Ischemic stroke in a young woman with anti-phosphatidylserine/prothrombin (aPS/PT) complex antibody: a case report
We report an ischemic stroke patient using an oral contraceptive with aPS/PT complex antibody. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 7, 2018 Category: Neurology Authors: Kenichi Todo, Yasutaka Murakami, Masaya Togo, Tomoyuki Kono, Hajime Yoshimura, Taku Hoshi, Michi Kawamoto, Nobuo Kohara Tags: Letter to the Editor Source Type: research

Response to letter to Editor
We appreciate the comments from Lim and Kaufman on our study titled “The association between restless legs syndrome and premotor symptoms of Parkinson's disease”. Their points are important and we are grateful to have the opportunity for further discussion. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 7, 2018 Category: Neurology Authors: Hirotaka Iwaki, Alberto Ascherio Tags: Letter to the Editor Source Type: research

Methodological considerations for measuring the association between restless legs syndrome and premotor symptoms of Parkinson's disease: An epidemiologic approach
We recently read the article entitled “The association between restless legs syndrome and premotor symptoms of Parkinson's disease” by Iwaki and colleagues [1], published in The Journal of the Neurological Sciences (2018; 394: 41–44). We congratulate the authors for this impressive research, and at the same time offer some further considerations. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 7, 2018 Category: Neurology Authors: Jihoon Lim, Jay S. Kaufman Tags: Letter to the Editor Source Type: research

Computed tomography thorax abnormalities in immunocompetent patients with tuberculous meningitis: An observational study
We aimed to evaluate the imaging abnormalities detected on chest computed tomography (CT) in patients with tuberculous meningitis. CT thorax is imaging modality of choice to demonstrate to detect lesions suggestive of active pulmonary tuberculosis. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 7, 2018 Category: Neurology Authors: Ravi Uniyal, Ravindra Kumar Garg, Hardeep Singh Malhotra, Neeraj Kumar, Amita Jain, Neera Kohli, Sukriti Kumar, Shweta Pandey, Imran Rizvi Source Type: research

Survival and outcome in MELAS not only depends on onset and disease duration
We read with interest the article by Zhang et al. about a retrospective investigation of 138 Chinese MELAS patients, of which 126 carried a mtDNA mutation and of whom 121 underwent face-to-face or telephone follow-up [1]. We have the following comments/concerns. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 7, 2018 Category: Neurology Authors: Josef Finsterer, Sinda Zarrouk-Mahjoub Tags: Letter to the Editor Source Type: research

A case of right orbitofrontal epilepsy featuring ictal swearing
Ictal swearing in focal epilepsy is rare and only a few reports are available. Previous studies have reported a variety of ictal speech automatisms, which frequently have been associated with seizures originating from the temporal lobe [1], and more often in seizures originating from the nondominant hemisphere [2]. However, ictal swearing as a rare phenomenon of speech automatisms, the localizing value and the mechanism underlying ictal swearing have not been well determined. In this article, we present a case with swearing during seizures arising from the right orbitofrontal cortex, confirmed by neuroimaging and stereotac...
Source: Journal of the Neurological Sciences - December 5, 2018 Category: Neurology Authors: Xi Zhang, Guojun Zhang, Kai Ma, Tao Yu, Cuiping Xu, Xiaoming Yan, Wei Du, Yongjie Li Tags: Letter to the Editor Source Type: research

Immediate versus delayed detection of Takotsubo syndrome after epileptic seizures
Takotsubo syndrome(TTS) is often preceded by emotional or physical stress. Epileptic seizures are described in>100 cases. It is unknown whether patients with immediate and delayed detection of seizure-induced TTS differ.We screened the literature and compared clinical and electrocardiographic (ECG) findings. In 48 cases with seizure-associated TTS, the time between seizure and TTS-detection was reported. Troponin levels were elevated in 37/40. ECG abnormalities were negative T-waves(40%), ST-elevations(33%) and ventricular fibrillation/flutter(10%). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 5, 2018 Category: Neurology Authors: Claudia St öllberger, Markus Sauerberg, Josef Finsterer Tags: Review Article Source Type: research

Vestibular dysfunction as cortical damage with amyotrophic lateral sclerosis
Cortical damage in areas such as the frontal lobe is reported in amyotrophic lateral sclerosis (ALS). However, aside from executive dysfunction, the pathological significance of this cortical damage has yet to be clarified. The present study investigated the effects of cortical damage on vestibular function in ALS. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 5, 2018 Category: Neurology Authors: Kiyotaka Nakamagoe, Shiori Yamada, Rio Kawakami, Zenshi Miyake, Naoki Tozaka, Sho Okune, Hayato Takeda, Tadachika Koganezawa, Akira Tamaoka Source Type: research

The association between Parkinson's disease symptom side-of-onset and performance on the MDS-UPDRS scale part IV: Motor complications
Parkinson's disease (PD) is a neurodegenerative condition associated with aging characterized by loss of dopamine-producing neurons in the substantia nigra pars compacta and a reduction in dopamine levels in the striatum. PD is commonly treated using dopamine-replacement medication called levodopa. Levodopa has decreasing efficacy over time. Periods when levodopa is not effective at controlling symptoms of PD are called “OFF-time” or “medication-related motor fluctuations,” (MRMF). One characteristic of PD is unilateral side of symptom onset. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 4, 2018 Category: Neurology Authors: Allison Bay, Ariel Hart, W. Michael Caudle, Daniel M. Corcos, Madeleine Hackney Source Type: research

Electrodiagnostic consultations in Zambia: Referral characteristics and neuromuscular disorders
Research on neuromuscular disorders in sub-Saharan Africa is scarce. We aimed to delineate referral characteristics and the neuromuscular disorders observed among electrodiagnostic (EDX) consultations in a tertiary care setting in Zambia. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 4, 2018 Category: Neurology Authors: Michelle Kvalsund, Patrice Mukomena, Takondwa Chidumayo, Gretchen L. Birbeck, Michael Andary, Michael Horner, David N. Herrmann Source Type: research

A baseline study for detection of Parkinson's disease with 3D-transcranial sonography and uni-lateral reconstruction
This study provides baselines for Parkinson detection (sensitivity and specificity), cutoff values and inter-rater agreement in 3D-TCS. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 3, 2018 Category: Neurology Authors: Annika Plate, Juliana Maiostre, Johannes Levin, Kai B ötzel, Seyed-Ahmad Ahmadi Source Type: research

Incidence, predictors, and outcome of early seizures after mechanical thrombectomy
Despite the wide utilization of mechanical thrombectomy (MT) for acute ischemic stroke treatment, little is known about the incidence of early post-thrombectomy seizures, its predictors, and association with long-term outcome. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 1, 2018 Category: Neurology Authors: Mohammad Anadani, Alain Lekoubou, Eyad Almallouhi, Ali Alawieh, Arindam Chatterjee, Jan Vargas, Alejandro M. Spiotta Source Type: research

The prevalence and prognostic value of myelin oligodendrocyte glycoprotein antibody in adult optic neuritis
This study aimed to investigate the point prevalence, relationship with steroid dependency and prognosis value of MOG-Ab in adult ON. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 28, 2018 Category: Neurology Authors: Hongjuan Liu, Huanfen Zhou, Junqing Wang, Mingming Sun, Da Teng, Honglu Song, Quangang Xu, Shihui Wei Source Type: research

Hemoglobin level and three-month clinical outcomes among ischemic stroke patients with elevated systolic blood pressure
Previous studies have reported that extreme low and high hemoglobin levels are positively associated with the risk of ischemic stroke. However, there are few reports on the relationship between hemoglobin at acute phase and clinical outcomes after ischemic stroke and the results of their association to date are inconsistent. We aimed to investigate the association between them in a large prospective cohort of ischemic stroke patients. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 27, 2018 Category: Neurology Authors: Daoxia Guo, Zhengbao Zhu, Chongke Zhong, Hao Peng, Tian Xu, Aili Wang, Yanbo Peng, Tan Xu, Chung-Shiuan Chen, Yongqiu Li, Zhong Ju, Jing Chen, Yonghong Zhang, Jiang He Source Type: research

Current practice patterns in CIDP: A cross-sectional survey of neurologists in the United States
To evaluate how neurologists make decisions regarding chronic inflammatory demyelinating polyneuropathy (CIDP), we conducted a cross-sectional quantitative survey of 100 community neurologists in the United States. Only 13% cited using the European Federation of Neurological Societies/Peripheral Nerve Society guideline. In addition, variability in treatment approaches existed regarding the dose of IVIg used, the length of IVIg therapy before determining response, the outcome measures used to determine IVIg response, and the protocol for weaning off therapy. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 27, 2018 Category: Neurology Authors: Deborah Gelinas, Jonathan Katz, Paul Nisbet, John D. England Source Type: research

Hypodensities detected at 1.5 –3 h after intracerebral hemorrhage better predicts secondary neurological deterioration
Secondary neurological deterioration in patients with spontaneous intracerebral hemorrhage (sICH) develops within the first 24 or 48  h after ICH onset and appears to portend a poor prognosis. We aimed to verify whether hypodensities within an acute ICH detected by noncontrast computed tomography (NCCT) were able to predict secondary neurological deterioration and investigate which monitoring window was of the highest predictiv e value. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 27, 2018 Category: Neurology Authors: Jing Dong, Xiaobo Yang, Jun Xiang, Qiang Dong, Yuping Tang, Heling Chu Source Type: research

Whole transcriptome sequencing analyses of DHA treated glioblastoma cells
Glioblastoma (GBM) is a typical malignant tumor, and there are no effective drugs capable of improving patient survival. Docosahexaenoic acid (DHA), a nutrient essential to animal health and neurodevelopment, exerts an anticancer effect in several types of cancer. However, the function of DHA in GBM is still unclear. Here, we showed that DHA could repress the migration and invasion of GBM U251 cells and promote their apoptosis in a dose- and time-dependent manner, indicating that DHA has an anticancer effect on GBM cells. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 22, 2018 Category: Neurology Authors: Miaomiao Ruan, Jiying Liu, Xueyang Ren, Chu Li, Allan Z. Zhao, Lin Li, Haiyuan Yang, Yifan Dai, Ying Wang Source Type: research

Medication status and dual-tasking on turning strategies in Parkinson disease
Parkinson disease (PD) patients have turning impairments that may increase fall risk. Clinics lack specialized kinematic equipment used in gait and turn analysis and require a simple method to evaluate fall risk and advise patients in turning strategy selection. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 22, 2018 Category: Neurology Authors: M.B. Adamson, G. Gilmore, T.W. Stratton, N. Baktash, M.S. Jog Source Type: research

Central nervous system involvement in patients with critical illness polyneuropathy
Critical illness polyneuropathy (CIP) is a common complication of severe critical illness that presents with limb and respiratory muscle weakness. The deep tendon reflex (DTR) is diminished or absent in severe forms of CIP. Herein we discuss two patients with CIP showing exaggerated DTRs. The diagnosis of CIP was based on the presence of primary axonal degeneration in sensory-motor neuropathy without any evidence of inflammation or demyelination in the electrophysiological or histopathological findings [1,2]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 21, 2018 Category: Neurology Authors: Aki Murayama, Keizo Sugaya, Toshio Shimizu, Yoko Sunami, Shinsuke Tobisawa, Eiji Isozaki Tags: Letter to the Editor Source Type: research

A recurrent de-novo ANO3 mutation causes early-onset generalized dystonia
Anoctamin 3 (ANO3) mutations have first been reported in families with autosomal dominant cervical, laryngeal and/or upper-limb tremulous dystonia in 2012 [1]. Since then a number of studies have described rare ANO3 variants in dystonia patients often with inconclusive segregation in available family members [2,3]. Notably, rare ANO3 missense variants could also be detected in 0.3 –0.5% of presumably healthy individuals [4]. Thus, the pathogeneity of ANO3 variants in dystonia is still under debate [5]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 21, 2018 Category: Neurology Authors: Sinem Tunc, Jonas Denecke, Luisa Olschewski, Tobias B äumer, Alexander Münchau, Davor Lessel, Katja Lohmann Tags: Letter to the Editor Source Type: research

Targeting optimal time for hyperbaric oxygen therapy following carbon monoxide poisoning for prevention of delayed neuropsychiatric sequelae: A retrospective study
Delayed neuropsychiatric sequelae (DNS) are serious complications of carbon monoxide poisoning; neuropsychiatric disorders can occur within a few days of recovery from acute poisoning. Hyperbaric oxygen therapy (HBOT) has been the main treatment of carbon monoxide (CO) poisoning and was recommended as the treatment choice for CO poisoning by the American Undersea and Hyperbaric Medical Society and the Tenth European Consensus Conference on Hyperbaric Medicine of the European Underwater and Baromedical Society. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 21, 2018 Category: Neurology Authors: Shu-Chen Liao, Yan-Chiao Mao, Kun-Ju Yang, Kuo-Cheng Wang, Li-Ying Wu, Chen-Chang Yang Source Type: research

Natalizumab exposure during pregnancy in multiple sclerosis: a systematic review
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system typically affecting young adults. The median onset age of MS is around 30  years which is the childbearing years for many women. Thus, pregnancy is a significant concern for many of them. Although studies suggested that pregnancy played a protective role for MS since disease activity was generally reduced during pregnancy [28]. For those with high disease activity, preg nancy is still a big challenge. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 21, 2018 Category: Neurology Authors: Anjiao Peng, Xiangmiao Qiu, Lin Zhang, Xi Zhu, Shixu He, Wanlin Lai, Lei Chen Tags: Review Article Source Type: research

Mechanical thrombectomy outcomes in large vessel stroke with high international normalized ratio
Evaluating the safety and efficacy of mechanical thrombectomy (MT) in acute stroke patients due to emergent large vessel occlusion (ELVO) with high international-normalized-ratio (INR). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 19, 2018 Category: Neurology Authors: Abhi Pandhi, Georgios Tsivgoulis, Muhammad F. Ishfaq, Aristeidis Katsanos, Georgios Magoufis, Konark Malhotra, Rashi Krishnan, Adam Arthur, Daniel Hoit, Lucas Elijovich, Andrei V. Alexandrov, Ahmad Cheema, Nitin Goyal Source Type: research

Mollaret meningitis
Mollaret's meningitis is a rare complication of Herpes simplex virus, type-2 infection (HSV-2) [1]. The most common presentation is characterized by attacks of sudden onset aseptic (viral) meningitis followed by complete recovery and unpredictable recurrences [2]. In addition to symptoms typical of meningitis, patients may also have transient hallucinations, seizures, cranial nerve palsies, or altered level of consciousness. Acyclovir is an acrylic purine nucleoside analog that inhibits the herpesvirus DNA polymerase of herpes simplex virus types 1 and 2 (HSV-1, HSV-2). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 17, 2018 Category: Neurology Authors: William F. Wright, Kathryn Palisoc, Salim Baghli Tags: Letter to the Editor Source Type: research

Vitamin D supplementation has no effect on cognitive performance after four months in mid-aged and older subjects
Low serum 25-hydroxyvitamin D (25(OH)D) levels are associated with impaired cognitive function, but the effect of vitamin D supplementation on cognitive function is uncertain. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 17, 2018 Category: Neurology Authors: Rolf Jorde, Julia Kubiak, Johan Svartberg, Ole M. Fuskev åg, Yngve Figenschau, Ieva Martinaityte, Guri Grimnes Source Type: research

The comparative study of island sign and the spot sign in predicting short-term prognosis of patients with intracerebral hemorrhage
Objectives: It is well known that early hematoma expansion is associated with short-term prognosis of patients with intracranial hemorrhage (ICH). And spot sign is recognized as a reliable computed tomography angiography (CTA) predictor for early hematoma expansion. Recently, island sign is also reported as a novel computed tomography (CT) predictor for early hematoma growth. Here, we compared the predictive abilities of these two signs for short-term outcomes of ICH patients.Patients and Methods: All the ICH patients were retrospectively identified. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 17, 2018 Category: Neurology Authors: F. Zhang, S. Zhang, C. Tao, Z. Yang, C. You, M. Yang Source Type: research

Corticosteroid-dependent tuberculous meningitis: A case report
The effectiveness of adjunctive corticosteroids for treating tuberculous meningitis has been established in patients without HIV infection [1], and previous reviews have recommended some treatment regimens [2,3]; however, the optimum dosage remains unclear. Here, we present a case of tuberculous meningitis, wherein symptoms worsened with each reduction of corticosteroid administration, necessitating prolonged adjunctive use of high-dose corticosteroids. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 17, 2018 Category: Neurology Authors: Akira Machida, Eiichiro Amano, Shinichi Otsu, Shinobu Akagawa Tags: Letter to the Editor Source Type: research

Estimated glomerular filtration rate predicts incident stroke among Ghanaians with diabetes and hypertension
This study sought to fill this knowledge gap. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 15, 2018 Category: Neurology Authors: Fred Stephen Sarfo, Linda Meta Mobula, Osei Sarfo-Kantanka, Sheila Adamu, Jacob Plange-Rhule, Daniel Ansong, Rexford Adu Gyamfi, James Duah, Bertha Abraham, David Ofori-Adjei Tags: Clinical short communication Source Type: research

AQP4 antibody-positive NMO spectrum disorder associated with Takayasu arteritis
Neuromyelitis optica spectrum disorder (NMOsd) is an aggressive autoimmune condition characterized by optic neuritis and longitudinally extensive transverse myelitis (LETM) [1]. Specific autoantibodies directed against aquaporine 4 (anti-AQP4) are present in more than 70% of the cases [2]. Association with various other systemic autoimmune diseases have been reported, mostly systemic lupus erythematosus and Sj ögren's syndrome [3]. Takayasu arteritis is a rare large-vessel vasculitis in which granulomatous inflammation involves mainly the aortic arch and its branches. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 13, 2018 Category: Neurology Authors: M. Lamartine S. Monteiro, A.M. Lascano, N. Meunier Carus Vincent, J.D. Seebach, P. Lalive, M. Gschwind Tags: Letter to the Editor Source Type: research

A new Italian family with HTRA1 mutation associated with autosomal-dominant variant of CARASIL: Are we pointing towards a disease spectrum?
Cerebral small vessel disease (SVD) is recognized to be the leading cause of vascular dementia. Although the most cases are sporadic, familial monogenic causes have been identified. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), a recessive form of heritable SVD, is caused by a mutation in the HtrA serine peptidase 1 (HTRA1) gene, and characterized by progressive neurological deterioration along with early baldness and severe spondylosis [1]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 10, 2018 Category: Neurology Authors: Silvia Favaretto, Monica Margoni, Leonardo Salviati, Luigi Pianese, Renzo Manara, Claudio Baracchini Tags: Letter to the Editor Source Type: research

Treatment of intractable resting tremor of spinocerebellar ataxia 42 with zonisamide
Zonisamide (ZNS) was originally developed as an antiepileptic drug and is a T-type calcium (Ca) channel inhibitor. A previous clinical trial found that ZNS shortened the duration of “off” time in patients with Parkinson's disease [1]. ZNS is also effective in resting tremor in patients with Parkinson's disease in which dopamine is not effective [2]. Moreover, ZNS was useful for the treatment of essential tremor. Several basic research studies have reported that other T-type Ca channel blockers were effective in treating experimental tremors [3]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 10, 2018 Category: Neurology Authors: Naoyuki Hara, Tomohisa Nezu, Keitaro Kobatake, Hiroyuki Morino, Hideshi Kawakami, Hirofumi Maruyama Tags: Letter to the Editor Source Type: research

Cerebral folate deficiency in adults: A heterogeneous potentially treatable condition
To describe the phenotype and the response to folinic acid supplementation of cerebral folate deficiency (CFD) in adults, a disorder diagnosed on low 5-methyltetrahydro-folate (5MTHF) in cerebrospinal fluid (CSF), which can correspond to a inherited disorder of folate metabolism (IDFM) or to a metabolic consequence of various neurological diseases. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 10, 2018 Category: Neurology Authors: Marion Masingue, Jean-Fran çois Benoist, Emmanuel Roze, Fathi Moussa, Frédéric Sedel, Catherine Lubetzki, Yann Nadjar Source Type: research

Supplementary motor area connectivity and dual-task walking variability in multiple sclerosis
The objective of this study was to examine relationships between neuroimaging measures and clinical measures of dual-task performance, and reported falls in persons with MS. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 10, 2018 Category: Neurology Authors: Nora E. Fritz, Anne D. Kloos, Deborah A. Kegelmeyer, Parminder Kaur, Deborah S. Nichols-Larsen Source Type: research

Vertebral artery loop in a case of recurrent transient global amnesia
Transient global amnesia (TGA) denotes a temporary anterograde amnesia and a mild reduction of retrograde episodic memory, while immediate recall ability is preserved. TGA is of sudden onset, lasts about 4 –6 h, and typically no focal neurological findings are appreciated on the clinical exam. The medial temporal lobe supplied by the posterior cerebral circulation has been identified as the affected anatomical correlate, however, pathophysiology remains elusive [1]. A broad spectrum of conditions may trigger TGA, including emotional stress, migraine, or physical effort. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 9, 2018 Category: Neurology Authors: Philipp Karschnia, Robert K. Fulbright, Joachim M. Baehring Tags: Letter to the Editor Source Type: research

Plasma β-amyloid1–42 reference values
Zecca et al. evaluated plasma β-Amyloid1–42 (Aβ1–42) concentrations in 245 cognitively normal subjects to determine reference values of Alzheimer's disease. [1]. The mean concentration of plasma Aβ1–42 increased by aging, although there was no significant difference in the mean concentration of plasma Aβ1–42 between the adult (35 to 64 years old) and the old (65 to 89 years old) groups. The authors presented 8.12 (95% CI 6.77–9.45) to 29.00 (95% CI 27.01–31.00) pg/mL as a reference value from the lower to upper limit. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 9, 2018 Category: Neurology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research

Response to Letter to the Editor: “Plasma β-amyloid1–42 reference values”
We thank Dr. Kawada for the interest for our work and the thorough observations [1]. We are pleased to provide further comments to the main conclusions provided by Dr. Kawada that validation study on cutoff value should be conducted by further studies. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 9, 2018 Category: Neurology Authors: Chiara Zecca, Vincenzo Brescia, Francesco Panza, Giancarlo Logroscino Tags: Letter to the Editor Source Type: research

Acute reaction of arterial blood vessels after experimental subarachnoid hemorrhage – An in vivo microscopic study
This study was conducted to visualize and investigate immediate vascular reactions during and after experimental SAH. Male Sprague-Dawley rats were subjected to SAH by the endovascular filament model (n  = 7) or served as controls (n = 4). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 8, 2018 Category: Neurology Authors: Thomas Westermaier, Christian Stetter, Diana Koehler, Judith Weiland, Nadine Lilla Source Type: research

Long –Standing evolution of paraneoplastic cerebellar degeneration in a diffuse large B-cell lymphoma
Paraneoplastic cerebellar degeneration (PCD) is characterized by pancerebellar ataxia with diplopia, nystagmus and dysarthria that might evolve subacutely or over months to years [1 –8]. Blurred vision and oscillopsia typically occur early in the disease, often preceding the manifestations of the primary malignancy [1–8]. Malignancies most commonly associated with PCD include gynecologic, breast, small cell lung cancers, Hodgkin's lymphoma [1–8]. The combination of tumour s and neurologic disability suggests the occurrence of effective antitumour autoimmunity, especially in cases with associated antibodie...
Source: Journal of the Neurological Sciences - November 8, 2018 Category: Neurology Authors: Giuliana Galassi, Maurilio Genovese, Fabio Forghieri, Alessandra Ariatti, Marcella Malagoli, Alessandra Melegari, Antonio Maiorana Tags: Letter to the Editor Source Type: research

Concurrent Guillain-Barr é syndrome, transverse myelitis and encephalitis post-Zika: A case report and review of the pathogenic role of multiple arboviral immunity
We thank Yasri and Wiwanitkit for their comments on our review article of Zika virus (ZIKV) neurotropism [1,2]. They indicate that in their geographic region in South East Asia (Thailand) —a ZIKV endemic area— the concurrent immunoreactivity to ZIKV and other arboviruses is very common, particularly with dengue virus (DENV) and Chikungunya virus (CHIKV) [3], but there are no reports of neurological complications resulting from co-reactivity between ZIKV and other arboviruses. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 5, 2018 Category: Neurology Authors: Gustavo C. Rom án, Juan-Manuel Anaya, Óscar Mancera-Páez, Rodrigo Pardo-Turriago, Yohan Rodríguez Tags: Letter to the Editor Source Type: research

Hydrogen as a complementary therapy against ischemic stroke: A review of the evidence
Ischemic stroke is one of the most common sources of mortality in the world. Researchers have been trying to find a complementary therapy to treat ischemic stroke in order to improve its prognosis and expand the therapeutic window for reperfusion treatment. For this reason, many experimental and clinical trials studying the effects of hydrogen against ischemic stroke have been published. Hydrogen gas has been found to eliminate hydroxyl free radical and peroxynitrite anions as well as producing therapeutic effect in patients with ischemic stroke. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 5, 2018 Category: Neurology Authors: He Li, Yin Luo, Pengfei Yang, Jianmin Liu Tags: Review Article Source Type: research

Effect of istradefylline on mood disorders in Parkinson's disease
In this study, the effectiveness of istradefylline for treatment of mood disorders in patients with PD was examined in an open-label trial. Thirty PD patients were enrolled. All patients had scores of higher than cut-off level in at least one of the following batteries: Snaith-Hamilton Pleasure Scale Japanese version (SHAPS-J), Apathy scale, or Beck Depression Inventory-2nd edition (BDI). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 5, 2018 Category: Neurology Authors: Hiroshi Nagayama, Osamu Kano, Hidetomo Murakami, Kenjiro Ono, Masashi Hamada, Tatsushi Toda, Renpei Sengoku, Yasushi Shimo, Nobutaka Hattori Source Type: research

Decreased fractal dimension of heart rate variability is associated with early neurological deterioration and recurrent ischemic stroke after acute ischemic stroke
Acute ischemic stroke (AIS) may experience early neurological deterioration (END) and have high risks of recurrent ischemic strokes (RIS), which are often associated with a poor outcome. Post-stroke prognosis is associated with autonomic status. Recently, studies showed that heart rate variability (HRV) is an early outcome predictor in acute stroke patients. The purpose of our study was to investigate association decreased HRV by fractal dimension (FD) with early END within 72  h of admission and 1-year RIS. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 5, 2018 Category: Neurology Authors: Lanying He, Jian Wang, Lili Zhang, Xiaoqiang Zhang, Weiwei Dong, Hao Yang Source Type: research

Adult CSF total protein: Higher upper reference limits should be considered worldwide. A web-based survey
The cerebrospinal fluid total protein level (CSF-TP) is commonly used as a potential marker of infectious or immune disease of the CNS and PNS. Recent laboratory reference studies indicate that the antiquated single upper reference limit of 0.45  g/L commonly used by hospital laboratories and widely quoted in medical literature is a significant underestimation. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 2, 2018 Category: Neurology Authors: Pierre R. Bourque, Ari Breiner, David Moher, John Brooks, Harald Hegen, Florian Deisenhammer, Chris McCudden Source Type: research

EBV-NMDA double positive encephalitis in an immunocompromised patient
In the past years rare cases of double positive Epstein-Barr virus (EBV) and anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis in post solid organ transplant (SOT) patients, were reported [1 –3]. We highlight the fact that clinicians should consider autoimmune encephalitis in SOT patients despite treatment with immunosuppressants and would like to highlight the good outcome in this case with antiviral treatment and adjusted immunotherapy. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 2, 2018 Category: Neurology Authors: Garr é Jinte, Sprengers Mathieu, Van Melkebeke Deborah, Laureys Guy Tags: Letter to the Editor Source Type: research

Influence of the circle of Willis on leptomeningeal collateral flow in anterior circulation occlusive stroke: Friend or foe?
Clinical outcome after large vessel occlusion (LVO) stroke depends on collateral integrity. We aimed to evaluate whether the completeness of the circle of Willis (CoW) and anterior temporal artery (ATA) determines the status of leptomeningeal collaterals (LC) in patients with acute LVO (internal carotid artery (ICA) and middle cerebral artery M1 (MCA) occlusion) treated with endovascular thrombectomy. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 2, 2018 Category: Neurology Authors: Katarina Millesi, Johannes Sebastian Mutzenbach, Monika Killer-Oberpfalzer, Constantin Hecker, Lukas Machegger, Nele Bubel, Christian Ramesmayer, Slaven Pikija Source Type: research

Low levels of alpha-synuclein in peripheral tissues are related to clinical relapse in relapsing-remitting multiple sclerosis: A pilot cross-sectional study
The protein alpha-synuclein ( α-Syn) has been linked to neuroinflammatory conditions. We investigated whether the presence of α-Syn in peripheral tissues is a surrogate of brain inflammatory status in a small group of relapsing-remitting multiple sclerosis (RRMS) patients in a pilot cross-sectional study. Skin biopsies and per ipheral blood were sampled from 34 healthy controls and 23 MS patients for measurement of α-Syn levels. Within the RRMS group 15 patients were in remission, and 8 patients were in the relapsing phase. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 2, 2018 Category: Neurology Authors: Manuel Mej ía, Ildefonso Rodríguez-Leyva, Fernando Cortés-Enríquez, Erika Chi-Ahumada, Diana Patricia Portales Pérez, Miguel Angel Macías-Islas, María E. Jiménez-Capdeville Source Type: research

Opsoclonus-myoclonus-encephalopathy induced by cefepime
Cefepime is an intravenous broad-spectrum cephalosporin widely used in clinical practice. Cephalosporins might produce reversible neurotoxicity due to gamma-aminobutyric acid (GABA) receptor antagonism [1], particularly when administered during renal dysfunction [2,3]. Cefepime-induced neurotoxicity is associated with myoclonus and other hyperkinetic movements, seizures and non-convulsive status epilepticus (NCSE), with concomitant mental status changes ranging from mild encephalopathy to coma [2,3]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 1, 2018 Category: Neurology Authors: Karlo J. Lizarraga, Deborah O. Heros, David Adams, Anthony E. Lang, Andres M. Kanner Tags: Letter to the Editor Source Type: research

Guillain Barr é syndrome in arbovirus outbreak, Campylobacter claims his throne
In the present short communication, we make of your knowledge results obtained from the investigation of Guillain Barr é syndrome in Mexico, since 2016, where we have found interesting data, such as a very low incidence of Zika as responsible for the syndrome and in counterpart the presence of campilobacter, one of the main agents known in the pre- Zika era. In addition, other neurotropic viruses have been found, s o this experience recommends a protocol of causative agents that includes viruses and bacteria with neurotropic potential. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 1, 2018 Category: Neurology Authors: Luis del Carpio-Orantes, Karla Gabriela Peniche Moguel, Jesus Salvador S ánchez Díaz, Maria del Rosario Pola-Ramirez, Maria del Pilar Mata Miranda, Sergio García-Méndez, Miguel Arnulfo Perfecto-Arroyo, Ishar Solís-Sánchez Tags: Clinical short communication Source Type: research

Editorial for adult CSF total protein: Higher upper reference limits should be considered worldwide. A web-based survey
The cerebrospinal fluid total protein level is commonly used as an indicator or marker of several diseases of the peripheral - (PNS) and central nervous system (CNS). Worldwide most laboratories use the upper reference limit of 0.45  g/L for CSF protein. Based on own investigations and a global survey the authors of this paper research the worldwide upper reference limits [1]. The overarching question was, if this upper limit was a fixed level, or subject to age related changes. This investigation refers to CSF usually obtain ed by lumbar puncture and does not consider the ventricular CSF [2], nor children [3]. (Source: ...
Source: Journal of the Neurological Sciences - November 1, 2018 Category: Neurology Authors: Wolfgang Grisold Tags: Editorial Source Type: research

Concurrent Guillain-Barr é syndrome, transverse myelitis and encephalitis post-Zika and multiple arboviral immunity
Dear Editor, we read the clinical case report by et al. on “Concurrent Guillain-Barré syndrome (GBS), transverse myelitis and encephalitis post-Zika and multiple arboviral immunity [1]” with a great interest and would like to share ideas and experience on this problem. Mancera-Páez et al. concluded that the clinical problem is induced by acute Zika vi rus (ZIKV) neurotropism boosted by active immunity against other arboviruses [1]. Indeed, the concurrence is possible and might be directly due to Zika virus or might be the result of concurrent Zika virus infection and other medical disorders that c...
Source: Journal of the Neurological Sciences - November 1, 2018 Category: Neurology Authors: Sora Yasri, Viroj Wiwanitkit Tags: Letter to the Editor Source Type: research