Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis

Conclusions Our results show that the expression of NAMPT in Ly6Chigh monocytes promotes many downstream effects involved in inflammatory arthritis and demonstrate the utility of targeting disease-causing genes, such as NAMPT, in Ly6Chigh monocytes for therapeutic intervention in arthritis.

http://ard.bmj.com/cgi/content/short/72/10/1717?rss=1

Source: Annals of the Rheumatic Diseases - September 4, 2013 Category: Rheumatology Authors: Presumey, J., Courties, G., Louis-Plence, P., Escriou, V., Scherman, D., Pers, Y.-M., Yssel, H., Pene, J., Kyburz, D., Gay, S., Jorgensen, C., Apparailly, F. Tags: Genetics, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research