pathology - July 30, 2020 Category: Pathology Tags: Original Articles Source Type: research
Glucagon ‐like peptide‐1 receptor is expressed in human and rodent testis
ConclusionIn our findings, a careful evaluation of human testicular tissues and rodent testis revealed Leydig cells as a potential target for GLP ‐1. Collectively, an effect of GLP‐1R in Leydig cell function may be presumed although future studies are needed to ascertain the GLP‐1R’s role both in normal and tumor Leydig cells. (Source: Andrology)
Source: Andrology - July 23, 2020 Category: Urology & Nephrology Authors: R. Caltabiano,
D. Condorelli,
S. Panza,
C. Boitani,
N. Musso,
D. Je žek,
L. Memeo,
L. Colarossi,
V. Rago,
V. Mularoni,
S. Spadola,
R. Castiglione,
M. Santoro,
S. Aquila,
R. D’Agata Tags: ORIGINAL ARTICLE Source Type: research
Sex-Cord Tumor with Annular Tubules with Unusual Morphology in an Infant with Peutz-Jeghers Syndrome.
Conclusion: SCTAT can occur as young as six months of age in PJS, and may show histologic overlap with lipid-rich Sertoli cell tumors.
PMID: 32609034 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - July 2, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
NSE positive Sertoli cell tumor of the testis: case report and literature review
Publication date: August 2020Source: Pathology - Research and Practice, Volume 216, Issue 8Author(s): Gregor Mikuz (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - June 5, 2020 Category: Pathology Source Type: research
Sertoli Cell Tumors of the Testes: Systematic Literature Review and Meta-Analysis of Outcomes in 435 Patients.
CONCLUSION: Our findings suggest that few local recurrences result after TSS, and no adjuvant therapy can be regarded as a standard of care. Several risk factors are predictive of metastatic disease. Surgery leads to remission in metastatic disease, whereas systemic treatment alone does not result in long-term remission.
IMPLICATIONS FOR PRACTICE: Testicular Sertoli cell tumors usually present without metastatic disease and show low local recurrence rates after testis-sparing surgery; no adjuvant therapy option can be regarded as a standard of care. Patients with risk factors should undergo staging investigations. ...
Source: The Oncologist - February 10, 2020 Category: Cancer & Oncology Authors: Grogg J, Schneider K, Bode PK, Kranzbühler B, Eberli D, Sulser T, Lorch A, Beyer J, Hermanns T, Fankhauser CD Tags: Oncologist Source Type: research
