Fructose-1,6-bisphosphatase deficiency presented with complex febrile convulsion.
Authors: Abstract Fructose-1,6-bisphosphatase (FBPase) deficiency is a rare inborn error of metabolism affecting gluconeogenesis caused by FBP1 gene mutations. It could be more fatal to infants and children when glycogen reserves are insufficient. A 4-year-old girl was admitted with complex febrile convulsion. Initial laboratory results showed hypoglycemia, metabolic acidosis, and hyperlactatemia. Plasma amino acid and urine organic acid analyses showed increased levels of alanine and tricarboxylic acid cycle intermediates. However, she had similar clinical features, including confusion under severe hypoglyce...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Therapy for Gastroenteropancreatic Neuroendocrine Tumors: drug evaluation reports review in Spain.
CONCLUSIONS: Everolimus and sunitinib are new drugs available for the treatment of GEP NET patients reported to have promising effects in advanced diseases. However, the reports are limited and thus new clinical studies on the impact of these drugs on clinical outcome, prognosis, financial burden and feasibility are necessary to support further recommendations. PMID: 30927758 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Etiology, Risk Factors and Outcome of 1003 Cases of Infective Endocarditis from a 33-year National Survey in the Slovak Republic: An increasing proportion of elderly patients.
Authors: Abstract BACKGROUND: Infective endocarditis (IE) is still a significant cause of mortality in European hospitals, despite of the fact, that large nationwide studies were performed in last twenty years and pathogens are well known. The aim of the study was to assess risk factors, mortality, etiology and proportion of elderly patients within a longitudinal nation wide survey of infectious endocarditis in Slovakia. PATIENTS AND METHODS: Etiology, risk factors and outcome of 1003 cases of infective endocarditis (IE) in Slovakia over the last 33 years have been assessed. RESULTS: The majority of IE wer...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The influence of electromagnetic fields generated by wireless connectivity systems on the occurrence of emotional disorders in women: A preliminary report.
CONCLUSIONS: The study showed that exposure to electromagnetic fields from GSM 900 and 1800 generated by base stations contributed to the occurrence of depressive disorders among medical personnel, while exposure to WLAN EMF had the opposite effect. Spending time on phone conversations decreased the feeling of depression and increased trait anxiety in medical staff. Spending free time on physical activity intensified depressive states in women working in trade. Further studies on the influence of low-frequency EMFs on the human nervous system are needed. PMID: 30927760 [PubMed - as supplied by publisher] (Source: Neuro...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Thioredoxin is a potential therapy for light-induced photoreceptor degeneration in diabetic mice.
Authors: Abstract BACKGROUND: Retina degeneration is a set of disease that can be characterized by progressive loss of rod or cone photoreceptors that can experience higher light exposure compared with other parts of our body. MATERIAL AND METHODS: To investigate in diabetic mice the effects of different light on retinal photoreceptor and its related mechanisms, 4-6 weeks male Balb/c mices were randomly divided into control group, light treatment group (light 1 and light 2), light treatment with filter membrane group (LFM1 and LFM2), light treatment filter blue light group (LFB), diabetic group (DM), diabetic ...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Tissue metallothionein response in the Japanese quail associated with exposure to cyanobacterial biomass, lead and the Newcastle disease virus.
Authors: Abstract OBJECTIVES: Here we tested the hypothesis that multiple toxic and infectious stressors combine in their adverse effects to produce higher tissue responses of metallothioneins (MTs) in birds. METHODS: We used Japanese quails as a model avian species. The study is based on data obtained from single and combined exposures of Japanese quails to cyanobacterial biomass containing microcystins, lead and a live Newcastle disease vaccination virus. Eight groups of 5 birds were exposed to single, double and triple combinations of these stressors and compared with controls. Birds were euthanized after t...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The association of serum lipid level with ischemic stroke in the elderly of Xinjiang.
Authors: Abstract BACKGROUND: The aim of the present study is to determine the association of serum lipid level in the above 55-year-old age elderly with ischemic stroke (IS) in Xinjiang regions, China. METHODS: 408 patients with IS and 347 healthy individuals as control in the ≥55-year-old elderly were selected for the present study in Xinjiang province of China from July 2010 to July 2012. Patients were divided into different groups according to the IS subtypes (large-artery atherosclerosis, LAA; cardio-aortic embolism CE; small-artery occlusion, SAO), plague stability, hypertension and diabetes. The seru...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Angiotensinogen gene T174M polymorphism is related to Hashimoto's thyroiditis.
Authors: Abstract OBJECTIVES: The Hashimoto thyroiditis is found to be Th1-related autoimmunity. Recently, it has been proved that the renin-angiotensin-aldosterone system (RAAS) may be involved in promoting Th1-mediated autoimmune diseases. However, the role of RAAS in HT pathogenesis remains still unknown. The aim of this study was to determine whether the polymorphisms of ACE, AGTR1 and AGT genes are associated with HT. MATERIAL AND METHODS: Polymerase Chain Reaction (PCR) was performed to determine ACE I/D, AGTR1 A1166C and AGT T174M polymorphisms and next chi-square test was used to compare allele frequen...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Selected Risk Factors of Falls in Hospitalized Patients: A Case-Control Study.
CONCLUSION: Interventions aimed at prevention of falls should be included in care plans, especially for older patients, patients who have fallen in the past, patients who have movement restriction, patients with cognitive dysfunction, and patients with increased need of assistance with basic daily activities. PMID: 30860679 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 14, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Clinical characteristics of subacute thyroiditis is different than it used to be - current state based on 15 years own material.
CONCLUSION: In our study, several new features of current SAT course, different from what we used to know about the disease, were reported. Higher frequency of painless SAT than it was ever described, was observed. Moreover, in as much as one third of the patients aTPO and/or aTg were present, and in 6% of SAT cases the coexistence of TRAb was demonstrated. Transient microhaematuria was typical for the acute SAT phase. PMID: 30860680 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 14, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Tapentadol in an Experimental Animal Model of Acute Orofacial Pain.
Authors: Abstract OBJECTIVE: Tapentadol exhibits a synergistic dual effect effect (MOR / NRI) -agonist effect on noradrena-line reuptake inhibition (NRI). Tapentadol is effective on pain with neuropathic characteristics, therefore we decided to use it in an experimental model of acute orofacial pain. METHODS: The Orofacial Stimulation Test, developed by Ugo Basile, measures hypersensitivity to thermal or mechanical stimulation of the trigeminal area. In the experiment, rats had to voluntarily contact a thermal or mechanical stimulator with their unshaved vibrissal pad in order to access a food reward. Twenty a...
Source: Neuroendocrinology Letters - March 14, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Potential of the multivitamin-mineral-trace element composition LaVita ® before, during and after pregnancy.
CONCLUSION: The regular intake filled up the respective storage compartments and reservoirs in the tissues, and improved the metabolic status. Female participants tended to benefit more than male. We conclude that the composition is safe, and warrants optimized micronutrient supply during pregnancy or postnatal breastfeeding. PMID: 30860682 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 14, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro.
CONCLUSION: The results found demonstrate that TKIs vandetanib, lenvatinib and cabozantinib cause a decrease in oxidative activation of DNA-damaging drug ellipticine by several CYP enzymes in vitro which might lead to a decrease in its pharmacological efficiency. In contrast, they practically do not influence its detoxification catalyzed by CYP1A1, 1A2 and peroxidases. The present study indicates that tested TKIs seem not to have a potency to increase ellipticine anticancer efficiency. PMID: 30860683 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 14, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Effects of peripheral administration of GH and IGF-I on gene expression in the hippocampus of hypophysectomised rats.
CONCLUSION: The 19-day GH-infusion induced similar effects as those reported after 6-day GH treatment, with the addition of the regulation of transcript Alox15. IGF-I induced altered gene expression in relation to its effect on weight gain. This study underlines that there is an entity of transcripts involved in neuroprotection and vascular tone that is regulated by both systemic GH and IGF-I. For other transcripts, the longer duration of this study did not significantly enhance the marginal effects of GH administration seen previously. PMID: 30860684 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 14, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Uterine torsion in the second trimester of pregnancy.
CONCLUSIONS: Uterine torsion may present with non-specific symptoms or be asymptomatic. Urgent laparotomy and rotation of the uterus into its normal anatomical position gives chance for normal course of pregnancy. Subsequent close outpatient care is obligatory to asses viability of the fetus and early detection of possible pregnancy complications. PMID: 30796791 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Metabolic and neurobehavioral response following intraovarian administration of autologous activated platelet rich plasma: First qualitative data.
CONCLUSION: This investigation is the first to document responses across neurobehavioral and metabolic parameters after ovarian PRP. Injection of PRP-derived growth factors directly into ovarian tissue seems to enable a local signaling milieu favoring development of hormonally active ovarian elements, thus "re-potentiating" low or absent reserve. PMID: 30796792 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Metabolic characteristics of women diagnosed with polycystic ovary syndrome (PCOS) according to the Rotterdam criteria - our own experience.
CONCLUSIONS: The metabolic characteristics of women diagnosed with the PCOS according to the Rotterdam criteria can be variant. PCOS is not necessarily connected with insulin resistance and obesity. Diagnosis of PCOS does not determine metabolic state of the individual so it should be postulated that every diagnosis of PCOS should by specified by information about the phenotype. Only precise information about the phenotype allows assessing the metabolic and cardiovascular risk and introducing optimal treatment. PMID: 30796793 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Toxicity of wastewater from health care facilities assessed by different bioassays.
CONCLUSION: The study demonstrated different levels of toxicity of treated hospital wastewater. Variable sensitivity of individual bioassays for tested wastewater samples was recognized. A more extensive study including proposal for improvement of hospital wastewater treatment within the Czech Republic can be recommended with the aim to decrease the discharge of toxic chemicals into the local sewage system and the environment. PMID: 30796794 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Composition of tissue fatty acids of phospholipids depends on tumor localization and disease progression in colorectal patients.
Authors: Abstract OBJECTIVES: Fatty acids play a role in development and progression of colon cancer. The aim of this study was to assess the relation between tissue fatty acids (saturated fatty acids, unsaturated fatty acids, the ratio of C18 to C18:1 - index of fatty acids saturation, SI), colorectal tumor localization and disease progression. METHODS AND RESULTS: Total of 49 patients (14 with proximal colon, 13 with distal colon and 22 with rectal tumor localization) were studied. One year after surgery 24 patients had the disease progression. Tissue levels of saturated fatty acids and unsaturated fatty aci...
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Efficacy of endovascular intervention in patients with unruptured posterior communicating artery aneurysm-related oculomotor nerve palsy.
CONCLUSION: ONP secondary to un-ruptured aneurysm should be treated as a unique entity from its ruptured counterparts. A prospective study that contains surgical clipping and endovascular coiling, and comparison between two treatment modalities would be more convincing and is anticipated. PMID: 30796796 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Evaluation of platinum nanoparticles ecotoxicity using representatives of distinct trophic levels of aquatic biocenosis.
CONCLUSION: The ecotoxicity of platinum nanoparticles varies considerably according to the test organisms and particle size. PMID: 30796797 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Diagnosis of cerebral venous thrombosis: a single centre experience.
CONCLUSION: Cerebral venous thrombosis has a variable clinical course and the diagnosis is determined a relatively long time after the onset of symptoms. Atypical headache in the patient's history and a set of risk factors are the key findings for indication of imaging methods and confirmation of the diagnosis. PMID: 30796798 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Encephalitis with anti-NMDA receptor antibodies: paraneoplastic or non-paraneoplastic?
We report the case of an encephalitis patient with anti-N-methyl-D-aspartate receptor (NMDAR) antibody positivity. Anti-NMDAR encephalitis is a relatively rare autoimmune disease. In our patient, the diagnosis of anti-NMDAR encephalitis was established as late as several months after the first manifestations of the condition. Further development demonstrated that the patient probably suffered from a paraneoplastic form of the disease, although the presence of an underlying tumour was not detected by the available imaging methods at the time of diagnosis. The case is a rarity since the disease usually affects females, and o...
Source: Neuroendocrinology Letters - January 23, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Insulin resistance - "the good or the bad and ugly".
Insulin resistance - "the good or the bad and ugly". Neuro Endocrinol Lett. 2018 Dec 22;39(5):355-362 Authors: Szosland K, Lewinski A Abstract Insulin resistance (IR) is a state of decreased sensitivity or responsiveness of target tissues to metabolic actions of circulating insulin. IR can be selective, involving only certain aspects of insulin action, i.e. only its impact on hepatic glucose disposal. Plasma insulin concentration is a continuous variable, dependent upon several physiological stimuli, thus the thresholds used to diagnose IR are arbitrary. Insulin resistance (impaired insulin a...
Source: Neuroendocrinology Letters - January 23, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Mu Opioid Receptor Regulation of Gonadotropin-Releasing Hormone-Luteinizing Hormone Axis during Short-Term Food Deprivation: Role of Alpha1-Adrenoreceptor Signaling.
CONCLUSIONS: Current data implicate mu-R in FD attenuation of the E positive-feedback - induced LH surge. Results imply that FD-triggered noradrenergic input to the GnRH-I/LH axis acts in part to enhance reproductive neuroendocrine sensitivity to mu-R inhibition. Further studies are needed to characterize the neurochemical phenotype of AVPV and MPN neurons that express α1A- and/or mu-R, and to determine how these cells are organized within regulatory pathways to impose FD restraint of GnRH-1. PMID: 30664341 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - January 23, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Sequencing of the insulin receptor (INSR) gene reveals association between gene variants in exon and intron 13 and schizoaffective disorder.
CONCLUSION: The results of this study show that two gene variants in exon and intron 13 of the insulin receptor gene confer risk specifically for schizoaffective disorder. PMID: 30664342 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - January 23, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Accumulation of selected metals pollution in aquatic ecosystems in the Smeda river (Czech republic).
Authors: Dvorak P, Andreji J, Faltová Leitmanová I, Petrách F, Mraz J Abstract OBJECTIVES: Biomonitoring of some slelected heavy metals in the Smeda river (Czech Republic) was carried out during 2015-2016 to assess the extent of environmental pollution. Attempts were also made to map the intensity of bioaccumulation in brown trout which was used as an indicator species. Monitoring of the environmental pollution of the Smeda river was carried in 2016. DESIGN: Concentrations of some heavy metals i.e. Mercury (Hg), Lead (Pb), Cadmium (Cd) and Cobalt (Co) were quantified in the fish muscles. Co...
Source: Neuroendocrinology Letters - January 23, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Comparison of gait kinematics between professional ballet dancers and non-dancers.
Authors: Janura M, Tepla L, Strakova P, Kubonova E, Svoboda Z, Javurek F Abstract OBJECTIVES: The aims of the study were to assess the kinematics of the lower limbs and pelvis during normal walking in professional ballet dancers and to investigate relationships between movements of segments of the lower limbs and pelvis. METHODS: Thirty one professional ballet dancers and twenty eight controls completed five walking trials at their preferred speed. Kinematic data in the basic anatomical planes for ankle, knee, and hip joints as well as for the pelvis were collected with an optoelectronic motion system. RESU...
Source: Neuroendocrinology Letters - January 23, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Mathematical evaluation of melatonin secretion in hypoxic ischemic encephalopathy.
Authors: Paprocka J, Kijonka M, Borys D, Emich-Widera E, Wojcieszek P, Sokół M Abstract OBJECTIVES: The aims of the study were to assess the kinematics of the lower limbs and pelvis during normal walking in professional ballet dancers and to investigate relationships between movements of segments of the lower limbs and pelvis. METHODS: Thirty one professional ballet dancers and twenty eight controls completed five walking trials at their preferred speed. Kinematic data in the basic anatomical planes for ankle, knee, and hip joints as well as for the pelvis were collected with an optoelectronic motion sy...
Source: Neuroendocrinology Letters - January 23, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Assessing the awareness of Czechs, age 40+, on the link between lifestyle choices and risk factors for cardiovascular diseases.
This article assesses the understanding of risk factors that can lead to the development of heart and vessel diseases. METHODS: A non-standardized questionnaire was used for data collection. The respondents expressed their opinions on influenceable factors using a five-degree Likert scale. The research set included 1,992 respondents. Data were statistically analyzed using the SASD program, version 1.4.12. To calculate the level of dependence of the selected characteristics, the Wallis, and Spearman correlation coefficients were calculated. The goodness-of-fit χ2 was applied as well. RESULTS: The results show th...
Source: Neuroendocrinology Letters - January 23, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Selected bisphenols and phthalates screened for estrogen and androgen disruption by in silico and in vitro methods.
CONCLUSION: Our results suggest multiple parallel interactions of tested compounds and emphasize the importance of determination of an appropriate battery of in vitro methods that will include more receptors and will be appropriate to target specific molecular mechanisms involved in endocrine disruption. Results in agonistic studies indicate agonistic potential and are supported by results of antagonistic studies with consideration of possible multiple interactions. PMID: 30664347 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - January 23, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Evaluation of the effectiveness of treatment of vulvar lichen sclerosus et atrophicus. Analysis of own material and review of the literature.
CONCLUSIONS: Vulvar lichen sclerosus et atrophicus is a chronic condition requiring long-term treatment. Topical use of steroids as first-line drugs bring a good local control of lesions in most women, yet further search of other possible causes of LSA is necessary. PMID: 30664348 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - January 23, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Bisphenol A as an environmental pollutant with dual genotoxic and DNA-protective effects.
CONCLUSIONS: BPA itself does not induce genotoxic effect to DNA. However, BPA treatment of human lymphocytes leads to the induction of DNA damage. The proposed mechanism of BPA action in the human lymphocytes could be mediated by cell metabolism that induces an oxidative stress and ROS formation. ROS subsequently attack DNA and thus induce DNA damage. According to our results, BPA can be included in the group of substances with dual effects involving genotoxic and DNA-protective activity. PMID: 30531698 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 13, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Depressive symptoms are associated with higher morning plasma cortisol in primary care subjects.
CONCLUSION: Depressive symptoms in primary care subjects not consulting for their mood are associated with higher morning plasma cortisol, but not urinary cortisol or its metabolites. These observations suggest that systemic hypercortisolism and related metabolic disorders are not observed in mild/initial states of depressive disorders. PMID: 30531699 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 13, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Endocrine response to high intensity barbell squats performed with constant movement tempo and variable training volume.
Authors: Wilk M, Petr M, Krzysztofik M, Zajac A, Stastny P Abstract OBJECTIVE: Research indicates that among the many elements of resistance exercise protocols, training volume and total training load are the key factors for post-exercise increase in the secretion of testosterone (T), growth hormone (GH), insulin-like growth factor (IGF-1) and cortisol (C). The aim of this study was to determine the effects of resistance exercises with variable volume and constant intensity and movement tempo on post-exercise concentrations of selected anabolic and catabolic hormones. MATERIALS AND METHODS: 28 experienced power...
Source: Neuroendocrinology Letters - December 13, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Gamma knife radiosurgery for local recurrence of glioblastoma.
CONCLUSION: We show that LGK radiosurgery is a safe palliative treatment modality in patients with recurrent GBM. PMID: 30531701 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 13, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Human mature milk zearalenone and deoxynivalenol levels in Turkey.
CONCLUSIONS: Our findings are indicative of dietary exposure to mycotoxins during the pregnancy and lactation periods in nursing mothers. Further, the excessive TDI values for DON observed in 36% of the exclusively breastfed infants point to the need for further regulations and recommendations on the dietary habits of pregnant/nursing mothers in order to avoid exposure to potential mycotoxins. PMID: 30531702 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 13, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Levels of selected contaminants in fish muscle from upper Nitra River.
CONCLUSIONS: The Slovak permissible limits for safe consumption, defined in the Commission Regulations No. 1881/2006 and 629/2008, in the case of Pb, Cd and Hg were exceeded in 10%, 63% and 0%, respectively. PMID: 30531703 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 13, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Light-dark influence on enkephalinase activity in hypothalamus and pituitary.
CONCLUSION: These results may reflect the behaviour of the endogenous substrates of enkephalinase and consequently be involved in their functions. This observation may affect the chronotherapeutic strategies. PMID: 30531704 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 13, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Locomotion in young rats with induced brain cellular edema - effects of recombinant human erythropoietin.
CONCLUSION: Presented results demonstrate the neuroprotective capacity of rhEPO, manifested by elimination of the suppressive influence of CE on the locomotion in 35-day-old rats. In 25-day-old rats the neuroprotective effect was not present. These results confirmed that the 10 day interval in the development may represent a different stage of brain maturation in the relation to the neuroprotective effect of rhEPO. PMID: 30531705 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 13, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Regional differences in somatostatin receptor 2 (SSTR2) immunoreactivity is coupled to level of bowel invasion in small intestinal neuroendocrine tumors.
CONCLUSIONS: This observation indicates a down-regulation of SSTR2 expression as the tumors progress through the intestinal wall, which might signify underlying biological processes of importance for SI-NET invasion behavior. PMID: 30531706 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 13, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The assessment of retina in pregnant women with myopia.
Authors: Moneta-Wielgos J, Brydak-Godowska J, Golebiewska J, Lipa M, Rekas M Abstract OBJECTIVES: Myopia is associated with increased frequency of retinal degenerative changes which are the risk factors of intra- and postpartal ophthalmological complications. Aim of this study was to analyze the degenerative lesions detected in opthalmological examination (including peripheral retinal lesions) as a potential risk factors for eyes' status in terms of delivery in myopic women. MATERIAL AND METHODS: 254 pregnant women affected with myopia underwent opthalmological examination as a screening method to examine retin...
Source: Neuroendocrinology Letters - December 13, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The effect of silver nanoparticles and silver ions on zebrafish embryos (Danio rerio).
CONCLUSION: Properties of different silver nanoparticles play an important role in levels of their toxicity and predominant mechanisms of action. In general, silver nanoparticles are less toxic for Danio rerio embryos than silver ions. PMID: 30531708 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 13, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Three diagnostic psychiatric subgroups in comparison to self-stigma, quality of life, disorder severity and coping management cross-sectional outpatient study.
CONCLUSIONS: The investigation confirmed the connection between the quality of life, self-stigma, coping strategies, and the severity of the illness, in outpatients with schizophrenia spectrum disorders, depressive, and neurotic spectrum disorders. A further longitudinal study would be useful to determine the causative relationships of these variables. PMID: 30531709 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 13, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

25(OH)D serum concentration in women with menstrual disorders -risk factors for Vitamin D deficiency.
Authors: Abstract INTRODUCTION: Vitamin D (VD) plays a crucial role in calcium metabolism as well as immunological and endocrine homeostasis. Previous studies revealed strong inverse correlation between VD levels and insulin resistance, parathyroid dysfunctions and autoimmune thyroid disease. Insufficient evidence concerns its dependency of ovarian hormones. Malfunctioning of the ovaries results in menstrual disorders that are one of the most common endocrine impairments in young women of reproductive age. MATERIAL AND METHODS: The study was aimed to evaluate the correlation between 25(OH)D serum concentration...
Source: Neuroendocrinology Letters - November 17, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

A rare case of ectopic pregnancy - retroperitoneal ectopic pregnancy.
Authors: Abstract Ectopic pregnancy is a condition when fertilized egg implants outside the uterine cavity. The reported incidence is about 0.5-1% of all pregnancies. Retroperitoneal ectopic pregnancies (REP) are extremely rare and early diagnosis and treatment is very difficult. For the adequate management and elimination of risks of maternal morbidity and even mortality, timely diagnosis is of a key importance. A 38-year-old woman was referred to our department for RCUI due to missed abortion/anembryonic pregnancy. Re-RCUI was later indicated due to suspicion of residua post RCUI. Histological examination didn't...
Source: Neuroendocrinology Letters - November 17, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Cellular brain edema induced by water intoxication in rat experimental model.
CONCLUSION: Our experimental model can help the future studies of pathophysiology of cellular brain edema and is suitable for testing neuroprotective agents. PMID: 30431738 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - November 17, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Clinical effectiveness of parenteral trazodone for the management of psychomotor activation in patients with bipolar disorder.
Authors: Abstract OBJECTIVES: Trazodone is a multifunctional triazolopyridine drug with antidepressant, anxiolytic, sedative, and hypnotic properties. The current retrospective study was designed to investigate the effectiveness of trazodone for reducing acute psychomotor activation (PA) in patients with bipolar disorder (BD). We specifically reasoned that a parenteral route of administration could offer potential advantages in this clinical setting. METHODS: We assessed the effectiveness and safety of parenteral trazodone in a retrospective study conducted in 64 inpatients with BD and acute PA. The effec...
Source: Neuroendocrinology Letters - November 17, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Coexistence of neurofibromatosis type 1 with multiple malignant neoplasia.
Authors: Abstract Neurofibromatosis type 1 (NF1, von Recklinghausen disease) is inherited in autosomal dominant way genetic disorder, with an incidence at birth 1:3000. It is one of the most common congenital disorders. It is characterized by café-au-lait spots, neurofibromas, and less common MPTST and gliomas of the optic nerve. It is caused by germline mutations of the NF1 gene, which acts as tumor suppressor. Inactivation of the gene leads to increased activation of the kinase pathways, and in consequence, uncontrolled proliferation of cells. The disease predisposes to the development of both benign and ...
Source: Neuroendocrinology Letters - November 17, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Hypophysitis and other autoimmune complications related to immune checkpoints inhibitors ´ treatment: Spectrum of imaging appearances.
CONCLUSION: Secondary hypophysitis is probably more common ICI related adverse event than reported in the literature. Its MRI appearance is variable. Most of our cases were in coincidence with other AI ICI related events that affected their clinical manifestations. PMID: 30431741 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - November 17, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research