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Total 1776 results found since Jan 2013.

Genetic deletion of calcium/calmodulin-dependent protein kinase kinase ß (CaMKK ß) or CaMK IV exacerbates stroke outcomes in ovariectomized (OVXed) female mice
Conclusions: Inhibition of CaMKK signaling exacerbated stroke outcome and increased BBB impairment, transcriptional inactivation and inflammatory responses in females after stroke. Therefore, CaMKK signaling may be a potential target for stroke treatment in both males and females.
Source: BMC Neuroscience - October 21, 2014 Category: Neuroscience Authors: Lin LiuLouise McCulloughJun Li Source Type: research

Podcast: Cerebrolysin for acute ischaemic stroke
When someone has an acute ischemic stroke, urgent and reliable treatments will reduce their risks of disability or dying from their brain tissue damage. The treatments used vary around the world, and a drug called cerebrolysin is widely used in post-Soviet countries, Eastern Europe, Central and Southeast Asia. In April 2017, the latest update of this review was published by researchers from Kazan Federal University in Russia and Chinara Razzakova, a PhD student from the university interviewed one of the authors, Liliya Eugenevna, for this podcast." This Cochrane Review is about a medicine called cerebrolysin, which is used...
Source: Cochrane News and Events - January 10, 2019 Category: Information Technology Authors: Lydia Parsonson Source Type: news

Serum lipoprotein(a) and risk of hemorrhagic stroke among incident peritoneal dialysis patients: a large study from a single center in China.
Conclusions: Among patients with incident PD, a higher serum Lp(a) level may predict a lower risk of hemorrhagic stroke. PMID: 31498021 [PubMed - in process]
Source: Renal Failure - September 10, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The back and forth of axonal injury and repair after stroke
Purpose of review: The axon plays a central role in both the injury and repair phases after stroke. This review highlights emerging principles in the study of axonal injury in stroke and the role of the axon in neural repair after stroke. Recent findings: Ischemic stroke produces a rapid and significant loss of axons in the acute phase. This early loss of axons results from a primary ischemic injury that triggers a wave of calcium signaling, activating proteolytic mechanisms and downstream signaling cascades. A second progressive phase of axonal injury occurs during the subacute period and damages axons that survive the in...
Source: Current Opinion in Neurology - November 7, 2014 Category: Neurology Tags: TRAUMA AND REHABILITATION: Edited by S. Thomas Carmichael Source Type: research

Calcium/Calmodulin‐Dependent Protein Kinase Kinase β (CaMKK β) is Neuroprotective in Stroke in Aged Mice
This article is protected by copyright. All rights reserved.
Source: European Journal of Neuroscience - June 15, 2016 Category: Neuroscience Authors: Lin Liu, Hui Yuan, Kyle Denton, Xue‐jun Li, Louise McCullough, Jun Li Tags: Research Report Source Type: research

Calcium/Calmodulin ‐Dependent Protein Kinase Kinase β (CaMKK β) is Neuroprotective in Stroke in Aged Mice
This article is protected by copyright. All rights reserved.
Source: European Journal of Neuroscience - June 15, 2016 Category: Neuroscience Authors: Lin Liu, Hui Yuan, Kyle Denton, Xue ‐jun Li, Louise McCullough, Jun Li Tags: Research Report Source Type: research

Neuroimaging and Blood Biomarkers in Functional Prognosis after Stroke.
CONCLUSION: Although some biomarkers and neuroimaging techniques have potential predictive value, none of the studies were able to support its use, alone or in association, as a clinically useful functionality predictor model. All the evaluated markers were considered insufficient to predict functional prognosis at three months, when applied in the first hours after stroke. Additional studies are necessary to identify reliable predictive markers for functional prognosis after ischemic stroke. PMID: 28229841 [PubMed - in process]
Source: Acta Medica Portuguesa - February 25, 2017 Category: Journals (General) Tags: Acta Med Port Source Type: research

The Metal and Metalloprotein Profile of Human Plasma as Biomarkers for Stroke Diagnosis
Publication date: Available online 7 April 2017 Source:Journal of Trace Elements in Medicine and Biology Author(s): Keaton S. Nahan, Kyle B. Walsh, Opeolu Adeoye, Julio A. Landero-Figueroa Stroke, a major cause of disability and mortality, affects someone in the United States every 40seconds. Stroke biomarkers, including those that could be used as a blood test for diagnosis of stroke, have been particularly elusive. We performed a double blind study to identify human plasma biomarkers for the diagnosis of stroke, including acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH). We utilized a three-track approach ...
Source: Journal of Trace Elements in Medicine and Biology - April 10, 2017 Category: Biochemistry Source Type: research

Calcium antagonists for acute ischemic stroke.
CONCLUSIONS: We found no evidence to support the use of calcium antagonists in people with acute ischemic stroke. PMID: 30758052 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 13, 2019 Category: General Medicine Authors: Zhang J, Liu J, Li D, Zhang C, Liu M Tags: Cochrane Database Syst Rev Source Type: research

Drug treatment strategies for osteoporosis in stroke patients.
Authors: Hsieh CY, Sung SF, Huang HK Abstract Introduction: Osteoporosis and subsequent fractures are well-recognized complications of stroke. However, drug treatment strategies for osteoporosis after stroke have been rarely discussed in the current guidelines for the management of stroke or osteoporosis.Areas covered: The authors review the epidemiology, characteristics, pathophysiology, and risk prediction of post-stroke osteoporosis and fractures. Then they provide an overview of existing evidence regarding drug treatment strategies for osteoporosis in stroke patients. They also review the effects on bone minera...
Source: Expert Opinion on Pharmacotherapy - March 11, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Thoracic Aortic < sup > 18 < /sup > F-Sodium Fluoride Activity and Ischemic Stroke in Patients With Established Cardiovascular Disease
CONCLUSIONS: In patients with established cardiovascular disease, thoracic aortic 18F-sodium fluoride activity is associated with the progression of atherosclerosis and future ischemic stroke. Arterial 18F-sodium fluoride activity identifies localized areas of atherosclerotic disease activity that are directly linked to disease progression and downstream regional clinical atherothrombotic events. (DIAMOND - Dual Antiplatelet Therapy to Reduce Myocardial Injury [DIAMOND], NCT02110303; Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis [SALTIRE II], NCT02132026; ...
Source: Atherosclerosis - February 20, 2022 Category: Cardiology Authors: Alexander J Fletcher Yong Y Tew Evangelos Tzolos Shruti S Joshi Jakub Kaczynski Jennifer Nash Samuel Debono Maria Lembo Jacek Kwiecinski Rong Bing Maaz B J Syed Mhairi K Doris Edwin J R van Beek Alistair J Moss William S Jenkins Niki L Walker Nikhil V Jos Source Type: research

Dietary calcium intake and risk of stroke: a dose-response meta-analysis.
CONCLUSION: These findings suggest that dietary calcium intake may be inversely associated with stroke in populations with low to moderate calcium intakes and in Asian populations. PMID: 23553167 [PubMed - in process]
Source: The American Journal of Clinical Nutrition - May 1, 2013 Category: Nutrition Authors: Larsson SC, Orsini N, Wolk A Tags: Am J Clin Nutr Source Type: research

Metabolomic analysis reveals novel small molecule plasma markers of hyperacute ischemic stroke (S30.001)
Conclusions: Utilizing targeted metabolomics, we found increased Glu and PLA and decreased citrate level in AIS patients within 6 hours of stroke onset. Glu, an excitatory neurotransmitter, and PLA, a known apoptotic marker, are both found in CSF and peri-infarct zone of ischemic stroke. Citrate is not only important in energy metabolism (anaerobic glycolysis), but also binds blood calcium to prevent clot formation. Building on previous studies, this study is a first step to help understand early metabolic landscape of AIS and highlights the role of potential CSF contribution to peripheral metabolic contents. However, furt...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Deng, W., Beecher, C., Burant, C., De Jong, F., Lopez, M., Wickham, T., Elia, M., Feeney, K., McMullin, D., Buonanno, F., Lo, E., Ning, M. Tags: Cerebrovascular Disease and Interventional Neurology: Diagnostics, Biomarkers, and Genetics Platform Blitz Source Type: research

Get Rid of Toxins to Reduce Risk of Stroke
Effects of Toxins I’ve been warning you about the toxins in our environment for years. They cause inflammation… They make you gain weight… They cause you to feel fatigued… Our exposure to them starts before we’re even born. One study found 287 chemicals and toxins in the blood of newborn babies.1 It’s shocking. What is in the air we breathe? We breathe in toxins and air pollutants every day. Carbon dioxide, lead, nitrogen oxide, sulfur dioxide, and particulate matter (PM). Causes of Stroke Now, a new study reveals that air pollution is responsible for as many as one-third of all strokes.2 That’...
Source: Al Sears, MD Natural Remedies - July 15, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Health Source Type: news

FDG PET Imaging as A Non-invasive Method to Demonstrate Peri-infarct Depression after Stroke
Conclusion: FDG PET imaging is reliable to reflect metabolic stress imposed by peri-infarct depression. Peri-infarct depression leads to the metabolic change in neurons, including suppression of mitochondria function and overactivation of glycolysis, thus deteriorate functional and tissue consequence. The insults from PID could be alleviated by improving mitochondria function.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Yao, J., Zhou, R., Shi, J., Zhang, H. Tags: Basic Science III Source Type: research