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Condition: Rheumatoid Arthritis

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Total 292 results found since Jan 2013.

Effect of CD95 on inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes.
CONCLUSION: Stimulation of CD95 could promote RA-FLS proliferation and inflammation, and activation of the PI3K/Akt signaling pathway might be the possible mechanism. PMID: 25084560 [PubMed - as supplied by publisher]
Source: Cellular Immunology - July 21, 2014 Category: Allergy & Immunology Authors: Li X, Zhang Z, Peng A, He M, Xu J, Shen S, Zhuang J, Huang X Tags: Cell Immunol Source Type: research

NF‐κB inducing kinase is a key regulator of inflammation‐induced and tumor‐associated angiogenesis
Abstract Angiogenesis is essential during development and in pathological conditions such as chronic inflammation and cancer progression. Inhibition of angiogenesis by targeting vascular endothelial growth factor (VEGF) blocks disease progression, but most patients eventually develop resistance which may result from compensatory signaling pathways. In endothelial cells (EC) expression of the pro‐angiogenic chemokine CXCL12 is regulated by non‐canonical nuclear factor (NF)‐κB signaling. Here, we report that NF‐κB‐inducing kinase (NIK) and subsequent non‐canonical NF‐κB signaling regulates both inflammation...
Source: The Journal of Pathology - July 9, 2014 Category: Pathology Authors: A.R. Noort, K.P.M. van Zoest, E.M. Weijers, P. Koolwijk, C.X. Maracle, D.V. Novack, M.J. Siemerink, R.O. Schlingemann, P.P. Tak, S.W. Tas Tags: Original Article Source Type: research

Inhibition of Spermidine/Spermine N1‐Acetyltransferase Activity: A New Therapeutic Concept in Rheumatoid Arthritis
ConclusionThe use of DA alone or in combination with SAM/l‐methionine might introduce a new therapeutic concept in RA. This is the first therapy that would directly target RASFs and thereby inhibit ongoing joint destruction.
Source: Arthritis and Rheumatism - June 27, 2014 Category: Rheumatology Authors: Michel Neidhart, Emmanuel Karouzakis, Astrid Jüngel, Renate E. Gay, Steffen Gay Tags: Rheumatoid Arthritis Source Type: research

Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro.
Abstract To investigate the potential regulation of sphingosine kinase 1 (SPHK1) on the migration, invasion, and matrix metalloproteinase (MMP) expression in human rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). RA-FLS were transfected control siRNA or SPHK1 siRNA. The migration and invasion of unmanipulated control, control siRNA or SPHK1 siRNA- transfected RA-FLS in vitro were measured by the transwell system. The relative levels of SPHK1, PI3K, and AKT as well as AKT phosphorylation in RA-FLS were determined by Western blot. The levels of MMP-2/9 secreted by RA-FLS were detected by ELISA. Knockdown ...
Source: Molecular Biology Reports - May 10, 2014 Category: Molecular Biology Authors: Yuan H, Yang P, Zhou D, Gao W, Qiu Z, Fang F, Ding S, Xiao W Tags: Mol Biol Rep Source Type: research

Role of cathepsin B in regulating migration and invasion of fibroblast‐like synoviocytes into inflamed tissue from patients with rheumatoid arthritis
Abstract Cathepsin B (CB), an important proteinase that participates in joint destruction in rheumatoid arthritis (RA), exhibits higher expression in fibroblast‐like synoviocyte (FLS) of abnormal proliferative synovial tissues. Whether and how it affects the biological behaviors of RA‐FLS, such as migration and invasion, are poorly understood. In the present study, CB expression in synovial tissues of patients with RA and ostearthritis (OA) were measured by qPCR and immunohistochemistry (IHC), respectively. Stable depletion of endogenous CB was achieved by siRNA transfection, and decrease of CB activity was acquired ...
Source: Clinical and Experimental Immunology - April 22, 2014 Category: Allergy & Immunology Authors: Bei Tong, Bin Wan, Zhifeng Wei, Ting Wang, Peng Zhao, Yannong Dou, Zheng Lv, Yue Dai, Yufeng Xia Tags: Original Article Source Type: research

Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis.
Abstract Cathepsin B (CB), an important proteinase that participates in joint destruction in rheumatoid arthritis (RA), exhibits higher expression in fibroblast-like synoviocyte (FLS) of abnormal proliferative synovial tissues. Whether and how it affects the biological behaviors of RA-FLS, such as migration and invasion, are poorly understood. In the present study, CB expression in synovial tissues of patients with RA and ostearthritis (OA) were measured by qPCR and immunohistochemistry (IHC), respectively. Stable depletion of endogenous CB was achieved by siRNA transfection, and decrease of CB activity was acqu...
Source: Clinical and Developmental Immunology - April 22, 2014 Category: Allergy & Immunology Authors: Tong B, Wan B, Wei Z, Wang T, Zhao P, Dou Y, Lv Z, Dai Y, Xia Y Tags: Clin Exp Immunol Source Type: research

Inhibition of spermidine/spermine N1‐acetyltransferase (SSAT1) activity – a new therapeutical concept in rheumatoid arthritis
Conclusion. The use of DA alone or in combination with SAM / L‐methionine might introduce a new therapeutic concept in RA. This is the first therapy that would directly target RASF and thereby inhibit the ongoing joint destruction. © 2014 American College of Rheumatology.
Source: Arthritis and Rheumatism - February 27, 2014 Category: Rheumatology Authors: Michel Neidhart, Emmanuel Karouzakis, Astrid Jüngel, Renate E. Gay, Steffen Gay Tags: Full Length Source Type: research

Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2
Conclusion: Our results demonstrate that EPCR is overexpressed by RASF and mediates the aggressive behavior of RASF. This function of EPCR is contrary to its cytoprotective role in other settings, and is likely driven by sPLA2V.
Source: Arthritis Research and Therapy - February 5, 2014 Category: Rheumatology Authors: Meilang XueKaitlin ShenKelly McKelveyJuan LiYee-Ka ChanVicky HatzisLyn MarchChristopher LittleMichael TonkinChristopher Jackson Source Type: research

Fucosyltransferase 1 mediates angiogenesis, cell adhesion and rheumatoid arthritis synovial tissue fibroblast proliferation
Conclusions: These data show that alpha(1,2)-linked fucosylated proteins are upregulated in RA ST compared to NL ST. We also show that fut1 in RA synovial fibroblasts is important in angiogenesis, leukocyte-synovial fibroblast adhesion, and synovial fibroblast proliferation, all key processes in the pathogenesis of RA.
Source: Arthritis Research and Therapy - January 28, 2014 Category: Rheumatology Authors: Takeo IsozakiJeffrey RuthMohammad AminPhillip CampbellPei-Suen TsouChristine HaG HainesGautam EdhayanAlisa Koch Source Type: research

CARD11 blockade suppresses murine collagen‐induced arthritis via inhibiting CARD11/Bcl10 assembly and Th17 response
Summary The scaffold protein caspase recruitment domain‐containing protein 11 (CARD11) is implicated in the regulation of inflammation and autoimmunity. The present study aimed to explore the role of CARD11 in the pathogenesis of rheumatoid arthritis (RA). Mice with collagen‐induced arthritis (CIA) were treated with either CARD11‐targeted interfering RNA (CARD11 siRNA) or control siRNA by intraperitoneal injection every 3d after CIA establishment. The clinical score of arthritis was recorded every other day. Synovial inflammation and cartilage erosion were evaluated by histology and micro‐computed tomography (micro...
Source: Clinical and Experimental Immunology - January 21, 2014 Category: Allergy & Immunology Authors: Hongyue Wang, Jijun Zhao, Hui Zhang, Yuefang Huang, Shuang Wang, Qingqiang Tu, Niansheng Yang Tags: Original Article Source Type: research

CARD11 blockade suppresses murine collagen-induced arthritis via inhibiting CARD11/Bcl10 assembly and Th17 response.
Abstract The scaffold protein caspase recruitment domain-containing protein 11 (CARD11) is implicated in the regulation of inflammation and autoimmunity. The present study aimed to explore the role of CARD11 in the pathogenesis of rheumatoid arthritis (RA). Mice with collagen-induced arthritis (CIA) were treated with either CARD11-targeted interfering RNA (CARD11 siRNA) or control siRNA by intraperitoneal injection every 3d after CIA establishment. The clinical score of arthritis was recorded every other day. Synovial inflammation and cartilage erosion were evaluated by histology and micro-computed tomography (mic...
Source: Clinical and Developmental Immunology - January 20, 2014 Category: Allergy & Immunology Authors: Wang H, Zhao J, Zhang H, Huang Y, Wang S, Tu Q, Yang N Tags: Clin Exp Immunol Source Type: research

Role of ADAM‐17, p38 MAPK, Cathepsins, and the Proteasome Pathway in the Synthesis and Shedding of Fractalkine/CX3CL1 in Rheumatoid Arthritis
ConclusionOur results provide new understanding of the role of ADAM‐17, p38 MAPK, cathepsins, and the proteasome pathway in FKN expression and shedding. Regulating these pathways may suppress FKN‐mediated inflammation and tissue destruction.
Source: Arthritis and Rheumatism - October 28, 2013 Category: Rheumatology Authors: Brian A. Jones, Sharayah Riegsecker, Ayesha Rahman, Maria Beamer, Wissam Aboualaiwi, Sadik A. Khuder, Salahuddin Ahmed Tags: Rheumatoid Arthritis Source Type: research

Osteopontin has a crucial role in osteoclast‐like multinucleated giant cell formation
In this study, we hypothesized that OPN is a key factor for generation of OC‐like MGCs from iDCs. We used an in vitro culture system to differentiate iDCs, derived from monocytes obtained from the blood of healthy donors, into OC‐like MGCs. We evaluated OPN levels and expression of OPN receptors during the course of differentiation. OPN has an arginine‐glycine‐aspartic acid (RGD) motif, and protease cleavage reveals a SVVYGLR motif. The concentrations of both full‐length and cleaved forms of OPN increased during the course of OC‐like MGC formation. Expression of OPN RGD‐ and SVVYGLR‐recognizing receptors al...
Source: Journal of Cellular Biochemistry - October 15, 2013 Category: Biochemistry Authors: Yukiko Oh, Iekuni Oh, Junko Morimoto, Toshimitsu Uede, Akira Morimoto Tags: Article Source Type: research

Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes
Conclusions These data suggest that AHR antagonism may represent a viable adjuvant therapeutic strategy for the amelioration of inflammation associated with RA.
Source: Annals of the Rheumatic Diseases - September 4, 2013 Category: Rheumatology Authors: Lahoti, T. S., John, K., Hughes, J. M., Kusnadi, A., Murray, I. A., Krishnegowda, G., Amin, S., Perdew, G. H. Tags: Immunology (including allergy), Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Epidemiology Basic and translational research Source Type: research

Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis
Conclusions Our results show that the expression of NAMPT in Ly6Chigh monocytes promotes many downstream effects involved in inflammatory arthritis and demonstrate the utility of targeting disease-causing genes, such as NAMPT, in Ly6Chigh monocytes for therapeutic intervention in arthritis.
Source: Annals of the Rheumatic Diseases - September 4, 2013 Category: Rheumatology Authors: Presumey, J., Courties, G., Louis-Plence, P., Escriou, V., Scherman, D., Pers, Y.-M., Yssel, H., Pene, J., Kyburz, D., Gay, S., Jorgensen, C., Apparailly, F. Tags: Genetics, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research