Targeting Inflammation and Immune System in Acute Myocardial Infarction.
Authors: Alwi I Abstract Over more than two decades, the concept of atherosclerosis has developed and lead to inflammatory hypothesis. Inflammation plays an important role on pathogenesis of atherothrombosis and coronary heart disease (CHD), including acute coronary syndrome (ACS). Although the management of ACS has been demonstrated to be beneficial for secondary prevention of coronary heart disease (such as using statin and aspirin) and also seemed to have positive effect on inflammation, the identification of effective management, specifically targeting inflammation, has been not been comprehensively understood....
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Plasma Concentrations of Adiponectin in Patients with Coronary Artery Disease and Coronary Slow Flow.
In this study we investigate the plasma concentration of adiponectin in patients with coronary artery disease (CAD), those with coronary slow flow (CSF) and in healthy subjects. METHODS: this study was conducted according to a cross-sectional design involving 30 CAD, 30 CSF, and 30 healthy subjects. These subjects were sourced from the Dr. Zainoel Abidin Center Hospital, Banda Aceh, Indonesia, between December 2017 and February 2018. The plasma concentration of adiponectin was measured using enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's specifications. RESULTS: there were statistically s...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Factors Associated with Pain in Palliative Patients and the Role of Spiritual Services in Pain Management.
CONCLUSION: pain in palliative patients is mainly experienced by cancer patients and the elderly. Psychological factors affect the condition of pain, so the management that includes biopsychosocial aspect will be able to reduce pain significantly. PMID: 32041912 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

A Double-blind, Randomized Controlled Trial of Ciplukan (Physalis angulata Linn) Extract on Skin Fibrosis, Inflammatory, Immunology, and Fibrosis Biomarkers in Scleroderma Patients.
Authors: Dewi S, Isbagio H, Purwaningsih EH, Kertia N, Setiabudy R, Setiati S Abstract BACKGROUND: scleroderma is an autoimmune disease characterized by organ fibrosis, resistant to standard treatment. It is suspected the addition of Physalis angulata Linn. (Ciplukan) extract as adjuvant therapy can improve the scleroderma skin fibrosis. The aim at this study is to evaluate the effect of ciplukan extract as adjuvant on scleroderma skin fibrosis in standard therapy, based on modified Rodnan skin scale (MRSS), inflammatory biomarkers, immunology and serum fibrosis. METHODS: double-blind, randomized clinical trial...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Effect of Oral N-Acetylcysteine Supplementation on the Immunity System in Patients with Acute Myocardial Infarction.
CONCLUSION: oral supplementation of 600 mg NAC every 8 h for 72 h can reduce HsCRP, MPO, and Gal-3 levels in AMI patients receiving fibrinolytic therapy. Results of our study will provide more options for supplementation therapy to improve management of IMA patients. PMID: 32041914 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Validity and Reliability of the Indonesian Version of Kidney Disease Quality of Life (KDQOL-36) Questionnaire in Hemodialysis Patients at Hasan Sadikin Hospital, Bandung, Indonesia.
Authors: Supriyadi R, Rakhima F, Gondodiputro RS, Darmawan G Abstract BACKGROUND: the prevalence of chronic kidney disease (CKD) and dialysis patients is increasing every year in Indonesia. The impact of CKD and dialysis on patient quality of life (QOL) has been recognized as an important outcome measure in the management of CKD. The Kidney Disease Quality of Life (KDQOL-36) has been validated and is widely used as a measure of QOL for CKD and dialysis patients in many countries, but not in Indonesia. The aim of this study is to determine the reliabity and validity of the Indonesian version of KDQOL-36 on hemodialy...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Factors Associated with Mortality of Intensive Care Unit Patients with Acute Kidney Injury at Cipto Mangunkusumo National Central General Hospital.
CONCLUSION: the prevalence of AKI patients and their mortality rate in the intensive care unit of Cipto Mangunkusumo General Hospital obtained 12.25% and 32.59%. Sepsis, oligoanuria, ventilators (APACHE II score at admission) 1/2, and ventilator duration are factors that are significantly associated with increased mortality of AKI patients in intensive care units. PMID: 32041916 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Intact Glycocalyx of Intestinal Mucosa in Intraabdominal Infection: an Investigation Using Blood Group Antigen.
CONCLUSION: this study shows there is no disrupted intestinal glycocalyx of sepsis patients caused by intraabdominal infection. PMID: 32041917 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

"Fleshy" Skin Cellulitis: A Triggering Factor for ANCA Associated Vasculitis.
"Fleshy" Skin Cellulitis: A Triggering Factor for ANCA Associated Vasculitis. Acta Med Indones. 2019 Oct;51(4):338-343 Authors: Yang SC, Mustafar R, Kamaruzaman L, Wei Yen K, Mohd R, Cader R Abstract A 59-year-old lady with underlying hypothyroidism presented with acute contact dermatitis progressed to cellulitis with superimposed bacterial infection and acute kidney injury. She responded to initial management with antibiotics, but a week later, she had cutaneous and systemic vasculitis. Her skin biopsy consistent with immune-mediated leuko-cytoclastic vasculitis and her blood test was positi...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

A Case Report on Cholestatic Jaundice Secondary to Adverse Effect of Phaleria macrocarpa (Mahkota Dewa).
The objective of this case report is to share the uncommon side effect of taking this traditional product which may have been under-reported due to the unknown effect. PMID: 32041919 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Role of STAT5 in Tyrosine Kinase Inhibitor (IMATINIB) Resistance in CML Patients.
Authors: Putri A, Rinaldi I, Louisa M, Koesnoe S Abstract Chronic myeloid leukemia (CML) is a clonal haemopoietic stem cell disorders with reciprocal translocation in chromosome 9 (ch9) and 22 (ch22) which cause the fusion of Break cluster region-Abelson murine leukemia (BCR-ABL) oncogene. This fusion will activate tyrosine kinase. Imatinib mesylate is the first tyrosine kinase inhibitor (TKI), which could change the prognosis of CML patients. However, there is a resistance to TKI's, and based on transcriptomic study, increase expression of gen signal transducer and activator of transcription (STAT) 5A and runt-rel...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Renal Tuberculosis: The Masquerader.
Authors: Supriyadi R, Darmawan G, Pranggono EH Abstract Tuberculosis (TB) remains a worldwide scourge and the most common cause of mortality from infectious disease. Around 95% of cases occur in developing country. Renal TB is a rare cases that complicates 3-4% of pulmonary TB patients and commonly overlooked in clinical practice due to its symptoms may mimic other diseases.A-39-year-old man was admitted to our institution due to flank pain. He had history of low grade fever and oligouria since 5 months prior. He had no complaint of cough, dyspnea, or night sweat. He was a non smoker and had no past medical history...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Is Higher BMI Associated with Worse Overall Mortality in Hepatocellular Carcinoma Patients? An Evidence Based Case Report.
CONCLUSION: there is no association between higher BMI with HCC-related mortality in Asian race patients. PMID: 32041922 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Practical Guidelines Management of Graves Ophthalmopathy.
Authors: Subekti I, Soewondo P, Soebardi S, Darmowidjojo B, Harbuwono DS, Purnamasari D, Tarigan TJE, Wisnu W, Tahapary DL, Kurniawan F, Sidik M, Nusanti S, Dewiputri S, Suharko H, Suardana GG, Suroyo I, Wulani V, Siswoyo AD, Gondhowiardjo S, Kodrat H Abstract Graves' ophthalmopathy is the most common extra-thyroid manifestation in patients with Graves' disease, based on inflammatory and autoimmune conditions in orbital tissue. This practical guideline was formed by a multidiciplinary team, and is intended to provide guidance for diagnosis and management of Graves' ophthalmopathy in daily clinical practice to impro...
Source: Acta medica Indonesiana - February 13, 2020 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Threat of Emerging and Re-emerging Infections in Indonesia.
In conclusion, the author of this paper mentioned that immunization gap needs to be handle systematically. Immunization data released on 2017 showed that complete immunization was given only to 20% of targeted group, while almost 75% were either unvaccinated or unknown. During the outbreak of diphteria in Indonesia, the WHO also reported several countries with similar problem such as Bangladesh, Haiti and Yamen. It was shown that a coordination between doctors in clinic/hospital with public health officer to conduct an epidemiological investigation, in conjunction with giving prophylaxis and assuring the logistics of anti-...
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Emergence of HIV-1 Transmitted Drug Resistance Mutations Among Antiretroviral Therapy-naive Individuals in Buleleng, Bali, Indonesia.
CONCLUSION: these results indicate the emergence of TDR among ART-naive individuals in Buleleng, Bali. This issue warrants serious consideration because TDR may hamper treatment success and reduce ART efficacy among newly diagnosed individuals. Continuous surveillance with a larger sample size is necessary to monitor TDR among ART-naive individuals. PMID: 31699942 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Diphtheria Epidemiology in Indonesia during 2010-2017.
CONCLUSION: in Indonesia, there was dramatic increase of diphtheria case in 2010-2017, where immunization in children should be reinforced by increasing coverage more than 95% and adult boosted vaccination approaches should be initiated to prevent the spread of these fatal diphtheria diseases in Indonesia. PMID: 31699943 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Low Body Mass Index as a Risk Factor for Antiretroviral Drug-Related Liver Injury Among HIV Patients.
Authors: Budiman B, Hartantri Y, Susandi E, Agustanti N Abstract BACKGROUND: antiretroviral drug-related liver injury (ARLI) is a drug-induced hepatotoxicity due to antiretroviral medication (ARV). It commonly disrupts compliance to treatment and causes treatment discontinuation in HIV-infected patients. Several studies have been conducted on predisposing factors for ARLI including studies on body mass index (BMI) and cluster of differentiation 4 (CD4). The association of BMI and CD4 with ARLI remains controversial as previous studies have demonstrated different outcomes. Our study was conducted to identify the ass...
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Factors Associated with Physical Frailty in Elderly Women with Low Socioeconomic Status in Urban Communities: A Cross-Sectional Study.
Authors: Rensa R, Setiati S, Laksmi PW, Rinaldi I Abstract BACKGROUND: there are differences in factors associated with frailty syndrome in elderly population. The aim of this research was to determine frailty status (fit, pre-frail and frail) and to identify factors associated with physical frailty in urban community-dwelling elderly women. METHODS: a cross-sectional study of community-dwelling women aged 60 years and older was conducted in West and Central Jakarta regions, Indonesia, from July until September 2017. The Cardiovascular Health Study (CHS) score was used to determine frailty status (fit/ pre-frai...
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Clinical Comparison of Renogen, a Biosimilar Epoetin-a, with the Originator, Eprex, in Chronic Kidney Disease Anemia in Indonesia: A Preliminary Study.
CONCLUSION: Hb level at>10 g/dL could be maintained for 8 weeks of treatment with both originator and biosimilar EPO (more consistent with originator EPO and more fluctuations with biosimilar EPO), with similar epoetin dose and no drug-related adverse event. PMID: 31699946 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Predictors of 30-day Mortality in ST-Elevation Myocardial Infarction (STEMI) Patients.
CONCLUSION: There are two new score variables that can be used as predictors of 30-day mortality risks for STEMI patients, i.e. the Killip class and GFR with satisfactory calibration and discrimination rate. PMID: 31699947 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Role of Serum Expression Levels of Microrna-21 on Bone Mineral Density in Hypostrogenic Postmenopausal Women with Osteoporosis: Study on Level of RANKL, OPG, TGF β-1, Sclerostin, RANKL/OPG Ratio, and Physical Activity.
CONCLUSION: serum miR-21 expression in PMOP was higher compared with PMNOP. Serum miR-21 expression proved to have a negative effect on spinal BMD values in hypoestrogenic postmenopausal women with osteoporosis of 8.5%. Obtained equation of BMD = 1.373-0.085*Ln.miR-21-0.176*Log10.RANKL can explain the value of spinal BMD by 52.5%. PMID: 31699948 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

HIV Drug Resistance after Failure of 6 Month First-line Therapy in a Hospital: A Case Series.
Authors: Kusumaningrum A, Ibrahim F, Yunihastuti E, Bela B Abstract This is the first report of HIV drug resistance in RSUPN Dr. Cipto Mangunkusumo. We tested We reviewed eleven new cases of HIV patients who had virologic failure after 6 months first-line antiretroviral therapy. With the sequencing method, analysis of gene mutations encoded HIV drug resistance. Genotypic resistance results and HIV-1 subtype were interpreted by Stanford DR database. Of ten plasma samples that were successfully amplified and sequenced, all samples were resistant to at least one antiretroviral drug. Genotypic resistance towards the an...
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Acquired Hemophilia A Associated with NSAID: A Case Report.
Authors: Setiawan DL, Hernaningsih Y Abstract Acquired hemophilia A (AHA) is a blood clotting disorder caused by the presence of autoantibodies (inhibitors) against factor VIII. The typical symptom of this disorder is bleeding under the skin and soft tissue (rarely in the joints), with no family or personal previous history of bleeding. This case reports is tended to build up awareness for better diagnosis and therapy. Woman, 39 years old, bruises on both forearms are intermittent for 2 months with a history of long term drug consumption for headache treatment. Hemostatic test showed the elongation of activated par...
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Diabetic Gastroenteropathy: A Complication of Diabetes Mellitus.
Authors: Kurniawan AH, Suwandi BH, Kholili U Abstract Diabetic gastroenteropathy is a common complication in prolonged diabetic patients, particularly patients with poor glycemic control or other complications, including all form of diabetic complication on the gastrointestinal tract, which prompts various symptoms of heartburn, abdominal pain, nausea, vomiting, even constipation, diarrhea, and fecal incontinence. The underlying pathophysiology of this complication manifestations are different on each organ or symptom, but may include autonomic nervous system neuropathy, loss of Interstitial Cell of Cajal as gastri...
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Late Diagnosis of Congenital Hypothyroidism in Young Adult.
Authors: Pramono LA, Yuwono A Abstract Congenital hypothyroidism is the most treatable cause of mental retardation. It is also the most prevalent congenital endocrine disorder in childhood. A dramatic improvement can be made by early detection, diagnosis, and adequate treatment of levothyroxine in patients with congenital hypothyroidism. Severe cognitive impairment is associated with persistent disease in patients who have delayed or no treatment at all. In a modern era with complete healthcare facilities in a big city like Jakarta, the prevalence late-diagnosed congenital hypothyroidism is supposed to be very low....
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Tadalafil Once a Day for Men with Erectile Dysfunction: Is It Superior than On-Demand Administration?
CONCLUSION: administration of tadalafil OAD leads to a better improvement of EF compared to PRN administration. PMID: 31699953 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Aspirin vs. P2Y12 Inhibitor Rivalry: Which One Can be Continued During Gastrointestinal Bleeding.
Authors: Bestari MB, Joewono IR Abstract Dual antiplatelet therapy (DAPT) is the mainstay of secondary prevention treatment for acute coronary syndrome (ACS) and ischemic stroke, especially after coronary intervention. DAPT consists of aspirin and P2Y12 receptor inhibitor (e.g. clopidogrel), and the use of DAPT has been increased over time. The most serious and common adverse effect is gastrointestinal bleeding. Guidelines in managing such condition are available among Gastroenterologist Societies and Cardiologist Societies. Most guidelines are consistent with each other to continue the use of aspirin while withhol...
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Diagnostic Tools for Sarcopenia: Can We Get Less Expensive and Accurate Methods?
Authors: Setiati S Abstract Sarcopenia, as defined by the European Working Group on Sarcopenia (EWGSOP) in Older People is "a progressive and generalized skeletal muscle disorder that is associated with increased likelihood of adverse outcomes including falls, fractures, physical disability, and mortality". The first EWGSOP and Asian Working Group for Sarcopenia used muscle mass to define sarcopenia, which is diagnosed by using Dual-energy X-Ray absorptiometry (DXA). However, the cut-off from several countries in Asian showed different cut-off value for different age groups and BMI. In addition, not all h...
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Need for a New Cut-off Value to Increase Diagnostic Performance of Bioelectrical Impedance Analysis Compared with Dual-Energy X-ray Absorptiometry to Measure Muscle Mass in Indonesian Elderly.
Authors: Laksmi PW, Sukma FA, Setyohadi B, Nugroho P, Ariane A, Tirtarahardja G Abstract BACKGROUND: the use of bioelectrical impedance analysis (BIA) is affected by the population setting, the type of BIA, and the cut-off point being used. The aim of this study was to determine the diagnostic performance of BIA to measure muscle mass in Indonesian elderly outpatients aged 60 years or more. METHODS: a cross-sectional study was conducted at the Geriatric Clinic of Cipto Mangunkusumo Hospital from April to June 2018. The muscle mass was measured using BIA Tanita MC-780MA (Tokyo, Japan) with dual-energy x-ray abso...
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Risk Factors for Poor Pregnancy Outcome in Systemic Lupus Erythematosus Patients.
CONCLUSION: the pregnancy in SLE patient should be planned to have better outcome. Lupus nephritis and neuropsychiatric (NP) SLE were risk factors for poor pregnancy outcome in SLE patient. PMID: 31383824 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Effect of Vitamin E Supplementation on Lipid Profiles and Adiponectin Levels in Obese Adolescents: A Randomized Controlled Trial.
CONCLUSION: in obese adolescents, vitamin E supplementation of 400 IU/day for 2 months does not significantly affect lipid profiles and adiponectin levels. PMID: 31383825 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Diagnostic Performance of Calf Circumference, Thigh Circumference, and SARC-F Questionnaire to Identify Sarcopenia in Elderly Compared to Asian Working Group for Sarcopenia's Diagnostic Standard.
CONCLUSION: combination of calf and thigh circumference with SARC-F questionnaire showed good diagnostic accuracy in predicting sarcopenia in elderly outpatients. PMID: 31383826 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Role of Hepatitis C Virus NS5A Region Mutation and SNP IL-28B of Host to Support Successful Pegylated Interferon and Ribavirin Treatment in Patients with HCV-HIV Coinfection: A Prospective Cohort Study.
Authors: Kurniawan J, Gani RA, Djauzi S, Ibrahim F, Harimurti K, Nafrialdi N, Imannuel S Abstract BACKGROUND: HIV infection in HCV-infected patients accelerates disease progression and reduces the success rate of Peg-IFN/RBV treatment. HCV mutation in NS5A-ISDR/PKR-BD region improved the outcome in HCV monoinfection treated with Peg-IFN/RBV. SNP-IL28B polymorphism is predicted to have an effect on HCV quasispecies evolution. However, the role of NS5A mutation and SNP IL-28B in HIV-HCV coinfection is still unclear. The aim of the study is to determine the role of HCV NS5A-ISDR/PKR-BD mutation and SNP IL-28 polymorph...
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Expressions of CD44, CD90 and Alpha Fetoprotein Biomarkers in Indonesian Patients with Advanced Liver Disease: an Observational Study.
Authors: Mustika S, Wijaya H, Pratomo B Abstract BACKGROUND: increased serum alpha fetoprotein (AFP) levels are often found in patients with advanced hepatocellular carcinoma (HCC). Cluster Differentiation 44 (CD44) and CD90 are stem cell biomarkers that have been assumed as the early HCC markers and associated with onset and progressivity of HCC. The study related to HCC stem cell has not been available in Indonesia. The present study aimed to evaluate the expression of cancer stem cell markers (CD44, CD90) and AFP levels in patients with advanced liver disease. METHODS: an observational study was conducted in...
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Survival Rate of Cervical Cancer in National Referral Hospital in 2012 - 2014.
Authors: Nuranna L, Fahrudin A Abstract BACKGROUND: cervical cancer is the third leading cause of female deaths worldwide, and it is the leading cause of female deaths in developing countries. A routine survival evaluation is required to imply the result of the treatment. The aim of this study was to determine the cervical cancer patient survival rate at the Cipto Mangunkusumo hospital as national referral hospital in Indonesia. METHODS: our retrospective cohort study utilized the medical records of cervical cancer patients from 2012 to 2014 using total population sampling method. The data analysis was conducte...
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Characteristics of Palliative Patients, Insights of Patients and Families, and the Impact of Estimated Survival Time on Therapy Decisions.
CONCLUSION: female, elderly, and cancer patients most often get palliative therapy. The consent for DNR orders to palliative patient is notably frequent. Currently, the family's insight is much better than the patient's, which means that health care providers need to improve patient education and information. In addition, patients and families generally still opt for optimal therapy despite low estimated survival time. PMID: 31383830 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Adult-onset Still's Disease as a Differential Diagnosis in Prolonged Fever: Diagnosis and Treatment Experience.
We present a case of 36-year old man who experienced high prolonged fever which firstly thought as infection. He also had unilateral wrist and knee joint pain and maculopapular rash. Laboratory examination showed high leukocytes count with elevated polymorphonuclear neutrophil count, high platelet count, high ferritin level, and negative results of many infection markers (typhoid antibody, procalcitonin, malaria test, blood culture, urine culture, IgM pneumonia, ASTO, syphilis test, antiHIV, HBsAg, antiHCV, etc). Chest X-ray, joint X-ray, ultrasonography, and echocardiography showed normal result. The patient was then diag...
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

An 18-Year-Old Man with Idiopathic Non-cirrhotic Portal Hypertension.
We reported case of male patient with NCPH that had hematemesis because of rupture of esophageal varices. PMID: 31383832 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Subclinical Atherosclerosis in Young Adult Population with First Degree Relatives of Type 2 Diabetes Mellitus.
Authors: Abdaly MS, Azizi MS, Wijaya IP, Nugroho P, Purnamasari D Abstract Cardiovascular disease (CVD) remain a leading cause of death globally. The concept of acute myocardial infarction in young adults was uncommon. Atherosclerosis is the leading cause of CVD, including myocardial infarction, stroke, heart failure and peripheral artery disease. This condition is initiated early in childhood and progressive in nature. CVD risk factors includes hypertension, dyslipidemia and obesity play a role in the development of atherosclerosis and  components in insulin resistance syndrome.One of many risk factors for in...
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Human Tapeworm from Simalungun, Indonesia.
Authors: Zein U, Siregar S, Habib H, Janis I, Pane AH, Sardjono TW Abstract A 46-years-old man from Indonesia, resides in Nagori Dolok Village, Silau Kahaean Subdistrict, Simalungun District, Sumatra Utara Province, had of spontaneous discharge of tapeworm segments (proglottids) from anus almost every day for ten years. There were 1-5 segments which can move actively discharge per day. Although he feels embarrassed about the condition, no significant symptoms were found, and physical examination was within normal limits. Clinical diagnosis of Taeniasis was made on October 20, 2017, and subsequently received oral Pr...
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Risk of Developing Non-Alcoholic Fatty Liver Disease in Adult Patients with Subclinical Hypothyroidism Compared to Euthyroid: An Evidence-based Case Report.
CONCLUSION: patients with subclinical hypothyroidism, compared to euthyroid patients, are at higher risk of developing NAFLD. PMID: 31383835 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Diagnostic Approach for Thyroid Nodules.
Authors: Harbuwono DS, Soewondo P, Yunir E, Soebardi S, Darmowidjojo B, Purnamasari D, Tarigan TJE, Wisnu W, Tahapary DL, Kurniawan F, Yulian ED, Lisnawati L, Stephanie A, Makes B, Zulkarnaien B, Suroyo I, Siswoyo AD, Gondhowiardjo S, Kodrat H, Hermani B, Adham M, Subekti I Abstract Thyroid nodule is a health problem which commonly found in daily practice, therefore clinical guidance is needed. This guideline was compiled by a multidisciplinary team and expected to be a guideline in diagnosing thyroid nodules on daily clinical practice. PMID: 31383836 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 7, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Fragmented QRS (fQRS) in Acute Coronary Syndrome: Is It a More Potential Marker Than Predicted?
Authors: Ranitya R Abstract Fragmented QRS (fQRS) complexes are electrocardiographic (ECG) findings which reflect impaired ventricular depolarization due to heterogeneous electrical activation of ischemic and or injured myocardium. Therefore, it had been associated with many cardiovascular diseases both ischemic and non-ischemic origin. To date, fQRS is considered a novel and convenient marker of myocardial scar or fibrosis. Thus, it has gained more interest to investigate the potential use of fQRS in cardiac disease, especially in acute coronary syndrome (ACS). PMID: 31073099 [PubMed - in process] (Source: Act...
Source: Acta medica Indonesiana - May 12, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The Role of Fragmented QRS (fQRS) As A Predictor of Major Adverse Cardiac Event within 30 days in Acute Coronary Syndrome Patients: A Retrospective Cohort Study.
This study aimed to identify the role of fQRS as one of the risk factors for MACE (cardiac death and reinfarction) in acute coronary syndrome patients within 30 days observation. METHODS: a cohort retrospective study was conducted using secondary data of acute coronary syndrome patients at Intensive Cardiac Care Unit Cipto Mangunkusumo Hospital from July 2015 to October 2017. Multivariate analysis were done by using logistic regression with GRACE score (moderate and high risk), low eGFR (
Source: Acta medica Indonesiana - May 12, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Optimization of Intermittent Vancomycin Dosage Regimens for Thai Critically Ill Population Infected by MRSA in the Era of the "MIC Creep" Phenomenon.
CONCLUSION: the result from this study recommended intermittent dosage regimen 1.5g every 12h and 2g every 12h should be implemented as definite antibiotic treatment when considered infection caused by MRSA with MIC 1.5 and 2.0 mg/L, respectively. PMID: 31073101 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - May 12, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Safety and Efficacy of NC120 for Improving Lipid Profile: A Double Blind Randomized Controlled Trial.
CONCLUSION: NC120 is effective in reducing total cholesterol and LDL-cholesterol, but not triglyceride. This drug shows a good safety profile, and thus can be considered for patients who can not tolerate statin drugs. PMID: 31073102 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - May 12, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Validity and Reliability Studies of the Indonesian Version of the Minnesota Living with Heart Failure Questionnaire (MLHFQ): Quality of Life Questionnaire for Patients with Chronic Heart Failure.
This study aimed to obtain a valid and reliable Indonesian version of the Minnesota Living with Heart Failure Questionnaire (MLHFQ) so that it can be used in Indonesia. METHODS: the present study was a cross sectional study with 85 subjects (mean age 58 (SD 11) years; 55% subjects were male) who had chronic heart failure and was treated at the outpatient clinic of cardiology in Dr. Cipto Mangunkusumo Hospital, Jakarta. Validity of the MLHFQ was assessed by evaluating the construct validity using multitrait-multimethod analysis and external validity was evaluated by compairing  the MLHFQ with the SF-36 questionnair...
Source: Acta medica Indonesiana - May 12, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Detecting the Helicobacter pylori 16S rRNA Gene in Dyspepsia Patients Using Real-Time PCR.
Conclusion: the real-time PCR examination is more sensitive than histopathology. This technique can improve diagnosis by 11% compared to histopathological examination. PMID: 31073104 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - May 12, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Profile of Kawasaki Disease in Adolescents: Is It Different?
CONCLUSION: Kawasaki disease in adolescents has some different clinical profile from that of younger age. Majority of adolescent patients have incomplete presentation. Some clinical features such as conjunctivitis, mucosal changes, rash, and hand/foot changes are more often seen in children ≤ 10 years compared to in adolescents, while cervical lymphadenopathy and coronary dilatation are more frequently seen in adolescents. The ratio of male to female is much higher in adolescents. PMID: 31073105 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - May 12, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research