Transcatheter Mitral Valve Repair in Patients with Heart Failure: A Meta-Analysis
Conclusion: Evidence from pooled analysis suggests that transcatheter mitral valve repair using MitraClip on top of medical therapy, in appropriately selected symptomatic heart failure patients with significant secondary MR, provides survival benefit and may decrease hospitalizations when compared with guideline-directed medical therapy alone.Cardiology (Source: Cardiology)
Source: Cardiology - December 1, 2020 Category: Cardiology Source Type: research

Assessing the Performance of a Novel Point-of-Care Qualitative Assay for Early Diagnosis of Acute Coronary Syndrome
Conclusions: Upon first medical contact, the novel point-of-care rapid SensAheart assay shows a diagnostic performance similar to hs-cTnT. The combination of 2 cardiac biomarkers in the same kit allows for very early detection of myocardial damage. The SensAheart assay is a reliable and practical tool for ruling-in the diagnosis of ACS.Cardiology (Source: Cardiology)
Source: Cardiology - November 30, 2020 Category: Cardiology Source Type: research

Clinical Presentation, Diagnosis, and Management of Idiopathic Enlargement of the Right Atrium: An Analysis Based on Systematic Review of 153 Reported Cases
In conclusion, IERA, although rare, tends to be associated with potential life-threatening complications and sudden cardiac death. Echocardiography is the most common diagnostic modality. Surgical resection is indicated for symptomatic patients.Cardiology (Source: Cardiology)
Source: Cardiology - November 26, 2020 Category: Cardiology Source Type: research

Percutaneous Left Atrial Appendage Occlusion
Cardiology (Source: Cardiology)
Source: Cardiology - November 26, 2020 Category: Cardiology Source Type: research

Relation between Accumulated Air Pollution Exposure and Sub-Clinical Cardiovascular Disease in 33,723 Danish 60 –74-Year-Old Males from the Background Population (AIR-CARD): A Method Article
Cardiovascular disease is one of the main causes of death and disability in the Western world, and there is increasing evidence that air pollution is a risk factor for developing sub-clinical cardiovascular diseases. Previous studies have shown a correlation between cardiovascular disease and short-term exposure to elevated air pollution levels. However, the literature on the impact of long-term effect of air pollution is limited. We have a unique opportunity to evaluate this correlation. The DEHM/UBM/AirGIS model system calculates air pollution in a high temporal and spatial resolution and traces air pollution retrospecti...
Source: Cardiology - November 25, 2020 Category: Cardiology Source Type: research

Clinical Significance of Guanylate Cyclase Stimulator, Riociguat, on Right Ventricular Functional Improvement in Patients with Pulmonary Hypertension
Conclusions: Riociguat not only improved the hemodynamics of patients with PH but also ameliorated the echocardiographic parameters with RV function. RV strain could detect the subtle improvement in mild PH, and riociguat may have a benefit even after intervention, as assessed by speckle-tracking echocardiography.Cardiology (Source: Cardiology)
Source: Cardiology - November 25, 2020 Category: Cardiology Source Type: research

The Late Effects of Pregnancy on Aortic Dimensions in Patients with Marfan Syndrome
While the immediate effects of pregnancy on aortic dimension in patients with Marfan syndrome (MFS) have been evaluated, the late effects of subsequent pregnancies in these patients are less known. For this purpose, we evaluated 2 groups of women with MFS who were under specialized care in our institution. Group A included 23 women with MFS who experienced 55 pregnancies; group B included 12 nulliparous MFS patients. Patients in group A were similar in age (36.13 ± 5.6 years vs. 34.25 ± 6.54 years,p = 0.41) and follow-up time (group A 6.05 ± 3.56 years and group B 4.92 ± 3.37 years,p = 0.37). Ba...
Source: Cardiology - November 25, 2020 Category: Cardiology Source Type: research

Outcome of Insertable Cardiac Monitors in Symptomatic Patients with Brugada Syndrome at Low Risk of Sudden Cardiac Death
Cardiology (Source: Cardiology)
Source: Cardiology - November 25, 2020 Category: Cardiology Source Type: research

Adequate Decongestion Is Still the Question in Heart Failure
Cardiology (Source: Cardiology)
Source: Cardiology - November 24, 2020 Category: Cardiology Source Type: research

The Degree of the Predischarge Pulmonary Congestion in Patients Hospitalized for Worsening Heart Failure Predicts Readmission and Mortality
Conclusion: The degree of predischarge PC assessed by ∆LIR is the most dominant predictor of TTR and TTD.Cardiology (Source: Cardiology)
Source: Cardiology - October 28, 2020 Category: Cardiology Source Type: research

Effect of Combined Statin and Antihypertensive Therapy in Patients with Hypertension: A Systematic Review and Meta-Analysis
Conclusion: These findings suggested that combined statin and antihypertensive therapy was associated with more cardiovascular benefits compared with antihypertensive therapy alone.Cardiology (Source: Cardiology)
Source: Cardiology - October 28, 2020 Category: Cardiology Source Type: research

Prognostic Impact of the Pulmonary Artery Pulsatility Index in Patients with Chronic Heart Failure and Severe Mitral Regurgitation Undergoing Percutaneous Edge-to-Edge Repair
Conclusions: PAPi is strongly associated with clinical outcome among patients with CHF and functional MR undergoing TMVR. A PAPi value ≤2.46 predicts a worse prognosis independent of other important clinical, echocardiographic, and hemodynamic factors. Therefore, PAPi may serve as a new parameter to improve patient selection for TMVR.Cardiology (Source: Cardiology)
Source: Cardiology - October 22, 2020 Category: Cardiology Source Type: research

Pre- and Post-Transcatheter Aortic Valve Replacement Serum Brain Natriuretic Peptide Levels and All-Cause Mortality
Conclusions: Serum BNP levels 24 h post-procedure were found to be a meaningful marker in predicting 1-year all-cause mortality in patients after TAVR procedure.Cardiology (Source: Cardiology)
Source: Cardiology - October 16, 2020 Category: Cardiology Source Type: research

Carcinoid Heart Disease: Pathophysiology, Pathology, Clinical Manifestations, and Management
Carcinoid heart disease (CHD) is a rare and potentially lethal manifestation of an advanced carcinoid (neuroendocrine) tumor. The pathophysiology of CHD is related to vasoactive substances secreted by the tumor, of which serotonin is most prominent in the pathophysiology of CHD. Serotonin stimulates fibroblast growth and fibrogenesis, which can lead to cardiac valvular fibrosis. CHD primarily affects right heart valves, causing tricuspid and pulmonic regurgitation and less frequently stenosis of these valves. Left heart valves are usually spared because vasoactive substances such as serotonin are enzymatically inactivated ...
Source: Cardiology - October 16, 2020 Category: Cardiology Source Type: research

Genetic Spectrum of Left Ventricular Non-Compaction in Paediatric Patients
Conclusion: We detected a low burden of contractile sarcomeric variants in LVNC patients presenting below the age of 18 years, with the major number of variants residing in non-contractile structural sarcomeric genes. The identification of the variants in ion-channel and related genes not previously associated with LVNC in paediatric patients requires further examination of their functional role.Cardiology (Source: Cardiology)
Source: Cardiology - October 13, 2020 Category: Cardiology Source Type: research

A Prospective Registry of Atrial Fibrillation Ablation with the Ablation Index Technology: Rationale and Study Design
This is a prospective multicenter registry of atrial fibrillation (AF) ablation with the Ablation Index (AI) technology, which has been introduced as a marker predicting ablation lesion depth. The index incorporates the main parameters of radiofrequency point-by-point ablation: power, contact force, and time of ablation. The AI is calculated for every operator depending on personal skills, and there are no strict indications on the range of the parameter considering its safety and efficacy during pulmonary vein isolation. The registry aims to evaluate AI values used in different centers by different operators and to evalua...
Source: Cardiology - October 9, 2020 Category: Cardiology Source Type: research

Coronary Collateral Microcirculation Reserve Becomes Vestigial with Aging
Conclusion: Aging causes CCMR decline in rats.Cardiology (Source: Cardiology)
Source: Cardiology - October 8, 2020 Category: Cardiology Source Type: research

Assessing the Validity of Echocardiographic Criteria for Left Ventricular Diastolic Dysfunction in Patients with Pulmonary Hypertension
Conclusion: Our study suggests E/average e ’ may be the only reliable tissue Doppler parameter of LV diastolic dysfunction in patients with PHT, and that septal e’ is paradoxically decreased in patients with PHT and normal left-sided filling pressures.Cardiology (Source: Cardiology)
Source: Cardiology - October 8, 2020 Category: Cardiology Source Type: research

Plasma Somatostatin in Advanced Heart Failure: Association with Cardiac Filling Pressures and Outcome
Conclusions: Somatostatin concentrations were associated with CVP and CI in patients with HF. The pathophysiological mechanism may be related to congestion and/or hypoperfusion of the intestine. Somatostatin was an independent predictor of mortality in advanced HF.Cardiology (Source: Cardiology)
Source: Cardiology - October 7, 2020 Category: Cardiology Source Type: research

Interatrial Block Predicts Atrial Fibrillation and Total Mortality in Patients with Cardiac Resynchronization Therapy
Conclusions: IAB is associated with new-onset AF and death in CRT recipients and may be helpful in the risk stratification in the context of heart failure management. Abnormal PTFV1 did not demonstrate any prognostic value.Cardiology (Source: Cardiology)
Source: Cardiology - October 6, 2020 Category: Cardiology Source Type: research

“Covidsubo”: Stress-Induced Cardiomyopathy by Novel Coronavirus Disease 2019
Conclusion: Physicians and scientists around the globe should be aware of the psychological consequences of COVID-19 and their potential to cause physical illness.Cardiology (Source: Cardiology)
Source: Cardiology - September 28, 2020 Category: Cardiology Source Type: research

Impact of Preprocedural Aortic Valve Calcification on Conduction Disturbances after Transfemoral Aortic Valve Replacement
Conclusion: Orthogonal annular calcification confers an increased risk for conduction disturbances after TAVR. This is even more pronounced after implantation of balloon-expandable valves.Cardiology (Source: Cardiology)
Source: Cardiology - September 23, 2020 Category: Cardiology Source Type: research

Successful Transfemoral Transcatheter Aortic Valve Replacement in a Patient with Double Aortic Arch: An Interesting Imaging Case
We present the case of a patient incidentally found to have a right dominant double aortic arch who underwent successful TAVR for severe aortic stenosis.Cardiology (Source: Cardiology)
Source: Cardiology - September 21, 2020 Category: Cardiology Source Type: research

Vectorcardiography Findings Are Associated with Recurrent Ventricular Arrhythmias and Mortality in Patients with Heart Failure Treated with Implantable Cardioverter-Defibrillator Device
Conclusion: The spatial QRS-T angle and Twvm are emerging VCG indices which are independently associated with mortality in patients with reduced left ventricular ejection fraction due to ICMP or NICMP. Using a composite score of all 3 vector indices, a maximum score was associated with poor long-term survival.Cardiology (Source: Cardiology)
Source: Cardiology - September 21, 2020 Category: Cardiology Source Type: research

Height Is Associated with Dyslipidemia in Korean Premenopausal Women: Data from the Korea National Health and Nutrition Examination Survey
Conclusion: There was a dose-dependent correlation between adult height and adverse lipid profile in premenopausal Korean women who did not have CVD. This finding could serve as further evidence that dyslipidemia can be a link between shortness and CVD.Cardiology (Source: Cardiology)
Source: Cardiology - September 10, 2020 Category: Cardiology Source Type: research

Substantial Value of Cardiac Computed Tomography for the Evaluation of Patients with Suspected Prosthetic Valve Dysfunction
Cardiology (Source: Cardiology)
Source: Cardiology - September 8, 2020 Category: Cardiology Source Type: research

Cardioversion Safety – Are We Doing Enough?
There is a considerable periprocedural risk of thromboembolic events in atrial fibrillation patients undergoing cardioversion, and treatment with anticoagulants is therefore a hallmark of cardioversion safety. Based on retrospective subgroup analyses and prospective studies, non-vitamin K anticoagulants are at least as efficient as vitamin K-antagonists in preventing thromboembolic complications after cardioversion. The risk of thromboembolic complications after cardioversion very much depends on the comorbidities in a given patient, and especially heart failure, diabetes, and age #x3e;75 years carry a markedly increased r...
Source: Cardiology - September 8, 2020 Category: Cardiology Source Type: research

Prognostic Value of Biomarkers in Cardiac Allograft Vasculopathy following Heart Transplantation: A Literature Review
Cardiac allograft vasculopathy (CAV), also known as cardiac transplant vasculopathy, is a major determinant of long-term survival among cardiac transplantation recipients. Histologically, CAV is featured by diffuse, concentric thickening of the vascular wall, and primarily affects large and small epicardial coronary arteries, intramyocardial arteries, and veins. Owing to graft denervation, CAV typically follows an insidious course, and patients may not experience classic angina symptoms but instead present with progressive heart failure or ventricular arrhythmias. Recent studies on biomarkers have furthered the knowledge c...
Source: Cardiology - September 4, 2020 Category: Cardiology Source Type: research

Importance and Assessment of Quality of Life in Symptomatic Permanent Atrial Fibrillation: Patient Focus Groups from the RATE-AF Trial
Conclusions: The impact of comorbidities is poorly appreciated in the context of AF, with considerable variability in QoL that requires both generic and AF-specific assessment. Improvement in QoL should direct the appraisal, and reappraisal, of treatment decisions for patients with permanent AF.Cardiology (Source: Cardiology)
Source: Cardiology - August 28, 2020 Category: Cardiology Source Type: research

One-Year Course of Periprocedural Anticoagulation in Atrial Fibrillation Ablation: Results of a German Nationwide Survey
Conclusion: Our survey shows marked heterogeneous periprocedural OAC management at experienced EP centers in Germany. Whereas continuation of VKA has already been integrated into clinical practice, the majority of centers still use a minimally interrupted NOAC strategy.Cardiology (Source: Cardiology)
Source: Cardiology - August 27, 2020 Category: Cardiology Source Type: research

The Interplay between Features of Plaque Vulnerability and Hemodynamic Relevance of Coronary Artery Stenoses
Conclusion: The current study demonstrated that for a given stenosis geometry, features of plaque vulnerability such as necrotic core volume, TCFA, and positive remodeling may influence the hemodynamic relevance of intermediate coronary stenoses.Cardiology (Source: Cardiology)
Source: Cardiology - August 26, 2020 Category: Cardiology Source Type: research

Elimination of Benign Ventricular Premature Beats or Ventricular Tachycardia with Catheter Ablation versus Two Different Optimal Antiarrhythmic Drug Treatment Regimens (Sotalol or Verapamil/Flecainide)
Background: Symptomatic idiopathic ventricular arrhythmias (VA), including premature beats (VPB) and nonsustained ventricular tachycardia (VT) are commonly encountered arrhythmias. Although these VA are usually benign, their treatment can be a challenge to primary and secondary health care providers. Mainstay treatment is comprised of antiarrhythmic drugs (AAD) and, in case of drug intolerance or failure, patients are referred for catheter ablation to tertiary health care centers. These patients require extensive medical attention and drug regimens usually have disappointing results. A direct comparison between the efficac...
Source: Cardiology - August 25, 2020 Category: Cardiology Source Type: research

A Simplified Two-Stepwise Electrocardiographic Algorithm to Distinguish Left from Right Ventricular Outflow Tract Tachycardia Origin
Conclusions: The combination of TZ index #x3c;0 and V2S/V3R index ≤1.5 is a simple and efficient stepwise electrocardiographic algorithm for predicting LVOT origin. For the OT-VAs with a V3-lead precordial transition, the integration of V2S/V3R index ≤1.5 and R-wave deflection interval in lead V3 #x3e;80 ms would be a better choice.Cardiology (Source: Cardiology)
Source: Cardiology - August 25, 2020 Category: Cardiology Source Type: research

Hypertensive Disorders of Pregnancy and Risk of Cardiovascular Disease-Related Morbidity and Mortality: A Systematic Review and Meta-Analysis
Conclusions: Women with a history of HDP are at an increased risk of future CVD-related morbidity and mortality. Our study highlights the importance of life-long monitoring of cardiovascular risk factors in women with a history of HDP.Cardiology (Source: Cardiology)
Source: Cardiology - August 25, 2020 Category: Cardiology Source Type: research

Advances in Cardiac Computed Tomography Functional Imaging Technology
Cardiovascular disease (CVD) is the leading cause of death among patients in China, and cardiac computed tomography (CT) is one of the most commonly used examination methods for CVD. Coronary artery CT angiography can be used for the morphologic evaluation of the coronary artery. At present, cardiac CT functional imaging has become an important direction of development of CT. At present, common CT functional imaging technologies include transluminal attenuation gradient, stress dynamic CT myocardial perfusion imaging, and CT-fractional flow reserve. These three imaging modes are introduced and analyzed in this review.Cardi...
Source: Cardiology - August 23, 2020 Category: Cardiology Source Type: research

Cardiac CT: A Sine Qua Non for Structural Heart Interventions
Cardiology (Source: Cardiology)
Source: Cardiology - August 23, 2020 Category: Cardiology Source Type: research

Heavy Drinking Habits Are Associated with Worse In-Hospital Outcomes in Patients with Acute Coronary Syndrome: An Insight from the AMIS Plus Registry
Conclusions: Our results support that heavy alcohol consumption is an independent predictor of in-hospital mortality in patients presenting with ACS.Cardiology (Source: Cardiology)
Source: Cardiology - August 20, 2020 Category: Cardiology Source Type: research

A Novel Gain-of-Function < b > < i > KCND3 < /i > < /b > Variant Associated with Brugada Syndrome
In conclusion, a novelKCND3 heterozygous variant was associated with BrS. The increased Ito current explained the critical role ofKCND3 in the pathogenesis of BrS. Genetic screening forKCND3 could be useful for understanding the pathogenesis of BrS and providing effective risk stratification in the clinic.Cardiology (Source: Cardiology)
Source: Cardiology - August 20, 2020 Category: Cardiology Source Type: research

Effectiveness and Safety of the European Society of Cardiology 0-/1-h Troponin Rule-Out Protocol: The Design of the ESC-TROP Multicenter Implementation Study
Chest pain is one of the most common complaints at the emergency department (ED), and it is commonly the perceived likelihood of acute coronary syndrome (ACS) that drives management. Guidelines from the European Society of Cardiology (ESC) recommend the use of a 0-/1-h high-sensitivity cardiac troponin T (hs-cTnT) protocol to rule out or in ACS, but this is mostly based on observational studies. The aim of the ESC-TROP trial is to determine the safety and effectiveness of the ESC 0-/1-h hs-cTnT protocol when implemented in routine care. Adult chest pain patients at 5 EDs in the Sk åne Region, Sweden, are included in ...
Source: Cardiology - August 20, 2020 Category: Cardiology Source Type: research

Transcatheter Closure of Atrial Septal Defects with Cardiac Computed Tomography Sizing: Eight-Year Single-Center Practice
Conclusions: Cardiac CT seems to be comparable to TEE in the assessment of ASD, and transcatheter closure of ASD based on CT sizing alone is safe and feasible.Cardiology (Source: Cardiology)
Source: Cardiology - August 19, 2020 Category: Cardiology Source Type: research

Clinical Outcomes following Left Atrial Appendage Occlusion: A Single-Center Experience
Conclusions: This observational study showed no statistically significant difference in bleeding risk related to initial antithrombotic choice. Smaller device sizes were associated with thromboembolic events, and longitudinal PDL assessment using transesophageal echocardiography showed these frequently do not decrease in size. Larger studies are needed.Cardiology (Source: Cardiology)
Source: Cardiology - August 18, 2020 Category: Cardiology Source Type: research

Two-Hour Post-Load Plasma Glucose, a Biomarker to Improve the GRACE Score in Patients without Known Diabetes
Conclusions: 2h-PG, but not FPG, improves performance of GRS-containing models in predicting post-ACS prognosis in the short to medium term.Cardiology (Source: Cardiology)
Source: Cardiology - August 12, 2020 Category: Cardiology Source Type: research

Gender Differences in Patients Admitted to a Certified German Chest Pain Unit: Results from the German Chest Pain Unit Registry
Conclusion: This study points out gender-specific differences in prehospital time intervals and a significantly higher percentage of atypical symptoms in suspected myocardial ischemia as well as more noncoronary diagnoses in women. Symptom awareness and a broader diagnostic workup in women are essential.Cardiology (Source: Cardiology)
Source: Cardiology - August 11, 2020 Category: Cardiology Source Type: research

Alcohol Consumption and Acute Coronary Syndrome: “In vino Veritas”
Cardiology (Source: Cardiology)
Source: Cardiology - August 7, 2020 Category: Cardiology Source Type: research

Four-Dimensional Volume-Strain Expression in Asymptomatic Primary Hypertension Patients Presenting with Subclinical Left Atrium-Ventricle Dysfunction
Conclusions: LVH patients showed increased LA volumes and decreased LA emptying fractions. LA reservoir, conduit and contractile functions were significantly impaired in LVH patients. Decreased LA conduit function and increased contractile function were revealed in NLVH patients. LA volumetric and functional analyses with 4D volume-strain echocardiography may facilitate the recognition of subtle LA and LV dysfunctions in asymptomatic systemic hypertension patients.Cardiology (Source: Cardiology)
Source: Cardiology - August 5, 2020 Category: Cardiology Source Type: research

Myocardial Infarction with Nonobstructive Coronary Arteries (MINOCA): A Review of the Current Position
Myocardial infarction with nonobstructive coronary arteries (MINOCA) remains a puzzling clinical entity that is characterized by clinical evidence of myocardial infarction (MI) with normal or near-normal coronary arteries on angiography (stenosis #x3c;50%). Major advances in understanding this condition have been made in recent years. The precise pathogenesis is poorly understood and is being studied and examined further. Guidelines indicate that MINOCA is a group of heterogeneous diseases with different mechanisms of pathology. Since there are multiple possible pathological mechanisms, it is not certain that the classical...
Source: Cardiology - August 4, 2020 Category: Cardiology Source Type: research

Comparison of Intravascular Ultrasound Virtual Histology Parameters in Diabetes versus Non-Diabetes with Acute Coronary Syndrome
Conclusion: The DM patients had high-risk plaque composition features like a higher necrotic core, which is a marker of plaque vulnerability. Thus, aggressive medical therapy targeting vascular inflammation using high-dose statins would help in the stabilization of unstable plaque morphology and the reduction of major cardiovascular events.Cardiology (Source: Cardiology)
Source: Cardiology - July 29, 2020 Category: Cardiology Source Type: research

Effects of LCZ696 (Sacubitril/Valsartan) on Blood Pressure in Patients with Hypertension: A Meta-Analysis of Randomized Controlled Trials
Conclusions: The blood pressure-lowering effect of LCZ696 is dose-related. This meta-analysis confirms the antihypertensive effects of LCZ696.Cardiology (Source: Cardiology)
Source: Cardiology - July 29, 2020 Category: Cardiology Source Type: research

Effects of LCZ696 on Blood Pressure in Patients with Hypertension: A Meta-Analysis of Randomized Controlled Trials
Conclusions: The blood pressure-lowering effect of LCZ696 is dose-related. This meta-analysis confirms the antihypertensive effects of LCZ696.Cardiology (Source: Cardiology)
Source: Cardiology - July 29, 2020 Category: Cardiology Source Type: research

Periprocedural Anticoagulation Interruption Strategies for Ablation of Atrial Fibrillation: What Is the Best Current Practice?
Cardiology (Source: Cardiology)
Source: Cardiology - July 22, 2020 Category: Cardiology Source Type: research