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Condition: Rheumatoid Arthritis

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Total 292 results found since Jan 2013.

Methotrexate affects HMGB1 expression in rheumatoid arthritis, and the downregulation of HMGB1 prevents rheumatoid arthritis progression.
This study examined whether HMGB1 might be involved in the treatment of RA using MTX. Synovial tissues were collected from RA patients who were treated with MTX for at least 6 months (RA-MTX group, 7 cases) and from those without MTX treatment (RA-noMTX group, 7 cases). Additionally, patients with osteoarthritis (OA group, 7 cases) were used as controls. The expression and locations of HMGB1 in the tissues were detected using real-time PCR, western blot, and immunohistochemistry. Additionally, OA-fibroblast-like synoviocytes (FLSs) and RA-FLSs were isolated and cultured, and the expression of HMGB1 was reduced in these ce...
Source: Molecular and Cellular Biochemistry - August 12, 2016 Category: Biochemistry Authors: Li YB, Xu P, Xu K, Cai YS, Sun MY, Yang L, Sun J, Lu SM Tags: Mol Cell Biochem Source Type: research

PGK1, a glucose metabolism enzyme, may play an important role in rheumatoid arthritis
Conclusions PGK1, a glycolytic enzyme catalyzing the conversion of 3-phosphoglycerate into 2-phosphoglycerate, has increased expression in synovial tissues and blood of RA, which may be involved in pro-inflammation and synovial hyperplasia of the disease.
Source: Inflammation Research - June 23, 2016 Category: Research Source Type: research

CTGF promotes articular damage by increased proliferation of fibroblast-like synoviocytes in rheumatoid arthritis.
CONCLUSIONS: Our findings indicate that CTGF plays a crucial role in the proliferation of FLS in RA and probably contributes to synovial lining cell hyperplasia and eventually to joint destruction in patients with RA. PMID: 27044368 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - April 3, 2016 Category: Rheumatology Authors: Ding S, Duan H, Fang F, Shen H, Xiao W Tags: Scand J Rheumatol Source Type: research

CD147 promotes the formation of functional osteoclasts through NFATc1 signalling.
Abstract CD147, a membrane glycoprotein of the immunoglobulin superfamily, is highly upregulated during dynamic cellular events including tissue remodelling. Elevated CD147 expression is present in the joint of rheumatoid arthritis patients. However, the role of CD147 in bone destruction remains unclear. To determine whether CD147 is involved in osteoclastogenesis, we studied its expression in mouse osteoclasts and its role in osteoclast differentiation and function. CD147 expression was markedly upregulated during osteoclast differentiation. To investigate the role of CD147 in receptor activator of nuclear factor...
Source: Biochemical and Biophysical Research communications - March 29, 2016 Category: Biochemistry Authors: Nishioku T, Terasawa M, Baba M, Yamauchi A, Kataoka Y Tags: Biochem Biophys Res Commun Source Type: research

Metastasis-associated protein 1 (MTA1) signaling in rheumatoid synovium: Regulation of inflammatory response and cytokine-mediated production of prostaglandin E2 (PGE2).
Abstract Abnormal perpetual inflammatory response and sequential cytokine-induced prostaglandin E2 (PGE2) play important roles in the pathogenesis of rheumatoid arthritis (RA). The underlying regulatory mechanism, however, remain largely unknown. Here, we discovered that expression level of Metastasis associated protein 1 (MTA1), an important chromatin modifier that plays a critical role in transcriptional regulation by modifying DNA accessibility for cofactors, was upregulated in human rheumatoid synovial tissues. Furthermore, a knockdown of MTA1 by siRNA in the human fibroblast-like synovial cell line MH7A was f...
Source: Biochemical and Biophysical Research communications - March 9, 2016 Category: Biochemistry Authors: Wang H, Dong BW, Zheng ZH, Wu ZB, Li W, Ding J Tags: Biochem Biophys Res Commun Source Type: research

MicroRNA-20a negatively regulates expression of NLRP3-inflammasome by targeting TXNIP in adjuvant-induced arthritis fibroblast-like synoviocytes
Conclusion Taken together, these results indicate that miR-20a may play a pivotal role in the NLRP3-inflammasome by targeted inhibit TXNIP expression in AA FLSs.
Source: Joint Bone Spine - February 29, 2016 Category: Orthopaedics Source Type: research

Methotrexate and its therapeutic antagonists, caffeine and theophylline, target a motogenic T-cell mechanism driven by thrombospondin-1 (TSP-1).
This article is protected by copyright. All rights reserved. PMID: 26909742 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - February 23, 2016 Category: Allergy & Immunology Authors: Talme T, Bergdahl E, Sundqvist KG Tags: Eur J Immunol Source Type: research

GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness.
CONCLUSION: GREM1 is highly expressed in RA joints, and functions as a regulator of survival, proliferation, migration, and invasion of RA-FLS. PMID: 26834210 [PubMed - as supplied by publisher]
Source: J Rheumatol - February 1, 2016 Category: Rheumatology Authors: Han EJ, Yoo SA, Kim GM, Hwang D, Cho CS, You S, Kim WU Tags: J Rheumatol Source Type: research

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts
Conclusions Inhibition of BET family proteins suppresses the inflammatory, matrix-degrading, proliferative and chemoattractive properties of RASF and suggests a therapeutic potential in the targeting of epigenetic reader proteins in RA.
Source: Annals of the Rheumatic Diseases - January 11, 2016 Category: Rheumatology Authors: Klein, K., Kabala, P. A., Grabiec, A. M., Gay, R. E., Kolling, C., Lin, L.-L., Gay, S., Tak, P. P., Prinjha, R. K., Ospelt, C., Reedquist, K. A. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research

Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression
Conclusions Inflammatory cytokines suppress RA FLS HDAC5 expression, promoting nuclear localisation of IRF1 and transcription of a subset of type I interferon response genes. Our results identify HDAC5 as a novel inflammatory mediator in RA, and suggest that strategies rescuing HDAC5 expression in vivo, or the development of HDAC inhibitors not affecting HDAC5 activity, may have therapeutic applications in RA treatment.
Source: Annals of the Rheumatic Diseases - January 11, 2016 Category: Rheumatology Authors: Angiolilli, C., Grabiec, A. M., Ferguson, B. S., Ospelt, C., Malvar Fernandez, B., van Es, I. E., van Baarsen, L. G. M., Gay, S., McKinsey, T. A., Tak, P. P., Baeten, D. L., Reedquist, K. A. Tags: Genetics, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research

Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation
Conclusions These data suggest that MTX therapeutically conditions vascular endothelium via activation of AMPK-CREB. We propose that this mechanism contributes to the protection against cardiovascular events seen in patients with RA treated with MTX.
Source: Annals of the Rheumatic Diseases - January 11, 2016 Category: Rheumatology Authors: Thornton, C. C., Al-Rashed, F., Calay, D., Birdsey, G. M., Bauer, A., Mylroie, H., Morley, B. J., Randi, A. M., Haskard, D. O., Boyle, J. J., Mason, J. C. Tags: Open access, Genetics, Immunology (including allergy), Inflammation, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Basic and translational research Source Type: research

Downstream activation of NF-κB in the EDA-A1/EDAR signalling in Sjögren's syndrome and its regulation by the ubiquitin-editing enzyme A20.
This article is protected by copyright. All rights reserved. PMID: 26724675 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - January 2, 2016 Category: Allergy & Immunology Authors: Sisto M, Barca A, Lofrumento DD, Lisi S Tags: Clin Exp Immunol Source Type: research

Histone methylation and STAT3 differentially regulate IL‐6‐induced MMP gene activation in rheumatoid arthritis synovial fibroblasts
Conclusion. We show that the histone methylation and STAT3 regulate spontaneous and IL‐6‐induced MMPs gene activation in RASFs. The network of the chromatin structure and transcription factors may regulate distinct arthritogenic properties of RASFs. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - December 29, 2015 Category: Rheumatology Authors: Yasuto Araki, Takuma Tsuzuki Wada, Yoshimi Aizaki, Kojiro Sato, Kazuhiro Yokota, Kenta Fujimoto, Yoon‐Taek Kim, Hiromi Oda, Riki Kurokawa, Toshihide Mimura Tags: Full Length Source Type: research

TIGIT overexpression diminishes the function of CD4 T cells and ameliorates the severity of rheumatoid arthritis in mouse models.
In this study, we investigated the role of T cell immunoglobulin and ITIM (immunoreceptor tyrosine-based inhibition motif) domain (TIGIT) in RA. The frequency of TIGIT-positive CD4(+) T cells in the synovial fluid (SF) of active RA patients was lower than that of inactive RA patients. And a negative correlation between RA disease activity and TIGIT expression was found. In CD4(+) T cells isolated from SF of active RA patients, TIGIT upregulation significantly decreased cell proliferation, as shown by MTT assay. TIGIT overexpression also significantly decreased the production of IFN-γ and IL-17, and increased that of IL-10...
Source: Experimental Cell Research - December 9, 2015 Category: Cytology Authors: Zhao W, Dong Y, Wu C, Ma Y, Jin Y, Ji Y Tags: Exp Cell Res Source Type: research

Interleukin-33 acts as a transcriptional repressor and extracellular cytokine in fibroblast-like synoviocytes in patients with rheumatoid arthritis.
Abstract The present study aimed to assess the functions of interleukin (IL)-33 in fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA). Enzyme-linked immunosorbent assays (ELISAs) were used to quantify interleukin (IL)-33 in plasma obtained from patients with RA and osteoarthritis (OA). To evaluate functions of intracellular IL-33, levels of inflammatory mediators and matric metalloproteinases (MMPs) were measured in RA FLS transfected with IL-33 small- interfering RNA (siRNA) or plasmids, and changes in the expression and regulation of nuclear factor kappaB (NF-κB) were determined usi...
Source: Cytokine - October 29, 2015 Category: Molecular Biology Authors: Lee EJ, So MW, Hong S, Kim YG, Yoo B, Lee CK Tags: Cytokine Source Type: research