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Total 1776 results found since Jan 2013.

An Association Study of CASQ1 Gene Polymorphisms and Heat Stroke
Publication date: June 2014 Source:Genomics, Proteomics & Bioinformatics, Volume 12, Issue 3 Author(s): Ying Li , Yu Wang , Lin Ma Although molecular mechanisms of heat stroke under physiological and pathological conditions have not yet been elucidated, a novel disease-associated gene encoding a calcium-binding protein, calsequestrin-1 (CASQ1), was suggested relevant based on results from a transgenic murine model. Here, we show the association between single nucleotide polymorphisms (SNPs) of CASQ1 and physiological parameters for heat stroke from a study involving 150 patients. Pooled DNA from heat stroke patie...
Source: Genomics, Proteomics and Bioinformatics - November 1, 2014 Category: Bioinformatics Source Type: research

Changes in differential gene expression during a fatal stroke
We present a young woman (with an identical twin sister) who arrived at the Emergency Department (ED) within 1hour of her initial stroke symptoms. Previous microarray studies have demonstrated differential expression of multiple genes between stroke patients and healthy controls. However, for many of these studies there is a significant delay between the initial symptoms and collection of blood samples, potentially leaving the important early activators/regulators of the inflammatory response unrecognised. Blood samples were collected from the patient for an analysis of differential gene expression over time during the evo...
Source: Journal of Clinical Neuroscience - August 29, 2015 Category: Neuroscience Source Type: research

Dietary factors associated with stroke: a literature review.
CONCLUSIONS: The intake nuts, fruits and vegetables, fish, total protein, low-fat dairy, calcium and high adherence to Mediterranean and DASH diet could to have protective effects on stroke. While the Western diet and high consumption of red meat and processed meat, salt could to be a risk factor. Further investigation in relation to consumption of legumes, eggs, whole milk, rice, potatoes and soft drink is also necessary. PMID: 27569567 [PubMed - in process]
Source: Revista de Neurologia - August 31, 2016 Category: Neurology Authors: Lopez-Romero L, Silva-Sieger F, Gamboa-Delgado E Tags: Rev Neurol Source Type: research

Efficacy of Calcium Channel Blockers Versus Other Classes of Antihypertensive Medication in the Treatment of Hypertensive Patients With Previous Stroke and/or Coronary Artery Disease: A Systematic Review and Meta-Analysis
Hypertensive patients, such as those with established coronary artery disease (CAD) or those who have suffered a stroke, are at increased risk of morbidity and mortality. This systematic literature review and meta-analysis assesses the long-term effects of calcium channel blockers (CCBs) compared with other classes of antihypertensive medications on major cardiovascular (CV) outcomes in these high-risk subgroups of hypertensive patients. Randomized, active controlled parallel group trials were included if they compared CCBs with α-blockers, β-blockers, angiotensin II receptor blockers, angiotensin-converting enzyme inhib...
Source: American Journal of Therapeutics - January 1, 2017 Category: Drugs & Pharmacology Tags: Original Articles Source Type: research

Memantine Attenuates Cell Apoptosis by Suppressing the Calpain-Caspase-3 Pathway in an Experimental Model of Ischemic Stroke.
Abstract Ischemic stroke, the second leading cause of death worldwide, leads to excessive glutamate release, over-activation of N-methyl-D-aspartate receptor (NMDAR), and massive influx of calcium (Ca(2+)), which may activate calpain and caspase-3, resulting in cellular damage and death. Memantine is an uncompetitive NMDAR antagonist with low-affinity/fast off-rate. We investigated the potential mechanisms through which memantine protects against ischemic stroke in vitro and in vivo. Middle cerebral artery occlusion-reperfusion (MCAO) was performed to establish an experimental model of ischemic stroke. The neuropr...
Source: Experimental Cell Research - January 5, 2017 Category: Cytology Authors: Chen B, Wang G, Li W, Liu W, Lin R, Tao J, Jiang M, Chen L, Wang Y Tags: Exp Cell Res Source Type: research

Dietary calcium intake and risk of cardiovascular disease, stroke, and fracture in a population with low calcium intake.
Conclusion: In Korean women, increased dietary calcium intake was associated with a decreased CVD risk, but it did not influence the risk of stroke or fracture. PMID: 28615253 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - June 14, 2017 Category: Nutrition Authors: Kong SH, Kim JH, Hong AR, Cho NH, Shin CS Tags: Am J Clin Nutr Source Type: research

Prognostic Value of Coronary CT Angiography for Predicting Poor Cardiac Outcome in Stroke Patients without Known Cardiac Disease or Chest Pain: The Assessment of Coronary Artery Disease in Stroke Patients Study.
CONCLUSION: Assessment of stenosis degree and plaque type using CCTA provided additional prognostic value over CACS and FRS to risk stratify stroke patients without prior history of CAD better. PMID: 32691541 [PubMed - in process]
Source: Korean Journal of Radiology - July 23, 2020 Category: Radiology Tags: Korean J Radiol Source Type: research

Calcium and magnesium in drinking water and risk of myocardial infarction and stroke - a population-based cohort study
CONCLUSION: Drinking water with a high concentration of calcium and magnesium, particularly magnesium, may lower the risk of stroke in postmenopausal women.PMID:35816459 | DOI:10.1093/ajcn/nqac186
Source: The American Journal of Clinical Nutrition - July 11, 2022 Category: Nutrition Authors: Emilie Helte Melle S äve-Söderbergh Susanna C Larsson Agneta Åkesson Source Type: research

Effects of clinical and laboratory variables at admission and of in-hospital treatment with cardiovascular drugs on short term prognosis of ischemic stroke. The GIFA study
Conclusions: Our study suggests that if a patient with acute ischemic stroke has higher SBP at admission, higher total cholesterol plasma levels, a lower Charlson index and is treated with ACE-inhibitors, calcium channel blockers and antiplatelet drugs, the short term outcome is better in terms of in-hospital mortality and functional indicators such as cognitive and functional performance at discharge.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 16, 2012 Category: Nutrition Authors: A. Tuttolomondo, D. Di Raimondo, R. Di Sciacca, C. Pedone, S. La Placa, V. Arnao, A. Pinto, G. Licata Tags: Other Articles Source Type: research

Low Serum Calcium Levels Contribute to Larger Hematoma Volume in Acute Intracerebral Hemorrhage Brief Reports
Conclusions— Low admission serum calcium levels were associated with larger hematoma volume and higher National Institutes of Health Stroke Scale score among patients with acute intracerebral hemorrhage.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Inoue, Y., Miyashita, F., Toyoda, K., Minematsu, K. Tags: Acute Cerebral Hemorrhage Brief Reports Source Type: research

Pharmacological Management of Central Post-Stroke Pain: A Practical Guide
Abstract Pain is one of the most troublesome sequelae of stroke. Some of this post-stroke pain is caused by the brain lesion itself; this is called central post-stroke pain (CPSP). Although the prevalence of CPSP is low (1–8 %), persistent, often treatment-resistant, painful sensations are a major problem for stroke patients. The pathogenesis of CPSP remains unknown, but suggested underlying causes include hyperexcitation in the damaged sensory pathways, damage to the central inhibitory pathways, or a combination of the two. For pharmacological treatment, amitriptyline, an adrenergic antidepressant, is current...
Source: CNS Drugs - September 1, 2014 Category: Neurology Source Type: research

Middle Cerebral Artery Calcification: Association With Ischemic Stroke
This study retrospectively included 354 subjects with ischemic stroke in the MCA territory and 1518 control subjects who underwent computed tomography (CT) of the brain. We recorded major known risk factors for ischemic stroke, including age, gender, hypertension, diabetes mellitus, smoking, hyperlipidemia, and obesity, along with the MCA calcium burden, measured with the Agatston calcium scoring method. Univariate and modified logistic regression analyses were performed to examine the association between the MCA calcification and ischemic stroke. The univariate analyses showed significant associations of ischemic stroke w...
Source: Medicine - December 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research