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Condition: Rheumatoid Arthritis
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Total 292 results found since Jan 2013.
Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF- α-induced inflammatory activation of synovial fibroblasts
This study identified a novel role of Sulf-2 in TNF-α signaling and the activation of RA synoviocytes, providing the rationale for evaluating the therapeutic targeting of Sulf-2 in preclinical models of RA.PMID:36068294 | DOI:10.1038/s41423-022-00913-x
Source: Cellular and Molecular Immunology - September 6, 2022 Category: Molecular Biology Authors: Ruby J Siegel Anil K Singh Paul M Panipinto Farheen S Shaikh Judy Vinh Sang U Han H Mark Kenney Edward M Schwarz Cynthia S Crowson Sadik A Khuder Basil S Khuder David A Fox Salahuddin Ahmed Source Type: research
E3 Ubiquitin Ligases STUB1 Contributes to the Th17/Treg Imbalance via the Ubiquitination of Aryl Hydrocarbon Receptor in Rheumatoid Arthritis
Clin Exp Immunol. 2022 Aug 9:uxac072. doi: 10.1093/cei/uxac072. Online ahead of print.ABSTRACTSTIP1-homologous U-Box containing protein 1 (STUB1) is involved in the development of immune pathologies and the regulation of T cell. However, the potential role of STUB1 in the pathogenesis of rheumatoid arthritis (RA), especially in the regulation of T cells, remains elusive. Here we show that STUB1 promotes the imbalance of Th17/Treg cells through non-degradative ubiquitination of AHR. Using Western blot and flow cytometry analysis, we observe that the level of STUB1 was increased in RA patients compared with healthy controls....
Source: Clinical and Developmental Immunology - August 9, 2022 Category: Allergy & Immunology Authors: Wen Wang Ting Xiang Yachen Yang Zitao Wang Jianmin Xie Source Type: research
Geniposide restricts angiogenesis in experimentary arthritis via inhibiting Dnmt1-mediated PTEN hypermethylation
In this study, human umbilical vein endothelial cells (HUVEC) and adjuvant arthritis (AA) rat models were performed to research in vitro and in vivo. The results showed that GE treatment significantly reduced synovitis and angiogenesis in AA rats, which may be associated with the increased expression of PTEN with GE treatment. Meanwhile, the hypermethylation of PTEN accompanied by the over-expression of DNA methyltransferases (Dnmts) was demonstrated in TNF-α-induced HUVEC and AA rats. Knockdown of Dnmt1 by Dnmt1- siRNA significantly inhibited the tube formation of HUVEC in vitro. GE significantly restricted the angiogene...
Source: International Immunopharmacology - July 31, 2022 Category: Allergy & Immunology Authors: Yanhong Bu Hong Wu Ran Deng Yan Wang Source Type: research
siRNA-based nanotherapeutics as emerging modalities for immune-mediated diseases: A preliminary review
This study will pave the way for new avenues of research into the diagnosis and treatment of IMDs.PMID:35830711 | DOI:10.1002/cbin.11841
Source: Cell Biology International - July 13, 2022 Category: Cytology Authors: Saman Sargazi Rabia Arshad Reza Ghamari Abbas Rahdar Ali Bakhshi Sonia Fathi Karkan Narges Ajalli Muhammad Bilal Ana M D íez-Pascual Source Type: research
Rheumatoid arthritis fibroblast-like synoviocytes maintain tumor-like biological characteristics through ciRS-7-dependent regulation of miR-7
CONCLUSIONS: The results indicate that the dysregulation of miR-7 in FLS may be involved in the pathological processes of RA and that ciRS-7 induced the suppression of tumor-like biological characters of RA-FLS via modulation of miR-7. These findings help us understand the essential roles of a regulatory interaction between ciRS-7 and miR-7 mediating disease activity of RA, and will facilitate to develop potential intervention target for RA.PMID:35752700 | DOI:10.1007/s11033-022-07666-w
Source: Molecular Biology Reports - June 25, 2022 Category: Molecular Biology Authors: Zuoyu Hu Jingrong Chen Manli Wang Weizhen Weng Ye Chen Yunfeng Pan Source Type: research
BNIP3 mediates the different adaptive responses of fibroblast-like synovial cells to hypoxia in patients with osteoarthritis and rheumatoid arthritis
CONCLUSION: In summary, RA-FLSs maintained intracellular redox balance through mitophagy to promote cell survival under hypoxia. The mitophagy of OA-FLSs was too little to maintain the redox balance of mitochondria, resulting in apoptosis. The difference of mitophagy between OA-FLSs and RA-FLSs under hypoxia is mediated by the level of BNIP3 expression.PMID:35690741 | DOI:10.1186/s10020-022-00490-9
Source: Molecular Medicine - June 11, 2022 Category: Molecular Biology Authors: Ran Deng Yan Wang Yanhong Bu Hong Wu Source Type: research
Total Saponins of Radix Clematis Regulate Fibroblast-Like Synoviocyte Proliferation in Rheumatoid Arthritis via the LncRNA OIP5-AS1/MiR-410-3p/Wnt7b Signaling Pathway
In this study, we examined whether the TSC treatment of RA affects the lncRNA OIP5-AS1/miR-410-3p/Wnt7b pathway.MATERIALS AND METHODS: Freund's complete adjuvant was used to create an adjuvant arthritis (AA) rat model with rat synovial cells being harvested and cultured. The experiment comprises a normal group, model group, TSC optimal-dose group, TSC optimal-dose group + lncRNA OIP5-AS1siRNA group, lncRNA OIP5-AS1 siRNA group, and lncRNA OIP5-AS1 siRNA + NC group. MMT was used to screen the optimal concentration of TSC. The level of lncRNA OIP5-AS1, miR-410-3p, Wnt7b, β-catenin, c-Myc, cyclin D1, GSK-3β, and SFRP4 mRNA ...
Source: Evidence-based Complementary and Alternative Medicine - June 7, 2022 Category: Complementary Medicine Authors: Lingyu Pan Yuan Sun Hui Jiang Yan Chen Yeke Jiang Yanquan Han Yongzhong Wang Source Type: research
