NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation
Understanding the biology underlying the mechanisms and pathways regulating pancreatic β cell development is necessary to understand the pathology of diabetes mellitus (DM), which is characterized by the progr... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 29, 2020 Category: Stem Cells Authors: Idil I. Aigha and Essam M. Abdelalim Tags: Review Source Type: research

Epidrugs: novel epigenetic regulators that open a new window for targeting osteoblast differentiation
Efficient osteogenic differentiation of mesenchymal stem cells (MSCs) is a critical step in the treatment of bone defects and skeletal disorders, which present challenges for cell-based therapy and regenerativ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 28, 2020 Category: Stem Cells Authors: Mahsa Ghorbaninejad, Maliheh Khademi-Shirvan, Samaneh Hosseini and Mohamadreza Baghaban Eslaminejad Tags: Review Source Type: research

Development and validation of a novel stem cell subtype for bladder cancer based on stem genomic profiling
Bladder cancer (BLCA) is the fifth most common type of cancer worldwide, with high recurrence and progression rates. Although considerable progress has been made in the treatment of BLCA through accurate typin... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 28, 2020 Category: Stem Cells Authors: Chaozhi Tang, Jiakang Ma, Xiuli Liu and Zhengchun Liu Tags: Research Source Type: research

Autologous peripheral blood-derived stem cells transplantation for treatment of no-option angiitis-induced critical limb ischemia: 10-year management experience
Previous studies have demonstrated that no-option angiitis-induced critical limb ischemia (NO-AICLI) could be significantly improved by transplantation of peripheral blood-derived stem cells (PBDSCs). Addition... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 28, 2020 Category: Stem Cells Authors: Gang Fang, Xiaolang Jiang, Yuan Fang, Tianyue Pan, Hao Liu, Bichen Ren, Zheng Wei, Shiyang Gu, Bin Chen, Junhao Jiang, Yun Shi, Daqiao Guo, Peng Liu, Weiguo Fu and Zhihui Dong Tags: Research Source Type: research

Treating primary immunodeficiencies with defects in NK cells: from stem cell therapy to gene editing
Primary immunodeficiency diseases (PIDs) are rare diseases that are characterized by genetic mutations that damage immunological function, defense, or both. Some of these rare diseases are caused by aberration... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 27, 2020 Category: Stem Cells Authors: C. Eguizabal, L. Herrera, M. Ingl és-Ferrándiz and J. C. Izpisua Belmonte Tags: Review Source Type: research

RNA-seq reveals tight junction-relevant erythropoietic fate induced by OCT4 in human hair follicle mesenchymal stem cells
Human hair follicle mesenchymal stem cells (hHFMSCs) isolated from hair follicles possess multilineage differentiation potential. OCT4 is a gene critically associated with pluripotency properties. The cell mor... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 27, 2020 Category: Stem Cells Authors: Xiaozhen Yu, Pengpeng Sun, Xingang Huang, Hua Chen, Weiqing Huang, Yingchun Ruan, Weina Jiang, Xiaohua Tan and Zhijing Liu Tags: Research Source Type: research

microRNA-375 released from extracellular vesicles of bone marrow mesenchymal stem cells exerts anti-oncogenic effects against cervical cancer
Cervical cancer is the most prevalent gynecological malignancies accompanied by high mortality, where finding a more effective therapeutic option for cervical cancer is necessary. The inhibitory role of microR... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 27, 2020 Category: Stem Cells Authors: Feng Ding, Jinhua Liu and Xiaofei Zhang Tags: Research Source Type: research

miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway
We have previously verified the beneficial effects of exosomes from endothelial progenitor cells (EPC-EXs) in ischemic stroke. However, the effects of EPC-EXs in hemorrhagic stroke have not been investigated. ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 26, 2020 Category: Stem Cells Authors: Yuchen Li, Jinju Wang, Shuzhen Chen, Pei Wu, Shancai Xu, Chunlei Wang, Huaizhang Shi and Ji Bihl Tags: Research Source Type: research

Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids
Gene therapy is being investigated for a range of serious lung diseases, such as cystic fibrosis and emphysema. Recombinant adeno-associated virus (rAAV) is a well-established, safe, viral vector for gene deli... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 23, 2020 Category: Stem Cells Authors: Helena Meyer-Berg, Lucia Zhou Yang, Mar ía Pilar de Lucas, Alberto Zambrano, Stephen C. Hyde and Deborah R. Gill Tags: Short report Source Type: research

Co-encapsulation of HNF4 α overexpressing UMSCs and human primary hepatocytes ameliorates mouse acute liver failure
Acute liver failure (ALF) is a complicated condition that is characterized by global hepatocyte death and often requires immediate liver transplantation. However, this therapy is limited by shortage of donor o... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 23, 2020 Category: Stem Cells Authors: Defu Kong, Huiming Xu, Mo Chen, Yeping Yu, Yongbing Qian, Tian Qin, Ying Tong, Qiang Xia and Hualian Hang Tags: Research Source Type: research

HSPB7 regulates osteogenic differentiation of human adipose derived stem cells via ERK signaling pathway
Heat shock protein B7 (HSPB7), which belongs to small heat shock protein family, has been reported to be involved in diverse biological processes and diseases. However, whether HSPB7 regulates osteogenic differen... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 23, 2020 Category: Stem Cells Authors: Chanyuan Jin, Ting Shuai and Zhihui Tang Tags: Research Source Type: research

Regenerative medicine approaches for the management of respiratory tract fistulas
Respiratory tract fistulas (or fistulae) are abnormal communications between the respiratory system and the digestive tract or the adjacent organs. The origin can be congenital or, more frequently, iatrogenic ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 23, 2020 Category: Stem Cells Authors: Angelo Trivisonno, Dania Nachira, Ivo Bo škoski, Venanzio Porziella, Giuliana Di Rocco, Silvia Baldari and Gabriele Toietta Tags: Review Source Type: research

Epidermal stem cell-derived exosomes promote skin regeneration by downregulating transforming growth factor- β1 in wound healing
Scar formation, which may be caused by myofibroblast aggregations, is the greatest challenge during skin wound healing in the clinical setting. Studies have indicated that epidermal stem cells (EPSC) improve w... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 23, 2020 Category: Stem Cells Authors: Mengna Duan, Yan Zhang, Haiyang Zhang, Yupeng Meng, Ming Qian and Guokun Zhang Tags: Research Source Type: research

Correction to: Epidermal stem cells in wound healing and their clinical applications
An amendment to this paper has been published and can be accessed via the original article. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 22, 2020 Category: Stem Cells Authors: Ronghua Yang, Fengxia Liu, Jingru Wang, Xiaodong Chen, Julin Xie and Kun Xiong Tags: Correction Source Type: research

DNMT1-mediated methylation inhibits microRNA-214-3p and promotes hair follicle stem cell differentiate into adipogenic lineages
Dysfunction of the DNA methylation was associated with stem cell reprogramming. Moreover, DNA methyltransferase 1 (DNMT1) deficiency was involved in the differentiation of hair follicle stem cell (HFSc), but t... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 19, 2020 Category: Stem Cells Authors: Fangcao Jin, Min Li, Xuyang Li, Yunpeng Zheng, Kun Zhang, Xiaojun Liu, Bingjie Cai and Guangwen Yin Tags: Research Source Type: research

Efficacy and safety of stem cell therapy for the early-stage osteonecrosis of femoral head: a systematic review and meta-analysis of randomized controlled trials
Osteonecrosis of femoral head (ONFH) is a seriously degenerative disease with no effective therapies to slow its progression. Several studies have reported short-term efficacy of stem cells on early-stage ONFH... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 19, 2020 Category: Stem Cells Authors: Lianghao Mao, Pan Jiang, Xuan Lei, Chenlie Ni, Yiming Zhang, Bing Zhang, Qiping Zheng and Dapeng Li Tags: Review Source Type: research

Correction to: MEIS2 regulates endothelial to hematopoietic transition of human embryonic stem cells by targeting TAL1
An amendment to this paper has been published and can be accessed via the original article. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 19, 2020 Category: Stem Cells Authors: Mengge Wang, Hongtao Wang, Yuqi Wen, Xiaoyuan Chen, Xin Liu, Jie Gao, Pei Su, Yuanfu Xu, Wen Zhou, Lihong Shi and Jiaxi Zhou Tags: Correction Source Type: research

Correction to: Extracellular vesicles from human mesenchymal stem cells expedite chondrogenesis in 3D human degenerative disc cell cultures
An amendment to this paper has been published and can be accessed via the original article. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 16, 2020 Category: Stem Cells Authors: Daphne Hingert, Karin Ekstr öm, Jonathan Aldridge, Rossella Crescitelli and Helena Brisby Tags: Correction Source Type: research

Lineage tracing: technology tool for exploring the development, regeneration, and disease of the digestive system
Lineage tracing is the most widely used technique to track the migration, proliferation, and differentiation of specific cells in vivo. The currently available gene-targeting technologies have been developing ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 15, 2020 Category: Stem Cells Authors: Yue Zhang, Fanhong Zeng, Xu Han, Jun Weng and Yi Gao Tags: Review Source Type: research

Application of human amniotic epithelial cells in regenerative medicine: a systematic review
Human amniotic epithelial cells (hAECs) derived from placental tissues have gained considerable attention in the field of regenerative medicine. hAECs possess embryonic stem cell-like proliferation and differe... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 15, 2020 Category: Stem Cells Authors: Qiuwan Zhang and Dongmei Lai Tags: Review Source Type: research

BKCa channels regulate the immunomodulatory properties of WJ-MSCs by affecting the exosome protein profiles during the inflammatory response
Wharton ’s jelly-derived mesenchymal stem cells (WJ-MSCs) from the human umbilical cord have been studied extensively due to their immunomodulatory functions. Large-conductance Ca2+-activated K+ (BKCa channels) ch... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 15, 2020 Category: Stem Cells Authors: Ahui Song, Jingjing Wang, Yan Tong, Junyan Fang, Yi Zhang, Huiping Zhang, Hongqiang Ruan, Kai Wang and Yingli Liu Tags: Research Source Type: research

TUG1 enhances high glucose-impaired endothelial progenitor cell function via miR-29c-3p/PDGF-BB/Wnt signaling
Diabetes is associated with the dysfunction of endothelial progenitor cells (EPCs), characterized as impaired angiogenesis, a phenomenon thought to be involved in the development of diabetic foot. lncRNA plays... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 15, 2020 Category: Stem Cells Authors: Yang Li, Kangkang Zhi, Shilong Han, Xue Li, Maoquan Li, Weishuai Lian, Haijun Zhang and Xiaoping Zhang Tags: Research Source Type: research

Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage
Bone marrow mesenchymal stem cells (BMSCs) have been used as important cell-based tools for clinical applications. Oxidative stress-induced apoptosis causes a low survival rate after transplantation, and the u... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 15, 2020 Category: Stem Cells Authors: Chongxi Fan, Jianyu Feng, Chi Tang, Zhengbin Zhang, Yingtong Feng, Weixun Duan, Mingming Zhai, Zedong Yan, Liwen Zhu, Lele Feng, Hanzhao Zhu and Erping Luo Tags: Research Source Type: research

Inhibition of hypertrophy and improving chondrocyte differentiation by MMP-13 inhibitor small molecule encapsulated in alginate-chondroitin sulfate-platelet lysate hydrogel
Mesenchymal stem cells are a promising cell source for chondrogenic differentiation and have been widely used in several preclinical and clinical studies. However, they are prone to an unwanted differentiation... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 9, 2020 Category: Stem Cells Authors: Shahrbanoo Jahangir, David Eglin, Naomi P ötter, Mojtaba Khozaei Ravari, Martin J. Stoddart, Ali Samadikuchaksaraei, Mauro Alini, Mohammadreza Baghaban Eslaminejad and Majid Safa Tags: Research Source Type: research

Optimal H2O2 preconditioning to improve bone marrow mesenchymal stem cells ’ engraftment in wound healing
The transplantation of bone marrow mesenchymal stem cells (BMSCs) is a promising therapeutic strategy for wound healing. However, the poor migration capacity and low survival rate of transplanted BMSCs in woun... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 8, 2020 Category: Stem Cells Authors: Ling Guo, Juan Du, Dan-feng Yuan, Ya Zhang, Shu Zhang, Hua-cai Zhang, Jun-wei Mi, Ya-lei Ning, Min-jia Chen, Da-lin Wen, Jian-hui Sun, Di Liu, Ling Zeng, Anqiang Zhang, Jianxin Jiang and Hong Huang Tags: Research Source Type: research

Epigenetic silencing of KLF2 by long non-coding RNA SNHG1 inhibits periodontal ligament stem cell osteogenesis differentiation
Exploring the effects of lncRNA SNHG1 in the process of osteogenic differentiation of periodontal ligament stem cells (PDLSCs) would provide novel therapeutic strategies for tissue regeneration. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 7, 2020 Category: Stem Cells Authors: Zhaobao Li, Xiangjun Guo and Shuainan Wu Tags: Research Source Type: research

Human platelet lysate as a potential clinical-translatable supplement to support the neurotrophic properties of human adipose-derived stem cells
The autologous nerve graft, despite its donor site morbidity and unpredictable functional recovery, continues to be the gold standard in peripheral nerve repair. Rodent research studies have shown promising re... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 6, 2020 Category: Stem Cells Authors: Silvia Palombella, Martino Guiotto, Gillian C. Higgins, Laurent L. Applegate, Wassim Raffoul, Mario Cherubino, Andrew Hart, Mathis O. Riehle and Pietro G. di Summa Tags: Research Source Type: research

Effects of electromagnetic fields treatment on rat critical-sized calvarial defects with a 3D-printed composite scaffold
Current strategies for craniofacial defect are faced with unmet outcome. Combining 3D-printing with safe, noninvasive magnetic therapy could be a promising breakthrough. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 6, 2020 Category: Stem Cells Authors: Chang Tu, Jingyuan Chen, Chunwei Huang, Yifan Xiao, Xiangyu Tang, Hao Li, Yongzhuang Ma, Jiyuan Yan, Weigang Li, Hua Wu and Chaoxu Liu Tags: Research Source Type: research

Generation of cortical neurons through large-scale expanding neuroepithelial stem cell from human pluripotent stem cells
Considerable progress has been made in converting human pluripotent stem cells (hPSCs) into cortical neurons for disease modeling and regenerative medicine. However, these procedures are hard to provide suffic... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 2, 2020 Category: Stem Cells Authors: Shumei Zhao, Kui Duan, Zongyong Ai, Baohua Niu, Yanying Chen, Ruize Kong and Tianqing Li Tags: Research Source Type: research

Stem cell therapies for periodontal tissue regeneration: a network meta-analysis of preclinical studies
Periodontal tissue regeneration (PTR) is the ultimate goal of periodontal therapy. Currently, stem cell therapy is considered a promising strategy for achieving PTR. However, there is still no conclusive compa... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 2, 2020 Category: Stem Cells Authors: Qiang Li, Guangwen Yang, Jialing Li, Meng Ding, Na Zhou, Heng Dong and Yongbin Mou Tags: Research Source Type: research

UBA2 activates Wnt/ β-catenin signaling pathway during protection of R28 retinal precursor cells from hypoxia by extracellular vesicles derived from placental mesenchymal stem cells
Stem cell transplantation has been proposed as an alternative treatment for intractable optic nerve disorders characterized by irrecoverable loss of cells. Mesenchymal stem cells, with varying tissue regenerat... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 2, 2020 Category: Stem Cells Authors: Kyungmin Koh, Mira Park, Eun Soo Bae, Van-An Duong, Jong-Moon Park, Hookeun Lee and Helen Lew Tags: Research Source Type: research

Acquisition of cancer stem cell properties in osteosarcoma cells by defined factors
Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity of CSCs in clinical samples makes it difficult to elucidate... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 2, 2020 Category: Stem Cells Authors: Shuichi Fujiwara, Teruya Kawamoto, Yohei Kawakami, Yasufumi Koterazawa, Hitomi Hara, Toshiyuki Takemori, Kazumichi Kitayama, Shunsuke Yahiro, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Michiyo Koyanagi-Aoi, Takashi Aoi, Tags: Research Source Type: research

Bronchioalveolar stem cells derived from mouse-induced pluripotent stem cells promote airway epithelium regeneration
Bronchioalveolar stem cells (BASCs) located at the bronchioalveolar-duct junction (BADJ) are stem cells residing in alveoli and terminal bronchioles that can self-renew and differentiate into alveolar type (AT... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 2, 2020 Category: Stem Cells Authors: Naoya Kawakita, Hiroaki Toba, Keiko Miyoshi, Shinichi Sakamoto, Daisuke Matsumoto, Mika Takashima, Mariko Aoyama, Seiya Inoue, Masami Morimoto, Takeshi Nishino, Hiromitsu Takizawa and Akira Tangoku Tags: Research Source Type: research

Mesenchymal stem/stromal cell quality control: validation of mixed lymphocyte reaction assay using flow cytometry according to ICH Q2(R1)
This study p... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 1, 2020 Category: Stem Cells Authors: Tess Nicotra, Aur élie Desnos, Justine Halimi, Hélène Antonot, Loïc Reppel, Thomas Belmas, Alice Freton, Floriane Stranieri, Miryam Mebarki, Jérôme Larghero, Audrey Cras and Lionel Faivre Tags: Research Source Type: research

Shedding light on the role of keratinocyte-derived extracellular vesicles on skin-homing cells
Extracellular vesicles (EVs) are secretory lipid membranes with the ability to regulate cellular functions by exchanging biological components between different cells. Resident skin cells such as keratinocytes... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 29, 2020 Category: Stem Cells Authors: Golara Nasiri, Negar Azarpira, Aliakbar Alizadeh, Sanaz Goshtasbi and Lobat Tayebi Tags: Review Source Type: research

Microparticles derived from human erythropoietin mRNA-transfected mesenchymal stem cells inhibit epithelial-to-mesenchymal transition and ameliorate renal interstitial fibrosis
Renal tubulointerstitial fibrosis (TIF) plays an important role in the progression of chronic kidney disease (CKD) and its pathogenesis involves epithelial-to-mesenchymal transition (EMT) upon renal injury. Re... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 29, 2020 Category: Stem Cells Authors: Mirae Lee, Seok-hyung Kim, Jong Hyun Jhee, Tae Yeon Kim, Hoon Young Choi, Hyung Jong Kim and Hyeong Cheon Park Tags: Research Source Type: research

Maternal sevoflurane exposure affects differentiation of hippocampal neural stem cells by regulating miR-410-3p and ATN1
Currently, numerous animal studies have shown that exposure to commonly used general anesthetics during pregnancy may cause neurocognitive impairment in the offspring. Reportedly, exposure to sevoflurane durin... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 29, 2020 Category: Stem Cells Authors: Yi Zhang, Ziyi Wu, Xingyue Li, Yuxiao Wan, Yinong Zhang and Ping Zhao Tags: Research Source Type: research

Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization
Mesenchymal stem cells (MSCs) are adult stromal cells that reside in virtually all postnatal tissues. Due to their regenerative and immunomodulatory capacities, MSCs have attracted growing attention during the... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 29, 2020 Category: Stem Cells Authors: Jiangmei Wang, Jie Xia, Ruoqiong Huang, Yaoqin Hu, Jiajie Fan, Qiang Shu and Jianguo Xu Tags: Review Source Type: research

Hepatic stellate cells contribute to liver regeneration through galectins in hepatic stem cell niche
As a critical cellular component in the hepatic stem cell niche, hepatic stellate cells (HSCs) play critical roles in regulating the expansion of hepatic stem cells, liver regeneration, and fibrogenesis. Howev... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 29, 2020 Category: Stem Cells Authors: Jian-Yun Ge, Yun-Wen Zheng, Tomonori Tsuchida, Kinji Furuya, Hiroko Isoda, Hideki Taniguchi, Nobuhiro Ohkohchi and Tatsuya Oda Tags: Research Source Type: research

Optical mapping of human embryonic stem cell-derived cardiomyocyte graft electrical activity in injured hearts
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) show tremendous promise for cardiac regeneration, but the successful development of hESC-CM-based therapies requires improved tools to investigate th... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 25, 2020 Category: Stem Cells Authors: Dominic Filice, Wahiba Dhahri, Joell L. Solan, Paul D. Lampe, Erin Steele, Nikita Milani, Benjamin Van Biber, Wei-Zhong Zhu, Tamilla Sadikov Valdman, Rocco Romagnolo, Jos é David Otero-Cruz, Kip D. Hauch, Matthew W. Kay, Narine Sarvazyan and Michael A. L Tags: Research Source Type: research

Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE
Mesenchymal stem cells (MSCs) have been recognized for their regenerative and anti-inflammatory capacity which makes them very attractive to cell therapy, especially those ones to treat inflammatory and autoim... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 25, 2020 Category: Stem Cells Authors: M ónica Kurte, Ana María Vega-Letter, Patricia Luz-Crawford, Farida Djouad, Danièle Noël, Maroun Khoury and Flavio Carrión Tags: Research Source Type: research

Immunosuppressive effects of mesenchymal stem cells on lung B cell gene expression in LPS-induced acute lung injury
In this study, we compared the changes in lung B cells dur... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 25, 2020 Category: Stem Cells Authors: Bing Feng, Jiaqi Zhu, Yanping Xu, Wenyi Chen, Xinyu Sheng, Xudong Feng, Xiaowei Shi, Jingqi Liu, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Lanjuan Li and Hongcui Cao Tags: Research Source Type: research

Therapeutic effect and safety of stem cell therapy for chronic liver disease: a systematic review and meta-analysis of randomized controlled trials
Stem cell therapy is becoming an emerging therapeutic option for chronic liver disease (CLD). However, whether stem cell therapy is more effective than conventional treatment remains questionable. We performed... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 25, 2020 Category: Stem Cells Authors: Guang-Peng Zhou, Yi-Zhou Jiang, Li-Ying Sun and Zhi-Jun Zhu Tags: Research Source Type: research

Long noncoding RNA H19 regulates the therapeutic efficacy of mesenchymal stem cells in rats with severe acute pancreatitis by sponging miR-138-5p and miR-141-3p
Patients with severe acute pancreatitis (SAP), which is characterized by high morbidity and mortality, account for an increasing medical burden worldwide. We previously found that mesenchymal stem cells (MSCs)... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 25, 2020 Category: Stem Cells Authors: Guodong Song, Jia Zhou, Ruimei Song, Dalu Liu, Weidi Yu, Wangcheng Xie, Zhilong Ma, Jian Gong, Hongbo Meng, Tingsong Yang and Zhenshun Song Tags: Research Source Type: research

Derivation and propagation of spermatogonial stem cells from human pluripotent cells
This study is designed to generate and propagate human spermatogonial stem cells (SSCs) derived from human pluripotent stem cells (hPSCs). (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 23, 2020 Category: Stem Cells Authors: Huiming Xu, Mengbo Yang, Ruhui Tian, Yonghui Wang, Linhong Liu, Zijue Zhu, Shi Yang, Qingqing Yuan, Minghui Niu, Chencheng Yao, Erlei Zhi, Peng Li, Chenhao Zhou, Zuping He, Zheng Li and Wei-Qiang Gao Tags: Research Source Type: research

Stepwise differentiation and functional characterization of human induced pluripotent stem cell-derived choroidal endothelial cells
Endothelial cells (ECs) are essential regulators of the vasculature, lining arteries, veins, and capillary beds. While all ECs share a number of structural and molecular features, heterogeneity exists dependin... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 23, 2020 Category: Stem Cells Authors: Kelly Mulfaul, Joseph C. Giacalone, Andrew P. Voigt, Megan J. Riker, Dalyz Ochoa, Ian C. Han, Edwin M. Stone, Robert F. Mullins and Budd A. Tucker Tags: Method Source Type: research

Human amniotic epithelial cells ameliorate kidney damage in ischemia-reperfusion mouse model of acute kidney injury
Acute kidney injury (AKI) is a common clinical disease with complex pathophysiology and limited therapeutic choices. This prompts the need for novel therapy targeting multiple aspects of this disease. Human am... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 23, 2020 Category: Stem Cells Authors: Yifei Ren, Ying Chen, Xizi Zheng, Hui Wang, Xin Kang, Jiawei Tang, Lei Qu, Xiaoyan Shao, Suxia Wang, Shuangling Li, Gang Liu and Li Yang Tags: Research Source Type: research

Peptidome analysis of umbilical cord mesenchymal stem cell (hUC-MSC) conditioned medium from preterm and term infants
The therapeutic role of mesenchymal stem cells (MSCs) has been widely confirmed in several animal models of premature infant diseases. Micromolecule peptides have shown promise for the treatment of premature i... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 23, 2020 Category: Stem Cells Authors: Yu Wang, Lin Zhang, Yun Wu, Rongping Zhu, Yan Wang, Yan Cao, Wei Long, Chenbo Ji, Huaiyan Wang and Lianghui You Tags: Research Source Type: research

Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth
Millions suffer from skin diseases. Functional interfollicular epidermal stem cells are needed in skin therapy or drug screening in vitro. We obtained functional interfollicular epidermal stem cells with intac... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 23, 2020 Category: Stem Cells Authors: Ling Leng, Jie Ma, Luye Lv, Wenjuan Wang, Dunqin Gao, Yunping Zhu and Zhihong Wu Tags: Short report Source Type: research

The role of mesenchymal stromal cells in immune modulation of COVID-19: focus on cytokine storm
The outbreak of coronavirus disease 2019 (COVID-19) pandemic is quickly spreading all over the world. This virus, which is called SARS-CoV-2, has infected tens of thousands of people. Based on symptoms, the pa... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - September 18, 2020 Category: Stem Cells Authors: Maria Kavianpour, Mahshid Saleh and Javad Verdi Tags: Review Source Type: research