BNIP3 mediates the different adaptive responses of fibroblast-like synovial cells to hypoxia in patients with osteoarthritis and rheumatoid arthritis

CONCLUSION: In summary, RA-FLSs maintained intracellular redox balance through mitophagy to promote cell survival under hypoxia. The mitophagy of OA-FLSs was too little to maintain the redox balance of mitochondria, resulting in apoptosis. The difference of mitophagy between OA-FLSs and RA-FLSs under hypoxia is mediated by the level of BNIP3 expression.PMID:35690741 | DOI:10.1186/s10020-022-00490-9

Source: Molecular Medicine - June 11, 2022 Category: Molecular Biology Authors: Ran Deng Yan Wang Yanhong Bu Hong Wu Source Type: research