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Nutrition: Calcium

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Total 1776 results found since Jan 2013.

Lithium enhances post-stroke blood-brain barrier integrity, activates the MAPK/ERK1/2 pathway and alters immune cell migration in mice.
In conclusion, we demonstrate for the first time that lithium is able to enhance post-stroke BBB integrity. Importantly, our work delivers novel insights into the exact mechanism of lithium-induced acute neuroprotection, providing critical information for future clinical trials involving lithium treatment in stroke patients. PMID: 33065166 [PubMed - as supplied by publisher]
Source: Neuropharmacology - October 13, 2020 Category: Drugs & Pharmacology Authors: Haupt M, Zechmeister B, Bosche B, Lieschke S, Zheng X, Zhang L, Venkataramani V, Jin F, Hein K, Weber MS, Hermann DM, Bähr M, Doeppner TR Tags: Neuropharmacology Source Type: research

TRPM2 in ischemic stroke: Structure, molecular mechanisms, and drug intervention.
Authors: Wang Q, Liu N, Ni YS, Yang JM, Ma L, Lan XB, Wu J, Niu JG, Yu JQ Abstract Ischemic stroke has a high lethality rate worldwide, and novel treatments are limited. Calcium overload is considered to be one of the mechanisms of cerebral ischemia. Transient receptor potential melastatin 2 (TRPM2) is a reactive oxygen species (ROS)-sensitive calcium channel. Cerebral ischemia-induced TRPM2 activation triggers abnormal intracellular Ca2+ accumulation and cell death, which in turn causes irreversible brain damage. Thus, TRPM2 has emerged as a new therapeutic target for ischemic stroke. This review provides data on ...
Source: Channels - January 21, 2021 Category: Molecular Biology Tags: Channels (Austin) Source Type: research

Role of Calcium Homeostasis in Ischemic Stroke: A Review.
Abstract Stroke is the second most common cause of death worldwide. It occurs due to the insufficient supply of oxygen-rich blood to the brain. It is a complex disease with multiple associated risk factors including smoking, alcoholism, age, sex, ethnicity, etc. Calcium ions are known to play a vital role in cell death pathways, which is a ubiquitous intracellular messenger during and immediately after an ischemic period. Disruption in normal calcium hemostasis is known to be a major initiator and activator of the ischemic cell death pathway. Under Ischemic stroke conditions, glutamate is released from the neurons...
Source: CNS and Neurological Disorders Drug Targets - February 12, 2021 Category: Drugs & Pharmacology Authors: Ludhiadch A, Sharma R, Muriki A, Munshi A Tags: CNS Neurol Disord Drug Targets Source Type: research

Olive oil consumption is associated with a lower risk of cardiovascular disease and stroke
CONCLUSIONS: Olive oil is associated with lower risk of CVD and stroke. The maximum benefit could be obtained with a consumption between 20 and 30 g/day. The association could be stronger for virgin olive oil and might operate from the early stages of the disease.PMID:34872046 | DOI:10.1016/j.clnu.2021.11.002
Source: Atherosclerosis - December 6, 2021 Category: Cardiology Authors: Carolina Donat-Vargas Helena Sandoval-Insausti Jos é L Peñalvo Maria Concepci ón Moreno Iribas Pilar Amiano Maira Bes-Rastrollo Esther Molina-Montes Bel én Moreno-Franco Antonio Agudo Cristina Lasheras Mayo Mart ín Laclaustra Carmen De La Fuente Arri Source Type: research

Association between Fok1 and TaqI polymorphisms of vitamin D receptor gene with the severity of stenosis and calcification in carotid bulb in patients with ischemic stroke
CONCLUSIONS: There may be a biological association between the FokI VDR gene and carotid bulb calcification.PMID:35091316 | DOI:10.1016/j.jocn.2022.01.009
Source: Atherosclerosis - January 29, 2022 Category: Cardiology Authors: Farzaneh Foroughinia Najmeh Morovati Anahid Safari Mehdi Dianatpour Iman Jamhiri Seyed Taghi Heydari Sedighe Hooshmandi Afshin Borhani-Haghighi Source Type: research

Molecules, Vol. 27, Pages 5488: The Effect of a New N-hetero Cycle Derivative on Behavior and Inflammation against the Background of Ischemic Stroke
Kiseleva Vadim V. Negrebetsky Yuri I. Baukov Ischemic stroke triggers a whole cascade of pathological changes in the brain, one of which is postischemic inflammation. Since in such cases thrombolytic therapy is often not possible, methods that modulate inflammation and affect microglia become particularly interesting. We synthesized 3-(2-oxo-4-phenylpyrrolidin-1-yl)propane-1-sulfonate calcium(II) (Compound 4) and studied its anti-inflammatory activity in in vitro and in vivo models of inflammation and ischemia. Macrophage cell line RAW 264.7 was treated with lipopolysaccharides (LPS) and Compound 4 at various dosa...
Source: Molecules - August 26, 2022 Category: Chemistry Authors: Denis A. Borozdenko Tatiana A. Shmigol Aiarpi A. Ezdoglian Darya I. Gonchar Natalia. Y. Karpechenko Dmitri N. Lyakhmun Anastasia D. Shagina Elvira A. Cherkashova Daria D. Namestnikova Ilya L. Gubskiy Anastasia A. Chernysheva Nina M. Kiseleva Vadim V. Negr Tags: Article Source Type: research

Transient receptor potential ion channels and cerebral stroke
ConclusionsAlthough the precise mechanism of transient receptor potential ion channels in cerebral stroke is still unclear, it has the potential to be a therapeutic target for patients with stroke if developed appropriately. Hence, more research is needed to prove its efficacy in this context.
Source: Brain and Behavior - December 17, 2022 Category: Neurology Authors: Qin'yi Xu, Yan Zou, Zeng'li Miao, Lei Jiang, Xu'dong Zhao Tags: REVIEW Source Type: research

Epigenetics and stroke: role of DNA methylation and effect of aging on blood-brain barrier recovery
This study aimed to evaluate the epigenetic and transcriptional profile of cerebral microvessels after thromboembolic (TE) stroke to define potential causes of limited BBB recovery. RNA-sequencing and reduced representation bisulfite sequencing (RRBS) analyses were performed using microvessels isolated from young (6 months) and old (18 months) mice seven days poststroke compared to age-matched sham controls. DNA methylation profiling of poststroke brain microvessels revealed 11287 differentially methylated regions (DMR) in old and 9818 DMR in young mice, corresponding to annotated genes. These DMR were enriched in genes en...
Source: Cell Research - January 30, 2023 Category: Cytology Authors: Chelsea Phillips Svetlana Stamatovic Richard Keep Anuska Andjelkovic Source Type: research

Epigenetics and stroke: role of DNA methylation and effect of aging on blood –brain barrier recovery
This study aimed to evaluate the epigenetic and transcriptiona l profile of cerebral microvessels after thromboembolic (TE) stroke to define potential causes of limited BBB recovery. RNA-sequencing and reduced representation bisulfite sequencing (RRBS) analyses were performed using microvessels isolated from young (6 months) and old (18 months) mice seven day s poststroke compared to age-matched sham controls. DNA methylation profiling of poststroke brain microvessels revealed 11,287 differentially methylated regions (DMR) in old and 9818 DMR in young mice, corresponding to annotated genes. These DMR were enriched in gen...
Source: Fluids and Barriers of the CNS - February 28, 2023 Category: Neuroscience Source Type: research

Subclinical Vascular Composites Predict Clinical Cardiovascular Disease, Stroke, and Dementia: The Multi-Ethnic Study of Atherosclerosis (MESA)
CONCLUSIONS: Subclinical vascular composites of arteriosclerosis and atherosclerosis may be useful biomarkers to inform the vascular pathways contributing to events of CVD, CHD, stroke, and dementia.PMID:37205504 | PMC:PMC10187443 | DOI:10.1101/2023.05.01.23289364
Source: Atherosclerosis - May 19, 2023 Category: Cardiology Authors: Timothy M Hughes Jordan Tanley Haiying Chen Christopher L Schaich Joseph Yeboah Mark A Espeland Joao A C Lima Bharath Ambale-Venkatesh Erin D Michos Jingzhong Ding Kathleen Hayden Ramon Casanova Suzanne Craft Stephen R Rapp Jos é A Luchsinger Annette L F Source Type: research

Interpretable machine learning for predicting 28-day all-cause in-hospital mortality for hypertensive ischemic or hemorrhagic stroke patients in the ICU: a multi-center retrospective cohort study with internal and external cross-validation
ConclusionsThe XGBoost model accurately predicted 28-day all-cause in-hospital mortality among hypertensive ischemic or hemorrhagic stroke patients admitted to the ICU. The SHAP method can provide explicit explanations of personalized risk prediction, which can aid physicians in understanding the model.
Source: Frontiers in Neurology - August 8, 2023 Category: Neurology Source Type: research

Meta-analysis of effects of calcium channel blockers in prevention of stroke in adults with hypertension
Source: PLoS One Area: News The specific effects of calcium channel blockers (CCBs) against stroke in patients with hypertension as compared to no treatment and other antihypertensive drug classes are not known.   A systematic review and meta-analysis of data from 273,543 participants in 31 RCTs was conducted to evaluate the efficacy of CCBs on stroke in patients with hypertension in studies of CCBs versus placebo, ACE inhibitors (ACEIs), ?-adrenergic blockers, and diuretics.   A literature search to July 31, 2012 identified 31 RCTs with 273,543 participants (including 130,466 experimental subjects and 1...
Source: NeLM - Cardiovascular Medicine - March 21, 2013 Category: Cardiology Source Type: news

Ischemic Stroke: Measurement of Intracranial Artery Calcifications Can Improve Prediction of Asymptomatic Coronary Artery Disease Neuroradiology
Conclusion: The IAC scores quantified by using unenhanced CT correlate significantly with coronary calcium scores and may serve as an independent predictor of asymptomatic CAD in patients with ischemic stroke. © RSNA, 2013
Source: Radiology - August 22, 2013 Category: Radiology Authors: Ahn, S. S., Nam, H. S., Heo, J. H., Kim, Y. D., Lee, S.-K., Han, K. H., Choi, B. W., Kim, E. Y. Tags: Neuroradiology, Vascular Imaging Source Type: research