Greater intraprocedural systolic blood pressure and blood pressure variability are associated with contrast-induced neurotoxicity after neurointerventional procedures
Contrast-induced neurotoxicity (CIN) is a rare complication of neurointerventional procedures and its understanding remains limited. We evaluated the association of CIN with systemic hemodynamics in patients undergoing neuroendovascular interventions. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 24, 2020 Category: Neurology Authors: Cynthia B. Zevallos, Biyue Dai, Sudeepta Dandapat, Darko Quispe-Orozco, Andrea Holcombe, Sameer Ansari, Mudassir Farooqui, Colin P. Derdeyn, Edgar A. Samaniego, Santiago Ortega-Gutierrez Source Type: research

A hypothesis-generating scoping review of miRs identified in both multiple sclerosis and dementia, their protein targets, and miR signaling pathways
Cognitive impairment (CI) is a frequent complication affecting people with multiple sclerosis (MS). The causes of CI in MS are not fully understood. Besides MRI measures, few other biomarkers exist to help us predict the development of CI and understand its biology. MicroRNAs (miRs) are relatively stable, non-coding RNA molecules about 22 nucleotides in length that can serve as biomarkers and possible therapeutic targets in several autoimmune and neurodegenerative diseases, including the dementias. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 22, 2020 Category: Neurology Authors: Aditi Vian Varma-Doyle, Walter J. Lukiw, Yuhai Zhao, Jesus Lovera, Deidre Devier Tags: Review Article Source Type: research

Understanding the risk of incidental findings: A qualitative study of people with cognitive symptoms
Incidental imaging findings are abnormalities of potential clinical significance discovered unintentionally that are not related to the symptoms that prompted the test [1]. Their identification frequently leads to adverse psychological and social consequences [2,3]. Knowledge of the concept of incidental findings prior to imaging may enhance patient autonomy and reduce anxiety in the event that an incidental finding is subsequently identified [4]. However, the risk of incidental findings is frequently not discussed in clinical practice. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 22, 2020 Category: Neurology Authors: Stella A. Glasmacher, Fraser S. Brown, Lucy Stirland, Tim Wilkinson, Guy Holloway, Suvankar Pal Source Type: research

The effects of Cannabis on hallucinations in Parkinson's disease patients
Cannabis use is on the rise both as medical treatment and recreational use. There is evidence that cannabis can cause hallucinations and psychosis especially with heavy and prolonged use. Parkinson's disease (PD) carries an increased risk for development of hallucinations and psychosis. It is possible that cannabis may exacerbate this risk and result in earlier and greater amounts of hallucinations and psychosis in this vulnerable population. A literature review was performed to determine the answer to that question. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 22, 2020 Category: Neurology Authors: Brian Cravanas, Karen Frei, Loma Linda Tags: Review Article Source Type: research

Analysis of academic publishing output among 1634 successful applicants in the 2011 –2018 neurosurgery residency match
Research productivity is a key criterion for applicant selection reported by residency program directors. Research volume reported on neurosurgery residency applications has risen steadily over the past decade. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 22, 2020 Category: Neurology Authors: John P. Sheppard, Carlito Lagman, Thien Nguyen, Hana Yokoi, Stacy Jeong, Peter Luong, Cheng Hao Jacky Chen, Vera Ong, Alexis French, Alyssa M. Franks, Isabelle Kwan, Mahlet Mekonnen, Edwin Ng, Audree Evans, Komal Preet, Methma Udawatta, Isaac Yang Source Type: research

Cerebrovascular complications and vasculopathy in patients with herpes simplex virus central nervous system infection
Herpes simplex viruses (HSV) are neurotropic and known to cause central nervous system (CNS) infections. We aimed to describe the clinical and imaging features of cerebrovascular complications in patients with HSV CNS infections. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 22, 2020 Category: Neurology Authors: Tracey H. Fan, Jean Khoury, Sung-Min Cho, Adarsh Bhimraj, Aaron Shoskes, Ken Uchino Tags: Clinical short communication Source Type: research

Mechanical Thrombectomy in acute ischemic stroke patients with left ventricular assist device: More information, more evidence.
To the editor, (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 21, 2020 Category: Neurology Authors: Zi-yang Sun, Xiao-yan Meng Source Type: research

The effect of head positioning on cerebral hemodynamics: Experiences in mild ischemic stroke
It is generally agreed that optimal head positioning is an important consideration in acute stroke management regime. However, there is limited literature investigating the effect of head positioning changes on cerebrovascular physiology in acute ischemic stroke (AIS). We aim to assess cerebral autoregulation (CA) and associated hemodynamic responses during gradual head positioning (GHP) changes, between AIS and controls. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 21, 2020 Category: Neurology Authors: Man Y. Lam, Victoria J. Haunton, Mintu Nath, Ronney B. Panerai, Thompson G. Robinson Source Type: research

Rituximab efficacy at different initial and maintenance doses in neuromyelitis optica spectrum disorder: Experience from a national health institute in M éxico
NMOSD is an inflammatory disorder of the central nervous system that primarily affects the optic nerves and spinal cord. Rituximab (RTX) is a monoclonal antibody directed against CD20, an epitope expressed on pre-B and mature B cells. It has of wide use in several antibody-mediated autoimmune diseases. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 21, 2020 Category: Neurology Authors: Adriana Casallas-Vanegas, Enrique Gomez-Figueroa, Adib Jorge de Sar áchaga, Indhira Zabala-Angeles, Christian García-Estrada, Jorge C. Salado-Burbano, María Clara DiazGranados-Palacio, Teresita Corona-Vázquez, José de Jesús Flores-Rivera, Verónica Source Type: research

Author response: Mechanical thrombectomy in acute ischemic stroke patients with left ventricular assist device: More information, more evidence.
We thank Sun et al. for their interest in our article on mechanical thrombectomy in patients with left ventricular assist device (LVAD) [1]. We absolutely concur with their views that further studies are necessary to confirm our findings and there is a need for elucidating the best treatment strategy in this high-risk population. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 19, 2020 Category: Neurology Authors: Takaya Kitano, Kenich Todo Source Type: research

Initial and subsequent 3-year cost after hospitalization for first acute ischemic stroke and intracerebral hemorrhage
To examine 1) the major drivers of index hospitalization and 3-year post-acute follow-up care, 2) cost for rehabilitation and homecare, and 3) indirect cost from lost productivity after acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 18, 2020 Category: Neurology Authors: Mohammed Yousufuddin, James P. Moriarty, Kandace A. Lackore, Ye Zhu, Jessica L. Peters, Taylor Doyle, Kelsey L. Jensen, Eimad M. Ahmmad, Ruaa Y. Al Ward, Hossam M. Al-Zu'bi, Umesh M. Sharma, Ashok Seshadri, Kogulavadanan Arumaithurai, Lawrence R. Keenan, Source Type: research

Western Pacific ALS-PDC: Evidence implicating cycad genotoxins
Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex is a disappearing neurodegenerative disorder of apparent environmental origin formerly hyperendemic among Chamorros of Guam-USA, Japanese residents of the Kii Peninsula, Honshu Island, Japan and Auyu-Jakai linguistic groups of Papua-Indonesia. The most plausible etiology is exposure to genotoxins in seed of neurotoxic cycad plants formerly used for food and/or medicine. Primary suspicion falls on methylazoxymethanol (MAM), the aglycone of cycasin and on the non-protein amino acid β-N-methylamino-L-alanine, both of which are metabolized to formaldehyde. (S...
Source: Journal of the Neurological Sciences - October 15, 2020 Category: Neurology Authors: Peter S. Spencer, Valerie S. Palmer, Glen E. Kisby Tags: Review Article Source Type: research

No prognostic differences between GBM-patients presenting with postoperative SMA-syndrome and GBM-patients involving cortico-spinal tract and primary motor cortex
The supplementary motor area (SMA) is involved in several aspects of motor control and its can be associated to a contralateral motor deficit and speech disorders. After the resection of low-grade gliomas, this syndrome is diffusely reported but it is rarely investigated in high-grade gliomas. SMA deficits may resolve completely or with minor sequelae within weeks. Whether this condition of transient deficit affects survival, was not previously investigated, and is not currently understood. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 15, 2020 Category: Neurology Authors: Maurizio Salvati, Daniele Armocida, Alessandro Pesce, Mauro Palmieri, Emiliano Venditti, Giancarlo D'Andrea, Alessandro Frati, Antonio Santoro Source Type: research

Cerebral venous sinus thrombosis associated with SARS-CoV-2; a multinational case series
We present a series of CVST cases with SARS-CoV-2 infection.Methods In a multinational retrospective study, we collected all cases of CVST in SARS-CoV-2 infected patients admitted to nine tertiary stroke centers from the beginning of the pandemic to June 30th, 2020. We compared the demographics, clinical and radiological characteristics, risk factors, and outcome of these patients with a control group of non-SARS-CoV-2 infected CVST patients in the same seasonal period of the years 2012 –2016 from the country where the majority of cases were recruited. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 14, 2020 Category: Neurology Authors: Ashkan Mowla, Banafsheh Shakibajahromi, Shima Shahjouei, Afshin Borhani-Haghighi, Nasrin Rahimian, Humain Baharvahdat, Soheil Naderi, Fariborz Khorvash, Davar Altafi, Seyed Amir Ebrahimzadeh, Ghasem Farahmand, Alaleh Vaghefi Far, Vijay K. Sharma, Saeideh Source Type: research

Quantifying regional variations in components of acute stroke unit (ASU) care in the international HeadPoST study
Access to acute stroke unit (ASU) care is known to vary worldwide. We aimed to quantify regional variations in the various components of ASU care. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 14, 2020 Category: Neurology Authors: Menglu Ouyang, Yao Zhang, Xia Wang, Lili Song, Laurent Billot, Thompson Robinson, Pablo M. Lavados, Hisatomi Arima, Maree L. Hackett, Ver ónica V. Olavarría, Paula Muñoz-Venturelli, Sandy Middleton, Caroline L. Watkins, Octavio M. Pontes-Neto, Tsong-Ha Source Type: research

Influence of atrial fibrillation detection time on outcome after endovascular thrombectomy
Cardiac emboli secondary to atrial fibrillation (AF) commonly cause large vessel occlusions (LVO) that require endovascular thrombectomy (EVT) to restore cerebral circulation. Whether the outcome of patients with AF diagnosed after the index stroke (newAF) differs from that of AF-patients in which AF was known before stroke (kAF) remains unknown. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 14, 2020 Category: Neurology Authors: R.R. Leker, A. Farraj, A. Filioglo, T. Sacagiu, A. Honig, J.M. Gomori, J.E. Cohen Source Type: research

Apraclonidine for the pharmacologic confirmation of acute Horner syndrome
Apraclonidine is the most widely used pharmacologic agent to confirm Horner syndrome. It is a strong α-2 and a weak α-1 adrenergic agonist and reversal of anisocoria is considered a positive test. The utility of apraclonidine in acute Horner syndrome remains controversial as the exact timing for denervation sensitivity to develop remains unknown. The goal of this study was to describe the use of apraclonidine in the diagnosis of acute Horner syndrome in patients with an unequivocal onset within 7 days. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 14, 2020 Category: Neurology Authors: Michael T.B. Nguyen, Armin Farahvash, Angela Zhang, Jonathan A. Micieli Tags: Clinical short communication Source Type: research

Magnetic resonance imaging and optical coherence tomography correlations in multiple sclerosis beyond anatomical landmarks
To investigate multiple sclerosis (MS) optical coherence tomography (OCT) cross-sectional correlations with central nervous system (CNS) magnetic resonance imaging (MRI). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 13, 2020 Category: Neurology Authors: Antonio Barreiro-Gonz ález, Maria T. Sanz, Sara Carratalà-Boscà, Francisco Pérez-Miralles, Carmen Alcalá, Joan Carreres-Polo, Enrique España-Gregori, Bonaventura Casanova Source Type: research

Genetic and NONGENETIC factors associated with CADASIL: A retrospective cohort study
Objective: To explore the role of cardiovascular risk factors and the different NOTCH-3 mutations to explain the variability observed in the clinical presentation of CADASIL.Methods: This was a retrospective cohort study of 331 individuals, 90 were carriers of four mutations in the NOTCH3 gene. These four mutations are the ones identified in our region from the genetic evaluation of probands. Cox proportional hazards models were fitted to estimate the effect of genetic and cardiovascular factors on the onset of migraine, first stroke, and dementia. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 12, 2020 Category: Neurology Authors: Carolina Ospina, Joseph F. Arboleda-Velasquez, Daniel Camilo Aguirre-Acevedo, Yesica Zuluaga-Casta ño, Lina Velilla, Gloria P. Garcia, Yakeel T. Quiroz, M.D. Francisco Lopera Source Type: research

Post-COVID 19 Neurological Syndrome (PCNS); a novel syndrome with challenges for the global neurology community
The current COVID-19 pandemic has resulted in a cumulative total of over 34.8 million cases. Over 1 million deaths have now been reported globally, with the majority being reported in the region of the Americas (55%), followed by Europe (23%). Approximately 50% of cases worldwide are in the 25 –64 age group (WHO situation report; accessed October 52,020) though the majority of deaths have occurred in older persons. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 12, 2020 Category: Neurology Authors: Tissa Wijeratne, Sheila Crewther Source Type: research

Between the size and location of myocardial infarction and cerebral infarction
Myocardial infarction (MI) is a known cause of cerebral infarction. We assessed whether the size and location of MI is associated with the risk of cerebral infarction. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 12, 2020 Category: Neurology Authors: Alexander E. Merkler, Javid Alakbarli, Tarek Barbar, Hediyeh Baradaran, Oluwayemisi Adejumo, Babak B. Navi, Hooman Kamel, Jiwon Kim, Peter M. Okin, Ajay Gupta, Jonathan W. Weinsaft Source Type: research

Matrix metalloproteinases deregulation in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of upper and lower motor neurons that results in progressive paralysis and muscular atrophy. There are many molecules and genes involved in neuromuscular degeneration in ALS; among these, matrix metalloproteinases (MMPs). MMPs play an important role in the pathology of ALS, and MMP-1, 2, 3, and 9 might serve as disease progression markers. Tissue inhibitors of metalloproteinases (TIMPS) might also function as progression markers in ALS because they participate in regulating the proteolytic activity of MMPs. (Source: Journal of the ...
Source: Journal of the Neurological Sciences - October 11, 2020 Category: Neurology Authors: Jorge Luis S ánchez-Torres, Petra Yescas Gómez, Julio Torres-Romero, Oscar Rojas Espinosa, Lilia López Canovas, Ángeles C. Tecalco-Cruz, María Dolores Ponce-Regalado, María Elizbeth Álvarez Sánchez Tags: Review Article Source Type: research

Impact of motor and nonmotor symptoms in Parkinson disease for the quality of life: The Japanese Quality-of-Life Survey of Parkinson Disease (JAQPAD) study
Parkinson's disease (PD) is characterized by a range of classic motor symptoms and heterogeneous nonmotor symptoms that affect patients' quality of life (QoL). Studies have individually reported the effect of either motor or nonmotor symptoms on patients' QoL; however, a thorough assessment of the symptoms that have the greatest influence on QoL is limited. This JAQPAD study examined the effect of both motor and nonmotor symptoms and patient demographics on QoL in a large population of patients with PD in Japan. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 10, 2020 Category: Neurology Authors: Kanako Kurihara, Ryoko Nakagawa, Miwako Ishido, Yoko Yoshinaga, Jun Watanabe, Yuka Hayashi, Takayasu Mishima, Shinsuke Fujioka, Yoshio Tsuboi Source Type: research

CT and MR neuroimaging findings in patients with lyme neuroborreliosis: A national prospective cohort study
We aimed to describe the use and findings of cranial computerized tomography (CT-head), spine and brain magnetic resonance imaging (MRI-spine/MRI-brain) in Lyme neuroborreliose (LNB). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 10, 2020 Category: Neurology Authors: Mathilde Ørbæk, Jacob Bodilsen, Rosa M. Møhring Gynthersen, Nitesh Shekhrajka, Cecilie Lerche Nordberg, Lykke Larsen, Merete Storgaard, Christian Brandt, Lothar Wiese, Birgitte Rønde Hansen, Hans R. Luttichau, Aase Bengaard Andersen, Helene Mens, Henr Source Type: research

Cognitive impairment in Parkinson's disease: A clinical and pathophysiological overview
This article aims to compile and briefly summarize selected published data about clinical features, cognitive evaluation, biomarkers, and pathophysiology of PD-related dementia (PDD). The literature search included articles indexed in the MEDLINE/PubMed database, published in English, over the last two decades. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 10, 2020 Category: Neurology Authors: Pedro Renato P. Brand ão, Renato Puppi Munhoz, Talyta Cortez Grippe, Francisco Eduardo Costa Cardoso, Brenda Macedo de Almeida e Castro, Ricardo Titze-de-Almeida, Carlos Tomaz, Maria Clotilde Henriques Tavares Tags: Review Article Source Type: research

MRI phenotyping of underlying cerebral small vessel disease in mixed hemorrhage patients
To investigate underlying cerebral small vessel disease (CSVD) in patients with mixed cerebral hemorrhages patterns and phenotype them according to the contribution of the two most common sporadic CSVD subtypes: cerebral amyloid angiopathy (CAA) vs. hypertensive arteriopathy (HA). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 8, 2020 Category: Neurology Authors: Vincent Scheumann, Frank Schreiber, Valentina Perosa, Anne Assmann, Christian Mawrin, Cornelia Garz, Hans-Jochen Heinze, Michael G örtler, Emrah Düzel, Stefan Vielhaber, Andreas Charidimou, Stefanie Schreiber Source Type: research

Impact of pulmonary embolism on in-hospital mortality of patients with ischemic stroke
Pulmonary embolism (PE) is a frequent complication in immobile stroke patients and an important cause of death in stroke patients. We aimed to investigate predictors of PE and impact of PE on survival of ischemic stroke patients. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 8, 2020 Category: Neurology Authors: Karsten Keller, Lukas Hobohm, Thomas M ünzel, Mareike Lankeit, Mir Abolfazl Ostad Source Type: research

Cerebral micro-infarcts; the hidden missing link to vascular cognitive decline
Cerebral Micro-infarcts; the Hidden Missing Link to Vascular Cognitive Decline. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 5, 2020 Category: Neurology Authors: Asaf Honig, Ronen R. Leker Tags: Editorial Source Type: research

Longer-term effects of intravenous immunoglobulin treatment in chronic inflammatory demyelinating polyneuropathy: Who benefits?
Intravenous immunoglobulins (IVIg) represent an established cornerstone for the immunotherapy of chronic inflammatory demyelinating polyneuropathy (CIDP). Efficacy of IVIg for CIDP was proven in a large phase III trial. Yet, data on longer-term efficacy and effects in distinct subgroups are scarce. Our trial investigates the long-term efficacy of IVIg treatment in CIDP patients.In this observational real-world study, we retrospectively analyzed 49 CIDP patients receiving continuous IVIg treatment with a mean initial dosage of 87  g (1 g/kg body weight) every 4 weeks over a mean time of 45 months between 2010 and 20...
Source: Journal of the Neurological Sciences - October 3, 2020 Category: Neurology Authors: Pauline Terhoeven, Julia Seybold, Kathrin S. Utz, Florian T. Nickel, De-Hyung Lee, Ralf A. Linker Source Type: research

Acute ischemic stroke diagnosis using brain tissue pulsations
This study is the first to explore the clinical potential of measuring BTPs using ultrasound in acute ischemic stroke patients.BTPs were measured in 24 healthy volunteers (aged 52 –82 years) and 14 acute ischemic stroke patients (aged 51–86 years) using a novel Transcranial Tissue Doppler (TCTD) method. Measurements were quick to perform and were well tolerated by all subjects. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 2, 2020 Category: Neurology Authors: Jonathan Ince, Caroline Banahan, Sara Venturini, Meshal Alharbi, Poppy Turner, Mitsuhiro Oura, Kirk W. Beach, Thompson G. Robinson, Amit K. Mistri, Andrea Lecchini-Visintini, Jatinder S. Minhas, Emma M.L. Chung Source Type: research

Cerebral microinfarcts disruption of remote cortical thickness
This study examines CMIs influence on cortical thickness in remote brain areas. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 2, 2020 Category: Neurology Authors: D. Kraushar, J. Molad, H. Hallevi, N.M. Bornstein, E. Ben-Assayag, E. Auriel Source Type: research

Clinical characteristics and diagnostic clues to Neurometabolic causes of dystonia
Neurometabolic causes of dystonia are heterogenous and can be challenging to diagnose, yet many of these disorders are potentially treatable. The first step in the workup is to clinically phenotype the underlying condition, followed by ordering selected diagnostic tests based on the clinician's judgement and clinical suspicion. In this review, we highlight the diagnostic clues to various disorders, including lysosomal storage diseases, mitochondrial cytopathies, metal storage disorders, organic acidurias, disorders in carbohydrate metabolism, neurotransmitter diseases and vitamin and cofactor deficiencies. (Source: Journal...
Source: Journal of the Neurological Sciences - October 2, 2020 Category: Neurology Authors: Chun Seng Phua, Kishore Raj Kumar, Stanley Levy Tags: Review Article Source Type: research

A multi-center, prospective study on the progression rate of asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on magnetic resonance imaging to idiopathic normal pressure hydrocephalus
Introduction: Our previous community-based study demonstrated that some individuals with AVIM [asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus (iNPH) on magnetic resonance imaging (MRI)] progressed to iNPH in several years. In this hospital-based study, we investigated the progression rate from AVIM to iNPH and its possible predictors.Methods: We conducted a prospective study of participants with AVIM from several medical institutions/hospitals in Japan. AVIM is defined as “asymptomatic ventriculomegaly with features of iNPH on MRI”; in the present study, asymptomatic was...
Source: Journal of the Neurological Sciences - October 1, 2020 Category: Neurology Authors: Luna Kimihira, Chifumi Iseki, Yoshimi Takahashi, Hidenori Sato, Hajime Kato, Hiroaki Kazui, Nagato Kuriyama, Madoka Nakajima, Masakazu Miyajima, Katsuhiro Endo, Yoshio Kobayashi, Takashi Saegusa, Yasuaki Takeda, Shunsuke Sato, Yusuke Tomogane, Toru Baba, Tags: Clinical short communication Source Type: research

Trends in hospitalizations and epidemiological characteristics of adults Moyamoya disorder in the United States
There has been an increasing prevalence of Moyamoya disorder (MMD) reported from recent US literature. There is a paucity of data available regarding trends of prevalence and epidemiological factors in the United States. To test the hypothesis that racial-, sex-specific MMD hospitalizations and epidemiological factors have been increasing in the United States over the last decade. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 1, 2020 Category: Neurology Authors: Smit D. Patel, Ninad Desai, Schweta Rane, Neel Patel, Rupak Desai, Tapan Mehta, Martin D. Ollenschleger, Anil Nanda, Robert M. Starke, Priyank Khandelwal Source Type: research

The learning effect of the King-Devick test in semi-professional rugby union athletes
Abnormalities of eye movement and visual processing are common in traumatic brain injury. The King-Devick test (KDT) has been widely used in the detection and recovery of concussion. Current recommendations propose performing the initial test at baseline and then repeating annually to account for potential learning effects. In practice, this may still account for large deviations. The aim of this study was to determine the number of trials needed for a player to achieve a ceiling effect and to determine the validity of the existing protocol requiring two tests at baseline. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 1, 2020 Category: Neurology Authors: Premkumar Gunasekaran, Clare L. Fraser, Christopher Hodge Source Type: research

Anosmia is associated with lower in-hospital mortality in COVID-19
Anosmia is common in Coronavirus disease 2019, but its impact on prognosis is unknown. We analysed whether anosmia predicts in-hospital mortality; and if patients with anosmia have a different clinical presentation, inflammatory response, or disease severity. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 29, 2020 Category: Neurology Authors: Blanca Talavera, David Garc ía-Azorín, Enrique Martínez-Pías, Javier Trigo, Isabel Hernández-Pérez, Gonzalo Valle-Peñacoba, Paula Simón-Campo, Mercedes de Lera, Alba Chavarría-Miranda, Cristina López-Sanz, María Gutiérrez-Sánchez, Elena Mart Source Type: research

Role for OCT in detecting hemi-macular ganglion cell layer thinning in patients with multiple sclerosis and related demyelinating diseases
Investigations have found associations of homonymous thinning of the macular ganglion cell/ inner-plexiform layer (GCIPL) with demyelinating lesions in the post-chiasmal visual pathway among patients with multiple sclerosis (MS). Retinal thinning may also occur through retrograde trans synaptic degeneration, a process by which lesions in post-geniculate visual pathway structures lead to thinning of the GCIPL across thalamic synapses. The purpose of our study was to determine the frequency of homonymous hemimacular thinning that occurs in association with post-chiasmal visual pathway demyelinating lesions in patients with M...
Source: Journal of the Neurological Sciences - September 27, 2020 Category: Neurology Authors: Marissa Ilardi, Rachel Nolan-Kenney, Girish Fatterpekar, Lisena Hasanaj, Liliana Serrano, Binu Joseph, Shirley Wu, Janet C. Rucker, Laura J. Balcer, Steven L. Galetta Source Type: research

Junctional dilatation of the basilar tip: A Normal anatomical variant with a benign natural history
The intracranial arterial vasculature has numerous anatomical variants, which vary from largely benign to having remarkable clinical implications. The significance of a lesser known variant described as a junctional dilatation of the basilar artery tip has not yet been described in the literature. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 27, 2020 Category: Neurology Authors: Kevin McElroy, Waleed Brinjikji Source Type: research

Use of the King-Devick test for the identification of concussion in an amateur domestic women's rugby union team over two competition seasons in New Zealand
To investigate the use of the King-Devick (K-D) test for sideline assessment of concussive injuries in a New Zealand amateur women's rugby union team. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 27, 2020 Category: Neurology Authors: D. King, P.A. Hume, T.N. Clark, A.J. Pearce Source Type: research

Bilateral optic disc edema with preserved visual function not related to papilledema
Bilateral optic disc edema (ODE) with preserved visual function is typically a result of papilledema, but the causes of this finding in the absence of raised intracranial pressure have not been systematically evaluated. The goal of this study was to determine the causes of bilateral ODE with preserved visual function not related to intracranial hypertension to help in developing a differential diagnosis for this finding. We retrospectively reviewed 221 consecutive patients presenting to a tertiary neuro-ophthalmology practice over a period of 2  years. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 26, 2020 Category: Neurology Authors: Caberry W. Yu, Jonathan A. Micieli Tags: Clinical short communication Source Type: research

Antecedent febrile illness and occurrence of stroke in West Africa: The SIREN study
Acute infections have been posited as potential precipitants or triggers of the occurrence of stroke among adults with traditional vascular risk factors. We evaluated associations between stroke occurrence and reported febrile illness within 4  weeks (potential antecedent infections) among West Africans. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 24, 2020 Category: Neurology Authors: Fred Stephen Sarfo, Bruce Ovbiagele, Onoja Akpa Matthew, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Lukman Owolabi, Osahon Asowata, Godwin Ogbole, Morenikeji Komolafe, Rufus Akinyemi, Mayowa Owolabi, on behalf of SIREN Source Type: research

Longitudinal evolution of non-motor symptoms according to age at onset in early Parkinson's disease
To investigate the longitudinal change of non-motor symptoms according to the age at onset in Parkinson's disease (PD). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 22, 2020 Category: Neurology Authors: Ryul Kim, Jung Hwan Shin, Sangmin Park, Han-Joon Kim, Beomseok Jeon Source Type: research

Inpatient diagnoses of idiopathic normal pressure hydrocephalus in the United States: Demographic and socioeconomic disparities
Epidemiology provides an avenue for identifying disease pathogenesis, hence determining national incidence, along with socioeconomic and demographic variables involved in iNPH, can provide direction in elucidating the etiology and addressing healthcare inequalities. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 22, 2020 Category: Neurology Authors: Arash Ghaffari Rafi, Rana Mehdizadeh, Shadeh Ghaffari Rafi, Jose Leon Rojas Source Type: research

Novel TRPV4 mutation in a large Chinese family with congenital distal spinal muscular atrophy, skeletal dysplasia and scaly skin
This study describes a large Chinese family with a novel mutation in the TRPV4 gene. Nineteen individuals from this family were investigated. Clinical, electrophysiological, and radiographic examinations were performed. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 21, 2020 Category: Neurology Authors: Ying Liu, Xuejing Yan, Yongzhen Chen, Zhiyi He, Yi Ouyang Tags: Clinical short communication Source Type: research

Genetic analysis of the first SCA36 family showing clinical anticipation
Spinocerebellar ataxia type 36 (SCA36) is an autosomal dominant, slowly progressive cerebellar syndrome caused by unstable large expansion of GGCCTG hexanucleotide repeat (normal: 3 –14 repeats, disease: 650–2500 repeats) in the first intron of the nucleolar protein 56 gene [1–3]. I read with interest the article by Ota et al. [4], which genetically characterized the first Japanese SCA36 family showing clinical anticipation. So far, there had been no or little evidence of association between number of GGCCTG repeat and age at onset of SCA36 patients. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 21, 2020 Category: Neurology Authors: Tohru Matsuura Tags: Letter to the Editor Source Type: research

Severe disease activity in MS patients treated with cladribine after fingolimod withdrawal
Dear Editor, (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 21, 2020 Category: Neurology Authors: Maria Cellerino, Simona Bonavita, Margherita Ferrero, Matilde Inglese, Giacomo Boffa Tags: Letter to the Editor Source Type: research

Interictal hemodynamic abnormality during motor activation in sporadic hemiplegic migraine: An explorative study
The motor weakness in sporadic hemiplegic migraine (SHM) is a poorly understood aura manifestation. Cortical spreading depression affecting motor excitability and alterations of neurovascular coupling may be integral to the development of migraine aura. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 20, 2020 Category: Neurology Authors: Y.L. Lo, S.L. Wee, Y.J. Zhao, K. Narasimhalu Source Type: research

Repeat sizes of NOP56 gene in a Japanese Asidan (SCA36) family with clinical anticipation
We appreciate the criticism raised by Dr. Matsuura questioning the genetic evaluation for NOP56 gene of Asidan (spinocerebellar ataxia 36) showing clinical anticipation. Asidan is an autosomal dominant neurodegenerative disorder caused by a hexanucleotide GGCCTG repeat expansion in intron 1 of the NOP56 gene, showing cerebellar ataxia, motor neuron disease phenotype, hearing loss and frontal cognitive impairment [1 –3]. The NOP56 genetic mutation in Asidan is similar to the hexanucleotide GGGGCC repeat expansion in intron 1 of the C9orf72 gene observed in familial amyotrophic lateral sclerosis/frontotemporal dementia...
Source: Journal of the Neurological Sciences - September 19, 2020 Category: Neurology Authors: Yasuyuki Ohta, Ken Ikegami, Kota Sato, Nozomi Hishikawa, Yoshio Omote, Mami Takemoto, Toru Yamashita, Koji Abe Tags: Letter to the Editor Source Type: research

Transcranial magnetic stimulation, deep brain stimulation, and other forms of neuromodulation for substance use disorders: Review of modalities and implications for treatment
Given the high prevalence of individuals diagnosed with substance use disorder, along with the elevated rate of relapse following treatment initiation, investigating novel approaches and new modalities for substance use disorder treatment is of vital importance. One such approach involves neuromodulation which has been used therapeutically for neurological and psychiatric disorders and has demonstrated positive preliminary findings for the treatment of substance use disorder. The following article provides a review of several forms of neuromodulation which warrant consideration as potential treatments for substance use dis...
Source: Journal of the Neurological Sciences - September 19, 2020 Category: Neurology Authors: James J. Mahoney, Colleen A. Hanlon, Patrick J. Marshalek, Ali R. Rezai, Lothar Krinke Tags: Review Article Source Type: research

COVID-19 in multiple sclerosis patients and risk factors for severe infection
Multiple sclerosis (MS) patients have been considered a higher-risk population for COVID-19 due to the high prevalence of disability and disease-modifying therapy use; however, there is little data identifying clinical characteristics of MS associated with worse COVID-19 outcomes. Therefore, we conducted a multicenter prospective cohort study looking at the outcomes of 40 MS patients with confirmed COVID-19. Severity of COVID-19 infection was based on hospital course, where a mild course was defined as the patient not requiring hospital admission, moderate severity was defined as the patient requiring hospital admission to...
Source: Journal of the Neurological Sciences - September 18, 2020 Category: Neurology Authors: Farhan ChaudhryMS, Helena BulkaDO, Anirudha S. RathnamMD, Omar M. SaidBS, Jia LinMD, Holly LoriganDO, Eva BernitsasMD, Jacob RubeMD, Steven J. KorzeniewskiPhD, Anza B. MemonMD, Phillip D. LevyMD, Lonni SchultzPhD, Adil JavedMD, Robert LisakMD, Mirela Cerg Source Type: research