Non-ionotropic voltage-gated calcium channel signaling
Channels (Austin). 2024 Dec;18(1):2341077. doi: 10.1080/19336950.2024.2341077. Epub 2024 Apr 11.ABSTRACTVoltage-gated calcium channels (VGCCs) are the major conduits for calcium ions (Ca2+) within excitable cells. Recent studies have highlighted the non-ionotropic functionality of VGCCs, revealing their capacity to activate intracellular pathways independently of ion flow. This non-ionotropic signaling mode plays a pivotal role in excitation-coupling processes, including gene transcription through excitation-transcription (ET), synaptic transmission via excitation-secretion (ES), and cardiac contraction through excitation-...
Source: Channels - April 11, 2024 Category: Molecular Biology Authors: Michael Trus Daphne Atlas Source Type: research
Non-ionotropic voltage-gated calcium channel signaling
Channels (Austin). 2024 Dec;18(1):2341077. doi: 10.1080/19336950.2024.2341077. Epub 2024 Apr 11.ABSTRACTVoltage-gated calcium channels (VGCCs) are the major conduits for calcium ions (Ca2+) within excitable cells. Recent studies have highlighted the non-ionotropic functionality of VGCCs, revealing their capacity to activate intracellular pathways independently of ion flow. This non-ionotropic signaling mode plays a pivotal role in excitation-coupling processes, including gene transcription through excitation-transcription (ET), synaptic transmission via excitation-secretion (ES), and cardiac contraction through excitation-...
Source: Channels - April 11, 2024 Category: Molecular Biology Authors: Michael Trus Daphne Atlas Source Type: research
Novel protocol for multiple-dose oral administration of the L-type Ca < sup > 2+ < /sup > channel blocker isradipine in mice: A dose-finding pharmacokinetic study
Channels (Austin). 2024 Dec;18(1):2335469. doi: 10.1080/19336950.2024.2335469. Epub 2024 Apr 2.ABSTRACTStudies in genetically modified animals and human genetics have recently provided new insight into the role of voltage-gated L-type Ca2+ channels in human disease. Therefore, the inhibition of L-type Ca2+ channels in vivo in wildtype and mutant mice by potent dihydropyridine (DHP) Ca2+ channel blockers serves as an important pharmacological tool. These drugs have a short plasma half-life in humans and especially in rodents and show high first-pass metabolism upon oral application. In the vast majority of in vivo studies, ...
Source: Channels - April 2, 2024 Category: Molecular Biology Authors: Tamara Theiner Nadine J Ortner Herbert Oberacher Gospava Stojanovic Petronel Tuluc J örg Striessnig Source Type: research
Novel protocol for multiple-dose oral administration of the L-type Ca < sup > 2+ < /sup > channel blocker isradipine in mice: A dose-finding pharmacokinetic study
Channels (Austin). 2024 Dec;18(1):2335469. doi: 10.1080/19336950.2024.2335469. Epub 2024 Apr 2.ABSTRACTStudies in genetically modified animals and human genetics have recently provided new insight into the role of voltage-gated L-type Ca2+ channels in human disease. Therefore, the inhibition of L-type Ca2+ channels in vivo in wildtype and mutant mice by potent dihydropyridine (DHP) Ca2+ channel blockers serves as an important pharmacological tool. These drugs have a short plasma half-life in humans and especially in rodents and show high first-pass metabolism upon oral application. In the vast majority of in vivo studies, ...
Source: Channels - April 2, 2024 Category: Molecular Biology Authors: Tamara Theiner Nadine J Ortner Herbert Oberacher Gospava Stojanovic Petronel Tuluc J örg Striessnig Source Type: research
Ion channel-mediated mitochondrial volume regulation and its relationship with mitochondrial dynamics
Channels (Austin). 2024 Dec;18(1):2335467. doi: 10.1080/19336950.2024.2335467. Epub 2024 Mar 28.ABSTRACTThe mitochondrion, one of the important cellular organelles, has the major function of generating adenosine triphosphate and plays an important role in maintaining cellular homeostasis, governing signal transduction, regulating membrane potential, controlling programmed cell death and modulating cell proliferation. The dynamic balance of mitochondrial volume is an important factor required for maintaining the structural integrity of the organelle and exerting corresponding functions. Changes in the mitochondrial volume a...
Source: Channels - March 28, 2024 Category: Molecular Biology Authors: Yujia Zhuang Wenting Jiang Zhe Zhao Wencui Li Zhiqin Deng Jianquan Liu Source Type: research
