Filtered By:
Condition: Rheumatoid Arthritis

This page shows you your search results in order of date. This is page number 20.

Order by Relevance | Date

Total 292 results found since Jan 2013.

Dual role of autophagy in stress‐induced cell death in rheumatoid arthritis synovial fibroblasts
ConclusionOur data provides the first evidence of a dual role of autophagy in the regulation of death pathways in RASF. A reduced expression of ALFY and the formation of p62‐positive poly‐ubiquitinated protein aggregates promote cell death in RASF under severe ER stress. © 2013 American College of Rheumatology.
Source: Arthritis and Rheumatism - September 1, 2013 Category: Rheumatology Authors: Masaru Kato, Caroline Ospelt, Renate E Gay, Steffen Gay, Kerstin Klein Tags: Full Length Source Type: research

Role of ADAM17, p38 MAPK, cathepsins, and proteasome pathway in the synthesis and shedding of fractalkine/CX3CL1 in rheumatoid arthritis
Conclusions. Our results provide a novel understanding of the role of ADAM17, p38 MAPK, cathepsins, and proteasome pathway in FKN expression and shedding. Regulating these pathways may suppress FKN‐mediated inflammation and tissue destruction. © 2013 American College of Rheumatology.
Source: Arthritis and Rheumatism - July 29, 2013 Category: Rheumatology Authors: Brian A. Jones, Sharayah Riegsecker, Ayesha Rahman, Maria Beamer, Wissam Aboualaiwi, Sadik A. Khuder, Salahuddin Ahmed Tags: Full Length Source Type: research

PSORS1C1 May Be Involved in Rheumatoid Arthritis.
This study investigated whether PSORS1C1/CDSN was involved in RA. The TagSNPs rs3130983, rs3778638 and rs4959053 in the PSORS1C1/CDSN locus were shown to predict susceptibility to RA in two independent RA cohorts using a TaqMan genotyping assay and Sequenom MassARRAY. The expression of PSORS1C1/CDSN was determined with western blotting and ELISA. Cultured synovial fibroblasts from RA patients (RASF) were treated with anti-PSORS1C1 siRNA. The TaqMan genotyping assay demonstrated significant differences in the rs3130983 and rs4959053 allele frequencies (p=0.002001 and 1.74E-07, respectively) and genotype frequencies (0.01050...
Source: Immunology Letters - June 13, 2013 Category: Allergy & Immunology Authors: Sun H, Xia Y, Wang L, Wang Y, Chang X Tags: Immunol Lett Source Type: research

B cell activating factor-dependent expression of vascular endothelial growth factor in MH7A human synoviocytes stimulated with tumor necrosis factor-α
Abstract Angiogenesis in rheumatoid arthritis (RA) is one of the histological hallmarks, which is mediated by expression of vascular endothelial growth factor (VEGF) in RA synovium. VEGF expression is enhanced by TNF-α, the main pro-inflammatory cytokine in RA. B cell activating factor (BAFF) which plays a role in maturation and maintenance of B cells is also associated with autoimmune RA. Here, we investigated whether BAFF could regulate VEGF expression in TNF-α-stimulated synovium using MH7A synovial cells that are established by transfection with the SV40 T antigen. Changes in hBAFF and hVEGF were measured by...
Source: International Immunopharmacology - May 14, 2013 Category: Allergy & Immunology Authors: Lee GH, Lee J, Lee JW, Choi WS, Moon EY Tags: Int Immunopharmacol Source Type: research

Novel transcriptional regulation of VEGF in inflammatory processes.
This study builds upon our previous results in testing the role of mouse LITAF and STAT6B in the regulation of VEGF-mediated processes. Cells cotransfected with a series of VEGF promoter deletions along with truncated forms of mLITAF and/or mSTAT6B identified a DNA binding site (between -338 and -305 upstream of the transcription site) important in LITAF and/or STAT6B-mediated transcriptional regulation of VEGF. LITAF and STAT6B corresponding protein sites were identified. In addition, siRNA-mediated knockdown of mLITAF and/or mSTAT6B leads to significant reduction in VEGF mRNA levels and inhibits LPS-induced VEGF secretio...
Source: J Cell Mol Med - February 18, 2013 Category: Molecular Biology Authors: Tang X, Yang Y, Yuan H, You J, Burkatovskaya M, Amar S Tags: J Cell Mol Med Source Type: research

Differential regulation of HIF‐mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts.
Abstract Inappropriate osteoclast activity instigates pathological bone loss in rheumatoid arthritis. We have investigated how osteoclasts generate sufficient ATP for the energy‐intensive process of bone resorption in the hypoxic microenvironment associated with this rheumatic condition. We show that in human osteoclasts differentiated from CD14+ monocytes hypoxia (24h, 2% O2) (i) increases ATP production and mitochondrial electron transport chain activity (Alamar Blue, O2 consumption); (ii) increases glycolytic flux (glucose consumption, lactate production) and (iii) increases glutamine consumption. We demonstrate that ...
Source: The Journal of Pathology - January 1, 2013 Category: Pathology Authors: Karl J Morten, Luned Badder, Helen J Knowles Tags: Original Paper Source Type: research

MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-like synoviocytes in rats.
Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by the rheumatoid factor and anti-citrullinated peptide antibody (ACPA) against common autoantigens that are widely expressed within and outside the joints. Many factors participate in the pathogenesis of RA, such as cytokine imbalance, Wnt pathway activation, matrix production, and osteoprotegerin on osteoclasts. Fibroblast-like synoviocytes (FLS) activation has an important role in RA pathogenesis. The methyl-CpG-binding protein (MeCP2) which promoted repressed chromatin structure was selectively detected in synovium of diseased articular ...
Source: Cellular Signalling - November 29, 2012 Category: Cytology Authors: Miao CG, Huang C, Huang Y, Yang YY, He X, Zhang L, Lv XW, Jin Y, Li J Tags: Cell Signal Source Type: research