Comparison between rectus sheath block with 0.25% ropivacaine and local anesthetic infiltration with 0.5% ropivacaine for laparoscopic inguinal hernia repair in children.
Authors: Tamura T, Kaneko K, Yokota S, Kitao T, Ando M, Kubo Y, Nishiwaki K Abstract This randomized, observer-blinded prospective study aimed to compare the postoperative analgesic effects of ultrasound-guided rectus sheath block with those of local anesthetic infiltration of the surgical field in children undergoing inguinal hernia repair. Children aged 2 to 14 years, scheduled for elective single-incision laparoscopic percutaneous extraperitoneal closure, were randomly allocated to receive ultrasound-guided rectus sheath block (group R) or local anesthetic infiltration of the surgical field (group L). In group R...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

High-dose-rate intracavitary brachytherapy for recurrent cervical cancer in the vaginal stump after hysterectomy.
In conclusion, HDR-BT was an effective treatment modality for patients with cervical cancer recurrence in the vaginal stump. PMID: 31579327 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Cilostazol use is associated with FIM cognitive improvement during convalescent rehabilitation in patients with ischemic stroke: a retrospective study.
Authors: Senda J, Ito K, Kotake T, Kanamori M, Kishimoto H, Kadono I, Nakagawa-Senda H, Wakai K, Katsuno M, Nishida Y, Ishiguro N, Sobue G Abstract Cilostazol is a phosphodiesterase III-inhibiting antiplatelet agent that is often used to prevent stroke and peripheral artery disease, and its administration has shown significant improvements for cognitive impairment. We investigate the potential of cilostazol for reducing or restoring cognitive decline during convalescent rehabilitation in patients with non-cardioembolic ischemic stroke. The study sample included 371 consecutive patients with lacunar (n = 44) and ath...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Participation rate determines completion rate for specific health guidance as implemented by public health insurers.
This study aimed to clarify factors affecting the rate using questionnaire survey, which was conducted by mail between December 2016 and January 2017 for insurers in the Tokai Region of Japan. The subjects were 69 insurers and the collection rate was 25.1%. The SHG participation rate was 26.3%, and the SHG completion rate was even lower (23.6%) than the participation rate. The rate was significantly lower in dependents than in insured persons. Multiple regression analysis with SHG completion rate as the dependent variable indicated that only "participation rate in SHG" was positively related to completion rate. W...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Retrospective analysis of hypofractionated stereotactic radiotherapy for tumors larger than 2 cm.
Authors: Koide Y, Tomita N, Adachi S, Tanaka H, Tachibana H, Kodaira T Abstract Stereotactic radiosurgery for large brain metastases (BM) not amenable to surgical resection is associated with limited local control and neurotoxicity, while hypofractionated stereotactic radiotherapy (HFSRT) has emerged as a promising option. We retrospectively evaluated 61 patients with BM larger than 2 cm in the maximum diameter, who were treated with HFSRT (mainly 35 Gy/5 fractions) in our center between 2006-2016, focusing on the effect of BM size on outcomes. Eligible patients were divided according to the maximum BM diameter (gr...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Concurrent chemoradiotherapy with intravenous cisplatin and docetaxel for advanced oral cancer.
Authors: Sato K, Hayashi Y, Watanabe K, Yoshimi R, Hibi H Abstract Concurrent chemoradiotherapy (CCRT) is a common treatment for advanced oral cancer, and its efficacy has been reported in many reviews. We have performed concurrent CCRT with intravenous cisplatin and docetaxel in patients with advanced oral cancer. The purpose of this report was to evaluate this treatment and to compare the outcome of this treatment with that of standard CCRT treatments for advanced head and neck cancer using intravenous administration. The patients were treated for primary advanced oral squamous cell carcinoma in our department be...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Tegafur and 5-fluorouracil levels in tears and changes in tear volume in long-term users of the oral anticancer drug S-1.
Authors: Kuriki R, Hata T, Nakayama K, Ito Y, Misawa K, Ito S, Tatematsu M, Kaneda N Abstract Eye problems are an adverse reaction sometimes found in chemotherapy. Although not life-threatening, they can reduce patients' quality of life. The highest incidence of eye problems is reported for the combination anticancer drug S-1 (tegafur-gimeracil-oteracil), and methods to prevent or treat the eye problems caused by this drug are presently lacking. To determine early detection methods and treatment for adverse ocular reactions, we measured changes in tear volume and levels of tegafur (FT) and 5-fluorouracil (5-FU), an...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

<Editors' Choice> Renewed Japanese spirometric reference variables and risk stratification for postoperative outcomes in COPD patients with resected lung cancer.
Authors: Okada Y, Hashimoto N, Iwano S, Kawaguchi K, Fukui T, Sakamoto K, Wakai K, Yokoi K, Hasegawa Y Abstract Although the lower limit of normal (LLN) of FEV1/FVC detects at-risk patients for postoperative outcomes among Japanese chronic obstructive pulmonary disease (COPD) patients with resected lung cancer, there was a lack of a Japanese reference equation to calculate the LLN of FEV1/FVC. Renewed Japanese spirometric reference variables might enable us to verify clinical impact of the LLN of FEV1/FVC among the Japanese population. To evaluate the clinical impact of the LLN of FEV1/FVC by using this renewed ref...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Tradescantia pallida extract inhibits biofilm formation in Pseudomonas aeruginosa.
In this study, we investigated the effects of aqueous Tradescantia pallida extract on Pseudomonas aeruginosa growth and biofilm formation. Aqueous Tradescantia pallida extracts significantly inhibited both bacterial growth and biofilm formation. However, methanolic Tradescantia pallida extracts inhibited neither. Aqueous Tradescantia pallida extracts were deactivated by heating but were not deactivated by light exposure. The ingredients retained the inhibitory effect on the bacterial growth and biofilm formation after ultrafiltration of aqueous Tradescantia pallida extract. Furthermore, polyphenol-rich Tradescantia pallida...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Relationship between rheumatoid arthritis and locomotive syndrome: validation of the 25-question Geriatric Locomotive Function Scale in patients with rheumatoid arthritis.
In conclusion, our findings suggest that some patients with RA in remission may have LS, as well as the need to consider appropriate interventions for such patients. PMID: 31579335 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

MRI-guided percutaneous needle biopsy with 1.2T open MRI: study protocol for a prospective feasibility study (SCIRO-1701).
Authors: Matsui Y, Sakurai J, Hiraki T, Okamoto S, Iguchi T, Tomita K, Uka M, Gobara H, Kanazawa S Abstract There has been growing interest in magnetic resonance imaging (MRI)-guided interventional procedures such as percutaneous needle biopsy. Although open MRI is preferable for MRI-guided procedures in terms of patient accessibility, its inferior imaging capability due to lower field strength is a substantial limitation. In this situation, the high-field (1.2T) open MRI has recently become available. This novel MRI system is expected to provide excellent image quality as well as good patient accessibility, potent...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Otological aspects of Fabry disease in patients with normal hearing.
Authors: Wang F, Yamamoto H, Yoshida T, Sugimoto S, Teranishi M, Tsuboi K, Sone M Abstract We investigated the otological aspects of Fabry disease (FD) in patients with normal hearing. Forty-one patients (21 men, 20 women) with bilaterally normal hearing were recruited, and their otological symptoms and hearing evaluations, which included pure tone audiometry (PTA) and distortion product otoacoustic emission (DPOAE), were investigated. Ten of the 21 male (47.6%) and eight of the 20 female (40.0%) patients had otological symptoms, of which tinnitus was the most frequent. Cardiac dysfunction was more frequently obser...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Polymorphisms in CPT1B and CPT2 have no significant effect on plasma carnitine levels in Japanese cancer patients.
Authors: Hishida A, Watanabe R, Hattori Y, Okugawa Y, Shirai Y, Miki C Abstract Treatment of cancer patients undergoing chemotherapy with L-carnitine (LC) supplementation is becoming increasingly popular in the clinic. The present study aimed to examine the possible effects of polymorphisms in CPT1B and CPT2 (CPT1B G320D, S427C, c.282-18 C>T, and p.E531K, and CPT2 V368I) on the plasma concentration of carnitine in humans. The subjects were the 218 participants of the Iga Cohort Study. Differences in plasma-free carnitine levels by genotype were examined. Genotyping was conducted by polymerase chain reaction with...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Frequency of forest walking is not associated with prevalence of hypertension based on cross-sectional studies of a general Japanese population: a reconfirmation by the J-MICC Daiko Study.
This study aimed to reconfirm the presence or absence of an association between the frequency of forest walking and prevalence of hypertension in a Japanese population. This J-MICC Daiko Study was conducted targeting residents in Nagoya City. A total of 5,109 participants (1,452 men and 3,657 women; age, mean ± standard deviation: 52.5 ± 10.3 years) were included in the analysis. Age-adjusted blood pressure level by frequency of forest walking was not significant. After adjusting for age and lifestyle, the adjusted odds ratios (aORs) of the most frequent group (n=88, 1.7%; once a week or more group) relative ...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

An overview of ethical review committees in Japan: examining the certification applications of ethical review committees.
Authors: Iijima Y, Ogasawara K, Toda S, Takano T Abstract The survey involves examining the applications from 142 institutions that have consented to make available all certification applications from 2015 and 2016 to a research project for building a certification system for an ethics committee run by the Agency for Medical Research and Development. The number of certified institutions is 20 (14.1%). In the applications from uncertified institutions, there are cases in which requirements of ethics guidelines are unmet, and there is insufficient information provided on regulation and procedure. An analysis of the c...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Multiple ruptured cerebral aneurysms at the National Hospital of the Kyrgyz Republic between 2008 and 2014: a departmental summary.
Authors: Yrysov K, Tursunov D, Reyer JA, Yamamoto E, Yrysova M, Hamajima N Abstract Despite the rapid progress of vascular neurosurgery with the development of microsurgical and endovascular techniques, the optimal strategy for surgical treatment of multiple cerebral aneurysms has not yet been developed. The indications for choosing one-stage or multi-stage surgery remain unsolved. This is a summary of the departmental routine reports at the Clinic of Neurosurgery, National Hospital of the Kyrgyz Republic. Subjects were 235 patients (124 males and 111 females) with ruptured multiple cerebral aneurysms admitted to t...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Fatal case of TAFRO syndrome associated with over-immunosuppression: a case report and review of the literature.
Authors: Matsuhisa T, Takahashi N, Nakaguro M, Sato M, Inoue E, Teshigawara S, Ozawa Y, Kondo T, Nakamura S, Sato J, Ban N Abstract TAFRO syndrome is a novel disease concept characterized by Thrombocytopenia, Anasarca, myeloFibrosis, Renal dysfunction, Organomegaly, multiple lymphadenopathy and a histopathological pattern of atypical Castleman's disease. A 58-year-old man was diagnosed as TAFRO syndrome by clinical and histopathological findings. After receiving intensive immunosuppressive therapy, his thrombocytopenia and anasarca had not improved. He developed complications such as methicillin-resistant Staphyloc...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Ileal conduit necrosis after total pelvic exenteration for recurrence of gastrointestinal stromal tumor.
We report a case of ileal conduit necrosis after total pelvic exenteration for recurrence of gastrointestinal stromal tumor. A 47-year-old man was diagnosed with recurrence of gastrointestinal stromal tumor adjacent to the prostate after abdominoperineal resection 10 years prior. With imatinib administration for 18 months, the local recurrence decreased in size but did not separate from the prostate. We performed urinary diversion with conventional total pelvic exenteration. Ileal conduit necrosis was suspected the following day and emergency surgery was performed. The serosa of the ileal conduit showed segmental necrosis ...
Source: Nagoya Journal of Medical Science - October 4, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Joint Degree Program for Graduate Students at the Nagoya University Graduate School of Medicine.
This article reports the issues specific to counterpart medical schools, including student's recruitment, the curriculum, and the general differences between each schools. JDPs are not only important for educational collaboration, but also as a strategy to encourage international research collaboration, which is a core criterion to a university's world-ranking reputation. Acquiring knowledge about educational strategies that are implemented in different foreign medical schools represents a unique opportunity to improve our own curriculum. PMID: 31239586 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Epidemiological overview of metastatic ovarian carcinoma: long-term experience of TOTSG database.
Authors: Kajiyama H, Suzuki S, Utsumi F, Nishino K, Niimi K, Mizuno M, Yoshikawa N, Kawai M, Oguchi H, Mizuno K, Yamamuro O, Shibata K, Nagasaka T, Kikkawa F Abstract Malignant ovarian neoplasm is one of the most lethal malignancies among cancers of the female reproductive system. Occasionally, these tumors originate from non-ovarian organs as metastatic lesions since the ovary is a frequent metastatic target of many cancers. However, there limited clinical information on metastatic ovarian carcinoma (MOC) and its hallmarks are unknown. During the period of 1986-2015, 4,284 patients with malignant ovarian neoplasm ...
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Health-related behavior of the people who neglect the specific health guidance for metabolic syndrome control.
Authors: Hirakawa Y, Chiang C, Yasuda Uemura M, Aoyama A Abstract In 2008, Japan introduced a metabolic syndrome screening and intervention program specifically targeting individuals aged 40 to 74 years of age. However, the consultation and follow-up rates for the intervention are still low. The present study aims to identify characteristics of health-related behavior of the people who neglect it. We conducted a group interview targeting public health nurses and qualified dieticians of "A" prefectural branch office of the Japan Health Insurance Association who were regularly involved in performing the int...
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Effect of an artificial ring on mitral valve function.
Authors: Yokote J, Araki Y, Saito S, Hasegawa H, Usui A Abstract Differences of the effect of annuloplasty rings on the mitral annulus and leaflets, and differences between types of annuloplasty rings are not well known. We analyzed annular motion and leaflet movement with a rigid or flexible ring and without a ring using an isolated swine working heart model. Hearts of 10 swine (weight: 40-50 kg) were used for a rigid ring (n=5) and a flexible ring (n=5). Four ultrasound crystal tips were fixed around the annulus and an annuloplasty ring was implanted in the isolated heart. In the working heart mode, measurement o...
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Experimental study of coil delivery wire insertion force in intracranial aneurysm embolization: force discrepancy generated inside the microcatheter through that coil delivery wire passes.
In conclusions, as the loading force increases, the force discrepancy increases, and it means that the coil insertion force that the interventionist feels at his fingertips also increases. This force discrepancy is impacted by the delivery wire properties and microcatheter curvature. PMID: 31239590 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Design of a prospective multicenter randomized controlled trial evaluating the effects of gastric lavage on coffee-ground emesis in neonates: study protocol.
Authors: Maeda T, Sato Y, Hirakawa A, Nakatochi M, Kinoshita F, Suzuki T, Ichimura S, Ito R, Kudo R, Suzuki M, Hoshino S, Sugiyama Y, Muramatsu H, Kidokoro H, Kawada JI, Takahashi Y, Nagoya Collaborative Clinical Research Team Abstract Neonates who swallow a considerable amount of maternal blood may exhibit vomiting and suckling disorder during the first few days of the postnatal period. Some clinicians treat these neonates with gastric lavage (GL) to prevent vomiting and the establishment of enteral feeding empirically, but there was no study assessing the effect of GL for neonates with coffee-ground emesis. We de...
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Phase II study of chemoradiotherapy combined with gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic ductal adenocarcinoma (NUPAT 05 Trial): study protocol for a single arm phase II study.
This study will show the efficacy and safety of chemoradiotherapy combined with GnP. PMID: 31239592 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

The utility of ultrathin endoscopy with flexible spectral imaging color enhancement for early gastric cancer.
We examined the color difference between early gastric cancer and the surrounding mucosa. To examine the relationship between the color difference and the vessel density, we also measured the difference in vessel density using pathologic specimens stained with hematoxylin and eosin. The Likert score of WF-UE was significantly higher than those of the other three methods (p
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Exploration of coping styles in male patients with head and neck cancer: a prospective cohort study.
Authors: Sato N, Kimura H, Adachi Y, Nishio N, Ando M, Tokura T, Nagashima W, Kishi S, Yamauchi A, Yoshida K, Hiramatsu M, Fujimoto Y, Ozaki N Abstract Majority of head and neck cancer (HNC) patients are male, and more than 85% of patients with HNC have the habit of smoking and drinking. Due to the specific demographic characteristics, HNC patients are anticipated to have specific coping styles, affecting psychological distress, survival, and quality of life. We explored the subscales of the Mental Adjustment to Cancer (MAC) Scale in male patients with HNC, and then examined the correlation between revised subscale...
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Fibrinogen levels measured by the dry hematology method are lower than those measured by the Clauss method under a high concentration of heparin.
Authors: Suzuki S, Tamura T, Hasegawa K, Maeda S, Mori R, Kainuma M, Adachi Y, Nishiwaki K Abstract The activity of fibrinogen has been reported to decrease soon after the onset of major bleeding and to be an important determinant of the final extent of bleeding and postoperative outcome. A device that measures the perioperative fibrinogen level using the dry hematology (DH) method has recently become available. The aim of this study was to compare perioperative fibrinogen levels measured by the DH method with those measured by the conventional Clauss method and to assess the effects of heparin on these measurement...
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Cognitive function measured with the Revised Hasegawa's Dementia Scale among elderly individuals in Lao PDR.
This study aimed to investigate the cognitive function among elderly individuals who lived at their homes with family in Lao PDR. Participants were elderly individuals aged 60 years or over registered with the local government in urban (Vientiane capital; VC) and rural areas (Khammouane province; KP). Those with serious mental/physical diseases, those who could not walk by themselves, or those who could not speak the Lao language were excluded. The information was collected through interviews with the participants and their family members. A newly developed Lao version of the Revised Hasegawa's Dementia Scale (HDS-R) was a...
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Evaluation of intra-tumoral blood feeding to predict the effect of induction therapy in patients with locally advanced lung cancer.
Authors: Kawaguchi K, Fukui T, Goto M, Nakamura S, Hakiri S, Ozeki N, Kato T, Mori S, Hashimoto K, Iwano S, Yokoi K Abstract There is little known about predictors of the effects of induction therapy in locally advanced lung cancer, including superior sulcus tumors. We analyzed whether intra-tumoral blood feeding could predict a pathologic complete response (pCR). Patients who underwent induction therapy followed by surgery for locally advanced lung cancer were retrospectively reviewed. The intra-tumoral blood feeding was defined by the CT value (HU, Hounsfield unit), which was calculated by subtracting the non-enh...
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Gatekeeping in an inpatient rehabilitation facility to reduce morbidity and mortality due to cardiac disease: screening program using of BNP and ECG Auto-diagnosis.
Authors: Kano N, Kato T, Tomohara T, Futamura Y, Yoshida S, Okumura T, Maeda K, Murohara T, Oda K Abstract The Kaifukuki-Rehabilitation Ward (KRW) is a type of inpatient rehabilitation facility in Japan. In the KRW of our institute, mortality and frequency of emergency referrals in 2013 were rather high, 2.6% and 4.3%, respectively. We aimed to investigate the usefulness of an original gatekeeping system to reduce mortality and morbidity from cardiac complications, and to improve the quality of medical care in the KRW. A total of 370 consecutive patients admitted to the KRW of Kobayashi Memorial Hospital between 1 ...
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Clinical outcomes of rotational atherectomy in severely calcified in-stent restenosis: a single-center, retrospective study.
In conclusion, clinical outcomes of rotational atherectomy for severely calcified ISR were unfavorable despite a high success rate and acceptable acute gain in lumen diameter. PMID: 31239599 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

A long-term survival case of Sister Mary Joseph's nodule caused by colon cancer and treated with a multidisciplinary approach.
Authors: Iwata Y, Kinoshita T, Kimura K, Komori K, Hayashi D, Akazawa T, Shigeyoshi I, Tsutsuyama M, Kawakami J, Ouchi A, Natsume S, Uemura N, Ito Y, Misawa K, Senda Y, Abe T, Ito S, Tajika M, Yatabe Y, Yoshida K, Shimizu Y Abstract Umbilical metastasis from intra-abdominal or pelvic malignancy, which is called Sister Mary Joseph's nodule (SMJN), is rare, and it has a poor prognosis. Its most common primary sites are the stomach and ovaries. SMJN caused by colon cancer is uncommon. A 42-year-old woman visited local clinics with complaints of an umbilical mass. After a detailed examination, she was diagnosed with pe...
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Use of the autologous spiral vein graft: a two-stage iliac bypass in a potentially fatal case of pelvic trauma and contaminated tissues.
We report the use of a spiral venous graft (SVG) in a case of two-stage bypass aimed at saving first life, and then the extremity. Severe open and contaminated injury was present in the lower abdomen and pelvic region of 29-year-old woman brought to the emergency department following a traffic accident. The patient was in shock, and was taken for emergency surgery jointly with the relevant departments. Interposition bypasses with synthetic graft were performed in the first stage. The synthetic grafts were subsequently removed due to problems developing secondary to infection at subsequent follow-up, and revascularization w...
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Pre-surgical sunitinib treatment enabling nephron-sparing surgery in a patient with renal cell carcinoma in a solitary kidney.
Authors: Tochigi K, Funahashi Y, Mori A, Matsukawa Y, Kato M, Gotoh M Abstract A 55-year-old man with a solitary kidney was diagnosed with an 8.5 cm renal cell carcinoma in the right kidney without metastasis. Twenty five months of sunitinib treatment reduced the tumor from 8.5 to 5.5 cm and enabled nephron-sparing surgery. He has no evidence of recurrence 58 months after the surgery. PMID: 31239602 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Outbreak detection of influenza-like illness in Prey Veng Province, Cambodia: a community-based surveillance.
This study showed that the ILI outbreak might be caused by seasonal influenza A/H1N1 pdm09 spread from person to person. Poor living conditions and poor hygiene and sanitation practices were environmental factors that caused the outbreak. As the CBS system was unable to identify this epidemic, it needs to be improved. PMID: 31241062 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - June 28, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

<Editors' Choice> Meddling with meddlers: curbing regulatory T cells and augmenting antitumor immunity.
Authors: Kochin V, Nishikawa H Abstract CD4+ regulatory T cells (Tregs) expressing the transcription factor forkhead box P3 (FoxP3) play an important role in self-tolerance and immune homeostasis. Tregs have evolved to protect the host from aberrant immune responses against self-components and collateral damages occurring in the process of defense against invading pathogens by softening immune responses. However, they turned to be a scourge in malignant tumors by not only allowing and promoting tumor growth but also suppressing effective antitumor actions, both inherent (host's immune surveillance) and extrinsic (a...
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

<Editors' Choice> Pulmonary Hypertension: Diagnosis, Management, and Treatment.
Authors: Kondo T, Okumura N, Adachi S, Murohara T Abstract Pulmonary hypertension (PH) is a hemodynamic state that is characterized by a resting mean pulmonary artery pressure ≧ 25 mmHg. The common forms of PH are pulmonary arterial hypertension (PAH), chronic thromboembolic pulmonary hypertension (CTEPH), PH caused by left-heart disease, and PH due to lung disease. Previously regarded as untreatable, the treatment of PAH has dramatically advanced since the introduction of the drug epoprostenol in 1999, with three-year survival rates improving from 30%-40% to over 85%. Drugs available for the specific treatment o...
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Mass media exposure and childhood diarrhea: a secondary analysis of the 2011 Bangladesh Demographic and Health Survey.
This study examined whether mother's exposure to mass media was associated with child's diarrhea, and with the diarrhea management practiced by their mothers. Data on 7,068 women, whose youngest child was under five years old, were extracted from the Bangladesh Demographic and Health Survey, 2011, together with information on the child. The outcome variables were an episode of diarrhea in the two weeks prior to the survey and diarrhea management practices; exposure to mass media was used as the major explanatory variable. They were descriptively summarized, and logistic regression analyses were performed. Television was fo...
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Quantitative Follow-Up Assessment of Patients with Interstitial Lung Disease by 3D-Curved High-Resolution CT Imaging Parallel to the Chest Wall.
Authors: Umakoshi H, Iwano S, Inoue T, Li Y, Nakamura K, Naganawa S Abstract We evaluated the progression of interstitial lung disease (ILD) by three-dimensional curved high-resolution computed tomography (3D-cHRCT) at a constant depth from the chest wall and compare the results to pulmonary function test (PFT) results on a follow-up assessment. We reviewed the patients with ILD who underwent HRCT and concurrent PFTs at least twice from April 2008 to December 2014. Forty-five patients with ILD were enrolled. 3D-cHRCT images of the lung at various depths from the chest wall were reconstructed, and total area (TA), h...
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Partial Identification of Amyloid- β Degrading Activity in Human Serum.
Partial Identification of Amyloid-β Degrading Activity in Human Serum. Nagoya J Med Sci. 2019 Feb;81(1):55-64 Authors: Mikawa R, Okuno A, Yoshimi T, Watanabe A, Maruyama M, Takikawa O Abstract The major hallmarks of Alzheimer's disease (AD) are the extracellular accumulation of pathological amyloid beta (Aβ) in the brain parenchyma and Aβ deposition in cerebral blood walls (cerebral amyloid angiopathy; CAA). Although CAA occurs in more than 80% of AD patients, the mechanisms of Aβ deposition and clearance around the vessel walls are unknown. We found Aβ-degrading activity in hu...
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Knowledge, attitude, and usage pattern of tobacco among high school students in Nay Pyi Taw, Myanmar.
This study indicated that the high school students knew about the ill effects of tobacco, but not about the Tobacco Product Law. Schools need to educate students and teachers about tobacco and the Tobacco Product Law and the enforcement of the law is also needed. PMID: 30962656 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Healthcare waste management at primary health centres in Mon State, Myanmar: the comparisons between hospital and non-hospital type primary health centres.
This study aims to assess the practice of HCWM at PHCs in Mon State, Myanmar. A cross-sectional study was conducted in all ten townships in Mon State, Myanmar. In total, 93 PHCs (71 non-hospitals and 22 hospitals) were selected using simple random sampling. The observational checklist which was developed based on the World Health Organization's standard guideline procedure of HCWM was used to determine the practice of HCWM at PHCs. Binary logistic regression was used for final data analysis. The burning in pits method was used as the final disposal method of healthcare waste in 78.5% of PHCs. Non-hospital type PHC were mor...
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Enhanced efficacy of histone deacetylase inhibitor panobinostat combined with dual PI3K/mTOR inhibitor BEZ235 against glioblastoma.
This study aimed to evaluate the efficacy of combination treatment of GBM with the histone deacetylase (HDAC) inhibitor panobinostat and dual phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor BEZ235. GBM cells were exposed to panobinostat and BEZ235 treatment alone or in combination, after which cell viability, proliferation and apoptosis were detected. Furthermore, the inhibitory mechanisms were investigated by Caspase-Glo assay, Western blot and qPCR analysis. We found that combination treatment with panobinostat and BEZ235 synergistically inhibited cell viability, markedly inhibited cel...
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Oral health-related quality of life among community dwelling middle-aged and older adults in an urban area in Magway region, Myanmar.
This study aims at describing oral health-related quality of life (OHRQoL) and determining its associated factors in a middle-aged and older adult community dwelling population in Myanmar. In a cross-sectional community survey, 633 individuals (men 55% and women 45%), aged 35-65 years, selected by multi-stage random sampling, responded to a structured questionnaire on the Oral Health Impact Profile-short form (OHIP-14), health status, health behavior and socio-demographic information. Participants had an overall mean score of 8.1(item mean=0.65) on the OHIP-14, 57.2% had impaired OHRQoL and 16.6% frequent impaired OHRQoL. ...
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Acetabular fracture non-union with pelvic discontinuity treated with two-stage total hip arthroplasty after intra- and extra-articular plate fixation.
Authors: Morita D, Seki T, Takegami Y, Kasai T, Higuchi Y, Ishiguro N Abstract Surgical intervention for the treatment of acetabular fracture non-union is often challenging. Here, we present a case of acetabular fracture non-union with pelvic discontinuity in a patient who underwent cemented total hip arthroplasty (THA) after intra- and extra-articular plate fixation. The case was a 70-year-old male with left T-shaped acetabular fracture non-union neglected for 5 months after the injury. The anterior and posterior columns were not healed, and the articular surface was displaced toward the medial side with a protrus...
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Factors associated with antenatal care visits in Afghanistan: secondary analysis of Afghanistan Demographic and Health Survey 2015.
This study aimed to identify the factors associated with ANC visits in Afghanistan. The dataset of the Afghanistan Demographic and Health Survey (AfDHS) 2015 were used for taking the socio-demographic factors, cultural factors, and the number of ANC visits. The subjects of this study were 18,790 women who had at least one live birth in the last five years, and 10,554 women (56.2%) had availed of at least one ANC visit. Most women were 20-29 years old (53.3%), poor (41.7%), had 2-4 children (43.9%), lived in rural areas (76.1%), and had no education (85.0%) or no job (86.7%). Most women answered that husbands made a decisio...
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

A descriptive study of gambling practices and problem gambling among internal migrants in Muse, Northern Shan, Myanmar.
In conclusion, this study showed that types of gambling, such as Nhit-Lone, cards and dice games and higher involvement and intensity were associated with problem gambling. The findings provide new and important insights into gambling behavior among internal migrant workers in the border area with China and highlight the need for culturally specific preventive measures for the Myanmar population, with preference to gambling types. PMID: 30962662 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Coffee consumption and liver cancer risk in Japan: a meta-analysis of six prospective cohort studies.
Authors: Tamura T, Hishida A, Wakai K Abstract Previous epidemiological studies have shown that coffee consumption may reduce liver cancer risk. The present study aimed to summarize the evidence for this association in the Japanese population by performing a meta-analysis of the results of relevant cohort studies conducted in Japan. We searched studies published prior to September 1, 2018 in PubMed. Extracted data were analyzed using a random effects model. A total of six cohort studies from five publications were included in the final analysis. The pooled estimate of relative risk with 95% confidence interval (CI)...
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

Spontaneous remission of giant cell arteritis: possible association with a preceding acute respiratory infection and seropositivity to Chlamydia pneumoniae antibodies.
Authors: Maekawa M, Iwadate T, Watanabe K, Yamamoto R, Imaizumi T, Yamakawa T Abstract Recent epidemiological or immunopathological studies demonstrate the possible association between giant cell arteritis and infectious agents including Chlamydia pneumoniae. A 62-year-old Japanese man with type 1 diabetes mellitus developed biopsy-proven giant cell arteritis after acute upper respiratory infection. Serological examination indicated concurrent re-infection with C. pneumoniae. Clinical manifestations of the vasculitis subsided within a month without any immunosuppressive therapy, and no relapse was observed for the ...
Source: Nagoya Journal of Medical Science - April 10, 2019 Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research