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Total 1776 results found since Jan 2013.
Iptakalim improves cerebral microcirculation in mice after ischemic stroke by inhibiting pericyte contraction
In this study we investigated the impacts of iptakalim on pericytes contraction in stroke. Mice were subjected to cerebral artery occlusion (MCAO), then administered iptakalim (10 mg/kg, ip). We showed that iptakalim administration significantly promoted recovery of cerebral blood flow after cerebral ischemia and reperfusion. Furthermore, we found that iptakalim significantly inhibited pericytes contraction, decreased the number of obstructed capillaries, and improved cerebral microcirculation. Using a collagen gel contraction assay, we demonstrated that cultured pericytes subjected to oxygen-glucose deprivation (OGD) cons...
Source: Acta Pharmacologica Sinica - October 26, 2021 Category: Drugs & Pharmacology Authors: Ruo-Bing Guo Yin-Feng Dong Zhi Yin Zhen-Yu Cai Jin Yang Juan Ji Yu-Qin Sun Xin-Xin Huang Teng-Fei Xue Hong Cheng Xi-Qiao Zhou Xiu-Lan Sun Source Type: research
Exosomal microRNAs as Potential Biomarkers and Therapeutic Agents for Acute Ischemic Stroke: New Expectations
The morbidity and mortality rates of ischemic stroke (IS) are very high, and IS constitutes one of the main causes of disability and death worldwide. The pathogenesis of ischemic stroke includes excitotoxicity, calcium overload, oxygen radical injury, inflammatory reactions, necrosis/apoptosis, destruction of the blood-brain barrier (BBB), and other pathologic processes. Recent studies have shown that exosomes are critical to the pathogenesis, diagnosis, and treatment of cerebral infarctions resulting from ischemic stroke; and there is growing interest in the role of exosomes and exosomal miRNAs in the diagnosis and treatm...
Source: Frontiers in Neurology - January 24, 2022 Category: Neurology Source Type: research
Integrating serum proteomics and metabolomics to compare the common and distinct features between acute aggressive ischemic stroke (APIS) and acute non-aggressive ischemic stroke (ANPIS)
In this study, we integrated serum proteomics and metabolomics to explore the similarities and differences in pathophysiological processes between APIS and ANPIS. The global metabolic networks have been constructed, and the crucial common pathophysiological processes and the key distinct pathophysiological features between APIS and ANPIS were investigated based on the differentially expressed proteins and metabolites (DEPs/DEMs). Furthermore, pivotal serum proteins (SAA1 and S100A9) were detected in a dependent set to validate the key pathophysiological characteristics, as well as to assess the possibility of them being us...
Source: Journal of Proteomics - April 14, 2022 Category: Biochemistry Authors: Minchao Lai Xiaojun Zhang Danya Zhou Xiaojuan Zhang Mengting Zhu Qingxian Liu Ye Zhang Dian Wang Source Type: research
The association of admission ionized calcium with outcomes of thrombolysed patients with anterior circulation ischemic stroke
ConclusionThe current results found that ionized calcium might be associated with early neurological improvement, but had no association with 3 months' outcome in anterior circulation AIS patients after IVT.
Source: Brain and Behavior - December 7, 2022 Category: Neurology Authors: Yan ‐Li Qi,
Qiong Wu,
Xiao‐Qiu Li,
Zhong‐He Zhou,
Cheng Xia,
Xin‐Hong Wang,
Hui‐Sheng Chen Tags: ORIGINAL ARTICLE Source Type: research
Mitral annular calcification as a predictor of stroke in the multiethnic study of atherosclerosis
CONCLUSION: MAC is an independent predictor of long-term stroke risk in a racially diverse population beyond conventional cardiovascular risk factors and atrial fibrillation.PMID:37409651 | DOI:10.2459/JCM.0000000000001524
Source: Atherosclerosis - July 6, 2023 Category: Cardiology Authors: Afiachukwu Onuegbu Francesca Calicchio April Kinninger Rine Nakanishi John J Carr Khurram Nasir Rebecca Gottesman Matthew Budoff Source Type: research
Ivabradine is BEAUTIFUL in concurrent acute coronary syndrome and stroke
We report the safe use of oral ivabradine in 2 patients with concurrent ACS and stroke, achieving heart rate reduction and angina relief without affecting blood pressure.
Source: International Journal of Cardiology - September 20, 2012 Category: Cardiology Authors: Pow-Li Chia, David Foo Tags: Online letters to the Editor Source Type: research
MiRNA-424 Protects Against Permanent Focal Cerebral Ischemia Injury in Mice Involving Suppressing Microglia Activation Basic Sciences
Conclusions—
MiR-424 overexpression lessened the ischemic brain injury through suppressing microglia activation by translational depression of key activators of G1/S transition, suggesting a novel miR-based intervention strategy for stroke.
Source: Stroke - May 24, 2013 Category: Neurology Authors: Zhao, H., Wang, J., Gao, L., Wang, R., Liu, X., Gao, Z., Tao, Z., Xu, C., Song, J., Ji, X., Luo, Y. Tags: Acute Cerebral Infarction Basic Sciences Source Type: research
Excitotoxicity and stroke: Identifying novel targets for neuroprotection
Publication date: April 2014 Source:Progress in Neurobiology, Volume 115 Author(s): Ted Weita Lai , Shu Zhang , Yu Tian Wang Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing link between ischemia and neuronal death, and intervening the mechanistic steps that lead to excitotoxicity can prevent stroke damage. Interest in excitotoxicity began fifty years ago when monosodium glutamate was found to be neurotoxic. Evidence soon demonstrated that glutamate is not only the primary excitatory neurotransmitter in the adult brain, but also a critical transmitter for signaling neurons to d...
Source: Progress in Neurobiology - November 6, 2014 Category: Neuroscience Source Type: research
Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke
Conclusion:
Our study is the first to show enhanced exogenous repopulation of a neuronal phenotype after stroke using techniques aimed at GABAergic cell induction prior to delivery that resulted in accelerated and improved functional recovery.
Source: Stem Cell Research and Therapy - September 29, 2015 Category: Stem Cells Authors: Hima AbeysingheLaita BokhariAnita QuigleyMahesh ChoolaniJerry ChanGregory DustingJeremy CrookNao KobayashiCarli Roulston Source Type: research
Potential Utility of Multidetector Computed Tomography to Identify both Cardiac Embolic Sources and Coronary Artery Disease in Patients with Embolic Stroke
Conclusions: Our results suggest that MDCT has potential to identify both cardiac embolic sources and CAD in patients with embolic stroke but without known CAD.Cardiology 2016;133:205-210
Source: Cardiology - November 30, 2015 Category: Cardiology Source Type: research
S100β as a biomarker for differential diagnosis of intracerebral hemorrhage and ischemic stroke.
CONCLUSION: S100β could serve as a potential biomarker for differentiating between ICH and IS and predicting short-term functional outcome after ICH.
PMID: 27078704 [PubMed - as supplied by publisher]
Source: Neurological Research - April 16, 2016 Category: Neurology Tags: Neurol Res Source Type: research
Distinguishing features of microglia- and monocyte-derived macrophages after stroke
AbstractAfter stroke, macrophages in the ischemic brain may be derived from either resident microglia or infiltrating monocytes. Using bone marrow (BM)-chimerism and dual-reporter transgenic fate mapping, we here set out to delimit the responses of either cell type to mild brain ischemia in a mouse model of 30 min transient middle cerebral artery occlusion (MCAo). A discriminatory analysis of gene expression at 7 days post-event yielded 472 transcripts predominantly or exclusively expressed in blood-derived macrophages as well as 970 transcripts for microglia. The differentially regulated genes were fu rther collated wi...
Source: Acta Neuropathologica - December 16, 2017 Category: Neurology Source Type: research
Neuroimmunological interactions in stroke
ConclusionsUnderstanding the relationship between the immune system and the nervous system not only deepens our knowledge of stroke but also provides new diagnostic, prognostic, and therapeutic strategies that may increase the quality of life of stroke patients.ResumenIntroducciónEl ictus es una de las principales causas de mortalidad en el mundo y debido al incremento en la expectativa de vida su incidencia va en aumento; sin embargo, el desarrollo de nuevos medicamentos con utilidad clínica ha sido prácticamente nulo, por lo que hasta la fecha el tratamiento de estos pacientes es muy limitado.DesarrolloLa evidencia b...
Source: Neurologia - October 5, 2018 Category: Neurology Source Type: research
