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Nutrition: Calcium
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Total 1776 results found since Jan 2013.
Effect of acupuncture on sleep quality and neurological function in stroke patients with sleep apnea syndrome
CONCLUSION: Western medicine treatment combined with acupuncture can significantly relieve the clinical symptoms of stroke patients with SAS and improve sleep quality and neurological function. Therefore, it is worthy of clinical application.PMID:34150169 | PMC:PMC8205691
Source: American Journal of Translational Research - June 21, 2021 Category: Research Authors: Peng Zhang Lingsu Cheng Qian Tian Guang Chen Chao Chen Junfeng Xu Source Type: research
Arterial Calcification and Its Association With Stroke: Implication of Risk, Prognosis, Treatment Response, and Prevention
Front Cell Neurosci. 2022 May 11;16:845215. doi: 10.3389/fncel.2022.845215. eCollection 2022.ABSTRACTStroke is a leading cause of death worldwide. Vascular calcification (VC), defined as deposition of calcium-phosphate complexes in the vessels, is considered as the characteristic of vascular aging. Calcifications at different vessel layers have different implications. Intimal calcification is closely related to atherosclerosis and affects plaque stability, while medial calcification can cause arterial stiffening and reduce compliance. Accumulating evidence suggested that arterial calcifications, including calcifications in...
Source: Atherosclerosis - May 31, 2022 Category: Cardiology Authors: Xiang Wang Xinghang Chen Zhuohui Chen Mengqi Zhang Source Type: research
Crocins for Ischemic Stroke: A Review of Current Evidence
Crocins (CRs) and the related active constituents derived from Crocus sativus L. (Saffron) have demonstrated protective effects against cerebral ischemia and ischemic stroke, with various bioactivities including neuroprotection, anti-neuroinflammation, antioxidant, and cardiovascular protection. Among CRs, crocin (CR) has been shown to act on multiple mechanisms and signaling pathways involved in ischemic stroke, including mitochondrial apoptosis, nuclear factor kappa light chain enhancer of B cells pathway, S100 calcium-binding protein B, interleukin-6 and vascular endothelial growth factor-A. CR is generally safe and wel...
Source: Frontiers in Pharmacology - August 5, 2022 Category: Drugs & Pharmacology Source Type: research
The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination
This study explores the relationship between HECTD4, GluN2B, and MALT1, focusing on their role in brain injury in ischemic stroke. Rats were subjected to 2 h-ischemia followed by 24-h reperfusion to establish an ischemic stroke model. We observed the downregulation of HECTD4 and the upregulation of MALT1. Additionally, an increased GluN2B phosphorylation was concomitant with weakened interactions between HECTD4 and GluN2B, followed by decreased stria tal-enriched protein phosphatase (STEP61). Knockdown of HECTD4 exacerbated hypoxia- or NMDA-induced injury in nerve cells coincident with a decrease in GluN2B and MALT1 ubiq...
Source: Molecular Neurobiology - February 4, 2023 Category: Neurology Source Type: research
Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery disease
ConclusionThe frequency of coronary calcification was higher in subjects with stroke caused by large-artery atherosclerosis than in controls.
Source: Frontiers in Neurology - April 12, 2023 Category: Neurology Source Type: research
Repurposing the K < sub > Ca < /sub > 3.1 Blocker Senicapoc for Ischemic Stroke
Transl Stroke Res. 2023 Apr 24. doi: 10.1007/s12975-023-01152-6. Online ahead of print.ABSTRACTSenicapoc, a small molecule inhibitor of the calcium-activated potassium channel KCa3.1, was safe and well-tolerated in clinical trials for sickle cell anemia. We previously reported proof-of-concept data suggesting that both pharmacological inhibition and genetic deletion of KCa3.1 reduces infarction and improves neurologic recovery in rodents by attenuating neuroinflammation. Here we evaluated the potential of repurposing senicapoc for ischemic stroke. In cultured microglia, senicapoc inhibited KCa3.1 currents with an IC50 of 7...
Source: Cell Research - April 24, 2023 Category: Cytology Authors: Ruth D Lee Yi-Je Chen Hai M Nguyen Latika Singh Connor J Dietrich Benjamin R Pyles Yanjun Cui Jonathan R Weinstein Heike Wulff Source Type: research
Quantitative CTA vascular calcification, atherosclerosis burden, and stroke mechanism in patients with ischemic stroke
Vascular calcification is recognized as the advanced stage of atherosclerosis burden. We hypothesized that vascular calcium quantification in CT angiography (CTA) would be helpful to differentiate large artery atherosclerosis (LAA) from other stroke etiology in patients with ischemic stroke.
Source: Journal of the Neurological Sciences - April 28, 2023 Category: Neurology Authors: Takashi Shimoyama, Sibaji Gaj, Kunio Nakamura, Shivakrishna Kovi, Shumei Man, Ken Uchino Source Type: research
Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery disease
CONCLUSION: The frequency of coronary calcification was higher in subjects with stroke caused by large-artery atherosclerosis than in controls.PMID:37122290 | PMC:PMC10130387 | DOI:10.3389/fneur.2023.1082275
Source: Atherosclerosis - May 1, 2023 Category: Cardiology Authors: Ana Lu íza Vieira de Araújo Raul D Santos Marcio Sommer Bittencourt Roberto Nery Dantas Carlos Andr é Oshiro Cesar Higa Nomura Edson Bor-Seng-Shu Marcelo de Lima Oliveira Claudia da Costa Leite Maria da Gra ça Morais Martin Maramelia Miranda Alves Gis Source Type: research
Retinal stroke: research models, targets and experimental drugs
Expert Opin Investig Drugs. 2023 Aug 31. doi: 10.1080/13543784.2023.2254688. Online ahead of print.ABSTRACTINTRODUCTION: Retinal artery occlusion (RAO), often caused by a microembolus and resulting in inner retinal ischemia, could be considered as the retinal analogue to cerebral stroke. Although several therapeutic targets have been suggested in animal models of retinal ischemia and several potential treatments have been evaluated on small series of patients, central retinal artery occlusion (CRAO) is still rarely treatable in clinical practice.AREAS COVERED: Here, we review several animal models of RAO, including increas...
Source: Expert Opinion on Investigational Drugs - August 31, 2023 Category: Drugs & Pharmacology Authors: Alejandra Daruich Matthieu P Robert Marta Zola Alexandre Matet Dominique Bremond-Gignac Source Type: research
Coronary Calcium Predicts Stroke RiskCoronary Calcium Predicts Stroke Risk
CAC predicted stroke in both men and women independently of the presence of atrial fibrillation or Framingham risk factors. It was more predictive in persons younger than 65 years and in those at relatively low cardiovascular risk. Medscape Medical News
Source: Medscape Today Headlines - March 1, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
Stroke in Primary Hyperoxaluria Type I
We report the case of a 27‐year‐old man with a history of previously undiagnosed renal disease that presented with multiple cerebrovascular infarctions. Workup for traditional causes of cerebrovascular infarction including cardiac telemetry, multiple echocardiograms, and hypercoagulative workup was negative. However, a transcranial Doppler detected circulating microemboli at the rate of 14 per hour. A serum oxalate level greater than the supersaturation point of calcium oxalate was detected, providing a potential source of the microemboli. Furthermore, serial imaging recorded rapid mineralization of the infarcted terri...
Source: Journal of Neuroimaging - April 2, 2013 Category: Radiology Authors: Neal M. Rao, Anil Yallapragada, Kellen D. Winden, Jeffrey Saver, David S. Liebeskind Tags: Case Report Source Type: research
