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Condition: Rheumatoid Arthritis

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Total 292 results found since Jan 2013.

Targeted Combination of Antioxidative and Anti ‐Inflammatory Therapy of Rheumatoid Arthritis using Multifunctional Dendrimer‐Entrapped Gold Nanoparticles as a Platform
A multifunctional dendrimer nanoplatform is developed to have entrapped gold nanoparticles within dendrimer interiors, and covalently linked PEGylated alpha ‐tocopheryl succinate, PEGylated folic acid, and 1,3‐propane sultone on dendrimer peripheries. The designed nanoplatform enables co‐delivery of drug/gene to macrophage cells, effectively scavenging reactive oxygen species and inhibiting tumor necrosis factor‐α expression for combined antiox idative and anti‐inflammatory therapy of rheumatoid arthritis. AbstractAbundant reactive oxygen species and tumor necrosis factor ‐α (TNF‐α) cytokine supply of M1...
Source: Small - November 17, 2020 Category: Nanotechnology Authors: Jin Li, Liang Chen, Xiaoying Xu, Yu Fan, Xue Xue, Mingwu Shen, Xiangyang Shi Tags: Full Paper Source Type: research

Inhibition of Cathepsin K Alleviates Autophagy-Related Inflammation in Periodontitis-Aggravating Arthritis Host Response and Inflammation
Rheumatoid arthritis (RA) and periodontitis share many epidemiological and pathological features, with emerging studies reporting a relationship between the two diseases. Recently, RA and periodontitis have been associated with autophagy. In the present study, we investigated the effects of cathepsin K (CtsK) inhibition on RA with periodontitis in a mouse model and its immunological function affecting autophagy. To topically inhibit CtsK periodontitis with arthritis in the animal model, adeno-associated virus (AAV) transfection was performed in periodontal and knee joint regions. Transfection of small interfering RNA (siRN...
Source: Infection and Immunity - November 16, 2020 Category: Infectious Diseases Authors: Yue, Y., Yin, W., Yang, Q., Ren, J., Tan, L., Wang, J., Liu, J., Lu, Q., Ding, H., Zhan, W., Hao, L., Wang, M. Tags: Host Response and Inflammation Source Type: research

Agrimophol suppresses RANKL-mediated osteoclastogenesis through Blimp1-Bcl6 axis and prevents inflammatory bone loss in mice.
In this study, we found that AGR inhibited RANKL-induced osteoclastogenesis, bone-resorption, F-actin ring formation, and the mRNA expression of osteoclast-associated genes such as CTSK, TRAP, MMP-9, and ATP6v0d2 in vitro. In addition, AGR suppressed RANKL-induced expression of c-Fos and NFATc1. However, AGR treatment did not affect NF-κB activation and MAPKs phosphorylation in RANKL-stimulated BMMs, which implicated that AGR might not influence the initial expression of NFATc1 mediated by NF-κB and MAPKs signaling. Our results further indicated that AGR did not alter phosphorylation levels of GSK3β and the expression o...
Source: International Immunopharmacology - November 13, 2020 Category: Allergy & Immunology Authors: Cao J, Wang S, Wei C, Lin H, Zhang C, Gao Y, Xu Z, Cheng Z, Sun WC, Wang HB Tags: Int Immunopharmacol Source Type: research

Endoplasmic reticulum stress perpetuated toll-like receptor signalling-mediated inflammation in rheumatoid arthritis via X-box-binding protein-1.
CONCLUSIONS: Our findings suggest that ER stress and XBP-1 may function in conjunction with TLRs to drive the inflammation of RASF, and this pathway may serve as a therapeutic target for the disease. PMID: 32896245 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - September 12, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Nanoparticle-facilitated delivery of BAFF-R siRNA for B cell intervention and rheumatoid arthritis therapy.
Abstract The present study was designed to explore the effects of B-cell activating factor receptor (BAFF-R) siRNA encapsulated nanoparticles on collagen-induced arthritis (CIA). BAFF-R siRNA encapsulated nanoparticles (NP-siBAFF-R) were constructed using a double emulsion method and was characterized by dynamic light scattering and transmission electron microscopy. Cellular uptake of nanoparticles was determined using flow cytometry. The CIA mouse model was established and the mice were intravenously injected with nanoparticles. NP-siBAFF-R effectively decreased the expression of BAFF-R in B cells and facilitated...
Source: International Immunopharmacology - August 27, 2020 Category: Allergy & Immunology Authors: Wu H, Su S, Wu Y, Wu Y, Zhang Z, Chen Q Tags: Int Immunopharmacol Source Type: research

Study of Double-Targeting Nanoparticles Loaded With MCL-1 siRNA and Dexamethasone for Adjuvant-induced Arthritis Therapy.
In this study, HA-coated pH-responsive nanoparticles loaded with MCL-1 small interfering RNA (siRNA) and dexamethasone (HNPs/MD) were developed for RA treatment. The HNPs/MD had a mean particle size of 117.07 ± 2.21 nm and zeta potential of 15.53 ± 1.06 mV. The release rates of both MCL-1 siRNA and dexamethasone from the HNPs/MD at pH 4.5 and 6.0 were higher than those at pH 7.4, indicating that the nanoparticles were acid-sensitive. Cytotoxicity assays showed that compared with single drug loaded nanoparticles, the HNPs/MD showed higher cytotoxicity to activated macrophages. The superior therapeutic effect of HNPs/MD wa...
Source: European Journal of Pharmaceutics and Biopharmaceutics - July 14, 2020 Category: Drugs & Pharmacology Authors: Li X, Yu C, Meng X, Hou Y, Cui Y, Zhu T, Li Y, Teng L, Sun F, Li Y Tags: Eur J Pharm Biopharm Source Type: research

Identification of a novel microRNA-141-3p/Forkhead box C1/ β -catenin axis associated with rheumatoid arthritis synovial fibroblast function in vivo and in vitro
Conclusions: FoxC1 and miR-141-3p participate in RA pathogenesis by mediating inflammation and SF proliferation, migration, and invasion and thus could be novel targets for RA therapy as a nonimmunosuppressive approach.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jun Wang, Yin Wang, Hui Zhang, Jun Chang, Ming Lu, Weilu Gao, Wendong Liu, Yetian Li, Li Yin, Xiaohe Wang, Yuejun Wang, Mengru Gao, Zongsheng Yin Tags: Research Paper Source Type: research

Inhibition of BMP3 increases the inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis.
Abstract Rheumatoid arthritis (RA) is a persistent autoimmune disease. Fibroblast-like synoviocytes (FLS) are a key component of invasive pannus and a pathogenetic mechanism in RA. Expression of bone morphogenetic protein 3 (BMP3) mRNA is reportedly decreased in the arthritic synovium. We previously showed that BMP3 expression is significantly downregulated in the synovial tissues of RA patients and models of adjuvant-induced arthritis (AIA). In the present study, we explored the association between BMP3 and FLS migration and secretion of proinflammatory factors in RA. We found that inhibition of BMP3 expression u...
Source: Aging - June 21, 2020 Category: Biomedical Science Authors: Song B, Li X, Xu Q, Yin S, Wu S, Meng X, Huang C, Li J Tags: Aging (Albany NY) Source Type: research

Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D
The complement system plays an important role in the pathogenesis of rheumatoid arthritis (RA). Besides driving lectin pathway (LP) activation, the mannan-binding lectin (MBL)-associated serine proteases (MASPs) also play a key role in regulating the alternative pathway (AP). We evaluated the effects of N-acetylgalactosamine (GalNAc)-conjugated MASP-1 and MASP-2 duplexes in vitro and in mice with and without arthritis to examine whether knockdown of MASP-1 and MASP-2 expression affects the development of arthritis. GalNAc-siRNAs for MASP-1 and MASP-2 demonstrated robust silencing of MASP-1 or MASP-2 at pM concentrations in...
Source: Frontiers in Immunology - February 20, 2020 Category: Allergy & Immunology Source Type: research

Activity of fibroblast-like synoviocytes in rheumatoid arthritis was impaired by dickkopf-1 targeting siRNA.
CONCLUSIONS: By inhibiting DKK-1, we were able to inhibit the proliferation, invasion and pro-inflammatory cytokine secretion of FLSs derived from RA, which was mediated by the ERK or the IRAK-1 signaling pathway. These data indicate the application of DKK-1 silencing could be a potential therapeutic approach to RA. PMID: 32068606 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - February 13, 2020 Category: General Medicine Authors: Liu YY, Wang SY, Li YN, Bian WJ, Zhang LQ, Li YH, Long L, Liu X, Zhang XW, Li ZG Tags: Chin Med J (Engl) Source Type: research

Understanding the immunopathogenesis of autoimmune diseases by animal studies using gene modulation: A comprehensive review
This article will give a new perspective on understanding immunopathogenesis of autoimmune diseases not only in animals but also in human. Emerging approaches to investigate cytokine regulation through gene modulation may be a potential approach for the tailored immunomodulation of some autoimmune diseases near in the future.
Source: Autoimmunity Reviews - February 6, 2020 Category: Allergy & Immunology Source Type: research

Angiotensin II inhibits osteogenic differentiation of isolated synoviocytes by increasing DKK-1 expression.
This study aims to investigate the effect of angiotensin II (Ang II) on osteogenic differentiation of synoviocytes and the underlying mechanism. Ang II was showed to inhibite osteogenic differentiation of synoviocytes, which was mitigated by a Dickkopf-1 (DKK-1) inhibitor. DKK-1 was upregulated by Ang II, which was weakened by the Ang II type 1 receptor (AT1R) blocker, reactive oxygen species (ROS) scavenger, and p38 inhibitor. Ang II increased the levels of AT1R, ROS, and NADPH oxidase (NOX), and the upregulations were mitigated by the AT1R blocker or NOX inhibitor. Furthermore, Ang II activated the p38 pathway, which was...
Source: The International Journal of Biochemistry and Cell Biology - January 30, 2020 Category: Biochemistry Authors: Zhang Y, Ding H, Song Q, Wang Z, Yuan W, Ren Y, Zhao Z, Wang C Tags: Int J Biochem Cell Biol Source Type: research

Understanding the immunopathogenesis of autoimmune diseases by animal studies using gene therapy: A comprehensive review
This article will give a new perspective on understanding immunopathogenesis of autoimmune diseases not only in animals but also in human. Emerging approaches to investigate cytokine regulation through gene therapy may be a potential approach for the tailored immunomodulation of some autoimmune diseases near in the future.
Source: Autoimmunity Reviews - January 7, 2020 Category: Allergy & Immunology Source Type: research

Up-regulation of miR-365 promotes the apoptosis and restrains proliferation of synoviocytes through downregulation of IGF1 and the inactivation of the PI3K/AKT/mTOR pathway in mice with rheumatoid arthritis.
CONCLUSION: Our study presents that up-regulation of miR-365 drives on apoptosis and restrains proliferation of synoviocytes in RA through downregulation of IGF1 and the inhibition of the PI3K/AKT/mTOR pathway. Thus, miR-365 may be a potential candidate for treatment of RA. PMID: 31881377 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - December 23, 2019 Category: Allergy & Immunology Authors: Wang X, Gong S, Pu D, Hu N, Wang Y, Fan P, Zhang J, Lu X Tags: Int Immunopharmacol Source Type: research