Acute and chronic stress exert opposite effects on formation and contextualrelated fear conditioning in rats.
CONCLUSION: Our findings revealed acute and chronic stress led to distinct behavioral responses in fear conditioning and indicated CRFR1 is involved in the interaction of stress and fear conditioning, which help understand the connection between stress and fear memory. PMID: 31785211 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Risk of delayed diagnosis in young patients with left ventricular non-compaction - a potential benefit of magnetic resonance imaging.
CONCLUSIONS: The high variability of morphological findings and clinical manifestations of LVNC results in frequent overlooking of this disorder. Therefore, it is important to make the specialists more familiar with this condition and its pathology. Magnetic resonance imaging represents a conducive method to make correct diagnosis of LVNC under several specific conditions, particularly in case of non-conclusive echocardiographic finding. PMID: 31785212 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Effect of vitamin D deficiency on BMI in patients treated with Multi-acting Receptor Target Antipsychotics.
CONCLUSION: Vitamin D deficiency could be a risk factor for MARTA-induced weight gain. Further studies are necessary to replicate this finding. PMID: 31785213 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The clinical course and outcome of Listeria monocytogenes meningitis: A retrospective single center study.
Authors: Abstract BACKGROUND: The aim of the study was to determine clinical manifestations and outcome of Listeria monocytogenes meningitis (LM) and to compare with other forms of bacterial meningitis (BM). MATERIAL AND METHODS: We analyzed records of all adult patients with BM who were hospitalized between January 2010 and December 2017 in the largest neuroinfection center in Poland. RESULTS: Out of 343 analyzed patients with BM 24 were diagnosed to have LM. Patients with LM were older compared to patients with other forms of BM (62 years vs. 57 years, p=0.039), were more likely to have cancer (16.7% vs....
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome.
Authors: Abstract OBJECTIVES: Sleep apnea syndrome affects approximately 4% of adult males and 2% of adult females. It is associated with significant cardio-, cerebrovascular, metabolic and hormonal comorbidities and ranks among the more expensive medical specialties due to the requirement of high-quality technical diagnostic and therapeutic equipment as well as well-educated and experienced personnel. The aim of this study is to detect the relationship between C-reactive protein (CRP), pentraxin-3 (PTX-3), interleukin 6 (IL6), high-sensitivity troponin I (hsTnI), brain natriuretic protein (BNP) and galectin-3 ser...
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education.
Authors: Abstract PURPOSE: SIR proteins (silent information regulators, sirtuins, SIRT1 - SIRT7, SIR1 - SIR7) belong to NAD+-dependent deacetylases, enzymes taking part in a catalytic reaction of deacetylation, i.e. splitting the rest of acetic acid from protein substrates. Sirtuins play an important role in many cellular processes and are, therefore, involved in the ageing process and in the regulation of cell life. The aim of this paper is to verify the statistical hypothesis assuming the correlation between the age and level of education of examined persons and the expression of selected sirtuins (SIR1 - SIR7, ...
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Primary pituitary abscess case series and a review of the literature.
CONCLUSION: Presentation of fever, headache, diabetes insipidus, hypopituitarism and a sellar cystic mass with an enhanced rim after gadolinium contrast on pituitary magnetic resonance imaging may be suggestive of a pituitary abscess. Transsphenoidal endoscopic surgery, proper antibiotics and appropriate hormone replacement therapy when necessary are the keys of pituitary abscess treatment. PMID: 31785217 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Positive TgAbs in patients with Graves' orbitopathy are associated with lower risk of its active form - preliminary study.
Authors: Wojciechowska-Durczynska K, Zygmunt A, Matusiak A, Karbownik-Lewinska M, Lewinski A Abstract INTRODUCTION: In this retrospective, single-centre cohort study, we report our 10-year experience concerning clinical manifestation, diagnosis and treatment of Graves' orbitopathy (GO), with particular regard to antithyroid antibodies in iodine sufficient Polish population. MATERIALS AND METHODS: Data on thyrometabolic and immunological status of 71 patients diagnosed with GO, were collected. Also, we gathered information on the selection of the applied treatment in these cases of Graves' disease (GD): pharmaco...
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Selected topics in public health - Editorial.
Authors: Abstract In 2019, there were several new epidemics of diseases around the world, which would only be known from old medical books. Conspiracy and antivax movements around the world have raised important issues about public health, its safety, prevention and the media. The importance of public health is increasing more than ever. That is why we are very pleased that we have succeeded in collecting enough quality articles to present a collection of papers this year again. We have a great need for quality data to combat disinformation, hoaxes and lies. But we also have a greater need to deliver this informat...
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Anaphylaxis in Public Health.
Authors: Abstract The increasing number of patients with anaphylactic reactions is a modern challenge for healthcare professionals in clinical practice and public health professionals. It remains difficult to determine the prevalence or incidence of anaphylaxis in the population due to the long absence of a consensus definition, the fact that analyses are performed on various population groups and the use of different data collection methodologies. In the United States, anaphylaxis mortality ranges from 0.63 to 0.76 cases per million inhabitants, with 58% of these deaths due to drug anaphylaxis. The risk factors f...
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Suicides by ingestion of pure caffeine powder. New challenge for public health?
CONCLUSIONS: The presence of caffeine only at the concentration of 362 ug/mL in blood and 187 ug/mL in urine was revealed. The cause of death was cardiac arrest most likely due to ventricular dysrhythmia. The concentration of caffeine determined in the femoral blood of the decedent was three times higher than the lethal concentrations reported in other published case studies. Based on the investigated circumstances, the manner of death was evaluated as a suicide. PMID: 31785221 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Analysis of body segments and postural state in school children.
CONCLUSION: Health status of the children's locomotor system, especially postural system is poor. High prevalence of postural disorders in children requires preventive programs such as introducing corrective exercises into physical education and engaging children in sports. Knowledge of the most frequent body segments defects in children can be helpful for professionals in creating adequate corrective programs for children. PMID: 31785222 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The Health Impact of Mineral Dust Air Pollution on the Global and Local Scale (on the example from Slovakia).
CONCLUSIONS: Mineral composition and morphology of dust fallouts in the air from mining areas directly affects the health of the population and contributes to the increased incidence of respiratory diseases in the region, even several years after closing the mines or after the change of filters in mineral processing plants. Reducing unwanted air pollution should be a priority for relevant ministries (of health, environment etc.), as well as a challenge for public health professionals. PMID: 31785223 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Extraordinary features of the intraspinal extradural and intradural nerve root courses.
CONCLUSIONS: This study allowed us to identify and describe current occurence of intraspinal extradural and intradural communicating branches in the spinal canal with their potential influence on the clinical picture. Anatomical preparations revealed a higher incidence of intraspinal intradural variations, particularly between sacral roots. The reliance of their incidence of the type of plexus was observed. PMID: 31785224 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Colonisation of Staphylococcus aureus in patients with Nasal Polyposis.
CONCLUSION: Our results did not show that S. aureus found in nasal mucosa membrane is significantly different in patients with or without NP. However, association of the presence of S. aureus in patients with nasal polyposis with asthma, allergy and inflammation has been shown. PMID: 31785225 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Slovak and Czech OECD Data under the Magnifying Glass: Cardiovascular Pharmaceutical Consumption by Defined Daily Dose.
CONCLUSION: Our results indicate that, when actual DDDs for both countries are used, cardiovascular pharmaceutical consumption in the Slovak Republic is shown to be lower than in the Czech Republic. PMID: 31785226 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Occurrence of periadrenal brown adipose tissue in adult Slovak population.
CONCLUSIONS: Brown adipose tissue cells were found in 240 (63%) cases. The prevalence of brown adipose tissue decreases below the age of 50 and later slightly increases. No significant differences in the prevalence of brown adipose tissue between men and women were found. With the exception of Germany, this study is currently the first extensive morphological autopsy study of brown adipose tissue prevalence in adults in Central and Eastern Europe. PMID: 31785227 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The Lindau Nobel Laureate Meeting 2018: Added value - and reflection - for participants, institutes and disciplines.
Authors: Lewis P, Erren TC Abstract Since 1951, Lindau Nobel Laureate Meetings have promoted scientific exchange between laureates and young researchers across generations and cultures. In 2018, the conference on Lake Constance focusing on "Physiology/Medicine" brought together 39 Nobel Laureates and 600 young scientists from 84 countries. This empirical contribution illustrates added value that the extraordinary offer of knowledge and experience by so many Nobel Laureates has for young participants, institutes and disciplines, and it provides reflection. PMID: 31184815 [PubMed - as supplied by publis...
Source: Neuroendocrinology Letters - June 13, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Clinical attitude to the patient with Non-syndromic Pierre Robin Sequence with the cleft of soft palate and uvula - The necessity of fibroscopic investigation.
Authors: Koukouvitaki M, Arkoumanis PT, Brucknerova J, Brucknerova I Abstract Pierre Robin sequence is defined by a triplet of clinical signs in newborns: micrognathia, glossoptosis and tongue-based airway obstruction often accompanied by U-shaped cleft palate. The reported incidence is ranging from 1 to 8.500 to 30.000 newborns. Therapeutic management of Pierre Robin sequence is based on the degree of the airway obstruction. A priori management of such cases can be extremely challenging due to the phenotypic plethora of Pierre Robin Sequence. A ten-day male newborn diagnosed with Pierre Robin was referred to ...
Source: Neuroendocrinology Letters - June 13, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Critical periodic systemic blood pressure fluctuations during pulmonary valve replacement cardiac surgery in a patient with an incidentally discovered normotensive pheochromocytoma-A case report.
Authors: Zhao J, Cheng D, Hou L, Lei C Abstract Standard management protocols for patients with pheochromocytoma (PHEO) have been described in current guidelines. However, the standard management approach for cardiac surgical patients with concurrent clinically silent PHEO has not been established yet. The effects of open heart surgery and cardiopulmonary bypass (CPB) on PHEO presentation are poorly documented. Here, we report in detail the anesthetic management and hemodynamic changes in a case of CPB-assisted pulmonary valve replacement surgery with an incidentally discovered normotensive PHEO. A 55-year-old male...
Source: Neuroendocrinology Letters - June 13, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Lithium intoxication in the pre-hospital care with stroke symptoms - Case report.
Authors: Peran D, Pukovcova K, Pekara J, Nesvadba M, Nedved V, Christian Cmorej P, Cmorej PC, Bohm P, Mamova A Abstract Lithium is widely used in psychiatry to treat bipolar affective disorders since 1970 but little is known about the incidence, clinical course and associated factors of acute lithium intoxication. Moderate and severe cases of lithium intoxication are rare. This case reports a patient with acute lithium intoxication (serum level of 3.7 mmol/L) with neurological symptoms imitating stroke, which affects the differential diagnosis in the pre-hospital and hospital care. Patient was treated with forced d...
Source: Neuroendocrinology Letters - June 13, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The Effect of Cold Water Immersion on Cardiac Troponin T and Myoglobin Levels.
CONCLUSIONS: In this study, cTnT level, which is regarded as one of the most specific markers of cardiac injury, was found to be lower in the athletes who underwent cold water immersion. These results indicate that the recovery time may be shorter in athletes undergoing cold-water immersion. PMID: 31184819 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - June 13, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Dysregulation in IGF-1R, FGFR4 and ╬▓Klotho signaling in patients with medullary thyroid cancer.
CONCLUSIONS: Our results indicate that a disrupted signaling pathway for βKL, FGFR4 and IGF-1R may play a role in the development of medullary thyroid cancers. However, further studies are required to confirm these findings and to use this knowledge in clinical practice. PMID: 31184820 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - June 13, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

A Distinct Clinical Phenotype in Two Siblings with X-linked Adrenoleukodystrophy.
CONCLUSION: Two siblings with X-ALD due to presumably an identical, missense ABCD1 mutation and distinct clinical phenotype have confirmed the lack of phenotype-genotype correlation and proved the essential role of molecular genetics analysis in the early diagnosis. It is crucial to follow up for the development of cranial involvement and decide a bone marrow transplantation which is the only option that can prevent the progression of the disease, thus extend the lifespan. PMID: 31184821 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - June 13, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Comparison of Prostate Imaging Reporting and Data System (PI-RADS) version 1 and version 2 and combination with apparent diffusion coefficient as a predictor of biopsy outcome.
CONCLUSION: PI-RADS version 2 exhibited significantly higher discriminative ability for PCa and CSPCa detection compared to PI-RADS version 1. Using the ADC can improve the tumor predictability of PI-RADS version 2 in lesions scored 4. PMID: 31184822 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - June 13, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Fasting serum leptin levels in elderly women with major depressive disorder: a case-control study.
CONCLUSIONS: In two groups of subjects with comparable adiposity parameters we did not confirm that leptin level is changed in patients with depression. We assume that changes in leptin level in patients with depression may be mediated by adiposity. PMID: 31184823 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - June 13, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Fructose-1,6-bisphosphatase deficiency presented with complex febrile convulsion.
Authors: Abstract Fructose-1,6-bisphosphatase (FBPase) deficiency is a rare inborn error of metabolism affecting gluconeogenesis caused by FBP1 gene mutations. It could be more fatal to infants and children when glycogen reserves are insufficient. A 4-year-old girl was admitted with complex febrile convulsion. Initial laboratory results showed hypoglycemia, metabolic acidosis, and hyperlactatemia. Plasma amino acid and urine organic acid analyses showed increased levels of alanine and tricarboxylic acid cycle intermediates. However, she had similar clinical features, including confusion under severe hypoglyce...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Therapy for Gastroenteropancreatic Neuroendocrine Tumors: drug evaluation reports review in Spain.
CONCLUSIONS: Everolimus and sunitinib are new drugs available for the treatment of GEP NET patients reported to have promising effects in advanced diseases. However, the reports are limited and thus new clinical studies on the impact of these drugs on clinical outcome, prognosis, financial burden and feasibility are necessary to support further recommendations. PMID: 30927758 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Etiology, Risk Factors and Outcome of 1003 Cases of Infective Endocarditis from a 33-year National Survey in the Slovak Republic: An increasing proportion of elderly patients.
Authors: Abstract BACKGROUND: Infective endocarditis (IE) is still a significant cause of mortality in European hospitals, despite of the fact, that large nationwide studies were performed in last twenty years and pathogens are well known. The aim of the study was to assess risk factors, mortality, etiology and proportion of elderly patients within a longitudinal nation wide survey of infectious endocarditis in Slovakia. PATIENTS AND METHODS: Etiology, risk factors and outcome of 1003 cases of infective endocarditis (IE) in Slovakia over the last 33 years have been assessed. RESULTS: The majority of IE wer...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The influence of electromagnetic fields generated by wireless connectivity systems on the occurrence of emotional disorders in women: A preliminary report.
CONCLUSIONS: The study showed that exposure to electromagnetic fields from GSM 900 and 1800 generated by base stations contributed to the occurrence of depressive disorders among medical personnel, while exposure to WLAN EMF had the opposite effect. Spending time on phone conversations decreased the feeling of depression and increased trait anxiety in medical staff. Spending free time on physical activity intensified depressive states in women working in trade. Further studies on the influence of low-frequency EMFs on the human nervous system are needed. PMID: 30927760 [PubMed - as supplied by publisher] (Source: Neuro...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Thioredoxin is a potential therapy for light-induced photoreceptor degeneration in diabetic mice.
Authors: Abstract BACKGROUND: Retina degeneration is a set of disease that can be characterized by progressive loss of rod or cone photoreceptors that can experience higher light exposure compared with other parts of our body. MATERIAL AND METHODS: To investigate in diabetic mice the effects of different light on retinal photoreceptor and its related mechanisms, 4-6 weeks male Balb/c mices were randomly divided into control group, light treatment group (light 1 and light 2), light treatment with filter membrane group (LFM1 and LFM2), light treatment filter blue light group (LFB), diabetic group (DM), diabetic ...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Tissue metallothionein response in the Japanese quail associated with exposure to cyanobacterial biomass, lead and the Newcastle disease virus.
Authors: Abstract OBJECTIVES: Here we tested the hypothesis that multiple toxic and infectious stressors combine in their adverse effects to produce higher tissue responses of metallothioneins (MTs) in birds. METHODS: We used Japanese quails as a model avian species. The study is based on data obtained from single and combined exposures of Japanese quails to cyanobacterial biomass containing microcystins, lead and a live Newcastle disease vaccination virus. Eight groups of 5 birds were exposed to single, double and triple combinations of these stressors and compared with controls. Birds were euthanized after t...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The association of serum lipid level with ischemic stroke in the elderly of Xinjiang.
Authors: Abstract BACKGROUND: The aim of the present study is to determine the association of serum lipid level in the above 55-year-old age elderly with ischemic stroke (IS) in Xinjiang regions, China. METHODS: 408 patients with IS and 347 healthy individuals as control in the ≥55-year-old elderly were selected for the present study in Xinjiang province of China from July 2010 to July 2012. Patients were divided into different groups according to the IS subtypes (large-artery atherosclerosis, LAA; cardio-aortic embolism CE; small-artery occlusion, SAO), plague stability, hypertension and diabetes. The seru...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Angiotensinogen gene T174M polymorphism is related to Hashimoto's thyroiditis.
Authors: Abstract OBJECTIVES: The Hashimoto thyroiditis is found to be Th1-related autoimmunity. Recently, it has been proved that the renin-angiotensin-aldosterone system (RAAS) may be involved in promoting Th1-mediated autoimmune diseases. However, the role of RAAS in HT pathogenesis remains still unknown. The aim of this study was to determine whether the polymorphisms of ACE, AGTR1 and AGT genes are associated with HT. MATERIAL AND METHODS: Polymerase Chain Reaction (PCR) was performed to determine ACE I/D, AGTR1 A1166C and AGT T174M polymorphisms and next chi-square test was used to compare allele frequen...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Selected Risk Factors of Falls in Hospitalized Patients: A Case-Control Study.
CONCLUSION: Interventions aimed at prevention of falls should be included in care plans, especially for older patients, patients who have fallen in the past, patients who have movement restriction, patients with cognitive dysfunction, and patients with increased need of assistance with basic daily activities. PMID: 30860679 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 14, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Clinical characteristics of subacute thyroiditis is different than it used to be - current state based on 15 years own material.
CONCLUSION: In our study, several new features of current SAT course, different from what we used to know about the disease, were reported. Higher frequency of painless SAT than it was ever described, was observed. Moreover, in as much as one third of the patients aTPO and/or aTg were present, and in 6% of SAT cases the coexistence of TRAb was demonstrated. Transient microhaematuria was typical for the acute SAT phase. PMID: 30860680 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 14, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Tapentadol in an Experimental Animal Model of Acute Orofacial Pain.
Authors: Abstract OBJECTIVE: Tapentadol exhibits a synergistic dual effect effect (MOR / NRI) -agonist effect on noradrena-line reuptake inhibition (NRI). Tapentadol is effective on pain with neuropathic characteristics, therefore we decided to use it in an experimental model of acute orofacial pain. METHODS: The Orofacial Stimulation Test, developed by Ugo Basile, measures hypersensitivity to thermal or mechanical stimulation of the trigeminal area. In the experiment, rats had to voluntarily contact a thermal or mechanical stimulator with their unshaved vibrissal pad in order to access a food reward. Twenty a...
Source: Neuroendocrinology Letters - March 14, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Potential of the multivitamin-mineral-trace element composition LaVita ® before, during and after pregnancy.
CONCLUSION: The regular intake filled up the respective storage compartments and reservoirs in the tissues, and improved the metabolic status. Female participants tended to benefit more than male. We conclude that the composition is safe, and warrants optimized micronutrient supply during pregnancy or postnatal breastfeeding. PMID: 30860682 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 14, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro.
CONCLUSION: The results found demonstrate that TKIs vandetanib, lenvatinib and cabozantinib cause a decrease in oxidative activation of DNA-damaging drug ellipticine by several CYP enzymes in vitro which might lead to a decrease in its pharmacological efficiency. In contrast, they practically do not influence its detoxification catalyzed by CYP1A1, 1A2 and peroxidases. The present study indicates that tested TKIs seem not to have a potency to increase ellipticine anticancer efficiency. PMID: 30860683 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 14, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Effects of peripheral administration of GH and IGF-I on gene expression in the hippocampus of hypophysectomised rats.
CONCLUSION: The 19-day GH-infusion induced similar effects as those reported after 6-day GH treatment, with the addition of the regulation of transcript Alox15. IGF-I induced altered gene expression in relation to its effect on weight gain. This study underlines that there is an entity of transcripts involved in neuroprotection and vascular tone that is regulated by both systemic GH and IGF-I. For other transcripts, the longer duration of this study did not significantly enhance the marginal effects of GH administration seen previously. PMID: 30860684 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 14, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Uterine torsion in the second trimester of pregnancy.
CONCLUSIONS: Uterine torsion may present with non-specific symptoms or be asymptomatic. Urgent laparotomy and rotation of the uterus into its normal anatomical position gives chance for normal course of pregnancy. Subsequent close outpatient care is obligatory to asses viability of the fetus and early detection of possible pregnancy complications. PMID: 30796791 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Metabolic and neurobehavioral response following intraovarian administration of autologous activated platelet rich plasma: First qualitative data.
CONCLUSION: This investigation is the first to document responses across neurobehavioral and metabolic parameters after ovarian PRP. Injection of PRP-derived growth factors directly into ovarian tissue seems to enable a local signaling milieu favoring development of hormonally active ovarian elements, thus "re-potentiating" low or absent reserve. PMID: 30796792 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Metabolic characteristics of women diagnosed with polycystic ovary syndrome (PCOS) according to the Rotterdam criteria - our own experience.
CONCLUSIONS: The metabolic characteristics of women diagnosed with the PCOS according to the Rotterdam criteria can be variant. PCOS is not necessarily connected with insulin resistance and obesity. Diagnosis of PCOS does not determine metabolic state of the individual so it should be postulated that every diagnosis of PCOS should by specified by information about the phenotype. Only precise information about the phenotype allows assessing the metabolic and cardiovascular risk and introducing optimal treatment. PMID: 30796793 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Toxicity of wastewater from health care facilities assessed by different bioassays.
CONCLUSION: The study demonstrated different levels of toxicity of treated hospital wastewater. Variable sensitivity of individual bioassays for tested wastewater samples was recognized. A more extensive study including proposal for improvement of hospital wastewater treatment within the Czech Republic can be recommended with the aim to decrease the discharge of toxic chemicals into the local sewage system and the environment. PMID: 30796794 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Composition of tissue fatty acids of phospholipids depends on tumor localization and disease progression in colorectal patients.
Authors: Abstract OBJECTIVES: Fatty acids play a role in development and progression of colon cancer. The aim of this study was to assess the relation between tissue fatty acids (saturated fatty acids, unsaturated fatty acids, the ratio of C18 to C18:1 - index of fatty acids saturation, SI), colorectal tumor localization and disease progression. METHODS AND RESULTS: Total of 49 patients (14 with proximal colon, 13 with distal colon and 22 with rectal tumor localization) were studied. One year after surgery 24 patients had the disease progression. Tissue levels of saturated fatty acids and unsaturated fatty aci...
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Efficacy of endovascular intervention in patients with unruptured posterior communicating artery aneurysm-related oculomotor nerve palsy.
CONCLUSION: ONP secondary to un-ruptured aneurysm should be treated as a unique entity from its ruptured counterparts. A prospective study that contains surgical clipping and endovascular coiling, and comparison between two treatment modalities would be more convincing and is anticipated. PMID: 30796796 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Evaluation of platinum nanoparticles ecotoxicity using representatives of distinct trophic levels of aquatic biocenosis.
CONCLUSION: The ecotoxicity of platinum nanoparticles varies considerably according to the test organisms and particle size. PMID: 30796797 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Diagnosis of cerebral venous thrombosis: a single centre experience.
CONCLUSION: Cerebral venous thrombosis has a variable clinical course and the diagnosis is determined a relatively long time after the onset of symptoms. Atypical headache in the patient's history and a set of risk factors are the key findings for indication of imaging methods and confirmation of the diagnosis. PMID: 30796798 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 25, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Encephalitis with anti-NMDA receptor antibodies: paraneoplastic or non-paraneoplastic?
We report the case of an encephalitis patient with anti-N-methyl-D-aspartate receptor (NMDAR) antibody positivity. Anti-NMDAR encephalitis is a relatively rare autoimmune disease. In our patient, the diagnosis of anti-NMDAR encephalitis was established as late as several months after the first manifestations of the condition. Further development demonstrated that the patient probably suffered from a paraneoplastic form of the disease, although the presence of an underlying tumour was not detected by the available imaging methods at the time of diagnosis. The case is a rarity since the disease usually affects females, and o...
Source: Neuroendocrinology Letters - January 23, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Insulin resistance - "the good or the bad and ugly".
Insulin resistance - "the good or the bad and ugly". Neuro Endocrinol Lett. 2018 Dec 22;39(5):355-362 Authors: Szosland K, Lewinski A Abstract Insulin resistance (IR) is a state of decreased sensitivity or responsiveness of target tissues to metabolic actions of circulating insulin. IR can be selective, involving only certain aspects of insulin action, i.e. only its impact on hepatic glucose disposal. Plasma insulin concentration is a continuous variable, dependent upon several physiological stimuli, thus the thresholds used to diagnose IR are arbitrary. Insulin resistance (impaired insulin a...
Source: Neuroendocrinology Letters - January 23, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research