Prognostic factors in tumefactive demyelinating lesions: A retrospective study
Demyelinating lesions occasionally present as mass-like lesions on imaging, raising concern for malignancy. The disease course of such tumefactive demyelinating lesions (TDLs) is still being defined. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 26, 2021 Category: Neurology Authors: R. Skipper Plowman, Hemant Varma Source Type: research

Expanding the phenotype of AFG3L2 mutations: Late-onset autosomal recessive spinocerebellar ataxia
The AFG3L2 gene encodes AFG3-like protein 2, which is a subunit of human mitochondrial ATPases associated with various cellular protease activities (m-AAA). The clinical spectrum of AFG3L2 mutations is broad. Dominant AFG3L2 mutations can cause autosomal dominant spinocerebellar ataxia type 28 (SCA28), whereas biallelic AFG3L2 mutations may lead to spastic ataxia 5 (SPAX5). However, the role of AFG3L2 mutations in autosomal recessive spinocerebellar ataxia (SCAR) remains elusive. The aim of this study is to delineate the clinical features and spectrum of AFG3L2 mutations in a Taiwanese cohort with cerebellar ataxia. (Sourc...
Source: Journal of the Neurological Sciences - July 26, 2021 Category: Neurology Authors: Han-Lin Chiang, Jong-Ling Fuh, Yu-Shuen Tsai, Bing-Wen Soong, Yi-Chu Liao, Yi-Chung Lee Source Type: research

Carotid artery angioplasty versus stenting for management of acute tandem occlusions
In this study, we aimed to evaluate the safety outcomes of CAS and carotid artery angioplasty (CAA) in patients with acute tandem occlusions.MethodsIn this retrospective cohort study, data were obtained from the Nationwide Readmissions Database 2016 –2017. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 25, 2021 Category: Neurology Authors: Aayushi Garg, Mudassir Farooqui, Cynthia B. Zevallos, Darko Quispe-Orozco, Alan Mendez-Ruiz, Osama Zaidat, Santiago Ortega-Gutierrez Source Type: research

Abnormal sweating and “skin flushing” as possible predictive factor for treatment related fluctuations in Guillain-Barré syndrome: a case series and a review of the literature
Treatment related fluctuations (TRFs) in Guillain-Barr é Syndrome (GBS) are described as one or more episodes of deterioration manifesting within two months after disease onset and following an initial improvement or stabilisation after treatment. They may be encountered in 8% to 16% of patients, but currently predictive factors of TRF occurrence and s everity are poorly known. To this end, we evaluated the frequency and clinical features of TRFs in a cohort of GBS patients admitted to the Neurological unit of Sant'Andrea Hospital (La Spezia, Italy) from January 1st, 2003 to December 31st, 2017. (Source: Journal of ...
Source: Journal of the Neurological Sciences - July 24, 2021 Category: Neurology Authors: Chiara Demichelis, Stefano Grisanti, Federico Massa, Carlo Serrati, Alessandro Beronio, Antonio Mannironi, Emanuela Mobilia, Chiara Briani, Angelo Schenone, Luana Benedetti Source Type: research

Adjuvant radiotherapy for atypical meningiomas is associated with improved progression free survival
To assess the progression-free survival benefits of adjuvant radiotherapy (ART) following surgical resection compared to surgery alone in high-grade meningioma patients. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 24, 2021 Category: Neurology Authors: Ansley Unterberger, Edwin Ng, Anjali Pradhan, Aditya Kondajji, Daniel Kulinich, Courtney Duong, Isaac Yang Source Type: research

An implantable device to treat multiple sclerosis: A discrete choice experiment on patient preferences in three European countries
This study determined MS patient preferences for three modes of first-line treatment administration (implant, pills, injectables), and trade-offs regarding treatment characteristics. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 23, 2021 Category: Neurology Authors: L.A. Visser, S.P.I. Huls, C.A. Uyl-de Groot, E.W. de Bekker-Grob, W.K. Redekop Source Type: research

Lesion topography of posterior cerebral artery infarcts
This study analyzed the topography of acute ischemic stroke in the posterior cerebral artery (PCA) territory. We studied 84 patients with unilateral ischemic PCA stroke. Patients were classified according to lesion levels as cortico-subcortical (superficial), combined (cortical and mesodiencephalic) or isolated thalamic. To receive a lesion map, data from acute MR and CT imaging were normalized and labelled automatically by mapping to stereotaxic anatomical atlases. Cortical lesions accounted for 41.7%, combined for 36.9%, and isolated thalamic lesions for 21.4%. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 23, 2021 Category: Neurology Authors: T. Benke, F. Dazinger, R. Pechlaner, K. Willeit, J. Clausen, M. Knoflach Source Type: research

Confirmation of early non-bulbar onset of amyotrophic lateral sclerosis in Spanish league soccer players.
This study aims to characterise the phenotype of seven Spanish retired professional and semi-professional soccer players. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 23, 2021 Category: Neurology Authors: Josep Gamez, Francesc Carmona Source Type: research

Evaluation and categorisation of individual patients based on white matter profiles: Single-patient diffusion data interpretation in neurodegeneration
The majority of radiology studies in neurodegenerative conditions infer group-level imaging traits from group comparisons. While this strategy is helpful to define phenotype-specific imaging signatures for academic use, the meaningful interpretation of single scans from individual subjects is more important in everyday clinical practice. Accordingly, we present a computational method to evaluate individual subject diffusion tensor data to highlight white matter integrity alterations. Fifty white matter (WM) tracts were quantitatively rated in 132 ALS patients separately with respect to demographically-matched normative val...
Source: Journal of the Neurological Sciences - July 21, 2021 Category: Neurology Authors: Marlene Tahedl, Aizuri Murad, Jasmin Lope, Orla Hardiman, Peter Bede Source Type: research

Reply to: Letter to the Editor – N. Mitchell; Covid-19: Involvement of the nervous system. Identifying neurological predictors defining the course of the disease
We read with great interest the comments in the letter by N. Mitchell regarding the prediction of neurological symptoms of Covid-19 by using the age of the study participants. Indeed, we are grateful for the valuable insights into a still scantly explored aspect of the disease. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 20, 2021 Category: Neurology Authors: Udo Zifko Tags: Letter to the Editor Source Type: research

Vocal cord paresis on CTA - A novel tool for the diagnosis of lateral medullary syndrome
Diagnosis of lateral medullary syndrome (LMS) is often delayed due to elusive clinical presentations and frequently non-revealing neuroimaging tests. We aimed to investigate the use of ipsilateral vocal cord paresis (VCP) identified on neck computed tomography angiography (CTA) as an early diagnostic sign for LMS. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 16, 2021 Category: Neurology Authors: Shlomi Peretz, Shira Rosenblat, Michal Zuckerman, Edna Inbar, Hagit Shoffel-Havakuk, Rani Barnea, Israel Steiner, Tzippy Shochat, Eitan Auriel, Dror Suhami Source Type: research

Reply to: Covid-19: Involvement of the nervous system. Identifying neurological predictors defining the course of the disease.
Dear Editor, (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 16, 2021 Category: Neurology Authors: Nathan Mitchell Tags: Letter to the Editor Source Type: research

Clinical profile and outcome of non-COVID strokes during pandemic and the pre pandemic period: COVID-Stroke Study Group (CSSG) India
As the health systems around the world struggled to meet the challenges of COVID-19 pandemic, care of many non-COVID emergencies was affected. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 15, 2021 Category: Neurology Authors: Rohit Bhatia, P.N. Sylaja, M.V. Padma Srivastava, Snigdha Komakula, Thomas Iype, Rajsrinivas Parthasarathy, Dheeraj Khurana, Vibhor Pardesani, Vijaya Pamidimukkala, S. Kumaravelu, Jeyaraj Pandian, Suman Kushwaha, Debashish Chowdhury, Salil Gupta, Srijithe Source Type: research

IV tPA given in the golden hour for emergent large vessel occlusion stroke improves recanalization rates and clinical outcomes
Early thrombolysis for acute ischemic stroke (AIS) due to emergent large vessel occlusion (ELVO) is associated with better clinical outcome. This is thought to be due to greater tissue salvage with earlier recanalization. We explored whether ultra-early administration of intravenous tissue plasminogen activator (IV tPA) within 60  min (Golden Hour) of symptom onset for AIS due to ELVO is associated with a higher rate of recanalization. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 14, 2021 Category: Neurology Authors: Rodica Di Lorenzo, Maher Saqqur, Andrew Blake Buletko, Lacy Sam Handshoe, Bhageeradh Mulpur, Julian Hardman, Megan Donohue, Dolora Wisco, Ken Uchino, M. Shazam Hussain Source Type: research

Changes in autonomic tone during delirium in acute stroke patients assessed by pupillometry and skin conductance
Delirium is a common complication in acute ischemic stroke, possibly caused by alterations in the regulation of the sympathetic autonomic nervous system. We investigated whether such an association could be demonstrated with two easy-to-use measurement techniques: Measurement of palmar skin conductance level (SCL) and pupillometry measuring the dilation velocity in the pupillary light reflex (PLRdil.vel.).The cohort study included 64 patients admitted with acute ischemic stroke. During the study period (median 4.1  days, interquartile range 2.1 days) patients were assessed for delirium once daily as well as with measur...
Source: Journal of the Neurological Sciences - July 14, 2021 Category: Neurology Authors: Jannik Stokholm, Lars Kristian Hebsgaard Birkmose, Abd Al Bari Omar Ahmed, Claudio Csillag, Troels Wesenberg Kj ær, Thomas Christensen Source Type: research

The evaluation of the swallow tail sign in patients with parkinsonism and gait disorders
Swallow tail sign (STS), which represents nigrosome-1 in the substantia nigra on 3 Tesla (T) susceptibility-weighted imaging (SWI), has attracted attention as a promising magnetic resonance imaging (MRI) biomarker for idiopathic Parkinson's disease (iPD). Some reports have shown high sensitivity and specificity —both above 94%—for distinguishing iPD from healthy controls. However, abnormal STS has been observed in many neurodegenerative parkinsonisms and even in multiple sclerosis. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 14, 2021 Category: Neurology Authors: Duk Soo Kim, Glenn A. Tung, Umer Akbar, Joseph H. Friedman Tags: Clinical short communication Source Type: research

Neurology trial registrations on ClinicalTrials.gov between 2007 and 2018: A cross-sectional analysis of characteristics, early discontinuation, and results reporting
Increasing neurological disease burden and advancing treatment options require clinical trials to expand the evidence base of clinical care. We aimed to characterize neurology clinical trials registered between October 2007 and April 2018 and identify features associated with early discontinuation and results reporting. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 14, 2021 Category: Neurology Authors: Brandon E. Turner, Christopher J. Magnani, Alexander Frolov, Brannon T. Weeks, Jecca R. Steinberg, Naureen Huda, Lochan M. Shah, Leah Zuroff, Ben Jiahe Gu, Hannah Rasmussen, Jeffrey G. Edwards, Akshay V. Save, Max Shen, Mark Ren, Barry R. Bryant, Qian Ma, Source Type: research

Impaired visual search in posterior cortical atrophy vs. typical Alzheimer's disease
Posterior cortical atrophy (PCA) is a neurocognitive disorder characterized by difficulty localizing in space. Recognizing PCA is important because it is usually missed early in its course and may result from a number of neurological disorders other than Alzheimer's disease (AD). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 12, 2021 Category: Neurology Authors: Mario F. Mendez, Youssef I. Khattab, Oleg Yerstein Source Type: research

Bariatric Wernicke's encephalopathy
I agree with Velotti, Vitiello, Berardi, Milone and Musella that thiamine deficiency is an underestimated risk of bariatric surgery. It is better to prevent than to treat vitamine B1 deficiency early on. Also, the risk for thiamine deficiency is chronic after the bariatric procedures, therefore indeed chronic prophylaxis is required. One finding from our systematic research on bariatric Wernicke's Encephalopathy patients was that many patients (up to 30 –35%) do not go to follow-up meetings following a bariatric intervention, suggesting that the prophylactic treatment plans for thiamine deficiency should be discussed...
Source: Journal of the Neurological Sciences - July 11, 2021 Category: Neurology Authors: Erik Oudman Tags: Response to letter to the Editor Source Type: research

Paired cognitive flexibility task with symptom factors improves detection of sports-related concussion in high school and collegiate athletes
This study quantified the sensitivity and specificity of a computerized cognitive flexibility task isolating shifts of visuospatial attention in combination with clinical symptoms acutely ( (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 9, 2021 Category: Neurology Authors: Amanda L. McGowan, Abigail C. Bretzin, Morgan Anderson, Matthew B. Pontifex, Tracey Covassin Source Type: research

Influence of age on links between major modifiable risk factors and stroke occurrence in West Africa
BackgroundThe burden of stroke in Africa is high. Understanding how age associates with major modifiable stroke risk factors could inform tailored demographic stroke prevention strategies.PurposeTo quantify the magnitude and direction of the effect sizes of key modifiable stroke risk factors according to three age groups: 65 years (elderly) in West Africa.MethodsThis was a case-control study involving 15 sites in Ghana and Nigeria. Cases included adults aged ≥18 years with CT/MRI scan-typed stroke. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 8, 2021 Category: Neurology Authors: Fred S. Sarfo, Onoja Akpa, Bruce Ovbiagele, Albert Akpalu, Kolawole Wahab, Morenikeji Komolafe, Reginald Obiako, Lukman Owolabi, Godwin O. Osaigbovo, Carolyn Jenkins, Godwin Ogbole, Adekunle Fakunle, Hemant K. Tiwari, Oyedunni Arulogun, Donna K. Arnett, O Source Type: research

The development of a diversity, equity, and inclusion committee in a neurology department and residency program
Diversity, Equity, and Inclusion (DEI) initiatives have been described in different academic and graduate medical education settings, but not specifically in neurology. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 8, 2021 Category: Neurology Authors: Jasmin M. Harpe, Joseph E. Safdieh, Susan Broner, Greta Strong, Matthew S. Robbins Tags: Clinical short communication Source Type: research

Bal ó's concentric sclerosis – A rare entity within the spectrum of demyelinating diseases
Bal ó's concentric sclerosis (BCS) is a rare, inflammatory demyelinating disease of the central nervous system (CNS). Historically, BCS was thought to be uniformly fatal and diagnosis was based on postmortem findings. With advances in modern neuroimaging, BCS is currently defined by the presence of con centric layered patterns composed of alternating rings of varying intensity. They are best appreciated on gadolinium-enhanced T1-weighted sequences and predominantly occur in the supratentorial cerebral white matter with sparing of cortical U-fibers. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 6, 2021 Category: Neurology Authors: Jim Shenchu Xie, Trishal Jeeva-Patel, Edward Margolin Tags: Review Article Source Type: research

Screening indexes for cardiovascular autonomic failure in Parkinson's disease
Autonomic failure (AF) is a common source of orthostatic hypotension (OH) in Parkinson's disease (PD). The diagnosis of AF is difficult on clinical grounds alone. We used autonomic testing and 24-h BP monitoring (ABPM) in 122 PD patients to evaluate the diagnostic accuracy of AF by (1) the reduced heart rate increase to fall in blood pressure (BP) ratio ( ΔHR/ΔSBP), (2) reverse dipping (RD), and (3) increased diurnal systolic BP standard deviation (SD-SBP). Among patients with OH, ΔHR/ΔSBP yielded the best accuracy (85%), with excellent sensitivity (92%) and acceptable specificity (67%). (Source: Jo...
Source: Journal of the Neurological Sciences - July 6, 2021 Category: Neurology Authors: F. Vallelonga, G. Sobrero, M. Giudici, M. Valente, V. Milazzo, C. Di Stefano, S. Maule Tags: Clinical short communication Source Type: research

Comment on “Wernicke-Korsakoff syndrome despite no alcohol abuse: A summary of systematic reports” – A matter of bariatric patients' management
we read with great interest the review from Oudman et al. [1] reporting about Wernicke-Korsakoff syndrome (WKS) in patients with no alcohol abuse. Authors relevantly concluded that nutritional impoverishment leads to profound brain damage and that physicians sometimes underestimate the risks for nonalcoholic WKS. By this point of view, we found it is fundamental to draw attention on bariatric surgery and, particularly, on the opportunity to evaluate thiamine deficiencies after all restrictive procedures. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 5, 2021 Category: Neurology Authors: Nunzio Velotti, Antonio Vitiello, Giovanna Berardi, Marco Milone, Mario Musella Tags: Letter to the Editor Source Type: research

Protein A immunoadsorption for the treatment of refractory anti-N-methyl-d-aspartate receptor encephalitis: A single-center prospective study
The aim of this study was to evaluate the efficacy and safety of protein A immunoadsorption (IA) for anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis resistant to intravenous methylprednisolone (IVMP) and intravenous immunoglobulin (IVIG). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 5, 2021 Category: Neurology Authors: Bingjun Zhang, Dafan Yu, Qiang Zhu, Hengfang Ruan, Boguang Yu, Chunping Cui, Yu Yang, Wei Qiu Source Type: research

Increased telomere length in patients with frontotemporal dementia syndrome
Telomeres are repetitive DNA sequences of TTAGGG at the ends of chromosomes. Many studies have shown that telomere shortening is associated with aging-related diseases, such as cardiovascular diseases, hypertension, diabetes, cancer, and various neurodegenerative diseases, including Alzheimer's disease, vascular dementia, Parkinson's disease, and dementia with Lewy bodies. However, changes in telomere length (TL) in patients with frontotemporal dementia (FTD) syndrome are unclear. Accordingly, in this study, we assessed TL in blood samples from patients with FTD syndrome. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 3, 2021 Category: Neurology Authors: Eun-Joo Kim, Seong-Ho Koh, Jungsoon Ha, Duk L. Na, Sang Won Seo, Hee-Jin Kim, Kyung Won Park, Jae-Hong Lee, Jee Hoon Roh, Jay C. Kwon, Soo Jin Yoon, Na-Yeon Jung, Jee H. Jeong, Jae-Won Jang, Hee-Jin Kim, Kee Hyung Park, Seong Hye Choi, SangYun Kim, Young Tags: Clinical short communication Source Type: research

TARDBP p.I383V, a recurrent alteration in Greek FTD patients
A significant proportion of FTD (Frontotemporal Degeneration) cases can be attributed to mutations in major genes such as GRN, MAPT and C9orf72. Our previous report on a Greek FTD cohort revealed the presence of the single nucleotide polymorphism (SNP) p.I383V (rs80356740) in the TARDBP gene in three unrelated patients. Our objective was to develop a novel, fast and accurate method for the detection of this particular SNP and evaluate the assay in a larger cohort. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 3, 2021 Category: Neurology Authors: Eirini Charoniti, Vasiliki Papastefanopoulou, Chryseis Florou-Hatziyiannidou, Christos Koros, Evangelia Stanitsa, John D. Papatriantafyllou, Sokratis G. Papageorgiou, Christos Kroupis Source Type: research

Transient global amnesia and Covid-19
We read with interest the letter on “Potentials to alleviate coagulopathy and enhance microglial function of beta (β)- glucans, making them worth a clinical study for COVID-19's neurological sequalae” by Raghavan et al., recently published online in the Journal of the Neurological Sciences [1]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 2, 2021 Category: Neurology Authors: Ralph Werner, Johannes C. Woehrle Tags: Letter to the Editor Source Type: research

Ventriculopleural shunt: Review of literature and novel ways to improve ventriculopleural shunt tolerance
Cerebrospinal fluid (CSF) diversion is among the most commonneurosurgical procedures that are performed worldwide. It is estimated thatapproximately 30,000 ventriculostomies are performed annually in the United States.Ventriculoperitoneal (VP) shunt malfunction rate within the first year of initialimplantation has been reported to be as high as 11 –25%. In patients with abdominaladhesions, infections or multiple failed VP shunts, another bodily compartment shouldbe utilized as a substitute for the peritoneal cavity for distal shunt catheter placement.Ventriculopleural (VPL) shunting for hydrocephalus was first introd...
Source: Journal of the Neurological Sciences - July 2, 2021 Category: Neurology Authors: Timothy Wong, Justin Gold, Ryan Houser, Yehuda Herschman, Raja Jani, Ira Goldstein Tags: Review Article Source Type: research

Mild cognitive impairment, dementia and risk of mortality in essential tremor: A longitudinal prospective study of elders
There is evidence that the risk of mortality is increased in patients with essential tremor (ET), however, there are few longitudinal, prospective data on the predictors of mortality in ET. There is also evidence that ET is associated with cognitive impairment; yet, it is unknown whether this is associated with elevated risk of mortality. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - July 1, 2021 Category: Neurology Authors: Nikki Delgado, Daniella Iglesias Hernandez, Keith Radler, Edward D. Huey, Stephanie Cosentino, Elan Louis Source Type: research

George Kenneth York III
George K. York III, neurologist, historian of neurology, and healthcare executive died in Fiddletown California on June 14, 2021 at the age of 70 after a protracted series of medical adversities. George was a skilled clinician, world-renowned historian, creative writer, and expert in finance and audit. He was a concerned and empathetic physician who saw his clinical role primarily as a patient advocate. His accomplishments in his parallel life as an academic historian of neurology included chairmanships of the history sections of the American Academy of Neurology and World Federation of Neurology, twice winner of the AAN's...
Source: Journal of the Neurological Sciences - June 30, 2021 Category: Neurology Authors: David A. Steinberg Tags: Editorial Source Type: research

Predicting short and long-term mortality after acute ischemic stroke using EHR
In this study, we leveraged administrative data to build predictive models of short- and long-term post-stroke all-cause-mortality. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 28, 2021 Category: Neurology Authors: Vida Abedi, Venkatesh Avula, Seyed-Mostafa Razavi, Bavishi Shreya, Durgesh Chaudhary, Shima Shahjouei, Ming Wang, Christoph J. Griessenauer, Jiang Li, Ramin Zand Source Type: research

Self-reported occupational functioning in persons with relapsing-remitting multiple sclerosis: Does personality matter?
Multiple sclerosis (MS) poses a major threat to sustainable employability. Identifying conditions and factors that promote work participation is of great importance. Our objective was to explore the contribution of personality traits in explaining occupational functioning in MS. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 28, 2021 Category: Neurology Authors: K. van der Hiele, D.A.M. van Gorp, E.E.A. van Egmond, P.J. Jongen, M.F. Reneman, J.J.L. van der Klink, E.P.J. Arnoldus, E.A.C. Beenakker, J.J.J. van Eijk, S.T.F.M. Frequin, K. de Gans, G.J.D. Hengstman, E. Hoitsma, O.H.H. Gerlach, W.I.M. Verhagen, M.A.P. Source Type: research

Bevacizumab for stereotactic radiosurgery-induced radiation necrosis in patients with non-small cell lung cancer treated with immune check-point inhibitors
Bevacizumab was shown to be effective in the treatment of brain radiation necrosis (RN) attributed to the use of stereotactic radiosurgery (SRS). Data on its efficacy and safety in non-small cell lung cancer (NSCLC) patients treated with immune check-point inhibitors (ICI) is lacking. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 24, 2021 Category: Neurology Authors: Assaf Moore, Shlomit Yust-Katz, Oded Icht, Ruth Eliyahu, Noa Gordon, Aharon Yehonatan Cohen, Iris Magdalena Goldstein, Nir Peled, Tali Seigal, Alexandra Amiel, Elizabeth Dudnik Source Type: research

Is the weekend effect true in acute stroke patients at tertiary stroke center?
There is contradicting evidence on the outcome of emergency patients treated during weekends versus weekdays. We studied if outcome of ischemic stroke patients receiving intravenous thrombolysis (IVT) differs according to the treatment time. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 24, 2021 Category: Neurology Authors: Silja R äty, Nicolas Martinez-Majander, Olli Suomalainen, Gerli Sibolt, Marjaana Tiainen, Kati Valkonen, Tiina Sairanen, Nina Forss, Sami Curtze Source Type: research

An amyotrophic lateral sclerosis hot spot in the French Alps associated with genotoxic fungi
Between 1990 and 2018, 14 cases of amyotrophic lateral sclerosis (ALS) were diagnosed in residents of, and in visitors with second homes to, a mountainous hamlet in the French Alps. Systematic investigation revealed a socio-professional network that connected ALS cases. Genetic risk factors for ALS were excluded. Several known environmental factors were scrutinized and eliminated, notably lead and other chemical contaminants in soil, water or home-grown vegetation used for food, radon and electromagnetic fields. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 24, 2021 Category: Neurology Authors: E. Lagrange, J.P. Vernoux, J. Reis, V. Palmer, W. Camu, P.S. Spencer Source Type: research

The costs of care from a US claims database in patients with neuromyelitis optica spectrum disorder
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease of the central nervous system that often leads to severe disability. Patients with highly active NMOSD have approximately a 10-times higher hospital inpatient admission rate compared with patients without NMOSD. Accurate assessments of the impact of NMOSD treatments on the burdens of illness require quantitative metrics of these burdens, including costs of care. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 23, 2021 Category: Neurology Authors: Alex Exuzides, Daniel Sheinson, Paris Sidiropoulos, Shervin Gholizadeh, Fabio Magrini, Andy Surinach, Lawrence Cook, Craig S. Meyer, Michael R. Yeaman Source Type: research

Potentials to alleviate coagulopathy and enhance microglial function of beta ( β)- glucans, making them worth a clinical study for COVID-19's neurological sequalae
Widespread neurological and psychiatric sequalae of COVID-19 have been reported affecting all age groups [1] with presence of low-grade chronic inflammation and down-regulated ACE-2 levels making the individual more vulnerable for severe neurological effects of COVID-19 [2] as there will be greater disruption of the blood-brain barrier and hyper inflammation. Systemic immune inflammation index (SII) including neutrophil, platelet and lymphocyte counts serve as potential biomarkers to find an individual's risk of neurological effects of COVID-19 [2]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 22, 2021 Category: Neurology Authors: Kadalraja Raghavan, Ramesh Shankar Kandaswamy, Nobunao Ikewaki, Masaru Iwasaki, Samuel J.K. Abraham Tags: Letter to the Editor Source Type: research

Carotid webs in large vessel occlusion stroke: Clinical, radiological and thrombus histopathological findings
Carotid webs are an under-recognized embolic source in patients with cryptogenic stroke. Limited resources currently exist to assist clinicians in stroke prevention for patients with symptomatic carotid webs (SCW). We aimed at analysing the clinical, radiological and procedural features of stroke patients with SCW undergoing endovascular thrombectomy (EVT), and to describe the histopathological composition of their occlusive thrombi. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 21, 2021 Category: Neurology Authors: Aurora Semerano, Zakaria Mamadou, Jean Philippe Desilles, Candice Sabben, Marco Bacigaluppi, Michel Piotin, Mickael Mazighi, Lucas Di Meglio, Michael Obadia Tags: Clinical short communication Source Type: research

Clinical effects associated with five-year retinal nerve fiber layer thinning in multiple sclerosis
Neurodegenerative changes in multiple sclerosis (MS) are associated with long-term disability progression (DP). Optical coherence tomography (OCT) measures may be used to monitor DP. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 21, 2021 Category: Neurology Authors: Dejan Jakimovski, Robert Zivadinov, Caila B. Vaughn, Osman Ozel, Bianca Weinstock-Guttman Source Type: research

Characterization of adult patients with Guillain –Barré syndrome during the arboviral infection outbreaks in Honduras
This study describes the characteristics of GBS associated with arbovirus infections during the outbreak which occurred in Honduras from January 2016 to February 2019. This was an observational retrospective study of adult patients who were diagnosed with GBS during that time. The diagnosis of GBS was based upon the criteria first published by Asbury, et al. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 20, 2021 Category: Neurology Authors: Odalis A. S ánchez, Kendy M. Portillo, Selvin Z. Reyes-Garcia, John D. England, Marco T. Medina Source Type: research

World Brain Day 2021 campaign continue to gain the momentum; join us to stop multiple sclerosis
Despite brain disorders being the leading cause of disability and second leading cause of death, among the most costly diseases globally,the depressing reality is that resources and funds for prevention, treatment, education and research are scarce compared with other diseases. Global awareness and recognition of brain disorders as a high-priority area for disease control is urgently needed. Neurologists and neurology organisations have a major, key advocacy role in taking on this challenge. National and international collaboration to increase awareness, improved prevention and treatment of brain disorders is necessary. (S...
Source: Journal of the Neurological Sciences - June 19, 2021 Category: Neurology Authors: Tissa Wijeratne, Wolfgang Grisold, William Carroll Tags: Editorial Source Type: research

Patient-reported burden of symptoms in neuromyelitis optica: A secondary analysis on pain and quality of life
Relapses of neuromyelitis optica spectrum disorder (NMOSD) result in cumulative neurologic disabilities, are unpredictable, and are interspersed with remissions. Pain in NMOSD is often severe and intractable, with a significant impact on patient quality of life (QoL). We performed a more detailed analysis of previously published survey data on the association of pain and QoL, comparing patients who were seropositive and seronegative for antibodies against aquaporin-4 (AQP4-IgG). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 18, 2021 Category: Neurology Authors: Kazuo Fujihara, Satoshi Hattori, Ingo Kleiter, Michael Levy, Yuya Matsuda, Asako Mitsutake, Masayuki Haramura, Jacqueline Palace, Takashi Yamamura, on behalf of The Guthy-Jackson Charitable Foundation NMOSD Quality of Life Working Group Source Type: research

A minority of patients with functional seizures have abnormalities on neuroimaging
Functional seizures often are managed incorrectly as a diagnosis of exclusion. However, a significant minority of patients with functional seizures may have abnormalities on neuroimaging that typically are associated with epilepsy, leading to diagnostic confusion. We evaluated the rate of epilepsy-associated findings on MRI, FDG-PET, and CT in patients with functional seizures. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 18, 2021 Category: Neurology Authors: Wesley T. Kerr, John K. Lee, Amir H. Karimi, Hiroyuki Tatekawa, L. Brian Hickman, Michael Connerney, Siddhika S. Sreenivasan, Ishita Dubey, Corinne H. Allas, Jena M. Smith, Ivanka Savic, Daniel H.S. Silverman, Lubomir M. Hadjiiski, Nicholas J. Beimer, Wil Source Type: research

Comorbidities worsen the prognosis of generalized myasthenia gravis post-thymectomy
The effect of comorbidities on the prognosis of myasthenia gravis (MG) remains unclear. In particular, the role of other autoimmune diseases (AD) is controversial. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 18, 2021 Category: Neurology Authors: Sini M. Laakso, Chris Myllynen, Daniel Strbian, Sari Atula Source Type: research

Status epilepticus: Practice variation and adherence to treatment guideline in a large community hospital
To evaluate the treatment of status epilepticus (SE) and adherence to treatment guideline in a large Finnish community hospital. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 17, 2021 Category: Neurology Authors: Joni J. Sairanen, Anne-Mari Kantanen, Harri T. Hypp ölä, Reetta K. Kälviäinen Source Type: research

Bowel, bladder, and sudomotor symptoms in ALS patients
To describe prevalence rates of bowel, bladder, and sudomotor symptoms in patients with amyotrophic lateral sclerosis (ALS) in relation to disease onset and progression. Treatment strategies and efficacies were also assessed. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 16, 2021 Category: Neurology Authors: Verena C. Samara, Patricia Jerant, Summer Gibson, Mark Bromberg Source Type: research

Lyme neuroborreliosis-associated cerebrovascular events in the Finnish endemic area
Neuroborreliosis is a rare cause of cerebral vasculitis and stroke. The incidence of Lyme borreliosis in Finland has been increasing in the last 20  years, so we expect that Lyme neuroborreliosis–associated vasculitis can be a more common cause of stroke in the future. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 16, 2021 Category: Neurology Authors: Maria Mironova, Elisa Kortela, Satu Kurkela, Mari Kanerva, Sami Curtze Source Type: research

Mechanical thrombectomy for stroke patients anticoagulated with direct oral anticoagulants versus warfarin
BackgroundOutcomes after mechanical thrombectomy (MT) for large vessel occlusion (LVO) were compared between stroke patients anticoagulated with direct oral anticoagulants (DOACs) and those anticoagulated with warfarin. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 16, 2021 Category: Neurology Authors: Junpei Koge, Kanta Tanaka, Hiroshi Yamagami, Takeshi Yoshimoto, Kazutaka Uchida, Takeshi Morimoto, Kazunori Toyoda, Nobuyuki Sakai, Shinichi Yoshimura Source Type: research