Association of Body Mass Index with Mortality in Patients with Cardiogenic Shock following Acute Myocardial Infarction: A Contemporary Danish Cohort Analysis
Conclusions: Thirty-day mortality in patients with AMICS was not associated with the BMI category. Thus, evidence of an “obesity paradox” was not observed in this contemporary cohort of patients with AMICS in Denmark.Cardiology (Source: Cardiology)
Source: Cardiology - July 20, 2021 Category: Cardiology Source Type: research

Timing of Nonculprit Percutaneous Coronary Intervention after ST-Elevation Myocardial Infarction
Conclusions: Patients with MVD are at increased risk of experiencing MACE after revascularization of nonculprit vessels with increasing time delay between pPCI and sPCI.Cardiology (Source: Cardiology)
Source: Cardiology - July 20, 2021 Category: Cardiology Source Type: research

Performance of a Novel Research-Use-Only Secretoneurin ELISA in Patients with Suspected Acute Coronary Syndrome: Comparison with an Established Secretoneurin Radioimmunoassay
Conclusions: The novel SN ELISA has excellent performance, higher AUC for diagnosis, and superior prognostic accuracy compared to the established RIA in chest pain patients.Cardiology (Source: Cardiology)
Source: Cardiology - July 20, 2021 Category: Cardiology Source Type: research

Safety and Efficacy of Ibutilide for Acute Pharmacological Cardioversion of Rheumatic Atrial Fibrillation
Conclusion: Ibutilide cardioverted 77% of rheumatic AF to sinus rhythm, indicating its potential as a clinically useful option for pharmacological cardioversion of rheumatic AF. TdP is a potentially serious adverse event that requires careful monitoring.Cardiology (Source: Cardiology)
Source: Cardiology - July 15, 2021 Category: Cardiology Source Type: research

A novel SCN5A variant causes temperature-sensitive loss-of-function in a family with symptomatic Brugada syndrome, cardiac conduction disease and sick sinus syndrome
(Source: Cardiology)
Source: Cardiology - July 8, 2021 Category: Cardiology Source Type: research

High-Normal Thyroid Function and Recurrence of Atrial Fibrillation after Catheter Ablation: A Prospective Observational Study
Conclusions: High-normal FT3 and FT4 levels are associated with AF recurrence after catheter ablation in this Chinese population. Attention to thyroid hormones could be valuable to assist in the management of AF.Cardiology (Source: Cardiology)
Source: Cardiology - July 8, 2021 Category: Cardiology Source Type: research

Comparing the Prognostic Impact of Prediabetes with Diabetes in a Nationwide Cohort of Patients with Chronic Coronary Syndromes: An Analysis of the START Registry
Conclusions: The risk of 1-year major events among patients with CCS and pre-DM is comparable to that of patients with CCS and normoglycemic status and is lower than that of patients with DM.Cardiology (Source: Cardiology)
Source: Cardiology - July 7, 2021 Category: Cardiology Source Type: research

Radiation Safety and Electrophysiologists: Radiation Protection Status – Go for Zero Fluoroscopy European Heart Rhythm Association Registry
Conclusions: Electrophysiologists ’ radiation-protective devices for occupational exposure are similar across European centers and in accordance with the applicable X-ray protection protocols, irrespective of the level of experience, number of monthly performed EP procedures, and gender.Cardiology (Source: Cardiology)
Source: Cardiology - July 2, 2021 Category: Cardiology Source Type: research

People Cannot Discover New Lands until They Have the Courage to Lose Sight of the Shore: Stress Echocardiography in Left Ventricular Outflow Obstruction
Cardiology (Source: Cardiology)
Source: Cardiology - July 1, 2021 Category: Cardiology Source Type: research

Percentage of Age-Predicted Cardiorespiratory Fitness Is Inversely Associated with Cardiovascular Disease Mortality: A Prospective Cohort Study
Conclusion: Percentage of age-predicted CRF is inversely and independently associated with CVD mortality in a graded fashion and significantly improves the prediction and classification of the long-term risk for CVD mortality beyond established risk factors.Cardiology (Source: Cardiology)
Source: Cardiology - July 1, 2021 Category: Cardiology Source Type: research

Non-culprit artery myocardial infarction and complex coronary lesions in anterior ST-elevated myocardial infarction patients.
(Source: Cardiology)
Source: Cardiology - June 30, 2021 Category: Cardiology Source Type: research

The Role of Color Doppler Ultrasonography in the Perioperative Period of Coronary Artery Bypass Grafting: Comparison with Transit-Time Flow Measurement
Conclusions: The MGF and PI by TTFM in CABG were associated with in situ LIMA graft parameters measured by CDUS studies. CDUS is a useful functional noninvasive tool for the preoperative screening and postoperative follow-up of patients with in situ LIMA bypass.Cardiology (Source: Cardiology)
Source: Cardiology - June 30, 2021 Category: Cardiology Source Type: research

Proliferative Vascular Smooth Muscle Cells Stimulate Extracellular Matrix Production via Osteopontin/p38 MAPK Signaling Pathway
Conclusion: OPN, the proliferative VSMCs maker, increased the expression of extracellular matrix. OPN/p38 MAPK signaling pathways may protect against ascending aortic aneurysm progression.Cardiology (Source: Cardiology)
Source: Cardiology - June 29, 2021 Category: Cardiology Source Type: research

Acute kidney injury in patients with acute coronary syndrome after percutaneous coronary intervention: pathophysiologies, risk factors and preventive measures
(Source: Cardiology)
Source: Cardiology - June 24, 2021 Category: Cardiology Source Type: research

Use of the HAVOC Score to Identify Patients at Highest Risk of Developing Atrial Fibrillation
(Source: Cardiology)
Source: Cardiology - June 22, 2021 Category: Cardiology Source Type: research

Undetectable High-sensitivity Troponin T as a Gatekeeper for Coronary CT Angiography in Patients Suspected of Acute Coronary Syndrome.
(Source: Cardiology)
Source: Cardiology - June 18, 2021 Category: Cardiology Source Type: research

The Effect of Atrial Fibrillation on the Long-Term Mortality of Patients with Acute Coronary Syndrome: The TACOS Study
Conclusion: AF/atrial flutter at admission and/or discharge independently predicted poorer long-term outcome in ACS patients, with 66% higher mortality within the ≥10-year follow-up time when compared to patients with SR.Cardiology (Source: Cardiology)
Source: Cardiology - June 16, 2021 Category: Cardiology Source Type: research

Association of Acute Kidney Injury with Outcomes in Patients Undergoing Transcatheter Mitral Valve Repair
Conclusion: AKI in the setting of TMVr is common and is associated with worse clinical outcomes. Further studies are needed to determine if optimizing renal function prior to TMVr may improve outcomes, as well as to understand the impact of TMVr itself on renal function.Cardiology (Source: Cardiology)
Source: Cardiology - June 15, 2021 Category: Cardiology Source Type: research

Comparison of Aortic Gradient and Ventricular Mass after Valve Replacement for Aortic Stenosis with Rapid Deployment, Sutureless, and Conventional Bioprostheses
Conclusions: We observed differences in haemodynamic, electrocardiographic, and echocardiographic parameters related to the different types of prosthesis. Patients with the Intuity ® prosthesis had the highest reduction in peak aortic gradient and the higher ventricular mass regression. Besides, patients with the Intuity® prosthesis had less risk of mortality during follow-up than the other two groups. Further studies are needed to confirm these findings.Cardiology (Source: Cardiology)
Source: Cardiology - June 11, 2021 Category: Cardiology Source Type: research

Safety of High-Dose Dabigatran in Elderly and Younger Patients with a Low Bleeding Risk: A Prospective Observational Study
Conclusions: Our results suggest that Dabigatran 150 mg twice a day can be safely used among elderly AF patients with low bleeding risk.Cardiology (Source: Cardiology)
Source: Cardiology - June 11, 2021 Category: Cardiology Source Type: research

The Role of Interleukin-27 in Atherosclerosis: A Contemporary Review
Atherosclerosis is a chronic inflammation characterized by an imbalance between inhibitors and stimulators of the inflammatory system that leads to the formation of atherosclerotic plaques in the vessel walls. Interleukin (IL)-27 is one of the recently discovered cytokines that have an immunomodulatory role in autoimmune and inflammatory diseases. However, the definite role of IL-27 in the pathogenesis of atherosclerosis remains unclear. Recent studies on cardiomyocytes and vascular endothelium have demonstrated mechanisms through which IL-27 could potentially modulate atherosclerosis. Upregulation of the IL-27 receptor wa...
Source: Cardiology - May 19, 2021 Category: Cardiology Source Type: research

Usefulness of Stress Echocardiography in Assessment of Dynamic Left Ventricular Obstructions: Case Series and Review of the Literature
Dynamic left ventricular outflow tract obstruction (DLVOTO) or midcavity obstruction in patients with structurally normal hearts is not uncommon in routine clinical practice and can cause significant symptoms mimicking coronary artery disease or heart failure. Although exercise echocardiography is the gold standard for assessing DLVOTO, dobutamine stress echocardiography (DSE) may be valuable diagnostic modality in patients who are unable to exercise or have an uninterpretable 12-lead electrocardiogram. We provide an updated overview of the relevant literature regarding prevalence, pathophysiology, clinical significance, a...
Source: Cardiology - May 18, 2021 Category: Cardiology Source Type: research

Incremental Value of Renal Dysfunction Addition to the CHA2DS2-Vasc Score for Mortality Prediction in Patients with Acute Coronary Syndrome
Conclusions: CHA2DS2-VASc score demonstrated a good predictive accuracy for IHM and PDM in ACS patients. The addition of renal dysfunction to the original score has the potential to improve identification of patients at the risk of death.Cardiology (Source: Cardiology)
Source: Cardiology - May 7, 2021 Category: Cardiology Source Type: research

The CHA < sub > 2 < /sub > DS < sub > 2 < /sub > -VASc Score and Its Association with Long-Term Outcome in a Cardiac Resynchronization Therapy Population
Conclusion: When tested for association with outcome in a CRT population, the CHA2DS2-VASc score correlates to increased mortality and risk of heart failure hospitalization. It performs similarly to CRT-specific scores. However, the results of this study indicate that all tested scores should be used with caution in CRT patients.Cardiology (Source: Cardiology)
Source: Cardiology - May 7, 2021 Category: Cardiology Source Type: research

Protective Effects of ACEI/ARB on Left Ventricular Function in Anthracycline-Induced Chronic Cardiotoxicity: A Meta-Analysis of Randomized Controlled Trials
Conclusions: We found that prophylactic use of ACEI/ARB reduced the clinical or subclinical cardiotoxicity of anthracycline, and the increase in hypotensive events was not significant. Due to the relatively small number of clinical studies and participants, more related studies are necessary to further verify our results.Cardiology (Source: Cardiology)
Source: Cardiology - May 4, 2021 Category: Cardiology Source Type: research

Long-Term and Short-Term Prognostic Value of Circulating Soluble Suppression of Tumorigenicity-2 Concentration in Chronic Heart Failure: A Systematic Review and Meta-Analysis
Conclusion: Higher sST2 concentration at baseline is associated with increasing risk of long-term ACM, ACM/HFR, and CVM/HFH and can be a tool for the prognosis of chronic heart failure.Cardiology (Source: Cardiology)
Source: Cardiology - April 26, 2021 Category: Cardiology Source Type: research

Geographical Differences in Cardiovascular Comorbidities and Outcomes of COVID-19 Hospitalized Patients in the USA
Conclusions: Geographical differences, including practice pattern variations and the impact of disease burden on provision of health care, are important for the evaluation of COVID-19 outcomes. Unadjusted data may cause bias affecting future regulatory policies and proper allocation of resources.Cardiology (Source: Cardiology)
Source: Cardiology - April 26, 2021 Category: Cardiology Source Type: research

Age-Stratified Outcome in Treatment of Left Main Coronary Artery Stenosis: A NOBLE Trial Substudy
Conclusions: As the overall NOBLE results show revascularization of LMCA disease, age of 67 years or older was associated with lower 5-year MACCE after CABG compared to PCI. Clinical outcomes were not significantly different in the subgroup younger than 67 years, although no significant interaction was present between age and treatment. Mortality was similar for all subgroups (ClinicalTrials.gov identifier: NCT01496651).Cardiology (Source: Cardiology)
Source: Cardiology - April 13, 2021 Category: Cardiology Source Type: research

Utility of Caudal Angulation for Venous Access under Fluoroscopic Guidance during Cardiovascular Implantable Electronic Device Implantation
Conclusions: The proposed advantages of caudal fluoroscopy for CIED implantation have been elucidated by analysis of CT angiography images, contrast venograms, and fluoroscopic images.Cardiology (Source: Cardiology)
Source: Cardiology - April 13, 2021 Category: Cardiology Source Type: research

Association between 10-Year Atherosclerotic Cardiovascular Disease Risk and Vascular Endothelial Function in Patients with Vasospastic Angina
Conclusions: Unlike mCAD and sCAD, we found no correlation between 10Y-ASCVDR and endothelial function in VA. Thus, our results support that FMD is not a good marker of atherosclerotic cardiovascular risk in VA.Cardiology (Source: Cardiology)
Source: Cardiology - April 13, 2021 Category: Cardiology Source Type: research

Chikungunya and the Heart
Conclusion: Although most cases are rarely fatal, CV involvement in chikungunya infection remains the most frequent atypical presentation of this disease and may have severe manifestations. Timely diagnosis and appropriate management are necessary to improve patient outcomes.Cardiology (Source: Cardiology)
Source: Cardiology - March 31, 2021 Category: Cardiology Source Type: research

Distal Radial Artery Cannulation for Challenging Radial Anatomy
Cardiology (Source: Cardiology)
Source: Cardiology - March 30, 2021 Category: Cardiology Source Type: research

Efficacy and Safety of Sacubitril/Valsartan Therapy for Acute Decompensated Heart Failure with Reduced Ejection Fraction during the Vulnerable Phase: A Multicenter, Assessor-Blinded, Prospective, Observational, Cohort Study
Conclusions: Among patients hospitalized with ADHF and reduced left ventricular ejection fraction, we observed that sacubitril/valsartan therapy led to reduction in death from cardiovascular causes and rehospitalizations for heart failure when compared to ACEI/ARB therapy alone during the vulnerable phase. Our results support that sacubitril/valsartan may be administered early in the vulnerable phase after ADHF and improves NYHA class.Cardiology (Source: Cardiology)
Source: Cardiology - March 29, 2021 Category: Cardiology Source Type: research

Relation between Baseline Coronary Atherosclerotic Status, Cardiovascular Events, and Malignancies in Type 2 Diabetics: A Long-Term Prospective Cohort Study
Conclusion: This study found no relation between extent of coronary atherosclerosis or incidence of CV events and malignancy. Malignancy surpassed CV disease as the commonest long-term cause of mortality in middle-aged and older diabetics.Cardiology (Source: Cardiology)
Source: Cardiology - March 26, 2021 Category: Cardiology Source Type: research

Triflusal in Patients with Acute Coronary Syndrome and Acetylsalicylic Acid Hypersensitivity
Conclusion: In this series of patients presenting with ACS and ASA hypersensitivity, triflusal showed good tolerability and was associated with a low rate of CV and bleeding events.Cardiology (Source: Cardiology)
Source: Cardiology - March 23, 2021 Category: Cardiology Source Type: research

The Prognostic Value of Left Atrial Global Longitudinal Strain and Left Atrial Phasic Volumes in Patients Undergoing Transcatheter Valve Implantation for Severe Aortic Stenosis
Conclusion: Within 6 months after TAVI, there is reverse LA remodeling and an improvement in LA reservoir function. Pre- and post-TAVI indices of LA function and volume remain independently associated with MACE. Larger studies enrolling a greater diversity of patients may provide sufficient evidence for the utilization of these imaging biomarkers in clinical practice.Cardiology (Source: Cardiology)
Source: Cardiology - March 22, 2021 Category: Cardiology Source Type: research

Impact of Perioperative Tachydysrhythmias on Mortality and Length of Stay in Complete Repair of Tetralogy of Fallot: A Multicenter Retrospective Cohort Study from the Pediatric Health Information System
Conclusion: After complete repair of TOF, TDS were not associated with mortality and appeared to have only a modest effect on LOS.Cardiology (Source: Cardiology)
Source: Cardiology - March 18, 2021 Category: Cardiology Source Type: research

Leaks after Left Atrial Appendage Closure: Ignored or Neglected?
Left atrial appendage (LAA) closure has recently been approved as an alternative management for stroke prevention in patients with chronic atrial fibrillation who have difficulties with long-term oral anticoagulation. The various shapes and sizes of LAA and orientation of the atrial ostium may contribute to the incomplete LAA closure from circular design devices and orientation of the non-steerable delivery catheter. Incomplete closure of LAA leads to a high-velocity blood flow through the peri-device gap, resulting in peri-device leak (PDL). Residual leaks are frequently diagnosed after LAA closure procedures, regardless ...
Source: Cardiology - March 18, 2021 Category: Cardiology Source Type: research

National Cardiovascular Data Registry Model Predicts Long-Term Mortality in Patients Undergoing Percutaneous Coronary Interventions
National Cardiovascular Data Registry (NCDR)-based logistic regression model is available for clinicians to predict in-hospital all-cause mortality after a percutaneous coronary intervention (PCI). However, this model has never been used to predict long-term all-cause mortality after PCI. Therefore, we sought to test the ability of the NCDR model to predict the short- and long-term risk of all-cause mortality in patients undergoing PCI. All patients undergoing PCI in the Mayo Clinic Health System were enrolled in the Mayo Clinic CathPCI registry. Patient-level demographic, clinical, and angiographic data from January 2006 ...
Source: Cardiology - March 18, 2021 Category: Cardiology Source Type: research

On-Demand Mobile Health Infrastructure for Remote Rhythm Monitoring within a Wait-and-See Strategy for Recent-Onset Atrial Fibrillation: TeleWAS-AF
Recently, we introduced the TeleCheck-AF approach, an on-demand mobile health (mHealth) infrastructure using app-based heart rate and rhythm monitoring for 7 days, to support long-term atrial fibrillation (AF) management through teleconsultation. Herein, we extend the mHealth approach to patients with recent-onset AF at the emergency department (ED). In the proposed TeleWAS-AF approach, on-demand heart rate and rhythm monitoring are used to support a wait-and-see strategy at the ED. All stable patients who present to the ED with recent-onset symptomatic AF and who are able to use mHealth solutions for heart rate and rhythm...
Source: Cardiology - March 18, 2021 Category: Cardiology Source Type: research

Potential of Circulating Proangiogenic MicroRNAs for Predicting Major Adverse Cardiac and Cerebrovascular Events in Unprotected Left Main Coronary Artery Disease Patients Who Underwent Coronary Artery Bypass Grafting
Conclusion: Measurement of circulating proangiogenic miRNAs especially miR-let-7f, miR-19a, miR-126, miR-130a, and miR-378 helps predict MACCE risk in ULMCAD patients who underwent CABG.Cardiology (Source: Cardiology)
Source: Cardiology - March 17, 2021 Category: Cardiology Source Type: research

The Relationship between Adult Height and Blood Pressure
Conclusion: Physiological studies and epidemiological data suggest a potential inverse association between adult height and blood pressure. Further research is required to define the relationship more clearly between adult height and blood pressure and to assess whether antihypertensive therapeutic approaches and goals should be modified according to patients ’ heights.Cardiology (Source: Cardiology)
Source: Cardiology - March 15, 2021 Category: Cardiology Source Type: research

Research Article: Management of Pulmonary Embolism: Results from the German Chest Pain Unit Registry
Conclusion: This study suggests a certain risk for underdiagnosis and consecutive potential undertreatment of PE patients in German Cardiac Society (GCS)-certified CPUs, which is thought to result from an anticipated focus on patients with acute coronary syndrome (ACS). Public awareness for PE beyond chest pain should be improved. Certified CPUs should be urged to implement strategic pathways for a better simultaneous diagnostic workup of differential diagnosis beyond ACS.Cardiology (Source: Cardiology)
Source: Cardiology - March 10, 2021 Category: Cardiology Source Type: research

Analyses of Increased Mortality in New and Known Diabetes in Patients with Coronary Disease Enrolled in the NORSTENT Randomized Study
Conclusion: Known diabetes has increased cardiac and noncardiac mortality in contrast to new diabetes which is only associated with increased noncardiac mortality during the 5-year follow-up. Diabetic and nondiabetic patients have the same response to the treatment with BMS or DES.Cardiology (Source: Cardiology)
Source: Cardiology - March 10, 2021 Category: Cardiology Source Type: research

Temporary Trends in Fever following Transcatheter Aortic Valve Implantation
Conclusions: Fever incidence post TAVI decreased significantly throughout the last decade. The higher rate of fever in the early years of TAVI was likely associated with first-generation devices, vascular complications, and reduced GFR.Cardiology (Source: Cardiology)
Source: Cardiology - March 10, 2021 Category: Cardiology Source Type: research

Serum Individual Nonesterified Fatty Acids and Risk of Heart Failure in Older Adults
Conclusion: Our data are consistent with a higher risk of HF with nonesterified stearic and nervonic acids and a lower risk with nonesterified 15:0, GLA, and DHA in older adults. If confirmed in other studies, specific NEFAs may provide new targets for HF prevention.Cardiology (Source: Cardiology)
Source: Cardiology - February 25, 2021 Category: Cardiology Source Type: research

Challenges in Evaluation and Management of Children with Myocardial Bridging
Myocardial bridging (MB) is a congenital anomaly where a coronary artery branch or group of branches extends inside a tunnel consisting of myocardium. Although it is mostly considered “benign,” it is reported that MB may lead to significant cardiac problems and sudden cardiac deaths. While it is a congenital anomaly, its symptoms usually arise at further ages rather than childhood. The literature on MB in children is in the form of case reports or small case series. This is w hy pediatric cases are assessed in the light of information obtained from adults. This review compiled the literature on MB in adults and...
Source: Cardiology - February 25, 2021 Category: Cardiology Source Type: research

Anthracycline-Induced Cardiotoxicity: The Role of Endothelial Dysfunction
The objectives of this study were to evaluate prognostic role of molecular (endothelin-1) and genetic factors (gene polymorphisms of endothelial nitric oxide (NO) synthase (NOS3, rs1799983), endothelin-1 receptor type A (EDNRA, C+70G, rs5335) and NADPH oxidase (C242T, rs4673) in development of endothelial dysfunction and anthracycline-induced cardiotoxicity in women without cardiovascular diseases.Cardiology (Source: Cardiology)
Source: Cardiology - February 17, 2021 Category: Cardiology Source Type: research

The Association between Serum Heme Oxygenase-1 Levels and Coronary SYNTAX Score
Conclusion: In this study, serum HO-1 levels were significantly associated with the coronary SYNTAX score.Cardiology (Source: Cardiology)
Source: Cardiology - February 15, 2021 Category: Cardiology Source Type: research

Patent Foramen Ovale Closure among Patients with Hypercoagulable States Maintained on Antithrombotic Therapy
Conclusions: Among patients with HCSs maintained on anticoagulant or antiplatelet therapies, PFO closure was associated with a significantly lower risk of CVA or TIA.Cardiology (Source: Cardiology)
Source: Cardiology - February 12, 2021 Category: Cardiology Source Type: research