Gonadal tumour risk in 292 phenotypic female patients with disorders of sex development containing Y chromosome or Y ‐derived sequence

ConclusionDisorders of sex development patients with Y chromosome materials have a significantly increased risk of GCTs. Gonadoblastoma and dysgerminoma/seminoma are the most prevalent GCTs and 46, XY PGD carries the highest tumour presence and malignancy risk. AIS could postpone bilateral gonadectomy until or after adolescence, while others with streak gonads should undergo surgery as soon as diagnosis. Specific serum tumour markers could be used in predicting GCTs and monitoring. Optimal care and close follow‐up are required.
Source: Clinical Endocrinology - Category: Endocrinology Authors: Tags: Original Article Source Type: research