Change in visual acuity and retinal structures following Repository Corticotropin Injection (RCI) therapy in patients with acute demyelinating optic neuritis: Improvement in low contrast visual acuity in both affected and contralateral eyes in a single-armed open-label study
Current treatments after an episode of optic neuritis have limited success protecting the retinal nerves and restoring visual function. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 22, 2019 Category: Neurology Authors: Molly Scannell Bryan, Robert C. Sergott Source Type: research

Deep brain stimulation hardware-related complications and their management: A single-center retrospective analysis of 65 patients with various dystonic conditions
1.Slipped connector to the retromastoid area where the skin is thin and prone to erode caused the visible erosion without visible signs of contaminant infection. The connector is clearly visible thought the eroded skin. 2. The erosion over the right implantable pulse generator in the subclavicular area. 3. The infected slipped connector to the retromastoid region with visible hardware (connector and proximal part of connection wire). 4. Large infected erosion of the implantable pulse generator in the left subclavicular area with sings of infection (redness of the skin without purulent leakage). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 22, 2019 Category: Neurology Authors: Micha ł Sobstyl, Angelika Stapińska-Syniec, Jakub Giziński, Tomasz Kmieć, Anna Kupryjaniuk Source Type: research

Correlating diffusion-weighted MRI intensity with type 2 pathology in mixed MM-type sporadic Creutzfeldt-Jakob disease
In this study, we attempted to clinically predict the concurrence of MM-type sCJD with another PrPSc type in the same individual. We retrospectively identified seven MM-type sCJD cases with both fine vacuole-type spongiform (FV) and large confluent vacuole-type spongiform change (LCV) among 49 sCJD cases. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 22, 2019 Category: Neurology Authors: Toshimasa Ikeda, Yasushi Iwasaki, Keita Sakurai, Akio Akagi, Yuichi Riku, Maya Mimuro, Hiroaki Miyahara, Tetsuyuki Kitamoto, Noriyuki Matsukawa, Mari Yoshida Source Type: research

Discriminating chorea-acanthocytosis from Huntington's disease with single-case voxel-based morphometry analysis
Chorea-acanthocytosis is clinically difficult to distinguish from Huntington's disease because these disorders have similar symptoms and MR imaging findings. We evaluated the usefulness of single-case voxel-based morphometry (VBM) analysis for differentiating the two diseases as well as VBM analysis. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 21, 2019 Category: Neurology Authors: Fumio Suzuki, Noriko Sato, Miho Ota, Atsuhiko Sugiyama, Yoko Shigemoto, Emiko Morimoto, Yukio Kimura, Noritaka Wakasugi, Yuji Takahashi, Akinori Futamura, Mitsuru Kawamura, Kenjiro Ono, Masayuki Nakamura, Akira Sano, Masako Watanabe, Hiroshi Matsuda, Osam Source Type: research

Involvement of legs and other body parts in patients with restless legs syndrome and its variants
Restless legs syndrome (RLS) is characterized by the urge to move the legs accompanied by movement-responsive, abnormal sensations, which worsen at rest and night. We investigated the distribution of sensory symptoms and clinical correlations in patients with RLS and its variants. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 20, 2019 Category: Neurology Authors: Keisuke Suzuki, Shiho Suzuki, Masayuki Miyamoto, Tomoyuki Miyamoto, Takeo Matsubara, Narihiro Nozawa, Takuo Arikawa, Itsuo Nakajima, Koichi Hirata Source Type: research

Cause of acquired onset of diplopia due to isolated third, fourth, and sixth cranial nerve palsies in patients aged 20 to 50  years in Korea: A high resolution magnetic resonance imaging study
This study aimed to describe the etiologies of acquired onset of diplopia due to isolated third, fourth, and sixth cranial nerve palsies in young adults in Korea. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 19, 2019 Category: Neurology Authors: Kyung-Ah Park, Sei Yeul Oh, Ju-Hong Min, Byoung Joon Kim, Yikyung Kim Source Type: research

Preoperative risks of post-operative myasthenic crisis (POMC): A meta-analysis
Myasthenic crisis (MC) is a life-threatening condition in patients with myasthenia gravis (MG), for which thymectomy is known to be a predisposing factor. There are many preoperative factors that have been suggested to increase the occurrence of post-operative myasthenic crisis (POMC), but none have been unanimously concluded as definite risk factors. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 18, 2019 Category: Neurology Authors: Tetsuya Akaishi, Masakatsu Motomura, Hirokazu Shiraishi, Shunsuke Yoshimura, Michiaki Abe, Tadashi Ishii, Masashi Aoki Source Type: research

Factors contributing to delays in the diagnosis of motor neuron disease – A south Australian study
To characterize the clinical factors that influence time to diagnosis of motor neuron disease (MND) in a cohort of patients living in South Australia. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 18, 2019 Category: Neurology Authors: Dale F. Sharrad, David W. Schultz Source Type: research

Complement deposition and macrophage-induced demyelination in CIDP with anti-LM1 antibodies
Although the diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) is usually based on clinical and electrophysiological criteria, recent studies have focused on autoantibodies as biomarkers in a subpopulation of patients with this disease [1,2]. Among these antibodies, those directed against LM1, a major human peripheral nerve glycolipid [3], have also been reported in a subset of CIDP patients [4 –7]. Patients with these autoantibodies tend to be elderly, male, have less frequent cranial nerve involvement, and experience more frequent ataxia [4]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 17, 2019 Category: Neurology Authors: Haruki Koike, Shohei Ikeda, Yuki Fukami, Ryoji Nishi, Yuichi Kawagashira, Masahiro Iijima, Tomohiko Nakamura, Motoi Kuwahara, Susumu Kusunoki, Masahisa Katsuno, Gen Sobue Tags: Letter to the Editor Source Type: research

Antidepressants and Parkinson's disease: a causal association
Zenesini et al. investigated the association between the use of antidepressants and subsequent Parkinson's disease (PD) onset by a historical cohort study [1]. By using time-dependent Cox regression analysis, adjusted hazard ratio (HR) (95% confidence interval [CI]) of the use of antidepressants for PD onset was 1.7(1.3 –2.3). By stratified analysis, adjusted HRs (95% CIs) in males and subjects ≤65 years of age were 2.2 (1.5–3.2) and 2.4 (1.6–3.6), respectively. The authors concluded that the patients with depression preceded the onset of PD, and I have two concerns about their study. (Source: Journal ...
Source: Journal of the Neurological Sciences - October 17, 2019 Category: Neurology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research

Hospital admission and prevalence trends of adult myasthenia gravis in Finland in 2004 –2014: A retrospective national registry study
Hospital admission trends in Myasthenia Gravis are largely unknown, so they were here investigated in Finland between 2004 and 2014 using national mandatory registry data. There were 2989 hospital admissions (59.7% for women) for 861 individuals (median 2 admissions/individual) The annual number of admissions (p  = .56), the age of admitted patients (p = .24) or length of stay (p = .20) showed no change during the study period. The proportion of infections as the primary diagnosis increased from 4.5% to 10.4% (p = .0056). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 17, 2019 Category: Neurology Authors: Jussi O.T. Sipil ä, Merja Soilu-Hänninen, Päivi Rautava, Ville Kytö Source Type: research

Impaired cerebrovascular reactivity may predict delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
Delayed cerebral ischemia (DCI) is a major cause of disability and death after aneurysmal subarachnoid hemorrhage. The literature suggests that impaired cerebrovascular reactivity (CVR) may be a predictor for DCI; still no CVR based prediction model has been developed. Increased knowledge about possible predictors of DCI can improve patient management in high-risk patients and allow for shorter hospital stay in low-risk patients. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 17, 2019 Category: Neurology Authors: Marianne L. B øthun, Øystein A. Haaland, Gunnar Moen, Nicola Logallo, Frode Svendsen, Lars Thomassen, Christian A. Helland Source Type: research

Paraspinal amyotrophy in DNM-2-related centronuclear myopathy
Centronuclear myopathy (CNM) is a rare congenital myopathy characterized by the morphological feature of centrally located nuclei in a large number of muscle fibers. CNM is related to several causative genes: dynamin 2 (DNM2), myotubularin (MTM1), amphiphysin 2 (BIN1), and ryanodine receptor 1 (RYR1) [1]. DNM2-related CNM (DNM2-CNM) is an autosomal-dominant inherited disease that accounts for about 50% of CNM cases [1]. Although DNM2-CNM has shown a variety of clinical manifestations, from severe neonatal onset to mild adult onset, most patients present with slowly progressive muscle weakness in the distal or sometimes pro...
Source: Journal of the Neurological Sciences - October 16, 2019 Category: Neurology Authors: Kensuke Kakiuchi, Kiichi Unoda, Hideto Nakajima, Ichizo Nishino, Shigeki Arawaka Tags: Letters to the Editor Source Type: research

Clinical characteristics, EEG findings and implications of status epilepticus in patients with brain metastases
To evaluate the clinical implications of status epilepticus in patients with metastases to the brain as well as associated demographic, clinical, EEG and radiographic features. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 16, 2019 Category: Neurology Authors: Jonah Fox, Shaun Ajinkya, Adam Greenblatt, Peter Houston, Alain Lekoubou, Scott Lindhorst, David Cachia, Adriana Olar, Ekrem Kutluay Source Type: research

Comparative discontinuation, effectiveness, and switching practices of dimethyl fumarate and fingolimod at 36-month follow-up
Dimethyl fumarate (DMF) and fingolimod (FTY) are approved oral disease modifying therapies (DMTs) for relapsing multiple sclerosis (MS). There are currently no known head-to-head studies comparing DMF and FTY over 36  months, which leaves their relative effectiveness unknown. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 15, 2019 Category: Neurology Authors: Brandi Vollmer, Daniel Ontaneda, Haleigh Harris, Kavita Nair, Robert A. Bermel, John R. Corboy, Robert J. Fox, Timothy Vollmer, Jeffrey A. Cohen, Enrique Alvarez, Carrie M. Hersh Source Type: research

Patients with MELAS with negative myopathology for characteristic ragged-red fibers
We report a series of patients with MELAS without significant myopathic changes. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 15, 2019 Category: Neurology Authors: Yuanyuan Lu, Jianwen Deng, Yuying Zhao, Zhe Zhang, Daojun Hong, Sheng Yao, Danhua Zhao, Jie Xie, Hezhi Fang, Yun Yuan, Zhaoxia Wang Source Type: research

Rate of force development and relaxation scaling factors are highly sensitive to detect upper extremity motor impairments in multiple sclerosis
Clinical assessment of upper extremity in multiple sclerosis is mainly limited to 9-hole peg test (9-HPT), which is commonly criticized due to its limited sensitivity. There is a need for sensitive outcome measures for the assessment of motor symptoms in individuals with multiple sclerosis (iMS). We evaluated our recently developed brief force pulse protocol to simultaneously quantify the motor control of hand function and neuromuscular quickness in iMS. Additionally, we compared the sensitivity of the studied outcome measures with 9-HPT in detecting the differences between iMS and controls. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 15, 2019 Category: Neurology Authors: Mehmet Uygur, Paulo B. de Freitas, Donald A. Barone Source Type: research

Branchial myorhythmia in a case of systemic lupus erythematosus
Myoclonus is characterized by sudden, brief, shock-like movements involving the extremities, face, and trunk [1]. Myoclonus is commonly classified into cortical, brainstem and spinal forms according to its presumed origin [2,3]. Myorhythmia has similar characteristics, but is distinguished from myoclonus by its rhythmicity (1 –4 Hz) and slower muscle contractions (~200 msec) [4]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 15, 2019 Category: Neurology Authors: Hayato Une, Dai Matsuse, Taira Uehara, Yoshikazu Kikuchi, Saeko Inamizu, Ryo Yamasaki, Shozo Tobimatsu, Hiroshi Shibasaki, Jun-ichi Kira Tags: Letter to the Editor Source Type: research

Nerve transfer as a novel treatment for West Nile virus-associated acute flaccid paralysis
West Nile virus-associated acute flaccid paralysis (WNV-AFP) is a well-known complication of West Nile neuroinvasive disease (WNND) [1,2]. Most cases of WNV-AFP occur as a result of anterior horn cell damage, resulting in a syndrome reminiscent of poliomyelitis. Brachial plexus involvement has been reported less commonly [3 –5]. At present, supportive care is the mainstay of treatment for all forms of WNND [2]. The prognosis for WNV-AFP is generally poor, and recovery, if any, usually occurs within six months of onset [6]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 15, 2019 Category: Neurology Authors: Anson W. Wilks, Wilson Z. Ray, Muhammad T. Al-Lozi, Robert C. Bucelli Tags: Letter to the Editor Source Type: research

Clinical characteristics of bulbar involvement in spinal and bulbar muscular atrophy - Effects of palatal lift prosthesis on dysarthria and dysphagia
Spinal and bulbar muscular atrophy (SBMA) is a hereditary neuromuscular disease affecting only males characterized by progressive muscular atrophy and weakness in bulbar and limb muscles. The present study aimed to evaluate the features of velopharyngeal dysfunction (VPD) in SBMA subjects by an acoustic analysis of speech. Twenty-three genetically confirmed patients with SBMA were enrolled and assessed their speech by measuring the nasalance score with a Nasometer II. The nasalance scores of the SBMA group was higher than that of healthy controls (p  = .035) and significantly correlated with the total score of the revi...
Source: Journal of the Neurological Sciences - October 15, 2019 Category: Neurology Authors: Seiya Tanaka, Atsushi Hashizume, Yasuhiro Hijikata, Shinichiro Yamada, Daisuke Ito, Atsushi Nakayama, Kenichi Kurita, Hiroaki Yogo, Haruhiko Banno, Keisuke Suzuki, Masahiko Yamamoto, Gen Sobue, Masahisa Katsuno Source Type: research

A prediction model of brain edema after endovascular treatment in patients with acute ischemic stroke
Clinical tools predicting brain edema after reperfusion therapy in acute ischemic stroke are scarce. We aim to develop a nomogram model to predict brain edema within the first 24  h after endovascular treatment (EVT) in the anterior cerebral circulation. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 15, 2019 Category: Neurology Authors: Xiangliang Chen, Qing Huang, Qiwen Deng, Rui Shen, Yukai Liu, Min Lu, Hongchao Shi, Junshan Zhou Source Type: research

Interfacility transfer for mechanical thrombectomy – Direct to neuroangiography or CT angiography first?
Faster time to mechanical thrombectomy (MT) improves outcome in stroke. In patients from other hospitals where a CT has ruled-out hemorrhage, transfer direct-to-angiography (DTA) may reduce door-to-groin time compared to transfer to CT angiography (CTA)+/ −repeat CT first. However, this may result in unnecessary catheter angiography. We sought to determine how often CTA+/−CT changed the decision to proceed to MT. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 15, 2019 Category: Neurology Authors: Kelley Humbert, Michele Sellers, Elizabeth Neuhaus-Booth, Steven R. Messe, Bryan Pukenas, Brett Cucchiara Source Type: research

Functional analysis of a double-point mutation in the KCNJ2 gene identified in a family with Andersen-Tawil syndrome
Andersen-Tawil syndrome (ATS) is a skeletal muscle channelopathy with autosomal dominant inheritance resulting in periodic paralysis, arrhythmia characterized by QT prolongation, and dysmorphic features. The KCNJ2 gene has been identified as the causative gene of ATS. Herein, we reported 2 cases of a 21-year-old man and his mother, with episodic paralytic attacks and/or arrhythmia, which are characteristic of ATS. Both G144A, a reported ATS mutation, and V296F, a novel mutation, were identified in the KCNJ2 gene on the same allele from the proband and his mother, but not from his father. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 15, 2019 Category: Neurology Authors: Shinobu Fukumura, Kosuke Yamauchi, Akira Kawanabe, Akiyo Yamamoto, Maki Nakaza, Tomoya Kubota, Shinsuke Kato, Ryogen Sasaki, Yasushi Okamura, Masanori P. Takahashi Source Type: research

Mild cognitive impairment and dementia in motor manifest Huntington's disease: Classification and prevalence
To identify the characteristics and prevalence of mild cognitive impairment in patients with motor-manifest Huntington's disease (HD) and to propose a new mild cognitive impairment (HD-MCI) classification for HD. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 15, 2019 Category: Neurology Authors: Parunyou Julayanont, Nikolaus R. McFarland, Kenneth M. Heilman Source Type: research

Safety and pharmacodynamics of a novel recombinant botulinum toxin E (rBoNT-E): Results of a phase 1 study in healthy male subjects compared with abobotulinumtoxinA (Dysport ®)
Naturally occurring botulinum toxin (BoNT) serotypes have different pharmacological features of therapeutic and aesthetic interest. This phase 1, double-blind, placebo-controlled study (EudraCT: 2016 –002609-20) assessed safety, tolerability and pharmacodynamics (PD) of the first recombinant BoNT serotype E (rBoNT-E) versus abobotulinumtoxinA (Dysport®), administered to extensor digitorum brevis (EDB) of healthy males. Subjects were randomised 3:1 (n = 28) to single ascending rBoNT-E (0.0 4–3.6 ng) doses or placebo. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 13, 2019 Category: Neurology Authors: Laurent Pons, Claire Vilain, Magali Volteau, Philippe Picaut Source Type: research

Multidisciplinary rehabilitation reduces hypothalamic grey matter volume loss in individuals with preclinical Huntington's disease: A nine-month pilot study
Hypothalamic pathology is a well-documented feature of Huntington's disease (HD) and is believed to contribute to circadian rhythm and habitual sleep disturbances. Currently, no therapies exist to combat hypothalamic changes, nor circadian rhythm and habitual sleep disturbances in HD. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 13, 2019 Category: Neurology Authors: Danielle M. Bartlett, Juan F. Dominguez D, Alpar S. Lazar, Catarina C. Kordsachia, Tim J. Rankin, Johnny Lo, Andrew D. Govus, Brian D. Power, Amit Lampit, Peter R. Eastwood, Mel R. Ziman, Travis M. Cruickshank Source Type: research

Association between nonalcoholic fatty liver disease with advanced fibrosis and stroke
There is an increasing appreciation of the cardiovascular implications of nonalcoholic fatty liver disease with advanced fibrosis (NAFLD-fibrosis). However, data regarding stroke risk are limited. We sought to investigate whether NAFLD-fibrosis is associated with stroke in addition to heart disease. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 13, 2019 Category: Neurology Authors: Neal S. Parikh, Lisa B. VanWagner, Mitchell S.V. Elkind, Jose Gutierrez Source Type: research

Quantifying iron deposition in the cerebellar subtype of multiple system atrophy and spinocerebellar ataxia type 6 by quantitative susceptibility mapping
We used quantitative susceptibility mapping (QSM) to assess the brain iron deposition in 28 patients with the cerebellar subtype of multiple system atrophy (MSA-C), nine patients with spinocerebellar ataxia type 6 (SCA6), and 23 healthy controls. Two reviewers independently measured the mean QSM values in brain structures including the putamen, globus pallidus, caudate nucleus, red nucleus, substantia nigra, and cerebellar dentate nucleus. A receiver operating characteristics (ROC) analysis was performed to assess the diagnostic usefulness of the QSM measurements. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 13, 2019 Category: Neurology Authors: Atsuhiko Sugiyama, Noriko Sato, Yukio Kimura, Hiroyuki Fujii, Norihide Maikusa, Yoko Shigemoto, Fumio Suzuki, Emiko Morimoto, Kyosuke Koide, Yuji Takahashi, Hiroshi Matsuda, Satoshi Kuwabara Source Type: research

Genetic risk of Spontaneous intracerebral hemorrhage: Systematic review and future directions
Although highly heritable, few genes have been linked to spontaneous intracerebral hemorrhage (SICH), which does not currently have any evidence-based disease-modifying therapy. Individuals of African ancestry are especially susceptible to SICH, even more so for indigenous Africans. We systematically reviewed the genetic variants associated with SICH and examined opportunities for rapidly advancing SICH genomic research for precision medicine. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 13, 2019 Category: Neurology Authors: Kolawole Wasiu Wahab, Hemant K. Tiwari, Bruce Ovbiagele, Fred Sarfo, Rufus Akinyemi, Matthew Traylor, Charles Rotimi, Hugh Stephen Markus, Mayowa Owolabi Tags: Review Article Source Type: research

Is there a timing for sensitivity to acute cerebral ischemia in migraine patients?
Migraine may be a factor of increased cerebral sensitivity to ischemia. Previous studies were conducted within 6 to 72 after stroke onset. We aimed to determine if an accelerated infarct growth exists in migraine patients within the first 4.5  h. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 13, 2019 Category: Neurology Authors: Isabelle Francillard, Lou Grangeon, Agathe Cornillot, Estelle Houivet, Ozlem Ozkul-Wermester, Aude Triquenot-Bagan, Benjamin Hebant, David Maltete, Emmanuel Gerardin, Evelyne Guegan-Massardier Source Type: research

More than hemifacial spasm? A case of unilateral facial spasms with systematic review of red flags
In this report, we present a case of UFS, not due to HFS, highlighting clinical red flags for an alternative diagnosis. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 13, 2019 Category: Neurology Authors: Jirada Sringean, Dirk Dressler, Roongroj Bhidayasiri Tags: Letter to the Editor Source Type: research

Physical activity, sedentary behavior, and restless legs syndrome in persons with multiple sclerosis
The present study examined the relationships among parameters (i.e., volume and pattern) of physical activity and sedentary behavior with the presence and severity of restless legs syndrome(RLS) in adults with multiple sclerosis(MS). Participants with MS (N  = 253) wore an accelerometer for a 7-day period and completed the Cambridge-Hopkins Restless Legs Syndrome Questionnaire, the International Restless Legs Syndrome Study Group Scale (IRLS), and the Patient Determined Disease Steps scale. Sixty-six (26%) persons with MS had RLS (MS + RLS). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 12, 2019 Category: Neurology Authors: Katie L.J. Cederberg, Brenda Jeng, Jeffer E. Sasaki, Tiffany J. Braley, Arthur S. Walters, Robert W. Motl Source Type: research

Tau progression in single severe frontal traumatic brain injury in human brains
The neuropathological features of chronic traumatic encephalopathy (CTE), caused by repeated traumatic brain injury (TBI), include abnormal accumulations of hyper-phosphorylated tau (p-tau) protein in neurons, neurites and astrocytes, considered to progress via neuronal circuits in brains. Some previous reports suggest that a single severe TBI (sTBI) can also induce CTE and p-tau accumulation, but it is not clear whether the pathology is the same as that of repetitive TBI (rTBI). Since prefrontal leucotomy could be regarded as a model of sTBI, in this study we evaluated two autopsied schizophrenia with this procedure. (Sou...
Source: Journal of the Neurological Sciences - October 9, 2019 Category: Neurology Authors: Yasushi Okamura, Ito Kawakami, Katsushige Watanabe, Kenichi Oshima, Kazuhiro Niizato, Kenji Ikeda, Haruhiko Akiyama, Masato Hasegawa Source Type: research

Screening for urinary tract colonisation prior to corticosteroid administration in acute multiple sclerosis relapses: Validation of an updated algorithm
To evaluate an updated algorithm in the detection of urinary tract infection (UTI) prior to high-dose corticosteroid treatment in acute relapses in multiple sclerosis (MS). This updated algorithm aimed to decrease the unnecessary use of antibiotics, whilst maintaining accuracy and safety. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 16, 2019 Category: Neurology Authors: Fergus O'Herlihy, Nevin A. John, Vivien Li, Bernadette Porter, Lucy Lyons, Martin Rakusa, Carmel Curtis, Jalesh Panicker, Jeremy Chataway Tags: Clinical Short Communication Source Type: research

Relevance of cerebrospinal fluid findings in patients with multiple sclerosis and seizures
Seizures occur 2 –3 times more frequently in Multiple Sclerosis (MS) patients compared to the general population. The prevalence of seizures is reported to be 1.5–7.8% in MS population. However, it is unclear if seizure is an indirect symptom of neuroinflammation in MS. In our study, we explored the relevance of cerebrospinal fluid (CSF) findings in this unique patient cohort with MS and seizures. We retrospectively reviewed the charts of 32 MS patients with subsequent seizures (MSSS) and 12 patients with seizures followed by MS (SFMS). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 16, 2019 Category: Neurology Authors: S. Sriwastava, K. Yarraguntla, D. Zutshi, M.M. Basha, E. Bernitsas, R. Marawar Tags: Clinical short communication Source Type: research

Serum cholesterol, body mass index and smoking status do not predict long-term cognitive impairment in stroke elderly patients
Older stroke survivors are at risk of long-term cognitive impairment, which is associated with a number of modifiable and non-modifiable factors. We aimed to assess the association between the modifiable risk factors, serum cholesterol, low density lipoprotein, high density lipoprotein, serum triglycerides, body mass index (BMI) and smoking status on cognitive function, while controlling for the non-modifiable factors, acute functional impairment, diabetes status and age. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 14, 2019 Category: Neurology Authors: MichaelaC. Pascoe, Chantal F. Ski, David R. Thompson, Thomas Linden Source Type: research

Post-intervention qualitative assessment of mobile health technology to manage hypertension among Ghanaian stroke survivors
Stroke is a leading cause of death in Africa and a key modifiable risk factor for the index and recurrent stroke is through the adequate management of blood pressure. Recent guidelines encourage management beyond clinic settings, yet implementation of these guidelines can be challenging, especially in resource constrained regions, such as in Sub-Saharan Africa. Mobile health technology may offer an innovative and cost-effective approach to improve BP monitoring and facilitate adherence to antihypertensive medications. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 13, 2019 Category: Neurology Authors: Michelle Nichols, Arti Singh, Fred Stephen Sarfo, Frank Treiber, Raelle Tagge, Carolyn Jenkins, Bruce Ovbiagele Source Type: research

Response to “Letter to the editors in regard to the article ‘Genetic heterogeneity of mitochondrial genome in thiamine deficient Leigh syndrome patients’”
We would like to thank Dr. Josef Finsterer for the inquiry regarding our study [1]. As per the main concern of Dr. Josef towards the pathogenic nature of all the identified variations of mitochondrial DNA of Leigh syndrome (LS) patients, we would like to mention that in our study [1], we have primarily highlighted the level of genetic heterogeneity in mitochondrial DNA of thiamine deficient LS patients. Further based upon the association of these nucleotides with other diseases, their status in controls as well as results of in-silico analysis we proposed the possible pathogenic nature of these variation. (Source: Journal ...
Source: Journal of the Neurological Sciences - September 12, 2019 Category: Neurology Authors: Shalini Mani Tags: Letter to the Editor Source Type: research

Only pathogenic variants in protein-coding mtDNA genes cause Leigh syndrome
With interest we read the article by Mani et al. about 165 patients with thiamin-responsive Leigh syndrome in whom 100 non-synonymous mtDNA variants in protein-coding mtDNA genes were detected [1]. We have the following comments and concerns. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 12, 2019 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research

Factors associated with stigma in community-dwelling stroke survivors in China: A cross-sectional study
Although stigma is considered to be present in stroke patients, the factors that influence its level are ambiguous. The aim of this study was to investigate whether certain demographic, clinical, and psychosocial characteristics are related to higher levels of stigma among stroke patients in China. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 12, 2019 Category: Neurology Authors: CuiYu Deng, Qi Lu, Lili Yang, Rui Wu, Yi Liu, LiYa Li, Shixiang Cheng, Siqi Wei, Yulu Wang, Yaqi Huang, Li Fu, Yue Zhao Source Type: research

The facial nerve atrophy with spinal and bulbar muscular atrophy patients (SBMA): Three case reports with 3D fast imaging employing steady-state acquisition (FIESTA)
Spinal and bulbar muscular atrophy (SBMA) is an X-linked neuromuscular disease caused by a CAG repeat expansion in the androgen receptor (AR) gene [1]. Men afflicted with SBMA develop weakness, atrophy, and fasciculations in the limbs and bulbar muscles during adulthood [2]. In SBMA, facial fasciculations and facial weakness are often prominent. Past SBMA histopathological reports observed that the marked depletion of lower motor neurons (LMNs) through all spinal segments and brainstem motor nuclei – including the facial nerve (FN), but not the third, fourth and sixth cranial nerves – whereas primary sensory ne...
Source: Journal of the Neurological Sciences - September 12, 2019 Category: Neurology Authors: Mari Miyata, Shingo Kakeda, Tomoyo Hashimoto, Yukunori Korogi, Hiroaki Adachi Tags: Letter to the Editor Source Type: research

Deiodinases, organic anion transporter polypeptide polymorphisms and ischemic stroke outcomes
Ischemic stroke is a major cause of premature death and chronic disability worldwide, and individual variation in functional outcome is strongly influenced by genetic factors. Neuroendocrine signaling by the hypothalamic −hypophyseal−thyroid axis is a critical regulator of post-stroke pathogenesis, suggesting that allelic variants in thyroid hormone (TH) signaling can influence stroke outcome.Aim: To examine associations between acute ischemic stroke (AIS) outcome and allelic variants of the TH metabolizing enzy mes deiodinase type 1–3 (DIO1–3) and membrane transporting organic anion polypeptide C1 ...
Source: Journal of the Neurological Sciences - September 11, 2019 Category: Neurology Authors: Saulius Taroza, Daiva Rastenyt ė, Aurelija Podlipskytė, Vaiva Patamsytė, Narseta Mickuvienė Source Type: research

Altered hypothalamic metabolism in early multiple sclerosis – MR spectroscopy study
Multiple sclerosis (MS) is a disease characterized by overlapping processes of neuroinflammation and neuro-axonal degeneration. Disturbances of the hypothalamo-pituitary axis in MS are supposed to modulate neuroinflammatory circuits, however, there is insufficient knowledge about the hypothalamic metabolism alterations in early MS. This 1H MRS study performed on a 1.5  T MR-scanner was focused on the hypothalamus of 31 pre-treatment patients after their first clinical MS episode/s, compared to 31 healthy controls. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 11, 2019 Category: Neurology Authors: P. Hnilicov á, E. Kantorová, H. Poláček, M. Grendár, M. Bittšanský, D. Čierny, Š. Sivák, K. Zeleňák, J. Lehotský, D. Dobrota, E. Kurča Source Type: research

The anterior one third of the posterior limb of the internal capsule is also supplied by the anterior choroidal artery
It is universally recognized that the anterior choroidal artery (AChA) supplies the posterior two-third of the posterior limb of internal capsule (PLIC). On the other hand, the blood supply to the anterior one third of the PLIC has remained undetermined. We posit the anterior one third of the PLIC is also supplied by the AChA referring the previous microsurgical descriptions. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 10, 2019 Category: Neurology Authors: Takashi Koizumi, Yasumasa Yamamoto, Yoshinari Nagakane, Yasuhiro Tomii, Toshiki Mizuno Source Type: research

Invalidation of Parkinson's disease diagnosis after years of follow-up based on clinical, radiological and neurophysiological examination
Diagnosis of Parkinson's disease (PD) is mainly based on clinical features. Accurate neurological examination is required but dopamine transporter (DaT) single photon emission computed tomography (SPECT) could be perfomed to support the diagnosis in ambiguous cases. The aim of this work is to describe the characteristics of patients with a prolonged PD misdiagnosis. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 9, 2019 Category: Neurology Authors: Giulia Coarelli, B éatrice Garcin, Emmanuel Roze, Marie Vidailhet, Bertrand Degos Source Type: research

Cerebral amyloid angiopathy-related transient focal neurological episodes: A transient ischemic attack mimic with an increased risk of intracranial hemorrhage
Transient focal neurological episodes (TFNEs) are a recently recognized clinical presentation of cerebral amyloid angiopathy (CAA). Our aim was to describe the clinical and radiological features of a series of patients with AS. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 7, 2019 Category: Neurology Authors: Marta Vales Montero, Andr és García Pastor, Ana María Iglesias Mohedano, Ester Esteban de Antonio, Paula Salgado Cámara, José Manuel García Domínguez, Pilar Vázquez Alén, Fernando Díaz Otero, Yolanda Fernández Bullido, Antonio Gil Núñez Tags: Clinical short communication Source Type: research

Serial brain MRI changes related to autoimmune pathophysiology in Hashimoto encephalopathy with anti-NAE antibodies: A case-series study
Hashimoto encephalopathy (HE) is an autoimmune-mediated encephalopathy associated with anti-thyroid antibodies. We previously discovered serum autoantibodies against the NH2-terminal of α-enolase (NAE), which serve as a specific diagnostic biomarker for HE and may be involved in the autoimmune pathophysiology of HE, including vasculitis. Although the common findings of brain magnetic resonance imaging (MRI) in HE have been recognized as normal or non-specific white matter lesions, serial MRI changes have been less well studied. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 7, 2019 Category: Neurology Authors: Akiko Matsunaga, Masamichi Ikawa, Yasutaka Kawamura, Toru Kishitani, Osamu Yamamura, Tadanori Hamano, Hirohiko Kimura, Yasunari Nakamoto, Makoto Yoneda Tags: Clinical short communication Source Type: research

Peripheral neuropathy in HIV patients on antiretroviral therapy: Does it impact function?
HIV-associated distal sensory polyneuropathy (DSP), with or without neuropathic symptoms, can develop after anti-retroviral therapy (ART). Symptoms frequently involve small fibres but reports on autonomic dysfunction in HIV-DSP are sparse. We studied an HIV-infected cohort after 5  years of ART, and report on the frequency and severity of autonomic symptoms and the impact of DSP on everyday function. This cross-sectional study comprised of participants from a community-based South African HIV-clinic. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 6, 2019 Category: Neurology Authors: Meagan T. Dudley, Megan Borkum, Wisdom Basera, Nicola Wearne, Jeannine M. Heckmann Source Type: research

Broad spectrum of clinical presentation in EARS2 beyond typical “leukoencephalopathy with thalamus and brain stem involvement”
Mitochondrial diseases comprise a heterogeneous group of disorders due to dysfunction of mitochondrial respiratory chain caused by mutations in both mitochondrial and nuclear genes. EARS2 encodes mitochondrial glutamyl t-RNA synthetase responsible for attaching glutamate to its cognate mitochondrial t-RNA. Hence, EARS2 is critical for protein translation in mitochondria. Homozygous or compound heterozygous EARS2 pathogenic variants are associated with a neurological disorder characterized by leukoencephalopathy with thalamus and brain stem involvement and high lactate (LTBL) [1]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 3, 2019 Category: Neurology Authors: Pankaj Prasun, Cassie Mintz, Emalyn Cork, Thomas P. Naidich, Bryn D. Webb Tags: Letter to the Editor Source Type: research

The association between blood pressure lowering rates and survival time in patients with acute intracerebral hemorrhage
This study was to explore the association between blood pressure lowering rates and survival time in patients with acute ICH. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 3, 2019 Category: Neurology Authors: Fang Yang, Mengzi Sun, Lijuan Wang, Xin Guo, Jing Dou, Li Shen, Liyuan Pu, Chunli Bi, Shuo Li, Yan Yao, Lina Jin Source Type: research