The effects of iron and zinc status on prognosis in pediatric Wilson’s disease
Publication date: Available online 24 May 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Şükrü Güngör, Mukadder Ayşe Selimoğlu, Fatma İlknur Varol, Serdal Güngör, Muhammed Mehdi ÜremişAbstractObjectivesWilson’s disease (WD) is a metabolic disorder leading to hepatic and extrahepatic copper deposition. Several studies have reported that besides copper (Cu), iron (Fe) and zinc (Zn) are also accumulated at varying levels in various tissues in WD. However, there is not an adequate number of studies investigating the effects of Fe and Zn status on WD present...
Source: Journal of Trace Elements in Medicine and Biology - May 25, 2019 Category: Biochemistry Source Type: research

Lead poisoning due to ingestion of lead-contaminated opium: A diagnostic study on patients’ imaging findings
Publication date: September 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 55Author(s): Nasim Zamani, Hossein Hassanian-Moghaddam, Hooman Bahrami-Motlagh, Sara Ahmadi, Scott PhillipsAbstractObjectivesOur study attempts to determine if for patients following ingestion of lead-contaminated opium, radiographs [plain X-ray (KUB)] or unenhanced computed tomography (CT scan) of the abdomen may be predictive of lead poisoning.MethodsOur study is concerned with patients of>21 years with elevated lead concentrations, who had undergone KUB or CT. Patients with other toxicities who had undergone similar imag...
Source: Journal of Trace Elements in Medicine and Biology - May 25, 2019 Category: Biochemistry Source Type: research

Strontium stimulates alkaline phosphatase and bone morphogenetic protein-4 expression in rat chondrocytes cultured in vitro
Publication date: Available online 19 May 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Jinfeng Zhang, Xiaoyan Zhu, Yezi Kong, Yan Huang, Xukun Dang, Linshan Mei, Baoyu Zhao, Qing Lin, Jianguo WangAbstractThe trace element strontium has a significant impact on cartilage metabolism. However, the direct effects of strontium on alkaline phosphatase (ALP), a marker of bone growth, and bone morphogenetic protein-4 (BMP-4), which plays a key role in the regulation of bone and cartilage development, are not entirely clear. In order to understand the mechanisms involved in these processes, the chondrocyte...
Source: Journal of Trace Elements in Medicine and Biology - May 21, 2019 Category: Biochemistry Source Type: research

Complementary techniques (spICP-MS, TEM, and HPLC-ICP-MS) reveal the degradation of 40 nm citrate-stabilized Au nanoparticles in rat liver after intraperitoneal injection
ConclusionsThis study underlines that degradation of gold nanoparticles to low-molecular gold species might have to be taken into account in future for studies on their toxicological behaviour and their potential use in clinical applications.Graphical abstract (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - May 19, 2019 Category: Biochemistry Source Type: research

Editorial Board
Publication date: July 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 54Author(s): (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - May 18, 2019 Category: Biochemistry Source Type: research

Effects of zinc supplementation on serum adiponectin concentration and glycemic control in patients with type 2 diabetes
Publication date: Available online 14 May 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Somayyeh Asghari, Mohammad Javad Hosseinzadeh-Attar, Elham Alipoor, Mojtaba Sehat, Mohammad Reza Mohajeri-TehraniAbstractBackgroundPrevious studies have suggested that zinc is involved in insulin homeostasis. Adiponectin is a well-known adipokine with anti-diabetic, anti-atherogenic, and anti-inflammatory properties. The aim of this study was to investigate the effect of zinc supplementation on glycemic control, and the potential mediating role of adiponectin, in patients with type 2 diabetes.MethodsIn this ran...
Source: Journal of Trace Elements in Medicine and Biology - May 15, 2019 Category: Biochemistry Source Type: research

Dietary boron supplementation enhances sperm quality and immunity through influencing the associated biochemical parameters and modulating the genes expression at testicular tissue
Publication date: Available online 10 May 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Binsila B. Krishnan, Sellappan Selvaraju, Nisarani Kollurappa Shivakumar Gowda, Karthik Bhat Subramanya, Dintaran Pal, Santhanahalli Siddalingappa Archana, Raghavendra BhattaAbstractINTRODUCTION: Dietary boron improves immune and antioxidant status and calcium metabolism in mammals. However, till date the effects of dietary boron supplementation on male reproduction, especially on sperm production and sperm quality in farm animals are not documented.OBJECTIVE: The present study was aimed to investigate the infl...
Source: Journal of Trace Elements in Medicine and Biology - May 12, 2019 Category: Biochemistry Source Type: research

Complementary techniques (spICP-MS, TEM, and HPLC-ICP-MS) reveal the degradation of 40 nm citrate-stabilized Au nanoparticles in rat liver after intraperitoneal injection
ConclusionsThis study underlines that degradation of gold nanoparticles to low-molecular gold species might have to be taken into account in future for studies on their toxicological behaviour and their potential use in clinical applications.Graphical abstract (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - May 12, 2019 Category: Biochemistry Source Type: research

Heavy metal toxicity: an update of chelating therapeutic strategies
ConclusionHeavy metal poisoning is a common health problem because of mining, smelting, industrial, agricultural and sewage waste. Heavy metals can be efficiently excreted from the body following treatment with proper chelation agents.Graphical Abstract (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - May 12, 2019 Category: Biochemistry Source Type: research

Trace mineral composition of human breast milk from Brazilian mothers
Publication date: Available online 6 May 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Rafaella Regina Alves Peixoto, Carla Regina Bianchi Codo, Vitor Lacerda Sanches, Tamara Cristina Guiraldelo, Fábio Ferreira da Silva, Rafael Luis Ribessi, Sérgio Tadeu Martins Marba, Solange CadoreABSTRACTBackgroundHuman milk is a dynamic food and some important differences in composition can be found between the milk from preterm and terms infants. Additionally, in some situations, the mother’s own milk is unavailable and the use of milk from human milk banks is considered as the most approp...
Source: Journal of Trace Elements in Medicine and Biology - May 7, 2019 Category: Biochemistry Source Type: research

Alterations in membrane fluidity are involved in inhibition of GM-CSF-induced signaling in myeloid cells by zinc
In conclusion, we hypothesize that the incubation with zinc causes an alteration of membrane fluidity that hinders efficient receptor assembly as well as phosphorylation of signal molecules and therefore signal transduction. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - May 4, 2019 Category: Biochemistry Source Type: research

Metal(loid)s urinary level among workers of gas refinery and petrochemical companies: Health risk assessment of metal(loid)s in drinking water and dust
ConclusionOur results revealed the effect of gas refinery and petrochemical activities on increasing the metal(loid)s concentration of the worker's body and the necessity to protect this group. Additionally, the metal(loid)s intake from drinking water and inhaled dust posed no cancer risk to the workers. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - May 4, 2019 Category: Biochemistry Source Type: research

Boron-rich diet may regulate blood lipid profile and prevent obesity: A non-drug and self-controlled clinical trial
ConclusionIncreasing the intake of boron through dietary means might contribute to beneficial effects on lipid metabolism, obesity, and thyroid metabolism; salivary boron may reflect serum boron; and boron may be used as a cariostatic agent in dentistry. An increased intake of other dietary factors such as fiber, potassium, iron, vitamin A, and vitamin E in the boron-rich foods might have been responsible of the effects described. To our knowledge, this study is the first clinical study in which dietary boron intake is increased via foods. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - May 2, 2019 Category: Biochemistry Source Type: research

Long surviving classical Menkes disease treated with weekly intravenous copper therapy
We report here the case of a 29-year-old male with MD who tolerated long-term intravenous copper therapy initiated at 2 months. Molecular analysis revealed hemizygous deletion mutation of ATP7A previously reported in classical MD. Although neurodevelopement is poor, no major event of central nervous system is observed, and he enjoys a good social life by interacting using gestures. Optimum management is unknown, and closed follow-up is mandatory for clarification of this phenotype. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - May 2, 2019 Category: Biochemistry Source Type: research

Brazilian preschool children attending day care centers show an inadequate micronutrient intake through 24-hour duplicate diet
Publication date: Available online 30 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Isabelle Nogueira Leroux, Ana Paula Sacone da Silva Ferreira, Fernanda Pollo Paniz, Fábio Ferreira da Silva, Maciel Santos Luz, Bruno Lemos Batista, Dirce Maria Marchioni, Kelly Polido Kaneshiro OlympioAbstractInadequate micronutrient intake in childhood harms growth and development, and it is related to increased rates of morbidity and mortality. The aim of this study is to evaluate the dietary intake and prevalence of inadequate micronutrient intake in preschool children (1–4 years old) attendi...
Source: Journal of Trace Elements in Medicine and Biology - May 1, 2019 Category: Biochemistry Source Type: research

Systematic evaluation of exposure to trace elements and minerals in patients with chronic kidney disease of uncertain etiology (CKDu) in Sri Lanka
Publication date: Available online 29 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Shanika Nanayakkara, STMLD Senevirathna, Kouji H. Harada, Rohana Chandrajith, Toshiaki Hitomi, Tilak Abeysekera, Eri Muso, Takao Watanabe, Akio KoizumiAbstractChronic kidney disease of uncertain etiology (CKDu) in areas in and around Sri Lanka’s North Central Province has been identified as a major non-communicable disease due to its high prevalence and the burden on the public health system. Controversial evidence relating to the etiology and risk factors of CKDu has been reported. The most debated is ...
Source: Journal of Trace Elements in Medicine and Biology - May 1, 2019 Category: Biochemistry Source Type: research

Soil and indoor dust as environmental media of human exposure to As, Cd, Cu, and Pb near a copper smelter in central Chile
Publication date: Available online 29 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Maite Berasaluce, Pedro Mondaca, Marta Schuhmacher, Manuel Bravo, Sébastien Sauvé, Claudia Navarro-Villarroel, Elvira A. Dovletyarova, Alexander NeamanAbstractIn the present study, we assessed the non-carcinogenic and carcinogenic human health risk due to exposure to trace elements in soil and indoor dust in Puchuncaví valley. We also determined the associations between trace element concentration in hair/toenails and the estimated chronic daily intake of trace elements in soil and indoor...
Source: Journal of Trace Elements in Medicine and Biology - May 1, 2019 Category: Biochemistry Source Type: research

Lead poisoning due to Ingestion of Lead-contaminated Opium; A Diagnostic Study on Patients’ Imaging Findings
Publication date: Available online 25 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Nasim Zamani, Hossein Hassanian-Moghaddam, Hooman Bahrami-Motlagh, Sara Ahmadi, Scott PhillipsAbstractObjectivesOur study attempts to determine if for patients following ingestion of lead-contaminated opium, radiographs (plain X-ray (KUB)) or unenhanced computed tomography (CT scan) of the abdomen may be predictive of lead poisoning.MethodsOur study is concerned with patients of>21 years with elevated lead concentrations, who had undergone KUB or CT. Patients with other toxicities who had undergone similar...
Source: Journal of Trace Elements in Medicine and Biology - April 26, 2019 Category: Biochemistry Source Type: research

A novel functional role of nickel in sperm motility and eukaryotic cell growth
This study aims to investigate the relationship between seminal quality and ion levels in seminal plasma.Basic proceduresA total of 205 semen samples were collected and seminal plasma ion levels were examined with inductively-coupled plasma-mass spectrometry. The nickel function was demonstrated by in vitro assay and cell growth.Main findingsThe low sperm motility group showed distinctively reduced nickel concentration in seminal plasma compared with the normal sperm motility group. However, arsenic, sulfur, selenium, magnesium and zinc were negatively associated with sperm quality. No significant relationship between othe...
Source: Journal of Trace Elements in Medicine and Biology - April 26, 2019 Category: Biochemistry Source Type: research

Cobalt-chromium-enriched medium ameliorates shear-stressed endothelial cell performance
Publication date: Available online 24 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Mariana Issler Pinheiro Machado, Anderson Moreira Gomes, Marcel Ferreira Rodrigues, Thais Silva Pinto, Célio Júnior da Costa Fernandes, Fábio J. Bezerra, Willian Fernando ZambuzziABSTRACTAngiogenesis is a relevant mechanism to be considered for the success of bone healing, even considering endosseous implantable devices, providing adequate delivery of substances necessaries for the cell viability and bone de novo deposition. Within of the repertory of metal-based implantable alloys, cobal...
Source: Journal of Trace Elements in Medicine and Biology - April 25, 2019 Category: Biochemistry Source Type: research

A quick and simple method for the determination of six trace elements in mammalian serum samples using ICP-MS/MS
Publication date: Available online 24 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Johannes Florian Kopp, Sandra Marie Müller, Gabriele Pohl, Kristina Lossow, Anna Patricia Kipp, Tanja SchwerdtleAbstractIn order to assess the individual trace element status of humans for either medical or scientific purposes, amongst others, blood serum levels are determined. Furthermore, animal models are used to study interactions of trace elements. Most published methods require larger amounts (500-1000 µL) of serum to achieve a reliable determination of multiple trace elements. However...
Source: Journal of Trace Elements in Medicine and Biology - April 25, 2019 Category: Biochemistry Source Type: research

3-(4-Chlorophenylselanyl)-1-methyl-1H-indole promotes recovery of neuropathic pain and depressive-like behavior induced by partial constriction of the sciatic nerve in mice
In this study, we evaluate the anti-allodynic, anti-hyperalgesic and antidepressant-like effects of CMI on partial sciatic nerve ligation (PSNL) in male adult Swiss mice (25-35 g) as well as the involvement of oxidative stress in these effects. Mice underwent PSNL surgery and after 4 weeks they were treated with CMI (10 mg/kg, intragastric route [i.g.]) or vehicle. The treatment with CMI (10 mg/kg, i.g.) reversed the increased the percentage of response to Von-Frey Hair (VFH) stimulation, decreased the latency time to nociceptive response in the hot-plate test, increased immobility time in the forced s...
Source: Journal of Trace Elements in Medicine and Biology - April 25, 2019 Category: Biochemistry Source Type: research

Preventive Impacts of PAS-Na on the slow growth and activated inflammatory responses in Mn-exposed rats
ConclusionsPAS-Na could improve the growth retardation and alleviate inflammatory responses in Mn-exposed rats.Graphical abstract (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - April 25, 2019 Category: Biochemistry Source Type: research

Is maternal dietary selenium intake related to antioxidant status and the occurrence of pregnancy complications?
Publication date: Available online 19 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Pieczyńska Joanna, Płaczkowska Sylwia, Sozański Rafał, Orywal Karolina, Mroczko Barbara, Grajeta HalinaAbstractSelenium (Se) is a trace element essential for the appropriate course of vital processes in the human body. It is also a constituent of the active center of glutathione peroxidase and other antioxidant compounds which play an important role in red-ox processes. Associations between lower blood selenium concentration and obstetric complications has been reported in many studies. The aim of this st...
Source: Journal of Trace Elements in Medicine and Biology - April 20, 2019 Category: Biochemistry Source Type: research

Arsenic Exposure Through Drinking Water and Oxidative Stress Status: A Cross-sectional Study in the Ayeyarwady Region, Myanmar
Publication date: Available online 19 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Kyi Mar Wai, Masahiro Umezaki, Ohn Mar, Mitsutoshi Umemura, Chiho WatanabeAbstractArsenic is a well-known toxic heavy metal that is naturally dispersed in groundwater. Whereas arsenic is widely accepted to be involved in oxidative stress damage, little is known about arsenic-induced oxidative damage in relationship to contaminated drinking water as a source. The aim of this study was to determine the association between arsenic exposure through drinking water and oxidative stress status by measuring levels of...
Source: Journal of Trace Elements in Medicine and Biology - April 20, 2019 Category: Biochemistry Source Type: research

Quantitative imaging of platinum-based antitumor complexes in bone tissue samples using LA-ICP-MS
In this study, the platinum distribution in thin sections of mice tibia was determined using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) in a spatially resolved manner. The hard bone tissue visible in microscopic images and signals found for calcium and phosphorous recorded via LA-ICP-MS and micro X-ray fluorescence spectroscopy (µXRF) correlate well. Furthermore, the platinum concentration was quantified using polymer-based matrix-matched standards. A limit of detection of 6 µg/g and a linearity of almost three decades could be achieved. Concentrations surpassing 300 &...
Source: Journal of Trace Elements in Medicine and Biology - April 20, 2019 Category: Biochemistry Source Type: research

Rutin protects mercuric chloride‐induced nephrotoxicity via targeting of aquaporin 1 level, oxidative stress, apoptosis and inflammation in rats
Publication date: Available online 18 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Cuneyt Caglayan, Fatih Mehmet Kandemir, Serkan Yildirim, Sefa Kucukler, Gizem EserAbstractObjectiveMercury is a dangerous industrial and environmental pollutant which induces severe damage in diverse organs in animal and humans. The aim of this study was to investigate the protective effect of rutin (50 and 100 mg/kg body weight) against mercuric chloride (HgCl2) (1.23 mg/kg b.w.) toxicity in rats.MethodsThe experiment was carried out in male Sprague Dawley rats (n = 35) which was ...
Source: Journal of Trace Elements in Medicine and Biology - April 19, 2019 Category: Biochemistry Source Type: research

Cadmium, lead and mercury in Norwegian obese patients before and 12 months after bariatric surgery
Publication date: Available online 18 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Solveig Meyer Mikalsen, Anne-Lise Bjørke-Monsen, Trond Peder Flaten, Jon Elling Whist, Jan AasethAbstractPurposePrevious studies have suggested a role for the toxic elements lead (Pb), mercury (Hg) and cadmium (Cd) in the development of insulin resistance and hypertension. Increased blood Pb levels have been reported after bariatric surgery and weight loss. As about 80% of patients undergoing bariatric surgery are women, most of them of childbearing age, there are concerns regarding fetal exposure to t...
Source: Journal of Trace Elements in Medicine and Biology - April 19, 2019 Category: Biochemistry Source Type: research

Hair multi-bioelement profile of Kashin-Beck disease in the endemic regions of China
ConclusionsThese findings indicate that the interactions between elements do not represent a simple reciprocal relationship in the occurrence of KBD. In fact, KBD was associated with an imbalance in multiple elements that play a dynamic and interactive role in the development of the disease. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - April 17, 2019 Category: Biochemistry Source Type: research

Effects of platinum-based anticancer drugs on the trace element profile of liver and kidney tissue from mice
ConclusionsThe results indicate that the Pt-based agents investigated are major modulators of ion homeostasis in excretory organs, which most likely contributes to their systemic toxicity and limits their efficacy. A better understanding of subtle patterns and correlations among elements in key organs may provide deeper insights into the mechanisms of action and ultimately contribute for better, safer drugs. To achieve this goal, researchers involved in cancer drug development may leverage the high sensitivity and high sample throughput of ICP-MS, and the capabilities of modern statistical tools to extract relevant informa...
Source: Journal of Trace Elements in Medicine and Biology - April 13, 2019 Category: Biochemistry Source Type: research

Possibilities of single particle—ICP-MS for determining/characterizing titanium dioxide and silver nanoparticles in human urine
Publication date: July 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 54Author(s): Kamala Badalova, Paloma Herbello-Hermelo, Pilar Bermejo-Barrera, Antonio Moreda-PiñeiroAbstractObjectiveThe current use of nanoparticles in personal care and cosmetics, food safety, agriculture, medicine and pharmacy has led to a growing concern on the toxicity of these emerging materials to humans and also to the environment. Nanoparticles assessment (determination and size distribution) is a challenge mainly due to limitations of the current analytical instrumentation, but also because nanoparticles in foodstu...
Source: Journal of Trace Elements in Medicine and Biology - April 13, 2019 Category: Biochemistry Source Type: research

Childhood lead poisoning in Gaza Strip, the Palestinian Authority
Publication date: Available online 11 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Jamal M. Safi, Maged M. Yassin, Yasser Z. El-Nahhal, Yehia A. Abed, Mohamed J. Safi, Hassan D. SuleimanAbstractPurposeTo assess lead poisoning among a pediatric population in Gaza Strip, the Palestinian Authority.MethodsA total of 1705 questionnaires and blood samples were collected from children aged 2-6 years, by the finger stick capillary procedure, for the assessment of blood lead level (BLL), using the LeadCare kits. The samples were collected from children living close to lead processing units (hotspots...
Source: Journal of Trace Elements in Medicine and Biology - April 13, 2019 Category: Biochemistry Source Type: research

Possibilities of single particle – ICP-MS for determining/characterizing titanium dioxide and silver nanoparticles in human urine
Publication date: Available online 9 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Kamala Badalova, Paloma Herbello-Hermelo, Pilar Bermejo-Barrera, Antonio Moreda-PiñeiroAbstractObjectiveThe current use of nanoparticles in personal care and cosmetics, food safety, agriculture, medicine and pharmacy has led to a growing concern on the toxicity of these emerging materials to humans and also to the environment. Nanoparticles assessment (determination and size distribution) is a challenge mainly due to limitations of the current analytical instrumentation, but also because nanoparticles i...
Source: Journal of Trace Elements in Medicine and Biology - April 10, 2019 Category: Biochemistry Source Type: research

A urinary metabolomics study of a Polish subpopulation environmentally exposed to arsenic
Publication date: Available online 1 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Lucyna Kozłowska, Beata Janasik, Katarzyna Nowicka, Wojciech WąsowiczGraphical abstract (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - April 2, 2019 Category: Biochemistry Source Type: research

Titanium dioxide nanoparticles induce endothelial cell apoptosis via cell membrane oxidative damage and p38, PI3K/Akt, NF-κB signaling pathways modulation
ConclusionsTaken together, this study confirmed the effects of TiO2 NPs on endothelial cells and proposed multiple underlying mechanisms including cell membrane oxidative damage and intracellular processes.Graphical abstract (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - March 27, 2019 Category: Biochemistry Source Type: research

Editorial Board
Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - March 24, 2019 Category: Biochemistry Source Type: research

Lead and kidney: Concentrations, variabilities, and associations across the various stages of glomerular function
Publication date: Available online 15 March 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Ram B. JainAbstractData (N = 9882) from National Health and Nutrition Examination Survey for 2003-2014 for US adults aged ≥ 20 years were analyzed to evaluate the variabilities in concentrations of blood and urine lead across various stages of glomerular function. Those who had estimated glomerular filtration rate (eGFR)> 90 mL/min/1.73 m2 were defined to be in glomerular function stage 1 (GF-1), those who had eGFR between 60 and 90 mL/min/1.73 m2 were defined to be in...
Source: Journal of Trace Elements in Medicine and Biology - March 16, 2019 Category: Biochemistry Source Type: research

Placental levels of metals and associated factors in urban and sub-urban areas of Seville (Spain)
Publication date: Available online 12 March 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): L. Cerrillos, R. Fernández, M.J. Machado, I. Morillas, B. Dahiri, D. Gonzalez-Weller, A. Gutiérrez, C. Rubio, A. Hardisson, I. Moreno, A. Fernández-PalacínAbstractEnvironmental exposure to metals among women, revealed their adverse effects on pregnancy. The fetus is exposed to these toxic elements only via the placenta which are able to accumulate there or cross it, compromising the protective functions of this organ. Numerous studies have shown associations between the prenatal ex...
Source: Journal of Trace Elements in Medicine and Biology - March 13, 2019 Category: Biochemistry Source Type: research

Enhanced antibacterial activity of hemocyanin purified from Portunus pelagicus hemolymph combined with silver nanoparticles – intracellular uptake and mode of action
In this study, the crustacean immune protein hemocyanin (Pp-Hc, 78 kDa) purified from Portunus pelagicus hemolymph was used to fabricate silver nanoparticles. Characterization of hemocyanin-fabricated AgNPs (Pp-Hc AgNPs) were achieved using ultraviolet-visible spectrophotometer, X-ray powder diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), high-resolution-transmission electron microscopy (HR-TEM), and energy-dispersive X-ray spectroscopy. The antibacterial efficacy of AgNO3, Pp-Hc and Pp-Hc AgNPs was compared by growth inhibition, antibiofilm and live and dead analyses. Based on the results, Pp Hc ...
Source: Journal of Trace Elements in Medicine and Biology - March 12, 2019 Category: Biochemistry Source Type: research

Comparison of Aqueous and Enzymatic Extraction Combination with Sequential Filtration for the Profiling of Selected Trace Elements in Medicinal Plants from Kenya
Publication date: Available online 9 March 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): R. Mogwasi, D.K. Kariuki, M.Z. Getenga, V. NischwitzAbstractThis work presents results for the profiling of eight essential elements (Co, Cu, Ni, V, Mo, Mn, Zn and Cr) in aqueous and enzymatic extracts of eight anti-diabetic medicinal plants, used by Traditional Medicine Practitioners from Nyamira County, Kenya determined by ICP-MS. The plants used in the study were Solanum indicum, Plectranthus barbatus, Ultrica dioica, Bidens pilosa, Solanum mauense, Clerodendrum myricoides, Carissa edulis and Aloe vera. A s...
Source: Journal of Trace Elements in Medicine and Biology - March 10, 2019 Category: Biochemistry Source Type: research

ENVIRONMENTAL BORON EXPOSURE DOES NOT INDUCE DNA DAMAGE in LYMPHOCYTES and BUCCAL CELLS of FEMALES: DNA Damage in Lymphocytes and Buccal Cells of Boron Exposed Females
Publication date: Available online 9 March 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Nurşen Başaran, Yalçın Duydu, Aylin Üstündağ, Gökçe Taner, Sevtap Aydin Dilsiz, Hatice Gül Anlar, Can Özgür Yalçin, Merve Bacanli, Klaus golka, Tanja Schwerdtle, Hermann M. BoltAbstractBoron (B) compounds are essential for plants and animals and beneficial for humans in nutritional amounts. I animals and humans increasing evidence have shown beneficial effects on B compounds on nutrition and on antioxidant status. The genotoxic effects of environmental B e...
Source: Journal of Trace Elements in Medicine and Biology - March 9, 2019 Category: Biochemistry Source Type: research

The analysis of Cu, Mn and Zn content in prescription food for special medical purposes and modified milk products for newborns and infants available in Polish pharmacies from toxicological and nutritional point of view
ConclusionThe results show the occurrence of differences between the manufacturer’s declared composition and the finished product for consumption. The prescription FSMPs in comparison to MMPs available in Polish pharmacies contain similar levels of Cu, Mn and Zn. Our results show additionally that all of the products do not represent a health hazard to the newborns and infants. This is a pioneer study in terms of the safety assessment, and quality of prescription FSMPs and MMPs available in Polish pharmacies from toxicological and nutritional point of view.Graphical abstract (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - March 8, 2019 Category: Biochemistry Source Type: research

Selenium and selenium species in the etiology of Alzheimer’s dementia: the potential for bias of the case-control study design
Publication date: Available online 7 March 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Marco Vinceti, Bernhard Michalke, Carlotta Malagoli, Marcel Eichmüller, Tommaso Filippini, Manuela Tondelli, Annalisa Bargellini, Giulia Vinceti, Giovanna Zamboni, Annalisa ChiariAbstractSeveral human studies imply that the trace element selenium and its species may influence the onset of neurological disease, including Alzheimer’s dementia (AD). Nevertheless, the literature is conflicting, with reported associations between exposure and risk in opposite direction, possibly due to biases in exposure...
Source: Journal of Trace Elements in Medicine and Biology - March 8, 2019 Category: Biochemistry Source Type: research

Monitoring of salt iodisation programme in Iran; Health outcomes, shortages and perspective
Publication date: Available online 2 March 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Zheng Feei Ma, Yutong Zhang, Hang Zhou, Binyu Pan (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - March 4, 2019 Category: Biochemistry Source Type: research

Blood titanium level as a biomarker of orthopaedic implant wear
ConclusionDue to inter-laboratory analytical differences, reliable conclusions regarding “normal” and “abnormal” titanium levels in patients with orthopaedic implants are difficult to draw. Diagnosis of symptomatic patients should be based on radiographic evidence combined with blood/serum metal levels. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - March 1, 2019 Category: Biochemistry Source Type: research

Boron and pigment content in alfalfa affected by nano fertilization under calcareous conditions
The objectives were to investigate the effects of different boron treatments on alfalfa (Medicago sativa L.): 1) boron concentration, and 2) pigment contents including chlorophyll a, b, total, and carotenoids. Six regions with different properties were selected for the experiment; the soil samples were collected using GPS. The experimental treatments including: 1) soil type (S1-S6), 2) boron sources including boric acid (B1) and nano boron fertilization (B2), and 3) number of spraying (zero-, one-, two-, and three-time) were tested. The nano structure of boric acid-copper in an aqueous medium was produced using the chemica...
Source: Journal of Trace Elements in Medicine and Biology - March 1, 2019 Category: Biochemistry Source Type: research

The toxicological analysis of Cu, Mn and Zn as elemental impurities in pharmaceutical herbal products for teething available in pharmacies in Poland
This article describes the quantitative toxicological analysis of copper, manganese and zinc as EIs in the pharmaceutical gels for teething containing herbs available in Poland. The levels of EIs were measured to evaluate whether the intake of these metals through the gels was within recommended levels. The flame absorption spectrometry (FAAS) following microwave induced digestion (concentrated nitric acid) was applied to determine the levels of Cu, Mn and Zn in the products. This article was motivated especially by the facts that: (i) herbs can be a potential source of EIs; (ii) Cu, Mn and Zn are essential trace elements ...
Source: Journal of Trace Elements in Medicine and Biology - February 26, 2019 Category: Biochemistry Source Type: research

Sex-dependent expression of metallothioneins MT1 and MT2 and concentrations of trace elements in rat liver and kidney tissues: effect of gonadectomy
Publication date: Available online 23 February 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Marija Ljubojević, Tatjana Orct, Vedran Micek, Dean Karaica, Jasna Jurasović, Davorka Breljak, Ivana Vrhovac Madunić, Dubravka Rašić, Ivana Novak Jovanović, Maja Peraica, Marko Gerić, Goran Gajski, Saša Kralik Oguić, Dunja Rogić, Lucia Nanić, Ivica Rubelj, Ivan SabolićAbstractMetallothioneins (MTs) exhibit binding affinity for several essential and toxic trace elements. Previous studies in rodents indicated sex differences in the hepatic and renal expression of MTs and concentration...
Source: Journal of Trace Elements in Medicine and Biology - February 25, 2019 Category: Biochemistry Source Type: research

Assessing the dietary intake of calcium, magnesium, iron, zinc and copper in institutionalised children and adolescents from Guatemala. Contribution of nutritional supplements
Publication date: Available online 21 February 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): José Joaquín Muros, Carmen Cabrera-Vique, Mercedes Briones, Isabel SeiquerAbstractIn childhood and adolescence an adequate mineral intake is essential for normal growth and immune function, and to prevent chronic diseases in adulthood. The aim of this study was to analyse the dietary intake of Ca, Mg, Fe, Zn and Cu in children and adolescents from an orphanage-school in Guatemala and to assess the mineral contribution of nutritional supplements used by this population. Mineral content was ana...
Source: Journal of Trace Elements in Medicine and Biology - February 22, 2019 Category: Biochemistry Source Type: research

Chronic copper treatment prevents the liver critical balance transcription response induced by acetaminophen
Publication date: Available online 21 February 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Mauricio Latorre, Jason L. Burkhead, Christian Hodar, Miguel Arredondo, Mauricio González, Magdalena ArayaAbstractThe independent toxic effects of copper and acetaminophen are among the most studied topics in liver toxicity. Here, in an animal model of Cebus capucinus chronically exposed to high dietary copper, we assessed clinical and global transcriptional adaptations of the liver induced by a single high dose of acetaminophen. The experiment conditions were chosen to resemble a close to human rea...
Source: Journal of Trace Elements in Medicine and Biology - February 22, 2019 Category: Biochemistry Source Type: research