Ultrasound enhances the therapeutic potential of mesenchymal stem cells wrapped in greater omentum for aristolochic acid nephropathy
Mesenchymal stem cells (MSCs) have been reported to promote regeneration in both subjects with acute kidney injury (AKI) and chronic kidney disease (CKD), but their efficacy remains limited, probably because m... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - May 3, 2021 Category: Stem Cells Authors: Yuanjun Yang, Xiaodong Geng, Kun Chi, Chao Liu, Ran Liu, Xiangmei Chen, Quan Hong and Guangyan Cai Tags: Research Source Type: research

TRPC7 regulates the electrophysiological functions of embryonic stem cell-derived cardiomyocytes
Biological pacemakers consisting of pluripotent stem cell-derived cardiomyocytes are potentially useful for treating bradycardia. However, tachyarrhythmia caused by derived cardiomyocytes themselves is one of ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - May 3, 2021 Category: Stem Cells Authors: Xianji Liu, Rui Zhao, Qianqian Ding, Xiaoqiang Yao and Suk Ying Tsang Tags: Research Source Type: research

Small extracellular vesicles from human adipose-derived mesenchymal stromal cells: a potential promoter of fat graft survival
In this study, our purpose is to explore the characteristics of the small ex... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - May 3, 2021 Category: Stem Cells Authors: Aizhen Chen, Shijie Tang, Jiawei He, Xiangyu Li, Guohao Peng, Haoruo Zhang, Jinghua Chen, Liangwan Chen and Xiaosong Chen Tags: Research Source Type: research

Upregulating CXCR7 accelerates endothelial progenitor cell-mediated endothelial repair by activating Akt/Keap-1/Nrf2 signaling in diabetes mellitus
Endothelial progenitor cell (EPC) dysfunction contributes to vascular disease in diabetes mellitus. However, the molecular mechanism underlying EPC dysfunction and its contribution to delayed reendothelializat... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - May 3, 2021 Category: Stem Cells Authors: Chunyu Jiang, Ruiting Li, Chaoyang Xiu, Xu Ma, Hui Hu, Liming Wei, Yihan Tang, Mingyang Tao and Jungong Zhao Tags: Research Source Type: research

Combined topical and systemic administration with human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes markedly promoted cutaneous wound healing and regeneration
Cutaneous wound healing and regeneration have become a recognized health challenge in the world, which causes severe damage to the mental and physical health of patients. Human adipose-derived mesenchymal stem... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - May 1, 2021 Category: Stem Cells Authors: Yang Zhou, Bo Zhao, Xin-Liao Zhang, Yi-jun Lu, Shou-Tao Lu, Jian Cheng, Yu Fu, Lin Lin, Ning-Yan Zhang, Pei-Xin Li, Jing Zhang and Jun Zhang Tags: Research Source Type: research

Consecutive daily administration of intratracheal surfactant and human umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced lung injury in neonatal rats
Surfactant therapy is a standard of care for preterm infants with respiratory distress and reduces the incidence of death and bronchopulmonary dysplasia in these patients. Our previous study found that mesench... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - May 1, 2021 Category: Stem Cells Authors: Hsiu-Chu Chou, Chien-Hsiang Chang, Chien-Han Chen, Willie Lin and Chung-Ming Chen Tags: Research Source Type: research

Clinical outcomes of modified simple limbal epithelial transplantation for limbal stem cell deficiency in Chinese population: a retrospective case series
To report the clinical outcomes of a novel surgical technique, namely simple limbal epithelial transplantation (SLET), for the treatment of limbal stem cell deficiency (LSCD). (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - May 1, 2021 Category: Stem Cells Authors: Yinghui Wang, Xiaodan Hu, Ke Yang, Yang Zhang, Shijing Deng, Zhiqun Wang, Shang Li, Lei Tian and Ying Jie Tags: Research Source Type: research

Clinical-grade human dental pulp stem cells suppressed the activation of osteoarthritic macrophages and attenuated cartilaginous damage in a rabbit osteoarthritis model
Although increasing evidence has demonstrated that human dental pulp stem cells (hDPSCs) are efficacious for the clinical treatment of skeletal disorders, the underlying mechanisms remain incompletely understo... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - May 1, 2021 Category: Stem Cells Authors: Pei-Lin Li, Yu-Xing Wang, Zhi-Dong Zhao, Zhi-Ling Li, Jia-Wu Liang, Qian Wang, Bo-Feng Yin, Rui-Cong Hao, Meng-Yue Han, Li Ding, Chu-Tse Wu and Heng Zhu Tags: Research Source Type: research

Correction to: Skin regeneration is accelerated by a lower dose of multipotent mesenchymal stromal/ stem cells —a paradigm change
(Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 30, 2021 Category: Stem Cells Authors: Gertraud Eylert, Reinhard Dolp, Alexandra Parousis, Richard Cheng, Christopher Auger, Magdalena Holter, Ingrid Lang-Olip, Viola Reiner, Lars-Peter Kamolz and Marc G. Jeschke Tags: Correction Source Type: research

Human acellular amniotic membrane incorporating exosomes from adipose-derived mesenchymal stem cells promotes diabetic wound healing
Diabetic wounds threaten the health and quality of life of patients and their treatment remains challenging. ADSC-derived exosomes have shown encouraging results in enhancing diabetic wound healing. However, h... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 29, 2021 Category: Stem Cells Authors: Shune Xiao, Chunfang Xiao, Yong Miao, Jin Wang, Ruosi Chen, Zhexiang Fan and Zhiqi Hu Tags: Research Source Type: research

Different phenotypes and chondrogenic responses of human menstrual blood and bone marrow mesenchymal stem cells to activin A and TGF- β3
Due to its low capacity for self-repair, articular cartilage is highly susceptible to damage and deterioration, which leads to the development of degenerative joint diseases such as osteoarthritis (OA). Menstr... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 29, 2021 Category: Stem Cells Authors: Ilona Uzieliene, Edvardas Bagdonas, Kazuto Hoshi, Tomoaki Sakamoto, Atsuhiko Hikita, Zivile Tachtamisevaite, Greta Rakauskiene, Giedrius Kvederas, Ali Mobasheri and Eiva Bernotiene Tags: Research Source Type: research

Curcumin-primed human BMSC-derived extracellular vesicles reverse IL-1 β-induced catabolic responses of OA chondrocytes by upregulating miR-126-3p
Curcumin has anti-inflammatory effects and qualifies as a potential candidate for the treatment of osteoarthritis (OA). However, curcumin has limited bioavailability. Extracellular vesicles (EVs) are released ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 29, 2021 Category: Stem Cells Authors: Shushan Li, Sabine St öckl, Christoph Lukas, Marietta Herrmann, Christoph Brochhausen, Matthias A. König, Brian Johnstone and Susanne Grässel Tags: Research Source Type: research

Towards physiologically relevant human pluripotent stem cell (hPSC) models of Parkinson ’s disease
The derivation of human embryonic stem cells followed by the discovery of induced pluripotent stem cells and leaps in genome editing approaches have continuously fueled enthusiasm for the development of new mo... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 29, 2021 Category: Stem Cells Authors: Elena Coccia and Tim Ahfeldt Tags: Review Source Type: research

Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process
Stem cells that have undergone long-term ex vivo expansion are most likely functionally compromised (namely cellular senescence) in terms of their stem cell properties and therapeutic potential. Due to its abi... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 29, 2021 Category: Stem Cells Authors: Yi-Zhou Tan, Xin-Yue Xu, Ji-Min Dai, Yuan Yin, Xiao-Tao He, Yi-Lin Zhang, Tian-Xiao Zhu, Ying An, Bei-Min Tian and Fa-Ming Chen Tags: Research Source Type: research

Correction to: Treating primary immunodeficiencies with defects in NK cells: from stem cell therapy to gene editing
An amendment to this paper has been published and can be accessed via the original article. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 27, 2021 Category: Stem Cells Authors: C. Eguizabal, L. Herrera, M. Ingl és-Ferrándiz and J. C. Izpisua Belmonte Tags: Correction Source Type: research

Establishment of functional epithelial organoids from human lacrimal glands
Tear deficiency due to lacrimal gland (LG) dysfunction is one of the major causes of dry eye disease (DED). Therefore, LG stem cell-based therapies have been extensively reported to regenerate injured lacrimal... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 21, 2021 Category: Stem Cells Authors: Sang Yun Jeong, Woo Hee Choi, Seong Gyeong Jeon, Sookon Lee, Jong-Moon Park, Mira Park, Hookeun Lee, Helen Lew and Jongman Yoo Tags: Research Source Type: research

Efficient differentiation of human embryonic stem cells to retinal pigment epithelium under defined conditions
Age-related macular degeneration (AMD) is a highly prevalent form of blindness caused by loss death of cells of the retinal pigment epithelium (RPE). Transplantation of pluripotent stem cell (PSC)-derived RPE ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 21, 2021 Category: Stem Cells Authors: Ioannis J. Limnios, Yu-Qian Chau, Stuart J. Skabo, Denver C. Surrao and Helen C. O ’Neill Tags: Research Source Type: research

Efficacy and safety of mesenchymal stem cells co-infusion in allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is life-saving for severe hematological conditions. However, its outcomes need further improvement, and co-infusion of mesenchymal stem cells (MSC... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 20, 2021 Category: Stem Cells Authors: Teng Li, Chengxin Luo, Jiasi Zhang, Ling Wei, Wei Sun, Qin Xie, Yan Liu, Yongli Zhao, Shuangnian Xu and Lihua Wang Tags: Research Source Type: research

A novel MSC-based immune induction strategy for ABO-incompatible liver transplantation: a phase I/II randomized, open-label, controlled trial
ABO-incompatible liver transplantation (ABO-i LT) has become a rescue therapeutic option for patients with severe hepatic failure. Although the use of rituximab greatly reduces the morbidity of antibody-mediat... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 16, 2021 Category: Stem Cells Authors: Yingcai Zhang, Jiebin Zhang, Huimin Yi, Jun Zheng, Jianye Cai, Wenjie Chen, Tongyu Lu, Liang Chen, Cong Du, Jianrong Liu, Jia Yao, Hui Zhao, Guoying Wang, Binsheng Fu, Tong Zhang, Jian Zhang & hellip; Tags: Research Source Type: research

Signaling pathways governing breast cancer stem cells behavior
Breast cancer is the second common cancer and the leading cause of malignancy among females overall. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that play a critical role in ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 16, 2021 Category: Stem Cells Authors: Kai Song and Maryam Farzaneh Tags: Review Source Type: research

A randomized, controlled clinical trial of autologous stromal vascular fraction cells transplantation to promote mechanical stretch-induced skin regeneration
The regeneration response of the skin to mechanical stretching in vivo has been explored in reconstructive surgery to repair large-scale deformities. The ability of the skin to regenerate limits the reconstruc... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 15, 2021 Category: Stem Cells Authors: Poh-Ching Tan, Pei-Chuan Chao, Chen Cheng, Chu-Hsin Chen, Ru-Lin Huang, Shuang-Bai Zhou, Yun Xie and Qing-Feng Li Tags: Research Source Type: research

Retraction Note: Exosomes from glioma cells induce a tumor-like phenotype in mesenchymal stem cells by activating glycolysis
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13287-019-1149-5. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 14, 2021 Category: Stem Cells Authors: Zhanjun Ma, Xue Cui, Li Lu, Guohu Chen, Yang Yang, Yan Hu, Yubao Lu, Zhangqi Cao, Yan Wang and Xuexi Wang Tags: Retraction Note Source Type: research

The preconditioning of lithium promotes mesenchymal stem cell-based therapy for the degenerated intervertebral disc via upregulating cellular ROS
Adipose-derived stem cell (ADSC) is one of the most widely used candidate cell for intervertebral disc (IVD) degeneration-related disease. However, the poor survival and low differentiation efficacy in stresse... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 14, 2021 Category: Stem Cells Authors: Zemin Zhu, Hongyuan Xing, Ruofu Tang, Shengjun Qian, Shaoqi He, Qiang Hu and Ning Zhang Tags: Research Source Type: research

Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis
Atherosclerotic renal artery stenosis (ARAS) is a risk factor for ischemic and hypertensive kidney disease (HKD) for which autologous mesenchymal stem cell (MSC) appears to be a promising therapy. However, MSC... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 14, 2021 Category: Stem Cells Authors: Busra Isik, Roman Thaler, Busra B. Goksu, Sabena M. Conley, Hayder Al-Khafaji, Arjunmohan Mohan, Mohsen Afarideh, Abdelrhman M. Abumoawad, Xiang Y. Zhu, James D. Krier, Ishran M. Saadiq, Hui Tang, Alfonso Eirin, LaTonya J. Hickson, Andre J. van Wijnen, St Tags: Research Source Type: research

Andrographolide promotes proliferative and osteogenic potentials of human placenta-derived mesenchymal stem cells through the activation of Wnt/ β-catenin signaling
The in vitro expansion and differentiation of mesenchymal stem cells derived from bone marrow (BM-hMSCs) are considered as potential therapeutic tools for clinical applications in bone tissue engineering and r... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 14, 2021 Category: Stem Cells Authors: Naruphong Phunikom, Nittaya Boonmuen, Pakpoom Kheolamai, Kanoknetr Suksen, Sirikul Manochantr, Chairat Tantrawatpan and Duangrat Tantikanlayaporn Tags: Research Source Type: research

Classical isoforms of protein kinase C (PKC) and Akt regulate the osteogenic differentiation of human dental follicle cells via both β-catenin and NF-κB
Human dental follicle cells (DFCs) are the precursor cells of the periodontium with a high potential for regenerative therapies of (alveolar) bone. However, the molecular mechanisms of osteogenic differentiati... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 14, 2021 Category: Stem Cells Authors: Oliver Pieles, Torsten E. Reichert and Christian Morsczeck Tags: Research Source Type: research

Evaluation of the Spanish population coverage of a prospective HLA haplobank of induced pluripotent stem cells
iPSC (induced pluripotent stem cells) banks of iPSC lines with homozygous HLA (human leukocyte antigen) haplotypes (haplobanks) are proposed as an affordable and off-the-shelf approach to allogeneic transplant... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 13, 2021 Category: Stem Cells Authors: Bel én Álvarez-Palomo, Iris García-Martinez, Jorge Gayoso, Angel Raya, Anna Veiga, María Luisa Abad, Adolfo Eiras, María Guzmán-Fulgencio, Mar Luis-Hidalgo, Cristina Eguizabal, Silvia Santos, Antonio Balas, Raquel Alenda, Francisco Sanchez-Gordo, La Tags: Research Source Type: research

Sinusoidal electromagnetic fields accelerate bone regeneration by boosting the multifunctionality of bone marrow mesenchymal stem cells
The repair of critical-sized bone defects is always a challenging problem. Electromagnetic fields (EMFs), used as a physiotherapy for bone defects, have been suspected to cause potential hazards to human healt... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 13, 2021 Category: Stem Cells Authors: Weigang Li, Wenbin Liu, Wei Wang, Jiachen Wang, Tian Ma, Jingyuan Chen, Hua Wu and Chaoxu Liu Tags: Research Source Type: research

Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6 –HMGB1 deacetylation
Vascular calcification associated with chronic kidney disease (CKD) can increase the risk of mortality. Elevated serum levels of high mobility group box 1 (HMGB1) promotes vascular calcification in CKD via the... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 13, 2021 Category: Stem Cells Authors: Wenqian Wei, Xiaodong Guo, Lijie Gu, Jieshuang Jia, Man Yang, Weijie Yuan and Shu Rong Tags: Research Source Type: research

Identification of circulating CD31+CD45+ cell populations with the potential to differentiate into erythroid cells
Erythro-myeloid progenitors (EMP) are found in a population of cells expressing CD31 and CD45 markers (CD31+CD45+). A recent study indicated that EMPs persist until adulthood and can be a source of endothelial ce... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 13, 2021 Category: Stem Cells Authors: Maria Chiara G. Monaco, Dragan Maric, Ombretta Salvucci, Cristina Antonetti Lamorgese Passeri, Patrizia Accorsi, Eugene O. Major and Anna Concetta Berardi Tags: Letter Source Type: research

Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9+ cells to prevent the development of liver cancer in a mouse model
Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-renewal. The rate of symmetric division increases as more cancer stem cells (CSCs) become malignant; however, the signa... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 12, 2021 Category: Stem Cells Authors: Mi Chen, Chenxia Lu, Hanwen Lu, Junyi Zhang, Dan Qin, Shenghui Liu, Xiaodong Li and Lisheng Zhang Tags: Research Source Type: research

GSK3 β rephosphorylation rescues ALPL deficiency-induced impairment of odontoblastic differentiation of DPSCs
Premature exfoliation of the deciduous teeth is a common manifestation in childhood patients with hypophosphatasia (HPP), which is an autosomal inherited disease caused by ALPL mutations. Dysplasia of the ceme... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2021 Category: Stem Cells Authors: Liqiang Zhang, Jiangdong Zhao, Jiayi Dong, Yuting Liu, Kun Xuan and Wenjia Liu Tags: Research Source Type: research

Adipose-derived stem cells combined with platelet-rich plasma enhance wound healing in a rat model of full-thickness skin defects
This study hypothesizes that the combination ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2021 Category: Stem Cells Authors: Xuejun Ni, Xiuying Shan, Lili Xu, Wenjun Yu, Mingliang Zhang, Chen Lei, Nating Xu, Junyu Lin and Biao Wang Tags: Research Source Type: research

Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice
Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following lo... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2021 Category: Stem Cells Authors: Oliver Treacy, Kevin Lynch, Nick Murphy, Xizhe Chen, Ellen Donohoe, Aoife Canning, Paul Lohan, Georgina Shaw, Gerry Fahy, Aideen E. Ryan and Thomas Ritter Tags: Short report Source Type: research

Secretomes of human pluripotent stem cell-derived smooth muscle cell progenitors upregulate extracellular matrix metabolism in the lower urinary tract and vagina
Adult mesenchymal stem cells (MSCs) have been studied extensively for regenerative medicine; however, they have limited proliferation in vitro, and the long culture time induces cell senescence. MSCs also cont... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2021 Category: Stem Cells Authors: Guobing Zhuang, Yan Wen, Mason Briggs, Qingchun Shao, Darlene Tran, Hongbo Wang and Bertha Chen Tags: Research Source Type: research

Mesenchymal stromal/stem cells and their exosomes for restoration of spermatogenesis in non-obstructive azoospermia: a systemic review
Stem cells have been introduced as new promising therapeutic agents in treatment of degenerative diseases because of having high differentiation potential while maintaining the ability to self-replicate and re... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2021 Category: Stem Cells Authors: Rano Zhankina, Neda Baghban, Manarbek Askarov, Dana Saipiyeva, Almaz Ibragimov, Bakhyt Kadirova, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Ulanbek Zhanbyrbekuly and Amin Tamadon Tags: Review Source Type: research

Sodium alginate-bioglass-encapsulated hAECs restore ovarian function in premature ovarian failure by stimulating angiogenic factor secretion
Human amniotic epithelial cells (hAECs) exhibit a strong capability to restore ovarian function in chemotherapy-induced premature ovarian failure (POF). However, the therapeutic efficacy of hAECs is usually af... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 1, 2021 Category: Stem Cells Authors: Yating Huang, Zhijie Ma, Xiaojun Kuang, Qiuwan Zhang, Haiyan Li and Dongmei Lai Tags: Research Source Type: research

Mesenchymal stem cells and extracellular vesicles in therapy against kidney diseases
Kidney diseases pose a threat to human health due to their rising incidence and fatality rate. In preclinical and clinical studies, it has been acknowledged that mesenchymal stem cells (MSCs) are effective and... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 31, 2021 Category: Stem Cells Authors: Yuling Huang and Lina Yang Tags: Review Source Type: research

Efficacy of topical and systemic transplantation of mesenchymal stem cells in a rat model of diabetic ischemic wounds
Mesenchymal stem cells (MSCs) exert positive effects in chronic wounds. However, critical parameters, such as the most effective administration routes, remain unclear. Accordingly, the purpose of this study wa... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 31, 2021 Category: Stem Cells Authors: Jianxin Yan, Jiaji Liang, Yingxuan Cao, Mariya M. El Akkawi, Xuan Liao, Xiaojia Chen, Chengzhi Li, Kecheng Li, Guanghui Xie and Hongwei Liu Tags: Research Source Type: research

Exosomes derived from human adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis by miR-192-5p/IL-17RA/Smad axis
Hypertrophic scar (HS) is a fibro-proliferative disorder of dermis after burn or trauma and usually leads to esthetic disfiguration and functionary impairment for patients. Emerging evidences demonstrated ADSC... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 31, 2021 Category: Stem Cells Authors: Yan Li, Jian Zhang, Jihong Shi, Kaituo Liu, Xujie Wang, Yanhui Jia, Ting He, Kuo Shen, Yunchuan Wang, Jiaqi Liu, Wei Zhang, Tongtao Wang, Zhao Zheng and Dahai Hu Tags: Research Source Type: research

Therapeutic potential of small extracellular vesicles derived from lipoma tissue in adipose tissue regeneration —an in vitro and in vivo study
To explore the adipogenic effects of the small extracellular vesicles derived from the lipoma tissues (sEV-LT), and to find a new cell-free therapeutic approach for adipose tissue regeneration. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 31, 2021 Category: Stem Cells Authors: Pengyu Hong, Xiaoyang Xu, Xin Hu, Hao Yang, Yue Wu, Juan Chen, Kun Li and Zhangui Tang Tags: Research Source Type: research

The adipose-derived mesenchymal stem cell secretome promotes hepatic regeneration in miniature pigs after liver ischaemia-reperfusion combined with partial resection
Hepatic ischaemia-reperfusion injury (HIRI) is inevitable in complicated liver surgery and is a major factor leading to postoperative complications and liver dysfunction. Studies have shown that the paracrine ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 30, 2021 Category: Stem Cells Authors: Zhihui Jiao, Yajun Ma, Qianzhen Zhang, Yue Wang, Tao Liu, Xiaoning Liu, Chenxi Piao, Boyang Liu and Hongbin Wang Tags: Research Source Type: research

The effect of bone marrow-derived mesenchymal stem cell co-transplantation with hematopoietic stem cells on liver fibrosis alleviation and survival in patients with class III β-thalassemia major
Hepatic fibrosis is a common complication in transfusion-dependent thalassemia patients. Data on the co-transplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) in beta-thalassemia... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 29, 2021 Category: Stem Cells Authors: Tahereh Rostami, Amir Kasaeian, Nasrollah Maleki, Mohsen Nikbakht, Azadeh Kiumarsi, Seyed Mohammad Tavangar, Amir Pejman Hashemi Taheri, Seied Asadollah Mousavi and Ardeshir Ghavamzadeh Tags: Research Source Type: research

Transplantation of human induced pluripotent stem cell-derived neural crest cells for corneal endothelial regeneration
The corneal endothelium maintains corneal hydration through the barrier and pump function, while its dysfunction may cause corneal edema and vision reduction. Considering its development from neural crest cell... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 29, 2021 Category: Stem Cells Authors: Yajie Gong, Haoyun Duan, Xin Wang, Can Zhao, Wenjing Li, Chunxiao Dong, Zongyi Li and Qingjun Zhou Tags: Research Source Type: research

miR-133a silencing rescues glucocorticoid-induced bone loss by regulating the MAPK/ERK signaling pathway
Dysfunction of mesenchymal stem cells (MSCs) is recognized as critical to the pathogenesis of glucocorticoid-induced osteoporosis (GIO), suggesting the potential of MSC-targeting interventions for this disorde... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 29, 2021 Category: Stem Cells Authors: Gang Wang, Fengbin Wang, Lecheng Zhang, Chao Yan and Yuelei Zhang Tags: Research Source Type: research

Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6 –p-STAT3–p63–JAG2 pathway
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are syndromes of acute respiratory failure with extremely high mortality and few effective treatments. Mesenchymal stem cells (MSCs) may r... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 29, 2021 Category: Stem Cells Authors: Wenjun Peng, Meijia Chang, Yuanyuan Wu, Wensi Zhu, Lin Tong, Ge Zhang, Qin Wang, Jie Liu, Xiaoping Zhu, Tingting Cheng, Yijia Li, Xi Chen, Dong Weng, Sanhong Liu, Hongwei Zhang, Yao Su & hellip; Tags: Research Source Type: research

Any closer to successful therapy of multiple myeloma? CAR-T cell is a good reason for optimism
Despite many recent advances on cancer novel therapies, researchers have yet a long way to cure cancer. They have to deal with tough challenges before they can reach success. Nonetheless, it seems that recentl... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 29, 2021 Category: Stem Cells Authors: Faroogh Marofi, Safa Tahmasebi, Heshu Sulaiman Rahman, Denis Kaigorodov, Alexander Markov, Alexei Valerievich Yumashev, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Rebar N. Mohammed, Mostafa Jarahian, Roza Motavalli and Farhad Motavalli Khiavi Tags: Review Source Type: research

Natural killer cell therapy for hematologic malignancies: successes, challenges, and the future
The adoptive transfer of natural killer (NK) cells is an emerging therapy in the field of immuno-oncology. In the last 3 decades, NK cells have been utilized to harness the anti-tumor immune response in a wide... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 25, 2021 Category: Stem Cells Authors: Margaret G. Lamb, Hemalatha G. Rangarajan, Brian P. Tullius and Dean A. Lee Tags: Review Source Type: research

Applications and therapeutic mechanisms of action of mesenchymal stem cells in radiation-induced lung injury
Radiation-induced lung injury (RILI) is one of the most common complications associated with radiotherapy, characterized by early-stage radiation pneumonia and subsequent radiation pulmonary fibrosis. However,... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 25, 2021 Category: Stem Cells Authors: Shiying Niu and Yueying Zhang Tags: Review Source Type: research

Role of glioblastoma stem cells in cancer therapeutic resistance: a perspective on antineoplastic agents from natural sources and chemical derivatives
Glioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior. Despite significant advances in dia... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 24, 2021 Category: Stem Cells Authors: Ana Laura V. Alves, Izabela N. F. Gomes, Adriana C. Carloni, Marcela N. Rosa, Luciane S. da Silva, Adriane F. Evangelista, Rui Manuel Reis and Viviane Aline O. Silva Tags: Review Source Type: research