Disease ‐biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations
In conclusion, different MZ lymphomas display biased immunogenetic signatures indicating distinct antigen exposure histories. The existence of rare public stere otypes raises the intriguing possibility that common, pathogen‐triggered, immune‐mediated mechanisms, may result in diverse B lymphoproliferations due to targeting versatile progenitor B cells and/or operating in particular microenvironments. (Source: The Journal of Pathology)
Source: The Journal of Pathology - November 28, 2018 Category: Pathology Authors: Aliki Xochelli, Vasilis Bikos, Eleftheria Polychronidou, Chrysi Galigalidou, Andreas Agathangelidis, Fr édéric Charlotte, Panagiotis Moschonas, Zadie Davis, Monica Colombo, Maria Roumelioti, Lesley‐Ann Sutton, Patricia Groenen, Michiel van Tags: Brief Definitive Report Source Type: research

High expression of CCR5 in melanoma enhances epithelial ‐to‐mesenchymal transition and metastasis via TGFβ1
AbstractChemokine receptors are highly expressed in various cancers and play crucial roles in tumor progression. However, their expression patterns and functions in melanoma are unclear. The present study aimed to identify the chemokine receptors that play critical roles in melanoma progression and unravel the underlying molecular mechanisms. We found that the C ‐C chemokine receptor 5 (CCR5) was more abundant in melanoma cells than normal cells and was positively associated with tumor malignancy in clinical patients. Animal experiments suggested that CCR5 deficiency in B16/F10 or A375 cells suppressed primary tumor grow...
Source: The Journal of Pathology - November 26, 2018 Category: Pathology Authors: Jie Liu, Caihong Wang, Xuhui Ma, Yang Tian, Chunying Wang, Yan Fu, Yongzhang Luo Tags: Original Paper Source Type: research

Initial and crucial genetic events in intestinal ‐type gastric intramucosal neoplasia
This study revealed somatic mutational landscape and initial mutations of GINs, and we report for the first time thatTP53 mutations precede other mutations in intestinal ‐type GC. Our results also indicate that molecular subtyping based onAPC/TP53 mutations would be a high ‐priority approach for determining and predicting the malignant potential of GIN, including D/IEN. (Source: The Journal of Pathology)
Source: The Journal of Pathology - November 26, 2018 Category: Pathology Authors: Hirofumi Rokutan, Hiroyuki Abe, Hiromi Nakamura, Tetsuo Ushiku, Erika Arakawa, Fumie Hosoda, Shinichi Yachida, Yosuke Tsuji, Mitsuhiro Fujishiro, Kazuhiko Koike, Yasushi Totoki, Masashi Fukayama, Tatsuhiro Shibata Tags: Original Paper Source Type: research

What ’s in a name? Molecular sub‐classification of sarcomas creates fresh challenges
AbstractThis commentary addresses the issue of the classification of sarcomas in the article written by Watson and colleagues published recently in this journal. That article delves into the molecular characterization and distinct phenotypes of some recently described entities (e.g. BCOR ‐rearranged sarcomas, CIC‐fused sarcomas), and describes new groups with common characteristics. This commentary focuses on several questions raised in the article, such as what makes a group of sarcomas become a clinical entity, which should be the main driver of sarcoma classification, how the classification of small round cell sarco...
Source: The Journal of Pathology - November 25, 2018 Category: Pathology Authors: Juan D íaz‐Martín, Michele Biscuola, Jonathan Benoit, David Marcilla, Gema Civantos, Enrique de Álava Tags: Invited Commentary Source Type: research

Macrophage CD40 ‐signaling drives experimental autoimmune encephalomyelitis
In conclusion, the CD40 ‐TRAF6 signaling pathway in MHCII+ cells plays a key role in neuro ‐inflammation and demyelination during EAE. Concomitant with the fact that CD40‐TRAF6 interactions are predominant in macrophages, depletion of myeloid CD40 also reduces neuro‐inflammation. CD40‐TRAF6 interactions thus represent a promising therapeutic target for multiple sclerosis. (Source: The Journal of Pathology)
Source: The Journal of Pathology - November 24, 2018 Category: Pathology Authors: Suzanne A.B.M. Aarts, Tom T.P. Seijkens, Pascal J.H. Kusters, Claudia M. Tiel, Myrthe E. Reiche, Myrthe Toom, Linda Beckers, Cindy P.A.A. Roomen, Menno P.J. Winther, Gijs Kooij, Esther Lutgens Tags: Original Paper Source Type: research

shRNA ‐mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth
AbstractThe overall survival for patients with primary glioblastoma is very poor. Glioblastoma contains a subpopulation of glioma stem cells (GSC) which are responsible for tumour initiation, treatment resistance and recurrence. PPAR α is a transcription factor involved in control of lipid, carbohydrate and amino acid metabolism. We have recently shown that PPARα gene and protein expression is increased in glioblastoma and has independent clinical prognostic significance in multivariate analyses. In this work we report that PP ARα is overexpressed in GSC compared to foetal neural stem cells. To investigate the role of P...
Source: The Journal of Pathology - November 22, 2018 Category: Pathology Authors: HR Haynes, HL Scott, CL Killick ‐Cole, G Shaw, T Brend, KM Hares, J Redondo, KC Kemp, LS Ballesteros, A Herman, O Cordero‐Llana, WG Singleton, F Mills, T Batstone, H Bulstrode, RA Kauppinen, H Wurdak, JB Uney, SC Short, A Wilkins, Tags: Original Paper Source Type: research

LKB1 signaling is activated in CTNNB1 ‐mutated HCC and positively regulates β‐catenin‐dependent CTNNB1‐mutated HCC
ABSTRACTHepatocellular carcinomas (HCCs) are known to be highly heterogenous. Within the extensive histopathological and molecular heterogeneity of HCC, tumors with mutations inCTNNB1, encoding β‐catenin, (CTNNB1‐mutated HCC) constitute a very homogeneous group. We previously characterized a distinctive metabolic and histological phenotype forCTNNB1‐mutated HCC. They were found to be well‐differentiated, almost never steatotic, and often cholestatic, with a microtrabecular or acinar growth pattern. Here, we investigated whether LKB1, which controls energy metabolism, cell polarity, and cell growth, mediates the sp...
Source: The Journal of Pathology - November 22, 2018 Category: Pathology Authors: Sara Charawi, Pierre ‐Alexandre Just, Mathilde Savall, Shirley Abitbol, Massiré Traore, Nolwenn Metzger, Roland Ravinger, Catherine Cavard, Benoit Terris, Christine Perret Tags: Original Paper Source Type: research

A novel age ‐related venous amyloidosis derived from EGF‐containing fibulin‐like extracellular matrix protein 1
AbstractMost intractable tissue degenerative disorders share a common pathogenic condition, so ‐called proteinopathy. Amyloid‐related disorders are the most common proteinopathies and are characterized by amyloid fibril deposits in the brain or other organs. Aging is generally associated with development of these amyloid‐related disorders, but we still do not fully understand how functi onal proteins become pathogenic amyloid deposits during the human aging process. We identified a novel amyloidogenic protein, named epidermal growth factor‐containing fibulin‐like extracellular matrix protein 1 (EFEMP1), in massiv...
Source: The Journal of Pathology - November 22, 2018 Category: Pathology Authors: Masayoshi Tasaki, Mitsuharu Ueda, Yoshinobu Hoshii, Mayumi Mizukami, Sayaka Matsumoto, Makoto Nakamura, Taro Yamashita, Akihiko Ueda, Yohei Misumi, Teruaki Masuda, Yasuteru Inoue, Tessei Torikai, Toshiya Nomura, Yukimoto Tsuda, Kyosuke Kanen Tags: Original Paper Source Type: research

MicroRNA ‐374b induces Endothelial‐to‐mesenchymal transition and early‐lesion formation through the inhibition of MAPK7 signaling
AbstractEndothelial ‐mesenchymal transition occurs during intimal hyperplasia and neointima formation via mechanisms that are incompletely understood. Endothelial MAPK7 signaling is a key mechanosensitive factor that protects against endothelial‐mesenchymal transition, but its signaling activity lost in vessel area s that undergoing pathological remodeling.At sites of vascular remodeling in mice and pigs, endothelial MAPK7 signaling was lost. The TGF β‐induced microRNA‐374b targets MAPK7 and its downstream effectors in endothelial cells and its expression induces endothelial‐mesenchymal transition. Gain‐of‐f...
Source: The Journal of Pathology - November 22, 2018 Category: Pathology Authors: Byambasuren Vanchin, Emma Offringa, Julian Friedrich, Marja G.L. Brinker, Bianca Kiers, Alexandre C. Pereira, Martin C. Harmsen, Jan ‐Renier A.J. Moonen, Guido Krenning Tags: Original Paper Source Type: research

Long non ‐coding RNAs influence the transcriptome in pulmonary arterial hypertension: the role of PAXIP1‐AS1
AbstractIn idiopathic pulmonary arterial hypertension (IPAH), global transcriptional changes induce a smooth muscle cell phenotype characterized by excessive proliferation, migration and apoptosis resistance. Long non ‐coding RNAs (lncRNAs) are key regulators of cellular function. Using a compartment‐specific transcriptional profiling approach, we sought to investigate the link between transcriptional reprogramming by lncRNAs and the maladaptive smooth muscle cell phenotype in IPAH. Transcriptional profiling of small remodelled arteries from 18 IPAH patients and 17 controls revealed global perturbations in metabolic, n...
Source: The Journal of Pathology - November 18, 2018 Category: Pathology Authors: Katharina Jandl, Helene Thekkekara Puthenparampil, Leigh M. Marsh, Julia Hoffmann, Jochen Wilhelm, Christine Veith, Katharina Sinn, Walter Klepetko, Horst Olschewski, Andrea Olschewski, Matthias Brock, Grazyna Kwapiszewska Tags: Original Paper Source Type: research

Issue Information
The Journal of Pathology, Volume 246, Issue 4, Page 391-392, December 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - November 16, 2018 Category: Pathology Tags: Issue Information Source Type: research

Recent advances in breast cancer research impacting clinical diagnostic practice
We present a detailed discussion of this progress, including the advances in understanding of breast tumour classification, for example mixed ductal‐lobular tumours and the spectrum of triple‐negative breast cancer. The latest information on clinical trials and implementation of gene‐based diagnostics, including MammaPrint and Oncotype Dx and others, is synthesized, and emerging targeted therapies as well as the burgeoning immuno‐oncology field, and their relevance in breast cancer, are discussed. (Source: The Journal of Pathology)
Source: The Journal of Pathology - November 14, 2018 Category: Pathology Authors: Amy E McCart Reed, Priyakshi Kalita ‐de Croft, Jamie Kutasovic, Jodi M Saunus, Sunil R Lakhani Tags: Invited Review Source Type: research

Fc ‐binding proteins enhance autoantibody‐induced BP180 depletion in pemphigoid
In this study, monoclonal antibody (mAb) against NC16A in combination with Fc‐binding proteins was found to enhance BP180 depletion. Although mAb against the C‐terminus of BP180 does not show pathogenicityin vivo orin vitro, mAb treatment with Fc ‐binding proteins clearly induced skin fragility in mice and BP180 depletion in keratinocytes. Anti‐BP180 mAbs and Fc‐binding proteins were colocalized in the cytoplasm and at the basement membrane zone. Cell adhesion strengths were decreased in parallel with BP180 amounts. Clinically, bullous pemphigoid patients had higher rheumatoid factor titers than controls. Anti‐...
Source: The Journal of Pathology - November 14, 2018 Category: Pathology Authors: Hiroaki Iwata, Mayumi Kamaguchi, Hideyuki Ujiie, Inkin Ujiie, Ken Natsuga, Wataru Nishie, Hiroshi Shimizu Tags: Original Paper Source Type: research

Identification and validation of DOCK4 as a potential biomarker for risk of bone metastasis development in patients with early breast cancer
In conclusion, high DOCK4 in early breast cancer is significantly associated with aggressive disease and with future bone metastasis and is a potentially useful biomarker for subsequent bone metastasis risk.This article is protected by copyright. All rights reserved. (Source: The Journal of Pathology)
Source: The Journal of Pathology - November 14, 2018 Category: Pathology Authors: Jules A. Westbrook, Steven L. Wood, David A. Cairns, Kathryn McMahon, Renu Gahlaut, Helene Thygesen, Mike Shires, Stephanie Roberts, Helen Marshall, Maria R. Oliva, Mark J. Dunning, Andrew M. Hanby, Peter J. Selby, Valerie Speirs, Georgia Ma Tags: Original Paper Source Type: research

UCP2 ‐dependent improvement of mitochondrial dynamics protects against acute kidney injury
This article is protected by copyright. All rights reserved. (Source: The Journal of Pathology)
Source: The Journal of Pathology - November 14, 2018 Category: Pathology Authors: Nan Qin, Ting Cai, Qingqing Ke, Qi Yuan, Jing Luo, Xiaoming Mao, Lei Jiang, Hongdi Cao, Ping Wen, Ke Zen, Yang Zhou, Junwei Yang Tags: Original Paper Source Type: research