Pazopanib treatment of a platinum-resistant recurrence of a high-grade Sertoli cell tumor and assessment of the treatment response by FDG-PET/CT: A case report
Publication date: Available online 11 March 2018 Source:Gynecologic Oncology Reports Author(s): Hiroshi Tsubamoto, Keiko Ishida-Nisigami, Yoshitaka Torii, Seiichi Hirota, Kayo Inoue Ovarian Sertoli cell tumors (SCTs) are rare sex cord tumors (Oliva et al., 2005). The standard treatment for high-grade SCTs is surgery followed by platinum-based chemotherapy. Although platinum-based chemotherapy is also an option for recurrent SCTs (Sigismondi et al., 2012), there is no established chemotherapy regimen for platinum-resistant recurrent SCTs. The effectiveness of pazopanib in treating epithelial ovarian cancer has recent...
Source: Gynecologic Oncology Reports - March 11, 2018 Category: OBGYN Source Type: research
Treatment of CD30‐Expressing Germ Cell Tumors and Sex Cord Stromal Tumors with Brentuximab Vedotin: Identification and Report of Seven Cases
Conclusion.Treatment of relapsed or refractory germ cell tumors with brentuximab vedotin can induce durable responses with a manageable toxicity profile.Implications for Practice.This case series of seven patients with relapsed or refractory CD30‐expressing germ cell tumors (GCTs) or sex cord stromal tumors demonstrates that brentuximab vedotin has activity against GCTs and is well tolerated in heavily pretreated patients with these aggressive tumor types. One patient achieved a complete response that has been durable for almost 4 years since the discontinuation of treatment with brentuximab vedotin. Therefore, brentuxim...
Source: The Oncologist - March 9, 2018 Category: Cancer & Oncology Authors: Costantine Albany, Lawrence Einhorn, Lawrence Garbo, Thomas Boyd, Neil Josephson, Darren R. Feldman Tags: Genitourinary Cancer Source Type: research
Differential expression profiles of conserved Snail transcription factors in the mouse testis
Summary
Snail transcription factors are key regulators of cellular transitions during embryonic development and tumorigenesis. The closely related SNAI1 and SNAI2 proteins induce epithelial–mesenchymal transitions (EMTs), acting predominantly as transcriptional repressors, while the functions of SNAI3 are unknown. An initial examination of Snai2‐deficient mice provided evidence of deficient spermatogenesis. To address the hypothesis that Snail proteins are important for male fertility, this study provides the first comprehensive cellular expression profiles of all three mammalian Snail genes in the post‐natal mouse t...
Source: Andrology - January 1, 2018 Category: Urology & Nephrology Authors: D. J. Micati, G. R. Hime, E. A. McLaughlin, H. E. Abud, K. L. Loveland Tags: Original Article Source Type: research
Treatment of CD30-Expressing Germ Cell Tumors and Sex Cord Stromal Tumors with Brentuximab Vedotin: Identification and Report of Seven Cases.
CONCLUSION: Treatment of relapsed or refractory germ cell tumors with brentuximab vedotin can induce durable responses with a manageable toxicity profile.
IMPLICATIONS FOR PRACTICE: This case series of seven patients with relapsed or refractory CD30-expressing germ cell tumors (GCTs) or sex cord stromal tumors demonstrates that brentuximab vedotin has activity against GCTs and is well tolerated in heavily pretreated patients with these aggressive tumor types. One patient achieved a complete response that has been durable for almost 4 years since the discontinuation of treatment with brentuximab vedotin. Therefore, ...
Source: The Oncologist - December 8, 2017 Category: Cancer & Oncology Authors: Albany C, Einhorn L, Garbo L, Boyd T, Josephson N, Feldman DR Tags: Oncologist Source Type: research
Incidentally detected testicular lesions < 10 mm in diameter: can orchidectomy be avoided?
ConclusionThe majority of testicular lesions <10 mm, identified by radiology, are benign, although around one third are malignant. At <5 mm, in this study 100% of lesions were benign. Tumour markers appear unhelpful in the distinction of these small tumours. We suggest that regular ultrasound surveillance ought to be more widely used for testicular lesions of this size. Testicular tumours now have a very high cure rate and changes in size of lesions may be monitored prospectively with minimal risk of increased morbidity. Patients who undergo an orchidectomy for lesions <5 mm are “Victims of Modern Imaging Techno...
Source: BJU International - October 15, 2017 Category: Urology & Nephrology Authors: Glenda Scandura, Clare Verrill, Andrew Protheroe, Johnson Joseph, Wendy Ansell, Anju Sahdev, Jonathan Shamash, Daniel M Berney Tags: Original Article Source Type: research
Microscopic tubal sex ‐cord proliferations with a Sertoli cell tumour pattern and ovarian‐type stromal transformation of the fimbriae
(Source: Histopathology)
Source: Histopathology - September 22, 2017 Category: Pathology Authors: Vicente Crespo ‐Lora, Nelly Cruz‐Viruel, Margherita Goia, Silvia Chiarelli, Francisco F Nogales Tags: Correspondence Source Type: research
Unusual presentations of Carney Complex in patient with a novel PRKAR1A mutation.
Authors: Akin S, Noyan S, Dagdelen S, Pasaoglu I, Kaynaroglu V, Askun MM, Bilen CY, Kiratli H, Baydar DE, Onder S, Sokmensuer C, Aytemir K, Erkin G, Kiratli PO, Alikasifoglu M, Erbas T
Abstract
Carney Complex (CNC) is a multiple neoplasia syndrome characterized by skin tumors and pigmented lesions, myxomas, and various endocrine tumors. The aim of this case report was to describe a case of CNC with a novel PRKAR1A mutation. A man aged 46 years with a medical history of surgery for cardiac myxomas at the age of 39 was admitted to our hospital because of four newly-developed heart masses. The histologic exam...
Source: Neuroendocrinology Letters - September 7, 2017 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
Expression patterns of HENMT1 and PIWIL1 in human testis: implications for transposon expression
This study aimed to define the expression patterns of HENMT1 and PIWI proteins in human testis and investigate their association with transposon expression, infertility sub-type or development of testicular germ cell tumours (TGCTs). Testis biopsies showing normal spermatogenesis were used to identify normal localisation patterns of HENMT1 and PIWIL1 by immunolocalisation and RT-PCR after laser microdissection. 222 testis biopsies representing normal spermatogenesis, hypospermatogenesis, spermatogenic arrests, Sertoli cell-only (SCO) tumours and TGCTs were analysed by RT-qPCR for expression of HENMT1/PIWIL1/PIWIL2/PIWIL3/P...
Source: Reproduction - September 6, 2017 Category: Reproduction Medicine Authors: Hempfling, A. L., Lim, S. L., Adelson, D. L., Evans, J., OConnor, A. E., Qu, Z. P., Kliesch, S., Weidner, W., OBryan, M. K., Bergmann, M. Tags: Research Source Type: research
Immunophenotypic Comparison of Testicular Sclerosing Sertoli Cell Tumors and Sertoli Cell Tumors Not Otherwise Specified
Testicular Sertoli cell tumors (SCT) are rare and most fall into the category of SCT-not otherwise specified (SCT-NOS). Only a few additional types of SCT are recognized. Sclerosing SCT (S-SCT), originally described in 1991, comprises a small fraction of SCTs and was considered a specific entity until the 2016 revision of the World Health Organization classification of non-germ cell tumors, where it was classified as a morphologic variant of SCT-NOS. In a recent study, differences in expression of PAX2/PAX8, inhibin, androgen receptor and S100 protein between SCT-NOS and S-SCT were noted in a small number of cases. (Source: Human Pathology)
Source: Human Pathology - September 2, 2017 Category: Pathology Authors: Hector Mesa, Chen Zhang, Juan C. Manivel, Thomas M. Ulbright Tags: Original contribution Source Type: research
Microscopic tubal sex cord proliferations with a Sertoli cell tumour pattern and ovarian ‐type stromal transformation of the fimbriae
This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - July 30, 2017 Category: Pathology Authors: Vicente Crespo ‐Lora, Nelly Cruz‐Viruel, Margherita Goia, Silvia Chiarelli, Francisco F Nogales Tags: Correspondence Source Type: research
Anti-Mullerian Hormone (AMH) Determinations in the Pediatric and Adolescent Endocrine Practice.
Authors: Weintraub A, Eldar-Geva T
Abstract
Anti-Mullerian hormone (AMH), secreted by immature testicular Sertoli-cells, triggers the regression of male fetal Mullerian ducts. During puberty, AMH is downregulated by intratesticular testosterone. In females, AMH is secreted from granulosa cells of immature ovarian follicles from late prenatal life until menopause; serum concentration is 5-20 times lower in females than in males through lifetime. In boys, AMH determination is useful in the clinical setting as a marker of Sertoli cell function. Serum AMH is low in infants with hypogonadotrophic hypogonadism (...
Source: Pediatric Endocrinology Reviews - June 16, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Benign Large Cell Calcifying Sertoli Tumor of the Testis in a 13 Year Old Male Treated with Partial Orchiectomy
Large cell calcifying Sertoli cell tumors of the testis (LCCSCT) is an exceptionally rare lesion, found sparsely in any medical literature. There is a correlation between this entity and Peutz −Jeghers syndrome and Carney's complex (40% of tumors). The remaining 60% of tumors are sporadic.A 13 year old male underwent a left partial orchiectomy. Intra-op frozen section was used. Pathology revealed a benign large cell calcifying sertoli cell tumor with negative margins. To our knowledge t here is not a case in the literature of a LCCSCT being treated with partial orchiectomy in a pubertal male with a normal contralateral t...
Source: Urology - May 24, 2017 Category: Urology & Nephrology Authors: Anthony J. Tracey, Wolfgang H. Cerwinka Tags: Pediatric Case Reports Source Type: research
Benign Large-cell Calcifying Sertoli Tumor of the Testis in a 13-Year-Old Male Patient Treated With Partial Orchiectomy
Large-cell calcifying Sertoli cell tumor (LCCSCT) of the testis is an exceptionally rare lesion, found sparsely in any medical literature. There is a correlation between this entity and Peutz-Jeghers syndrome and Carney complex (40% of tumors). The remaining 60% of tumors are sporadic. A 13-year-old male patient underwent a left partial orchiectomy. Intraoperative frozen section was used, and pathology revealed a benign LCCSCT with negative margins. To our knowledge, there is not a case in the literature of an LCCSCT being treated with partial orchiectomy in a pubertal male with a normal contralateral testis. (Source: Urology)
Source: Urology - May 24, 2017 Category: Urology & Nephrology Authors: Anthony J. Tracey, Wolfgang H. Cerwinka Tags: Pediatric Case Reports Source Type: research
A Hard Ball for a Tennis Player: A Rare Case of Large Calcifying Sertoli Cell Testicular Tumor
Publication date: July 2017 Source:Urology Case Reports, Volume 13 Author(s): Simone Albisinni, Ibrahim Biaou, Fouad Aoun, Romain Diamand, Ksenija Limani, Alexandre Peltier, Roland van Velthoven, Eric Hawaux A 46 year old tennis player was addressed to our clinic after incidental finding of right testicular calcification on plain x-ray of the spine. Urologic consultation revealed a hard non-tender testicular mass which required inguinal orchiectomy. Final histology revealed large cell calcifying Sertoli cell tumor: we herein present the case and review current physiopathology of such rare testicular disease. (Sou...
Source: Urology Case Reports - May 10, 2017 Category: Urology & Nephrology Source Type: research
Y-Chromosomal Microdeletion in Idiopathic Azoospermic and Severe Oligozoospermic Indonesian Men.
CONCLUSION: the frequency of partial deletion of AZFa was found to be relatively high in our center. The type of deletion is associated with the testicular histology.
PMID: 28450650 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - May 1, 2017 Category: Internal Medicine Tags: Acta Med Indones Source Type: research
