Distinction between anti-VGKC-complex seropositive patients with and without anti-LGI1/CASPR2 antibodies
To identify clinical and paraclinical differences between anti-voltage-gated potassium channel (VGKC)-complex seropositive patients with and without anti-leucine-rich glioma-inactivated protein 1 (LGI1)/contactin-associated protein-like 2 (CASPR2) antibodies (Abs). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 27, 2018 Category: Neurology Authors: Tianrong Yeo, Zhiyong Chen, Kok Pin Yong, Patricia Yut Wan Wong, Josiah Yui Huei Chai, Kevin Tan Source Type: research

Monitoring of structural changes in the course of acute compressive radial neuropathies by means of high resolution nerve ultrasound
High resolution nerve ultrasound (HRNUS) is an increasingly used diagnostic tool and has been studied extensively in the last years and has contributed significantly to the understanding of peripheral nerve pathologies [1]. High resolution images of modern ultrasound systems yield additional structural information about vessels, muscles, ligaments, bones and nerves to usual functional electroneurographical examinations [1]. Thus, HRNUS provides helpful diagnostic information about the underlying disease in case of secondary entrapment syndromes (intraneural ganglia, nerve tumors etc.) [2,3]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 26, 2018 Category: Neurology Authors: Jeremias Motte, Ralf Gold, Christos Krogias Tags: Letter to the Editor Source Type: research

Formaldehyde, DNA damage, ALS and related neurodegenerative diseases
Carmel Armon argues that causation of disease can be inferred by application of classical methods of epidemiological inference, and he draws on information gleaned from experience with familial, sporadic and Western Pacific forms of ALS. He concludes that disease in all cases begins with DNA damage in single neurons, probably Betz cells, from which it spreads through the neuronal network by an undefined mechanism. By analogy, he draws on the methods of John Snow, who identified the source of London's 1854 cholera epidemic and, in the 20th century, on Richard Doll and Bradford Hill's reasoning that linked cigarette smoking ...
Source: Journal of the Neurological Sciences - May 24, 2018 Category: Neurology Authors: Peter S. Spencer Tags: Editorial Source Type: research

Evaluation of the use of the Scale for the Assessment and Rating of Ataxia (SARA) in healthy volunteers and patients with schizophrenia
The Scale for the Assessment and Rating of Ataxia (SARA) is a semi-quantitative assessment used to evaluate ataxia. The goal of these studies was to assess and evaluate the utility of this instrument in a Healthy Volunteer (HV) group and subjects with Schizophrenia (SCZ). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 23, 2018 Category: Neurology Authors: Nina Shaafi Kabiri, Sana Syed, Taha Bali, Daniel R. Karlin, Brendon Binneman, Ye Tan, Alexii Steinman, Alanna C. Cote, Kevin C. Thomas Source Type: research

Deep brain stimulation is effective in pediatric patients with GNAO1 associated severe hyperkinesia
Exacerbation of hyperkinesia is a life-threatening complication of dyskinetic movement disorders, which can lead to multi-organ failure and even to death. The guanine nucleotide-binding protein (GNAO1) has been recently identified to be involved in the pathogenesis of early infantile epileptic encephalopathy and movement disorders. Patients with GNAO1 mutations may present with a severe, progressive hyperkinetic movement disorder with prolonged life-threatening exacerbations, which are refractory to most anti-dystonic medication. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 22, 2018 Category: Neurology Authors: Anne Koy, Sebahattin Cirak, Victoria Gonzalez, Kerstin Becker, Thomas Roujeau, Christophe Milesi, Julien Baleine, Gilles Cambonie, Alain Boularan, Frederic Greco, Pierre-Francois Perrigault, Claude Cances, Nathalie Dorison, Diane Doummar, Agathe Roubertie Source Type: research

Domain-specific characterisation of early cognitive impairment following spontaneous intracerebral haemorrhage
This study aims to describe the cognitive profile following acute ICH and explore how cerebral amyloid angiopathy (CAA) may impact performance. We retrospectively reviewed 187 consecutive patients with ICH (mean age 58.9  years, 55.6% male) with available imaging and neuropsychological data (median 12 days after stroke). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 21, 2018 Category: Neurology Authors: Gargi Banerjee, Mary Summers, Edgar Chan, Duncan Wilson, Andreas Charidimou, Lisa Cipolotti, David J. Werring Source Type: research

From snow to hill to ALS: An epidemiological odyssey in search of ALS causation
Establishing mechanisms of disease causation in neurodegenerative diseases has long seemed to be beyond the pale of traditional epidemiological tools. Establishing a plausible mechanism for initiation of amyotrophic lateral sclerosis (ALS) has appeared a particularly elusive goal. This review shows that a likely mechanism for ALS initiation may be inferred by applying classical methods of epidemiological inference. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 21, 2018 Category: Neurology Authors: Carmel Armon Tags: Review Article Source Type: research

Neurocardiac prodrome in LGI1-antibody-negative non-paraneoplastic limbic encephalitis
We present the case of a 36-year-old woman with a LGI1-antibody-negative limbic encephalitis who experienced frequent episodic asystole with syncope three months before onset of the typical presentation of LE. Recently, such a neurocardiac prodrome was reported as a novel distinctive prodrome of LGI1-antibody-positive encephalitis [1,2]. This is the first description of a neurocardiac prodrome in a LGI1-antibody-negative LE. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 18, 2018 Category: Neurology Authors: Tobias Kaluschke, Wibke Johannis, Anastasios Mpotsaris, Gereon R. Fink, Michael P. Malter Tags: Letter to the Editor Source Type: research

Fatal ischemic stroke caused by cerebral small arteritis in a patient with giant cell arteritis
Giant cell arteritis (GCA) is characterized by autoimmune vasculitis involving large and medium-sized vessels [1,2]. Ischemic stroke is seen in 2.8 –7% of patients with GCA, and the prognosis of GCA patients after developing ischemic stroke is unfavorable, especially in patients with involvement of intracranial large arteries [1,3,4]. Here, we describe an autopsy case of GCA in which the patient presented with ischemic stroke related to multi ple intracranial large-artery stenoses, and ultimately fatal ischemic stroke. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 17, 2018 Category: Neurology Authors: Fumi Nakano, Yuji Ueno, Akimitsu Suda, Masashi Takanashi, Atsushi Yamashita, Yoshiyuki Abe, Takayuki Kon, Nobukazu Miyamoto, Kazuo Yamashiro, Ryota Tanaka, Toshio Naito, Takashi Yao, Naoto Tamura, Nobutaka Hattori Tags: Letter to the Editor Source Type: research

Fluctuating CSF hypocretin-1 levels in mild brain trauma-induced Kleine-Levin syndrome
Kleine-Levin syndrome (KLS) is a rare sleep disorder, mainly affecting adolescent boys, and is characterized by recurrent hypersomnia combined with cognitive, mood, and/or behavioral disturbances [1]. It typically follows various precipitating factors such as infection, alcohol-drinking, and mental and physical stress [1]. Although the precise pathophysiology of KLS remains unclear, several functional neuroimaging studies have shown hypoperfusion in the hypothalamus, thalamus, caudate nucleus, and associative cortical areas during symptomatic and/or asymptomatic periods in patients with KLS [2]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 17, 2018 Category: Neurology Authors: Maho Usuda, Minori Kodaira, Yuka Ogawa, Takashi Kanbayashi, Shin Yanagisawa, Yoshiki Sekijima Tags: Letter to the Editor Source Type: research

Zonisamide cotreatment delays striatal dopamine transporter reduction in Parkinson disease: A retrospective, observational cohort study
This study examined whether zonisamide (ZNS) cotreatment delays dopamine transporter (DAT) reduction on SPECT in Parkinson disease (PD) patients. The study participants met the following criteria: (i) age  ≥ 40 years; (ii) HY stage = 2 or 3; (iii) average specific binding ratio (SBR) ≥2.00; (iv) levodopa administration without a prior history of ZNS use before the first DAT-SPECT (baseline). Attending physicians initially determined whether ZNS (25 mg/day) should be used or not. Levod opa and other anti-PD medications were not restricted. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 17, 2018 Category: Neurology Authors: Ken Ikeda, Masaru Yanagihashi, Ken Miura, Yuichi Ishikawa, Takehisa Hirayama, Takanori Takazawa, Osamu Kano, Kiyokazu Kawabe, Nao Mizumura, Yasuo Iwasaki Source Type: research

Correlation between clinical and radiologic features of patients with Gerstmann-Str äussler-Scheinker syndrome (Pro102Leu)
This study is aim to demonstrate the clinical spectrum and radiologic characteristics of patients caused by Pro102Leu mutation in PRNP. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 17, 2018 Category: Neurology Authors: Michiyoshi Yoshimura, Jun-Hui Yuan, Keiko Higashi, Akiko Yoshimura, Hitoshi Arata, Ryuichi Okubo, Yoshiaki Nakabeppu, Takashi Yoshiura, Hiroshi Takashima Source Type: research

Reversible sensory polyneuropathy during an arboviral outbreak in Salvador, Bahia, Brazil
Guillain-Barr é syndrome (GBS), an acute, immune- mediated polyradiculoneuropathy, typically occurs in response to minor viral and bacterial infections. Associations between this syndrome and previous arboviral infection, such as dengue (DENV), chikungunya (CHIKV) or Zika virus (ZIKV), have been reported in some studies [1,2]. GBS usually manifests as generalized weakness and areflexia, accompanied by sensory and autonomic disturbances [3]. Mild neurologic syndromes associated with ZIKV infection have previously been described, characterized by short-term isolated sensory disturbances [4,5]. (Source: Journal of the ...
Source: Journal of the Neurological Sciences - May 12, 2018 Category: Neurology Authors: Mateus Santana do Ros ário, Pedro Antônio Pereira de Jesus, Daniel Santana Farias, Marco Antônio Caires Novaes, Cleiton Silva Santos, Sasha R. Azar, Nikos Vasilakis, Daniel Lima de Moura, Fernanda Washington de M. Lima, Luiz Carlos Junior Alcantara, Is Tags: Letter to the Editor Source Type: research

Corrigendum to “Guillain-Barre syndrome and the clinical importance of a early diagnosis for a better prognosis” [J. Neurol. Sci. 357S (2015) e452–e453]
The authors regret that in the initial publication the author name G.B. Cruz was incorrectly displayed, this should read G.B. Teixeira. The affiliation of G.B. Teixeira was also incorrectly displayed, this should read “Medicine, Unievangélica, Anápolis, Brazil”. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 11, 2018 Category: Neurology Authors: R.V.B. Caldeira, Y.C. Machado, M.C. Mota, T.B. Machado, N.C.M. Queiroz, M.C.N. Pires, I.S. Teixeira, I.H.L. Rocha, G.B. Teixeira, R.P.S. Filho, B. Gomes Mazzoni Tags: Corrigendum Source Type: research

Meningitis-retention syndrome: Clinical features, frequency and prognosis
Meningitis-retention syndrome (MRS) is a peculiar combination of aseptic meningitis (AM) and acute urinary retention without other neurological symptoms. MRS has not been well recognised, and the prevalence of MRS in patients with AM is unknown. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 10, 2018 Category: Neurology Authors: Akiyuki Hiraga, Satoshi Kuwabara Source Type: research

Lower limb apraxia in corticobasal syndrome
Corticobasal syndrome (CBS) is a rare, mostly sporadic, progressive neurodegenerative syndrome characterizes by asymmetrical parkinsonism with a variable combination of rigidity, dystonia, myoclonus, apraxia, alien limb phenomena, and cortical sensory defecit [1,2]. Corticobasal degeneration (CBD) remains a hitopathological diagnosis and CBS, originally defined as a clinical feature of CBD, is being used to diagnose neurodegenerative syndrome. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 7, 2018 Category: Neurology Authors: Hyun Ah. Kim, Sohyeon Kim, Sooyeoun You Tags: Letter to the Editor Source Type: research

Reduced gray matter volume is correlated with frontal cognitive and behavioral impairments in Parkinson's disease
To identify the brain-volume reductions associated with frontal cognitive and behavioral impairments in Parkinson's disease (PD). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 7, 2018 Category: Neurology Authors: Tatsuhiro Terada, Jun Miyata, Tomokazu Obi, Manabu Kubota, Miho Yoshizumi, Toshiya Murai Source Type: research

Can early dopamine transporter imaging serve as a predictor of Parkinson's disease progression and late motor complications?
This study investigated whether the degree of reduced striatal dopamine transporter binding at diagnosis of PD predicts later motor complications and time to disease progression. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 7, 2018 Category: Neurology Authors: Ruth Djaldetti, Amihai Rigbi, Lior Greenbaum, Johnathan Reiner, Mordechai Lorberboym Source Type: research

Non-right handed primary progressive apraxia of speech
This study evaluated the clinical and imaging findings in non-right handed compared to right handed participants in a prospective cohort diagnosed with primary progressive apraxia of speech. A total of 30 participants were included. Compared to the expected rate in the population, there was a higher prevalence of non-right handedness among those with primary progressive apraxia of speech (6/30, 20%). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 7, 2018 Category: Neurology Authors: Hugo Botha, Joseph R. Duffy, Jennifer L. Whitwell, Edythe A. Strand, Mary M. Machulda, Anthony Spychalla, Nirubol Tosakulwong, Matthew L. Senjem, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Val J. Lowe, Keith A. Josephs Source Type: research

Multimodal neuroimaging analysis in patients with SYNE1 Ataxia
The gene SYNE1 is highly expressed in the cerebellum and its dysfunction is related to an autosomal recessive ataxia (SYNE1-ataxia). The disease was firstly considered a pure cerebellar ataxia however, recent studies have described a broader clinical presentation, including motor neuron disease symptoms. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 4, 2018 Category: Neurology Authors: Maria T.D. Gama, Camila C. Piccinin, Thiago J.R. Rezende, Patrick A. Dion, Guy A. Rouleau, Marcondes C. Fran ça Junior, Orlando G. Barsottini, José Luiz Pedroso Source Type: research

Ticagrelor for stroke prevention in patients with vascular risk factors: A systematic review and meta-analysis
Even though ticagrelor was beneficial in prior cardiovascular trials, its efficacy in stroke prevention was inconclusive in recent randomized-controlled clinical trials (RCTs). We sought to consolidate the evidence for efficacy and safety of ticagrelor for stroke prevention. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 2, 2018 Category: Neurology Authors: Konark Malhotra, Nitin Goyal, Alissa S. Kasunich, Sunil A. Sheth, Aristeidis H. Katsanos, Andrei V. Alexandrov, Georgios Tsivgoulis Source Type: research

Paraneoplastic seesaw nystagmus and opsoclonus provides evidence for hyperexcitable reciprocally innervating mesencephalic network
Seesaw nystagmus is characterized by the rhythmic combination of vertical and torsional dysconjugate oscillations where one eye moves up and inward while the other moves down and outward. Common association of seesaw nystagmus with accessory optic track lesions lead to traditional hypothesis that it is due to the mismatch in the vision and vestibular systems. Here we propose a novel mechanism for seesaw nystagmus. We hypothesize that reverberations due to abnormal increases in the excitability of the reciprocally innervating circuit of excitatory burst neuron in the midbrain interstitial nucleus of Cajal causes the seesaw ...
Source: Journal of the Neurological Sciences - May 2, 2018 Category: Neurology Authors: Macym T. Rizvi, Lauren Cameron, Camilla Kilbane, Aasef G. Shaikh Source Type: research

Mutational analysis of TARDBP gene in patients affected by Parkinson's disease from Calabria
Neurodegenerative diseases are often characterized by the presence of intracellular or extracellular protein aggregates in the central nervous system. Mutations of TARDBP gene have been shown to cause Amyotrophic Lateral Sclerosis and have been reported to present with clinical heterogeneity including parkinsonism. TDP-43 pathology has been observed across a spectrum of neurodegenerative disorders, including Alzheimer's and Parkinson's disease. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 1, 2018 Category: Neurology Authors: Monica Gagliardi, Gennarina Arabia, Rita Nistic ò, Grazia Iannello, Radha Procopio, Lucia Manfredini, Grazia Annesi, Aldo Quattrone Tags: Clinical short communication Source Type: research

Migraine as possible red flag of PFO presence in suspected demyelinating disease
To investigate a possible association between isolated white matter lesions suggestive of demyelinating disease in magnetic resonance imaging (MRI) and patent foramen ovale (PFO) evidence in migraine patients, with or without aura. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 28, 2018 Category: Neurology Authors: E. Signoriello, M. Cirillo, G. Puoti, G. Signoriello, A. Negro, E. Koci, M.A.B. Melone, A. Rapacciuolo, G. Maresca, G. Lus Source Type: research

Neuropathy of peripheral nerves in Leber's hereditary optic neuropathy
With interest we read the article by Ciron et al. about a 63  yo male with Leber's hereditary optic neuropathy (LHON) due to the variant m.11778G>A in the ND4 gene in whom work-up for mild quadruparesis revealed symmetric, sensorimotor, axonal polyneuropathy with predominance of the upper limbs and demyelinating polyneuropathy in the lower limbs [1]. We have the following comments and concerns. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 26, 2018 Category: Neurology Authors: Josef Finsterer, Sinda Zarrouk-Mahjoub Tags: Letter to the Editor Source Type: research

Middle cerebral artery extension and the risk for aneurysmal disease
The intracranial artery aneurysm is an abnormal dilatation at the wall and the most serious complication is its rupture that is associated with high rates of neurological mortality and morbidity. Its most common location in arterial bifurcations suggests that the hemodynamic of blood flow plays a key role, but the effect of the length of the M1 segment of the middle cerebral artery is poorly explored. We analyzed biplanar brain angiograms to measure the extent of the M1 segment and its relationship to the presence of aneurysm at the bifurcation. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 25, 2018 Category: Neurology Authors: Carlos Eduardo Gouv êa da Cunha, Carolina da Cunha Correia Tags: Review Article Source Type: research

Clinical and radiological determinants of transient symptoms associated with infarction (TSI)
The definition of transient ischemic attack was traditionally based on clinical features only. The wide use of magnetic resonance imaging (MRI) led to the definition of a new entity - transient symptoms associated with infarction (TSI). It is unclear why patients with similar radiological infarctions may have different clinical manifestation – ranging from complete symptoms resolution to major neurological sequelae.We sought to determine which factors differentiate acute diffuse weighted imaging (DWI) lesion presentation - stroke versus TSI. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 23, 2018 Category: Neurology Authors: J. Molad, E. Ben-Assayag, A.D. Korczyn, E. Kliper, N.M. Bornstein, H. Hallevi, E. Auriel Source Type: research

Quantification of sweat gland innervation in patients with Fabry disease: A case-control study
Hypohidrosis and heat intolerance, frequently reported by men and women with Fabry disease (FD), is thought to be related not only to the deposition of globotriaosylceramide (Gb3) in eccrine sweat glands, but also to reduced sweat gland sympathetic innervation. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 21, 2018 Category: Neurology Authors: Panagiotis Kokotis, Nurcan Üçeyler, Christian Werner, Georgios Tsivgoulis, Nektaria Papanikola, Aristeidis H. Katsanos, Nikos Karandreas, Claudia Sommer Source Type: research

Cortical excitability variability: Insights into biological and behavioral characteristics of healthy individuals
Motor threshold (MT) measured by transcranial magnetic stimulation (TMS) has diagnostic utility in central nervous system disorders. Its diagnostic sensitivity may be enhanced by identification of non-pathological factors which may influence this measure. The aim of this study was to provide a description of MT variability across physiological and non-pathological behaviour characteristics in a large cohort, including hemispheric asymmetries. In a cross-sectional study, age, handedness, physical activity level, body mass index, gender/menstrual cycle phase, glycemic index and degree of stress were collected from 115 health...
Source: Journal of the Neurological Sciences - April 21, 2018 Category: Neurology Authors: A.P. Chagas, M. Monteiro, V. Mazer, A. Baltar, D. Marques, M. Carneiro, M.G. Rodrigues de Ara újo, D. Piscitelli, K.K. Monte-Silva Source Type: research

Genetic variants regulate NR1H3 expression and contribute to multiple sclerosis risk
A recent study analyzed 2053 multiple sclerosis (MS) cases and 799 healthy controls to investigate whether five genetic variants (rs11039149, rs12221497, rs2279238, rs7120118 and rs7114704) in NR1H3 are associated with MS risk. However this study reported negative results. It is very important that the appropriate samples and approach should be used in replication studies, which may provide the correct interpretation of the results. Here, we evaluated the above findings using large-scale MS genome-wide association studies with a total of 27,148 samples including 9772 MS cases and 17,376 controls, and multiple expression qu...
Source: Journal of the Neurological Sciences - April 21, 2018 Category: Neurology Authors: Yan Zhang, Longcai Wang, Haiyang Jia, Mingzhi Liao, Xiaoyun Chen, Jianyong Xu, Yunjuan Bao, Guiyou Liu Source Type: research

Quantification of sweat gland innervation in patients with Fabry disease: A case-control study
Hypohidrosis and heat intolerance, frequently reported by men and women with Fabry disease (FD), is thought to be related not only to the deposition of globotriaosylceramide (Gb3) in eccrine sweat glands, but also to reduced sweat gland sympathetic innervation. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 21, 2018 Category: Neurology Authors: Panagiotis Kokotis, Nurcan Üçeyler, Christian Werner, Georgios Tsivgoulis, Nektaria Papanikola, Aristeidis H. Katsanos, Nikos Karandreas, Claudia Sommer Source Type: research

Cortical excitability variability: Insights into biological and behavioral characteristics of healthy individuals
Motor threshold (MT) measured by transcranial magnetic stimulation (TMS) has diagnostic utility in central nervous system disorders. Its diagnostic sensitivity may be enhanced by identification of non-pathological factors which may influence this measure. The aim of this study was to provide a description of MT variability across physiological and non-pathological behaviour characteristics in a large cohort, including hemispheric asymmetries. In a cross-sectional study, age, handedness, physical activity level, body mass index, gender/menstrual cycle phase, glycemic index and degree of stress were collected from 115 health...
Source: Journal of the Neurological Sciences - April 21, 2018 Category: Neurology Authors: A.P. Chagas, M. Monteiro, V. Mazer, A. Baltar, D. Marques, M. Carneiro, M.G. Rodrigues de Ara újo, D. Piscitelli, K.K. Monte-Silva Source Type: research

Genetic variants regulate NR1H3 expression and contribute to multiple sclerosis risk
A recent study analyzed 2053 multiple sclerosis (MS) cases and 799 healthy controls to investigate whether five genetic variants (rs11039149, rs12221497, rs2279238, rs7120118 and rs7114704) in NR1H3 are associated with MS risk. However this study reported negative results. It is very important that the appropriate samples and approach should be used in replication studies, which may provide the correct interpretation of the results. Here, we evaluated the above findings using large-scale MS genome-wide association studies with a total of 27,148 samples including 9772 MS cases and 17,376 controls, and multiple expression qu...
Source: Journal of the Neurological Sciences - April 21, 2018 Category: Neurology Authors: Yan Zhang, Longcai Wang, Haiyang Jia, Mingzhi Liao, Xiaoyun Chen, Jianyong Xu, Yunjuan Bao, Guiyou Liu Source Type: research

Patent foramen ovale closure versus medical therapy for cryptogenic stroke: An updated meta-analysis
The efficacy of patent foramen ovale (PFO) closure for secondary stroke prevention in cryptogenic stroke (CS) patients with PFO is uncertain. This meta-analysis aims to assess whether PFO closure is superior to medical therapy. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: Hong-Bo Xu, Haigang Zhang, Yuju Qin, Fang Xue, Guilan Xiong, Liei Yang, Huanhuan Bai, Jinlan Wu Source Type: research

S100B, NSE and MMP-9 fail to predict neurologic outcome while elevated S100B associates with milder initial clinical presentation after aneurysmal subarachnoid hemorrhage
In this study, we evaluated the prognostic values of three promising biomarkers, i.e. S100B, NSE, and MMP-9 in aSAH. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: Heikki Kiiski, Jaakko L ångsjö, Jyrki Tenhunen, Marika Ala-Peijari, Heini Huhtala, Mari Hämäläinen, Eeva Moilanen, Jukka Peltola Source Type: research

Correlation between serum uric acid and diabetic peripheral neuropathy – association rather than causation
The correlation between uric acid levels and diabetic neuropathy as reported by Lin et al. is most likely an association with Metabolic Syndrome rather than cause [1]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: David S.H. Bell Tags: Letter to the Editor Source Type: research

A study of Huntington disease-like syndromes in black South African patients reveals a single SCA2 mutation and a unique distribution of normal alleles across five repeat loci
Huntington disease (HD) is a progressive neurodegenerative disease, characterised by a triad of movement disorder, emotional and behavioural disturbances and cognitive impairment. The underlying cause is an expanded CAG repeat in the huntingtin gene. For a small proportion of patients presenting with HD-like symptoms, the mutation in this gene is not identified and they are said to have a “HD phenocopy”.South Africa has the highest number of recorded cases of an African-specific phenocopy, Huntington disease-like 2 (HDL2), caused by a repeat expansion in the junctophilin-3 gene. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: Fiona K. Baine, Nabeelah Peerbhai, Amanda Krause Source Type: research

MRI venous architecture of insula
The purpose of this paper is to describe the venous anatomy of the insula using conventional MR brain imaging and confocal reconstructions in cases with glioma induced venous dilatation (venous gliography). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: Bhanu Gogia, Lakshmi S. Chavali, Fred Lang, L.A. Hayman, Prashant Rai, Sujit S. Prabhu, Donald F. Schomer, Vinodh A. Kumar Source Type: research

Orthostatic tachycardia with different onset time in patients with orthostatic intolerance
Abstract (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: Hyung Lee, Hyun Ah. Kim Source Type: research

Microbubble signal and trial of org in acute stroke treatment (TOAST) classification in ischemic stroke
Right-to-left shunt (RLS) through a patent foramen ovale (PFO) is likely associated with ischemic stroke. Many studies have attempted to demonstrate the association between RLS and ischemic stroke. However, information on the association between the degree of RLS and the subtypes of ischemic stroke categorized by the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification is lacking. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: Chan-Hyuk Lee, Hyun Goo Kang, Ji Sung Lee, Han Uk Ryu, Seul-Ki Jeong Source Type: research

Correlation between serum uric acid and diabetic peripheral neuropathy – association rather than causation
The correlation between uric acid levels and diabetic neuropathy as reported by Lin et al. is most likely an association with Metabolic Syndrome rather than cause [1]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: David S.H. Bell Tags: Letter to the Editor Source Type: research

Patent foramen ovale closure versus medical therapy for cryptogenic stroke: An updated meta-analysis
The efficacy of patent foramen ovale (PFO) closure for secondary stroke prevention in cryptogenic stroke (CS) patients with PFO is uncertain. This meta-analysis aims to assess whether PFO closure is superior to medical therapy. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: Hong-Bo Xu, Haigang Zhang, Yuju Qin, Fang Xue, Guilan Xiong, Liei Yang, Huanhuan Bai, Jinlan Wu Source Type: research

S100B, NSE and MMP-9 fail to predict neurologic outcome while elevated S100B associates with milder initial clinical presentation after aneurysmal subarachnoid hemorrhage
In this study, we evaluated the prognostic values of three promising biomarkers, i.e. S100B, NSE, and MMP-9 in aSAH. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: Heikki Kiiski, Jaakko L ångsjö, Jyrki Tenhunen, Marika Ala-Peijari, Heini Huhtala, Mari Hämäläinen, Eeva Moilanen, Jukka Peltola Source Type: research

A study of Huntington disease-like syndromes in black South African patients reveals a single SCA2 mutation and a unique distribution of normal alleles across five repeat loci
Huntington disease (HD) is a progressive neurodegenerative disease, characterised by a triad of movement disorder, emotional and behavioural disturbances and cognitive impairment. The underlying cause is an expanded CAG repeat in the huntingtin gene. For a small proportion of patients presenting with HD-like symptoms, the mutation in this gene is not identified and they are said to have a “HD phenocopy”.South Africa has the highest number of recorded cases of an African-specific phenocopy, Huntington disease-like 2 (HDL2), caused by a repeat expansion in the junctophilin-3 gene. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: Fiona K. Baine, Nabeelah Peerbhai, Amanda Krause Source Type: research

MRI venous architecture of insula
The purpose of this paper is to describe the venous anatomy of the insula using conventional MR brain imaging and confocal reconstructions in cases with glioma induced venous dilatation (venous gliography). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: Bhanu Gogia, Lakshmi S. Chavali, Fred Lang, L.A. Hayman, Prashant Rai, Sujit S. Prabhu, Donald F. Schomer, Vinodh A. Kumar Source Type: research

Orthostatic tachycardia with different onset time in patients with orthostatic intolerance
Abstract (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: Hyung Lee, Hyun Ah. Kim Source Type: research

Microbubble signal and trial of org in acute stroke treatment (TOAST) classification in ischemic stroke
Right-to-left shunt (RLS) through a patent foramen ovale (PFO) is likely associated with ischemic stroke. Many studies have attempted to demonstrate the association between RLS and ischemic stroke. However, information on the association between the degree of RLS and the subtypes of ischemic stroke categorized by the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification is lacking. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: Chan-Hyuk Lee, Hyun Goo Kang, Ji Sung Lee, Han Uk Ryu, Seul-Ki Jeong Source Type: research

Homozygote of spinocerebellar Ataxia type 3 correlating with severe phenotype based on analyses of clinical features
Spinocerebellar ataxia type 3 (SCA3) is the most common subtype of SCAs worldwide. SCA3 homozygote is defined as expanded CAG repeats in both alleles that might exhibit severe phenotype due to gene dosage effect. However, a study on the systematic comparison of clinical phenotypes between homozygotes and heterozygotes to indicate these verity of phenotypes of homozygotes is still lacking. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 18, 2018 Category: Neurology Authors: Xian-Jin Shang, Hao-Ling Xu, Jin-Shan Yang, Ping-Ping Chen, Min-Ting Lin, Mei-Zhen Qian, Hui-Xia Lin, Xiao-Ping Chen, Yu-Chao Chen, Bin Jiang, Yi-Jun Chen, Wan-Jin Chen, Ning Wang, Zhi-Ming Zhou, Shi-Rui Gan Source Type: research

Notch3 protein expression in skin fibroblasts from CADASIL patients
CADASIL is an inherited cerebrovascular disease caused by mutations in the NOTCH3 gene. Notch signaling is involved in a broad spectrum of function, from the cell proliferation to apoptosis. Thus far, because the molecular mechanism underlying the pathological alterations remains unclear and taking into account that fibroblasts contribute to the integrity of the vasculature, our aims was to establish whether fibroblasts, in subjects carrying different NOTCH3 mutations, show abnormalities in the protein expression. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 18, 2018 Category: Neurology Authors: Antonio Qualtieri, Carmine Ungaro, Angelo Bagal à, Silvia Bianchi, Leonardo Pantoni, Marcello Moccia, Rosalucia Mazzei Source Type: research