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Nutrition: Calcium

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Total 1776 results found since Jan 2013.

Neuroprotective Action of Human Wharton's Jelly-Derived Mesenchymal Stromal Cell Transplants in a Rodent Model of Stroke.
Abstract Wharton's jelly-derived mesenchymal stromal cells (WJ-MSCs) have distinct immunomodulatory and protective effects against kidney, liver, or heart injury. Limited studies have shown that WJ-MSCs attenuates oxygen-glucose deprivation-mediated inflammation in hippocampal slices. The neuroprotective effect of intracerebral WJ-MSC transplantation against stroke has not been well characterized. The purpose of this study was to examine the neuroprotective effect of human WJ-MSC (hWJ-MSC) transplants in an animal model of stroke. Adult male Sprague-Dawley rats were anesthetized and placed in a stereotaxic frame. ...
Source: Cell Transplantation - October 4, 2018 Category: Cytology Authors: Wu KJ, Yu SJ, Chiang CW, Lee YW, Yen BL, Tseng PC, Hsu CS, Kuo LW, Wang Y Tags: Cell Transplant Source Type: research

Wnt-3a alleviates neuroinflammation after ischemic stroke by modulating the responses of microglia/macrophages and astrocytes.
Abstract Neuroinflammation crucially influences functional recovery after ischemic stroke. Wnt-3a, a novel Wnt protein that specifically promotes Wnt/β-catenin signaling pathway, has been shown to regulate apoptosis and cell proliferation, but how it affects ischemic stroke-induced toxic brain inflammation remains unknown. Using a transient middle cerebral artery occlusion (tMCAO) mouse model in this study, we found that intranasal Wnt-3a-treated tMCAO mice had apparently reduced infarct volume and decreased brain water content after being allowed to recover for 72 h, as well as better neurologic outcomes on da...
Source: International Immunopharmacology - July 15, 2019 Category: Allergy & Immunology Authors: Zhang D, Lu Z, Man J, Cui K, Fu X, Yu L, Gao Y, Liao L, Xiao Q, Guo R, Zhang Y, Zhang Z, Liu X, Lu H, Wang J Tags: Int Immunopharmacol Source Type: research

Relationship Between Sleep Apnea and Coronary Artery Calcium in Patients With Ischemic Stroke
Conclusion: Our findings indicate a relationship between coronary atherosclerotic burden measured by the CAC score and the severity of sleep apnea. Performing polysomnography could be useful for investigating the severity of hidden coronary artery disease among these patients.
Source: Frontiers in Neurology - July 30, 2019 Category: Neurology Source Type: research

Continuous theta burst stimulation provides neuroprotection by accelerating local cerebral blood flow and inhibiting inflammation in a mouse model of acute ischemic stroke.
Abstract Acute ischemic stroke is a leading cause of disability with limited therapeutic options. Continuous theta burst stimulation (cTBS) has recently been shown to be a promising noninvasive therapeutic strategy for neuroprotection in ischemic stroke patients. Here, we investigated the protective effects of cTBS following acute infarction using a photothrombotic stroke (PTS) model in the right posterior parietal cortex (PPC) of C57BL/6 mice. Treatment with cTBS resulted in a reduction in the volume of the infarct region and significantly increased vascular diameter and blood flow velocity in peri-infarct region...
Source: Brain Research - October 2, 2019 Category: Neurology Authors: Wu C, Li MN, Feng YW, He XF, Li WQ, Liang FY, Li X, Li G, Pei Z, Lan Y, Xu GQ Tags: Brain Res Source Type: research

Role of injection laryngoplasty in preventing post-stroke aspiration pneumonia, case series report
Conclusion: Injection laryngoplasty proved to be both successful and safe in improving glottic closure with immediate results in those who had failed to show a positive response after long-term swallowing rehabilitation. The positive and dramatic clinical outcomes were observed through changes in the coughing force. Our case series support the use of injection larygnoplasty as a powerful adjunctive treatment method to prevent aspiration pneumonia in post-stroke patients with vocal fold insufficiency. Pre- and post-injection peak cough flow changes may reflect improvement in glottic closure and indicate the safety of swal...
Source: Medicine - February 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

p5 Peptide-Loaded Human Adipose-Derived Mesenchymal Stem Cells Promote Neurological Recovery After Focal Cerebral Ischemia in a Rat Model
In conclusion, administration of hADMSC-loaded p5 peptide to post-stroke rats created conditions that supported survival of drug-loaded hADMSCs after cerebral ischemia, suggesting its therapeutic potential in patients with stroke.
Source: Translational Stroke Research - May 5, 2020 Category: Neurology Source Type: research

Association between the high risk for obstructive sleep apnea and intracranial carotid artery calcification in patients with acute ischemic stroke
ConclusionsThis study showed that the presence of calcium in symptomatic intracranial ICA was related to high risk for OSA in patients with acute ischemic stroke.
Source: Sleep and Breathing - June 18, 2020 Category: Respiratory Medicine Source Type: research

Improvement of a novel proposal for antioxidant treatment against brain damage occurring in ischemic stroke patients.
Abstract The underlying mechanism of cerebral injury occurring in patients with acute ischemic stroke involves a key pathophysiological role of oxidative stress. Thus, reactive oxygen species are related to the development of brain edema, calcium overload, mitochondrial dysfunction, excitotoxicity, iron release and inflammation. Nevertheless, although experimental studies have tested the use of antioxidants as an adjuvant therapy in this setting, clinical data and randomized trials are still lacking. Current approved pharmacological therapy is aimed at reperfusion strategies; however, the therapeutic window is lim...
Source: CNS and Neurological Disorders Drug Targets - September 9, 2020 Category: Drugs & Pharmacology Authors: Orellana-Urzúa S, Claps G, Rodrigo R Tags: CNS Neurol Disord Drug Targets Source Type: research

Iptakalim improves cerebral microcirculation in mice after ischemic stroke by inhibiting pericyte contraction
In this study we investigated the impacts of iptakalim on pericytes contraction in stroke. Mice were subjected to cerebral artery occlusion (MCAO), then administered iptakalim (10 mg/kg, ip). We showed that iptakalim administration significantly promoted recovery of cerebral blood flow after cerebral ischemia and reperfusion. Furthermore, we found that iptakalim significantly inhibited pericytes contraction, decreased the number of obstructed capillaries, and improved cerebral microcirculation. Using a collagen gel contraction assay, we demonstrated that cultured pericytes subjected to oxygen-glucose deprivation (OGD) cons...
Source: Acta Pharmacologica Sinica - October 26, 2021 Category: Drugs & Pharmacology Authors: Ruo-Bing Guo Yin-Feng Dong Zhi Yin Zhen-Yu Cai Jin Yang Juan Ji Yu-Qin Sun Xin-Xin Huang Teng-Fei Xue Hong Cheng Xi-Qiao Zhou Xiu-Lan Sun Source Type: research