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Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology
The production of veritable in-vitro models of bone tissue is essential to understand the biology of bone and its surrounding environment, to analyze the pathogenesis of bone diseases (e.g., osteoporosis, oste... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 20, 2018 Category: Stem Cells Authors: Alessandro Pirosa, Riccardo Gottardi, Peter G. Alexander and Rocky S. Tuan Tags: Review Source Type: research

Correction to: Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C
The original article [1] mistakenly omitted a source of funding, and the authors would like to rectify this by acknowledging the additional support of the Natural Science Foundation in Jiangsu Province (BK2015... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 19, 2018 Category: Stem Cells Authors: Zhaoyu Lin, Fei Liu, Peiliang Shi, Anying Song, Zan Huang, Dayuan Zou, Qin Chen, Jianxin Li and Xiang Gao Tags: Correction Source Type: research

Long noncoding RNA H19 upregulates vascular endothelial growth factor A to enhance mesenchymal stem cells survival and angiogenic capacity by inhibiting miR-199a-5p
Currently, the overall therapeutic efficiency of mesenchymal stem cells (MSCs) transplantation for the treatment of cardiovascular disease is not satisfactory. The low viability and angiogenic capacity of the ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 19, 2018 Category: Stem Cells Authors: Jingying Hou, Lingyun Wang, Quanhua Wu, Guanghui Zheng, Huibao Long, Hao Wu, Changqing Zhou, Tianzhu Guo, Tingting Zhong, Lei Wang, Xuxiang Chen and Tong Wang Tags: Research Source Type: research

Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats
Silicosis has been topping the list of high-incidence occupational diseases in developing countries and cannot be completely cured. Recent advances in stem cell research have made possible the treatment of var... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 19, 2018 Category: Stem Cells Authors: Shangya Chen, Guanqun Cui, Cheng Peng, Martin F. Lavin, Xiaoying Sun, Enguo Zhang, Ye Yang, Yingjun Guan, Zhongjun Du and Hua Shao Tags: Research Source Type: research

Effects of senolytic drugs on human mesenchymal stromal cells
Senolytic drugs are thought to target senescent cells and might thereby rejuvenate tissues. In fact, such compounds were suggested to increase health and lifespan in various murine aging models. So far, effect... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 18, 2018 Category: Stem Cells Authors: Clara Grezella, Eduardo Fernandez-Rebollo, Julia Franzen, M ónica Sofia Ventura Ferreira, Fabian Beier and Wolfgang Wagner Tags: Short report Source Type: research

Platelet-rich plasma enhances the proliferation of human adipose stem cells through multiple signaling pathways
Platelet-rich plasma (PRP) is an autologous blood product that contains a high concentration of several growth factors. Platelet-derived growth factor (PDGF)-BB is a potential mitogen for human adipose-derived... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 16, 2018 Category: Stem Cells Authors: Fangyuan Lai, Natsuko Kakudo, Naoki Morimoto, Shigeru Taketani, Tomoya Hara, Takeshi Ogawa and Kenji Kusumoto Tags: Research Source Type: research

The emerging role of fibrocytes in ocular disorders
The fibrocyte, which was first described in 1994, is a type of circulating mesenchymal progenitor cell in the peripheral blood. Fibrocytes play important roles in chronic inflammation, wound healing, tissue re... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 13, 2018 Category: Stem Cells Authors: Feng Zhang, Ke Liu, Han Zhao and Yan He Tags: Review Source Type: research

Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury
Damage of mitochondria in the initial period of tissue injury aggravates the severity of injury. Restoration of mitochondria dysfunction and mitochondrial-based therapeutics represent a potentially effective t... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 13, 2018 Category: Stem Cells Authors: Jingyu Wang, Heyangzi Li, Ying Yao, Tengfei Zhao, Ying-ying Chen, Yue-liang Shen, Lin-lin Wang and Yongjian Zhu Tags: Review Source Type: research

Three-dimensional printed PLA scaffold and human gingival stem cell-derived extracellular vesicles: a new tool for bone defect repair
The role of bone tissue engineering in the field of regenerative medicine has been a main research topic over the past few years. There has been much interest in the use of three-dimensional (3D) engineered sc... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 13, 2018 Category: Stem Cells Authors: Francesca Diomede, Agnese Gugliandolo, Paolo Cardelli, Ilaria Merciaro, Valeria Ettorre, Tonino Traini, Rossella Bedini, Domenico Scionti, Alessia Bramanti, Antonio Nanci, Sergio Caputi, Antonella Fontana, Emanuela Mazzon and Oriana Trubiani Tags: Research Source Type: research

Characterization of the interaction between human decidua parietalis mesenchymal stem/stromal cells and natural killer cells
Human decidua parietalis mesenchymal stem/multipotent stromal cells (DPMSCs) have unique phenotypic and functional properties that make them promising candidates for cell-based therapy. Here, we investigated DPMS... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 12, 2018 Category: Stem Cells Authors: M. H. Abumaree, E. Bahattab, A. Alsadoun, A. Al Dosaimani, F. M. Abomaray, T. Khatlani, B. Kalionis, M. F. El-Muzaini, A. O. Alawad and A. S. AlAskar Tags: Research Source Type: research

Dental pulp stem cells used to deliver the anticancer drug paclitaxel
Understanding stem cell behavior as a delivery tool in cancer therapy is essential for evaluating their future clinical potential. Previous in-vivo studies proved the use of mesenchymal stem cells (MSCs) for l... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 12, 2018 Category: Stem Cells Authors: Hamideh Salehi, Siham Al-Arag, Elodie Middendorp, Csilla Gergely, Frederic Cuisinier and Valerie Orti Tags: Research Source Type: research

Human amnion-derived mesenchymal stem cells alleviate lung injury induced by white smoke inhalation in rats
White smoke inhalation (WSI) is an uncommon but potentially deadly cause of acute lung injury and acute respiratory distress syndrome for which no effective pharmaceutical treatment has been developed. This st... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 12, 2018 Category: Stem Cells Authors: Pei Cui, Haiming Xin, Yongming Yao, Shichu Xiao, Feng Zhu, Zhenyu Gong, Zhiping Tang, Qiu Zhan, Wei Qin, Yanhua Lai, Xiaohui Li, Yalin Tong and Zhaofan Xia Tags: Research Source Type: research

Impact of bone marrow mesenchymal stem cell immunomodulation on the osteogenic effects of laponite
With the development of osteoimmunology and bone tissue engineering (BTE), it has been recognized that the immunomodulatory properties of bone biomaterials have considerable impact in determining their fate af... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 11, 2018 Category: Stem Cells Authors: Tao Li, Zhong Long Liu, Ming Xiao, Ze Zheng Yang, Ming Zheng Peng, Cui Di Li, Xiao Jun Zhou and Jin Wu Wang Tags: Research Source Type: research

Efficacy and long-term longitudinal follow-up of bone marrow mesenchymal cell transplantation therapy in a diabetic patient with recurrent lower limb bullosis diabeticorum
Bullosis diabeticorum is a rare presentation of cutaneous manifestation most commonly affecting the lower limbs in patients with diabetes. The appearance, often as insidious as its resolution, is characterized... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 10, 2018 Category: Stem Cells Authors: Yan Chen, Yu Ma, Ning Li, Hongyan Wang, Bing Chen, Ziwen Liang, Rui Ren, Debin Lu, Johnson Boey, David G. Armstrong and Wuquan Deng Tags: Short report Source Type: research

Histone hypo-acetylation of Sox9 mediates nicotine-induced weak cartilage repair by suppressing BMSC chondrogenic differentiation
Nicotine has negative effects on tissue repair, little research concerns its effect on the cartilage repair of tissue engineering stem cells. The present study aimed to investigate the effects of nicotine on t... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 10, 2018 Category: Stem Cells Authors: Kai Tie, Min Wu, Yu Deng, Yinxian Wen, Dan Xu, Liaobin Chen and Hui Wang Tags: Research Source Type: research

Endoscopic submucosal injection of adipose-derived mesenchymal stem cells ameliorates TNBS-induced colitis in rats and prevents stenosis
Mesenchymal stem cells have potential applications in inflammatory bowel disease due to their immunomodulatory properties. Our aim was to evaluate the feasibility, safety and efficacy of endoscopic administrat... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 10, 2018 Category: Stem Cells Authors: Eduardo Mart ín Arranz, María Dolores Martín Arranz, Tomás Robredo, Pablo Mancheño-Corvo, Ramón Menta, Francisco Javier Alves, Jose Manuel Suárez de Parga, Pedro Mora Sanz, Olga de la Rosa, Dirk Büscher, Eleuterio Lombardo and Fernando de Miguel Tags: Research Source Type: research

Safety and tracking of intrathecal allogeneic mesenchymal stem cell transplantation in healthy and diseased horses
It is currently unknown if the intrathecal administration of a high dose of allogeneic mesenchymal stem cells (MSCs) is safe, how MSCs migrate throughout the vertebral canal after intrathecal administration, a... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 10, 2018 Category: Stem Cells Authors: Danielle Jaqueta Barberini, Monica Aleman, Fabio Aristizabal, Mathieu Spriet, Kaitlin C. Clark, Naomi J. Walker, Larry D. Galuppo, Rog ério Martins Amorim, Kevin D. Woolard and Dori L. Borjesson Tags: Research Source Type: research

Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage
Commitment of pluripotent stem cells into differentiated cells and associated gene expression necessitate specific epigenetic mechanisms that modify the DNA and corresponding histone proteins to render the chr... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 10, 2018 Category: Stem Cells Authors: Varsha Pursani, Deepa Bhartiya, Vivek Tanavde, Mohsin Bashir and Prabha Sampath Tags: Research Source Type: research

Temporomandibular joint regeneration: proposal of a novel treatment for condylar resorption after orthognathic surgery using transplantation of autologous nasal septum chondrocytes, and the first human case report
Upon orthognathic mandibular advancement surgery the adjacent soft tissues can displace the distal bone segment and increase the load on the temporomandibular joint causing loss of its integrity. Remodeling of... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 7, 2018 Category: Stem Cells Authors: Ricardo de Souza Tesch, Esther Rieko Takamori, Karla Menezes, Rosana Bizon Vieira Carias, Cl áudio Leonardo Milione Dutra, Marcelo de Freitas Aguiar, Tânia Salgado de Sousa Torraca, Alexandra Cristina Senegaglia, Cármen Lúcia Kuniyoshi Rebelatto, Debo Tags: Research Source Type: research

Evaluation of the effects of ascorbic acid on metabolism of human mesenchymal stem cells
Mesenchymal stem cells (MSCs) are multipotent cells holding much promise for applications in regenerative medicine. However, with problems such as aging, increases in heteroploid cells, genomic instability, an... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2018 Category: Stem Cells Authors: Koichi Fujisawa, Kazusa Hara, Taro Takami, Sae Okada, Toshihiko Matsumoto, Naoki Yamamoto and Isao Sakaida Tags: Research Source Type: research

Targeted genome engineering in human induced pluripotent stem cells from patients with hemophilia B using the CRISPR-Cas9 system
Replacement therapy for hemophilia remains a lifelong treatment. Only gene therapy can cure hemophilia at a fundamental level. The clustered regularly interspaced short palindromic repeats –CRISPR associated nu... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2018 Category: Stem Cells Authors: Cuicui Lyu, Jun Shen, Rui Wang, Haihui Gu, Jianping Zhang, Feng Xue, Xiaofan Liu, Wei Liu, Rongfeng Fu, Liyan Zhang, Huiyuan Li, Xiaobing Zhang, Tao Cheng, Renchi Yang and Lei Zhang Tags: Research Source Type: research

Intramuscular transplantation of bone marrow cells prolongs the lifespan of SOD1G93A mice and modulates expression of prognosis biomarkers of the disease
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive muscle weakness, paralysis and death. There is no effective treatment for ALS and stem cell therapy has arisen a... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2018 Category: Stem Cells Authors: Amaya Rando, Diego Pastor, Mari Carmen Viso-Le ón, Anna Martínez, Raquel Manzano, Xavier Navarro, Rosario Osta and Salvador Martínez Tags: Research Source Type: research

TSG-6 released from intraperitoneally injected canine adipose tissue-derived mesenchymal stem cells ameliorate inflammatory bowel disease by inducing M2 macrophage switch in mice
Inflammatory bowel disease (IBD) is an intractable autoimmune disorder that markedly deteriorates one ’s quality of life. Mesenchymal stem cells (MSCs) alleviate inflammation by modulating inflammatory cytokine... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2018 Category: Stem Cells Authors: Woo-Jin Song, Qiang Li, Min-Ok Ryu, Jin-Ok Ahn, Dong Ha Bhang, Yun Chan Jung and Hwa-Young Youn Tags: Research Source Type: research

MeCP2-mediated epigenetic regulation in senescent endothelial progenitor cells
Cellular aging may be associated with epigenetics. Methyl-CpG-binding protein 2 (MeCP2) and sirtuin 1 (SIRT1) are two important epigenetic factors. Our former work demonstrated that MeCP2 expression increased ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 3, 2018 Category: Stem Cells Authors: Chunli Wang, Fei Wang, Zhen Li, Qing Cao, Liya Huang and Shuyan Chen Tags: Research Source Type: research

Human chorionic plate-derived mesenchymal stem cells transplantation restores ovarian function in a chemotherapy-induced mouse model of premature ovarian failure
Previous studies have reported that transplantation of mesenchymal stem cells (MSCs) from many human tissues could ameliorate ovarian dysfunction. However, no study has revealed the therapeutic efficiency of M... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 3, 2018 Category: Stem Cells Authors: Jun Li, Qingtong Yu, Haisen Huang, Wenwen Deng, Xia Cao, Michael Adu-Frimpong, Jiangnan Yu and Ximing Xu Tags: Research Source Type: research

Multimodal label-free imaging of living dermal equivalents including dermal papilla cells
Despite the significant progress in the development of skin equivalents (SEs), the problem of noninvasively assessing the quality of the cell components and the collagen structure of living SEs both before and... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 3, 2018 Category: Stem Cells Authors: Aleksandra V. Meleshina, Olga S. Rogovaya, Varvara V. Dudenkova, Marina A. Sirotkina, Maria M. Lukina, Alena S. Bystrova, Victoria G. Krut, Daria S. Kuznetsova, Ekaterina P. Kalabusheva, Andrey V. Vasiliev, Ekaterina A. Vorotelyak and Elena V. Zagaynova Tags: Research Source Type: research

TBX21 predicts prognosis of patients and drives cancer stem cell maintenance via the TBX21 –IL-4 pathway in lung adenocarcinoma
The Th1 cell-specific transcription factor TBX21 functions as a regulator of expression of a Th1 cytokine, interferon gamma (IFN- γ). However, the specific function of TBX21 correlated with cancer stemness rema... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 3, 2018 Category: Stem Cells Authors: Shuangtao Zhao, Wenzhi Shen, Jiangyong Yu and Luhua Wang Tags: Research Source Type: research

Influence of cholesterol/caveolin-1/caveolae homeostasis on membrane properties and substrate adhesion characteristics of adult human mesenchymal stem cells
Adult mesenchymal stem cells (MSCs) are an important resource for tissue growth, repair, and regeneration. To utilize MSCs more effectively, a clear understanding of how they react to environmental cues is ess... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 3, 2018 Category: Stem Cells Authors: Jihee Sohn, Hang Lin, Madalyn Rose Fritch and Rocky S. Tuan Tags: Research Source Type: research

High-sensitivity virus and mycoplasma screening test reveals high prevalence of parvovirus B19 infection in human synovial tissues and bone marrow
Latent microorganism infection is a safety concern for the clinical application of mesenchymal stem cells (MSCs). The aim of this study is to investigate the frequencies and sensitivities of the latent virus a... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 27, 2018 Category: Stem Cells Authors: Ken Watanabe, Koji Otabe, Norio Shimizu, Keiichirou Komori, Mitsuru Mizuno, Hisako Katano, Hideyuki Koga and Ichiro Sekiya Tags: Research Source Type: research

The need to revisit the definition of mesenchymal and adult stem cells based on their functional attributes
A debate is ongoing about the ‘stem cell’ status of mesenchymal stem cells (MSCs). This can easily be resolved based on the definition of a stem cell. ‘True’ stem cells are expected to undergo asymmetric cell ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 27, 2018 Category: Stem Cells Authors: Deepa Bhartiya Tags: Viewpoint Source Type: research

Repair of bone defects in rat radii with a composite of allogeneic adipose-derived stem cells and heterogeneous deproteinized bone
In this study, the feasibility of using allogeneic adipose-derived stem cells(ADSCs) combined with he... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 27, 2018 Category: Stem Cells Authors: Jia Liu, Peng Zhou, Yu Long, Chunxia Huang and Danna Chen Tags: Research Source Type: research

Engineering a multicellular vascular niche to model hematopoietic cell trafficking
The marrow microenvironment and vasculature plays a critical role in regulating hematopoietic cell recruitment, residence, and maturation. Extensive in vitro and in vivo studies have aimed to understand the marro... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 23, 2018 Category: Stem Cells Authors: Surya S. Kotha, Brian J. Hayes, Kiet T. Phong, Meredith A. Redd, Karol Bomsztyk, Aravind Ramakrishnan, Beverly Torok-Storb and Ying Zheng Tags: Research Source Type: research

Correction to: Human umbilical cord mesenchymal stem cell conditioned medium attenuates renal fibrosis by reducing inflammation and epithelial-to-mesenchymal transition via the TLR4/NF- κB signaling pathway in vivo and in vitro
The original article [1] contains an error whereby the corresponding authorship is mistakenly designated to the author Fengxia Ding. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 22, 2018 Category: Stem Cells Authors: Bo Liu, Fengxia Ding, Dong Hu, Yu Zhou, Chunlan Long, Lianju Shen, Yuanyuan Zhang, Deying Zhang and Guanghui Wei Tags: Correction Source Type: research

Platelet lysate as a novel serum-free media supplement for the culture of equine bone marrow-derived mesenchymal stem cells
Mesenchymal stem cells (MSCs) produced for clinical purposes rely on culture media containing fetal bovine serum (FBS) which is xenogeneic and has the potential to significantly alter the MSC phenotype, render... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 22, 2018 Category: Stem Cells Authors: Maria C. Naskou, Scarlett M. Sumner, Anna Chocallo, Hannah Kemelmakher, Merrilee Thoresen, Ian Copland, Jacques Galipeau and John F. Peroni Tags: Research Source Type: research

Stem cell properties of human clonal salivary gland stem cells are enhanced by three-dimensional priming culture in nanofibrous microwells
Three-dimensional (3D) cultures recapitulate the microenvironment of tissue-resident stem cells and enable them to modulate their properties. We determined whether salivary gland-resident stem cells (SGSCs) ar... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 22, 2018 Category: Stem Cells Authors: Hyun-Soo Shin, Songyi Lee, Hye Jin Hong, Young Chang Lim, Won-Gun Koh and Jae-Yol Lim Tags: Research Source Type: research

Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells
The regulatory role of long noncoding RNAs (lncRNAs) have been partially proved in embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 21, 2018 Category: Stem Cells Authors: Jiajie Tu, Geng Tian, Hoi-Hung Cheung, Wei Wei and Tin-lap Lee Tags: Research Source Type: research

A pooled analysis of mesenchymal stem cell-based therapy for liver disease
Liver disease is a major cause of death and disability. Mesenchymal stem cells (MSCs) show promise for the treatment of liver disease. However, whether MSC-based therapy is more effective than conventional tre... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 21, 2018 Category: Stem Cells Authors: Lu Zhao, Shanquan Chen, Xiaowei Shi, Hongcui Cao and Lanjuan Li Tags: Review Source Type: research

Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration
Three-dimensional (3D) cultured clumps of mesenchymal stem cell (MSC)/extracellular matrix (ECM) complexes (C-MSCs) consist of cells and self-produced ECM. C-MSCs can regulate cellular functions in vitro and c... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 21, 2018 Category: Stem Cells Authors: Souta Motoike, Mikihito Kajiya, Nao Komatsu, Manabu Takewaki, Susumu Horikoshi, Shinji Matsuda, Kazuhisa Ouhara, Tomoyuki Iwata, Katsuhiro Takeda, Tsuyoshi Fujita and Hidemi Kurihara Tags: Research Source Type: research

Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis
Induced pluripotent stem-cell derived endothelial cells (iPSC-ECs) can be generated from any somatic cell and their iPSC sources possess unlimited self-renewal. Previous demonstration of their proangiogenic ac... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 21, 2018 Category: Stem Cells Authors: Richard P. Tan, Alex H. P. Chan, Katarina Lennartsson, Maria M. Miravet, Bob S. L. Lee, Jelena Rnjak-Kovacina, Zoe E. Clayton, John P. Cooke, Martin K. C. Ng, Sanjay Patel and Steven G. Wise Tags: Research Source Type: research

Human dental pulp stromal cell conditioned medium alters endothelial cell behavior
Angiogenesis is of utmost importance for tissue regeneration and repair. Human dental pulp stromal cells (hDPSCs) possess angiogenic potential, as they secrete paracrine factors that may alter the host microen... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 21, 2018 Category: Stem Cells Authors: M. A. Gharaei, Y. Xue, K. Mustafa, S. A. Lie and I. Fristad Tags: Research Source Type: research

Amenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming
While a shift towards non-viral and animal component-free methods of generating induced pluripotent stem (iPS) cells is preferred for safer clinical applications, there is still a shortage of reliable cell sou... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 20, 2018 Category: Stem Cells Authors: Srijaya Thekkeparambil Chandrabose, Sandhya Sriram, Subha Subramanian, Shanshan Cheng, Wee Kiat Ong, Steve Rozen, Noor Hayaty Abu Kasim and Shigeki Sugii Tags: Research Source Type: research

Highly efficient methods to obtain homogeneous dorsal neural progenitor cells from human and mouse embryonic stem cells and induced pluripotent stem cells
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been widely used to generate cellular models harboring specific disease-related genotypes. Of particular importance are ESC and iPSC ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 15, 2018 Category: Stem Cells Authors: Meixiang Zhang, Justine Ngo, Filomena Pirozzi, Ying-Pu Sun and Anthony Wynshaw-Boris Tags: Method Source Type: research

Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway
Mesenchymal stem cells derived from gingiva (GMSCs) display profound immunomodulation properties in addition to self-renewal and multilineage differentiation capacities. Hydrogen sulfide (H2S) is not only an envi... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 9, 2018 Category: Stem Cells Authors: Ruili Yang, Tingting Yu, Dawei Liu, Songtao Shi and Yanheng Zhou Tags: Research Source Type: research

Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis
Nowadays, orthotopic liver transplantation is considered the most efficient approach to the end stage of chronic hepatic cirrhosis. Because of the limitations of orthotopic liver transplantation, stem cells ar... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 9, 2018 Category: Stem Cells Authors: Yongting Zhang, Yuwen Li, Lili Zhang, Jun Li and Chuanlong Zhu Tags: Review Source Type: research

Autologous chyle fat grafting for the treatment of hypertrophic scars and scar-related conditions
Scarring is the product of natural restoration, yet its treatment remains challenging. Both collagen and fibroblasts are abnormally abundant in scars, leading to scar hyperplasia or contracture. Several clinic... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 9, 2018 Category: Stem Cells Authors: Xiao Xu, Linying Lai, Xuyi Zhang, Jinhong Chen, Junnan Chen, Fei Wang, Jingchen Zheng and Minliang Chen Tags: Research Source Type: research

Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes
Circular RNAs (circRNAs) are regarded as a novel class of noncoding RNA regulators. Although a number of circRNAs have been identified by bioinformatics analysis of RNA-seq data, tissue and disease-specific ci... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 9, 2018 Category: Stem Cells Authors: Wei Lei, Tingting Feng, Xing Fang, You Yu, Junjie Yang, Zhen-Ao Zhao, Junwei Liu, Zhenya Shen, Wenbo Deng and Shijun Hu Tags: Research Source Type: research

Human amniotic mesenchymal stem cells improve ovarian function in natural aging through secreting hepatocyte growth factor and epidermal growth factor
Although many reports show that various kinds of stem cells have the ability to recover function in premature ovarian aging, few studies have looked at stem cell treatment of natural ovarian aging (NOA). We de... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 9, 2018 Category: Stem Cells Authors: Chenyue Ding, Qinyan Zou, Fuxin Wang, Huihua Wu, Rulei Chen, Jinghuan Lv, Mingfa Ling, Jian Sun, Wei Wang, Hong Li and Boxian Huang Tags: Research Source Type: research

Pharmacological activation of TAZ enhances osteogenic differentiation and bone formation of adipose-derived stem cells
Adipose-derived stem cells (ADSCs) are an attractive cell source for bone tissue engineering and have great potential for bone regeneration and defect repair. The transcriptional coactivator with PDZ-binding m... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 7, 2018 Category: Stem Cells Authors: Yumin Zhu, Yaping Wu, Jie Cheng, Qiong Wang, Zhongwu Li, Yanling Wang, Dongmiao Wang, Hua Wang, Weibing Zhang, Jinhai Ye, Hongbing Jiang and Lin Wang Tags: Research Source Type: research

Extracellular matrix stiffness controls osteogenic differentiation of mesenchymal stem cells mediated by integrin α5
Human mesenchymal stem cell (hMSC) differentiation into osteoblasts has important clinical significance in treating bone injury, and the stiffness of the extracellular matrix (ECM) has been shown to be an impo... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 1, 2018 Category: Stem Cells Authors: Meiyu Sun, Guangfan Chi, Juanjuan Xu, Ye Tan, Jiayi Xu, Shuang Lv, Ziran Xu, Yuhan Xia, Lisha Li and Yulin Li Tags: Research Source Type: research

Human mesenchymal stem cells in spheroids improve fertility in model animals with damaged endometrium
Asherman ’s syndrome (AS) is one of the gynecological disorders caused by the destruction of the endometrium. For some cases of AS available surgical methods and hormonal therapy are ineffective. Stem cell tran... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 26, 2018 Category: Stem Cells Authors: Alisa Domnina, Polina Novikova, Julia Obidina, Irina Fridlyanskaya, Larisa Alekseenko, Irina Kozhukharova, Olga Lyublinskaya, Valeriy Zenin and Nikolay Nikolsky Tags: Research Source Type: research