Transcriptional Regulation of CD4+ T Cell Differentiation in Experimentally Induced Arthritis and Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation of the joint synovium and infiltration by activated inflammatory cells. CD4+ T cells form a large proportion of the inflammatory cells invading the synovial tissue, and are involved in the RA pathologic process. In general, CD4+ T cells differentiate into various T helper cell subsets and acquire the functional properties to respond to specific pathogens, and also mediate some autoimmune disorders such as RA. Because the differentiation of T helper cell subsets is determined by the expression of specific transcription factors in respo...
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: Yuya Kondo, Masahiro Yokosawa, Shunta Kaneko, Kotona Furuyama, Seiji Segawa, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida Tags: Review Source Type: research

Lupus Erythematosus cell
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: Armin Rashidi, Stephen I. Fisher Tags: Clinical Image Source Type: research

Is the T Follicular Regulatory / T Follicular Helper Cell Ratio in Blood a Biomarker for Ectopic Lymphoid Structure Formation in Sj ögren's Syndrome?
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: Gwenny M. Verstappen, Uzma Nakshbandi, Esther Mossel, Erlin A. Haacke, Bert van der Vegt, Arjan Vissink, Hendrika Bootsma, Frans G.M. Kroese Tags: Letter to the Editor Source Type: research

Modulation of inflammatory arthritis by gut microbiota through mucosal inflammation and autoantibody generation
ConclusionsThese data support a model in which intestinal dysbiosis triggers mucosal immune responses that stimulate T and B cells that are key for the development of inflammatory arthritis.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: Widian K. Jubair, Jason D. Hendrickson, Erin L. Severs, Hanna M. Schulz, Sumitra Adhikari, Diana Ir, Jose Pagan, Robert Anthony, Charles E. Robertson, Daniel N. Frank, Nirmal K. Banda, Kristine A. Kuhn Tags: Full Length Source Type: research

Two independent studies show blood follicular T cell subsets allow the stratification of Sj ögren's syndrome patients
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: Valter R Fonseca, Vasco C Rom ão, Ana Agua‐Doce, João Eurico Fonseca, Luis Graca Tags: Reply to Letter to the Editor Source Type: research

Development of a Molecular Signature to Monitor Pharmacodynamic Responses Mediated by In Vivo Administration of Glucocorticoids
Abstract ObjectiveTo develop an objective, readily measurable pharmacodynamic biomarker of glucocorticoid (GC) activity. MethodsGenes modulated by prednisolone were identified from in vitro studies using peripheral blood mononuclear cells from normal healthy volunteers (NHVs). Using the criteria of a>2‐fold change relative to vehicle controls and an adjusted P value cutoff of
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: Yanhua Hu, Julie A. Carman, Deborah Holloway, Selena Kansal, Li Fan, Christine Goldstine, Deborah Lee, John E. Somerville, Robert Latek, Robert Townsend, Alyssa Johnsen, Sean Connolly, Somnath Bandyopadhyay, Nancy Shadick, Michael E. Weinblatt, Richard Fu Tags: Full Length Source Type: research

Common Language Description of the Term Rheumatic and Musculoskeletal Diseases (RMDs) for Use in Communication With the Lay Public, Healthcare Providers, and Other Stakeholders Endorsed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR)
A European League Against Rheumatism–American College of Rheumatology working group consisting of practicing and academic rheumatologists, a rheumatology researcher, and a patient representative created a succinct general statement describing rheumatic and musculoskeletal diseases (RMDs) in adults and children in language that can be used in conversations with the lay public, media, healthcare providers, and other stakeholders. Based on the literature review, several elements were deemed important for inclusion in the description of RMDs. First, RMDs encompass many different diseases that can affect individuals at an...
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: D ésirée Heijde, David I. Daikh, Neil Betteridge, Gerd R. Burmester, Afton L. Hassett, Eric L. Matteson, Ronald Vollenhoven, Sharad Lakhanpal Tags: Special Article Source Type: research

Selective Activation of Tumor Necrosis Factor Receptor II Induces Antiinflammatory Responses and Alleviates Experimental Arthritis
ConclusionOur findings support the use of TNFRII‐selective therapeutics as an effective approach to the treatment of arthritic disease and possibly other inflammatory and autoimmune diseases. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 11, 2018 Category: Rheumatology Authors: Roman Fischer, Marcel Proske, Ma ëlle Duffey, Hubert Stangl, George F. Martinez, Nathalie Peters, Alexandra Kraske, Rainer H. Straub, John R. Bethea, Roland E. Kontermann, Klaus Pfizenmaier Tags: Original Article Source Type: research

Comments on the “2017 Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups”. Points of concern
Abstract We have read with interest the report on the 2017 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups” by Lundberg et al (1,2). These criteria represent an important advance in the classification of adult and juvenile idiopathic inflammatory myositis (IIMs), allowing the classification of IIMs in definite (probability cutoff ≥90%), probable (probability ≥55%), possible (probability ≥50% but
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Santos Casta ñeda, Lorenzo Cavagna, Miguel A. González‐Gay, Tags: Letter to the Editor Source Type: research

An ASAS ‐Positive MRI of the Sacroiliac Joints can also Occur in Healthy Individuals, Runners and Women with Postpartum Back Pain
ConclusionA substantial proportion of healthy individuals without current/past back pain has a positive MRI‐SI according to the ASAS definition. Deep (extensive) BME lesions are exclusively found in axSpA patients.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Janneke de Winter, Manouk de Hooge, Marleen van de Sande, Henri ëtte de Jong, Lonneke van Hoeven, Anoek de Koning, Inger Jorid Berg, Roberta Ramonda, Dominique Baeten, Désirée van der Heijde, Angelique Weel, Robert Landewé Tags: Full Length Source Type: research

Reply to Comments on the “Frequency of Chronic Joint Pain following Chikungunya Infection: A Colombian Cohort Study”, the Brazilian Experience
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Aileen Y. Chang, Liliana Encinales, Jeffrey M. Bethony, Gary L. Simon Tags: Reply to Letter to the Editor Source Type: research

Response to Comments on the “2017 EULAR/ACR Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups”. Points of concern
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Anna Tj ärnlund, Matteo Bottai, Ingrid E. Lundberg Tags: Reply to Letter to the Editor Source Type: research

Comments on the article “Frequency of Chronic Joint Pain following Chikungunya Infection: A Colombian Cohort Study”, the Brazilian Experience
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Roberto Mogami, Mirhelen M. De Abreu, Flavio Sztajnbock, Ana C. B. Koifman, Andr é de A Vieira, Rodrigo S. Torezani, Yêdda de F. B.Chagas, João L. P. Vaz Tags: Letter to the Editor Source Type: research

Allopurinol Dose Escalation and Mortality among Patients with Gout: A National Propensity ‐Matched Cohort Study
ConclusionThis is the largest study of allopurinol's effect on mortality and the first to use a rigorous active‐comparator design. Dose escalation was associated with a small (
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Brian W Coburn, Kaleb Michaud, Debra A Bergman, Ted R Mikuls Tags: Full Length Source Type: research

Female reproductive and hormonal factors and incidence of primary total knee arthroplasty due to osteoarthritis
This study included 22,289 women in the Melbourne Collaborative Cohort Study. Data on age at menarche, pregnancy, parity, years of menstruation, oral contraceptive pill (OCP), menopausal status and hormone replacement therapy (HRT) were collected in 1990‐1994. Incidence of TKA during 2001‐2013 was determined by linking cohort records to the National Joint Replacement Registry. All analyses were adjusted for age, BMI at midlife, change in BMI (early reproductive age to midlife), country of birth, physical activity, smoking, and education. ResultsOver 12.7 years, 1,208 TKAs for osteoarthritis were identified. Ever pregna...
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Sultana Monira Hussain, Yuanyuan Wang, Graham G. Giles, Stephen Graves, Anita E. Wluka, Flavia M. Cicuttini Tags: Full Length Source Type: research

An amino acid motif in HLA ‐DRβ1 distinguishes patients with uveitis in juvenile idiopathic arthritis
ConclusionOur findings highlight a genetically distinct, sexually‐dimorphic feature of JIA‐uveitis compared to non‐uveitis JIA. The association indicates the potential involvement for antigen presentation by HLA‐DRβ1 in the development of uveitis in JIA. This work will advance our progress towards treating and preventing sight‐threatening complications of uveitis in children with JIA.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Anne ‐Mieke J. W. Haasnoot, Marco W. Schilham, Sylvia Kamphuis, Petra C. E. Hissink Muller, Arnd Heiligenhaus, Dirk Foell, Kirsten Minden, Roel A. Ophoff, Timothy R. D. J. Radstake, Anneke I. Den Hollander, Tjitske H. C. M. Reinards, Sanne Hiddingh, Nic Tags: Full Length Source Type: research

Patient perceptions of the Raynaud's Condition Score diary provide insight into its performance in clinical trials of Raynaud's phenomenon
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: John D Pauling, Lesley A Saketkoo, Robyn T Domsic Tags: Letter to the Editor Source Type: research

Reply: Pauling, et  al., Efficacy and Safety of Selexipag in Adults With Raynaud's Phenomenon Secondary to Systemic Sclerosis
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Christopher P. Denton, Ariane L. Herrick Tags: Reply to Letter to the Editor Source Type: research

Chronic active arthritis driven by macrophages without involvement of T cells
ConclusionChronic active arthritis can be driven by macrophages without the involvement of T and B cells in the adaptive immune system.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Cecilia Hagert, Outi Sareila, Tiina Kelkka, Kutty Selva Nandakumar, Mattias Collin, Bingze Xu, Simon Gu érard, Johan Bäcklund, Sirpa Jalkanen, Rikard Holmdahl Tags: Full Length Source Type: research

Dysbiotic subgingival microbial communities in periodontally healthy patients with rheumatoid arthritis
ConclusionsOur data demonstrates that the oral microbiome in RA is enriched for inflammophilic and citrulline producing organisms, which may play a role in the production of autoantigenic citrullinated peptides in RA.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Isabel Lopez ‐Oliva, Akshay D. Paropkari, Shweta Saraswat, Stefan Serban, Zehra Yonel, Praveen Sharma, Paola de Pablo, Karim Raza, Andrew Filer, Iain Chapple, Thomas Dietrich, Melissa M. Grant, Purnima S. Kumar Tags: Full Length Source Type: research

Association Between Marginal Jawbone Loss and Onset of Rheumatoid Arthritis and Relationship to Plasma Levels of RANKL
ConclusionMarginal jawbone loss preceded the clinical onset of RA symptoms, but this was observed only in nonsmokers. Moreover, marginal jawbone loss was significantly greater in RANKL‐positive presymptomatic subjects compared with RANKL‐negative presymptomatic subjects and was highest in presymptomatic subjects positive for both ACPA and RANKL. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Elin Kindstedt, Linda Johansson, Py Palmqvist, Cecilia Koskinen Holm, Heidi Kokkonen, Ingegerd Johansson, Solbritt Rantap ää Dahlqvist, Pernilla Lundberg Tags: Original Article Source Type: research

Chikungunya Arthritis Mechanisms in the Americas
ConclusionThis is one of the largest observational studies involving analysis of the synovial fluid of chikungunya arthritis patients. Synovial fluid analysis revealed no detectable chikungunya virus. This finding suggests that chikungunya virus may cause arthritis through induction of potential host autoimmunity, suggesting a role for immunomodulating agents in the treatment of chikungunya arthritis, or that low‐level viral persistence exists in synovial tissue only and is undetectable in synovial fluid. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Aileen Y. Chang, Karen A. O. Martins, Liliana Encinales, St. Patrick Reid, Marlon Acu ña, Carlos Encinales, Christian B. Matranga, Nelly Pacheco, Carlos Cure, Bhavarth Shukla, Teofilo Ruiz Arteta, Richard Amdur, Lisa H. Cazares, Melissa Gregory, Michael Tags: Original Article Source Type: research

Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD ‐1, TIGIT, and TIM‐3 in Lymphocytes From Patients With Systemic Sclerosis
ConclusionThe altered expression and regulatory capacity of co‐IRs in SSc lymphocytes may contribute to disease pathophysiology by modulating the cytokine‐mediated cross‐talk of immune cells and fibroblasts at sites of inflammation and/or fibrosis. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Michelle Fleury, Anna C. Belkina, Elizabeth A. Proctor, Christopher Zammitti, Robert W. Simms, Douglas A. Lauffenburger, Jennifer E. Snyder ‐Cappione, Robert Lafyatis, Hans Dooms Tags: Original Article Source Type: research

Effects of HLA –B27 on Gut Microbiota in Experimental Spondyloarthritis Implicate an Ecological Model of Dysbiosis
ConclusionThe effects of HLA–B27 on gut microbiota and dysbiosis in SpA are highly dependent on the host genetic background and/or environment, despite convergence of dysregulated immune pathways. These results implicate an ecological model of dysbiosis, with the effects of multiple microbes contributing to the aberrant immune response, rather than a single or small number of microbes driving pathogenesis. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Tejpal Gill, Mark Asquith, Stephen R. Brooks, James T. Rosenbaum, Robert A. Colbert Tags: Original Article Source Type: research

Frequency of Chronic Joint Pain Following Chikungunya Virus Infection
ConclusionThis is the first report to describe the frequency of chikungunya virus–related arthritis in the Americas after a 20‐month follow‐up. The high frequency of chronic disease highlights the need for the development of prevention and treatment methods. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 2, 2018 Category: Rheumatology Authors: Aileen Y. Chang, Liliana Encinales, Alexandra Porras, Nelly Pacheco, St. Patrick Reid, Karen A. O. Martins, Shamila Pacheco, Eyda Bravo, Marianda Navarno, Alejandro Rico Mendoza, Richard Amdur, Priyanka Kamalapathy, Gary S. Firestein, Jeffrey M. Bethony, Tags: Original Article Source Type: research

Antibody Responses to Citrullinated and Noncitrullinated Antigens in the Sputum of Subjects With Rheumatoid Arthritis and Subjects at Risk for Development of Rheumatoid Arthritis
ConclusionThese findings suggest that sputum antibody reactivity to particular citrullinated and noncitrullinated proteins/peptides is specific for RA and for subjects at risk of RA, and the association of these proteins/peptides with NETs may be a key feature of early RA–related autoimmunity in the lung. These results further support the hypothesis that the lung plays a role in early RA–related autoimmunity. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 2, 2018 Category: Rheumatology Authors: M. Kristen Demoruelle, Emily Bowers, Lauren J. Lahey, Jeremy Sokolove, Monica Purmalek, Nickie L. Seto, Michael H. Weisman, Jill M. Norris, Mariana J. Kaplan, V. Michael Holers, William H. Robinson, Kevin D. Deane Tags: Original Article Source Type: research

Features, Treatment, and Outcomes of Macrophage Activation Syndrome in Childhood ‐Onset Systemic Lupus Erythematosus
ConclusionMAS was most likely to develop concomitantly with childhood‐onset SLE diagnosis. The majority of the MAS patients were successfully treated with corticosteroids with no MAS relapses. Although the numbers were small, there was a higher risk of death associated with MAS compared to SLE without MAS. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 2, 2018 Category: Rheumatology Authors: R. Ezequiel Borgia, Maya Gerstein, Deborah M. Levy, Earl D. Silverman, Linda T. Hiraki Tags: Original Article Source Type: research

A CD8 α‐ Subset of CD4+SLAMF7+ Cytotoxic T Cells is Expanded in Patients with IgG4‐Related Disease and Decreases following Glucocorticoid Treatment
ConclusionsA subset of CD8α‐CD4+SLAMF7+ cytotoxic TEM cells is oligoclonally expanded in patients with active IgG4‐RD. This population contracts following glucocorticoid‐induced remission. Further characterization of this cell population may provide prognostic information and targets for therapeutic intervention.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 2, 2018 Category: Rheumatology Authors: Emanuel Della ‐Torre, Emanuele Bozzalla‐Cassione, Clara Sciorati, Eliana Ruggiero, Marco Lanzillotta, Silvia Bonfiglio, Hamid Mattoo, Cory A. Perugino, Enrica Bozzolo, Lucrezia Rovati, Paolo Giorgio Arcidiacono, Gianpaolo Balzano, Dejan Lazarevic, Chi Tags: Full Length Source Type: research

Differential clinical associations of anti ‐nuclear matrix protein‐2 autoantibodies in patients with idiopathic inflammatory myopathies
ConclusionThis study indicated that anti‐NXP‐2 autoantibodies served as a useful marker for disease activity, especially in patients without calcinosis. The differential associations between anti‐NXP‐2 autoantibody levels and disease activity suggested a phenotypic difference between patients with and without calcinosis.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 1, 2018 Category: Rheumatology Authors: Hanbo Yang, Xin Lu, Qinglin Peng, Wei Jiang, Jingli Shi, Yamei Zhang, He Chen, Guochun Wang Tags: Full Length Source Type: research

A Randomized, Double ‐Blind, Parallel‐Group, Placebo‐Controlled, Multiple‐Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis
ConclusionsAMG 557 showed safety and potential efficacy, supporting further evaluation of the clinical efficacy of ICOSL blockade in patients with SLE.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 1, 2018 Category: Rheumatology Authors: Laurence E. Cheng, Zahir Amoura, Benjamin Cheah, Falk Hiepe, Barbara A. Sullivan, Lei Zhou, Gregory E. Arnold, Wayne H. Tsuji, Joan T. Merrill, James B. Chung Tags: Brief Report Source Type: research

Lupus regulator peptide P140 represses B ‐cell differentiation by reducing HLA class II molecule overexpression
ConclusionsOur findings show that P140 down‐regulates HLA class II overexpression in human lupus B cells and that likely via a resulting lack of T cell signaling and activation, it hampers B cells differentiation into autoantibody‐secreting plasma cells. This mechanism likely switches off the downstream events leading to pathogenic autoantibodies secretion, thus explaining the highly promising results obtained in P140/Lupuzor™ ‐based clinical trials.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 1, 2018 Category: Rheumatology Authors: Maud Wilhelm, Fengjuan Wang, Nicolas Schall, Jean ‐François Kleinmann, Michael Faludi, Emil Pablo Nashi, Jean Sibilia, Thierry Martin, Evelyne Schaeffer, Sylviane Muller Tags: Full Length Source Type: research

Inflammation Intensity ‐dependent Expression of Osteoinductive Wnt Proteins is Critical for Ectopic New Bone Formation in Ankylosing Spondylitis
ConclusionsInflammation intensity‐dependent expression of osteoinductive Wnt proteins is a key link between inflammation and ectopic new bone formation in AS. Activation of both canonical Wnt/β‐catenin and noncanonical Wnt/PKCδ pathways is required for inflammation‐induced new bone formation.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 27, 2018 Category: Rheumatology Authors: Xiang Li, Jianru Wang, Zhongping Zhan, Sibei Li, Zhaomin Zheng, Taiping Wang, Kuibo Zhang, Hehai Pan, Zemin Li, Nu Zhang, Hui Liu Tags: Full Length Source Type: research

Utilization and Short ‐Term Outcomes of Primary Total Hip and Knee Arthroplasty in the United States and Canada
This study sought to compare utilization and short‐term outcomes of primary TKA and THA in adjacent regions of Canada and the United States. MethodsThe study was designed as a retrospective cohort study of patients who underwent primary TKA or THA, comparing administrative data from New York and Ontario in 2012–2013. Demographic features of the TKA and THA patients, per capita utilization rates, and short‐term outcomes were compared between the jurisdictions. ResultsA higher percentage of New York hospitals performed TKA compared to Ontario hospitals (75.7% versus 42.1%; P
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Authors: Peter Cram, Bruce E. Landon, John Matelski, Vicki Ling, Therese A. Stukel, J. Michael Paterson, Rajiv Gandhi, Gillian A. Hawker, Bheeshma Ravi Tags: Original Article Source Type: research

Diffuse idiopathic skeletal hyperostosis; on the wrong side?
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Authors: Henk A. Martens, Simone S. Boks Tags: Clinical Image Source Type: research

Subcutaneous Abatacept in Patients With Polyarticular ‐Course Juvenile Idiopathic Arthritis: Results From a Phase III Open‐Label Study
Abstract ObjectiveTo investigate pharmacokinetics, effectiveness, and safety of subcutaneous (SC) abatacept over 24 months (M) in patients with polyarticular‐course juvenile idiopathic arthritis (pJIA). MethodsIn this phase III, open‐label, international, multicenter, single‐arm study, patients with pJIA (cohort 1: 6–17 years; cohort 2: 2–5 years) who failed ≥1 disease‐modifying antirheumatic drug received weight‐tiered SC abatacept weekly: 10–
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Authors: Hermine I Brunner, Nikolay Tzaribachev, Gabriel Vega ‐Cornejo, Ingrid Louw, Alberto Berman, Inmaculada Calvo Penadés, Jordi Antón, Francisco Ávila‐Zapata, Rubén Cuttica, Gerd Horneff, Ivan Foeldvari, Vladimir Keltsev, Daniel J Kingsbury, Diego Osc Tags: Full Length Source Type: research

Lgals9 deficiency attenuates nephritis and arthritis in pristane ‐induced lupus model of BALB/c mice
ConclusionGalectin‐9 is required for the induction and development of lupus nephritis and arthritis in pristane‐induced mice model of SLE. The current investigation provided a new strategy, in which the antagonism of Galectin‐9 is beneficial for the treatment of nephritis and arthritis in SLE by targeting activated macrophages.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Authors: Sonia Zeggar, Katsue S. Watanabe, Sanae Teshigawara, Sumie Hiramatsu, Takayuki Katsuyama, Eri Katsuyama, Haruki Watanabe, Yoshinori Matsumoto, Tomoko Kawabata, Ken ‐ei Sada, Toshiro Niki, Mitsuomi Hirashima, Jun Wada Tags: Full Length Source Type: research

ACR Announcements
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Tags: ACR Announcements Source Type: research

Error in Percent Increased SRI ‐6 Response Rate in Subgroup of Atacicept‐Treated Patients Versus Placebo in the Article by Merrill et al (Arthritis Rheumatol, February 2018)
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Tags: Errata Source Type: research

Error in Description of Enzyme Range Calculations in Footnote of Table 3 in the Article by Rider et al (Arthritis Rheumatol, May 2017)
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Tags: Errata Source Type: research

Clinical Connections
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Tags: Clinical Connections Source Type: research

In This Issue
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Tags: In This Issue Source Type: research

Issue Information
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Tags: Issue Information Source Type: research

Abnormal B Cell Development in Systemic Lupus Erythematosus
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Sarah Karrar, Deborah S. Cunninghame Graham Tags: Review Source Type: research

Reply
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: R. Hal Scofield, Rohan Sharma, Valerie M. Harris Tags: Letters Source Type: research

High Levels of DEK Autoantibodies in Sera of Patients With Polyarticular Juvenile Idiopathic Arthritis and With Early Disease Flares Following Cessation of Anti –Tumor Necrosis Factor Therapy
ConclusionDEK autoantibody levels are higher in patients with polyarticular JIA than in those with oligoarticular JIA, and higher in patients who have disease flares after cessation of anti‐TNF therapy. The C‐terminal 25‐aa fragment is the most immunogenic portion of DEK. These findings are significant with respect to the nature of DEK autoantibodies, their contribution to JIA pathogenesis, and their implications for JIA management. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Nirit Mor ‐Vaknin, Miguel Rivas, Maureen Legendre, Smriti Mohan, Ye Yuanfan, Theresa Mau, Anne Johnson, Bin Huang, Lili Zhao, Yukiko Kimura, Steven J. Spalding, Paula W. Morris, Beth S. Gottlieb, Karen Onel, Judyann C. Olson, Barbara S. Edelheit, Michae Tags: Original Article Source Type: research

Marginal Jawbone Loss Is Associated With the Onset of Rheumatoid Arthritis and Is Related to the Plasma Level of RANKL
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Paola Pablo Tags: Editorial Source Type: research

Vasudhaiva Kutumbakam The World is One Family
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Sharad Lakhanpal Tags: Special Source Type: research

What can our hands tell us about the future of our knees?
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Jamie E. Collins Tags: Editorial Source Type: research

Association of Quantitative and Topographic Assessment of Heberden's Nodes with Knee Osteoarthritis: Data from Osteoarthritis Initiative
ConclusionHN number, their locations, and symmetry were associated with knee OA incidence and progression over 8‐years.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Neil Kumar, Nima Hafezi ‐Nejad, Ali Guermazi, Arya Haj‐Mirzaian, Ida K. Haugen, Frank W.  Roemer, Shadpour Demehri Tags: Brief Report Source Type: research

Clinical evolution of patients with new ‐onset inflammatory back pain: a population‐based cohort study
ConclusionA minority of patients with new‐onset IBP progress to SpA, while many resolve. That IBP often resolves may explain the difference between the prevalence of IBP (3‐6%) and prevalence of SpA (0.5‐1%).This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 22, 2018 Category: Rheumatology Authors: Runsheng Wang, Cynthia S. Crowson, Kerry Wright, Michael M. Ward Tags: Full Length Source Type: research