Direct evidence on the efficacy of GnRH agonist in recurrent steroid cell tumor-not otherwise specified
ConclusionSome ovarian SCT-NOS have GnRH receptors; thus, GnRHa may have a reducing effect for these tumors without major adverse event. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 17, 2019 Category: OBGYN Source Type: research

Isolated metastatic pancreatic adenocarcinoma to the uterine cervix: A case report
Publication date: Available online 4 July 2019Source: Gynecologic Oncology ReportsAuthor(s): Emily M. Hartsough, Britt K. Erickson, Anil Chauhan, Mahmoud A. KhalifaAbstractThe uterine cervix is an uncommon site of metastatic cancer. Specifically, pancreatic adenocarcinoma metastatic to the cervix is an exceptionally rarely reported phenomenon. We encountered a case of recurrent pancreatic adenocarcinoma presenting as a solitary metastasis to the cervix. To our knowledge, this is the only report describing an isolated recurrence of pancreatic adenocarcinoma to the cervix. When diagnosing metastatic disease to the cervix, it...
Source: Gynecologic Oncology Reports - July 5, 2019 Category: OBGYN Source Type: research

Effects of malaria/helminthic coinfections on cervical cancer progression among sub Saharan African women on HAART: A scoping review
The objective of this review is to assess whether concomitant infections with malaria and/or helminthic diseases have an impact on cervical disease progression in women on HAART.This scoping review was conducted in August 2018. To conduct this scoping review, we searched the relevant studies in electronic databases such as PUBMED, Global Health, EMBASE, CINAHL and SCOPUS published in the year between 1960 and 2018 using the following search terms HAART AND malaria OR Helminth and Female OR women.Eight studies qualified for this review. The literature underscores the need for women on HAART with multiple co-infections to us...
Source: Gynecologic Oncology Reports - July 5, 2019 Category: OBGYN Source Type: research

Afatinib use in recurrent epithelial ovarian carcinoma
Publication date: Available online 3 July 2019Source: Gynecologic Oncology ReportsAuthor(s): Amanda L. Shepherd-Littlejohn, Wyatt J. Hanft, Vanessa A. Kennedy, Edwin A. Alvarez (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 4, 2019 Category: OBGYN Source Type: research

Cervical cancer in Tanzania: A systematic review of current challenges in six domains
Publication date: August 2019Source: Gynecologic Oncology Reports, Volume 29Author(s): Ava S. Runge, Megan E. Bernstein, Alexa N. Lucas, Krishnansu S. TewariAbstractCervical cancer is the most common cancer in Tanzania. After excluding human immunodeficiency virus, lower respiratory infections, malaria, diarrheal diseases, and tuberculosis, cervical cancer kills more women than any other form of illness in the country. Unfortunately, Tanzania has a low doctor-to-patient ratio (1:50,000) and nearly 7000 women die each year from this disease. The clinical problem is further magnified by the country's lack of resources and pr...
Source: Gynecologic Oncology Reports - June 28, 2019 Category: OBGYN Source Type: research

An unusual case of uterine PEComa presenting with disseminated intravascular coagulation
Publication date: Available online 25 June 2019Source: Gynecologic Oncology ReportsAuthor(s): Rodger Rothenberger, Amanda Jackson, Ady Kendler, Thomas Herzog, Caroline BillingsleyAbstractPerivascular epithelioid cell neoplasms (PEComas) are mesenchymal neoplasms originating from the perivascular epithelioid cell (PEC) line. The World Health Organization (WHO) further defines PEComa as “a mesenchymal tumor composed of histologically and immunohistochemically distinctive perivascular epithelioid cells”. Gynecologic PEComas account for approximately ¼ of the PEComa cases reported in the literature and are h...
Source: Gynecologic Oncology Reports - June 26, 2019 Category: OBGYN Source Type: research

Cranial and intra-axial metastasis originating from a primary ovarian Dysgerminoma
Publication date: Available online 22 June 2019Source: Gynecologic Oncology ReportsAuthor(s): Tiffany L. Beck, Hitomi Momose, Jeffrey M. Dym, Vikas Y. Rao, Randy Bohart, Bram H. GoldsteinAbstractDysgerminomas are aggressive germ cell tumors that typically have a favorable prognosis, especially in patients diagnosed with early stage disease. We recount the history of a 23-year-old woman who was treated for a stage IA ovarian dysgerminoma in November 2017. Postoperatively, the patient was noncompliant insofar as obtaining routine lab evaluations; ten months later, she was diagnosed with a cranial metastasis that extended int...
Source: Gynecologic Oncology Reports - June 25, 2019 Category: OBGYN Source Type: research

Paraneoplastic Cushing's syndrome and hypercalcemia arising from metastatic endometrioid endometrial adenocarcinoma: A case report
Publication date: Available online 18 June 2019Source: Gynecologic Oncology ReportsAuthor(s): Evelyn Mitchell, Marcia Ciccone, Bing Zhang, Arnold Tsai, Laurie L. Brunette (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - June 19, 2019 Category: OBGYN Source Type: research

Checkpoint inhibitors in ovarian cancer: A review of preclinical data
Publication date: Available online 18 June 2019Source: Gynecologic Oncology ReportsAuthor(s): David W. Doo, Lyse A. Norian, Rebecca C. ArendAbstractOvarian cancer is the deadliest gynecologic malignancy, and relapse after initial treatment is frequently fatal. Although ovarian cancer typically has an immunosuppressive tumor microenvironment, a strong intratumoral T cell presence is associated with an improved response to chemotherapy and better overall prognosis. Given the success of checkpoint inhibitors in the treatment of other malignancies, there has been an attempt to replicate these results in ovarian cancer clinical...
Source: Gynecologic Oncology Reports - June 19, 2019 Category: OBGYN Source Type: research

Recurrence of vulvar carcinoma: A multidisciplinary approach
We present a video highlighting the crucial surgical steps of a successful pelvic exenterative procedure followed by perineal reconstruction with a muscle-sparing flap technique.A 72-year woman with history of stage II vulvar epidermoid carcinoma, treated with radical surgery and adjuvant radiotherapy. At two-year follow-up local recurrence was diagnosed, handled with large excisional surgical treatment. Within four years a second local recurrence occurred, with infiltrative and bulky dimensions extending to perianal region and vaginal wall.A multidisciplinary surgical approach with curative intent was performed, involving...
Source: Gynecologic Oncology Reports - June 19, 2019 Category: OBGYN Source Type: research

Blastic variant of plasma cell myeloma mimicking squamous cell carcinoma of the uterine cervix in a super-morbidly obese female
Publication date: Available online 14 June 2019Source: Gynecologic Oncology ReportsAuthor(s): Joan R. Tymon-Rosario, Yang Shi, Joseph DiVito, Sarp O. Aksel, Gregory M. Gressel (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - June 14, 2019 Category: OBGYN Source Type: research

Leptomeningeal spread of gestational trophoblastic neoplasia in a 19-year old woman
We report a case of a patient with gestational trophoblastic disease that metastasized to the lung and leptomeninges, who after treatment with induction chemotherapy using etoposide (E) and cisplatin (P) followed by etoposide, methotrexate and dactinomycin (EMA) chemotherapy achieved a complete response without brain radiation (Han et al., 2012). (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - June 13, 2019 Category: OBGYN Source Type: research

Type II endometrial cancers with minimal, non-invasive residual disease on final pathology: What should we do next?
This study examines a cohort of these patients and assesses outcomes including time to recurrence and risk of death after management with and without adjuvant therapies.Endometrial cancer patients with minimal or no remaining invasive disease on final pathologic specimen from 1995 to 2010 were included. Surgical procedure was at the discretion of the operating physician. Electronic medical records were used to abstract relevant clinicopathologic data and standard statistical methods were employed.70 patients met inclusion criteria, of which 26 were high grade histologies. Adjuvant therapies were given in 12 of 26 patients....
Source: Gynecologic Oncology Reports - May 25, 2019 Category: OBGYN Source Type: research

Cervical cancer in Tanzania a systematic review of current challenges in six domains
Publication date: Available online 21 May 2019Source: Gynecologic Oncology ReportsAuthor(s): Ava Runge, Megan Bernstein, Alexa Lucas, Krishnansu S. TewariAbstractCervical cancer is the most common cancer in Tanzania. After excluding human immunodeficiency virus, lower respiratory infections, malaria, diarrheal diseases, and tuberculosis, cervical cancer kills more women than any other form of illness in the country. Unfortunately, Tanzania has a low doctor-to-patient ratio (1:50,000) and nearly 7000 women die each year from this disease. The clinical problem is further magnified by the country's lack of resources and preva...
Source: Gynecologic Oncology Reports - May 22, 2019 Category: OBGYN Source Type: research

Dramatic response to Laetrile and cannabidiol (CBD) oil in a patient with metastatic low grade serous ovarian carcinoma
Publication date: Available online 17 May 2019Source: Gynecologic Oncology ReportsAuthor(s): Allison M. Barrie, Ariane C. Gushue, Ramez N. Eskander (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - May 19, 2019 Category: OBGYN Source Type: research

Paraneoplastic nodular regenerative hyperplasia of the liver associated with placental site trophoblastic tumor
Publication date: Available online 18 May 2019Source: Gynecologic Oncology ReportsAuthor(s): Kathryn Dumas, MaryAnn Wilbur, Jessica Dillon, William Cliby, Carrie Langstraat, Amanda N. Fader, Deyin Xing, Rebecca L. Stone (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - May 19, 2019 Category: OBGYN Source Type: research

Endometrial carcinoma in a 14-year-old: A case report
Publication date: Available online 16 May 2019Source: Gynecologic Oncology ReportsAuthor(s): Hajime Uda, Miho Kitai, Ai Kogiku, Anna Kobayashi, Toshiko Sakuma, Shoji Nagao, Satoshi Yamaguchi (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - May 17, 2019 Category: OBGYN Source Type: research

Post-radiation angiosarcoma of the uterine cervix
Publication date: Available online 14 May 2019Source: Gynecologic Oncology ReportsAuthor(s): Renée Betancourt, Cara Randall, Anna Kuan-Celarier, Lindsay West, John Soper, Christine Bookhout (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - May 16, 2019 Category: OBGYN Source Type: research

Editorial Board
Publication date: May 2019Source: Gynecologic Oncology Reports, Volume 28Author(s): (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - May 14, 2019 Category: OBGYN Source Type: research

Aortic abdominal dissection after retroperitoneal laparoscopic paraaortic lymphadenectomy
Publication date: Available online 9 May 2019Source: Gynecologic Oncology ReportsAuthor(s): Martina Aida Angeles, Olivier Meyrignac, Carlos Martínez-Gómez, Amel Daboussi, Jean Segal, Mathilde Del, Gwénaël Ferron, Alejandra Martinez (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - May 10, 2019 Category: OBGYN Source Type: research

Salvage treatment in recurrent endometrial cancer of the pelvis and peritoneal cavity
Publication date: Available online 10 May 2019Source: Gynecologic Oncology ReportsAuthor(s): Lindsey A. McAlarnen, Kelly Ryan, William Adams, Adam Gliniewicz, Abigail D. Winder, Margaret R. Liotta, Ronald K. Potkul, William Small, Matthew M. HarkenriderAbstractRegional recurrence of endometrial cancer is a challenging yet potentially curable group of patients without defined standard of care. Our aim is to determine optimal methods of salvage therapy for regionally recurrent endometrial cancer.Twenty-two cases of nodal, pelvic, or peritoneal cavity recurrences of endometrial cancer were identified from a single institution...
Source: Gynecologic Oncology Reports - May 10, 2019 Category: OBGYN Source Type: research

Molecular markers in uterine serous cancer: Correlation between endometrial biopsy and hysterectomy specimens
ConclusionsThe measurement of specific biomarkers correlated well between subjects' biopsy and hysterectomy specimens in women with USC as measured by a pathologist using routine clinical techniques. Preoperative diagnostic biopsy may be a useful tool for guiding neoadjuvant targeted therapy in USC. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - April 26, 2019 Category: OBGYN Source Type: research

NTRK-1 fusion in endocervical fibroblastic malignant peripheral nerve sheath tumor marking eligibility for larotrectinib therapy: A case report
Publication date: Available online 23 April 2019Source: Gynecologic Oncology ReportsAuthor(s): A.E. Wells, A.M. Mallen, M.M. Bui, D.R. Reed, S.M. Apte (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - April 24, 2019 Category: OBGYN Source Type: research

Do gynecologic oncology patients with severely diminished renal function and urinary tract obstruction benefit from a ureteral stent(s) or percutaneous nephrostomy tube(s)?
Publication date: Available online 24 April 2019Source: Gynecologic Oncology ReportsAuthor(s): Brooke Liang, Sara S. Lange, L. Stewart Massad, Rebecca Dick, Kathryn A. Mills, Andrea R. Hagemann, Carolyn K. McCourt, Premal H. Thaker, Katherine C. Fuh, David G. Mutch, Matthew A. Powell, Lindsay M. KurokiAbstractObjectiveTo assess the renal outcomes of gynecologic oncology patients who present with hydronephrosis and acute kidney injury (AKI), have
Source: Gynecologic Oncology Reports - April 24, 2019 Category: OBGYN Source Type: research

Role of adjuvant chemotherapy in the management of stage IC ovarian granulosa cell tumors
Publication date: Available online 17 April 2019Source: Gynecologic Oncology ReportsAuthor(s): Dimitrios Nasioudis, Emily M. Ko, Ashley F. Haggerty, Robert Giuntoli, Robert Burger, Mark A. Morgan, Nawar A. LatifAbstractObjectiveThe aim of the present study is to investigate the patterns of use and prognostic significance of adjuvant chemotherapy (CT) for patients with stage IC ovarian granulosa cell tumors (GCTs).MethodsWe identified patients with stage IC GCTs diagnosed between 2004 and 2015 in the National Cancer Data Base (NCDB). Logistic regression was performed to identify variables independently associated with chemo...
Source: Gynecologic Oncology Reports - April 18, 2019 Category: OBGYN Source Type: research

High grade sarcoma, with predominant neuroectodermal and minor embryonal rhabdomyosarcomatous tumor of the uterus: A case report
ConclusionTreatment of the predominant tumor, PNET, should be the primary goal of therapy. Vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide with tumor directed radiation may be efficacious for the treatment of this specific high grade uterine sarcoma. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - April 16, 2019 Category: OBGYN Source Type: research

A case of metastatic dysgerminoma treated with two cycles neoadjuvant chemotherapy followed by fertility-sparing minimally invasive surgery
Publication date: Available online 6 April 2019Source: Gynecologic Oncology ReportsAuthor(s): Katrin E. Eurich, Elizabeth Swisher, Mirna Toukatly, Lisa Koch, Emily S. Wu (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - April 8, 2019 Category: OBGYN Source Type: research

Retreatment with carboplatin and paclitaxel for recurrent endometrial cancer: A retrospective study of the Memorial Sloan Kettering Cancer Center experience
Publication date: Available online 5 April 2019Source: Gynecologic Oncology ReportsAuthor(s): Maria Rubinstein, Darragh Halpenny, Vicky Makker, Rachel N. Grisham, Carol Aghajanian, Karen CadooAbstractWomen with endometrial cancer (EC) frequently receive adjuvant paclitaxel and carboplatin (PC) chemotherapy. There is no standard first line chemotherapy at disease recurrence. Data extrapolated from ovarian cancer has suggested that patients with recurrent EC may benefit from further platinum-based chemotherapy. We performed a retrospective analysis of patients who were retreated with PC chemotherapy for recurrent EC at Memor...
Source: Gynecologic Oncology Reports - April 5, 2019 Category: OBGYN Source Type: research

Intestinal-type adenocarcinoma of the vulva: A case study
Publication date: Available online 29 March 2019Source: Gynecologic Oncology ReportsAuthor(s): Brian Kaltenecker, Robert Manos, Meagan McCall, Paul SparzakAbstractApproximately 5% of all gynecologic cancers are of the vulva, of which 90% are squamous cell in origin. Adenocarcinomas of the vulva are extremely infrequent with most relating to epithelial glands in the vulvar region. A 53 year old African American female presented to the emergency department complaining of a lesion on her left labia that had been present for the past 6 months. In the operating room, multiple biopsies were taken of the left labial lesion as...
Source: Gynecologic Oncology Reports - March 31, 2019 Category: OBGYN Source Type: research

A case of incidental endometrial adenocarcinoma diagnosed in early pregnancy and managed conservatively
We report a 29-year old nulliparous woman diagnosed with a grade 1 endometrioid adenocarcinoma of the endometrium arising from an atypical polypoid adenomyoma, while being investigated for a suspected threatened miscarriage at 7 weeks gestation. She presented complaining of vaginal bleeding and a small amount of soft tissue in the cervical os was found and sent for histology. An ultrasound scan was performed, which confirmed an intrauterine ongoing pregnancy. The patient had no further episodes of unscheduled bleeding. After the confirmed histological diagnosis an MRI scan was requested, and there were no evidence of myo...
Source: Gynecologic Oncology Reports - March 28, 2019 Category: OBGYN Source Type: research

Pancreaticobiliary metastasis presenting as primary mucinous ovarian neoplasm: A systematic literature review
Publication date: Available online 27 March 2019Source: Gynecologic Oncology ReportsAuthor(s): Sarah A. Ackroyd, Lauren Goetsch, Jennifer Brown, Karen Houck, Congli Wang, Enrique HernandezAbstractTrue primary mucinous ovarian carcinomas are rarer than originally thought and their clinical behavior and treatment response are different than more common epithelial ovarian carcinomas. Secondary ovarian neoplasms often mimic the clinical and histological features of mucinous ovarian cancer making their diagnosis, and therefore treatment, more difficult. Misdiagnosis can have a significant impact on both treatment and prognosis....
Source: Gynecologic Oncology Reports - March 28, 2019 Category: OBGYN Source Type: research

Co-occurring substance use disorder: The impact on treatment adherence in women with locally advanced cervical cancer
Publication date: Available online 27 March 2019Source: Gynecologic Oncology ReportsAuthor(s): Lisa A. Rubinsak, Mishka Terplan, Caitlin E. Martin, Emma C. Fields, William P. McGuire, Sarah M. TemkinAbstractThe purpose of this study was to identify the prevalence of substance use disorder and its association with adherence to treatment and survival in locally advanced cervical cancer patients treated with primary radiation therapy. This is a retrospective case series of locally advanced cervical cancer patients with substance use disorder in a single academic institution treated with radiation therapy between 2005 and 2016...
Source: Gynecologic Oncology Reports - March 28, 2019 Category: OBGYN Source Type: research

Heterotopic atypical trophoblasts mimicking ectopic choriocarcinoma coexistent with a viable intrauterine pregnancy: A diagnostic dilemma
Publication date: Available online 26 March 2019Source: Gynecologic Oncology ReportsAuthor(s): Varvara Mazina, Christopher Morse, Rouba Hadi, Heidi Gray (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - March 28, 2019 Category: OBGYN Source Type: research

Letter to the editor, Reply to: Cecile Colpaert et al.: Ultrastaging of sentinel lymph nodes in gynecological cancer: Repeating the story of breast cancer?
Publication date: Available online 26 March 2019Source: Gynecologic Oncology ReportsAuthor(s): David Cibula, W. Glenn McCluggage (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - March 28, 2019 Category: OBGYN Source Type: research

Laparoscopic diverting loop ileostomy for spontaneous colon perforation in advanced ovarian cancer
ConclusionBowel perforation in the elderly, presenting with cachexia and treatment-induced pancytopenia for advanced ovarian cancer, is often a harbinger of early death. Selected patients may benefit from a minimally invasive approach by an experienced gynecologic oncologist instead of vertical laparotomy, abdominal washout, diversion and the potential sequelae of an open abdomen. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - March 23, 2019 Category: OBGYN Source Type: research

The perceptions of gynecologic oncology fellows on readiness for subspecialty training following OB/GYNRESIDENCY
The objective of this study was to evaluate the perceptions of current and former fellows in gynecologic oncology of their readiness for fellowship training. A previously used survey was modified and distributed in 2016 to current and former fellows in GO. The survey explored domains of independent practice, psychomotor ability, clinical evaluation and scholarship. A standard Likert scale was employed and domains/responses were tailored to the subspecialty. A total of 150 current and recently former fellows responded to the survey, for a response rate of 38.7%. Nearly 70% of respondents reported being able to independently...
Source: Gynecologic Oncology Reports - March 23, 2019 Category: OBGYN Source Type: research

A rare case of Merkel cell carcinoma with ovarian metastasis
We describe a case of an 80-year-old woman with ovarian metastasis of MCC six years after excision of a cutaneous MCC on the cheek.DiscussionTo our knowledge only three cases with ovarian metastasis of MCC have been described so far. Our case is the second with distant metastasis to the ovary spreading from a primary tumor in the skin of the head, in the other two cases the primary tumor was in the inguinal skin.ConculsionMCC is a highly aggressive cutaneous and mucosal malignancy with frequent recurrence, lymph node and distant metastases. There is no clear consensus how to treat metastatic disease. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - March 20, 2019 Category: OBGYN Source Type: research

Clinical presentation of brain metastases from endometrial carcinoma: A case series
In conclusion, clinical presentation at time of diagnosis of brain metastases consistently includes neurologic signs and symptoms with persistent headache being the most common. Endometrial cancer patients that present with new neurologic complaints or exam findings should be evaluated for brain metastases. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - March 20, 2019 Category: OBGYN Source Type: research

Co-occurrence of Mayer-Rokitansky-Küster-Hauser syndrome and ovarian cancer: A case report and review of the literature
Publication date: Available online 17 March 2019Source: Gynecologic Oncology ReportsAuthor(s): Roberta Villa, Jacopo Azzollini, Bernard Peissel, Siranoush ManoukianAbstractBackgroundMayer-Rokitansky-Kuster-Hauser syndrome (MRKHS) is a congenital disorder of yet unknown etiology, characterized by agenesis/hypoplasia of the müllerian duct system. The occurrence of ovarian cancer (OC) in MRKHS is rare, with
Source: Gynecologic Oncology Reports - March 18, 2019 Category: OBGYN Source Type: research

Cervical cancer treatment in Haiti: A vertically-integrated model for low-resource settings
Publication date: Available online 16 March 2019Source: Gynecologic Oncology ReportsAuthor(s): Vincent DeGennaro, Madelyn Shafer, Meagan Kelly, Jean Ronald Cornely, Joseph Bernard (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - March 16, 2019 Category: OBGYN Source Type: research

Large cell neuroendocrine carcinoma of the endometrium: a report and review of the literature
Publication date: Available online 13 March 2019Source: Gynecologic Oncology ReportsAuthor(s): Courtney Jenny, Kristopher Kimball, Larry Kilgore, Jonathan BooneAbstractLarge-cell neuroendocrine tumor of the endometrium is a rare tumor type which is difficult to diagnose. Our routine tissue sampling is often non-productive and these tumors can be mistaken for other poorly differentiated carcinomas. Sites of metastatic disease sometimes confuse the identification of the primary organ, and histological diagnosis requires a choice of neuroendocrine biomarkers. In addition, there are no published diagnostic criteria for LCNEC o...
Source: Gynecologic Oncology Reports - March 14, 2019 Category: OBGYN Source Type: research

Isolated distant lymph node metastases in ovarian cancer. Should a new substage be created?
Publication date: Available online 13 March 2019Source: Gynecologic Oncology ReportsAuthor(s): Dimitrios Nasioudis, Emily M. Ko, Ashley F. Haggerty, Robert L. Giuntoli, Robert A. Burger, Mark A. Morgan, Nawar A. LatifAbstactObjectiveTo evaluate the prognostic significance of isolated distant lymph node metastases in comparison to other metastatic sites and stage IIIC disease.MethodsThe National Cancer Data Base was accessed and patients diagnosed between 2004 and 2014 with stage IV or IIIC epithelial ovarian cancer who met criteria for pathological staging were identified. Overall survival (OS) was calculated with Kaplan-M...
Source: Gynecologic Oncology Reports - March 14, 2019 Category: OBGYN Source Type: research

Less radical surgery for women with early stage cervical cancer: Our experience on radical vaginal trachelectomy and laparoscopic pelvic lymphadenectomy
We report the use of radical vaginal trachelectomy (RVT) with pelvic laparoscopic lymphadenectomy (LPL) in patients with early stages cervical cancer (FIGO stage IA2-IB1). This is a case series prospectively collected over a 6-year period (2011–2017) at the Ipswich hospital, UK. Cases were compared to a group of women with a similar stage of cervical cancer, but treated with radical hysterectomy (RH) and pelvic lymphadenectomy (PL). A total of 19 patients (group 1) underwent RVT and LPL, and 51 (group 2) had RH and PL. We included: 5/19 (26%) stage IA2 and 14/19 (74%) stage IB1. Among those, we had: 12/19 (63%) cases...
Source: Gynecologic Oncology Reports - March 13, 2019 Category: OBGYN Source Type: research

Complete surgical resection of isolated recurrent high-grade epithelial ovarian cancer in highly selected patients without chemotherapy is associated with an excellent outcome
This study finds that it may be reasonable to omit chemotherapy in highly selected patients after complete secondary surgical resection. Resection of isolated recurrences can be accomplished with minimally invasive surgery, and these patients have an excellent prognosis. Non-peritoneal recurrences may have a better prognosis after secondary surgery. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - March 8, 2019 Category: OBGYN Source Type: research

The volume of acute normovolemic hemodilution
Publication date: Available online 6 March 2019Source: Gynecologic Oncology ReportsAuthor(s): Junichi Saito, Kazuyoshi Hirota (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - March 6, 2019 Category: OBGYN Source Type: research

Multiple recurrences from cervical cancer presenting as skin metastasis of different morphologies
Publication date: Available online 28 February 2019Source: Gynecologic Oncology ReportsAuthor(s): Vatsala Katiyar, Tiago Araujo, Nasma Majeed, Nicholas Ree, Shweta GuptaAbstractSkin metastasis is an infrequent manifestation in oncology, with reported incidence of about 1.3% in cervical cancer. When present, it usually signals advanced disease with very limited, mostly palliative treatment options. Here we present a patient who was diagnosed with cervical cancer at an early stage and later recurred twice with skin lesions of different morphologies. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - March 1, 2019 Category: OBGYN Source Type: research

Endometrial cancer arising after complete remission of uterine malignant lymphoma: A case report and mutation analysis
Publication date: Available online 27 February 2019Source: Gynecologic Oncology ReportsAuthor(s): Ikumi Kuno, Hiroshi Yoshida, Takashi Kohno, Atsushi Ochiai, Tomoyasu KatoAbstractUterine malignant lymphoma is rare and its association with secondary cancer has not been fully described. Here, we report a rare case of endometrial cancer arising after 1 year of complete remission of uterine diffuse large B-cell lymphoma (DLBCL). An 88-year-old woman was referred to us for abnormal genital bleeding and was diagnosed with uterine DLBCL. She underwent chemotherapy comprising rituximab with cyclophosphamide, doxorubicin, vincris...
Source: Gynecologic Oncology Reports - February 27, 2019 Category: OBGYN Source Type: research

Identification of a therapeutic target using molecular sequencing for treatment of recurrent uterine serous adenocarcinoma
We report a case of a 68-year old woman with recurrent uterine serous adenocarcinoma who underwent molecular testing and genetic sequencing of her tumor. She was found to have focal amplification of ERBB2 confirmed by amplification and overexpression of HER2/neu via fluorescence in situ hybridization and immunohistochemistry. Given the identification of this potential target and progression of disease, trastuzumab was added to the patient's chemotherapy regimen with ultimate complete response. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - February 22, 2019 Category: OBGYN Source Type: research

Long term control of luteinized thecoma with sclerosing peritonitis with leuprorelin and tamoxifen treatment
ConclusionEven in the absence of solid evidence, the combination of leuprorelin and tamoxifen could be considered as a possible medical treatment of LTSP. Considering the limitations related to the rarity of disease, further studies are needed to improve its management. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - February 17, 2019 Category: OBGYN Source Type: research

The dilemma of early preventive oophorectomy in familial small cell carcinoma of the ovary of hypercalcemic type
Publication date: Available online 17 February 2019Source: Gynecologic Oncology ReportsAuthor(s): Tanja Pejovic, W. Glenn McCluggage, Adam J. Krieg, Fuhua Xu, David M. Lee, Leora Witkowski, William D. Foulkes (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - February 17, 2019 Category: OBGYN Source Type: research