Morpho-functional alterations in lymphocytes and erythrocytes of Japanese quail due to prolonged in vivo exposure to heavy metal complexes
ConclusionThe toxicity of heavy metals leads to reduced maturation of the blast, which causes the appearance of immature cells in peripheral circulation and severe destruction of blood cell membranes. Erythrocyte hemolysis can lead to anemia, while lymphocyte damage can lead to lymphocytopenia. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - February 14, 2020 Category: Biochemistry Source Type: research

Chromium and human low-density lipoprotein oxidation
Publication date: May 2020Source: Journal of Trace Elements in Medicine and Biology, Volume 59Author(s): Domenico Lapenna, Giuliano CiofaniAbstractChromium is a catalytic metal able to foster oxidant damage, albeit its capacity to induce human LDL oxidation is to date unkown. Thus, we have investigated whether trivalent and hexavalent chromium, namely Cr(III) and Cr(VI), can induce human LDL oxidation. Cr(III) as CrCl3 is incapable of inducing LDL oxidation at pH 7.4 or 4.5. However, Cr(III), specifically at physiological pH of 7.4 and in the presence of phosphates, causes an absorbance increase at 234 resembling a spectro...
Source: Journal of Trace Elements in Medicine and Biology - February 13, 2020 Category: Biochemistry Source Type: research

Use of an antiarrhythmic drug against acute selenium toxicity
ConclusionThis study shows that amiodarone application has a reducing effect on selenium toxicity. This was because amiodarone protected the heart by reducing CK and CK-MB levels and increased vitamin B12 levels, which play a role in the synthesis of S-adenosyl methionine that converts selenium into a nontoxic form. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - January 29, 2020 Category: Biochemistry Source Type: research

Editorial Board
Publication date: March 2020Source: Journal of Trace Elements in Medicine and Biology, Volume 58Author(s): (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - January 23, 2020 Category: Biochemistry Source Type: research

Publisher's Note
Publication date: March 2020Source: Journal of Trace Elements in Medicine and Biology, Volume 58Author(s): (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - January 23, 2020 Category: Biochemistry Source Type: research

High serum concentration of selenium, but not calcium, cobalt, copper, iron, and magnesium, increased the risk of both hyperglycemia and dyslipidemia in adults: a health examination center based cross-sectional study
Publication date: Available online 14 January 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Aiping Liu, Ping Xu, Chunmei Gong, Yumei Zhu, Huimin Zhang, Wenjing Nie, Xiaoying Zhou, Xiongshun Liang, Yuanfei Xu, Changhua Huang, Xiao-Li Liu, Ji-Chang ZhouAbstractBackgroundMetabolic disorders of glucose and lipid were associated with some mineral elements, and data were warranted from various contexts to make the association more explicit.ObjectiveTo investigate the relationships between the serum concentrations of six mineral elements (calcium, cobalt, copper, iron, magnesium, and selenium) and the ri...
Source: Journal of Trace Elements in Medicine and Biology - January 15, 2020 Category: Biochemistry Source Type: research

Characterization of bone aluminum, a potential biomarker of cumulative exposure, within an occupational population from Zunyi, China
ConclusionsBone Al was significantly associated with 15-year Al CEI, but not other Al CEIs or fingernail Al. Bone Al may be a useful measure of cumulative, rather than short-term, Al exposure. Additional refinement of this method is ongoing.Graphical abstract (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - January 15, 2020 Category: Biochemistry Source Type: research

Chemical elements and preeclampsia - an overview of current problems, challenges and significance of recent research
Publication date: Available online 13 January 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Katarzyna Gajewska, Anna Błażewicz, Marzena Laskowska, Przemysław Niziński, Weronika Dymara - Konopka, Łukasz KomstaAbstractObjectivesData on the elemental status, redistribution of the elements, role of occupational exposure and dietary assessment in preeclampsia (PE) are scarce. There are many disparities in the findings of essential and non-essential elements’ role in PE. In this article we overview the changes in the content of selected elements in pregnancy complicated with the disorder of c...
Source: Journal of Trace Elements in Medicine and Biology - January 14, 2020 Category: Biochemistry Source Type: research

Association between trace elements in serum from bipolar disorder and schizophrenia patients considering treatment effects
Publication date: Available online 13 January 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Elisa C. Santa Cruz, Katherine C. Madrid, Marco A.Z. Arruda, Alessandra SussuliniAbstractBackgroundImbalances in metal concentrations have been suggested to contribute to the pathophysiology of different brain disorders, such as bipolar disorder (BD) and schizophrenia (SCZ).ObjectivesThe aim of this exploratory study is to evaluate the association between the concentrations of macro/trace elements in serum from BD and SCZ patients considering the effects from different treatments.MethodsEleven subjects with...
Source: Journal of Trace Elements in Medicine and Biology - January 14, 2020 Category: Biochemistry Source Type: research

Does selenium fortification of kale and kohlrabi sprouts change significantly their biochemical and cytotoxic properties?
ConclusionSe-fortified kale and kohlrabi sprouts are good candidates for functional food ingredients. Moreover, these results indicate that the sprouts enriched with sodium selenite show higher nutritional value, without significant changes in their cytotoxic activity. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - January 14, 2020 Category: Biochemistry Source Type: research

Colorectal cancer and trace elements alteration
ConclusionsSince this is the first such study in Balkan region, we assume that results of our study could be a good indicator of elemental alterations in colorectal cancer of Balkan population, due to similarity in lifestyle, dietary intake, pollution and exposure to toxic elements. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - January 12, 2020 Category: Biochemistry Source Type: research

Geographical and seasonal variation in Iodine content of cow’s milk in the UK and consequences for the consumer´s supply
Publication date: Available online 10 January 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Lisa J. Coneyworth, Lauren C.H.A. Coulthard, Elizabeth H. Bailey, Scott D. Young, Jonathan Stubberfield, Louise Parsons, Neil Saunders, Eamon Watson, Elizabeth M. Homer, Simon J.M. WelhamAbstractBackgroundDairy products provide a crucial source of dietary iodine for the majority of the UK population, contributing approximately 30-40 % of daily intake. Fluctuations in the iodine content of purchased milk both seasonally and annually implies potential fragility of iodine supply likely through fluctuating supp...
Source: Journal of Trace Elements in Medicine and Biology - January 11, 2020 Category: Biochemistry Source Type: research

Associations between manganese exposure and multiple immunological parameters in manganese-exposed workers healthy cohort
ConclusionsMn exposure from inhalable dust was associated with decreased complement C3 among occupationally Mn-exposed male individuals but not in female workers, which was further confirmed by the rat model. Further research into the possible mechanism of C3 reduction is needed in the future. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - January 11, 2020 Category: Biochemistry Source Type: research

Positive Association between Soil Arsenic Concentration and Mortality from Alzheimer’s Disease in Mainland China
ConclusionThere was an apparent soil As concentration dependent increase in AD mortality. Results of this study may provide evidence for a possible causal linkage between arsenic exposure and the death risk from AD. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - January 9, 2020 Category: Biochemistry Source Type: research

Inflammation factors and element supplementation in cancer
Publication date: Available online 8 January 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Małgorzata Jelińska, Dorota Skrajnowska, Małgorzata Wrzosek, Kamila Domanska, Wojciech Bielecki, Marta Zawistowska, Barbara Bobrowska KorczakAbstractThe aim of the study was to evaluate the effect of dietary supplementation with chosen minerals (Zn, Se, Fe) on expression of selected cytokines (IL-1, IL-6, TNFα) in spleen of rats and on their concentrations in rat serum under inflammatory and pathological conditions obtained by implantation of prostate cancer cells (LnCaP). Serum levels of metabolite...
Source: Journal of Trace Elements in Medicine and Biology - January 8, 2020 Category: Biochemistry Source Type: research

Editorial
Publication date: Available online 23 December 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Bernhard Michalke (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - December 24, 2019 Category: Biochemistry Source Type: research

Effect of silver doping on antidiabetic and antioxidant potential of ZnO nanorods
ConclusionsEnhanced inhibition of enzymes and scavenging of free radicals primarily responsible for reactive oxygen species (ROS) mediated damage, provide a strong scientific rationale for considering ZnO:Ag NR’s as a candidate nanomedicine for controlling postprandial hyperglycaemia and the associated oxidative stress. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - December 24, 2019 Category: Biochemistry Source Type: research

Effects of boric acid feeding on the oxidative stress parameters in testes, sperm parameters and DNA damage in mice
This study was aimed to determine the effects of boric acid on oxidative stress, testicular tissue and spermatozoon DNA. Experiments were performed with Swiss Albino mice divided equally into two groups based on the tratment period: one for 4 and the other for 6-week duration. These groups were further divided into subgroups as Control and those administered daily at oral doses of 115 mg/kg, 250 mg/kg and 450 mg/kg of boric acid. Then, testicular tissue were examined postmortem and analyzed using ex-vivo biochemical tools for oxidative stress, spermatozoon membrane integrity, sperm motility and live ce...
Source: Journal of Trace Elements in Medicine and Biology - December 18, 2019 Category: Biochemistry Source Type: research

Beneficial antioxidant status of piglets from sows fed selenomethionine compared with piglets from sows fed sodium selenite
ConclusionsMaternal supplementation with SeMet during gestation influenced hematology and clinical biochemistry in neonatal piglets in a different way than in offspring from sows receiving selenite enriched diets. Growth performance was positively influenced by both dietary Se source and Se level. Higher plasma levels of GPx3 observed in piglets receiving SeMet probably improved the protection against birth or growth related oxidative stress. These might prime the piglets for demanding situations as indicated by higher weight gain in offspring from sows fed with SeMet-supplemented diets. Our results on some enzyme activiti...
Source: Journal of Trace Elements in Medicine and Biology - December 10, 2019 Category: Biochemistry Source Type: research

Comparison of three oral selenium compounds in cancer patients: Evaluation of differential pharmacodynamic effects in normal and malignant cells
ConclusionsAt the 400 μg dose level no substantial changes in PD parameters were noted. Extrapolating from pre-clinical data, the dose examined in this cohort was too low to achieve the Se plasma concentration (≥ 5 μM) expected to elicit significant PD effects. Recruitment of a subsequent cohort at higher doses to exceed this PK threshold is planned. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - December 10, 2019 Category: Biochemistry Source Type: research

Serum zinc, copper, zinc-to-copper ratio, and other essential elements and minerals in children with attention deficit/hyperactivity disorder (ADHD)
The objective of the present study was to assess serum trace element and mineral levels in children with ADHD.MethodsSerum trace element and mineral levels in 68 children with ADHD and 68 neurotypical controls were assessed using ICP-MS at NexION 300D (PerkinElmer Inc., USA) equipped with ESI SC-2 DX4 autosampler (Elemental Scientific Inc., USA).ResultsSerum Cr, Mg, and Zn levels in children with ADHD were 21% (p = 0.010), 4% (p = 0.005), and 7% (p = 0. 001) lower as compared to the healthy controls, respectively. In turn, serum Cu/Zn values were 11% higher than those in the contro...
Source: Journal of Trace Elements in Medicine and Biology - December 7, 2019 Category: Biochemistry Source Type: research

Acute Exposure and Chronic Retention of Aluminum in Three Vaccine Schedules and Effects of Genetic and Environmental Variation
Publication date: Available online 5 December 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Grant McFarland, Elaine La Joie, Paul Thomas, James Lyons-WeilerAbstractLike the mechanisms of action as adjuvants, the pharmacodynamics of injected forms of aluminum commonly used in vaccines are not well-characterized, particularly with respect to how differences in schedules impact accumulation and how factors such as genetics and environmental influences on detoxification influence clearance. Previous modeling efforts are based on very little empirical data, with the model by Priest based on whole-body ...
Source: Journal of Trace Elements in Medicine and Biology - December 7, 2019 Category: Biochemistry Source Type: research

Lead-induced oxidative damage in rats/mice: A meta-analysis
Publication date: Available online 4 December 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Yongsheng Fan, Xue Zhao, Jun Yu, Jie Xie, Cong Li, Duanya Liu, Caoli Tang, Chunhong WangAbstractBackgroundLead (Pb) is ubiquitous in the environment and is an environmental genotoxic metal. Pb accumulation in the body could cause the oxidative stress.ObjectiveThis meta-analysis aimed to perform a systematic evaluation of the extent of oxidative damage in rats/mice induced by lead.MethodsAll relevant articles in English or Chinese were retrieved from Embase, PubMed, Web of Science, Medline, China National Kn...
Source: Journal of Trace Elements in Medicine and Biology - December 5, 2019 Category: Biochemistry Source Type: research

Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease
ConclusionsIn patients with CLD, anemia of inflammation and low serum hepcidin levels were found to paradoxically co-exist. Expression of duodenal proteins involved in iron absorption were either decreased or unaltered in these patients. The hepcidin response to higher body iron levels and/or inflammation appeared to be functional in these patients, despite the presence of liver disease. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 28, 2019 Category: Biochemistry Source Type: research

Chromium and human low-density lipoprotein oxidation: Running head: Cr and human LDL oxidation
Publication date: Available online 26 November 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Domenico Lapenna, Giuliano CiofaniABSTRACTChromium is a catalytic metal able to foster oxidant damage, albeit its capacity to induce human LDL oxidation is to date unkown. Thus, we have investigated whether trivalent and hexavalent chromium, namely Cr(III) and Cr(VI), can induce human LDL oxidation. Cr(III) as CrCl3 is incapable of inducing LDL oxidation at pH 7.4 or 4.5. However, Cr(III), specifically at physiological pH of 7.4 and in the presence of phosphates, causes an absorbance increase at 234 resemb...
Source: Journal of Trace Elements in Medicine and Biology - November 28, 2019 Category: Biochemistry Source Type: research

Metalloproteomics analysis in human mammary cell lines treated with inorganic mercury
Publication date: Available online 23 November 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Mariángeles Ávila Maniero, Rodolfo G. Wuilloud, Eduardo A. Callegari, Patricia N. Smichowski, Mariel A. FanelliAbstractThe interest in inorganic Hg toxicity and carcinogenicity has been pointed to target organs such as kidney, brain or placenta, but only a few studies have focused on the mammary gland. In this work, analytical combination techniques (SDS-PAGE followed by CV-AFS, and nanoUPLC-ESI-MS/MS) were used to determine proteins that could bind Hg in three human mammary cell lines. Two o...
Source: Journal of Trace Elements in Medicine and Biology - November 25, 2019 Category: Biochemistry Source Type: research

Editorial Board
Publication date: January 2020Source: Journal of Trace Elements in Medicine and Biology, Volume 57Author(s): (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 20, 2019 Category: Biochemistry Source Type: research

Dynamics of trace metals in the system water – soil – plant – wild rats – tapeworms (Hymenolepis diminuta) in Maglizh area, Bulgaria
ConclusionsExperimentally established bioaccumulation of trace metals in the studied vegetation and rats is a consequence of the total concentration of trace metals in waters and soils, their mobility and chemical species. The dominance of organic complexes of trace metals is a prerequisite for their bioaccumulation in plants. Rats are in direct contact with the soil solution and therefore, of importance is the content of free ions of Mn2+, Ni2+, Zn2+, which are easily absorbed through the skin. The host-helminth system wild rat / H. diminuta could be used as a bioindicator for trace metals pollution.Graphical abstract (So...
Source: Journal of Trace Elements in Medicine and Biology - November 16, 2019 Category: Biochemistry Source Type: research

Copper and selenium status as biomarkers of neonatal infections
Publication date: Available online 15 November 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Julian Hackler, Monika Wisniewska, Lennart Greifenstein-Wiehe, Waldemar B. Minich, Malte Cremer, Christoph Bührer, Lutz SchomburgAbstractNeonatal infections are a major risk factor for neonatal mortality. A reliable diagnosis of early-onset sepsis (EOS) is hampered by the variable clinical presentations of the children. We hypothesized that changes in the Se or Cu status, or the biomarkers selenoprotein P (SELENOP) or ceruloplasmin (CP) alone or in combination may be informative of EOS.We generated a ...
Source: Journal of Trace Elements in Medicine and Biology - November 16, 2019 Category: Biochemistry Source Type: research

Beneficial antioxidant status of piglets from sows fed selenomethionine compared with those fed sodium selenite
ConclusionsMaternal supplementation with SeMet during gestation influenced hematology and clinical biochemistry in neonatal piglets in a different way than in offspring from sows receiving selenite enriched diets. Growth performance was positively influenced by both dietary Se source and Se level. Higher plasma levels of GPx3 observed in piglets receiving SeMet probably improved the protection against birth or growth related oxidative stress. These might prime the piglets for demanding situations as indicated by higher weight gain in offspring from sows fed with SeMet-supplemented diets. Our results on some enzyme activiti...
Source: Journal of Trace Elements in Medicine and Biology - November 16, 2019 Category: Biochemistry Source Type: research

Assessment of copper, iron, zinc and manganese status and speciation in patients with Parkinson’s disease: A pilot study
ConclusionsMetal speciation is significantly affected in serum of PD-patients. These findings are indicative of the potential role of metal metabolism and PD pathogenesis, although the exact mechanisms of such associations require further detailed studies. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 15, 2019 Category: Biochemistry Source Type: research

High-precision iron isotope analysis of whole blood, erythrocytes, and serum in adults
This study aimed to establish an analytical method for high-precision Fe isotopic measurement, investigate Fe concentration and isotopic composition in different parts of whole blood, and explore the potential of Fe isotopic composition as an indicator for Fe status within individuals.Analytical methodsA total of 23 clinically healthy Taiwanese adults of Han descent were enrolled randomly and Fe isotopic compositions of their whole blood, erythrocytes, and serum were measured. The Fe isotopic analysis was performed by Neptune Plus multiple-collector inductively coupled plasma mass spectrometry with double-spike technique. ...
Source: Journal of Trace Elements in Medicine and Biology - November 15, 2019 Category: Biochemistry Source Type: research

The effects of chromium picolinate on glucose and lipid metabolism in running rats
Publication date: Available online 12 November 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Ragip Pala, Mehmet Akif Sari, Fusun Erten, Besir Er, Mehmet Tuzcu, Cemal Orhan, Patrick Brice Defo Deeh, Nurhan Sahin, Vedat Cinar, James R. Komorowski, Kazim SahinABSTRACTBackgroundChromium picolinate (CrPic) is commonly used to reduce muscle fatigue after exercise. We aimed to elucidate the effects of CrPic on glucose and lipid metabolism and the expression of glucose transporters in exercised rats.MethodsForty-two male Wistar rats (8-week-old) were distributed into six groups (n = 7) as fo...
Source: Journal of Trace Elements in Medicine and Biology - November 13, 2019 Category: Biochemistry Source Type: research

Effect of acute sodium nitrite intoxication on some essential biometals in mouse spleen
ConclusionThe results of the present study demonstrate that acute NaNO2 intoxication provokes changes in the endogenous levels of Fe, Ca and Zn in mouse spleen. These findings suggest disruption of the ionic balance and impact on the activity of antioxidant defence enzymes. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 13, 2019 Category: Biochemistry Source Type: research

Association of Circulating Selenium Concentration with Dyslipidemia: Results From the NHANES
ConclusionsHigher circulating selenium levels had non-linear association with lipid profiles and the increased odds of dyslipidemia. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 13, 2019 Category: Biochemistry Source Type: research

Association of iron levels in hair with brain structures and functions in young adults
CONCLUSIONThese results are compatible with the notion that iron plays diverse roles in neural mechanisms in healthy young adults. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 13, 2019 Category: Biochemistry Source Type: research

Acute human toxicity and mortality after selenium ingestion: a review
ConclusionThe acute toxicity associated with oral selenium ingestion and the blood and urinary levels of selenium in different cases of poisonings were reviewed. Mortality is a risk of acute selenium poisoning. Concentrations of selenium in blood and urine samples in non-fatal cases are close to those observed in fatal cases. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 13, 2019 Category: Biochemistry Source Type: research

Blood Lead in Children and Associations with Trace Elements and Sociodemographic Factors
Publication date: Available online 7 November 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Ángeles Martínez-Hernanz, Montserrat González-Estecha, María Blanco, Manuel Fuentes, José María Ordóñez-Iriarte, Irene Palazón-Bru, Elpidio Calvo-Manuel, Andrés Bodas-PinedoAbstractBackgroundNo safe blood lead concentration in children has been identified. Lead can affect nearly every system in the body and is especially harmful to the developing central nervous system of children.The aim of this study is to analyze blood lead in a popula...
Source: Journal of Trace Elements in Medicine and Biology - November 9, 2019 Category: Biochemistry Source Type: research

Molecular characterization of ten zinc (Zn) transporter genes and their regulation to Zn metabolism in freshwater teleost yellow catfish Pelteobagrus fulvidraco
ConclusionFor the first time, our study characterized ten ZIP family members in yellow catfish, explored their mRNA tissue expression. Their regulation to Zn addition were also investigated in the hepatocytes and intestinal epithelial cells of yellow catfish. Our study revealed the mechanism of cells exposed to Zn addition and provided novel insights for the regulatory mechanism of Zn homeostasis. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 9, 2019 Category: Biochemistry Source Type: research

Presence and possible origin of positive Eu anomaly in shoot samples of Juncus effusus L
ConclusionAll samples showed positive europium anomalies in NASC-normalized REE concentration patterns. The most probable explanation of this is that the uptake and translocation of Eu inJ. effusus (and possibly in other wetland plants) is caused by a short-term decrease of the redox potential in a rhizosphere favoring reduction of Eu3+ to Eu2+ and thus enhancing Eu mobility in the soil-plant environment.Graphical abstract (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 7, 2019 Category: Biochemistry Source Type: research

Iodine intake among children and adolescents in Norway: Estimates from the national dietary survey Ungkost 3 (2015-2016)
ConclusionsWe have shown that the estimated risk of suboptimal usual iodine intakes among children and adolescents in Norway varies according to age, sex, maternal educational level and area of residence. Those with a limited intake of the main dietary contributors to iodine intake may be at risk, and adolescent girls seem to be especially vulnerable. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 7, 2019 Category: Biochemistry Source Type: research

Cross-sectional analysis of trace element status in thyroid disease
Publication date: Available online 6 November 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Sebastian Mehl, Qian Sun, Christian L. Görlich, Julian Hackler, Johannes F. Kopp, Kostja Renko, Jens Mittag, Tanja Schwerdtle, Lutz SchomburgAbstractBackgroundThe synthesis of thyroid hormone depends on a set of trace elements, most importantly selenium and iodine. The dietary supply with certain micronutrients is limited in many areas of the world, including central Europe and large parts of Asia and Africa. Moreover, both thyroid disease risk and therapy effects are modulated by trace element supply ...
Source: Journal of Trace Elements in Medicine and Biology - November 6, 2019 Category: Biochemistry Source Type: research

The concentration of selected elements in the placenta according to selected sociodemographic factors and their effect on birth mass and birth length of newborns
ConclusionsSmoking during pregnancy and environment pollution are the factors that affects the concentration of elements in the placenta and contributes to their high accumulation in the placenta. Smoking during pregnancy causes an increased concentration of cadmium in the placenta which has negative health effects for the newborn. Women living in a big city or village had a higher concentration of cadmium in their placentas compared to women living in smaller cities. The significant influence of some elements (K, Fe, Zn, Cu and Cd) on the newborn’s birth parameters was also demonstrated. The results of our research ...
Source: Journal of Trace Elements in Medicine and Biology - November 6, 2019 Category: Biochemistry Source Type: research

Se-methylselenocysteine stimulates migration and antioxidant response in HaCaT keratinocytes: Implications for wound healing
ConclusionOur results suggest that MSC can promote skin wound healing by stimulating keratinocyte migration and, moreover, can protect cells from excessive oxidative stress that often accompanies and impairs the wound healing process, particularly in chronic wounds, by stimulating an antioxidant response. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 6, 2019 Category: Biochemistry Source Type: research

Assessment of the nutritional value of various teas infusions in terms of the macro- and trace elements content
ConclusionsGenerally, the infusions of herbal teas to a small extent cover the daily allowance for elements, however they are a valuable complementary source of them. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 4, 2019 Category: Biochemistry Source Type: research

Comparative study on the effects of salinomycin, monensin and meso-2,3-dimercaptosuccinic acid on the concentrations of lead, calcium, copper, iron and zinc in lungs and heart in lead-exposed mice
ConclusionThe results demonstrated the potential application of polyether ionophorous antibiotic salinomycin as antidote for treatment of Pb-induced toxicity in the lungs and heart. The possible complexation of the polyether ionophorous antibiotics with Ca(II) and Zn(II), which can diminish the endogenous concentrations of both ions in the lungs should be taken into account. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 3, 2019 Category: Biochemistry Source Type: research

Role of Trace Elements in Pityriasis Alba
ConclusionPA is associated with reduced levels of Hb, serum zinc, ferritin, copper and magnesium; sun exposure, skin phototype were found to be important risk factors for PA. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - October 31, 2019 Category: Biochemistry Source Type: research

Assessment of copper, iron, zinc and manganese status and speciation in patients with Parkinson's disease: a pilot study
ConclusionsMetal speciation is significantly affected in serum of PD-patients. These findings are indicative of the potential role of metal metabolism and PD pathogenesis, although the exact mechanisms of such associations require further detailed studies. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - October 29, 2019 Category: Biochemistry Source Type: research

The spectrum of pathogenic variants of the ATP7B gene in Wilson disease in the Russian Federation
The objective of the present study was estimation of the frequency of ATP7B gene mutations in the Russian population of WD patients. Materials and methods. 75 WDpatients were examined by next-generation sequencing (NGS). A targeted panel NimbleGen SeqCap EZ Choice: 151012_HG38_CysFib_EZ_HX3 (ROCHE)was designed for analysis of ATP7B gene and possible modifier genes. Retrospective assessment of a diagnostic WD score (Leipzig, 2001) was also performed. Results. 31 mutations in ATP7B gene were detected. Two most frequent mutations were c.3207C > A (51,85% of alleles) and c.3190 G > A (8...
Source: Journal of Trace Elements in Medicine and Biology - October 26, 2019 Category: Biochemistry Source Type: research

Elemental metabolomics in human cord blood: Method validation and trace element quantification
This study used an Agilent 7900 inductively coupled plasma mass spectrometer (ICP-MS) to simultaneously measure 68 elements, in 166 placental cord blood samples collected from women with various pregnancy complications (control, hypertensive, PE, GDM, FGR, pre-term, and post-term birth).ResultsThere were single element differences across gestational outcomes for elements Mg, P, Cr, Ni, Sr, Mo, I, Au, Pb, and U. Hypertensive and post-term pregnancies were significantly higher in Ni concentrations when compared to controls (control = 2.74 µg/L, hypertensive = 6.72 µg/L, p...
Source: Journal of Trace Elements in Medicine and Biology - October 25, 2019 Category: Biochemistry Source Type: research