Are physical and mental abilities of older people related to gonadotropins and steroid hormones levels?
CONCLUSIONS: The positive correlation between SPPB scores and FSH and the negative correlations of SPPB with LH/FSH ratio were observed in men. The correlation of TUG scores and estradiol levels was also noted in men. The positive correlation between CDT scores and FSH in women and the negative correlation between CDT and LH/FSH ratio in men were found. The correlation between the results of CDT and cortisol levels in men was also observed. Thus, we did not confirm the simple deleterious effect of gonadotropins on cognitive abilities. FSH and LH seem exert different (antagonistic?) effects on cognitive functions, but this ...
Source: Neuroendocrinology Letters - April 29, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Imagery in cognitive behavioral supervision.
CONCLUSION: It is useful to integrate imagery to the supervision. Using imagery can help to understand the patient, the therapeutic relationship better, and to plan optimal therapeutic strategies, as well as reflect/self-reflect and train difficult skills which promote professional and personal growth. PMID: 32338851 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - April 29, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Insulinoma as a Potential Insidious Presenter in Medical Refractory Epilepsy.
CONCLUSION: The early diagnosis of insulinoma requires vigilance, not only for hypoglycemia in patients with neuropsychiatric symptoms, but also for the possible masking effects of a history of epilepsy and preceding AED usage. PMID: 32338852 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - April 29, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Neurofilament light chain and MRI volume parameters as markers of neurodegeneration in multiple sclerosis.
Authors: Filippi P, Vestenická V, Siarnik P, Sivakova M, Čopíková-Cudráková D, Belan V, Hanes J, Novák M, Kollar B, Turcani P Abstract BACKGROUND: Neurofilament light chain (NfL) is considered a major marker of neurodegeneration and disease activity. Higher levels of NfL are associated with worse clinical outcomes and increased brain atrophy. In treated patients with Relapsing-Remitting Multiple Sclerosis (RRMS), we aimed to determine the level of NfL, an association between NfL and demographic, clinical and magnetic resonance imaging (MRI) characteristics as well as brain...
Source: Neuroendocrinology Letters - April 29, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Response of thyrotropin-secreting pituitary tumors to preoperative lanreotide therapy. Report of two cases.
Authors: Tokutsu A, Okada Y, Torimoto K, Otsuka T, Narisawa M, Kurozumi A, Tanaka Y Abstract Case 1 was a 51-year-old man diagnosed with thyrotropin (TSH)-secreting pituitary tumor. The octreotide loading test showed suppression of TSH secretion. Treatment with lanreotide preoperatively at 90 mg/month resulted in normalization of thyroid function. Three months after treatment initiation, tumor shrinkage was observed, and pituitary tumor resection was performed through transsphenoidal surgery. Case 2 was a 47-year-old woman in whom the octreotide loading test showed suppressed TSH secretion. Treatment with lanreotid...
Source: Neuroendocrinology Letters - April 29, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Thyroid dysfunction among adults in Bahrain: A hospital-based study.
Authors: Abdulla J, Abubaker F, Saber FA Abstract OBJECTIVE: Since thyroid dysfunction is a common disorder and affecting all populations regardless of iodine status, a comprehensive evaluation of thyroid dysfunction in Bahrain is essential to draw a national strategy, increase public awareness, and recognize the role of ethnicity. METHODS: Following the approval of the Research Ethics Committee, the study was initiated by collecting laboratory and patient's data that have performed thyroid function tests (TFTs) during January 2018 till January 2019 at the Royal Services of Bahrain Defense Force (BDF) Military ...
Source: Neuroendocrinology Letters - April 29, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Normal height and novel mutations in growth hormone deficiency adults with pituitary stalk interruption syndrome.
CONCLUSION: The present cases suggest that there are exceptions in GH deficient patients where a select few can attain normal heights without GH therapy. Genetic screening can be a predictor for prognoses of rare types of hypopituitarism. PMID: 32304364 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - April 20, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Initial chest X-ray in multiple trauma patients: Still works!
CONCLUSION: All patients after high energy trauma with widened mediastinum together with obliteration of aortic arch and obliteration of aortopulmonary space on initial chest X-ray without initial CT, must be indicated to the CT after initial stop the bleeding procedures for the exclusion of traumatic rupture of thoracic aorta. PMID: 32304365 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - April 20, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Plasma Levels of Antioxidant Vitamins in Patients with Acromegaly: A Case-Control Study.
In this study, 100 cases, acromegaly patients of 57% (n=57, 29F, 28M, mean ages of 49.5±12.1) and control subjects of 43% (n=43, 29F, 14M, mean ages of 49.6±9.2). Acromegaly patients were classified into two groups; active acromegaly (AA; n=33) and controlled acromegaly (CA; n=24). RESULTS: Vitamin C levels were significantly lower in the acromegaly group [7.6 (4.7) mg/L, as median (IQR)] when compared to the control group [12.2 (5.5) mg/L, as median (IQR)] (p
Source: Neuroendocrinology Letters - April 20, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Evaluation of 5-hydroxyindoloacetic acid excretion in urine in patients with small intestine neuroendocrine neoplasm and carcinoid syndrome treated with somatostatin analogues.
Authors: Gut P, Ruchała M Abstract BACKGROUND: The assessment of hormonal function of neuroendocrine neoplasm (NEN) is an important stage in the diagnosis and monitoring of these diseases treatment. Objective of this study was to analyze the results of urinary excretion of 5-hydroxyindoloacetic acid (5-HIAA) in patients with carcinoid syndrome treated with somatostatin analogues, depending on the histologic maturity, degree of liver involvement and stage of the disease. METHODS: The final group comprised of 41 patients. All patients were subject to surgical removal of the primary site. Presence of hepatic meta...
Source: Neuroendocrinology Letters - April 20, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Intracranial pressure and mean arterial pressure monitoring in freely moving rats via telemetry; pilot study.
CONCLUSION: The results of the pilot study verified possibilities of long-term telemetric monitoring of the mean arterial and intracranial pressures for the determination of current cerebral perfusion pressure in freely moving rats under physiological conditions and with increased intracranial pressure due to the induced cerebral edema. Detailed analysis of the course of the curves in the experimental group revealed episodes of short-term CPP reduction below the optimum value of 70 mmHg. Interpretation of these episodes requires simultaneous monitoring of rat behavior. PMID: 32304368 [PubMed - as supplied by publisher]...
Source: Neuroendocrinology Letters - April 20, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The influence of meal frequency on lipid profile in the Polish population.
Authors: Tąpolska M, Spałek M, Skrypnik D, Bogdański P, Owecki M Abstract OBJECTIVES: Despite numerous investigations, the influence of meal frequency on the lipid profile has not been clearly determined. The aim of the study was to investigate whether meal frequency corresponds with the lipid profile. MATERIAL AND METHODS: The cross-sectional study enrolled 495 patients of University Hospital of Lord's Transfiguration who met inclusion criteria for study treated in 2015-2017. The subjects were divided according to meal frequency into a group consuming three or fewer meals a day and a group consuming fo...
Source: Neuroendocrinology Letters - April 20, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Combined Therapy for Patients after Ischemic Stroke as a Support of Social Adaptability.
CONCLUSION: The results of the research point to the fact, that combined therapy of robotic, psychomotor and cognitive can have positive effect on, and be suitable as a treatment for patients after ischemic stroke, regarding their productive age. Positive results have been therefore overt among all tested areas. PMID: 32304370 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - April 20, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Association of cognitive impairment and mood disorder with event-related potential P300 in patients with cerebral small vessel diseases.
Authors: Wang C, Gao J, Li M, Qi H, Zhao T, Zhang B, Zhou C, Fang S Abstract OBJECTIVE: Cerebral small vessel diseases (CSVDs) are common causes of cognitive impairments and mood disorders. In recent years, event-related potential P300 has received increasing attention as a biomarker of cognitive impairments or mood disorders. Previous studies on P300 mainly focused on anxiety, depression or cognitive impairments, and few results have been reported on P300 in CSVD patients. The present study aimed to explore the relationship between neuropsychological test scores and P300 in patients with CSVDs. METHODS: The cl...
Source: Neuroendocrinology Letters - April 20, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Cytotoxic brain edema induced by water intoxication and vasogenic brain edema induced by osmotic BBB disruption lead to distinct pattern of ICP elevation during telemetric monitoring in freely moving rats.
CONCLUSION: Our results indicate that purely experimental models of brain edema (WI, BBBd) without any parallel pathological process can compromise the basic brain homeostatic activity. PMID: 32200583 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 24, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Basal and metoclopramide induced prolactin secretion in lean PCOS women.
Authors: Abstract Polycystic ovary syndrome (PCOS) as well as hyperprolactinemia can cause infertility. In retrospective study the prolactin levels during the oral metoclopramide test among lean PCOS woman according to four phenotypes and free androgen index (FAI) were compared. The study population consisted of 314 lean PCOS women. The population was divided into four groups according to the FAI and menstrual cycle regularity. The group A consisted 126 women with FAI≥5 and irregular menstruation, the group B- 53 patients with FAI≥5 and regular menstruation. Group C- 70 patients with FAI
Source: Neuroendocrinology Letters - March 24, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Effect of diet and diet combined with chronic aerobic exercise on chemerin plasma concentrations and adipose tissue in obese women.
Authors: Abstract OBJECTIVE: Chemerin concentrations are elevated in obesity and associated with inflammation and insulin resistance. Exercise improves insulin sensitivity, which may be facilitated by changes in chemerin. We explored the effects of 24 -week aerobic exercise program, diet and both combined on serum and abdominal adipose tissue (AT) chemerin, and adiponectin concentrations in obese women. METHODS: Thirty volunteers participated in a 24-week intervention whereby the women were randomly categorised into three groups: 1) exercise (EX), 2) diet (DI) and 3) exercise and diet group (EXD). Blood sample...
Source: Neuroendocrinology Letters - March 24, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Severity of panic disorder, adverse events in childhood, dissociation, self-stigma and comorbid personality disorders Part 2: Therapeutic effectiveness of a combined cognitive behavioural therapy and pharmacotherapy in treatment-resistant inpatients.
CONCLUSIONS: Our prospective study discovers importance of the role of adverse childhood experiences, self-stigma, dissociation and comorbid personality disorder in effectiveness of combined cognitive-behavioural therapy and pharmacotherapy treatment in patients with treatment-resistant panic disorder. PMID: 32200586 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 24, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

A multidisciplinary approach to the management of  descending necrotizing mediastinitis - case series.
CONCLUSION: In management of descending necrotizing mediastinitis, early diagnosis, aggressive surgical treatment and use of broad-spectrum antibiotics and nowadays also multidisciplinary approach are crucial. Transcervical drainage combined with posterolateral thoracotomy or videothoracoscopy were used with good results. PMID: 32200587 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 24, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Neuropeptide Y knockdown in the dorsomedial hypothalamus improved basal and obesity-induced decrease in bone mass density.
CONCLUSION: Our data suggest that DMH NPY knockdown can alter bone metabolism. PMID: 32200588 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 24, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Genes regulating the hypothalamic-pituitary-gonadal axis and its impact on pubertal onset in mammals.
Authors: Ojha U, Nachiappan N Abstract Puberty in mammals is defined as the development of fertility, which involves the maturation of secondary sex characteristics and reproductive organs. This phenomenon is controlled by the Hypothalamic-Pituitary-Gonadal (HPG) axis. However, the timing of puberty differs greatly among individuals, and it is thought that a combination of genetic and environmental factors governs its onset. Advances in genetic analysis has allowed the identification of many more gene loci involved in regulating puberty. Understanding the genetics regulating the mammalian reproductive cycle can ope...
Source: Neuroendocrinology Letters - March 1, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Copeptin - a new diagnostic and prognostic biomarker in neurological and cardiovascular diseases.
Authors: Baranowska B, Kochanowski J Abstract Copeptin, arginine vasopressin (AVP)-associated 39 aminoacid glycopeptide, is a C-terminal part of pro-AVP. AVP acts through V1a, V1b, and V2 receptors. The effect on V1a receptors is connected with arterial vasoconstriction, on V2 with antidiuretic action, and on V1b with the secretion of ACTH, insulin, glucagon. Copeptin is found in the circulation in equimolar amounts with AVP. It is a very stable peptide and easy to estimate. Copeptin is a good diagnostic marker in many disorders in which vasopressinergic dysfunction plays a role in pathogenesis such as a polyu...
Source: Neuroendocrinology Letters - March 1, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Molecular biomarkers in the diagnostic of patients with colorectal cancer.
Authors: Fabišíková K, Behulová RL, Repiska V Abstract Colorectal cancer (CRC) is currently a well-known and studied issue in experimental research. Worldwide it is the third most common cancer in men and the second most common cancer in women. 70-80% of cases occur sporadically. Most CRCs develop from adenomas. The transition from normal epithelium to adenoma and finally into carcinoma is associated with acquired molecular events. In 5-10 % of cases, CRC develops from germline mutations in cancer-predisposing genes. 15% of patients have a family history of CRC that suggests a hereditary...
Source: Neuroendocrinology Letters - March 1, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Progressive Multifocal Leukoencephalopathy associated to treatment with natalizumab in Mexican patient Multiple Sclerosis. Case report, analysis and update.
Authors: Quiñones-Aguilar S, Sauri-Suárez S, Alcaraz-Estrada SL, García S Abstract One of the most dreaded complications in Multiple Sclerosis (MS) patients treated with natalizumab is the appearance of the Progressive Multifocal Leukoencephalopathy (PML). A 54-year-old Mexican woman diagnosed eight years before with MS, received natalizumab for the last three years. The patient developed PLM that was confirmed by clinical, radiological, blood and CSF tests. Her treatment included methylprednisolone, plasmapheresis, immunoglobulin and mirtazapine. Risks, causes, treatments, preventive measures ...
Source: Neuroendocrinology Letters - March 1, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Post-zygotic diploidization of triploidy in human is possible? - a case of triploid partial molar pregnancy resulting in a  premature live-born diploid female infant.
CONCLUSIONS: In clinical practice early diagnosis of this complication usually lead to pregnancy termination. In modern medicine, decisions should be based on evidence and patient-doctor mutual understanding. Termination of pregnancy with suspicion of molar placenta can be specially difficult in gestation in older nulliparous women or after ART. We sincerely hope that this report will be useful for physicians across the world in counseling and treating their patients. PMID: 32112547 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - March 1, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Severity of panic disorder, adverse events in childhood, dissociation, self-stigma and comorbid personality disorders Part 1: Relationships between clinical, psychosocial and demographic factors in pharmacoresistant panic disord.
Authors: Kolek A, Prasko J, Vanek J, Kantor K, Holubova M, Slepecky M, Nesnidal V, Latalova K, Ociskova M, Grambal A Abstract OBJECTIVES: Little is known about the relation between severity of panic disorder, adverse events in childhood, dissociation, self-stigma and comorbid personality disorders. The aim of this study is to look for the intercorrelations between these factors. METHOD: The study explores the relation between clinical, demographic and social factors in panic disorder using cross sectional design. The inpatients with pharmacoresistant panic disorder with and without agoraphobia were included in ...
Source: Neuroendocrinology Letters - March 1, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Diffuse Leptomeningeal Glioneuronal Tumor Presented with Language Developmental Delay.
We reported the case of a patient diagnosed with DLGNT who presented with language developmental delay and positive but subtle changes in imaging two years before the emergence of typical clinical symptoms. Few studies were conducted on early tumor symptoms due to the limited number of cases. We hypothesized that with the existence of pre-tumor symptoms, language developmental delay may be related to tumor. PMID: 32087090 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 23, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Acute Urinary Retention in Aseptic Meningitis: Meningitis-retention Syndrome.
Authors: Abstract Here we present the case of a 50-year-old woman with acute urinary retention who was treated by the insertion of a permanent catheter. For associated headaches, fever and muscle and joint pain, the patient underwent neurologic examination, including lumbar puncture and magnetic resonance of head and spine. The results confirmed aseptic meningitis. Subsequently, the patient was hospitalized at the infectious disease clinic, where the permanent catheter was extracted after 5 days, with spontaneous micturition recovery and no post-void residual volume. The combination of aseptic meningitis and urina...
Source: Neuroendocrinology Letters - February 23, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Growth hormone treatment in a patient with deletion of the long arm of chromosome 18: An 8-year observation.
CONCLUSIONS: This case indicates the need for early diagnosis and multidisciplinary action to achieve satisfactory quality of life in patients with 18q- syndrome. PMID: 32087092 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 23, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Non-functioning neuroendocrine pancreatic tumors transforming to malignant insulinomas - four cases and review of the literature.
CONCLUSIONS: Non-functional, metastatic Pan-NETs may transform to insulin secreting lesions, with negative impact on prognosis. Therefore, if symptoms as hypoglycemia develops continuous follow-up of clinical parameters, biochemical profiles of pancreatic hormones and histopathological evaluation of proliferation is suggested to detect changes in characteristics of these malignant neoplasms. PMID: 32087093 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 23, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Expression of Notch Receptors and Ligands in the Coccygeal Body.
CONCLUSIONS: Our observations suggest that Notch signaling may have relevant roles in glomus coccygeum function and biology. PMID: 32087094 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 23, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Small dense LDL - an important part of the atherogenic lipoprotein profile in individuals with impaired metabolism of lipoproteins. Comparison of two analytical procedures.
CONCLUSION: The concentration of sdLDL in plasma lipoprotein spectrum obtained by two different laboratory procedures was analysed, compared, evaluated and 70% identical corresponding results have been confirmed. PMID: 32087095 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - February 23, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Attachment of family to child with disability.
Authors: Veleminsky M, Veleminsky M, Fedor-Freybergh P, Witzanyová A, Šťastná I Abstract The development of attachment during the perinatal and/or postnatal periods between a child their mother, father and family as whole can be observed. This attachment provides the child with the safety and security feelings and may provide satisfaction to the mother and other family members. In children with physical and mental developmental disability, attachment may be challenged immediately after birth. It is typically recovered after a certain period. The authors describe the development of attachment o...
Source: Neuroendocrinology Letters - December 11, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Carotid Artery Stenosis after Radiation Therapy in a Patient with Lung Cancer: A Case Report and Literature Review.
We reported a case of carotid artery stenosis with stroke symptoms detected in a patient with lung cancer after radiotherapy. The patient was a 58-year-old male with a complaint of \"a single episode of temporary amaurosis in the right eye for 10 minutes". The clinical diagnosis at admission, after consideration of the patient's age, medical history, and auxiliary examination results, was as follows: lung cancer; right common carotid artery stenosis; left common carotid artery stenosis; left vertebral artery stenosis; and right subclavian artery occlusion with right subclavian steal syndrome (Grade 3). Carot...
Source: Neuroendocrinology Letters - December 11, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Internal consistency and factorial validity of the Slovak Version of the Young Schema Questionnaire - Short Form 3 (YSQ-S3).
CONCLUSION: In conclusion, the Slovak version of the YSQ-S3 is a psychometrically sound questionnaire that can be utilized for assessing EMS, both for research and clinical purposes. PMID: 31816218 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 11, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Meningitis and Ramsay-Hunt syndrome in a 17-year old girl.
CONCLUSIONS: A complete recovery of cranial nerves VII and VIII in the course of RHS can be achieved. PMID: 31816219 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 11, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Oxidative stress in patients with newly diagnosed multiple sclerosis: any association with subclinical atherosclerosis?
CONCLUSION: Our study showed decreased antioxidant capacity in newly diagnosed MS patients compared to controls. We failed to find association of subclinical atherosclerosis with oxidative stress in newly diagnosed MS. PMID: 31816220 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 11, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The efficacy of misoprostol in the first trimester miscarriage treatment - an individual patients' data analysis.
CONCLUSIONS: Pharmacological induction is an effective and safe treatment method of first trimester abortion in the majority of cases. The knowledge of factors influencing the efficacy of misoprostol may help clinicians in proper counselling and individualisation of therapy. PMID: 31816221 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 11, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Type 1 diabetes mellitus and the risk for schizophrenia or schizoaffective disorder: a Swedish nationwide register-based cohort study.
CONCLUSIONS: This study, in line with previous studies, shows that a diagnosis of T1DM is associated with a decreased risk of schizophrenia. This finding of an inverse association between T1DM and schizophrenia may bring an interesting piece, related to autoimmunity, into the schizophrenia-aetiology puzzle. PMID: 31816222 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 11, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Acute and chronic stress exert opposite effects on formation and contextualrelated fear conditioning in rats.
CONCLUSION: Our findings revealed acute and chronic stress led to distinct behavioral responses in fear conditioning and indicated CRFR1 is involved in the interaction of stress and fear conditioning, which help understand the connection between stress and fear memory. PMID: 31785211 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Risk of delayed diagnosis in young patients with left ventricular non-compaction - a potential benefit of magnetic resonance imaging.
CONCLUSIONS: The high variability of morphological findings and clinical manifestations of LVNC results in frequent overlooking of this disorder. Therefore, it is important to make the specialists more familiar with this condition and its pathology. Magnetic resonance imaging represents a conducive method to make correct diagnosis of LVNC under several specific conditions, particularly in case of non-conclusive echocardiographic finding. PMID: 31785212 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Effect of vitamin D deficiency on BMI in patients treated with Multi-acting Receptor Target Antipsychotics.
CONCLUSION: Vitamin D deficiency could be a risk factor for MARTA-induced weight gain. Further studies are necessary to replicate this finding. PMID: 31785213 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The clinical course and outcome of Listeria monocytogenes meningitis: A retrospective single center study.
Authors: Abstract BACKGROUND: The aim of the study was to determine clinical manifestations and outcome of Listeria monocytogenes meningitis (LM) and to compare with other forms of bacterial meningitis (BM). MATERIAL AND METHODS: We analyzed records of all adult patients with BM who were hospitalized between January 2010 and December 2017 in the largest neuroinfection center in Poland. RESULTS: Out of 343 analyzed patients with BM 24 were diagnosed to have LM. Patients with LM were older compared to patients with other forms of BM (62 years vs. 57 years, p=0.039), were more likely to have cancer (16.7% vs....
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome.
Authors: Abstract OBJECTIVES: Sleep apnea syndrome affects approximately 4% of adult males and 2% of adult females. It is associated with significant cardio-, cerebrovascular, metabolic and hormonal comorbidities and ranks among the more expensive medical specialties due to the requirement of high-quality technical diagnostic and therapeutic equipment as well as well-educated and experienced personnel. The aim of this study is to detect the relationship between C-reactive protein (CRP), pentraxin-3 (PTX-3), interleukin 6 (IL6), high-sensitivity troponin I (hsTnI), brain natriuretic protein (BNP) and galectin-3 ser...
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education.
Authors: Abstract PURPOSE: SIR proteins (silent information regulators, sirtuins, SIRT1 - SIRT7, SIR1 - SIR7) belong to NAD+-dependent deacetylases, enzymes taking part in a catalytic reaction of deacetylation, i.e. splitting the rest of acetic acid from protein substrates. Sirtuins play an important role in many cellular processes and are, therefore, involved in the ageing process and in the regulation of cell life. The aim of this paper is to verify the statistical hypothesis assuming the correlation between the age and level of education of examined persons and the expression of selected sirtuins (SIR1 - SIR7, ...
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Primary pituitary abscess case series and a review of the literature.
CONCLUSION: Presentation of fever, headache, diabetes insipidus, hypopituitarism and a sellar cystic mass with an enhanced rim after gadolinium contrast on pituitary magnetic resonance imaging may be suggestive of a pituitary abscess. Transsphenoidal endoscopic surgery, proper antibiotics and appropriate hormone replacement therapy when necessary are the keys of pituitary abscess treatment. PMID: 31785217 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Positive TgAbs in patients with Graves' orbitopathy are associated with lower risk of its active form - preliminary study.
Authors: Wojciechowska-Durczynska K, Zygmunt A, Matusiak A, Karbownik-Lewinska M, Lewinski A Abstract INTRODUCTION: In this retrospective, single-centre cohort study, we report our 10-year experience concerning clinical manifestation, diagnosis and treatment of Graves' orbitopathy (GO), with particular regard to antithyroid antibodies in iodine sufficient Polish population. MATERIALS AND METHODS: Data on thyrometabolic and immunological status of 71 patients diagnosed with GO, were collected. Also, we gathered information on the selection of the applied treatment in these cases of Graves' disease (GD): pharmaco...
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Selected topics in public health - Editorial.
Authors: Abstract In 2019, there were several new epidemics of diseases around the world, which would only be known from old medical books. Conspiracy and antivax movements around the world have raised important issues about public health, its safety, prevention and the media. The importance of public health is increasing more than ever. That is why we are very pleased that we have succeeded in collecting enough quality articles to present a collection of papers this year again. We have a great need for quality data to combat disinformation, hoaxes and lies. But we also have a greater need to deliver this informat...
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Anaphylaxis in Public Health.
Authors: Abstract The increasing number of patients with anaphylactic reactions is a modern challenge for healthcare professionals in clinical practice and public health professionals. It remains difficult to determine the prevalence or incidence of anaphylaxis in the population due to the long absence of a consensus definition, the fact that analyses are performed on various population groups and the use of different data collection methodologies. In the United States, anaphylaxis mortality ranges from 0.63 to 0.76 cases per million inhabitants, with 58% of these deaths due to drug anaphylaxis. The risk factors f...
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Suicides by ingestion of pure caffeine powder. New challenge for public health?
CONCLUSIONS: The presence of caffeine only at the concentration of 362 ug/mL in blood and 187 ug/mL in urine was revealed. The cause of death was cardiac arrest most likely due to ventricular dysrhythmia. The concentration of caffeine determined in the femoral blood of the decedent was three times higher than the lethal concentrations reported in other published case studies. Based on the investigated circumstances, the manner of death was evaluated as a suicide. PMID: 31785221 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research