Injury-induced fetal reprogramming imparts multipotency and reparative properties to pericardial adipose stem cells
Injury may induce a sequential activation of intrinsic reparative activity that supports the maintenance of tissue homeostasis. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - August 13, 2018 Category: Stem Cells Authors: Jianfeng Tang, Xiaoming Wang, Kezhe Tan, Hongtao Zhu, Youming Zhang, Weili Ouyang, Xueqing Liu and Zhaoping Ding Tags: Research Source Type: research

Establishment of a complex skin structure via layered co-culture of keratinocytes and fibroblasts derived from induced pluripotent stem cells
Skin is an organ that plays an important role as a physical barrier and has many other complex functions. Skin mimetics may be useful for studying the pathophysiology of diseases in vitro and for repairing les... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - August 13, 2018 Category: Stem Cells Authors: Yena Kim, Narae Park, Yeri Alice Rim, Yoojun Nam, Hyerin Jung, Kijun Lee and Ji Hyeon Ju Tags: Research Source Type: research

The role of the Wnt/ β-catenin signaling pathway in the proliferation of gold nanoparticle-treated human periodontal ligament stem cells
Several studies have confirmed that gold nanoparticles (AuNPs) of specific concentration and size exert a boosting effect on cell proliferation; however, the mechanism through which this effect occurs remains ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - August 9, 2018 Category: Stem Cells Authors: Chen Li, Zhuoquan Li, Yan Zhang, Abdel Hamid Fathy and Min Zhou Tags: Research Source Type: research

Development and characterization of a polarized human endometrial cell epithelia in an air –liquid interface state
Human endometrial epithelia undergo injury repair and regeneration with the menstrual cycle; however, mechanisms underpinning the roles of endometrial epithelial cells in endometrial lesions and regeneration r... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - August 9, 2018 Category: Stem Cells Authors: Dandan Li, Hui Li, Ying Wang, Ahmed Eldomany, Jing Wu, Chao Yuan, Jing Xue, Juan Shi, Yuanyuan Jia, Chunfang Ha, Shuxia Han, Xiaoming Liu, Jiali Yang and Dan Liu Tags: Short report Source Type: research

Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD
Although many reports show that various kinds of stem cells have the ability to recover the function of premature ovarian insufficiency (POI), few studies are associated with the mechanism of stem cell treatme... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - August 9, 2018 Category: Stem Cells Authors: Boxian Huang, Jiafeng Lu, Chenyue Ding, Qinyan Zou, Wei Wang and Hong Li Tags: Research Source Type: research

Histone demethylase JMJD6 regulates cellular migration and proliferation in adipose-derived mesenchymal stem cells
Adipose-derived mesenchymal stem cells (ADSCs) have been extensively explored as a promising therapeutic agent due to their differentiation, proliferation and migration abilities. The epigenetic mechanisms tha... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - August 9, 2018 Category: Stem Cells Authors: Chongyang Shen, Qingli Quan, Chuan Yang, Yueqiang Wen and Hong Li Tags: Research Source Type: research

Analysis of differentially expressed genes among human hair follicle –derived iPSCs, induced hepatocyte-like cells, and primary hepatocytes
Differentiation of human induced pluripotent stem cells (hiPSCs) into hepatocytes has important clinical significance in providing a new stem cell source for cell therapy of terminal liver disease. The differe... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - August 9, 2018 Category: Stem Cells Authors: Ziran Xu, Xia He, Xu Shi, Yuhan Xia, Xiaomei Liu, Haitao Wu, Pengdong Li, Hongyu Zhang, Weisi Yin, Xiubo Du, Lisha Li and Yulin Li Tags: Research Source Type: research

Single-molecule fluorescence in-situ hybridization reveals that human SHANK3 mRNA expression varies during development and in autism-associated SHANK3 heterozygosity
Deletions and mutations in the SHANK3 gene are strongly associated with autism spectrum disorder and underlie the autism-associated disorder Phelan –McDermid syndrome. SHANK3 is a scaffolding protein found at the ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 31, 2018 Category: Stem Cells Authors: Samuel E. Taylor, Ruth D. Taylor, Jack Price and Laura C. Andreae Tags: Research Source Type: research

Autologous adipose-derived stromal vascular fraction and scarred vocal folds: first clinical case report
Patients with scarred vocal folds (congenitally or following phonosurgery) are currently difficult to treat and present a dysphonia, often disabling in daily life. Several therapies are available on the market... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 27, 2018 Category: Stem Cells Authors: Alexia Mattei, J érémy Magalon, Baptiste Bertrand, Fanny Grimaud, Joana Revis, Mélanie Velier, Julie Veran, Patrick Dessi, Florence Sabatier and Antoine Giovanni Tags: Short report Source Type: research

Tracking embryonic hematopoietic stem cells to the bone marrow: nanoparticle options to evaluate transplantation efficiency
As the prevalence of therapeutic approaches involving transplanted cells increases, so does the need to noninvasively track the cells to determine their homing patterns. Of particular interest is the fate of t... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 27, 2018 Category: Stem Cells Authors: Sean K. Sweeney, Gohar S. Manzar, Nicholas Zavazava and Jose G. Assouline Tags: Research Source Type: research

The march of pluripotent stem cells in cardiovascular regenerative medicine
Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past d... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 27, 2018 Category: Stem Cells Authors: Haissam Abou-Saleh, Fouad A. Zouein, Ahmed El-Yazbi, Despina Sanoudou, Christophe Raynaud, Christopher Rao, Gianfranco Pintus, Hassan Dehaini and Ali H. Eid Tags: Review Source Type: research

Biphasic modulation of insulin signaling enables highly efficient hematopoietic differentiation from human pluripotent stem cells
Hematopoietic lineage cells derived from human pluripotent stem cells (hPSCs) hold great promise for the treatment of hematological diseases and providing sufficient cells for immune therapy. However, a simple... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 27, 2018 Category: Stem Cells Authors: Fuyu Duan, Rujin Huang, Fengzhi Zhang, Yonglin Zhu, Lin Wang, Xia Chen, Lufeng Bai, Wei Guo, Sophia Chia-Ning Chang, Xiaoyu Hu and Jie Na Tags: Research Source Type: research

In vitro osteoblastic differentiation of mesenchymal stem cells generates cell layers with distinct properties
Differentiation of mesenchymal stem cells to osteoblasts is widely performed in research laboratories. Classical tests to prove this differentiation employ procedures such as cell fixation, cell lysis or cell ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 27, 2018 Category: Stem Cells Authors: Hanna Hanna, Lluis M. Mir and Franck M. Andre Tags: Research Source Type: research

Bone marrow derived mesenchymal stem cells ameliorate inflammatory response in an in vitro model of familial hemophagocytic lymphohistiocytosis 2
Familial hemophagocytic lymphohistiocytosis 2 (FHL2) is the most common familial type of hemophagocytic lymphohistiocytosis with immune dysregulation. FHL2 patients have mutations in the perforin gene which ca... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 18, 2018 Category: Stem Cells Authors: Handan Sevim, Yusuf Çetin Kocaefe, Mehmet Ali Onur, Duygu Uçkan-Çetinkaya and Özer Aylin Gürpınar Tags: Research Source Type: research

Previously claimed male germline stem cells from porcine testis are actually progenitor Leydig cells
Male germline stem cells (mGSCs) offer great promise in regenerative medicine and animal breeding due to their capacity to maintain self-renewal and to transmit genetic information to the next generation follo... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 18, 2018 Category: Stem Cells Authors: Yinshan Bai, Cui Zhu, Meiying Feng, Hengxi Wei, Li Li, Xiuchun Tian, Zhihong Zhao, Shanshan Liu, Ningfang Ma, Xianwei Zhang, Ruyi Shi, Chao Fu, Zhenfang Wu and Shouquan Zhang Tags: Research Source Type: research

Is exclusion of leukocytes from platelet-rich plasma (PRP) a better choice for early intervertebral disc regeneration?
Platelet-rich plasma (PRP) is becoming a promising strategy to treat early intervertebral disc degeneration (IDD) in clinics. Pure PRP without leukocytes (P-PRP) may decrease the catabolic and inflammatory cha... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 18, 2018 Category: Stem Cells Authors: Shan-zheng Wang, Wei-min Fan, Jun Jia, Liang-yu Ma, Jia-bin Yu and Chen Wang Tags: Research Source Type: research

Role of Notch1 in the arterial specification and angiogenic potential of mouse embryonic stem cell-derived endothelial cells
Endothelial cells have been shown to mediate angiogenesis in ischemic injury sites and contribute to the repair of damaged tissues. However, the treatment of ischemic disease requires a significant number of e... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 18, 2018 Category: Stem Cells Authors: Jae Kyung Park, Tae Wook Lee, Eun Kyoung Do, Hye Ji Moon and Jae Ho Kim Tags: Research Source Type: research

The role of mesenchymal stem cells in chemotherapy-induced gonadotoxicity
The therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) against cisplatin-induced nephrotoxicity has been reported, however, its efficacy in gonadotoxicity still has not been addresse... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 18, 2018 Category: Stem Cells Authors: Iman O. Sherif, Dina Sabry, Azza Abdel-Aziz and Osama M. Sarhan Tags: Research Source Type: research

Autologous transplantation of adipose-derived stem cells improves functional recovery of skeletal muscle without direct participation in new myofiber formation
Skeletal muscle has a remarkable regenerative capacity. However, extensive damage that exceeds the self-regenerative ability of the muscle can lead to irreversible fibrosis, scarring, and significant loss of f... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 17, 2018 Category: Stem Cells Authors: Agata Gorecka, Souzan Salemi, Deana Haralampieva, Federica Moalli, Deborah Stroka, Daniel Candinas, Daniel Eberli and Lukas Br ügger Tags: Research Source Type: research

Thrombopoietin knock-in augments platelet generation from human embryonic stem cells
Refinement of therapeutic-scale platelet production in vitro will provide a new source for transfusion in patients undergoing chemotherapy or radiotherapy. However, procedures for cost-effective and scalable p... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 17, 2018 Category: Stem Cells Authors: Leisheng Zhang, Cuicui Liu, Hongtao Wang, Dan Wu, Pei Su, Mengge Wang, Jiaojiao Guo, Shixuan Zhao, Shuxu Dong, Wen Zhou, Cameron Arakaki, Xiaobing Zhang and Jiaxi Zhou Tags: Research Source Type: research

Exosomes from acellular Wharton ’s jelly of the human umbilical cord promotes skin wound healing
Compromised wound healing has become a global public health challenge which presents a significant psychological, financial, and emotional burden on patients and physicians. We recently reported that acellular... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 13, 2018 Category: Stem Cells Authors: Nazihah Bakhtyar, Marc G. Jeschke, Elaine Herer, Mohammadali Sheikholeslam and Saeid Amini-Nik Tags: Research Source Type: research

Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids
Organoids from human pluripotent stem cells are becoming suitable models for studies of organ development, drug screening, regenerative medicine, and disease modeling. Three-dimensional minilungs in Matrigel c... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 11, 2018 Category: Stem Cells Authors: Esmeralda Magro-Lopez, Charlotte Palmer, Joana Manso, Isabel Liste and Alberto Zambrano Tags: Short report Source Type: research

Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis
Exosomes are nano-sized vesicles (30 –200 nm) constantly released by almost all cells. The ability of exosomes to travel between cells and deliver their cargo, which includes lipids, proteins, and nucleic acids... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 11, 2018 Category: Stem Cells Authors: Byong Seung Cho, Jin Ock Kim, Dae Hyun Ha and Yong Weon Yi Tags: Letter Source Type: research

The establishment of a chemically defined serum-free culture system for human dental pulp stem cells
The concept of establishing a dental stem cell (DSC) bank for oral and maxillofacial regeneration has become of great interest but it remains at a primitive stage. The routine application of serum-containing c... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 11, 2018 Category: Stem Cells Authors: Jingyi Xiao, Dawei Yang, Qiwen Li, Weidong Tian and Weihua Guo Tags: Research Source Type: research

Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research
Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU oc... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 11, 2018 Category: Stem Cells Authors: Lara Lopes, Ocean Setia, Afsha Aurshina, Shirley Liu, Haidi Hu, Toshihiko Isaji, Haiyang Liu, Tun Wang, Shun Ono, Xiangjiang Guo, Bogdan Yatsula, Jianming Guo, Yongquan Gu, Tulio Navarro and Alan Dardik Tags: Research Source Type: research

Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial
Intrauterine adhesions (IUA) are the most common cause of uterine infertility and are caused by endometrium fibrotic regeneration following severe damage to the endometrium. Although current stem cell treatmen... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 11, 2018 Category: Stem Cells Authors: Yun Cao, Haixiang Sun, Hui Zhu, Xianghong Zhu, Xiaoqiu Tang, Guijun Yan, Jingmei Wang, Donghui Bai, Juan Wang, Liu Wang, Qi Zhou, Huiyan Wang, Chengyan Dai, Lijun Ding, Biyun Xu, Yan Zhou & hellip; Tags: Research Source Type: research

Irf6 directs glandular lineage differentiation of epidermal progenitors and promotes limited sweat gland regeneration in a mouse burn model
Damaged or malfunctioning sweat glands (SGs) after a burn injury would cause significant hyperthermia and even death, and there is an unmet need for effective treatment. Genetically reprogrammed stem cells sho... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 4, 2018 Category: Stem Cells Authors: Bin Yao, Wei Song, Zhao Li, Tian Hu, Rui Wang, Yihui Wang, Sha Huang and Xiaobing Fu Tags: Research Source Type: research

Iberian pig mesenchymal stem/stromal cells from dermal skin, abdominal and subcutaneous adipose tissues, and peripheral blood: in vitro characterization and migratory properties in inflammation
Recently, the capacity of mesenchymal stem/stromal cells (MSCs) to migrate into damaged tissues has been reported. For MSCs to be a promising tool for tissue engineering and cell and gene therapy, it is essent... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 4, 2018 Category: Stem Cells Authors: Alexandra Calle, Clara Barraj ón-Masa, Ernesto Gómez-Fidalgo, Mercedes Martín-Lluch, Paloma Cruz-Vigo, Raúl Sánchez-Sánchez and Miguel Ángel Ramírez Tags: Research Source Type: research

Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice
Diabetes is a proinflammatory state. Fibrosis of the renal glomerulus is the most common cause of end-stage renal disease. Glomerulosclerosis is caused by the accumulation of extracellular matrix (ECM) protein... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 4, 2018 Category: Stem Cells Authors: Ching-Chuan Hsieh, Chun-Liang Lin, Jie-Teng He, Meihua Chiang, Yuhsiu Wang, Yu-Chin Tsai, Chien-Hui Hung and Pey-Jium Chang Tags: Research Source Type: research

DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis
The mammalian target of rapamycin (mTOR) pathway plays a significant role in osteogenic differentiation and bone maintenance. As the only known endogenous inhibitor of mTOR function, DEP domain containing mTOR... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 4, 2018 Category: Stem Cells Authors: Si Chen, Lingfei Jia, Shan Zhang, Yunfei Zheng and Yongsheng Zhou Tags: Research Source Type: research

Long-term expansion of primary equine keratinocytes that maintain the ability to differentiate into stratified epidermis
Skin injuries in horses frequently lead to chronic wounds that lack a keratinocyte cover essential for healing. The limited proliferation of equine keratinocytes using current protocols has limited their use f... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - July 4, 2018 Category: Stem Cells Authors: Faris Alkhilaiwi, Liqing Wang, Dan Zhou, Terje Raudsepp, Sharmila Ghosh, Siddartha Paul, Nancy Palechor-Ceron, Sabine Brandt, Jennifer Luff, Xuefeng Liu, Richard Schlegel and Hang Yuan Tags: Research Source Type: research

Human mesenchymal stem cell-derived extracellular vesicles/estrogen combined therapy safely ameliorates experimentally induced intrauterine adhesions in a female rat model
Mesenchymal stem cells (MSCs) have diverse functions in regulating injury and inflammation through the secretion of extracellular vesicles (EVs). (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 28, 2018 Category: Stem Cells Authors: Nesrine Ebrahim, Ola Mostafa, Rania Ebrahim El Dosoky, Inas A. Ahmed, Ahmed S. Saad, Abeer Mostafa, Dina Sabry, Khalid Abdelaziz Ibrahim and Ayman Samir Farid Tags: Research Source Type: research

Pericellular collagen I coating for enhanced homing and chondrogenic differentiation of mesenchymal stem cells in direct intra-articular injection
Direct intra-articular injection (DIAI) of mesenchymal stem cells (MSCs) is a promising technique for cartilage repair. However, the repair process was hindered by the absence of scaffold and poor cell –matrix ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 27, 2018 Category: Stem Cells Authors: Hansong Xia, Chi Liang, Pan Luo, Junjie Huang, Jinshen He, Zili Wang, Xu Cao, Cheng Peng and Song Wu Tags: Research Source Type: research

Eph/Ephrin-mediated stimulation of human bone marrow mesenchymal stromal cells correlates with changes in cell adherence and increased cell death
Mesenchymal stromal cells (MSC) are components of connective tissues and, in vitro, cell entities characterized by cell adhesion and immunophenotyping, although specific markers for their identification are la... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 26, 2018 Category: Stem Cells Authors: David Alfaro and Agust ín G. Zapata Tags: Research Source Type: research

Early gestational mesenchymal stem cell secretome attenuates experimental bronchopulmonary dysplasia in part via exosome-associated factor TSG-6
Mesenchymal stem cells (MSCs) are promising tools for the treatment of human lung disease and other pathologies relevant to newborn medicine. Recent studies have established MSC exosomes (EXO), as one of the m... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 26, 2018 Category: Stem Cells Authors: Sushma Chaubey, Sam Thueson, Devasena Ponnalagu, Mohammad Afaque Alam, Ciprian P. Gheorghe, Zubair Aghai, Harpreet Singh and Vineet Bhandari Tags: Research Source Type: research

Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor- α-induced senescence
Cell therapy for the treatment of intervertebral disc degeneration (IDD) faces serious barriers since tissue-specific adult cells such as nucleus pulposus cells (NPCs) have limited proliferative ability and po... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 26, 2018 Category: Stem Cells Authors: Xiao-Chuan Li, Mao-Sheng Wang, Wei Liu, Cheng-Fan Zhong, Gui-Bin Deng, Shao-Jian Luo and Chun-Ming Huang Tags: Research Source Type: research

Deer thymosin beta 10 functions as a novel factor for angiogenesis and chondrogenesis during antler growth and regeneration
Deer antlers are the only known mammalian organ with vascularized cartilage that can completely regenerate. Antlers are of real significance as a model of mammalian stem cell-based regeneration with particular... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 19, 2018 Category: Stem Cells Authors: Wei Zhang, Wenhui Chu, Qingxiu Liu, Dawn Coates, Yudong Shang and Chunyi Li Tags: Research Source Type: research

Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium
Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to experimental approaches to augment natural tendon ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 19, 2018 Category: Stem Cells Authors: Mohammad R. Khan, Jayesh Dudhia, Frederic H. David, Roberta De Godoy, Vedika. Mehra, Gillian Hughes, Stephanie G. Dakin, Andrew J. Carr, Allen E. Goodship and Roger K. W. Smith Tags: Research Source Type: research

Inhibition of the RhoGTPase Cdc42 by ML141 enhances hepatocyte differentiation from human adipose-derived mesenchymal stem cells via the Wnt5a/PI3K/miR-122 pathway: impact of the age of the donor
Human adipose-derived mesenchymal stem cells (hADSCs) are promising cells that may promote hepatocyte differentiation (Hep-Dif) and improve liver function, but the involvement of Cdc42, a key small RhoGTPase w... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 19, 2018 Category: Stem Cells Authors: Diana Chaker, Charbel Mouawad, Albert Azar, Didier Quilliot, Ibrahim Achkar, Ziad Fajloun and Nehman Makdissy Tags: Research Source Type: research

Induced pluripotent stem cell-derived mesenchymal stem cells activate quiescent T cells and elevate regulatory T cell response via NF- κB in allergic rhinitis patients
It has been demonstrated previously that induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (MSCs) have immunosuppressive effects on activated T cells. However, the effects of iPSC-MSCs on qui... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 19, 2018 Category: Stem Cells Authors: Xing-Liang Fan, Qing-Xiang Zeng, Xin Li, Cheng-Lin Li, Zhi-Bin Xu, Xue-Quan Deng, Jianbo Shi, Dong Chen, Song Guo Zheng and Qing-Ling Fu Tags: Research Source Type: research

Adipose-derived and bone marrow mesenchymal stem cells: a donor-matched comparison
Adipose-derived stem cells (ASCs) have been introduced as an alternative to bone marrow mesenchymal stem cells (BMSCs) for cell-based therapy. However, different studies comparing ASCs and BMSCs have shown con... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 19, 2018 Category: Stem Cells Authors: Samih Mohamed-Ahmed, Inge Fristad, Stein Atle Lie, Salwa Suliman, Kamal Mustafa, Hallvard Vindenes and Shaza B. Idris Tags: Research Source Type: research

Clonal dynamics studied in cultured induced pluripotent stem cells reveal major growth imbalances within a few weeks
Human induced pluripotent stem (iPS) cells have revolutionised research and spark hopes for future tissue replacement therapies. To obtain high cell numbers, iPS cells can be expanded indefinitely. However, as... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 18, 2018 Category: Stem Cells Authors: David Breni ère-Letuffe, Aya Domke-Shibamiya, Arne Hansen, Thomas Eschenhagen, Boris Fehse, Kristoffer Riecken and Justus Stenzig Tags: Research Source Type: research

A pivotal role of BEX1 in liver progenitor cell expansion in mice
The activation and expansion of bipotent liver progenitor cells (LPCs) are indispensable for liver regeneration after severe or chronic liver injury. However, the underlying molecular mechanisms regulating LPC... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 15, 2018 Category: Stem Cells Authors: Yuting Gu, Weiting Wei, Yiji Cheng, Bing Wan, Xinyuan Ding, Hui Wang, Yanyun Zhang and Min Jin Tags: Research Source Type: research

Optimizing the method for generation of integration-free induced pluripotent stem cells from human peripheral blood
Generation of induced pluripotent stem cells (iPSCs) from human peripheral blood provides a convenient and low-invasive way to obtain patient-specific iPSCs. The episomal vector is one of the best approaches f... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 15, 2018 Category: Stem Cells Authors: Haihui Gu, Xia Huang, Jing Xu, Lili Song, Shuping Liu, Xiao-bing Zhang, Weiping Yuan and Yanxin Li Tags: Short report Source Type: research

Melatonin rescued interleukin 1 β-impaired chondrogenesis of human mesenchymal stem cells
Osteoarthritis (OA) is a widespread arthritic disease and a primary cause of disability. Increasing evidence suggests that inflammation has a pivotal part in its pathogenesis. Interleukin-1 β (IL-1β) is a prima... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 14, 2018 Category: Stem Cells Authors: Bo Gao, Wenjie Gao, Zizhao Wu, Taifeng Zhou, Xianjian Qiu, Xudong Wang, Chengjie Lian, Yan Peng, Anjing Liang, Jincheng Qiu, Yuanxin Zhu, Caixia Xu, Yibing Li, Peiqiang Su and Dongsheng Huang Tags: Research Source Type: research

Co-stimulation of LPAR1 and S1PR1/3 increases the transplantation efficacy of human mesenchymal stem cells in drug-induced and alcoholic liver diseases
One of the major obstacles facing stem cell therapy is the limited number of functional stem cells available after transplantation due to the harsh microenvironment surrounding the damaged tissue. The aim of t... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 14, 2018 Category: Stem Cells Authors: Mianhuan Li, Yi Lv, Feng Chen, Xiaoyan Wang, Jiang Zhu, Hao Li and Jia Xiao Tags: Research Source Type: research

Ex vivo evaluation of intravitreal mesenchymal stromal cell viability using bioluminescence imaging
Bone marrow-derived mesenchymal stromal cell (MSC) therapy is a promising treatment for several degenerative ocular diseases; however, no reproducible method of monitoring these cells into the eye has been est... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 13, 2018 Category: Stem Cells Authors: Carolina Assis P. Vilela, Lucas Eduardo B. Souza, Rubens C. Siqueira, Rodrigo T. Calado, Dimas T. Covas and Jayter S. Paula Tags: Research Source Type: research

Epithelial disruption: a new paradigm enabling human airway stem cell transplantation
Airway disease is a primary cause of morbidity and early mortality for patients with cystic fibrosis (CF). Cell transplantation therapy has proven successful for treating immune disorders and may have the pote... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 13, 2018 Category: Stem Cells Authors: Nigel Farrow, Patricia Cmielewski, Martin Donnelley, Nathan Rout-Pitt, Yuben Moodley, Ivan Bertoncello and David Parsons Tags: Research Source Type: research

Mesenchymal stem cells and porous β-tricalcium phosphate composites prepared through stem cell screen-enrich-combine(−biomaterials) circulating system for the repair of critical size bone defects in goat tibia
Efficacious bone substitute is essential for the treatment of a critical size bone defect. Currently, the bone substitutes commonly used in clinical practice lack osteogenic capacity and the therapeutic effica... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 13, 2018 Category: Stem Cells Authors: Wenxiang Chu, Yaokai Gan, Yifu Zhuang, Xin Wang, Jie Zhao, Tingting Tang and Kerong Dai Tags: Research Source Type: research

Neural stem cell therapy for subacute and chronic ischemic stroke
Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a worldwide leading c... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - June 13, 2018 Category: Stem Cells Authors: Austin C. Boese, Quan-Son Eric Le, Dylan Pham, Milton H. Hamblin and Jean-Pyo Lee Tags: Review Source Type: research