Familial syndromes associated with testicular and paratesticular neoplasms: a comprehensive review
AbstractA syndromic association between a subset of testicular/paratesticular neoplasms is well established. Such examples include Carney complex and large cell calcifying Sertoli cell tumor, Peutz-Jeghers syndrome and intratubular large cell hyalinizing Sertoli cell neoplasia, and VHL syndrome and clear cell papillary cystadenoma of the epididymis.However, recent studies proposed potential novel links between some testicular and paratesticular neoplasms with certain tumor syndromes. While more studies are still needed to solidify these associations, recent research suggests that a subset of Leydig cell tumors may arise in...
Source: Virchows Archiv - April 15, 2024 Category: Pathology Source Type: research
Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue
CONCLUSIONS.—: Our data provide a comprehensive overview on the patterns of StAR immunostaining in human tumors and suggest a diagnostic utility of StAR immunohistochemistry for supporting a diagnosis of Leydig cell tumors or of normal or neoplastic adrenocortical tissue.PMID:38484775 | DOI:10.5858/arpa.2023-0281-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 14, 2024 Category: Laboratory Medicine Authors: Maximilian Lennartz Daniela Amezada Doris H öflmayer Sebastian Dwertmann Rico Clara von Bargen Simon Kind Viktor Reiswich Florian Viehweger Florian Lutz Veit Bertram Christoph Fraune Natalia Gorbokon S ören Weidemann Claudia Hube-Magg Anne Menz Ria Uhli Source Type: research
Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue
CONCLUSIONS.—: Our data provide a comprehensive overview on the patterns of StAR immunostaining in human tumors and suggest a diagnostic utility of StAR immunohistochemistry for supporting a diagnosis of Leydig cell tumors or of normal or neoplastic adrenocortical tissue.PMID:38484775 | DOI:10.5858/arpa.2023-0281-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 14, 2024 Category: Laboratory Medicine Authors: Maximilian Lennartz Daniela Amezada Doris H öflmayer Sebastian Dwertmann Rico Clara von Bargen Simon Kind Viktor Reiswich Florian Viehweger Florian Lutz Veit Bertram Christoph Fraune Natalia Gorbokon S ören Weidemann Claudia Hube-Magg Anne Menz Ria Uhli Source Type: research
Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue
CONCLUSIONS.—: Our data provide a comprehensive overview on the patterns of StAR immunostaining in human tumors and suggest a diagnostic utility of StAR immunohistochemistry for supporting a diagnosis of Leydig cell tumors or of normal or neoplastic adrenocortical tissue.PMID:38484775 | DOI:10.5858/arpa.2023-0281-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 14, 2024 Category: Laboratory Medicine Authors: Maximilian Lennartz Daniela Amezada Doris H öflmayer Sebastian Dwertmann Rico Clara von Bargen Simon Kind Viktor Reiswich Florian Viehweger Florian Lutz Veit Bertram Christoph Fraune Natalia Gorbokon S ören Weidemann Claudia Hube-Magg Anne Menz Ria Uhli Source Type: research
Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue
CONCLUSIONS.—: Our data provide a comprehensive overview on the patterns of StAR immunostaining in human tumors and suggest a diagnostic utility of StAR immunohistochemistry for supporting a diagnosis of Leydig cell tumors or of normal or neoplastic adrenocortical tissue.PMID:38484775 | DOI:10.5858/arpa.2023-0281-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 14, 2024 Category: Laboratory Medicine Authors: Maximilian Lennartz Daniela Amezada Doris H öflmayer Sebastian Dwertmann Rico Clara von Bargen Simon Kind Viktor Reiswich Florian Viehweger Florian Lutz Veit Bertram Christoph Fraune Natalia Gorbokon S ören Weidemann Claudia Hube-Magg Anne Menz Ria Uhli Source Type: research
Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue
CONCLUSIONS.—: Our data provide a comprehensive overview on the patterns of StAR immunostaining in human tumors and suggest a diagnostic utility of StAR immunohistochemistry for supporting a diagnosis of Leydig cell tumors or of normal or neoplastic adrenocortical tissue.PMID:38484775 | DOI:10.5858/arpa.2023-0281-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 14, 2024 Category: Laboratory Medicine Authors: Maximilian Lennartz Daniela Amezada Doris H öflmayer Sebastian Dwertmann Rico Clara von Bargen Simon Kind Viktor Reiswich Florian Viehweger Florian Lutz Veit Bertram Christoph Fraune Natalia Gorbokon S ören Weidemann Claudia Hube-Magg Anne Menz Ria Uhli Source Type: research
Sertoli cell tumor in a 35-year-old woman – case report
Sertoli ‐Leydig cell tumors are very rare and account (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Tatiana Bujnowska, Irmina Buda, Ma łgorzata Reinholz-Jaskólska Source Type: research
Nitroproteomics is instrumental for stratification and targeted treatments of astrocytoma patients: expert recommendations for advanced 3PM approach with improved individual outcomes
AbstractProtein tyrosine nitration is a selectively and reversible important post-translational modification, which is closely related to oxidative stress. Astrocytoma is the most common neuroepithelial tumor with heterogeneity and complexity. In the past, the diagnosis of astrocytoma was based on the histological and clinical features, and the treatment methods were nothing more than surgery-assisted radiotherapy and chemotherapy. Obviously, traditional methods short falls an effective treatment for astrocytoma. In late 2021, the World Health Organization (WHO) adopted molecular biomarkers in the comprehensive diagnosis o...
Source: EPMA Journal - December 6, 2023 Category: International Medicine & Public Health Source Type: research
Effects of a Sertoli cell-specific knockout of Connexin43 on maturation and proliferation of postnatal Sertoli cells
In conclusion, deletion of the testicular gap junction protein Cx43 might prevent normal SC maturation and might even alter also the proliferation potential of adult SC.PMID:37839230 | DOI:10.1016/j.diff.2023.09.002 (Source: Differentiation)
Source: Differentiation - October 15, 2023 Category: Research Authors: Hanna H üneke Marion Langeheine Kristina Rode Klaus Jung Adrian Pilatz Daniela Fietz Sabine Kliesch Ralph Brehm Source Type: research
Effects of a Sertoli cell-specific knockout of Connexin43 on maturation and proliferation of postnatal Sertoli cells
In conclusion, deletion of the testicular gap junction protein Cx43 might prevent normal SC maturation and might even alter also the proliferation potential of adult SC.PMID:37839230 | DOI:10.1016/j.diff.2023.09.002 (Source: Differentiation)
Source: Differentiation - October 15, 2023 Category: Research Authors: Hanna H üneke Marion Langeheine Kristina Rode Klaus Jung Adrian Pilatz Daniela Fietz Sabine Kliesch Ralph Brehm Source Type: research
Effects of a Sertoli cell-specific knockout of Connexin43 on maturation and proliferation of postnatal Sertoli cells
In conclusion, deletion of the testicular gap junction protein Cx43 might prevent normal SC maturation and might even alter also the proliferation potential of adult SC.PMID:37839230 | DOI:10.1016/j.diff.2023.09.002 (Source: Differentiation)
Source: Differentiation - October 15, 2023 Category: Research Authors: Hanna H üneke Marion Langeheine Kristina Rode Klaus Jung Adrian Pilatz Daniela Fietz Sabine Kliesch Ralph Brehm Source Type: research
Effects of a Sertoli cell-specific knockout of Connexin43 on maturation and proliferation of postnatal Sertoli cells
In conclusion, deletion of the testicular gap junction protein Cx43 might prevent normal SC maturation and might even alter also the proliferation potential of adult SC.PMID:37839230 | DOI:10.1016/j.diff.2023.09.002 (Source: Differentiation)
Source: Differentiation - October 15, 2023 Category: Research Authors: Hanna H üneke Marion Langeheine Kristina Rode Klaus Jung Adrian Pilatz Daniela Fietz Sabine Kliesch Ralph Brehm Source Type: research
Single-cell RNA sequencing technology in human spermatogenesis: Progresses and perspectives
Mol Cell Biochem. 2023 Sep 2. doi: 10.1007/s11010-023-04840-x. Online ahead of print.ABSTRACTSpermatogenesis, a key part of the spermiation process, is regulated by a combination of key cells, such as primordial germ cells, spermatogonial stem cells, and somatic cells, such as Sertoli cells. Abnormal spermatogenesis can lead to azoospermia, testicular tumors, and other diseases related to male infertility. The application of single-cell RNA sequencing (scRNA-seq) technology in male reproduction is gradually increasing with its unique insight into deep mining and analysis. The data cover different periods of neonatal, prepu...
Source: Molecular and Cellular Biochemistry - September 2, 2023 Category: Biochemistry Authors: Hanbo Jia Wei Wang Zhaowen Zhou Zhiyi Chen Zijun Lan Hao Bo Liqing Fan Source Type: research
Single-cell RNA sequencing technology in human spermatogenesis: Progresses and perspectives
Mol Cell Biochem. 2023 Sep 2. doi: 10.1007/s11010-023-04840-x. Online ahead of print.ABSTRACTSpermatogenesis, a key part of the spermiation process, is regulated by a combination of key cells, such as primordial germ cells, spermatogonial stem cells, and somatic cells, such as Sertoli cells. Abnormal spermatogenesis can lead to azoospermia, testicular tumors, and other diseases related to male infertility. The application of single-cell RNA sequencing (scRNA-seq) technology in male reproduction is gradually increasing with its unique insight into deep mining and analysis. The data cover different periods of neonatal, prepu...
Source: Molecular and Cellular Biochemistry - September 2, 2023 Category: Biochemistry Authors: Hanbo Jia Wei Wang Zhaowen Zhou Zhiyi Chen Zijun Lan Hao Bo Liqing Fan Source Type: research
Single-cell RNA sequencing technology in human spermatogenesis: Progresses and perspectives
Mol Cell Biochem. 2023 Sep 2. doi: 10.1007/s11010-023-04840-x. Online ahead of print.ABSTRACTSpermatogenesis, a key part of the spermiation process, is regulated by a combination of key cells, such as primordial germ cells, spermatogonial stem cells, and somatic cells, such as Sertoli cells. Abnormal spermatogenesis can lead to azoospermia, testicular tumors, and other diseases related to male infertility. The application of single-cell RNA sequencing (scRNA-seq) technology in male reproduction is gradually increasing with its unique insight into deep mining and analysis. The data cover different periods of neonatal, prepu...
Source: Molecular and Cellular Biochemistry - September 2, 2023 Category: Biochemistry Authors: Hanbo Jia Wei Wang Zhaowen Zhou Zhiyi Chen Zijun Lan Hao Bo Liqing Fan Source Type: research
