Adipose-derived stem cells promote survival, growth, and maturation of early-stage murine follicles
Premature ovarian insufficiency is a common complication of anticancer treatments in young women and girls. The ovary is a complex, highly regulated reproductive organ, whose proper function is contingent upon... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 21, 2019 Category: Stem Cells Authors: Lisa J. Green, Hong Zhou, Vasantha Padmanabhan and Ariella Shikanov Tags: Research Source Type: research

The effect of type 2 diabetes mellitus and obesity on muscle progenitor cell function
In addition to its primary function to provide movement and maintain posture, the skeletal muscle plays important roles in energy and glucose metabolism. In healthy humans, skeletal muscle is the major site fo... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 21, 2019 Category: Stem Cells Authors: Shuzhi Teng and Ping Huang Tags: Review Source Type: research

Exosomes derived from umbilical cord mesenchymal stem cells reduce microglia-mediated neuroinflammation in perinatal brain injury
Preterm newborns are at high risk of developing neurodevelopmental deficits caused by neuroinflammation leading to perinatal brain injury. Human Wharton ’s jelly mesenchymal stem cells (hWJ-MSC) derived from th... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 21, 2019 Category: Stem Cells Authors: Gierin Thomi, Daniel Surbek, Val érie Haesler, Marianne Joerger-Messerli and Andreina Schoeberlein Tags: Research Source Type: research

Exosomal miR-423-5p mediates the proangiogenic activity of human adipose-derived stem cells by targeting Sufu
Human adipose-derived stem cells (hADSCs) are an important source of cells for regenerative medicine. Evidence of extensive interactions with the surrounding microenvironment has led researchers to focus more ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 21, 2019 Category: Stem Cells Authors: Fen Xu, Qinqin Xiang, Jiuzuo Huang, Qianlong Chen, Nanze Yu, Xiao Long and Zhou Zhou Tags: Research Source Type: research

Transplantation of oral mucosal epithelial cells seeded on decellularized and lyophilized amniotic membrane for the regeneration of injured endometrium
Intrauterine adhesion (IUA) is characterized by progressive intrauterine fibrosis as a consequence of trauma to the basal layer of the endometrium. In an attempt to relieve IUA, many approaches have been appli... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 21, 2019 Category: Stem Cells Authors: Xing Chen, Jingtao Sun, Xiaoyu Li, Lele Mao, Lei Cui and Wenpei Bai Tags: Research Source Type: research

Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors
The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineer... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 19, 2019 Category: Stem Cells Authors: Elisabetta Manuela Foppiani, Olivia Candini, Ilenia Mastrolia, Alba Murgia, Giulia Grisendi, Anna Valeria Samarelli, Giulia Boscaini, Lucrezia Pacchioni, Massimo Pinelli, Giorgio De Santis, Edwin M. Horwitz, Elena Veronesi and Massimo Dominici Tags: Research Source Type: research

Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/ β-catenin pathway
Mesenchymal stem cells (MSCs) are increasingly being applied as a therapy for liver fibrosis. Exosomes possess similar functions to their parent cells; however, they are safe and effective cell-free reagents w... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 18, 2019 Category: Stem Cells Authors: Xiaoli Rong, Junzhi Liu, Xia Yao, Tiechao Jiang, Yimin Wang and Feng Xie Tags: Research Source Type: research

A comprehensive characterisation of large-scale expanded human bone marrow and umbilical cord mesenchymal stem cells
The manufacture of mesenchymal stem/stromal cells (MSCs) for clinical use needs to be cost effective, safe and scaled up. Current methods of expansion on tissue culture plastic are labour-intensive and involve... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 18, 2019 Category: Stem Cells Authors: Claire Mennan, John Garcia, Sally Roberts, Charlotte Hulme and Karina Wright Tags: Research Source Type: research

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature
Primary mesenchymal stem cells (MSCs) are fraught with aging-related shortfalls. Human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) have been shown to be a useful clinically relevant source of MSC... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 18, 2019 Category: Stem Cells Authors: Lucas-Sebastian Spitzhorn, Matthias Megges, Wasco Wruck, Md Shaifur Rahman, J örg Otte, Özer Degistirici, Roland Meisel, Rüdiger Volker Sorg, Richard O. C. Oreffo and James Adjaye Tags: Research Source Type: research

Skin tissue regeneration for burn injury
The skin is the largest organ of the body, which meets the environment most directly. Thus, the skin is vulnerable to various damages, particularly burn injury. Skin wound healing is a serious interaction betw... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 15, 2019 Category: Stem Cells Authors: Anastasia Shpichka, Denis Butnaru, Evgeny A. Bezrukov, Roman B. Sukhanov, Anthony Atala, Vitaliy Burdukovskii, Yuanyuan Zhang and Peter Timashev Tags: Review Source Type: research

Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte
It is confirmed that adipose-derived stem cells (ADSCs) transplantation effectively relieves kidney fibrosis and type 2 diabetes disease in mice. Currently, exosome from urine-derived stem cells (USCs) can pro... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 15, 2019 Category: Stem Cells Authors: Juan Jin, Yifen Shi, Jianguang Gong, Li Zhao, Yiwen Li, Qiang He and He Huang Tags: Research Source Type: research

Calpain inhibitor MDL28170 improves the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells following traumatic brain injury
Studies have shown that transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) protects against brain damage. However, the low survival number of transplanted BMSCs remains a pertinent challenge... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 15, 2019 Category: Stem Cells Authors: Jiangnan Hu, Lefu Chen, Xujun Huang, Ke Wu, Saidan Ding, Weikan Wang, Brian Wang, Charity Smith, Changhong Ren, Haoqi Ni, Qichuan ZhuGe and Jianjing Yang Tags: Research Source Type: research

Correction to: Modeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells
The original article [1] was submitted and published without co-author Hong Chen ’s permission. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 15, 2019 Category: Stem Cells Authors: Xuejiao Sun, Jianyuan Song, Hailong Huang, Hong Chen and Kun Qian Tags: Correction Source Type: research

Efficient generation of male germ-like cells derived during co-culturing of adipose-derived mesenchymal stem cells with Sertoli cells under retinoic acid and testosterone induction
Adipose-derived mesenchymal stem cells (ADMSCs) are considered an efficient and important candidate for male infertility treatment because they contain pluripotent stem cells, which can differentiate into all ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 13, 2019 Category: Stem Cells Authors: Yanxia Luo, Lili Xie, Ali Mohsin, Waqas Ahmed, Chenze Xu, Yan Peng, Haifeng Hang, Yingping Zhuang, Ju Chu and Meijin Guo Tags: Research Source Type: research

HMGB1-modified mesenchymal stem cells attenuate radiation-induced vascular injury possibly via their high motility and facilitation of endothelial differentiation
Vascular injury is one of the most common detrimental effects of cancer radiotherapy on healthy tissues. Since the efficacy of current preventive and therapeutic strategies remains limited, the exploration of ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 13, 2019 Category: Stem Cells Authors: Xuan Tao, Mingyang Sun, Min Chen, Rongchao Ying, Wenjie Su, Jian Zhang, Xiaodong Xie, Wei Wei and Xiaohu Meng Tags: Research Source Type: research

Human ADSC xenograft through IL-6 secretion activates M2 macrophages responsible for the repair of damaged muscle tissue
Adipose-derived mesenchymal stromal cells (ADSCs) are multipotent stromal cells. The cells secrete a number of cytokines and growth factors and show immunoregulatory and proangiogenic properties. Their propert... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 13, 2019 Category: Stem Cells Authors: Ewelina Pilny, Ryszard Smolarczyk, Magdalena Jarosz-Biej, Alina Hadyk, Agnieszka Skorupa, Mateusz Ciszek, Łukasz Krakowczyk, Natalia Kułach, Danuta Gillner, Maria Sokół, Stanisław Szala and Tomasz Cichoń Tags: Research Source Type: research

Exploiting tumor-intrinsic signals to induce mesenchymal stem cell-mediated suicide gene therapy to fight malignant glioma
Human mesenchymal stem cell (MSC)-based tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene delivery is regarded as an effective treatment for glioblastoma (GBM). However, adverse-free target ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 12, 2019 Category: Stem Cells Authors: Man Li, Shoujia Sun, Sean Dangelmajer, Quan Zhang, Junwen Wang, Feng Hu, Fangyong Dong, Ulf D. Kahlert, Mingxin Zhu and Ting Lei Tags: Research Source Type: research

The therapeutic effects of bone marrow-derived mesenchymal stromal cells in the acute lung injury induced by sulfur mustard
Sulfur mustard (SM) is a notorious chemical warfare agent that can cause severe acute lung injury (ALI), in addition to other lesions. Currently, effective medical countermeasures for SM are lacking. Bone marr... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 12, 2019 Category: Stem Cells Authors: Yongwei Feng, Qingqiang Xu, Yuyan Yang, Wenwen Shi, Wenqi Meng, Hao Zhang, Xiaowen He, Mingxue Sun, Yongchun Chen, Jie Zhao, Zhenhong Guo and Kai Xiao Tags: Research Source Type: research

The potential and limitations of induced pluripotent stem cells to achieve wound healing
Wound healing is the physiologic response to a disruption in normal skin architecture and requires both spatial and temporal coordination of multiple cell types and cytokines. This complex process is prone to ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 12, 2019 Category: Stem Cells Authors: Jolanta Gorecka, Valentyna Kostiuk, Arash Fereydooni, Luis Gonzalez, Jiesi Luo, Biraja Dash, Toshihiko Isaji, Shun Ono, Shirley Liu, Shin Rong Lee, Jianbiao Xu, Jia Liu, Ryosuke Taniguchi, Bogdan Yastula, Henry C. Hsia, Yibing Qyang & hellip; Tags: Review Source Type: research

Analysis of the characteristics and expression profiles of coding and noncoding RNAs of human dental pulp stem cells in hypoxic conditions
In this study, we ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 12, 2019 Category: Stem Cells Authors: Ruitang Shi, Haoqing Yang, Xiao Lin, Yangyang Cao, Chen Zhang, Zhipeng Fan and Benxiang Hou Tags: Research Source Type: research

Exosomes secreted by urine-derived stem cells improve stress urinary incontinence by promoting repair of pubococcygeus muscle injury in rats
Previous studies revealed that urine-derived stem cells (USCs) could promote myogenesis after the impairment of the sphincter muscles. However, the effects of exosomes secreted by USCs (USCs-Exo) were not eluc... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 8, 2019 Category: Stem Cells Authors: Ruoyu Wu, Chengsheng Huang, Qingkai Wu, Xiang Jia, Mengyu Liu, Zhuowei Xue, Yu Qiu, Xin Niu and Yang Wang Tags: Research Source Type: research

Differentiation roadmap of embryonic Sertoli cells derived from mouse embryonic stem cells
Embryonic Sertoli cells (eSCs) play an important role in sex determination and in male gonad development which makes them a very useful cell type for therapeutic applications. However, the deriving mechanism o... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 8, 2019 Category: Stem Cells Authors: Chenze Xu, Ali Mohsin, Yanxia Luo, Lili Xie, Yan Peng, Qizheng Wang, Haifeng Hang, Yingping Zhuang and Meijin Guo Tags: Research Source Type: research

In vitro expansion affects the response of human bone marrow stromal cells to irradiation
Bone marrow stromal cells (BMSCs) are extensively used in regeneration therapy and cytology experiments simulate how BMSCs respond to radiation. Due to the small number and the heterogeneity of primary isolate... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 8, 2019 Category: Stem Cells Authors: Yang Xiang, Chun Wu, Jiang Wu, Weili Quan, Chao Cheng, Jian Zhou, Li Chen, Lixin Xiang, Fengjie Li, Kebin Zhang, Qian Ran, Yi Zhang and Zhongjun Li Tags: Research Source Type: research

Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure
Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived car... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 7, 2019 Category: Stem Cells Authors: Songyan Liao, Yuelin Zhang, Sherwin Ting, Zhe Zhen, Fan Luo, Ziyi Zhu, Yu Jiang, Sijia Sun, Wing-Hon Lai, Qizhou Lian and Hung-Fat Tse Tags: Research Source Type: research

Human serum enhances the proliferative capacity and immunomodulatory property of MSCs derived from human placenta and umbilical cord
Mesenchymal stromal cells (MSCs) are considered potential candidates that hold great promise in the treatment of immune-related diseases. For therapeutic applications, it is necessary to isolate and expand MSC... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 7, 2019 Category: Stem Cells Authors: Sermporn Thaweesapphithak, Chairat Tantrawatpan, Pakpoom Kheolamai, Duangrat Tantikanlayaporn, Sittiruk Roytrakul and Sirikul Manochantr Tags: Research Source Type: research

Overexpressing p130/E2F4 in mesenchymal stem cells facilitates the repair of injured alveolar epithelial cells in LPS-induced ARDS mice
Low differentiation rates of mesenchymal stem cells (MSCs) limit their therapeutic effects on patients in clinical studies. Our previous study demonstrated that overexpressing p130 or E2F4 affected the multipo... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 6, 2019 Category: Stem Cells Authors: Xiwen Zhang, Jianxiao Chen, Ming Xue, Yuying Tang, Jingyuan Xu, Ling Liu, Yingzi Huang, Yi Yang, Haibo Qiu and Fengmei Guo Tags: Research Source Type: research

Regenerative cell therapy for pulmonary arterial hypertension in animal models: a systematic review
Pulmonary arterial hypertension (PAH) is a rare disease characterized by widespread loss of the pulmonary microcirculation and elevated pulmonary arterial pressures leading to pathological right ventricular re... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 6, 2019 Category: Stem Cells Authors: Colin M. Suen, Duncan J. Stewart, Joshua Montroy, Christopher Welsh, Brendan Levac, Neil Wesch, Alexander Zhai, Dean Fergusson, Lauralyn McIntyre and Manoj M. Lalu Tags: Research Source Type: research

Mesenchymal stem cell-loaded porous tantalum integrated with biomimetic 3D collagen-based scaffold to repair large osteochondral defects in goats
The body is unable to repair and regenerate large area bone defects. Moreover, the repair capacity of articular cartilage is very limited. There has long been a lack of effective treatments for osteochondral l... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 5, 2019 Category: Stem Cells Authors: Xiaowei Wei, Baoyi Liu, Ge Liu, Fan Yang, Fang Cao, Xiaojie Dou, Weiting Yu, Benjie Wang, Guoshuang Zheng, Liangliang Cheng, Zhijie Ma, Yu Zhang, Jiahui Yang, Zihua Wang, Junlei Li, Daping Cui & hellip; Tags: Research Source Type: research

Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells
Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough research is required into their clinical application sa... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 5, 2019 Category: Stem Cells Authors: Svitlana Melnik, Nadine Werth, Stephane Boeuf, Eva-Maria Hahn, Tobias Gotterbarm, Martina Anton and Wiltrud Richter Tags: Research Source Type: research

Continuous exposure of isoprenaline inhibits myoblast differentiation and fusion through PKA/ERK1/2-FOXO1 signaling pathway
The objective of this study is to determine if exuberant sympathetic nerve activity is involved in muscle satellite cell differentiation and myoblast fusion. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 28, 2019 Category: Stem Cells Authors: Shao-juan Chen, Jing Yue, Jing-Xuan Zhang, Miao Jiang, Tu-qiang Hu, Wei-dong Leng, Li Xiang, Xin-yuan Li, Lei Zhang, Fei Zheng, Ye Yuan, Lin-yun Guo, Ya-mu Pan, Yu-wen Yan, Jia-ning Wang, Shi-You Chen & hellip; Tags: Research Source Type: research

A novel approach to label bone marrow-derived mesenchymal stem cells with mixed-surface PAMAM dendrimers
Transplantation of mesenchymal stem cells has created enormous opportunities as a potential treatment for various diseases including neurodegenerative diseases. Given current techniques, such as Hoechst labeli... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 28, 2019 Category: Stem Cells Authors: Nikolas Munro, Bhairavi Srinageshwar, Firas Shalabi, Maria Florendo, Paulina Otero, Cassandra Thompson, Jordyn Kippe, Clayton Malkowski, Sydney Climie, Andrew N. Stewart, Rachel Kim, Joseph Zhou, Douglas Swanson, Gary L. Dunbar, Ajit Sharma and Julien Ros Tags: Research Source Type: research

Stem cells: past, present, and future
In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations. This paper is a review focused on the ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 26, 2019 Category: Stem Cells Authors: Wojciech Zakrzewski, Maciej Dobrzy ński, Maria Szymonowicz and Zbigniew Rybak Tags: Review Source Type: research

Automated digital image quantification of histological staining for the analysis of the trilineage differentiation potential of mesenchymal stem cells
Multipotent mesenchymal stem cells (MSCs) have the potential to repair and regenerate damaged tissues and are considered as attractive candidates for the development of cell-based regenerative therapies. Curre... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 26, 2019 Category: Stem Cells Authors: Benjamin Eggerschwiler, Daisy D. Canepa, Hans-Christoph Pape, Elisa A. Casanova and Paolo Cinelli Tags: Method Source Type: research

Autologous mesenchymal stromal cells embedded in tricalcium phosphate for posterolateral spinal fusion: results of a prospective phase I/II clinical trial with long-term follow-up
Posterolateral spinal fusion with autologous bone graft is considered the “gold standard” for lumbar degenerative disc disease (DDD) when surgical treatment is indicated. The potential role of mesenchymal stro... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 22, 2019 Category: Stem Cells Authors: Juan F. Blanco, Eva M. Villar ón, David Pescador, Carmen da Casa, Victoria Gómez, Alba M. Redondo, Olga López-Villar, Miriam López-Parra, Sandra Muntión and Fermín Sánchez-Guijo Tags: Research Source Type: research

BAM15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue
BAM15 is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage. The purpose of our study was to investigate... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 22, 2019 Category: Stem Cells Authors: Mingjun Tang, Ziming Luo, Yihui Wu, Jing Zhuang, Kaijing Li, Dongpeng Hu, Huifeng Rong, Bikun Xian and Jian Ge Tags: Research Source Type: research

miRNA-21 promotes osteogenesis via the PTEN/PI3K/Akt/HIF-1 α pathway and enhances bone regeneration in critical size defects
Functional reconstruction of maxillofacial bone defects is a considerable clinical challenge. Many studies have emphasized the osteogenic and angiopoietic abilities of stem cells for tissue regeneration. We pr... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 22, 2019 Category: Stem Cells Authors: Chi Yang, Xiaohan Liu, Kai Zhao, Youming Zhu, Bin Hu, Yong Zhou, Mohan Wang, Yiqun Wu, Chengfei Zhang, Jianguang Xu, Yujie Ning and Duohong Zou Tags: Research Source Type: research

Priming with Toll-like receptor 3 agonist or interferon-gamma enhances the therapeutic effects of human mesenchymal stem cells in a murine model of atopic dermatitis
Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease. Great efforts have been recently made to treat AD using mesenchymal stem cells (MSCs), which have immunomodulatory functions. Howeve... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 22, 2019 Category: Stem Cells Authors: Arum Park, Hyojung Park, Jisun Yoon, Dayeon Kang, Myoung-Hee Kang, Y-Y Park, Nayoung Suh and Jinho Yu Tags: Research Source Type: research

Long noncoding RNA LINC00707 sponges miR-370-3p to promote osteogenesis of human bone marrow-derived mesenchymal stem cells through upregulating WNT2B
Human bone marrow-derived mesenchymal stem cells (HBMSCs) are characterized by multiple differentiation potential and potent self-renewal ability, yet much remains to be elucidated on what determines these pro... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 22, 2019 Category: Stem Cells Authors: Bo Jia, Zhiping Wang, Xiang Sun, Jun Chen, Jianjiang Zhao and Xiaoling Qiu Tags: Research Source Type: research

Platelet-rich plasma improves therapeutic effects of menstrual blood-derived stromal cells in rat model of intrauterine adhesion
Intrauterine adhesion (IUA) is a major cause of female secondary infertility. We previously demonstrated that menstrual blood-derived stromal cell (MenSC) transplantation helped severe IUA patients have pregna... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 15, 2019 Category: Stem Cells Authors: Siwen Zhang, Pingping Li, Zhengwei Yuan and Jichun Tan Tags: Research Source Type: research

Exosomes from glioma cells induce a tumor-like phenotype in mesenchymal stem cells by activating glycolysis
Exosomes are nanoscale membrane vesicles secreted by both normal and cancer cells, and cancer cell-derived exosomes play an important role in the cross-talk between cancer cells and other cellular components i... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 15, 2019 Category: Stem Cells Authors: Zhanjun Ma, Xue Cui, Li Lu, Guohu Chen, Yang Yang, Yan Hu, Yubao Lu, Zhangqi Cao, Yan Wang and Xuexi Wang Tags: Research Source Type: research

microRNA-690 regulates induced pluripotent stem cells (iPSCs) differentiation into insulin-producing cells by targeting Sox9
The regulatory mechanism of insulin-producing cells (IPCs) differentiation from induced pluripotent stem cells (iPSCs) in vitro is very important in the phylogenetics of pancreatic islets, the molecular pathog... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 15, 2019 Category: Stem Cells Authors: Yang Xu, Yan Huang, Yibing Guo, Yicheng Xiong, Shajun Zhu, Liancheng Xu, Jingjing Lu, Xiaohong Li, Jian Wan, Yuhua Lu and Zhiwei Wang Tags: Research Source Type: research

Immunoregulatory potential of mesenchymal stem cells following activation by macrophage-derived soluble factors
Immunoregulatory capacity of mesenchymal stem cells (MSC) is triggered by the inflammatory environment, which changes during tissue repair. Macrophages are essential in mediating the inflammatory response afte... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 13, 2019 Category: Stem Cells Authors: Laura Salda ña, Fátima Bensiamar, Gema Vallés, Francisco J. Mancebo, Eduardo García-Rey and Nuria Vilaboa Tags: Research Source Type: research

Dermal mesenchymal stem cells: a resource of migration-associated function in psoriasis?
Psoriasis is a chronic and systemic, immune-mediated, inflammatory disease. Mesenchymal stem cells have effects on the inflammatory microenvironment, including regulating the proliferation, differentiation, re... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 13, 2019 Category: Stem Cells Authors: Xuping Niu, Junqing Li, Xincheng Zhao, Qiang Wang, Gang Wang, Ruixia Hou, Xinhua Li, Peng An, Guohua Yin and Kaiming Zhang Tags: Research Source Type: research

Inhibition of PTGS1 promotes osteogenic differentiation of adipose-derived stem cells by suppressing NF-kB signaling
Tissue inflammation is an important problem in the field of human adipose-derived stem cell (ASC)-based therapeutic bone regeneration. Many studies indicate that inflammatory cytokines are disadvantageous for ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 13, 2019 Category: Stem Cells Authors: Yuejun Wang, Yunsong Liu, Min Zhang, Longwei Lv, Xiao Zhang, Ping Zhang and Yongsheng Zhou Tags: Research Source Type: research

The role of the vasculature niche on insulin-producing cells generated by transdifferentiation of adult human liver cells
Insulin-dependent diabetes is a multifactorial disorder that could be theoretically cured by functional pancreatic islets and insulin-producing cell (IPC) implantation. Regenerative medicine approaches include... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 13, 2019 Category: Stem Cells Authors: Irit Meivar-Levy, Fatima Zoabi, Gil Nardini, Eugenia Manevitz-Mendelson, Gil S. Leichner, Oranit Zadok, Michael Gurevich, Eytan Mor, Simona Dima, Irinel Popescu, Aviv Barzilai, Sarah Ferber and Shoshana Greenberger Tags: Research Source Type: research

Efficacy of stem cell therapy for pulmonary arterial hypertension: a systematic review and meta-analysis of preclinical studies
Despite significant progress in drug treatment, the prognosis of patients with advanced pulmonary arterial hypertension (PAH) remains extremely poor. Many preclinical studies have reported the efficacy of stem... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 13, 2019 Category: Stem Cells Authors: Xian-Fei Ding, Huo-Yan Liang, Bo Yuan, Li-Feng Li, Tian Wang, Quan-Cheng Kan, Le-Xin Wang and Tong-Wen Sun Tags: Research Source Type: research

Mesenchymal stem/stromal cell function in modulating cell death
Mesenchymal stem/stromal cells (MSCs) delivered as cell therapy to individuals with degenerative and/or inflammatory disorders can help improve organ features and resolve inflammation, as demonstrated in precl... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 13, 2019 Category: Stem Cells Authors: Abderrahim Naji, Benoit Favier, Fr édéric Deschaseaux, Nathalie Rouas-Freiss, Masamitsu Eitoku and Narufumi Suganuma Tags: Review Source Type: research

Mesenchymal stem cell 3D encapsulation technologies for biomimetic microenvironment in tissue regeneration
Mesenchymal stem cell (MSC) encapsulation technique has long been emerged in tissue engineering as it plays an important role in implantation of stem cells to regenerate a damaged tissue. MSC encapsulation pro... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 7, 2019 Category: Stem Cells Authors: Hyerim Kim, Chaewon Bae, Yun-Min Kook, Won-Gun Koh, Kangwon Lee and Min Hee Park Tags: Review Source Type: research

Preconditioning human natural killer cells with chorionic villous mesenchymal stem cells stimulates their expression of inflammatory and anti-tumor molecules
Mesenchymal stem cells derived from the chorionic villi of human placentae (pMSCs) produce a unique array of mediators that regulate the essential cellular functions of their target cells. These properties mak... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 6, 2019 Category: Stem Cells Authors: M. H. Abumaree, N. A. Alshehri, A. Almotery, A. M. Al Subayyil, E. Bahattab, F. M. Abomaray, T. Khatlani, B. Kalionis, D. Jawdat, M. F. El-Muzaini, M. A. Al Jumah and A. S. AlAskar Tags: Research Source Type: research

Correction to: Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells
Following publication of the original article in Stem Cell Research& Therapy [1], we would like to alert the reader that the immune-histological sections shown in Figure 2 bottom line are mistakenly the image... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 31, 2019 Category: Stem Cells Authors: Adel Tekari, Samantha C. W. Chan, Daisuke Sakai, Sibylle Grad and Benjamin Gantenbein Tags: Correction Source Type: research