Suppression of Sertoli cell tumour development during the first wave of spermatogenesis in inhibin ?-deficient mice.

In conclusion, acute FSH suppression during the 1st or 2nd week after birth in Inha-KO mice profoundly suppresses Sertoli cell tumour progression, probably by inhibiting proliferation in the adult, with early postnatal Sertoli cells being most sensitive to FSH action.
PMID: 26488911 [PubMed - as supplied by publisher]

Source: Reproduction, Fertility, and Development - October 22, 2015 Category: Reproduction Medicine Authors: Haverfield JT, Stanton PG, Loveland KL, Zahid H, Nicholls PK, Olcorn JS, Makanji Y, Itman CM, Simpson ER, Meachem SJ Tags: Reprod Fertil Dev Source Type: research