CK19 is a sensitive marker for yolk sac tumours of the testis
Conclusion:
CK19 proved to be a sensitive marker to identify yolk sac tumours of the testis and to distinguish them from other germ cell tumours, especially seminomas and embryonic carcinomas.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4075546891400979. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - March 24, 2015 Category: Pathology Authors: Felix BremmerPhilipp StröbelHubertus JarryJasmin StreckerNadine GaisaArne StraußStefan SchweyerHeinz-Joachim RadzunCarl-Ludwig Behnes Source Type: research
Intratubular Large Cell Hyalinizing Sertoli Cell Tumor of the Testes in a 4-Year-Old Male With Peutz-Jeghers Syndrome
Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder that typically displays familial inheritance. Gastrointestinal polyposis and cutaneous pigmentation is a classic presentation of this syndrome. The reported lifetime cumulative cancer risk in PJS patients is >76% when compared with the general public with females affected more often than males. The prepubertal testicular tumor registry found Sertoli cell tumors (SCTs) to compose approximately 1% of all pediatric solid tumors. Prepubertal testicular masses are relatively rare. Only a small number of SCT cases have been reported in the first decade of life. T...
Source: Journal of Pediatric Hematology Oncology - March 23, 2015 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
Ovarian Paraganglioma
A rare case of ovarian paraganglioma was incidentally found as a 1.2-cm intraovarian mass in a 68-year-old hypertensive female operated for an endometrial carcinoma. Histologically, it was arranged in characteristic Zellballen composed of polygonal clear cells with a granular cytoplasm that expressed diffusely CAM5.2 cytokeratin, chromogranin, neuron-specific enolase, synaptophysin, and CD56, while S-100 protein was only present in sustentacular cells. We analyzed differential diagnoses with other rare ovarian tumors such as Sertoli cell tumor, with which it may share an immunophenotype expressing cytokeratins, S-100, and ...
Source: International Journal of Surgical Pathology - March 16, 2015 Category: Pathology Authors: Schuldt, M., Retamero, J. A., Tourne, M., Nogales, F. F. Tags: Case Reports Source Type: research
Mammalian gonocyte and spermatogonia differentiation: recent advances and remaining challenges.
Abstract
The production of spermatozoa relies on a pool of spermatogonial stem cells (SSCs), formed in infancy from the differentiation of their precursor cells, the gonocytes. Throughout adult life, SSCs will either self-renew or differentiate, in order to maintain a stem cell reserve while providing cells to the spermatogenic cycle. By contrast, gonocytes represent a transient and finite phase of development leading to the formation of SSCs or spermatogonia of the first spermatogenic wave. Gonocyte development involves phases of quiescence, cell proliferation, migration, and differentiation. Spermatogoni...
Source: Reproduction - February 15, 2015 Category: Reproduction Medicine Authors: Manku G, Culty M Tags: Reproduction Source Type: research
Mammalian gonocyte and spermatogonia differentiation: recent advances and remaining challenges
The production of spermatozoa relies on a pool of spermatogonial stem cells (SSCs), formed in infancy from the differentiation of their precursor cells, the gonocytes. Throughout adult life, SSCs will either self-renew or differentiate, in order to maintain a stem cell reserve while providing cells to the spermatogenic cycle. By contrast, gonocytes represent a transient and finite phase of development leading to the formation of SSCs or spermatogonia of the first spermatogenic wave. Gonocyte development involves phases of quiescence, cell proliferation, migration, and differentiation. Spermatogonia, on the other hand, rema...
Source: Reproduction - February 10, 2015 Category: Reproduction Medicine Authors: Manku, G., Culty, M. Tags: Reviews Source Type: research
