A Call for Preventive Medicine Attention for Indonesian Physicians.
Authors: Pramono LA Abstract The year of 2020 teaches us to prevent is always better than to cure. It is an old phrase that is being used for decades, but it is never been implemented cordially by our society nowadays. Covid-19 is a good lesson that reminds us to carefully prevent the spread of coronavirus which is now a pandemic worldwide. People now wash their hands more often and clean, wear a mask everywhere - everytime, do physical distancing, do healthy lifestyle such as physical activity, healthy diet, and consume multivitamins. They obey the cough and sneeze etiquette. Prevention awareness is never been suc...
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Role of Acute Hyperglycemia on the Risk of Malignant Arrhythmia in Acute Myocardial Infarction Patients: A Study of Myocardial Damage, Ion Channel Changes and Inflammatory Factors.
CONCLUSION: it was concluded that the inititial stage of AMI causes more dominant myocardial damage, as compared to metabolic factors. In the next stage of AMI, acute hyperglycemia increases ROS and the activation of ion channel changes described by CaMKII. This change results in electrophysiological remodeling of the heart, as seen in the VLP image on SA-ECG. PMID: 32778623 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Poor Physical Function as a Risk Factor for Non-Communicable Diseases in Indonesia: A Retrospective Cohort Study.
CONCLUSION: poor physical function can be assessed to identify risk of diabetes, heart disease, and stroke. Healthcare personnel should provide education programs that inform patients on the importance of maintaining a healthy physical ability. PMID: 32778624 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Influence of Micronutrient Consumption by Tuberculosis Patients on the Sputum Conversion Rate: A Systematic Review and Meta-analysis Study.
CONCLUSION: micronutrient intervention during tuberculosis treatment has a positive effect toward to sputum conversion among patient. Zinc and retinol influence sputum conversion while vitamin D did not. PMID: 32778625 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Influence of New-Onset Atrial Fibrillation After Coronary Artery Bypass Grafting on Three-Year Survival.
CONCLUSION: new-onset atrial fibrillation after CABG independently decreases three-year survival. PMID: 32778626 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Effects of Extracardiac Factors in Signal-Averaged Electrocardiography-measured Late Potentials from Early Anterior Myocardial Infarction in Intensive Cardiac Care Unit.
CONCLUSION: patients with anterior MI who suffer from diabetes with hyperglycemia in admission, obesity, and dyslipidemia have a potentially higher LP prevalence, despite statistical insignificance. To increase the prognostic value of SA-ECG, serial examinations are needed during hospitalization. PMID: 32778627 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Association of Carcinoembryonic Antigen and Cytokeratin-19 Fragments 21-1 Levels with One-Year Survival of Advanced Non-Small Cell Lung Carcinoma at Cipto Mangunkusumo Hospital: A Retrospective Cohort Study.
CONCLUSION: from both tumour markers, only CYFRA 21-1 was proven to be significant to NSCLC survival. CYFRA 21-1 cut-off value as a prognostic factor was> 10.9 ng/mL. PMID: 32778628 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Difference in the Cyclin D1 Expression in Advanced Stage Nasopharyngeal Cancer based on Treatment Response: A Retrospective Cohort Study.
CONCLUSION: this study suggests that a higher expression of cyclin D1 is associated with a good treatment response in NPC patients. PMID: 32778629 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

A Family Cluster of Coronavirus Disease (COVID-19) Infection with Different Clinical Manifestations.
This report describes the epidemiological, clinical, radiological, laboratory findings, and different clinical manifestation of a family cluster of COVID-19 case in Indonesia. COVID-19 was transmitted from asymptomatic person in the incubation period. PMID: 32778630 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Role of Chest Radiograph, Procalcitonin and Moxifloxacin in Diagnosis and Management of Breast Cancer Patients with COVID-19.
Authors: Rinaldi I, Muthalib A, Astowo P, Irawan B, Susanto N, Magdalena L, Maha IHRT, Wicaksono S Abstract Global widespread of current coronavirus disease 2019 (COVID-19) pandemic has emerged huge predicament to healthcare systems globally. This disease caused by a new beta-type coronavirus, known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), may lead to systemic multiorgan dysfunction syndrome and subsequently cause death due to abundant angiotensin converting enzyme 2 as its functional receptors throughout body. Oncology patients even have a worse prognosis with greater infection susceptibili...
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Health Issues Among Healthcare Workers During COVID-19 Pandemic: a Psychosomatic Approach.
In conclusion, psychosomatic approach is important to keep the healthcare workers healthy. PMID: 32778632 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Acute Cerebellar Strokes with Anoxic Brain Injury After a Cardiopulmonary Arrest in SARS-CoV-2 Patient.
Authors: Janjua T, Moscote-Salazar LR Abstract Neurological complications from novel coronavirus is becoming more common. These patients usually have primary pulmonary problem of acute lung injury. Presentation in the form of encephalitis, meningitis, Guillain-Barre syndrome and seizures are noted. It is also noted that SARS-CoV-2 has predilection for brain stem leading to patient not feeling extensive pulmonary injury. Here we share another neurological presentation. PMID: 32778633 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Mass Panic Disaster Management in COVID-19 Pandemic.
Authors: Shatri H, Faisal E, Putranto R Abstract Coronavirus disease (COVID-19) pandemic occurred abruptly. It is an unexpected disaster. Uncertain treatment for this viral infection increases excessive anxiety, which does not occur only in one person but also in majority of people; therefore, it can create mass panic. Mass panic is a serious problem that must be immediately identified and managed. Mass panic management will reduce COVID-19 incidence. PMID: 32778634 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Palliative Management of Advanced Pancreatic Cancer: The Role of Gastroentero-hepatologist.
Authors: Adiwinata R, Livina A, Waleleng BJ, Tendean N, Gosal F, Rotty L, Winarta J, Waleleng A Abstract Pancreatic cancer commonly diagnosed at late stage due to subtle clinical manifestation and associated with low 5-year survival rate. Only 10-20% of patients were found in resectable or localized stage. Several complications may arise due to advanced pancreatic cancer such as obstructive jaundice, gastric outlet obstruction, pancreatic cancer cachexia, pruritus of cholestasis, and cancer pain. Palliative management should be optimized in order to improve patient's quality of life. A gastroentero-hepatologist sho...
Source: Acta medica Indonesiana - August 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Diagnosing COVID-19: Did We Miss Anything?
Authors: Tenda ED, Asaf MM Abstract In late 2019, a mass of patients showing symptoms of a pneumonia-like disease of unknown origin emerged in Wuhan, China. Little did the world know it was the prelude of what would be a devastating pandemic. Samples were collected from these patients and the use of unbiased sequencing, and subsequent isolation of the pathogen using human airway epithelial cells led to the discovery of a novel coronavirus, named 2019-nCoV by the World Health Organization (WHO) and Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses. The...
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Sarcopenia and Frailty Profile in the Elderly Community of Surabaya: A Descriptive Study.
CONCLUSION: the prevalence of sarcopenia and frailty in the elderly is significantly high, thus, it is expected that this study results are used as a basis for subsequent research, especially to determine the sarcopenia cut-off, in accordance with Indonesian sociodemography. PMID: 32291366 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

IDENTIA Registry: Incidence of Deep Vein Thrombosis in Medically Ill Subjects at High Risk in Indonesia: A Prospective Study.
CONCLUSION: this study indicated that the incidence of DVT is high in medically ill patients in Indonesia and will provide new insights and awareness about DVT in Indonesia. PMID: 32291367 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Comparative Effectiveness of Tuberculosis Treatment Daily versus Intermittent Regimen in Indonesian TB-DM Patients: Real World Patient Database Study.
CONCLUSION: there is no difference between sputum conversion profile and treatment success in advanced phase TB-DM treatment category 1 between the daily and intermittent regimen.ly for diabetic patients. PMID: 32291368 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Six-month Survival of Patients with Malignant Distal Biliary Stricture Following Endoscopic Biliary Stent Procedure and Its Associated Factors.
Authors: Kusumaningtyas L, Makmun D, Syam AF, Setiati S Abstract BACKGROUND: unresectable malignant distal biliary stricture patients require endoscopic biliary stent placement procedure. The survival rate and its associated factors in Indonesia are unknown. OBJECTIVES: To identify 6-month survival of patients with malignant distal biliary stricture following endoscopic biliary stent procedure and its associated factors. METHODS: a retrospective cohort study was conducted using medical records of patients with unresectable malignant distal biliary stricture, which involved caput of pancreas, ampulla of Vate...
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Three Years Survival of Elderly Cancer Patients in Indonesia: Do We Need a Different Approach?
CONCLUSION: the survival of elderly patients with cancer is affected by traditional prognostic factors. Advanced cancer stage was significant independent prognostic factor in female patients, while poor performance status was significant in male patients. PMID: 32291370 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Global Longitudinal Strain (GLS) in Elderly and Its Associated Factors.
This study aimed to determine the mean value of GLS and GLS-related factors. METHODS: this cross-sectional study was conducted among elderly patients aged> 60 years in the geriatric and cardiology clinic, Internal Medicine, CMH Hospital. Data were obtained from interviews, medical records, and transthoracic echocardiography examination. The variables of age, frailty, hypertension, coronary artery disease, dyslipidemia, and diabetes mellitus were analyzed as the determinants of a decrease in GLS. Univariate analysis was conducted for each variable. Bivariate analysis was conducted using the chi-square test with a significance level of p
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Pregnancy Profile and Infant Outcomes Among HIV Infected Women Who Delivered in Cipto Mangunkusumo Hospital.
CONCLUSION: HIV diagnosis in pregnant women is important, since ARV administration on early pregnancy significantly reduce vertical transmission. ARV prophylaxis protocols is important to prevent HIV infection on infant. PMID: 32291372 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Gastrointestinal Presentation in COVID-19 in Indonesia: A Case Report.
We report a patient in Indonesia with chest pain and gastrointestinal symptoms who was later confirmed to have SARS-CoV-2 infection after spending days of hospitalisation in the standard ward. PMID: 32291373 [PubMed - indexed for MEDLINE] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Importance of Chest CT Scan in COVID-19.
The objective of this case study is to investigate the importance and utility of chest computed tomography (CT) in the diagnosis of COVID-19, as increasing pieces of evidence suggest that chest CT could prove useful in the clinical pathway in diagnosing COVID-19. PMID: 32291374 [PubMed - indexed for MEDLINE] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Hyperkalemia Associated with Angiotensin Converting Enzyme Inhibitor or Angiotensin Receptor Blockers in Chronic Kidney Disease.
Authors: Oktaviono YH, Kusumawardhani N Abstract Inhibition of the renin-angiotensin-aldosterone system (RAAS) is a key strategy in treating hypertension in cardiovascular and renal diseases. However, RAAS inhibitors (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, aldosterone receptor antagonists, and direct renin inhibitors) increase the risk of hyperkalemia (serum potassium>5.5 mmol/L). This poses a therapeutic challenge because these patient groups comprise in whom the drugs are therapeutically indicated. Important considerations when initiating ACEI or ARB therapy include obtaining ...
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Clinical Progression of COVID-19 Patient with Extended Incubation Period, Delayed RT-PCR Time-to-positivity, and Potential Role of Chest CT-scan.
Authors: Burhan E, Prasenohadi P, Rogayah R, Isbaniyah F, Reisa T, Dharmawan I Abstract Coronavirus Disease 2019 (COVID-19), previously called 2019-nCoV, is a novel disease caused by SARS- CoV-2 which was first identified as outbreak of unknown respiratory illness in Wuhan, China. COVID- 19 was declared as global health emergency by WHO on March 11, 2020 and quickly elevated to global pandemic on 11 March 2020. COVID-19 symptom is highly various in each patient, with fever, fatigue, shortness of breath, and cough as the main presenting symptoms. Patient with COVID-19 may shows severe symptom with severe pneumonia a...
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

COVID-19 and Indonesia.
Authors: Setiati S, Azwar MK Abstract Coronavirus disease 2019 (COVID-19) pandemic is an ongoing problem in more than 200 countries in the world. Indonesia has been greatly affected by COVID-19 with case fatality rate (CFR) being 8.9% in the end of March 2020. We have some room for improvement related to the unreadingess of healthcare facility and the major steps taken by the government. It is suggested that the country should have stricter Stay-at-Home notice, suppress the spread by imposing lockdown on a large scale, improve healthcare service, and increase the availability of personal protective equipments (PPE)...
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Diagnosis and Management of Heatstroke.
Authors: Asmara IGY Abstract Heatstroke is a life-threatening  and the most severe form of heat-related illnesses, characterized by body temperature>40ºC and central nervous system dysfunction. Heatstroke is classified into Non-Exertional Heatstroke (NEHS) and Exertional Heatstroke (EHS). The pathophysiology of heatstroke involves a combination of direct heat effects on the host, the systemic inflammatory and coagulopathic response. The diagnosis of heatstroke based on Bouchama's definition or Japan Association of Acute Medicine (JAAM) criteria. The basic principle of heatstroke management is early res...
Source: Acta medica Indonesiana - April 17, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Targeting Inflammation and Immune System in Acute Myocardial Infarction.
Authors: Alwi I Abstract Over more than two decades, the concept of atherosclerosis has developed and lead to inflammatory hypothesis. Inflammation plays an important role on pathogenesis of atherothrombosis and coronary heart disease (CHD), including acute coronary syndrome (ACS). Although the management of ACS has been demonstrated to be beneficial for secondary prevention of coronary heart disease (such as using statin and aspirin) and also seemed to have positive effect on inflammation, the identification of effective management, specifically targeting inflammation, has been not been comprehensively understood....
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Plasma Concentrations of Adiponectin in Patients with Coronary Artery Disease and Coronary Slow Flow.
In this study we investigate the plasma concentration of adiponectin in patients with coronary artery disease (CAD), those with coronary slow flow (CSF) and in healthy subjects. METHODS: this study was conducted according to a cross-sectional design involving 30 CAD, 30 CSF, and 30 healthy subjects. These subjects were sourced from the Dr. Zainoel Abidin Center Hospital, Banda Aceh, Indonesia, between December 2017 and February 2018. The plasma concentration of adiponectin was measured using enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's specifications. RESULTS: there were statistically s...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Factors Associated with Pain in Palliative Patients and the Role of Spiritual Services in Pain Management.
CONCLUSION: pain in palliative patients is mainly experienced by cancer patients and the elderly. Psychological factors affect the condition of pain, so the management that includes biopsychosocial aspect will be able to reduce pain significantly. PMID: 32041912 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

A Double-blind, Randomized Controlled Trial of Ciplukan (Physalis angulata Linn) Extract on Skin Fibrosis, Inflammatory, Immunology, and Fibrosis Biomarkers in Scleroderma Patients.
Authors: Dewi S, Isbagio H, Purwaningsih EH, Kertia N, Setiabudy R, Setiati S Abstract BACKGROUND: scleroderma is an autoimmune disease characterized by organ fibrosis, resistant to standard treatment. It is suspected the addition of Physalis angulata Linn. (Ciplukan) extract as adjuvant therapy can improve the scleroderma skin fibrosis. The aim at this study is to evaluate the effect of ciplukan extract as adjuvant on scleroderma skin fibrosis in standard therapy, based on modified Rodnan skin scale (MRSS), inflammatory biomarkers, immunology and serum fibrosis. METHODS: double-blind, randomized clinical trial...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Effect of Oral N-Acetylcysteine Supplementation on the Immunity System in Patients with Acute Myocardial Infarction.
CONCLUSION: oral supplementation of 600 mg NAC every 8 h for 72 h can reduce HsCRP, MPO, and Gal-3 levels in AMI patients receiving fibrinolytic therapy. Results of our study will provide more options for supplementation therapy to improve management of IMA patients. PMID: 32041914 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Validity and Reliability of the Indonesian Version of Kidney Disease Quality of Life (KDQOL-36) Questionnaire in Hemodialysis Patients at Hasan Sadikin Hospital, Bandung, Indonesia.
Authors: Supriyadi R, Rakhima F, Gondodiputro RS, Darmawan G Abstract BACKGROUND: the prevalence of chronic kidney disease (CKD) and dialysis patients is increasing every year in Indonesia. The impact of CKD and dialysis on patient quality of life (QOL) has been recognized as an important outcome measure in the management of CKD. The Kidney Disease Quality of Life (KDQOL-36) has been validated and is widely used as a measure of QOL for CKD and dialysis patients in many countries, but not in Indonesia. The aim of this study is to determine the reliabity and validity of the Indonesian version of KDQOL-36 on hemodialy...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Factors Associated with Mortality of Intensive Care Unit Patients with Acute Kidney Injury at Cipto Mangunkusumo National Central General Hospital.
CONCLUSION: the prevalence of AKI patients and their mortality rate in the intensive care unit of Cipto Mangunkusumo General Hospital obtained 12.25% and 32.59%. Sepsis, oligoanuria, ventilators (APACHE II score at admission) 1/2, and ventilator duration are factors that are significantly associated with increased mortality of AKI patients in intensive care units. PMID: 32041916 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Intact Glycocalyx of Intestinal Mucosa in Intraabdominal Infection: an Investigation Using Blood Group Antigen.
CONCLUSION: this study shows there is no disrupted intestinal glycocalyx of sepsis patients caused by intraabdominal infection. PMID: 32041917 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

"Fleshy" Skin Cellulitis: A Triggering Factor for ANCA Associated Vasculitis.
"Fleshy" Skin Cellulitis: A Triggering Factor for ANCA Associated Vasculitis. Acta Med Indones. 2019 Oct;51(4):338-343 Authors: Yang SC, Mustafar R, Kamaruzaman L, Wei Yen K, Mohd R, Cader R Abstract A 59-year-old lady with underlying hypothyroidism presented with acute contact dermatitis progressed to cellulitis with superimposed bacterial infection and acute kidney injury. She responded to initial management with antibiotics, but a week later, she had cutaneous and systemic vasculitis. Her skin biopsy consistent with immune-mediated leuko-cytoclastic vasculitis and her blood test was positi...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

A Case Report on Cholestatic Jaundice Secondary to Adverse Effect of Phaleria macrocarpa (Mahkota Dewa).
The objective of this case report is to share the uncommon side effect of taking this traditional product which may have been under-reported due to the unknown effect. PMID: 32041919 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Role of STAT5 in Tyrosine Kinase Inhibitor (IMATINIB) Resistance in CML Patients.
Authors: Putri A, Rinaldi I, Louisa M, Koesnoe S Abstract Chronic myeloid leukemia (CML) is a clonal haemopoietic stem cell disorders with reciprocal translocation in chromosome 9 (ch9) and 22 (ch22) which cause the fusion of Break cluster region-Abelson murine leukemia (BCR-ABL) oncogene. This fusion will activate tyrosine kinase. Imatinib mesylate is the first tyrosine kinase inhibitor (TKI), which could change the prognosis of CML patients. However, there is a resistance to TKI's, and based on transcriptomic study, increase expression of gen signal transducer and activator of transcription (STAT) 5A and runt-rel...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Renal Tuberculosis: The Masquerader.
Authors: Supriyadi R, Darmawan G, Pranggono EH Abstract Tuberculosis (TB) remains a worldwide scourge and the most common cause of mortality from infectious disease. Around 95% of cases occur in developing country. Renal TB is a rare cases that complicates 3-4% of pulmonary TB patients and commonly overlooked in clinical practice due to its symptoms may mimic other diseases.A-39-year-old man was admitted to our institution due to flank pain. He had history of low grade fever and oligouria since 5 months prior. He had no complaint of cough, dyspnea, or night sweat. He was a non smoker and had no past medical history...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Is Higher BMI Associated with Worse Overall Mortality in Hepatocellular Carcinoma Patients? An Evidence Based Case Report.
CONCLUSION: there is no association between higher BMI with HCC-related mortality in Asian race patients. PMID: 32041922 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Practical Guidelines Management of Graves Ophthalmopathy.
Authors: Subekti I, Soewondo P, Soebardi S, Darmowidjojo B, Harbuwono DS, Purnamasari D, Tarigan TJE, Wisnu W, Tahapary DL, Kurniawan F, Sidik M, Nusanti S, Dewiputri S, Suharko H, Suardana GG, Suroyo I, Wulani V, Siswoyo AD, Gondhowiardjo S, Kodrat H Abstract Graves' ophthalmopathy is the most common extra-thyroid manifestation in patients with Graves' disease, based on inflammatory and autoimmune conditions in orbital tissue. This practical guideline was formed by a multidiciplinary team, and is intended to provide guidance for diagnosis and management of Graves' ophthalmopathy in daily clinical practice to impro...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Threat of Emerging and Re-emerging Infections in Indonesia.
In conclusion, the author of this paper mentioned that immunization gap needs to be handle systematically. Immunization data released on 2017 showed that complete immunization was given only to 20% of targeted group, while almost 75% were either unvaccinated or unknown. During the outbreak of diphteria in Indonesia, the WHO also reported several countries with similar problem such as Bangladesh, Haiti and Yamen. It was shown that a coordination between doctors in clinic/hospital with public health officer to conduct an epidemiological investigation, in conjunction with giving prophylaxis and assuring the logistics of anti-...
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Emergence of HIV-1 Transmitted Drug Resistance Mutations Among Antiretroviral Therapy-naive Individuals in Buleleng, Bali, Indonesia.
CONCLUSION: these results indicate the emergence of TDR among ART-naive individuals in Buleleng, Bali. This issue warrants serious consideration because TDR may hamper treatment success and reduce ART efficacy among newly diagnosed individuals. Continuous surveillance with a larger sample size is necessary to monitor TDR among ART-naive individuals. PMID: 31699942 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Diphtheria Epidemiology in Indonesia during 2010-2017.
CONCLUSION: in Indonesia, there was dramatic increase of diphtheria case in 2010-2017, where immunization in children should be reinforced by increasing coverage more than 95% and adult boosted vaccination approaches should be initiated to prevent the spread of these fatal diphtheria diseases in Indonesia. PMID: 31699943 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Low Body Mass Index as a Risk Factor for Antiretroviral Drug-Related Liver Injury Among HIV Patients.
Authors: Budiman B, Hartantri Y, Susandi E, Agustanti N Abstract BACKGROUND: antiretroviral drug-related liver injury (ARLI) is a drug-induced hepatotoxicity due to antiretroviral medication (ARV). It commonly disrupts compliance to treatment and causes treatment discontinuation in HIV-infected patients. Several studies have been conducted on predisposing factors for ARLI including studies on body mass index (BMI) and cluster of differentiation 4 (CD4). The association of BMI and CD4 with ARLI remains controversial as previous studies have demonstrated different outcomes. Our study was conducted to identify the ass...
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Factors Associated with Physical Frailty in Elderly Women with Low Socioeconomic Status in Urban Communities: A Cross-Sectional Study.
Authors: Rensa R, Setiati S, Laksmi PW, Rinaldi I Abstract BACKGROUND: there are differences in factors associated with frailty syndrome in elderly population. The aim of this research was to determine frailty status (fit, pre-frail and frail) and to identify factors associated with physical frailty in urban community-dwelling elderly women. METHODS: a cross-sectional study of community-dwelling women aged 60 years and older was conducted in West and Central Jakarta regions, Indonesia, from July until September 2017. The Cardiovascular Health Study (CHS) score was used to determine frailty status (fit/ pre-frai...
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Clinical Comparison of Renogen, a Biosimilar Epoetin-a, with the Originator, Eprex, in Chronic Kidney Disease Anemia in Indonesia: A Preliminary Study.
CONCLUSION: Hb level at>10 g/dL could be maintained for 8 weeks of treatment with both originator and biosimilar EPO (more consistent with originator EPO and more fluctuations with biosimilar EPO), with similar epoetin dose and no drug-related adverse event. PMID: 31699946 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Predictors of 30-day Mortality in ST-Elevation Myocardial Infarction (STEMI) Patients.
CONCLUSION: There are two new score variables that can be used as predictors of 30-day mortality risks for STEMI patients, i.e. the Killip class and GFR with satisfactory calibration and discrimination rate. PMID: 31699947 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Role of Serum Expression Levels of Microrna-21 on Bone Mineral Density in Hypostrogenic Postmenopausal Women with Osteoporosis: Study on Level of RANKL, OPG, TGF β-1, Sclerostin, RANKL/OPG Ratio, and Physical Activity.
CONCLUSION: serum miR-21 expression in PMOP was higher compared with PMNOP. Serum miR-21 expression proved to have a negative effect on spinal BMD values in hypoestrogenic postmenopausal women with osteoporosis of 8.5%. Obtained equation of BMD = 1.373-0.085*Ln.miR-21-0.176*Log10.RANKL can explain the value of spinal BMD by 52.5%. PMID: 31699948 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research