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Condition: Rheumatoid Arthritis
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Total 292 results found since Jan 2013.
Systemic delivery of siRNA to the colon using peptide modified PEG-PCL polymer micelles for the treatment of ulcerative colitis
In this study, we investigated the effects of siRNA delivered using MPEG-PCL-CH2R4H2C nanomicelles through intravenous administration to the inflammation site of dextran sulfate sodium-induced colitis mice. The MPEG-PCL-CH2R4H2C micelles had optimum physical properties and high siRNA compaction ability. Moreover, model-siRNA delivered through MPEG-PCL-CH2R4H2C showed higher accumulation in the inflammatory site than that of the naked siRNA. Furthermore, intravenous administration of MPEG-PCL-CH2R4H2C/siRelA micelles, targeting siRelA, a subunit of NF-κB, significantly decreased the shortening of large intestine, clinical ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 29, 2021 Category: Drugs & Pharmacology Authors: Hisako Ibaraki Naruhiro Hatakeyama Naoki Arima Akihiro Takeda Yasuo Seta Takanori Kanazawa Source Type: research
Yi Shen Juan Bi Pill Regulates the Bone Immune Microenvironment via the JAK2/STAT3 Signaling Pathway in Vitro
This study provides a new strategy for regulating the bone immune microenvironment in RA with traditional Chinese medicine.
Source: Frontiers in Pharmacology - December 14, 2021 Category: Drugs & Pharmacology Source Type: research
Notch ‐1 and Notch‐3 Mediate Hypoxia‐Induced Activation of Synovial Fibroblasts in Rheumatoid Arthritis
ConclusionThis study identified a functional link between HIF-1 α, Notch-1, and Notch-3 signaling in regulating activation of RASFs and the processes involved in the pathogenesis of RA.
Source: Arthritis and Rheumatology - August 31, 2021 Category: Rheumatology Authors: Jianhai Chen,
Wenxiang Cheng,
Jian Li,
Yan Wang,
Jingqin Chen,
Xin Shen,
Ailing Su,
Donghao Gan,
Liqing Ke,
Gang Liu,
Jietao Lin,
Liang Li,
Xueling Bai,
Peng Zhang Tags: Original Article Source Type: research
Sinomenine increases adenosine A < sub > 2A < /sub > receptor and inhibits NF- κB to inhibit arthritis in adjuvant-induced-arthritis rats and fibroblast-like synoviocytes through α7nAChR
J Leukoc Biol. 2021 Aug 23. doi: 10.1002/JLB.3MA0121-024RRRR. Online ahead of print.ABSTRACTSinomenine (SIN) is a clinical drug for treating rheumatoid arthritis (RA) in China. Our previous study found SIN inhibited inflammation via alpha7 nicotinic acetylcholine receptor (α7nAChR) in macrophages in vitro. Adenosine receptor A2A has anti-inflammatory and immunosuppressive function. However, the mechanisms of SIN acting on α7nAChR and the effect on adenosine A2A receptor (A2A R) in RA are not clear. In the present study, the effects of SIN on adjuvant-induced-arthritis (AIA) rats in vivo and on fibroblast-like synoviocyte...
Source: Journal of Leukocyte Biology - August 23, 2021 Category: Hematology Authors: Lang Yi Junyu Ke Jiayan Liu Huili Lai Yanjun Lv Chong Peng Yingkun Zhi Qun Du Liang Liu Peixun Wang Hua Zhou Yan Dong Source Type: research
The effects of miR-26b-5p on fibroblast-like synovial cells in rheumatoid arthritis (RA-FLS) via targeting EZH2
CONCLUSION: MiR-26b-5p may affect the biological characteristics of RA-FLS via targeting EZH2, including proliferation, apoptosis, invasion and migration, as well as the secretion of cytokines, thus playing a potential therapeutic role in RA.PMID:34325277 | DOI:10.1016/j.tice.2021.101591
Source: Tissue and Cell - July 29, 2021 Category: Cytology Authors: Pei Hu Zheng-Sen Dong Shuang Zheng Xin Guan Lei Zhang Lin Li Zhen Liu Source Type: research
The low expression of long non-coding RNA Linc00638 contributes to rheumatoid arthritis progression by regulating inflammation and oxidative stress
CONCLUSION: RA patients have low expression levels of Linc00638, which may participate in disease progression by regulating inflammation and oxidative stress.PMID:34308844 | DOI:10.12122/j.issn.1673-4254.2021.07.01
Source: Journal of Southern Medical University - July 26, 2021 Category: Universities & Medical Training Authors: Y Sun J Liu L Xin Q Zhou X Chen X Ding X Zhang Source Type: research
