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Total 1776 results found since Jan 2013.

Long-Term Anti-Hypertensive Therapy and Stroke Prevention: A Meta-Analysis
Conclusion Among the antihypertensive classes, CCBs were most effective in reducing the long-term incidence of stroke, whereas β-blockers were associated with significantly increased risk.
Source: American Journal of Cardiovascular Drugs - June 9, 2015 Category: Cardiology Source Type: research

Senicapoc: Repurposing a Drug to Target Microglia KCa3.1 in Stroke.
Abstract Stroke is the leading cause of serious long-term disability and the fifth leading cause of death in the United States. Treatment options for stroke are few in number and limited in efficacy. Neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. Interfering with the inflammation cascade after stroke holds the promise to modulate stroke outcome. The calcium activated potassium channel KCa3.1 is expressed selectively in the injured CNS by microglia. KCa3.1 function has been implicated in pro-inflammatory activation of microglia and th...
Source: Neurochemical Research - March 31, 2017 Category: Neuroscience Authors: Staal RG, Weinstein JR, Nattini M, Cajina M, Chandresana G, Möller T Tags: Neurochem Res Source Type: research

Gemst: a taylor-made combination that reverts neuroanatomical changes in stroke
In a single transient middle cerebral artery occlusion model of stroke and using immunohistochemical techniques, the effects of a new therapeutic approach named Gemst (a member of the Poly-L-Lysine innovative therapies) have been studied in the rat brain. The expression of inflammatory (CD45, CD11b), oxidative (NO-tryptophan, NO2-tyrosine) and indoleamine 2, 3-dioxygenase pathway (kynurenic acid, 3-hydroxy anthranilic acid) markers has been evaluated in early and late phases of stroke. For this purpose, we have developed eight highly specific monoclonal antibodies directed against some of these markers. In the early phase ...
Source: European Journal of Histochemistry - May 3, 2017 Category: Biomedical Science Source Type: research

Systems Pharmacology Dissection of the Anti-Stroke Mechanism for the Chinese Traditional Medicine Xing-Nao-Jing
In this study, a systems pharmacology strategy based on pharmacokinetic and pharmacodynamics data was applied to analyze the pharmacological effect of XNJ on stroke. Sixteen active compounds were filtered from XNJ through Drug-likeness (DL) and Brain-blood-barrier (BBB) evaluations. Ninety-four potential targets of these active components were identified by SysDT and SEA. Biological process and pathway enrichment analyses of these targets demonstrated that XNJ exerted anti-stroke effects by biological processes and pathways, such as the response to oxidative stress, regulation of blood pressure, calcium signaling pathway, ...
Source: Journal of Pharmacological Sciences - December 20, 2017 Category: Drugs & Pharmacology Source Type: research

Serum magnesium but not calcium was associated with hemorrhagic transformation in stroke overall and stroke subtypes: a case-control study in China
AbstractAssociation between serum calcium and magnesium versus hemorrhagic transformation (HT) remains to be identified. A total of 1212 non-thrombolysis patients with serum calcium and magnesium collected within 24  h from stroke onset were enrolled. Backward stepwise multivariate logistic regression analysis was conducted to investigate association between calcium and magnesium versus HT. Calcium and magnesium were entered into logistic regression analysis in two models, separately: model 1, as continuous va riable (per 1-mmol/L increase), and model 2, as four-categorized variable (being collapsed into quartiles). HT oc...
Source: Neurological Sciences - July 19, 2018 Category: Neurology Source Type: research

Positive effects of α-asarone on transplanted neural progenitor cells in a murine model of ischemic stroke
Conclusionα-asarone may promote NPC proliferation and differentiation into neuron-lineage cells by activating β-catenin, cyclin D1, and ERK. Moreover, α-asarone treatment facilitated neurofunctional recovery after NPC transplantation in a murine model of ischemic stroke. Therefore, α-asarone is a potential adjunct treatment to NPC therapy for functional restoration after brain injuries such as ischemic stroke.Graphical abstract
Source: Phytomedicine - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Stroke Risk in Atrial Fibrillation: Beyond the CHA 2 DS 2 -VASc Score
AbstractPurpose of ReviewStroke prevention is the cornerstone of atrial fibrillation (AF) management and the anticoagulation decision is currently based on CHA2DS2-VASc risk score. We discuss several novel risk factors besides those included in CHA2DS2-VASc score and alternative models for stroke prediction.Recent FindingsSeveral clinical markers including obstructive sleep apnea and renal failure, laboratory markers like brain natriuretic peptide, imaging criteria including left atrial appendage morphology, spontaneous echo contrast, and coronary artery calcium score may predict stroke in AF patients. Addition of African ...
Source: Current Cardiology Reports - July 26, 2019 Category: Cardiology Source Type: research

Investigation of Computed-Tomography Based Predictors of Acute Stroke Related to Transcatheter Aortic Valve Replacement: Aortic Wall Plaque Thickness Might be a Predictive Parameter of Stroke.
CONCLUSION: Aortic wall plaque thickness measured by contrast-enhanced CT might be a predictive parameter of strokes that occur within 48 hours after TAVR. PMID: 32005786 [PubMed - in process]
Source: The Journal of Invasive Cardiology - February 3, 2020 Category: Cardiology Tags: J Invasive Cardiol Source Type: research

Calcium/Calmodulin –Dependent Protein Kinase II in Cerebrovascular Diseases
AbstractCerebrovascular disease is the most common life-threatening and debilitating condition that often leads to stroke. The multifunctional calcium/calmodulin-dependent protein kinase II (CaMKII) is a key Ca2+ sensor and an important signaling protein in a variety of biological systems within the brain, heart, and vasculature. In the brain, past stroke-related studies have been mainly focused on the role of CaMKII in ischemic stroke in neurons and established CaMKII as a major mediator of neuronal cell death induced by glutamate excitotoxicity and oxidative stress following ischemic stroke. However, with growing underst...
Source: Translational Stroke Research - March 13, 2021 Category: Neurology Source Type: research

Relevance of stromal interaction molecule 1 (STIM1) in experimental and human stroke
Pflugers Arch. 2021 Nov 10. doi: 10.1007/s00424-021-02636-w. Online ahead of print.ABSTRACTStroke represents a main cause of death and permanent disability worldwide. In the attempt to develop targeted preventive and therapeutic strategies, several efforts were performed over the last decades to identify the specific molecular abnormalities preceding cerebral ischemia and neuronal death. In this regard, mitochondrial dysfunction, autophagy, and intracellular calcium homeostasis appear important contributors to stroke development, as underscored by recent pre-clinical evidence. Intracellular calcium (Ca2+) homeostasis is re...
Source: Pflugers Archiv : European Journal of Physiology - November 10, 2021 Category: Physiology Authors: Rosita Stanzione Maurizio Forte Maria Cotugno Franca Bianchi Simona Marchitti Speranza Rubattu Source Type: research

Association of DNA Methylation Patterns in 7 Novel Genes With Ischemic Stroke in the Northern Chinese Population
Conclusion: Our results demonstrate that DNA methylation plays a crucial part in ischemic stroke. The methylation of these 7 genes may be potential diagnostic biomarker for ischemic stroke.PMID:35480311 | PMC:PMC9035884 | DOI:10.3389/fgene.2022.844141
Source: Atherosclerosis - April 28, 2022 Category: Cardiology Authors: Hongwei Sun Jia Xu Bifeng Hu Yue Liu Yun Zhai Yanyan Sun Hongwei Sun Fang Li Jiamin Wang Anqi Feng Ying Tang Jingbo Zhao Source Type: research

Vitamin D supplementation and risk of stroke: A meta-analysis of randomized controlled trials
ConclusionOur study revealed that additional vitamin D supplementation did not reduce the risk of stroke. Therefore, additional RCTs of similar design should not be encouraged to assess any association between vitamin D supplementation and reduced stroke risk.
Source: Frontiers in Neurology - August 18, 2022 Category: Neurology Source Type: research

Calcium and magnesium in drinking water and risk of myocardial infarction and stroke —a population-based cohort study
ConclusionsDrinking water with a high concentration of calcium and magnesium, particularly magnesium, may lower the risk of stroke in postmenopausal women.
Source: American Journal of Clinical Nutrition - July 11, 2022 Category: Nutrition Source Type: research