The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice.
Abstract
The self-renewal, proliferation, and differentiation of the spermatogonial populations must be finely coordinated in the mammalian testis, as dysregulation of these processes can lead to subfertility, infertility, or the formation of tumors. There are wide gaps in our understanding of how these spermatogonial populations are formed and maintained, and our laboratory has focused on identifying the molecular and cellular pathways that direct their development. Others and we have shown, using a combination of pharmacologic inhibitors and genetic models, that activation of mTOR complex 1 (mTORC1) is i...
Source: Biology of Reproduction - September 10, 2018 Category: Reproduction Medicine Authors: Serra N, Velte EK, Niedenberger BA, Kirsanov O, Geyer CB Tags: Biol Reprod Source Type: research
Mayer-Rokitansky-Küster-Hauser Syndrome With Bilateral Ovarian Sertoli Cell Tumors: Review of the Literature and Report of a Rare Case
Conclusions
The case presented is unique in that 2 rare pathologies, bilateral Sertoli cell tumors of the ovary and MRKH syndrome, developed concomitantly in the same patient. (Source: Journal of Pelvic Medicine and Surgery)
Source: Journal of Pelvic Medicine and Surgery - August 28, 2018 Category: Surgery Tags: Case Reports Source Type: research
Pseudo –“solid pseudopapillary neoplasms” of the testis: in reality Sertoli cell tumors
We read with interest and concern two reports published in Human Pathology [1,2] concerning testicular neoplasms that were felt to be “testicular analogues” of the well-known “solid pseudopapillary neoplasm” (SPN) of the pancreas, albeit in one of the 2 papers the authors preferred to designate the tumors as primary signet ring stromal tumors of the testis [1]. Although we acknowledge that the pseudopapillae in the SPNs ma y be limited in amount, their apparent absence, according to the descriptions of the microscopic findings in all of the 14 tumors in these 2 reports, struck us as unusual for a tumor the authors ...
Source: Human Pathology - August 12, 2018 Category: Pathology Authors: Thomas M. Ulbright, Robert H. Young Tags: Correspondence Source Type: research
Sertoli Cell Tumour and Uterine Leiomyoma in Miniature Schnauzer Dogs with Persistent Müllerian Duct Syndrome Caused by Mutation in the AMHR2 Gene
This report describes two miniature schnauzer dogs with PMDS caused by a known nonsense mutation in the AMHR2 gene, with concurrent development of genital neoplasia. The first case (78,XY and SRY-positive) had unilateral cryptorchidism and a Sertoli cell tumour in the abdominal testicle. The second case (mosaic karyotype 77,XY,rob/78,XY and SRY-positive) had both gonads descended in the scrotum and developed an abdominal mass derived from the uterine wall, which showed histological features typical of leiomyoma. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - July 10, 2018 Category: Pathology Source Type: research
Pazopanib treatment of a platinum-resistant recurrence of a high-grade Sertoli cell tumor and assessment of the treatment response by FDG-PET/CT: A case report
Publication date: May 2018Source: Gynecologic Oncology Reports, Volume 24Author(s): Kayo Inoue, Hiroshi Tsubamoto, Keiko Ishida-Nisigami, Yoshitaka Torii, Seiichi HirotaAbstractOvarian Sertoli cell tumors (SCTs) are rare sex cord tumors (Oliva et al., 2005). The standard treatment for high-grade SCTs is surgery followed by platinum-based chemotherapy. Although platinum-based chemotherapy is also an option for recurrent SCTs (Sigismondi et al., 2012), there is no established chemotherapy regimen for platinum-resistant recurrent SCTs. The effectiveness of pazopanib in treating epithelial ovarian cancer has recently been repo...
Source: Gynecologic Oncology Reports - July 10, 2018 Category: OBGYN Source Type: research
Sertoli Cell Tumour and Uterine Leiomyoma in Miniature Schnauzer Dogs with Persistent Müllerian Duct Syndrome Caused by Mutation in the AMHR2 Gene
This report describes two miniature schnauzer dogs with PMDS caused by a known nonsense mutation in the AMHR2 gene, with concurrent development of genital neoplasia. The first case (78,XY and SRY-positive) had unilateral cryptorchidism and a Sertoli cell tumour in the abdominal testicle. The second case (mosaic karyotype 77,XY,rob/78,XY and SRY-positive) had both gonads descended in the scrotum and developed an abdominal mass derived from the uterine wall, which showed histological features typical of leiomyoma. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research
Pazopanib treatment of a platinum-resistant recurrence of a high-grade Sertoli cell tumor and assessment of the treatment response by FDG-PET/CT: A case report
Publication date: May 2018Source: Gynecologic Oncology Reports, Volume 24Author(s): Kayo Inoue, Hiroshi Tsubamoto, Keiko Ishida-Nisigami, Yoshitaka Torii, Seiichi HirotaAbstractOvarian Sertoli cell tumors (SCTs) are rare sex cord tumors (Oliva et al., 2005). The standard treatment for high-grade SCTs is surgery followed by platinum-based chemotherapy. Although platinum-based chemotherapy is also an option for recurrent SCTs (Sigismondi et al., 2012), there is no established chemotherapy regimen for platinum-resistant recurrent SCTs. The effectiveness of pazopanib in treating epithelial ovarian cancer has recently been repo...
Source: Gynecologic Oncology Reports - July 5, 2018 Category: OBGYN Source Type: research
Recently Described and Clinically Important Entities in Testis Tumors.
CONCLUSIONS: - Most changes occurred in the germ cell tumor classification, including replacement of the terms intratubular germ cell neoplasia unclassified and carcinoma in situ by germ cell neoplasia in situ; subdivision of the tumors into 2 main categories, those derived from germ cell neoplasia in situ and those not derived from germ cell neoplasia in situ; distinction of germ cell neoplasia in situ from germ cells with delayed maturation and pre-germ cell neoplasia in situ; expansion of the trophoblastic tumor category to include epithelioid trophoblastic tumor and cystic trophoblastic tumor; and substitution of sperm...
Source: Archives of Pathology and Laboratory Medicine - June 27, 2018 Category: Laboratory Medicine Authors: Ulbright TM Tags: Arch Pathol Lab Med Source Type: research
Malignant Female Adnexal Tumor of Probable Wolffian Origin: Case Report and Literature Review
Although most female adnexal tumors of probable Wolffian origin have a benign biologic behavior, occasional cases have exhibited malignant potential. We encountered a 50-yr-old woman with an uncommon female adnexal tumors of probable Wolffian origin, which involved bilateral ovaries, invaded the ipsilateral fallopian tube, and extended to the uterine serosa. The initial histopathologic presentation caused significant confusion in pathologic diagnosis. Multiple differential diagnoses including ovarian endometrioid carcinoma, Sertoli cell tumor, and metastasis from nongynecologic organs were considered. After careful examina...
Source: International Journal of Gynecological Pathology - June 11, 2018 Category: Pathology Tags: Pathology of the Upper Genital Tract: Case Reports Source Type: research
Sertoli Cell Tumour and Uterine Leiomyoma in Miniature Schnauzer Dogs with Persistent M üllerian Duct Syndrome Caused by Mutation in the AMHR2 Gene
This report describes two miniature schnauzer dogs with PMDS caused by a known nonsense mutation in the AMHR2 gene, with concurrent development of genital neoplasia. The first case (78,XY and SRY-positive) had unilateral cryptorchidism and a Sertoli cell tumour in the abdominal testicle. The second case (mosaic karyotype 77,XY,rob/78,XY and SRY-positive) had both gonads descended in the scrotum and developed an abdominal mass derived from the uterine wall, which showed histological features typical of leiomyoma. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - June 1, 2018 Category: Pathology Source Type: research
Effects of saturated palmitic acid and omega-3 polyunsaturated fatty acids on Sertoli cell apoptosis.
Abstract
Obesity is believed to negatively affect male semen quality and is accompanied by dysregulation of free fatty acid (FFA) metabolism in plasma. However, the implication of dysregulated FFA on semen quality and the involvement of Sertoli cells remain unclear. In the present study, we report obesity decreased Sertoli cell viability through dysregulated FFAs. We observed an increased rate of apoptosis in Sertoli cells, accompanied with elevated FFA levels, in the testes of obese mice that were provided a high-fat diet (HFD). Moreover, the levels of reactive oxygen species were elevated. Furthermore, w...
Source: Systems Biology in Reproductive Medicine - May 25, 2018 Category: Reproduction Medicine Authors: Hu X, Ge X, Liang W, Shao Y, Jing J, Wang C, Zeng R, Yao B Tags: Syst Biol Reprod Med Source Type: research
A novel mouse model of testicular granulosa cell tumors
This study was performed using mice, and the direct relevance of the experimental paradigm and findings to human testicular GrCTs awaits further investigation. Of note, constitutive activation of TGFBR1 was employed to enhance TGFB/SMAD signaling activity and may not be interpreted as the genetic cause of the disease.WIDER IMPLICATIONS OF THE FINDINGSThis mouse model may prove to be a useful addition to the mouse genetics toolkit for GrCT research. Our finding that dysregulation of TGFB signaling results in the development of testicular GrCTs supports a common origin between Sertoli cells and granulosa cells, and highlight...
Source: Molecular Human Reproduction - May 21, 2018 Category: Molecular Biology Source Type: research
Prepubertal Malignant Large Cell Calcifying Sertoli Cell Tumor of the Testis
An otherwise healthy 7-year-old boy was diagnosed with malignant large cell calcifying Sertoli cell tumor (LCCSCT) of the testis. He underwent attempted left partial orchiectomy with conversion to radical orchiectomy due to concern for malignancy on intraoperative frozen section. There were no lymph node or visceral metastases. To our knowledge, this is the first report of malignant LCCSCT in the prepubertal population.Large cell calcifying Sertoli cell tumor (LCCSCT) of the testis is an extremely rare neoplasm, with low malignant potential. (Source: Urology)
Source: Urology - April 4, 2018 Category: Urology & Nephrology Authors: Guanqun Li, Matthew S. Lee, Kate H. Kraft, Amer Heider Tags: Pediatric Case Reports Source Type: research
Estrogen-induced myelotoxicity in a 4-year-old golden retriever dog due to a Sertoli cell tumor.
Abstract
A 4-year-old, unilateral cryptorchid golden retriever dog was presented to the Ontario Veterinary College Health Sciences Centre with gynecomastia, dribbling urine, lethargy, neutropenia, and thrombocytopenia. A Sertoli cell tumor was diagnosed in a cryptorchid testicle with estrogen-induced myelotoxicity. The tumor was removed and bone marrow regenerated within 4 months.
PMID: 29606731 [PubMed - in process] (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - April 1, 2018 Category: Veterinary Research Authors: Marshall H Tags: Can Vet J Source Type: research
