The Emergence of Non-communicable Disease in Indonesia.
Authors: Purnamasari D Abstract Based on data from the Indonesian Ministry of Health Information Center, the estimated population of Indonesia in 2016 was approximately 258,704,986 people, consisted of 129,988,690 men and 128,716,296 women. This number of Indonesian population represents young population since the proportion of population aged 0-14 years is more than that aged>14 years. Meanwhile, the proportion of population aged 50 years and above is significantly reduced, which is thought to be due to high mortality rate in the middle-aged population. The mortality rate in  Indonesia is dominated by non-...
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Comparison of Survival Prediction with Single versus Combination Use of Microcirculation End Point Resuscitation in Sepsis and Septic Shock.
CONCLUSION: in patients with sepsis and septic shock, achievement of lactate clearance and ScvO2 targets associates with similar early mortality risk compared to achievement of lactate clearance target only. However, it associates with lower early mortality risk compared with ScvO2 target only. PMID: 30630991 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Kidney Disease Profiles Among Adolescents In Indonesia.
CONCLUSION: The proportion of prehypertension and hypertension in adolescents aged 15-18 years in Indonesia is high. Hence, routine blood pressure measurement is important for early detection and prevention of kidney disease progression. PMID: 30630992 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Non-Small Cell Lung Carcinoma in Women: A Retrospective Cohort Study in Indonesia.
This study aimed to know characteristics and survival of female patients with non-small-cell lung carcinoma (NSCLC) in Dharmais National Cancer Centre Hospital. METHODS: a retrospective cohort study was performed among NSCLC female patients in Dharmais Cancer Hospital (DCH) between January 2005 and December 2015. Survival analysis was done using the Kaplan-Meir estimation curve with proportional assumption test. Independent prognostic factors were analyzed using the Cox proportional hazard model with a hazard ratio (HR) and its 95% confidence interval (CI). RESULTS: a total of 956 NSCLC cases were retrieved during ...
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Exercise Intervention for Chronic Pain Management, Muscle Strengthening, and Functional Score in Obese Patients with Chronic Musculoskeletal Pain: A Systematic Review and Meta-analysis.
CONCLUSION: exercise can improve physical function objectively, but could not reduce pain in obese patients with chronic musculoskeletal problem subjectively. PMID: 30630994 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Association Between Parents History of Type 2 Diabetes with Metabolic Syndrome Component and Insulin Resistance in Non-Diabetic Young Adult Male.
CONCLUSION: the early multiple metabolic defect can be detected in non-diabetes adolescents with parental history of type-2 diabetes. Cluster of metabolic syndrome component in these subject become  a powerful determinat factor for insulin resistance. PMID: 30630995 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Association between A1166C Polymorphism of the Angiotensin II Type-1 Receptor Gene and Type-2 Diabetic Nephropathy in an Indonesian Malay Population.
CONCLUSION: there was positive association between A1166C AT1R polymorphism and susceptibility of type-2 diabetics to DN in Malay Indonesian Population. It also indicated that the A1166C AT1R polymorphism could play a role in early pathogenesis of DN. PMID: 30630996 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Association of Periodontitis and Arterial Stiffness in Type 2 Diabetic Patients.
CONCLUSION: most of type-2 diabetics had severe periodontitis; however, the correlation between periodontitis and arterial stiffness could not be concluded in this study. PMID: 30630997 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Hypertension Despite Dehydration in an Adolescent with Diabetic Ketoacidosis.
Authors: Onyiriuka AN, Monday P, Oguejiofor CA Abstract In general, information on blood pressure changes in diabetic ketoacidosis in paediatric population is very scarce. Our aim was to report a case of severe DKA in an adolescent girl who unexpectedly had hypertension rather than hypotension.A 17-year-old girl presented in our Children's Emergency Unit with complaints of excessive eating for 6 weeks, excessive urination for 2 weeks, fever for 1 week, vomiting for 4 days, difficulty with breathing for one day and unresponsiveness to calls for 3 hours. She had moderated to severe dehydration but no hypotension. Lab...
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Acute Appendicitis in a Patient with Systemic Lupus Erythematosus.
Authors: Gunawan H, Awalia A, Soeroso J Abstract Systemic lupus erythematosus (SLE) is a chronic excacerbative autoimmune disease with wide clinical spectrum. Gastrointestinal manifestasion is a frequent clinical manifestasion seen in SLE. Management with glucocorticoid and non-steroid anti-inflammatory drugs (NSAID) can mask the gastrointestinal symptoms in patient with SLE. One of the etiologies of gastrointestinal manifestations in SLE is acute appendicitis. Patients with acute appendicitis usually have abdominal pain as its chief complaint. The pathophysiology of acute appendicitis can occur primarily from SLE ...
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Insulin Resistance in Gastroesophageal Reflux Disease.
Authors: Budiyani L, Purnamasari D, Simadibrata M, Abdullah M Abstract Insulin resistance is the disturbance of glucose regulation characterized by higher insulin level. In clinical context, insulin resistance can manifest as abnormalities that are related with cardiovascular event risk, known as metabolic syndrome. Several studies had reported that insulin resistance was associated with erosive esophagitis in patients with gastroesophageal reflux disease (GERD). PMID: 30631000 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Cerebral Venous Sinus Thrombosis in Systemic Lupus Erythematosus.
Authors: Darmawan G, Hamijoyo L, Oehadian A, Bandiara R, Amalia L Abstract A 38-year-old woman presented with general weakness and vaginal bleeding. One month prior, she had been diagnosed with Evans syndrome (haemolytic anemia with positive Coombs test and thrombocytopenia) and was given oral steroid as maintenance therapy. Her serology examination was negative for hepatitis B, hepatitis C, and human immunodeficiency virus (HIV). Her obstetrical history was marked by miscarriage in second pregnancy and preeclampsia in third pregnancy. She used hormonal contraceptives until 5 months prior to admission. On physical ...
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Radiofrequency Ablation versus Resection in Large Single Nodule of Hepatocellular Carcinoma: an Evidence-based Case Report.
CONCLUSION: all studies used RFA as the alternative of resection when the the tumor was irresectable which means the severity is higher in RFA group. Hence, we can not solely conclude that RFA resulted in worse survival. PMID: 30631002 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Current Practice of Hepatocellular Carcinoma Surveillance.
Authors: Loho IM, Siregar L, Waspodo AS, Hasan I Abstract Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. This is due to the heterogeneity of the tumor biology and lack of curative treatment options. The most significant prognostic factor is detection at early stage and thus, surveillance strategies are of high importance. High-risk patients should undergo ultrasound and tumor marker tests at six-month interval in order to detect HCC at the earlier stage. However, in real-life practice, ultrasound has several limitations and the adherence to HCC surveillance is subo...
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Early Detection of Plasma Leakage in Dengue Hemorrhagic Fever.
Authors: Nelwan EJ Abstract Dengue viral infection remains a major public health problem. As many as 400 million people are infected yearly. Even though the vaccine is available, the use of dengue vaccine is still limited due to some concerns. Among patient infected with dengue viral infection, early recognition of the virus and prompt supportive treatment are important to avoid complication and mortality.The clinical spectrum of dengue viral infection is diverse ranging from undifferentiated fever to dengue shock syndrome characterized by plasma leak and hemoconcentration. No specific antiviral therapy is availabl...
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Diagnostic Accuracy of Platelet/Lymphocyte Ratio for Screening Complex Coronary Lesion in Different Age Group of Patients with Acute Coronary Syndrome.
CONCLUSION: the optimum cut-off point for PLR in patients aged ≤ 45 years is 111.06 and for patients with age>45 years is 104.78 with diagnostic accuracy, represented by AUC of 93.9% (p
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Gallbladder Wall Thickening for Early Detection of Plasma Leakage in Dengue Infected Adult Patients.
CONCLUSION: gallbladder wall thickening in the early phase of the disease can be used to detect the occurrence of plasma leakage in adult dengue infected patients. PMID: 30333268 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Efficacy of Additional Solifenacin Succinate Therapy for Storage Symptoms in Females with Uncomplicated Lower Urinary Tract Infection: The SOLUTION Randomized Controlled Trial.
This study aimed to evaluate whether additional anticholinergic is beneficial alongside an empiric antibiotic therapy in reducing symptoms and tolerable for females with uncomplicated UTI. METHODS: this was a randomized double-blind controlled trial that included female aged>18 y.o with uncomplicated lower UTI. Patients were randomly assigned to either solifenacin succinate 5 mg (group 1) or placebo (group 2) in addition to empiric levofloxacin 500 mg treatment for 3 days. Those with structural and/or functional abnormalities of the urinary tract and allergic reaction history were excluded. We observed changes in ov...
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

A Clinical Trial on Biological Half Life of Bioactive Protein from Lumbricus rubellus, DLBS1033 in Healthy Volunteers.
CONCLUSION: it is concluded that the fibrinolytic effects of DLBS1033 can be measured in steady state condition. The biological half-life of DLBS1033 in steady state condition was 8.6 hours. There were no serious adverse events on two groups of subjects. PMID: 30333270 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Effect of Alfacalcidol on Inflammatory markers and T Cell Subsets in Elderly with Frailty Syndrome: a Double Blind Randomized Controlled Trial.
This study aimed to determine the effect of alphacalcidol on inflammatory cytokines (IL-6, IL-10, g-IFN ) and T cell subsets (CD4/CD8 ratio and CD8+ CD28-) of elderly with various stages of frailty syndrome. METHODS: from January to July 2017, a double blind randomized controlled trial (RCT) with allocation concealment, involving 110 elderly subjects from Geriatric Outpatient Clinic Cipto Mangunkusumo Hospital Jakarta, was conducted to measure the effect of 0.5 mcg alphacalcidol administration for 90 days to inflammatory cytokines (IL-6, IL-10, g-IFN) from PBMC culture supernatant, as well as CD4/CD8 and CD8+CD28- perc...
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Comparison of Quality of Life between Patients Undergoing Chronic Hemodialysis with Reusable Dialyzer and Single-Use Dialyzer: A Retrospective Cohort Study.
CONCLUSION: the reusable dialyzer membrane lowers the ESRD patients' quality of life influenced by another factor such as low income. PMID: 30333272 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Evaluation of Iron Overload Between Age Groups Using Magnetic Resonance Imaging and Its Correlation with Iron Profile in Transfusion-dependent Thalassemia.
CONCLUSION: cardiac and hepatic iron deposition between children and adults differ significantly. Liver has the greatest iron overload, followed by pancreas and heart. Iron deposition in liver and pancreas has been started from earlier age. Pancreatic iron deposition rises with increasing age. Serum ferritin and transferrin saturation should not be used solely to predict iron overload in various organs. We suggest that MRI evaluation must be conducted at least once to assess iron deposition in organs. PMID: 30333273 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Intravenous Rituximab in Severe Refractory Primary Focal Segmental Glomerulosclerosis.
Authors: Wee Leng G, Mustafar R, Kamaruzaman L, Mohd R, Cader RA, Wei Yen K, Kiew Bing P Abstract Managing primary or even secondary glomerulonephritis remains a challenge to many nephrologists. In primary focal segmental glomerulosclerosis (FSGS) with heavy proteinuria, renin aldosterone system blockade and high dose of oral prednisolone is the mainstay of treatment. Other immunosuppressive medications like Cyclophosphamide, Cyclosporine A and Mycophenolate Mofetil (MMF) are warranted if a complete remission is not achieved.  We illustrate a case of 21 year old gentleman with primary FSGS that was difficult t...
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Catheter-related Blood Stream Infection in a Patient with Hemodialysis.
Authors: Dharmayanti A, Astrawinata D Abstract A 31-year-old patient came to visit the outpatient clinic at the hospital for his routine twice-weekly hemodialyis (HD) session. During HD, the patient suddenly developed a fever with shivering. At that time, a diagnosis of catheter-related blood stream infection (CR-BSI) was developed, HD catheter or the catheter double lumen (CDL) was uninstalled and the patient was hospitalized. Results of culture withdrawn through the tip of catheter lumen and peripheral blood revealed identical microorganism, i.e. the Enterobacter cloacae. Diagnosis of CR-BSI in the present case w...
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Effect of Uric Acid on Blood Glucose Levels.
Authors: Wardhana W, Rudijanto A Abstract Uric acid as the final result of purine bases metabolism. In high level condition, uric acid enters the cell and act as oxidant, and acts as independent risk factor and predicts the incident of type 2 diabetes mellitus (T2DM). It may directly inactivate or through oxidative reaction that lower the nitric oxide (NO) level. Lower NO level will reduce insulin uptake in tissues and reduce in GLUT4 translocation in cell that will effect the blood glucose level. The High level of uric acid or hyperuricemia makes oxidative stress by inducing the production of reactive oxygen speci...
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

An Interesting Case of Hepatic Adrenocortical Carcinoma.
We report an interesting case of hepatic ACC in a young woman with clinical signs of virilization.A-21-year old Sundanese woman visited our endocrine clinic with progressive hirsutism over the face, body, and extremities starting 14 years previously. She had irregular, heavy periods when she was 7 years old. She also experienced pubertal development of her breasts. However, both menstrual cycle and breast development ceased when she was 8 years old. She noticed voice deepening and alopecia. Physical examination showed male-type alopecia and intense hirsutism. Tanner stage was 3 for breast tissue and 5 for pubic hair. There...
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Plant-based Diet for HbA1c Reduction in Type 2 Diabetes Mellitus: an Evidence-based Case Report.
CONCLUSION: in patients with type 2 diabetes mellitus, HbA1c reduction was greater in patients with plant-based diet compared to patients with conventional diet. Further research should be conducted with larger sample size and longer follow-up period. PMID: 30333278 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Adult Diphtheria Vaccination.
Authors: Rengganis I Abstract Low adult vaccination coverage in Indonesia may contribute to a recent outbreak of diphtheria in Indonesia. Although well known as a pediatric vaccine, diphtheria vaccination should be administered as booster to adolescence and adults for longer prevention. Adult vaccine differs from pediatric vaccine but have similar protection. Additionally, there is special recommendation to vaccinate pregnant women and elderly people aged 65 years or more. PMID: 30333279 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - October 21, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Role of Reed-Sternberg CD30 Receptor and Lymphocytes in Pathogenesis of Disease and Its Implication for Treatment.
Authors: Rinaldi I Abstract Hodgkin lymphoma is a cancer that can be cured using standard chemotherapy with or without radiation. Although it accounts for only 0.6% of all malignancy worldwide, but it usually affects young adults with median age of 38 years. About 60 to 90% cases can be cured depending on its stage and 5 to 10% cases are refractory to the first-line chemotherapy; while 20 to 30% patients experiencing relapse after receiving the first-line chemotherapy. The relapse causes new problem in treatment. A monoclonal antibody-chemotherapy conjugate, Brentuximab vedotin, was approved by Food Drug Associatio...
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Cardiovascular Disease Risk Factors Among Blue and White-collar Workers in Indonesia.
Authors: Prihartono NA, Fitriyani F, Riyadina W Abstract BACKGROUND: cardiovascular diseases (CVD) is the most common cause of death in Indonesia. We aimed to examine risks of CVD in workers aged 40 to 69 year related to their occupational status. METHODS: a cross-sectional study in all provinces of Indonesia. Data from a large-scale national health survey called RISKESDAS were used to analyze factors associated with CVD. Analysis was restricted to the working population aged 40 to 69 year. There were 137,378 subjects included in the analysis. Cox's regression analysis was modified to calculate prevalence ratio...
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

CD30, CD15, CD50, and PAX5 Expressions as Diagnostic Markers for Hodgkin Lymphoma (HL) and Systemic Anaplastic Large Cell Lymphoma (sALCL).
CONCLUSION: present study shows that almost 90% patients have positive CD30 expression;  while the positive expressions of CD15, CD50, and PAX5 are found in less than 40% patients. It indicates that CD30 is an important diagnostic marker for HL and sALCL and it may improve treatment strategy. PMID: 29950528 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Diagnostic Determinants of Proliferative Lupus Nephritis Based on Clinical and Laboratory Parameters: A Diagnostic Study.
This study aimed to develop a diagnostic scoring system of proliferative LN based on its diagnostic determinants including hypertension, proteinuria, hematuria, eGFR, anti-dsDNA antibody, and C3 levels. METHODS: a cross-sectional study with total sampling method was conducted. Our subjects were adult LN patients who underwent renal biopsy in Cipto Mangunkusumo Hospital between January 2007 and June 2017. RESULTS: from a total of 191 subjects with biopsy-proven LN in this study, we found a proportion of proliferative LN of 74.8%. There were 113 subjects included for analysis of proliferative LN determinants. The mul...
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

7 Years Experience of Living Donor Kidney Transplantation in Indonesia: A Retrospective Cohort Study.
CONCLUSION: the 1-year graft and patient survival rate were 92% and 87%. The 3-year graft and patient survival rate were 90.6% and 79.7%. Only small percentage of donor were family-related. Living donor recruitment and evaluation are still a big challenge in Indonesia. PMID: 29950530 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Comparison of Specific Immunoglobulin E with the Skin Prick Test in the Diagnosis of House Dust Mites and Cockroach Sensitization in Patients with Asthma and/or Allergic Rhinitis.
CONCLUSION: serum specific IgE testing to common inhalant allergen in patients with respiratory allergy showed only low-to-moderate sensitivity, but high specificity and PPV. This new assay can be used to diagnose allergen sensitization in the population with high prevalence of TDR and cockroach. PMID: 29950531 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Correlation Between Vitreous Advanced Glycation End Products, and D-dimer with Blood HbA1c Levels in Proliferative Diabetic Retinopathy.
This study aimed to find the association between blood HbA1c levels with vitreous AGEs and D-dimer levels in patients with proliferative DR. METHODS: an analytical cross-sectional study was performed in subjects with proliferative DR who underwent vitrectomy. Subjects were divided into 2 subgroups, i.e. uncontrolled (HbA1c>7%) and controlled (HbA1c
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Benefit of Interferon-Gamma Release Assay for Diagnosis of Extrapulmonary Tuberculosis.
CONCLUSION: IGRA could be used as supporting tool in the diagnosis of extrapulmonary TB. The negative result, however, does not indicate absence of TB infection. PMID: 29950533 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Coexistence of Systemic Lupus Erythematosus and Psoriasis: Is It Possible?
We reported two cases of SLE with psoriasis vulgaris with clinical manifestations as recurrent erythroderma with photosensitivity. Improvement in clinical condition was observed after treating the patients with methylprednisolone combined with methotrexate. The coexistence SLE and psoriasis are considered very rare. The presence of this overlap syndrome may precede one another or occur simultaneously and is closely related with the presence of anti-Ro/SSA. Thus, it raises new challenge regarding its relationships, diagnosis, therapeutic, and management. PMID: 29950534 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

A Chronic Lymphocytic Leukemia Patient with Progressive Multifocal Leukoencephalopathy Caused by John Cunningham Virus.
We present a case of a 67-year-old woman who suffered from CLL with a chief complaint of seizure. Her clinical symptoms, results of brain MRI and biopsy were suggestive for the JCV-induced PML. The patient had received treatment using mefloquine at dose of 250 mg/day with no clinical improvement. PMID: 29950535 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Obesity as the Sequel of Childhood Stunting: Ghrelin and GHSR Gene Polymorphism Explained.
Authors: Muhammad HFL Abstract Stunting or short stature in children is a significant nutritional problem in developing and underdeveloped countries. Stunting during childhood might affect brain development and impair development cognitive function. Additionally, this condition associated with the increased risk for obesity during adulthood. Several studies have shown that the increment risk of obesity and overweight in children with a short stature was due to their metabolic efficiency. Children with stunting have lower resting energy expenditure compared to non stunting children. Additionally, stunted children ha...
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Double Culprits in a Patient with ST Elevation Myocardial Infarction: A Challenging But Rewarding Case.
Authors: Ginanjar E, Yulianto Y, Salim S, Setyawan W Abstract Myocardial infarction simultaneously involving two or more culprit lesions is extremely rare and usually has a poor clinical outcomes including mortality. Management of this complicated condition is challenging and limited time. Nevertheless, autopsy studies revealed that thrombotic occlusion of more than one major epicardium coronary artery is not uncommon. A 68-year-old woman presented with sudden onset of limited breath and chest discomfort since two hours prior to admission. She also felt exert dyspnoea since one month ago. She has two risk factors t...
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Comparison of Deferiprone to Deferasirox and Deferoxamine to Cardiac and Hepatic T2* MRI in Thalassemia Patients: Evidence-based Case Report.
CONCLUSION: DFP is superior in controlling or reducing myocardial iron load (as proven by mT2* MRI) and DFO had better capabilities in controlling or reducing hepatic iron load (as proven by liver T2* MRI). Studies with longer observation and larger samples is needed to see a significant changes of T2* MRI in DFX. PMID: 29950538 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Current Diagnosis and Management of Graves' Disease.
This article highlights clinical points to treat Grave's disease patients from reviews and latest guidelines from American Thyroid Association (ATA), European Thyroid Association (ETA), and Japan Thyroid Association/ Japan Endocrine Society. PMID: 29950539 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - June 30, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Risk Factors for Multidrug-resistant Tuberculosis.
Authors: Rumende CM Abstract In 2015, 10.4 million people developed tuberculosis (TB) and 580,000 amongst them suffered from multidrug-resistant TB (MDR-TB). From those 580,000 cases of MDR-TB, only 125,000 were detected and reported. A total of 111,000 people began to receive MDR-TB treatment in 2014 while 190,000 MDR-TB patients were estimated to have died, largely due to lack of access to effective treatment. The mechanism of drug resistance can be caused by genetic factors, factors related to previous treatment and other factors such as comorbidity with diabetes mellitus. Although there is some evidence which p...
Source: Acta medica Indonesiana - April 25, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Adaptation of the Tool to Estimate Patient Costs Questionnaire into Indonesian Context for Tuberculosis-affected Households.
CONCLUSION: the adapted Tool to Estimate Patient Costs in Bahasa Indonesia is comprehensive and ready for use in future studies on TB-related catastrophic costs and is suitable for monitoring progress to achieve the target of the End TB Strategy. PMID: 29686170 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - April 25, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Influence of Diabetes Mellitus on the Development of Multi Drug Resistant-Tuberculosis in Yogyakarta.
CONCLUSION: there was a significant correlation between diabetes mellitus and MDR-TB development. Therefore, it is suggested that clinicians at all levels of health care service should conduct any kind of screening test for MDR-TB in such group of patients. Further prospective cohort study is needed to confirm the findings of this preliminary study. PMID: 29686171 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - April 25, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Meta-analysis of Optimal Management of Lower Pole Stone of 10 - 20 mm: Flexible Ureteroscopy (FURS) versus Extracorporeal Shock Wave Lithotripsy (ESWL) versus Percutaneus Nephrolithotomy (PCNL).
Authors: Yuri P, Hariwibowo R, Soeroharjo I, Danarto R, Hendri AZ, Brodjonegoro SR, Rasyid N, Birowo P, Widyahening IS Abstract BACKGROUND: the optimal management of lower calyceal stones is still controversial, because no single method is suitable for the removal of all lower calyceal stones. Minimally invasive procedures such as extracorporeal shock wave lithotripsy (ESWL), percutaneous nephrolithotomy (PCNL) and flexible ureteroscopy (fURS) are the therapeutic methods for lower calyceal stones. The aim of this study was to identify the optimal management of 10-20 mm lower pole stones. METHODS: a meta-analysi...
Source: Acta medica Indonesiana - April 25, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Indonesia Cohort of IO HAT Study to Evaluate Diabetes Management, Control, and Complications in Retrospective and Prospective Periods Among Insulin-Treated Patients with Type 1 and Type 2 Diabetes.
CONCLUSION: overall, high proportion of patients reported hypoglycemic events in the prospective period indicating under reporting during the retrospective period due to recall bias. Therefore, there is a need for patient education program to improve the awareness of hypoglycemia in diabetes patient in Indonesia. PMID: 29686173 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - April 25, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Analyzing Determinant Factors for Pathophysiology of Functional Dyspepsia Based on Plasma Cortisol Levels, IL-6 and IL-8 Expressions and H. pylori Activity.
CONCLUSION: many factors can become the determinant factors for gastric mucosal damage; however, our study has demonstrated that the dominant factor is afternoon plasma cortisol levels. PMID: 29686174 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - April 25, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Diabetic Ketoacidosis in Adolescents and Children: A Prospective Study of Blood versus Urine Ketones in Monitoring Therapeutic Response.
CONCLUSION: blood ketone concentration showed better correlation with pH and bicarbonate level, as a tool to monitor therapeutic response in DKA in adolescent, compared to traditional urine ketones test in adolescents. PMID: 29686175 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - April 25, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Association Between Arg753Gln and Arg677Trp Polymorphisms of TLR2 Gene with Active Pulmonary Tuberculosis in an Indonesian Population.
Authors: Soeroto AY, Dahlan Z, Kartasasmita CB, Parwati I Abstract BACKGROUND: Toll-like receptor is a pattern recognition receptor (PRR) that recognize pathogen-associated molecular pattern (PAMP) in a microorganism. Macrophages recognize the presence of mycobacteria through Toll-Like Receptor 2 (TLR2) and signaling further lead to the production of cytokines, both proinflammatory TNF-α, IL-1β, IL-6, IL-12, IL-15, IL-18 and IFN-γ, as well as anti-inflammatory IL4, IL-10 and TGF-β. TLR2 gene polymorphism is strongly determined by ethnicity and geography. Therefore it is necessary to uncovered ...
Source: Acta medica Indonesiana - April 25, 2018 Category: Internal Medicine Tags: Acta Med Indones Source Type: research