Safe Cardioversion for Patients with Acute-Onset Atrial Fibrillation and Flutter: Practical Concerns and Considerations
Publication date: Available online 13 June 2019Source: Canadian Journal of CardiologyAuthor(s): Ian G. Stiell, M. Sean McMurtry, Andrew McRae, Ratika Parkash, Frank Scheuermeyer, Clare L. Atzema, Allan SkanesAbstractThis commentary discusses concerns raised by Canadian emergency physicians regarding Recommendations 2 and 6 from the recent CCS 2018 Update for atrial fibrillation. These recommendations narrow the window for safe cardioversion and suggest four weeks of anticoagulation for all patients undergoing urgent cardioversion regardless of their CHADS-65 status. We discuss the implications of GRADE weak recommendations...
Source: Canadian Journal of Cardiology - June 14, 2019 Category: Cardiology Source Type: research

Sustaining Improvements in Cardiorespiratory Fitness and Muscular Strength in Cardiac Rehabilitation
Publication date: Available online 13 June 2019Source: Canadian Journal of CardiologyAuthor(s): Carl J. Lavie, Cemal Ozemek, Salvatore Carbone, Sergey Kachur (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - June 14, 2019 Category: Cardiology Source Type: research

The Lifelong Burden of Homozygous Familial Hypercholesterolemia
Publication date: Available online 13 June 2019Source: Canadian Journal of CardiologyAuthor(s): Ambuja Banerjee, Latifah Alothman, Patrick Couture, Jean Bergeron, Alexandre M. Bélanger, Isabelle Ruel, Jacques GenestAbstractHomozygous familial hypercholesterolemia (HoFH) is caused by mutations in the LDLR gene. It is diagnosed in children or youth presenting with extensive tendinous and cutaneous xanthomas and extreme elevation of LDL-cholesterol. Untreated, premature coronary artery disease develops in the teenage years or earlier and survival above 30 years of age is rare. Here we describe the clinical course of a ...
Source: Canadian Journal of Cardiology - June 14, 2019 Category: Cardiology Source Type: research

Periprocedural Anticoagulation for Cardioversion of Acute Onset Atrial Fibrillation and Flutter: Evidence Base for Current Guidelines
Publication date: Available online 12 June 2019Source: Canadian Journal of CardiologyAuthor(s): Jason G. Andrade, L. Brent MitchellABSTRACTThe practice of electrical or pharmacological cardioversion (CV) to restore sinus rhythm in patents with symptomatic atrial fibrillation (AF) or atrial flutter (AFL) has been a part of clinical practice for over 100 years. For almost as long as CV has been performed, it has been recognised that the act of restoring sinus rhythm is associated with an increased risk of stroke and systemic embolism, and that oral anticoagulation (OAC) therapy can be used to prevent peri-CV thromboembolism....
Source: Canadian Journal of Cardiology - June 13, 2019 Category: Cardiology Source Type: research

Right ventricular diastolic function and right atrial function and their relation with exercise capacity in Ebstein anomaly
Publication date: Available online 12 June 2019Source: Canadian Journal of CardiologyAuthor(s): Yohei Akazawa, Tao Fujioka, Andreas Kühn, Wei Hui, Cameron Slorach, Christoph Roehlig, Luc Mertens, Manfred Vogt, Mark K. FriedbergAbstractBackgroundRight ventricular (RV) diastolic function and right atrial (RA) function are poorly characterized in patients with Ebstein anomaly (EA) but may influence functional capacity. We aimed to evaluate RV diastolic function and RA function in EA and study their relationship with biventricular systolic function and exercise capacity.MethodsSeventy-two EA patients and 69 controls prosp...
Source: Canadian Journal of Cardiology - June 13, 2019 Category: Cardiology Source Type: research

Portal vein pulsatility after cardiac surgery – who cares?
Publication date: Available online 11 June 2019Source: Canadian Journal of CardiologyAuthor(s): Varinder K. Randhawa, Michael Zhen-Yu Tong, Edward G. Soltesz (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - June 11, 2019 Category: Cardiology Source Type: research

CD34+ Stem Cells: Promising Roles in Cardiac Repair and Regeneration
Publication date: Available online 11 June 2019Source: Canadian Journal of CardiologyAuthor(s): Tina Binesh Marvasti, Faisal J. Alibhai, Richard D. Weisel, Ren-Ke LiAbstractCell therapy has received significant attention as a novel therapeutic approach to restore cardiac function after injury. CD34+ stem cells have been investigated for their ability to promote angiogenesis and contribute to the prevention of remodeling post infarct. However, there are significant differences between murine and human CD34+ cells; understanding these differences may benefit the therapeutic use of these cells. Here we discuss the function of...
Source: Canadian Journal of Cardiology - June 11, 2019 Category: Cardiology Source Type: research

Antiplatelet Therapy and Coronary Artery Bypass Grafting: Analysis of current evidence with a focus on acute coronary syndrome
Publication date: Available online 11 June 2019Source: Canadian Journal of CardiologyAuthor(s): Saurabh Gupta, Emilie P. Belley-Cote, Parisa Agahi, Ameen Basha, Iqbal Jaffer, Shamir Mehta, J.-D. Schwalm, Richard P. WhitlockAbstractThis review was undertaken to summarize and discuss the current evidence around antiplatelet therapy and coronary artery bypass grafting (CABG). Aspirin (ASA) monotherapy remains the standard of care amongst patients before and after CABG. The role of more intense antiplatelet therapy, specifically P2Y12 inhibitors, in improving clinical outcomes and graft patency is becoming increasingly apparen...
Source: Canadian Journal of Cardiology - June 11, 2019 Category: Cardiology Source Type: research

Clinical Decision Support to Reduce Contrast-Induced Kidney Injury during Cardiac Catheterization: Design of a Randomized Stepped-Wedge Trial
ConclusionThe Contrast RISK study leverages information technology systems to identify patients’ risk, coupled with evidence-based protocols, audit and feedback to reduce CI-AKI in cardiac catheterization laboratories across Alberta. If effective, this intervention can be broadly scaled and sustained to improve the safety of cardiac catheterization.Trial registrationClinicalTrials.gov number: NCT03453996 (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - June 8, 2019 Category: Cardiology Source Type: research

Challenges in assessing the incidence of atrial fibrillation hospitalizations
Publication date: Available online 7 June 2019Source: Canadian Journal of CardiologyAuthor(s): Michelle Samuel, James M. Brophy (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - June 8, 2019 Category: Cardiology Source Type: research

When the Myocardium gets MIFfed: Macrophage Inhibitory Factor as a Biomarker in Acute Coronary Artery Disease
Publication date: Available online 8 June 2019Source: Canadian Journal of CardiologyAuthor(s): Saskia Haitjema, Imo E. Hoefer (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - June 8, 2019 Category: Cardiology Source Type: research

To Turn Over Rocks For TAVR: Correlation between closure time with adenosine diphosphate and the severity of paravalvular leak in the setting of an acute aortic valve-in-valve transcatheter procedure
We report a case of severe aortic stenosis with an extremely high calcium score who underwent a transfemoral transcatheter aortic valve replacement (TAVR) with an Evolut R and needed a valve-in-valve approach with a SAPIEN 3 to treat significant paravalvular leak (PVL). Interestingly, the closure time with adenosine diphosphate (CT-ADP), as assessed with the PFA-100 (Platelet Function Analyzer 100, Siemens Healthcare Diagnostics), measured after each important step of this complex procedure, correlated very well with the severity of the PVL. (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - June 1, 2019 Category: Cardiology Source Type: research

MTWA in ICD implantation decision making in primary prevention of sudden cardiac death in nonischemic cardiomyopathy - remarks after DANISH study
Publication date: Available online 30 May 2019Source: Canadian Journal of CardiologyAuthor(s): Danilowicz-Szymanowicz Ludmila, Molon Giulio (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Infusions of large synthetic HDL containing trimeric apoA-I stabilize atherosclerotic plaques in hypercholesterolemic rabbits
Publication date: Available online 30 May 2019Source: Canadian Journal of CardiologyAuthor(s): Cinzia Parolini, Maria Pia Adorni, Marco Busnelli, Stefano Manzini, Eleonora Cipollari, Elda Favari, Paolo Lorenzon, Giulia S. Ganzetti, Juergen Fingerle, Franco Bernini, Giulia ChiesaABSTRACTBackgroundAmong strategies to reduce the remaining risk of cardiovascular disease, interest has focused on using infusions of synthetic HDL (sHDL).MethodsNew Zealand rabbits underwent a perivascular injury at both carotids and were randomly allocated into two protocols: 1) a single dose study, where rabbits were treated with a single infusio...
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Sex differences in the long-term prognosis of dilated cardiomyopathy
Publication date: Available online 30 May 2019Source: Canadian Journal of CardiologyAuthor(s): Antonio Cannatà, Enrico Fabris, Marco Merlo, Jessica Artico, Piero Gentile, Carola Pio Loco, Andrea Ballaben, Federica Ramani, Giulia Barbati, Gianfranco SinagraAbstractBackgroundDilated Cardiomyopathy (DCM) represents a specific phenotype of heart failure (HF). Sex differences in the long-term prognosis of patients with DCM are unknown. Aim of this study is to investigate the long-term prognostic role of gender in a large cohort of DCM patients.Methods1113 DCM patients have been prospectively enrolled. To investigate the ...
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

External validation of the model of thrombo-embolic risk in hypertrophic cardiomyopathy patients
ConclusionsHCM Risk-CVA demonstrated a possibly helpful discrimination for TE when applied in a new set of HCM patients. However, the accurate estimation of absolute risk should be explored in future studies. (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

An unusual presentation of a cardiac thrombus
We describe the case of a patient with an evolving left atrial cardiac mass associated with pulmonary vein thrombosis. The patient presented no symptoms. Imaging follow-up revealed increase in size despite rivaroxaban therapy. Operative resection was performed and pathological examination was compatible with pulmonary vein thrombus. This case illustrates an unusual presentation of cardiac thrombus.SummaryWe describe the case of an asymptomatic patient with an evolving left atrial cardiac mass. On pathological examination, this mass was determined to be a pulmonary vein thrombus. This case demonstrates an unusual presentati...
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Editorial Board
Publication date: June 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 6Author(s): (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Table of Contents
Publication date: June 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 6Author(s): (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Information for Readers
Publication date: June 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 6Author(s): (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

President’s Page
Publication date: June 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 6Author(s): Dr Andrew Krahn (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Critical Care Cardiology: A Fellow’s Guide to Training Pathways
Publication date: June 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 6Author(s): Lior Bibas, Barry Burstein, Joshua Wenner, Erin Rayner-Hartley, Richard Vandegriend, Sean van Diepen (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Percutaneous Decannulation of Femoral Venoarterial ECMO Cannulas Using MANTA Vascular Closure Device
Publication date: June 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 6Author(s): José M. Montero-Cabezas, R.W. van der Meer, Frank van der Kley, Carlos V. Elzo Kraemer, Jorge E. López Matta, Martin J. Schalij, A. de WegerAbstractExtracorporeal membrane oxygenation (ECMO) has been increasingly used in the treatment of refractory cardiac arrest and postarrest cardiogenic shock. We propose a technique for percutaneous decannulation of femoral venoarterial ECMO cannulas by using the MANTA vascular closure device, designed to close large-bore arteriotomies. This technique significantly simplifies th...
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Monitoring Direct Oral Anticoagulants: Longing for the Days When We Were in Control?
Publication date: June 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 6Author(s): P. Timothy Pollak, L. Brent Mitchell (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Postpartum Cardiovascular Prevention: The Need for a National Health Systems-Based Strategy
Publication date: June 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 6Author(s): Natalie Dayan, Kara Nerenberg (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

High-Density Lipoprotein-Based Therapeutics: Can a Novel Mechanism Succeed Where Previous Approaches Have Failed?
Publication date: June 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 6Author(s): Liam R. Brunham (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Aortic Root Enlargement—Is It a Safe and Effective Approach to Prevent Patient-Prosthesis Mismatch and Is It for Everyone?
Publication date: June 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 6Author(s): Harold L. Lazar (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Association of Soluble ST2 Serum Levels With Outcomes in Pediatric Dilated Cardiomyopathy
This study aimed to assess the prognostic value of sST2 in PDCM.MethodsNinety-four patients with PDCM were enrolled after admission from 2 centres in China and followed up for adverse events (death, cardiac transplantation, and heart-failure–related rehospitalization). B-type natriuretic peptide (BNP) and sST2 levels were measured.ResultsOver a median of 678 (interquartile range [IQR]: 533-785) days, 28 (29.8%) adverse events occurred. Patients in the highest tertile of sST2 levels had increased risk of short-term (
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

The Effects of Acute Atmospheric Pressure Changes on the Occurrence of ST-Elevation Myocardial Infarction: A Case-Crossover Study
ConclusionsAcute air pressure decrease is associated with higher odds of a STEMI event 7 days after exposure. Weather advisories might be issued when atmospheric pressure decrease occurs.RésuméContexteRares sont les études qui ont exploré l'influence d'une exposition à court terme à des changements de pression atmosphérique sur la survenue soudaine d'un infarctus du myocarde avec élévation du segment ST (STEMI). Nous avons cherché à évaluer l'association entre des changements de pression atmosphérique aigus et la survenue du STEMI.M&...
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Erratum
Publication date: June 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 6Author(s): (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Infective Endarteritis and Mycotic Pseudoaneurysms in a Pediatric Patient With Aortic Coarctation
Publication date: June 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 6Author(s): Alanna M. Gilmour, Eva Welisch, Dirk E. Bock, Michael J. GrattanAbstractAn 11-year-old boy presented with Staphylococcus aureus infective endarteritis and mycotic pseudoaneurysms within the context of a previously undiagnosed aortic coarctation. He had an urgent resection of the pseudoaneurysm and coarctation repair. Nuances to his initial diagnosis and key learning points related to the complication of pseudoaneurysm are discussed.RésuméUn garçon de 11 ans a présenté une endartérite inf...
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

The Continuation of Trickle-Down Medicine: Soluble Suppression of Tumorigenicity-2 (sST2) in Pediatric Heart Failure
Publication date: June 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 6Author(s): Steven C. Greenway (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

“Ticagrelor or Prasugrel, Doctor?": The basis for decision in clinical practice
Publication date: Available online 28 May 2019Source: Canadian Journal of CardiologyAuthor(s): Guillaume Marquis-Gravel, Francesco Costa, Laurie-Anne Boivin-Proulx (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 29, 2019 Category: Cardiology Source Type: research

Chronic Kidney Disease and the Pathophysiology of Valvular Heart Disease
Publication date: Available online 28 May 2019Source: Canadian Journal of CardiologyAuthor(s): Julien Ternacle, Nancy Côté, Laura Krapf, Annabelle Nguyen, Marie-Annick Clavel, Philippe PibarotABSTRACTValvular heart calcification is common in patients with chronic kidney disease (CKD), especially in those receiving hemodialysis therapy, and it is associated with poor prognosis. Furthermore, progression of valvular heart disease (VHD) and structural valve deterioration of bioprosthetic valves are faster in these patients. Mechanisms involved in the pathophysiology of VHD are similar between patients with and wit...
Source: Canadian Journal of Cardiology - May 29, 2019 Category: Cardiology Source Type: research

Inexpensive, High Fidelity Model to Simulate Ultrasound-Guided Pericardiocentesis For Cardiology Resident Training
This study proves that a low-cost, high-fidelity model can be constructed and easily implemented into the formal curriculum of Adult Cardiology Residency Programs. It allows residents the opportunity to practice pericardiocentesis in a low-risk setting on a high yield device. (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 29, 2019 Category: Cardiology Source Type: research

Risk of Hospital Admissions in Patients with Atrial Fibrillation: A Systematic Review and Meta-analysis
ConclusionsPatients with AF have a very high risk of being admitted to the hospital, both for cardiovascular and non-cardiovascular causes. The development and implementation of preventive strategies should be a public health priority. (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 26, 2019 Category: Cardiology Source Type: research

Left Atrial Function and Sudden Cardiac Death
Publication date: Available online 24 May 2019Source: Canadian Journal of CardiologyAuthor(s): David Lee, Ratika Parkash (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 26, 2019 Category: Cardiology Source Type: research

Determinants and prevention of coronary disease in patients with chronic kidney disease
Publication date: Available online 25 May 2019Source: Canadian Journal of CardiologyAuthor(s): Rebecca Rodin, Christopher T. ChanAbstractChronic kidney disease (CKD) is associated with premature cardiovascular morbidity and mortality. Traditional Framingham risk factors contribute partially to the malignant form of cardiovascular disease (CVD) in CKD. Uremic specific risk factors including: chronic inflammation, retention of uremic toxins and abnormal bone mineral metabolism have independently been linked to the pathogenesis of premature vascular aging, atherosclerosis, and CVD. This review will explore the mechanisms by w...
Source: Canadian Journal of Cardiology - May 26, 2019 Category: Cardiology Source Type: research

The influence of sex differences on cardiopulmonary exercise metrics following heart transplant
Publication date: Available online 25 May 2019Source: Canadian Journal of CardiologyAuthor(s): Katelyn E. Uithoven, Joshua R. Smith, Jose R. Medina-Inojosa, Ray W. Squires, Erik H. Van Iterson, Thomas P. OlsonABSTRACTBackgroundPrevious work has shown sex-related differences in cardiopulmonary responses in heart failure (HF) patients; however, sex differences following heart transplant (HTx) have not been examined. Thus, we hypothesized women would demonstrate lower peak oxygen uptake (VO2peak), but similar ventilatory efficiency (VE/VCO2 slope) compared to men prior to HTx. Furthermore, we hypothesized that following HTx, ...
Source: Canadian Journal of Cardiology - May 26, 2019 Category: Cardiology Source Type: research

The current role of viability imaging to guide revascularization and therapy decisions in patients with heart failure and reduced LV function
Publication date: Available online 24 May 2019Source: Canadian Journal of CardiologyAuthor(s): Riina M. Kandolin, Christiane C. Wiefels, Cláudio Tinoco Mesquita, Aun-Yeong Chong, Paul Boland, David Glineur, Louise Sun, Rob S. Beanlands, Lisa M. MielniczukAbstractThis review describes the current evidence and controversies for viability imaging to direct revascularization decisions and the impact on patient outcomes. Balancing procedural risks and possible benefit from revascularization is a key question in patients with heart failure of ischemic origin (IHF). Different stages of ischemia induce adaptive changes in m...
Source: Canadian Journal of Cardiology - May 24, 2019 Category: Cardiology Source Type: research

Training/Practice: Health Policy and Promotion The risk of cardiovascular events on cannabis’ highest day
In this study, population-based administrative databases in Ontario, Canada were used to evaluate the association between “4/20” and cardiovascular events. An increased risk of cardiovascular events on a population-level was not observed on “4/20”. Additional research into the changes in prevalence of use of cannabis with recreational legalization and acute and chronic risk with cannabis use is suggested. (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 23, 2019 Category: Cardiology Source Type: research

Low Density Lipoprotein Receptor Related Protein 6-mediated Cardiovascular Diseases and associated signaling pathways
Publication date: Available online 23 May 2019Source: Canadian Journal of CardiologyAuthor(s): Sheng Kang, Jie-Lin PuAbstractLow density lipoprotein receptor related protein 6 (LRP6) is a member of the low density lipoprotein receptors (LDLRs) family and accumulating evidence point to the critical role of LRP6 in cardiovascular health and homeostasis. In addition to present the well-appreciated roles in canonical signaling regulating blood pressure, blood glucose and lipid metabolism, and involved in atherosclerosis, cardiac valve disease, cardiac development, Alzheimer disease and tumorigenesis, LRP6 also inhibits non-can...
Source: Canadian Journal of Cardiology - May 23, 2019 Category: Cardiology Source Type: research

Surgical turndown: “what’s in a name?” For patients deemed ineligible for surgical revascularization
Publication date: Available online 20 May 2019Source: Canadian Journal of CardiologyAuthor(s): Hung Q. Ly, Mohamed Nosair, Raymond CartierABSTRACTOptimal revascularization in severe ischemic heart disease (SIHD) is addressed in all clinical guidelines. With an aging patient population, a growing challenge remains the management of SIHD patients deemed ineligible for surgical revascularization, the so-called surgical turndown patient. The status of surgical ineligibility remains associated with worse clinical outcomes. As the general population grows older and comorbidities increase, this subset of SIHD will likely increase...
Source: Canadian Journal of Cardiology - May 21, 2019 Category: Cardiology Source Type: research

U.S. National Trends in the Management and Outcomes of Constrictive Pericarditis: 2005-2014
Publication date: Available online 20 May 2019Source: Canadian Journal of CardiologyAuthor(s): Makoto Mori, Clancy Mullan, Syed Usman Bin Mahmood, Sameh Yousef, Keith J. Pelletier, Abeel A. Mangi, Arnar GeirssonAbstractBackgroundPatient characteristics, trends in the management strategy, and outcomes of patients with constrictive pericarditis have not been characterized at the national scale.MethodsAnnual trends of patients admitted to hospitals in the U.S. with constrictive pericarditis was evaluated using the National Inpatient Sample (NIS) dataset between 2005-2014. Poisson regression models adjusting for the U.S. censu...
Source: Canadian Journal of Cardiology - May 21, 2019 Category: Cardiology Source Type: research

Making the Cut: Perspectives on the Surgical Management of Infective Endocarditis among People Who Use Intravenous Drugs
We describe some of the perspectives in the literature around second valve replacement for PUID with IE, arguing that moralistic arguments are not based on evidence and perpetuate the stigma experienced by PUID seeking treatment for IE. Finally, we explore the role of substance use interventions in the treatment of PUID with IE, and advocate for further evidence. PUID with IE are a highly stigmatized patient subgroup for whom best practice management strategies are not always implemented, emphasizing the need for further research and advocacy. (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 21, 2019 Category: Cardiology Source Type: research

Circulating MIF levels predict clinical outcomes in patients with ST-elevation myocardial infarction following PCI
This study recruited 498 STEMI patients post percutaneous coronary intervention (PCI), 40 with stable angina pectoris (SAP) and 137 healthy participants. Plasma MIF levels were measured at admission and after PCI. The primary endpoints were in-hospital mortality and major adverse cardio- and/or cerebro-vascular events (MACE/MACCE) during hospitalization and 3.2-year follow-up period.ResultsAdmission MIF levels were elevated in 88.4% STEMI patients over the upper reference limit of healthy controls and it was 3-7 folds higher than that in SAP and control groups (122±61 vs. 39±19 vs. 17±8 ng/mL, P
Source: Canadian Journal of Cardiology - May 21, 2019 Category: Cardiology Source Type: research

Long-term enrollment in cardiac rehabilitation benefits cardiorespiratory fitness and skeletal muscle strength in men with cardiovascular disease
Publication date: Available online 21 May 2019Source: Canadian Journal of CardiologyAuthor(s): Mike Pryzbek, Maureen MacDonald, Paul Stratford, Angelica McQuarrie, Julie Richardson, Robert McKelvie, Ada TangAbstractBackgroundDespite known associations between fitness and recurrent cardiovascular events, changes in cardiorespiratory fitness (CRF) and muscle strength with long-term cardiac rehabilitation (CR) have not been extensively examined. The purpose of this study was to: 1) Examine changes in CRF and muscle strength associated with long-term CR program enrollment in men, and 2) Compare these changes to previously publ...
Source: Canadian Journal of Cardiology - May 21, 2019 Category: Cardiology Source Type: research

Reducing the burden of atrial fibrillation cost: is integrated care the answer?
Publication date: Available online 21 May 2019Source: Canadian Journal of CardiologyAuthor(s): Celine Gallagher, Jeroen Hendriks, Melissa E. Middeldorp, Adrian D. Elliott, Dennis H. Lau, Prashanthan Sanders (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 21, 2019 Category: Cardiology Source Type: research

The challenge of myocardial infarction in patients with mental illness
Publication date: Available online 15 May 2019Source: Canadian Journal of CardiologyAuthor(s): Gurleen Kaur, Joshua Schulman-Marcus (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - May 17, 2019 Category: Cardiology Source Type: research

Molecular autopsy implicates primary carnitine deficiency in sudden unexplained death and reversible short QT syndrome
We report a case of sudden unexplained death in a young asymptomatic woman in whom post-mortem genetic testing after a negative autopsy identified a homozygous pathogenic mutation in SLC22A5, which leads clinically to primary carnitine deficiency (PCD). Her brother was subsequently diagnosed clinically with short QT syndrome, received an implantable defibrillator, and was then found to carry the same pathogenic homozygous mutation, and critically low levels of carnitine. His QT improved with carnitine supplementation, highlighting the close relationship between electrophysiology and biochemistry, and the importance of post...
Source: Canadian Journal of Cardiology - May 17, 2019 Category: Cardiology Source Type: research