Multipotency of mouse trophoblast stem cells
In a number of disease processes, the body is unable to repair injured tissue, promoting the need to develop strategies for tissue repair and regeneration, including the use of cellular therapeutics. Trophobla... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 13, 2020 Category: Stem Cells Authors: Minmin Hou, Junwen Han, Gu Li, Min-Young Kwon, Jiani Jiang, Sirisha Emani, Elizabeth S. Taglauer, Jin-Ah Park, Eun-Bee Choi, Munender Vodnala, Yick W. Fong, Sitaram M. Emani, Ivan O. Rosas, Mark A. Perrella and Xiaoli Liu Tags: Research Source Type: research

Exosomal miR-135a derived from human amnion mesenchymal stem cells promotes cutaneous wound healing in rats and fibroblast migration by directly inhibiting LATS2 expression
In this study, we found that local injection of human amnion mesenchymal stem cells into wounds in rats cou... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 13, 2020 Category: Stem Cells Authors: Shaoying Gao, Tao Chen, Yi Hao, Feifei Zhang, Xiujun Tang, Dali Wang, Zairong Wei and Jianping Qi Tags: Research Source Type: research

Infusion-related thrombogenesis by liver-derived mesenchymal stem cells controlled by anticoagulant drugs in 11 patients with liver-based metabolic disorders
Mesenchymal stem cell (MSC) transplantation is a fast-developing therapy in regenerative medicine. However, some concerns have been raised regarding their safety and the infusion-related pro-coagulant activity... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 7, 2020 Category: Stem Cells Authors: Louise C. F. Coppin, Fran çoise Smets, Jérome Ambroise, Etienne E. M. Sokal and Xavier Stéphenne Tags: Research Source Type: research

Allo-antibody production after intraarticular administration of mesenchymal stem cells (MSCs) in an equine osteoarthritis model: effect of repeated administration, MSC inflammatory stimulation, and equine leukocyte antigen (ELA) compatibility
Antibody production after allogeneic administration of mesenchymal stem cells (MSCs) could impact their clinical application. Proinflammatory priming of MSCs can potentiate their regulatory ability in vivo but... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 7, 2020 Category: Stem Cells Authors: Laura Barrachina, Alina Cequier, Antonio Romero, Arantza Vitoria, Pilar Zaragoza, Francisco Jos é Vázquez and Clementina Rodellar Tags: Research Source Type: research

Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1G93A mice
The simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (ALS) a fatal and challenging disease. Here, we studied two different cell therapy protocols to protect ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 7, 2020 Category: Stem Cells Authors: Anna Mart ínez-Muriana, Diego Pastor, Renzo Mancuso, Amaya Rando, Rosario Osta, Salvador Martínez, Rubèn López-Vales and Xavier Navarro Tags: Research Source Type: research

Different approaches for transformation of mesenchymal stem cells into hepatocyte-like cells
Due to the prominent role of the liver in the body and detoxification, its functionality can be affected in an irreversible manner by diseases. This phenomenon renders the liver to stop working, leading to mor... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 7, 2020 Category: Stem Cells Authors: Afsoon Afshari, Sara Shamdani, Georges Uzan, Sina Naserian and Negar Azarpira Tags: Review Source Type: research

Efficacy of mesenchymal stem cells in animal models of lupus nephritis: a meta-analysis
Lupus nephritis is usually manifested by proteinuria, active urinary sediment, hypertension, and renal failure and is a serious complication with more than 50% occurrence in systemic lupus erythematosus patien... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 4, 2020 Category: Stem Cells Authors: Tianbiao Zhou, Chunling Liao, Hong-Yan Li, Wenshan Lin, Shujun Lin and Hongzhen Zhong Tags: Research Source Type: research

Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8+CD28 − T cells
This study aims to investiga... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 4, 2020 Category: Stem Cells Authors: Na Yin, Chenting Wu, Jianping Qiu, Yueming Zhang, Le Bo, Ying Xu, Mengdie Shi, Songyue Zhu, Guangzhao Yang and Caiping Mao Tags: Research Source Type: research

Cell-free fat extract promotes tissue regeneration in a tissue expansion model
Tissue expansion techniques play an important role in plastic surgery. How to improve the quality of the expanded skin and shorten the expansion period are still worth investigating. Our previous studies found... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 4, 2020 Category: Stem Cells Authors: Mingwu Deng, Xiangsheng Wang, Ziyou Yu, Yizuo Cai, Wei Liu, Guangdong Zhou, Xiansong Wang, Zheyuan Yu, Wei Li and Wen Jie Zhang Tags: Research Source Type: research

Enhancement of periodontal tissue regeneration by conditioned media from gingiva-derived or periodontal ligament-derived mesenchymal stem cells: a comparative study in rats
Evidence has demonstrated conditioned medium (CM) from periodontal ligament stem cells (PDLSCs) improved periodontal regeneration. Gingival mesenchymal stem cells (GMSCs) have been considered an alternative st... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 3, 2020 Category: Stem Cells Authors: Jiling Qiu, Xiaotong Wang, Haowen Zhou, Chunshu Zhang, Yijia Wang, Jiahui Huang, Meng Liu, Pishan Yang and Aimei Song Tags: Research Source Type: research

Therapeutic evidence of umbilical cord-derived mesenchymal stem cell transplantation for cerebral palsy: a randomized, controlled trial
Cerebral palsy (CP) is a syndrome of childhood movement and posture disorders. Clinical evidence is still limited and sometimes inconclusive about the benefits of human umbilical cord mesenchymal stem cells (h... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 3, 2020 Category: Stem Cells Authors: Jiaowei Gu, Li Huang, Che Zhang, Yong Wang, Ruibo Zhang, Ziliang Tu, Hengdong Wang, Xihui Zhou, Zhousheng Xiao, Zegan Liu, Xiang Hu, Zunchen Ke, Dabin Wang and Li Liu Tags: Research Source Type: research

In vivo monitoring of dynamic interaction between neutrophil and human umbilical cord blood-derived mesenchymal stem cell in mouse liver during sepsis
In this study, we investigated how int... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 3, 2020 Category: Stem Cells Authors: Sung Yong Ahn, Yong-Sun Maeng, Yu Rim Kim, Young Ho Choe, Han Sung Hwang and Young-Min Hyun Tags: Research Source Type: research

AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells
Mesenchymal stromal cell (MSC) stemness capacity diminishes over prolonged in vitro culture, which negatively affects their application in regenerative medicine. To slow down the senescence of MSCs, here, we h... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 3, 2020 Category: Stem Cells Authors: Mohammadhossein Khorraminejad-Shirazi, Mahsa Sani, Tahereh Talaei-Khozani, Mohammadreza Dorvash, Malihe Mirzaei, Mohammad Ali Faghihi, Ahmad Monabati and Armin Attar Tags: Research Source Type: research

Rapid generation of purified human RPE from pluripotent stem cells using 2D cultures and lipoprotein uptake-based sorting
Despite increasing demand, current protocols for human pluripotent stem cell (hPSC)-derived retinal pigment epithelium (RPE) remain time, labor, and cost intensive. Additionally, absence of robust methods for ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 3, 2020 Category: Stem Cells Authors: Fabio Michelet, Aishwarya Balasankar, Nickolas Teo, Lawrence W. Stanton and Shweta Singhal Tags: Research Source Type: research

EphrinB2 overexpression enhances osteogenic differentiation of dental pulp stem cells partially through ephrinB2-mediated reverse signaling
Alveolar bone loss is a frequent occurrence. Dental pulp stem cells (DPSCs) which have invasive accessibility and high osteogenic potential is a promising source for cell-based bone regeneration. EphrinB2 is i... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 29, 2020 Category: Stem Cells Authors: Wen Wang, Changyong Yuan, Tengyu Geng, Yi Liu, Shaoyue Zhu, Chengfei Zhang, Zongxiang Liu and Penglai Wang Tags: Research Source Type: research

TGF- β/SMAD signaling regulation of mesenchymal stem cells in adipocyte commitment
Adipocytes arising from mesenchymal stem cells (MSCs) requires MSC adipocyte commitment and differentiation of preadipocytes to mature adipocytes. Several signaling and some cytokines affect the adipogenesis o... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 29, 2020 Category: Stem Cells Authors: Sheng-Nan Li and Jia-Fa Wu Tags: Review Source Type: research

Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion
This study investigated whether exosomes derived from bone marrow mesenchym... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 28, 2020 Category: Stem Cells Authors: Lu Zhang, Guangjun Jiao, Shanwu Ren, Xiaoqian Zhang, Ci Li, Wenliang Wu, Hongliang Wang, Haichun Liu, Hongming Zhou and Yunzhen Chen Tags: Research Source Type: research

Umbilical cord-matrix stem cells induce the functional restoration of vascular endothelial cells and enhance skin wound healing in diabetic mice via the polarized macrophages
Chronic nonhealing wounds represent one of the most common complications of diabetes and require advanced treatment strategies. Increasing evidence supports the important role of mesenchymal stem cells in diab... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 28, 2020 Category: Stem Cells Authors: Shichang Zhang, Li Chen, Guoying Zhang and Bo Zhang Tags: Research Source Type: research

Correction to: BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt/ β-catenin signaling
The original article [1] contains an error in Fig. 5 whereby sub-Fig. 5c, d& 5e are mistakenly mixed-up. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 23, 2020 Category: Stem Cells Authors: Rui Zuo, Minghan Liu, Yanqiu Wang, Jie Li, Wenkai Wang, Junlong Wu, Chao Sun, Bin Li, Ziwen Wang, Weiren Lan, Chao Zhang, Chunmeng Shi and Yue Zhou Tags: Correction Source Type: research

Scaffold vascularization method using an adipose-derived stem cell (ASC)-seeded scaffold prefabricated with a flow-through pedicle
Vascularization is important for the clinical application of tissue engineered products. Both adipose-derived stem cells (ASCs) and surgical prefabrication can be used to induce angiogenesis in scaffolds. Our ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 23, 2020 Category: Stem Cells Authors: Tomasz D ębski, Agata Kurzyk, Barbara Ostrowska, Juliusz Wysocki, Jakub Jaroszewicz, Wojciech Święszkowski and Zygmunt Pojda Tags: Research Source Type: research

Reduced culture temperature attenuates oxidative stress and inflammatory response facilitating expansion and differentiation of adipose-derived stem cells
Adipose-derived stem cell (ASC) expansion under atmospheric oxygen levels (21%) was previously shown to cause increased reactive oxygen species (ROS) accumulation and genetic instability compared to cells cult... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 23, 2020 Category: Stem Cells Authors: Gal Tirza, Inna Solodeev, Meirav Sela, Ilanit Greenberg, Metsada Pasmanik-Chor, Eyal Gur and Nir Shani Tags: Research Source Type: research

Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN/AKT pathway
A growing body of evidence suggests that stem cell-derived exosomal microRNAs (miRNAs) could be a promising cardioprotective therapy in the context of hypoxic conditions. The present study aims to explore how ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 23, 2020 Category: Stem Cells Authors: Zhuzhi Wen, Zun Mai, Xiaolin Zhu, Tao Wu, Yangxin Chen, Dengfeng Geng and Jingfeng Wang Tags: Research Source Type: research

Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate IL-6-induced acute liver injury through miR-455-3p
Using a toxin-induced nonhuman primate model of acute liver failure (ALF), we previously reported that peripheral infusion of human umbilical cord mesenchymal stem cells (hUC-MSCs) strongly suppresses the acti... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 23, 2020 Category: Stem Cells Authors: Mingyang Shao, Qing Xu, Zhenru Wu, Yuwei Chen, Yuke Shu, Xiaoyue Cao, Menglin Chen, Bo Zhang, Yongjie Zhou, Rong Yao, Yujun Shi and Hong Bu Tags: Research Source Type: research

MicroRNA-126 protects against vascular injury by promoting homing and maintaining stemness of late outgrowth endothelial progenitor cells
Endothelial progenitor cells (EPCs) contribute to reendothelialization and neovascularization and protect against vascular injury and ischemia of various organs. We have previously shown downregulation of micr... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 21, 2020 Category: Stem Cells Authors: Chong Zhe Pei, Bo Liu, Ye Ting Li, Lu Fang, Yi Zhang, Yi Gang Li and Shu Meng Tags: Research Source Type: research

Can supernatant from immortalized adipose tissue MSC replace cell therapy? An in vitro study in chronic wounds model
Mesenchymal stem cells (MSCs) secrete a cocktail of growth factors and cytokines, which could promote tissue regeneration and wound healing. Therefore, in clinical practice, post-culture MSC supernatant treatm... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 21, 2020 Category: Stem Cells Authors: Honorata Kraskiewicz, Maria Paprocka, Aleksandra Bielawska-Pohl, Agnieszka Krawczenko, Kinga Panek, Judyta Kaczy ńska, Agnieszka Szyposzyńska, Mateusz Psurski, Piotr Kuropka and Aleksandra Klimczak Tags: Research Source Type: research

HMOX1 is partly responsible for phenotypic and functional abnormalities in mesenchymal stem cells/stromal cells from placenta of preeclampsia (PE) patients
Preeclampsia is a common obstetric syndrome affecting women in their first pregnancy and characterized by hypertension and proteinuria, which appears after 20  weeks of gestation. It is characterized by high bl... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 21, 2020 Category: Stem Cells Authors: Yasser S. Basmaeil, Dana Algudiri, Reem Alenzi, Abdullah Al Subayyil, Ayodele Alaiya and Tanvir Khatlani Tags: Research Source Type: research

LncRNA-NEAT1 from the competing endogenous RNA network promotes cardioprotective efficacy of mesenchymal stem cell-derived exosomes induced by macrophage migration inhibitory factor via the miR-142-3p/FOXO1 signaling pathway
Extracellular vesicles, especially exosomes, have emerged as key mediators of intercellular communication with the potential to improve cardiac function as part of cell-based therapies. We previously demonstra... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 21, 2020 Category: Stem Cells Authors: Hanbin Chen, Wenzheng Xia and Meng Hou Tags: Research Source Type: research

Systemic conditioned medium treatment from interleukin-1 primed mesenchymal stem cells promotes recovery after stroke
Mesenchymal stem cells (MSCs) hold great potential as a therapy for stroke and have previously been shown to promote recovery in preclinical models of cerebral ischaemia. MSCs secrete a wide range of growth fa... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 21, 2020 Category: Stem Cells Authors: Catriona J. Cunningham, Raymond Wong, Jack Barrington, Sabrina Tamburrano, Emmanuel Pinteaux and Stuart M. Allan Tags: Research Source Type: research

Mesenchymal stem cells promote human melanocytes proliferation and resistance to apoptosis through PTEN pathway in vitiligo
Vitiligo is an acquired chronic and recurrent skin disease that causes a depigmentation disorder, resulting in selective destruction of melanocytes (MC). However, the mechanism that leads to melanocyte dysfunc... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 15, 2020 Category: Stem Cells Authors: Lifei Zhu, Xi Lin, Lin Zhi, Yushan Fang, Keming Lin, Kai Li and Liangcai Wu Tags: Research Source Type: research

Mesenchymal stem cells alleviate liver injury induced by chronic-binge ethanol feeding in mice via release of TSG6 and suppression of STAT3 activation
Mesenchymal stem cells (MSCs) are a population of pluripotent cells that might be used for treatment of liver disease. However, the efficacy of MSCs for mice with alcoholic hepatitis (AH) and its underlying me... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 13, 2020 Category: Stem Cells Authors: Yue-Meng Wan, Zhi-qiang Li, Qiong Zhou, Chang Liu, Men-Jie Wang, Hui-Xin Wu, Yun-Zhen Mu, Yue-Feng He, Yuan Zhang, Xi-Nan Wu, Yu-Hua Li, Zhi-Yuan Xu, Hua-Mei Wu, Ying Xu, Jin-Hui Yang and Xiao-Fang Wang Tags: Research Source Type: research

Management of retinitis pigmentosa by Wharton ’s jelly derived mesenchymal stem cells: preliminary clinical results
The aim of this study is to determine if umbilical cord Wharton ’s jelly derived mesenchymal stem cells implanted in sub-tenon space have beneficial effects on visual functions in retinitis pigmentosa patients ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 13, 2020 Category: Stem Cells Authors: Emin ÖZMERT and Umut ARSLAN Tags: Research Source Type: research

hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice
Accumulating evidence shows that mesenchymal stem cells (MSCs) have the potential as a cellular therapy avenue for schistosome-induced liver injury. Extracellular vesicles (EVs) are membranous vesicles release... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 9, 2020 Category: Stem Cells Authors: Liyang Dong, Yanan Pu, Xiaojun Chen, Xin Qi, Lina Zhang, Lei Xu, Wei Li, Yongbin Ma, Sha Zhou, Jifeng Zhu, Yalin Li, Xuefeng Wang and Chuan Su Tags: Research Source Type: research

IGF-1 enhances BMSC viability, migration, and anti-apoptosis in myocardial infarction via secreted frizzled-related protein 2 pathway
Bone marrow mesenchymal stem cell (BMSC) transplantation represents a promising therapeutic strategy for ischemic heart disease. However, its effects are hampered by the poor viability of transplanted cells an... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 9, 2020 Category: Stem Cells Authors: Mingzhuo Lin, Xinyue Liu, Haoxiao Zheng, Xiaohui Huang, Yu Wu, Anqing Huang, Hailan Zhu, Yunzhao Hu, Weiyi Mai and Yuli Huang Tags: Research Source Type: research

Mircrining the injured heart with stem cell-derived exosomes: an emerging strategy of cell-free therapy
Bone marrow-derived mesenchymal stem cells (MSCs) have successfully progressed to phase III clinical trials successive to an intensive in vitro and pre-clinical assessment in experimental animal models of isch... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 9, 2020 Category: Stem Cells Authors: Khawaja Husnain Haider and Beatrice Aramini Tags: Review Source Type: research

Neurovascular effects of umbilical cord blood-derived stem cells in growth-restricted newborn lambs
Neonatal ventilation exacerbates brain injury in lambs with fetal growth restriction (FGR), characterized by neuroinflammation and reduced blood-brain barrier integrity, which is normally maintained by the neu... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 8, 2020 Category: Stem Cells Authors: Atul Malhotra, Margie Castillo-Melendez, Beth J. Allison, Amy E. Sutherland, Ilias Nitsos, Yen Pham, Courtney A. McDonald, Michael C. Fahey, Graeme R. Polglase, Graham Jenkin and Suzanne L. Miller Tags: Research Source Type: research

Metformin alleviates muscle wasting post-thermal injury by increasing Pax7-positive muscle progenitor cells
Profound skeletal muscle wasting and weakness is common after severe burn and persists for years after injury contributing to morbidity and mortality of burn patients. Currently, no ideal treatment exists to i... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 8, 2020 Category: Stem Cells Authors: Yusef Yousuf, Andrea Datu, Ben Barnes, Saeid Amini-Nik and Marc G. Jeschke Tags: Research Source Type: research

Stem cell-derived cell sheet transplantation for heart tissue repair in myocardial infarction
Stem cell-derived sheet engineering has been developed as the next-generation treatment for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem cell transplantation and s... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 8, 2020 Category: Stem Cells Authors: Rui Guo, Masatoshi Morimatsu, Tian Feng, Feng Lan, Dehua Chang, Feng Wan and Yunpeng Ling Tags: Review Source Type: research

Establishment of long-term serum-free culture for lacrimal gland stem cells aiming at lacrimal gland repair
Aqueous-deficient dry eye disease (ADDED) resulting from dysfunction of the lacrimal gland (LG) is currently incurable. Although LG stem/progenitor cell-based therapy is considered to be a promising strategy f... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 8, 2020 Category: Stem Cells Authors: Sa Xiao and Yan Zhang Tags: Research Source Type: research

Epigenetic regulation of IFITM1 expression in lipopolysaccharide-stimulated human mesenchymal stromal cells
Toll-like receptor 4 (TLR4) ligands such as lipopolysaccharide (LPS) activate immunomodulatory functions and the migration of human mesenchymal stromal cells (hMSCs). Here, we study the migration-related gene ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 7, 2020 Category: Stem Cells Authors: Sun Hwa Kim, Hae In Choi, Mi Ran Choi, Ga Yeong An, Bert Binas, Kyoung Hwa Jung and Young Gyu Chai Tags: Research Source Type: research

Endometrial stromal cells exhibit a distinct phenotypic and immunomodulatory profile
In Asherman ’s syndrome (AS), intrauterine scarring and fibrotic adhesions lead to menstrual disorders, pregnancy loss, or infertility. A few clinical trials have piloted cell therapy to overcome AS. Understand... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 6, 2020 Category: Stem Cells Authors: Suzanna Queckb örner, Elisabeth Syk Lundberg, Kristina Gemzell-Danielsson and Lindsay C. Davies Tags: Research Source Type: research

Effect of hCMSCs and liraglutide combination in ALI through cAMP/PKAc/ β-catenin signaling pathway
ALI/ARDS is the major cause of acute respiratory failure in critically ill patients. As human chorionic villi-derived MSCs (hCMSCs) could attenuate ALI in the airway injury model, and liraglutide, glucagon-lik... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 3, 2020 Category: Stem Cells Authors: Yun Feng, Linlin Wang, Xiaoying Ma, Xiaotong Yang, Ocholi Don, Xiaoyan Chen, Jieming Qu and Yuanlin Song Tags: Research Source Type: research

Long non-coding RNA FER1L4 promotes osteogenic differentiation of human periodontal ligament stromal cells via miR-874-3p and vascular endothelial growth factor A
Periodontal ligament stromal cells (PDLSCs) are ideal cell sources for periodontal tissue repair and regeneration, but little is known about what determines their osteogenic capacity. Long non-coding RNAs (lnc... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 3, 2020 Category: Stem Cells Authors: Yiping Huang, Yineng Han, Runzhi Guo, Hao Liu, Xiaobei Li, Lingfei Jia, Yunfei Zheng and Weiran Li Tags: Research Source Type: research

Reproducibility of GMP-compliant production of therapeutic stressed peripheral blood mononuclear cell-derived secretomes, a novel class of biological medicinal products
The recent concept of secretome-based tissue regeneration has profoundly altered the field of regenerative medicine and offers promising novel therapeutic options. In contrast to medicinal products with a sing... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 3, 2020 Category: Stem Cells Authors: Maria Laggner, Alfred Gugerell, Christiane Bachmann, Helmut Hofbauer, Vera Vorstandlechner, Marcus Seibold, Ghazaleh Gouya Lechner, Anja Peterbauer, Sibylle Madlener, Svitlana Demyanets, Dirk Sorgenfrey, Tobias Ostler, Michael Erb, Michael Mildner and Hen Tags: Research Source Type: research

Aerobic and resistance training enhances endothelial progenitor cell function via upregulation of caveolin-1 in mice with type 2 diabetes
To explore the effect of aerobic training (AT), resistance training (RT) or a combination of AT and RT (AT+RT) on the function of endothelial progenitor cells (EPCs) in mice with type 2 diabetes and the potent... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 3, 2020 Category: Stem Cells Authors: Lu Zhai, Yuhua Liu, Wenpiao Zhao, Qingyun Chen, Tao Guo, Wei Wei, Zhuchun Luo, Yanfeng Huang, Cui Ma, Feng Huang and Xia Dai Tags: Research Source Type: research

Cellular therapy of corneal epithelial defect by adipose mesenchymal stem cell-derived epithelial progenitors
This study investigated CE reformation usin... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 3, 2020 Category: Stem Cells Authors: Francisco Bandeira, Tze-Wei Goh, Melina Setiawan, Gary Hin-Fai Yam and Jodhbir S. Mehta Tags: Research Source Type: research

Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy
Myopathy and exercise intolerance are prominent clinical features in carriers of a point-mutation or large-scale deletion in the mitochondrial DNA (mtDNA). In the majority of patients, the mtDNA mutation is he... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 21, 2019 Category: Stem Cells Authors: Florence van Tienen, Ruby Zelissen, Erika Timmer, Marike van Gisbergen, Patrick Lindsey, Mattia Quattrocelli, Maurilio Sampaolesi, Elvira Mulder-den Hartog, Irenaeus de Coo and Hubert Smeets Tags: Research Source Type: research

Menstrual blood-derived stem cells: toward therapeutic mechanisms, novel strategies, and future perspectives in the treatment of diseases
Menstrual blood-derived stem cells (MenSCs) have great potential in the treatment of various diseases. As a novel type of mesenchymal stem cells (MSCs), MenSCs have attracted more interest due to their therape... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 21, 2019 Category: Stem Cells Authors: Lijun Chen, Jingjing Qu, Tianli Cheng, Xin Chen and Charlie Xiang Tags: Review Source Type: research

Electromagnetic field treatment increases purinergic receptor P2X7 expression and activates its downstream Akt/GSK3 β/β-catenin axis in mesenchymal stem cells under osteogenic induction
Imbalance in bone formation and resorption is a crucial component of the pathological process leading to osteoporosis. Electromagnetic fields (EMFs) have been reported to be beneficial to osteogenesis, althoug... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 21, 2019 Category: Stem Cells Authors: Yingchi Zhang, Wenkai Li, Chaoxu Liu, Jiyuan Yan, Xuefeng Yuan, Wei Wang, Huaixi Wang, Hua Wu and Yong Yang Tags: Research Source Type: research

Melatonin promotes the BMP9-induced osteogenic differentiation of mesenchymal stem cells by activating the AMPK/ β-catenin signalling pathway
Mesenchymal stem cells (MSCs) play a crucial role in maintaining the dynamic balance of bone metabolism. Melatonin may have a regulatory effect on bone metabolism by regulating the lineage commitment and diffe... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 21, 2019 Category: Stem Cells Authors: Tianyuan Jiang, Chao Xia, Xiaoting Chen, Yan Hu, Yan Wang, Jin Wu, Shuyan Chen and Yanhong Gao Tags: Research Source Type: research

Correction to: miR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac c-kit+ cells to promote proliferation and inhibit apoptosis through a negative feedback loop
After publication of our article [1] we became aware that there were errors in Fig. 5b and Fig. 6c, namely that the immunofluorescence of EDU-positive cells of the CABLES1 transfection group in Fig. 5b (panel ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 20, 2019 Category: Stem Cells Authors: Jingjin Liu, Yongshun Wang, Jinjin Cui, Meng Sun, Zhongyue Pu, Chao Wang, Wenjuan Du, Xinxin Liu, Jian Wu, Jingbo Hou, Shuo Zhang and Bo Yu Tags: Correction Source Type: research