<Editors' Choice> How to improve outcomes of elderly patients with acute myeloid leukemia: era of excitement.
Authors: Tomoki N Abstract Among elderly patients with acute myeloid leukemia (AML), especially those who are unfit for intensive chemotherapy, a policy of reduced-intensity chemotherapy or conservative observation has been chosen, resulting in unmet medical needs. Clinical trials using anticancer drugs including antimetabolites or drugs targeted to cell cycle-related molecules failed to show superiority over conventional treatments. Recently, drugs targeted to Bcl-2, SMO, FLT3, and IDH1/2 have been shown to prolong overall survival alone or in combination with reduced-intensity chemotherapy. These treatments are l...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Current trends in thoracic surgery.
Authors: Chen-Yoshikawa TF, Fukui T, Nakamura S, Ito T, Kadomatsu Y, Tsubouchi H, Ueno H, Sugiyama T, Goto M, Mori S, Ozeki N, Hakiri S, Kawaguchi K Abstract Thoracic surgery has evolved drastically in recent years. Although thoracic surgeons mainly deal with tumorous lesion in the lungs, mediastinum, and pleura, they also perform lung transplantation surgery in patients with end-stage lung disease. Herein, we introduce various major current topics in thoracic surgery. Minimally invasive surgical procedures include robot-assisted thoracic surgery and uniportal video-assisted thoracic surgery. Novel techniques for s...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Nonexposed wall-inversion surgery as a novel local resection method for neoplasms in the gastrointestinal tract.
Authors: Fujishiro M, Furukawa K, Yamamura T, Nakamura M, Honda T, Maeda O, Ishigami M, Kawashima H Abstract Nonexposed wall-inversion surgery was invented for the treatment of node-negative gastrointestinal tumors that are difficult to be resected using the endoluminal approach alone. The advantages of this surgery include 1. full-thickness resection procedure of gastrointestinal wall with minimum necessary tumor-negative margins and 2. less risk of bacterial contamination and tumor seeding into the abdominal cavity. We conducted a PubMed search to select relevant articles published until the end of October 2019 f...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study.
This study aimed to study the incidence of HM and post-molar GTN and identify factors associated with post-molar GTN at a tertiary hospital in Vietnam. Five hundred and eighty-four patients who were treated for HM at Tu Du Hospital between January and December 2010 were included in this study. The mean age and gestational age at the first evacuation were 28.8 years old and 11.0 weeks, respectively. After the initial evacuation and pathological examination, 87 patients who were older than 40 or did not wish to have children underwent a hysterectomy, while the others underwent second curettage. All 472 patients who had human...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

The ethics of blood transfusion refusal in clinical practice among legal and medical professions in Japan.
Authors: Iijima Y Abstract We investigated the differences in Japanese and United States medical and legal professional opinions on ethical support for clinical ethical issues using the refusal of blood transfusions on the grounds of religious principles as an example of a clinical ethical issue. In ethical support systems for medical institutions in Japan, 95.0% of "clinical training designation hospitals" have hospital ethics committees, and 63.1% have medical safety divisions; clinical ethical support is provided in accordance with their scale and function. In terms of clinical ethical support limits t...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Unexpected radioactive iodine accumulation on whole-body scan after I-131 ablation therapy for differentiated thyroid cancer.
In conclusion, Patients with Tg> 1.5 ng/ml were more likely to show metastatic accumulation. In addition, the presence of lymph node metastasis at the initial thyroid surgery was also associated with this unexpected metastatic accumulation. PMID: 32581401 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Influence of human adipose stem cells on prostate cancer cell growth.
Authors: Tokunori Yamamoto, Gotoh M, Koide N, Funahashi Y, Shimizu S, Takei Y Abstract In a novel regenerative cell-based treatment developed by us for the patients with stress urinary incontinence, autologous adipose-derived stem cells (ASCs) are injected into the periurethral region and the external urethral sphincter. Since the candidates for this treatment included prostate cancer patients after radical prostatectomy, we investigated the effects of ASCs on prostate cancer cell proliferation in vitro and in vivo to confirm the feasibility of our therapeutic approach. The LNCaP (human prostate cancer cell line) c...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Is cell block technique useful to predict histological type in patients with ovarian mass and/or body cavity fluids?
Authors: Maseki Z, Kajiyama H, Nishikawa E, Satake T, Misawa T, Kikkawa F Abstract The cell block (CB) technique is a generalized method utilized for the diagnostic evaluation of body cavity fluids. Ascites cytology is one of the most important diagnostic processes for epithelial ovarian cancer. However, in clinical practice, the usefulness of the CB method to diagnose this tumor remains unelucidated. Between 2008 and 2017, 15 peritoneal or pleural fluid samples obtained from patients with ovarian or peritoneal carcinoma or other gastrointestinal malignancies were preoperatively subjected to a diagnostic evaluation...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Association between dietary inflammatory index and serum C-reactive protein concentrations in the Japan Collaborative Cohort Study.
We examined the association between DII scores and serum high-sensitivity C-reactive protein (hs-CRP) concentrations using the baseline data from the Japan Collaborative Cohort Study (JACC Study). Data were from 1176 control subjects (650 men and 526 women) in a nested case-control study of several cancers and CVD in the JACC Study who were free of cancer and CVD at baseline. DII scores were calculated from 26 food parameters that were derived from a validated food frequency questionnaire administered at the baseline. Energy-adjusted DII scores were calculated using the residual method. Serum hs-CRP concentrations were mea...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Nursing activities at clinics in rural areas in Japan: gaps between recognition of importance and implementation.
This study determined the level of implementation and the importance placed on various nursing activities at clinics in rural areas of Japan in order to explore the achievement and perceived importance of implementing certain nursing roles and activities at such clinics. To identify these items, a questionnaire was administered to 40 nurses working in rural clinics. The results showed that activities related to "Basic Nursing Practice" and "Community Understanding" were recognized as important and were performed by almost all nurses. Some activities related to "Administration and Operation" an...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes.
Authors: Inoue C, Sobue S, Mizutani N, Kawamoto Y, Nishizawa Y, Ichihara M, Takeuchi T, Hayakawa F, Suzuki M, Ito T, Nozawa Y, Murate T Abstract Resveratrol (RSV) has recently attracted keen interest because of its pleiotropic effects. It exerts a wide range of health-promoting effects. In addition to health-promoting effects, RSV possesses anti-carcinogenic activity. However, a non-physiological concentration is needed to achieve an anti-cancer effect, and its in vivo bioavailability is low. Therefore, the clinical application of phytochemicals requires alternative candidates that induce the desired effects at a l...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Contributions of residual hypoxemia to exercise hyperventilation in Fontan patients.
Authors: Okamura Y, Kito M, Yasuda K, Baba R Abstract It is unsettled whether increased exercise ventilation in Fontan subjects is due to increased pulmonary dead space or augmented ventilatory drive. Twenty-six Fontan patients underwent symptom-limited treadmill cardiopulmonary exercise testing. Two groups of age- and sex- matched subjects served as controls: the biventricularly repaired (Bi, n = 18), and the "true" control (C, n = 29) groups. Peak oxygen uptake (V̇O2peak) was not different among groups (41.0 +/- 8.4 ml/min/kg, 43.5 +/- 6.6 ml/min/kg, and 45.9 +/- 11.6 ml/min/kg for Fontan, Bi, and C gr...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Correlation between blood flow, tissue volume and microvessel density in the flap.
In this study, we assessed flap conductance (ml/min/mm Hg) as to evaluate the conductivity of blood flow into the flap. Japanese white rabbit was used (n = 7) for this study. The amount of blood flow of jejunal and latissimus dorsi muscle (LD) flaps was measured while removing the distal portion of the flap sequentially. Conductance at each time was calculated from blood pressure and blood flow volume. The tissue volume at each time was also measured. The correlation between conductance and volume was analyzed using a linear mixed model. Immunohistochemical evaluation of microvessel densities (MVD) in these tissues was als...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

High-flow nasal cannula therapy for acute respiratory failure in patients with interstitial pneumonia: a retrospective observational study.
Authors: Omote N, Matsuda N, Hashimoto N, Nishida K, Sakamoto K, Ando A, Nakahara Y, Nishikimi M, Higashi M, Matsui S, Hasegawa Y Abstract High-flow nasal cannula (HFNC) oxygen is a therapy that has demonstrated survival benefits in acute respiratory failure (ARF). However, the role of HFNC in ARF due to interstitial pneumonia (IP) is unknown. The aim of this study was to compare the effects of HFNC therapy and non-invasive positive pressure ventilation (NPPV) in ARF due to IP. This retrospective observational study included 32 patients with ARF due to IP who were treated with HFNC (n = 13) or NPPV (n = 19). The cl...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Intervention efficacy for eliminating patient misidentification using step-by-step problem-solving procedures to improve patient safety.
This study aimed to evaluate the efficacy of interventions to reduce patient misidentification incidents classified as level 2 and over (adverse events occurred for patients) with the step-by-step problem-solving method. All incidents related to patient misidentification were selected, and relevant information was collected from the original electronic incident reports. We then conducted an eight-step problem-solving process with the aim of reducing patient misclassification and improving patient safety. Step 1: the number of misidentification-related incident reports and the percentage of these reports in the total incide...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Maternal exposure to environmental endocrine disruptors during pregnancy is associated with pediatric germ cell tumors.
This study explores the relationship between EEDs and pediatric germ cell tumors (GCTs). A case-control study was conducted in 84 pediatric patients from 2014 to 2017, including 42 subjects with immature teratoma, yolk sac tumor, or germinoma, and 42 controls who experienced pneumonia or trauma. Serum PFASs, including PFBS, PFHpA, PFHxS, PFOA, PFOS, PFNA, PFDA, PFUA, PFOSA, and PFDoA, were measured in each subject, and their history of possible EED exposure was reviewed. Six of the 10 measured PFASs were significantly increased in the GCT group relative to the control group. With respect to lifestyle history, only PFHxS le...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Different factors are associated with conventional adenoma and serrated colorectal neoplasia.
Authors: Zorron Cheng Tao Pu L, Rana K, Singh G, Nakamura M, Yamamura T, Koay DSC, Ovenden A, Edwards S, Ruszkiewicz A, Hirooka Y, Fujishiro M, Burt AD, Singh R Abstract Current data shows there are differences in factors associated with colorectal neoplasia based on geographical location and cultural settings. There are no studies focusing on the association between environmental factors and colorectal polyps in Australia. The aim of this study was to prospectively evaluate the association of various factors with different colorectal neoplasia histology. We utilized a simplified one-page questionnaire for patients...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

A proteome signature of umbilical cord serum associated with congenital diaphragmatic hernia.
In this study, we investigated serum biological profiles in neonates with CDH. For comprehensive investigation, umbilical cord serum samples were collected from isolated CDH cases (n = 4) and matched healthy controls (n = 4). Samples were analyzed using liquid chromatography-tandem mass spectrometry. A total of 697 proteins were detected; of them, 98 were identified as differentially expressed proteins. Among these differentially expressed proteins, complement C1q subcomponent showed the largest fold change, followed by complement C5. In the pathway enrichment analysis, the complement and coagulation cascades expressed the...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

<Editors' Choice> Initial experience with in vivo "endovascular shaping" technique that utilizes the vascular configuration for small cerebral aneurysm coiling.
<Editors' Choice> Initial experience with in vivo "endovascular shaping" technique that utilizes the vascular configuration for small cerebral aneurysm coiling. Nagoya J Med Sci. 2020 May;82(2):355-362 Authors: Hanaoka Y, Koyama JI, Yamazaki D, Miyaoka Y, Fujii Y, Nakamura T, Ogiwara T, Ito K, Horiuchi T Abstract Optimal shaping of a microcatheter tip is a key factor in cerebral aneurysm coiling. However, safe cannulation and stabilization of a microcatheter can be technically challenging with small aneurysms requiring precise microcatheter shaping. We devised a new microcatheter shaping ...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Multiple self-care behaviors and associated factors in community-dwelling patients with hypertension in Myanmar.
This study aimed to identify the prevalence of self-care behaviors and the associated factors among hypertensive patients in primary care in Myanmar. This cross-sectional study was conducted from April to May 2019 among 410 hypertensive patients in Myitkyina Township, Kachin State, Myanmar. Hypertensive patients aged 30-70 years old and being registered at the community health centers in Myitkyina Township were selected using multi-stage cluster random sampling. Self-care behaviors were measured by Hypertensive Self-Care Activity Level Effect (H-SCALE). Chi-square test and multiple logistic regression analysis were used to...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Growing skull fracture with an atypical mechanism: a case report.
Authors: Aoyama M, Joko M, Niwa A, Iwami K, Hara M, Osuka K, Miyachi S Abstract Growing skull fractures (GSFs) are well-known but rare causes of pediatric head trauma. They generally occur several months after a head injury, and the main lesion is located under the periosteum. We herein report a case involving a 3-month-old boy with GSF that developed by a different mechanism than previously considered. It developed 18 days after the head injury. A large mass containing cerebrospinal fluid and brain tissue was present within the periosteum. A good outcome was obtained with early strategic surgery. Injury to the inn...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Postoperative iatrogenic spinal cord herniation: three case reports with a literature review.
We present three cases of postoperative iatrogenic spinal cord herniation and present a literature review. Our data base included 32253 patients who underwent spinal surgery, and among these patients, 3 showed postoperative spinal cord herniation. Postoperative spinal cord herniation was observed in a 55-year-old man and a 60-year-old man. Both these patients underwent cervical laminoplasty for degenerative cervical myelopathy; however, intraoperative dural tear was reported. They presented with severe quadriplegia and sensory disorders at 8 years and 2 months after initial surgery. The third case of postoperative spinal c...
Source: Nagoya Journal of Medical Science - June 27, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Iatrogenic risk of osteonecrosis of the jaw? Bone substitutes for dental implants: a warning from Japan.
Authors: Hibi H Abstract Commercial bone substitutes that are widely used for bone augmentation for dental implants are predisposing factors in the development of osteonecrosis of the jaw (ONJ), overlooking this situation may lead to serious problems. Most of these materials are supplied as inorganic porous granules of calcium phosphate, which have characteristics that exceed the bone resorption ability of normal osteoclasts; therefore, they can be equally regarded as existing antiresorptive necrotic bony granules in the body, i.e., micro-ONJs. In addition, because dental implants directly contact the surrounding b...
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Association between locomotive syndrome and the Japanese version of the EQ-5D-5L in middle-aged and elderly people in Japan.
Authors: Tanaka S, Ando K, Kobayashi K, Seki T, Hamada T, Machino M, Ota K, Morozumi M, Kanbara S, Ito S, Ishiguro N, Hasegawa Y, Imagama S Abstract The Japanese version of the EuroQol 5 dimension, 5 level version (EQ-5D-5L) can now be used to quantitatively evaluate the health-related quality of life (QoL) in Japan. Locomotive syndrome (LS) is a concept advocated in Japan to describe a condition requiring care for musculoskeletal disorders. However, no detailed study on the relationship between this index and LS in Japanese health checkup has been reported. We aimed to evaluate the relationship between the Japanes...
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Outcome of cesarean scar pregnancy treated with local methotrexate injection.
Authors: Tam LM, Kotani T, Linh TM, Thu PTM, Khanh TV, Anh NTK, Nguyen NTT, Moriyama Y, Yamamoto E, Huy NVQ, Vinh TQ, Thanh CN, Kikkawa F Abstract Local injection of methotrexate (MTX) has been widely used for caesarean scar pregnancy (CSP), but the optimal candidate remains undetermined. The aim of this study is to determine the risk factors associated with treatment failure among patients who received a single dose of local MTX. This is a retrospective cohort study. Clinical information was compared between treatment success vs. failure groups. Risk factors related to treatment failure were also investigated with...
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Micro-computed tomography images of lung adenocarcinoma: detection of lepidic growth patterns.
Authors: Nakamura S, Mori K, Iwano S, Kawaguchi K, Fukui T, Hakiri S, Ozeki N, Oda M, Yokoi K Abstract Micro-computed tomography (µCT) provides extremely high-resolution images of samples and can be employed as a non-destructive inspection tool. Using µCT, we can obtain images comparable with microscopic images. In this work, we have attempted to take high-resolution images of the human lung using µCT. Compared to clinical high-resolution computed tomography (HRCT) images of living body (in-vivo imaging), we can obtain extremely high-resolution images by µCT of ex-vivo tissues (resected lung...
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

A prospective trial to evaluate treatment effects of a β-hydroxy-β-methylbutyrate containing nutrient for leakage at the anastomotic site after esophagectomy.
A prospective trial to evaluate treatment effects of a β-hydroxy-β-methylbutyrate containing nutrient for leakage at the anastomotic site after esophagectomy. Nagoya J Med Sci. 2020 Feb;82(1):33-37 Authors: Kanda M, Koike M, Fukaya M, Miyata K, Tanaka C, Kobayashi D, Hayashi M, Yamada S, Nakayama G, Murotani K, Fujiwara M, Nagino M, Kodera Y Abstract Anastomotic leakage after esophagectomy is associated with prolonged hospitalization and increased medical cost. Additionally, it sometimes leads to a fatal condition and impaired postoperative quality of life. During the process of wound healing...
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

The new bioabsorbable sheet for the sling method in immediate breast reconstruction with expander-implant: a study protocol for interventional prospective study.
This study will determine the safety and effectiveness of the sling method using a NEOVEIL sheet in Japanese women. PMID: 32273631 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Estimating cost of hospitalization for childbirth at a tertiary hospital in Mongolia.
Authors: Taazan B, Yamamoto E, Baatar B, Amgalanbaatar A, Kariya T, Saw YM, Hamajima N Abstract Health services for pregnancy and delivery at public health facilities are fully subsidized by the government in Mongolia. However, it has been reported that health financing, budget planning, and implementation processes are weak. Therefore, this study aims to estimate the costs per inpatient of vaginal delivery and cesarean section (C-section) by using data gathered from a tertiary hospital in Ulaanbaatar. Inpatient and financial data were collected from the Statistics and Finance, Economics Department of National Cent...
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

How emergency physicians choose chest tube size for traumatic pneumothorax or hemothorax: a comparison between 28Fr and smaller tube.
This study aimed to investigate how emergency physicians choose chest tube size and whether chest tube size affects patient outcome. We reviewed medical charts of patients who underwent chest tube insertion for chest trauma within 24 hours of admission in this retrospective, single-institution study. Patient characteristics, inserted tube size, risk of additional tube, and complications were evaluated. Eighty-six chest tubes were placed in 64 patients. Sixty-seven tubes were placed initially, and 19 additionally, which was significantly smaller than the initial tube. Initial tube size was 28 Fr in 38 and
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Risk factors for pulmonary infection after diagnostic bronchoscopy in patients with lung cancer.
In conclusion, endobronchial lesions and a larger lesion size are independent risk factors for the incidence of infections following bronchoscopic biopsy in patients with lung cancer. PMID: 32273634 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Compatibility of magnetic resonance imaging in patients with orthopedic implants: manufacturer questionnaires.
Authors: Iwatsuki K, Yoneda H, Onishi T, Ishii H, Kurimoto S, Yamamoto M, Tatebe M, Hirata H Abstract In clinical practice, surgeons have stated that magnetic resonance imaging (MRI) can be performed in patients with titanium alloy implants. However, manufacturers and distributors of many implants may not comply with this common practice. As such, this study aimed to investigate manufacturers' views on MRI use in patients fitted with their implants. The questionnaire survey was conducted between May and August 2018. Is your product compatible with MRI? ( ) Select from (1) to (3). In case of (1) or (2), up to ( ) Te...
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

<Editors' Choice> Stanniocalcin-1 mRNA expression in soft-tissue tumors.
Authors: Yamagishi T, Kawashima H, Ogose A, Ariizumi T, Oike N, Sasaki T, Hatano H, Endo N Abstract Stanniocalcin-1 (STC1) is a glycoprotein that was originally identified as a calcium-regulating hormone in bony fish, and that has been shown to also critically mediate cell growth, proliferation and differentiation, etc. in humans. Increased STC1 expression levels have been previously detected in different human cancer samples, such as those isolated from lung, breast, ovary, colon, pancreas, and liver tumors; thus, the present study evaluated STC1 expression in various soft-tissue tumors. STC1 mRNA isolated from 16...
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

<Editors' Choice> Efficacy of pectoral nerve block type-2 (Pecs II block) versus serratus plane block for postoperative analgesia in breast cancer surgery: a retrospective study.
This study suggests that Pecs II block prevents short-term post-BCS pain better than serratus plane block. However, further studies are needed in order to support this finding. PMID: 32273637 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

A comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between IgG4-related disease with bilateral hilar lymphadenopathy and sarcoidosis.
In conclusion, significant differences were observed in the FDG accumulation patterns and SUVmax values of the hilar lymph nodes between IgG4-RD with BHL and sarcoidosis, although both diseases develop through the lymphatic routes of the lungs and are frequently associated with BHL. PMID: 32273638 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Disease frequency among inpatients at a tertiary general hospital in Lao PDR.
This study aimed to report frequencies of the main cause of admission among inpatients of a tertiary general hospital (Mittaphab Hospital) in Vientiane. Subjects were inpatients who were admitted from January 3 to February 2 in 2017. The dataset were made as a pilot run to establish hospital statistics. The data on sex, age, address (province), dates of admission and discharge, and main diagnosis were collected from paper-based medical charts. International Classification of Diseases 10 was applied for classifying the main diagnosis. During the 1-month period, 1,201 inpatients (637 males and 564 females) were admitted, inc...
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Repair of temporal branch of the facial nerve with novel polyglycolic acid-collagen tube: a case report of two cases.
Authors: Nakamura Y, Takanari K, Ebisawa K, Kanbe M, Nakamura R, Kamei Y Abstract Autologous nerve transplantation has been the gold standard in the treatment of facial nerve injury, however it has not been achieved satisfactory result and needs donor sacrifice. A polyglycolic acid collagen conduit (Nerbridge, Toyobo Co., Japan) has the potential to compare to or exceed autologous nerve grafts in promoting nerve regeneration. Here we report two cases of traumatic temporal facial nerve injury repairs with Nerbridge. The severed temporal branch of the facial nerve was repaired with Nerbridge conduits in two patients....
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device.
Authors: Hiraiwa H, Okumura T, Shimizu S, Arao Y, Oishi H, Kato H, Kuwayama T, Yamaguchi S, Haga T, Yokoi T, Kondo T, Sugiura Y, Kano N, Watanabe N, Fukaya K, Furusawa K, Sawamura A, Morimoto R, Fujimoto K, Mutsuga M, Usui A, Murohara T Abstract We herein report the long-term changes in cardiac function and pathological findings after successful explantation of a left ventricular assist device in a 42-year-old patient with anthracycline-induced cardiomyopathy with reworsening heart failure. Endomyocardial biopsy samples revealed that the cardiomyocyte diameter decreased and collagen volume fraction increased just a...
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Pediatric nasopharyngeal cancer with repeated oligometastases involving the bone, liver and distant lymph nodes who achieved cure after radiotherapy.
We report a NPC case in a pediatric patient with repeated oligometastases involving the bone, liver and distant lymph nodes who achieved 10-year disease free status after initial chemotherapy and radiotherapy to all the metastases. This very rare case demonstrated that radiotherapy to oligometastatic lesions have a potential to cure repeated oligometastases which involved multiple-organ metastases in a pediatric NPC with stage IVc. PMID: 32273642 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Temporal arteritis with focal pachymeningitis: a deceptive association.
We present our case, discuss the management and summarize a review of literature about focal pachymeningitis along with temporal arteritis which was managed successfully with steroids and Toclizumab. PMID: 32273643 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - April 12, 2020 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Congenital esophageal stenosis: a rare malformation of the foregut.
Authors: Brzački V, Mladenović B, Jeremić L, Živanović D, Govedarović N, Dimić D, Golubović M, Stoičkov V Abstract Congenital esophageal stenosis (CES) is a type of esophageal stenosis, and three histological subtypes (tracheobronchial remnants, fibromuscular thickening or fibromuscular stenosis, and membranous webbing or esophageal membrane) are described. Symptoms of CES usually appears with the introduction of the semisolid alimentation. Dysphagia is the most common symptom, but esophageal food impaction, respiratory distress or failure to thrive can be clinical manifestations of CES. Wide spectrum of d...
Source: Nagoya Journal of Medical Science - December 20, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Routine presternotomy extracorporeal circulation for redo surgery.
We report our 10-year experience of performing presternotomy ECC for cardiac reoperation and the clinical results. Fifty-seven consecutive cardiac reoperations involving resternotomy were performed between January 2006 and December 2015. ECC was established prior to median sternotomy in all patients. Two patients sustained injury to the right ventricle during sternotomy. Eleven patients sustained injury to the mediastinal structures during dissection (right atrium in 3; superior vena cava in 2; inferior vena cava in 3; left internal thoracic artery in 1; and saphenous vein graft in 2 patients). Longer ECC time and greater ...
Source: Nagoya Journal of Medical Science - December 20, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Spirituality in older men living alone near the end-of-life.
Authors: Hirakawa Y, Chiang C, Yasuda K, Iwaki Y, Andoh H, Aoyama A Abstract Older people living alone has been reported to be socially isolated and suffering from loneliness. Although spiritual care is a core element of end-of-life care for older people, a clear-cut definition of spirituality has not been established yet. It remains unclear how spirituality is perceived by heath care professionals and how spiritual care is delivered in the end of life. Also, most of the previous studies on perspective of older people living alone targeted women, while very few researches shed light on the experience of older men. ...
Source: Nagoya Journal of Medical Science - December 20, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Predictors of denosumab efficacy in treating osteoporosis in patients with rheumatoid arthritis: a Japanese multicenter study.
In conclusions, denosumab increased BMD in RA patients with osteoporosis. The combined use of biologics and denosumab may provide useful treatment options. PMID: 31849375 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - December 20, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Nasal patency as a factor for successful transnasal endoscopy.
In conclusion, the most difficult problem during transnasal endoscopy was pain, which was related to nasal patency. We successfully demonstrated the clinical significance of nasal patency in determining the side of insertion for transnasal endoscopy. PMID: 31849376 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - December 20, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Guiding patients to appropriate care: developing Japanese outpatient triage nurse competencies.
Authors: Usui M, Yamauchi T Abstract Japanese patients often seek hospital services without a primary provider's referral. A triage nurse who is the initial point of contact for a patient is challenged with the task of expertly evaluating the urgency of the condition and selecting the appropriate specialty service for every patient's needs. A triage nurse must also recognize any conditions requiring emergency medical services instead of a specialty outpatient service. A modified Delphi method was used to establish expert consensus regarding triage nursing competencies for secondary and higher-level health care faci...
Source: Nagoya Journal of Medical Science - December 20, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies.
Authors: Kajikawa S, Imai N, Okachi S, Yatsuya H, Souma T, Watanabe T, Goto Y, Minezawa T, Hashimoto N, Imaizumi K, Hasegawa Y Abstract Although endobronchial ultrasound guided transbronchial biopsy (TBB) with a guide sheath (EBUS-GS) is widely used for diagnosis of peripheral pulmonary lesions, the diagnostic contribution of cytology (bronchial brushing, bronchial washing and biopsy forceps rinse) has not been established. To determine the diagnostic contribution of cytological examination to EBUS-GS-TBB, we reviewed medical records of patients with lung malignancies who had undergone TBB with EBUS-GS (EBUS-GS gro...
Source: Nagoya Journal of Medical Science - December 20, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Tibial rotational alignment after opening-wedge and closing-wedge high tibial osteotomy.
In this study, two considerations were examined. The first was the change in rotation angle, which was defined by TERA noted before and after the operation. The second was the relationship between the correction angle of the osteotomy and the rotation angle change of the distal tibia. The first was evaluated using the paired-Student's t-test, while the second was analyzed with Pearson's correlation coefficient. In the OWHTO group, the mean TERA was 21.4± 7.0° preoperatively and 20.2 ± 8.0° postoperatively, but no significant difference was seen between pre- and post-operation measurements (p = 0.21). ...
Source: Nagoya Journal of Medical Science - December 20, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Factors influencing blood flow resistance from a large internal carotid artery aneurysm revealed by a computational fluid dynamics model.
Authors: Imai T, Izumi T, Isoda H, Ishiguro K, Mizuno T, Tsukada T, Kropp A, Ito M, Nishihori M, Ishida M, Tamari Y, Wakabayashi T Abstract Hyperperfusion syndrome occurs after treatment of a large or giant cerebral aneurysm. Recently, flow-diverter stent placement has emerged as an effective treatment method for a large cerebral aneurysm, but postoperative ipsilateral delayed intraparenchymal hemorrhage occurs in a minority of cases. The mechanism underlying delayed intraparenchymal hemorrhage is not established, but one possibility is hyperperfusion syndrome. The incidence of delayed intraparenchymal hemorrhage a...
Source: Nagoya Journal of Medical Science - December 20, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Insomnia affects future development of depression in workers: a 6-year cohort study.
Authors: Nishitani N, Kawasaki Y, Sakakibara H Abstract The purpose of this study was to investigate the relationship between insomnia and future risk of developing depression. This was a 6-year cohort survey from 2011 to 2017. A questionnaire was conducted with male workers in a manufacturing industry. The questions included the Center for Epidemiologic Studies Depression Scale (CES-D) for evaluating depression and the Athens Insomnia Scale (AIS) for rating insomnia. Data from 1,332 daytime workers aged less than 60 years who had no depressive symptoms at baseline were analyzed. The risk of developing depression i...
Source: Nagoya Journal of Medical Science - December 20, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research