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Condition: Rheumatoid Arthritis
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Total 292 results found since Jan 2013.
Interleukin-13 reduces bone erosion in rheumatoid arthritis by up-regulating osteoprotegerin expression in fibroblast-like synoviocytes : an in vitro and in vivo study
CONCLUSIONS: IL-13 can inhibit osteoclastogenesis by up-regulating OPG in RA-FLSs through IL-13 receptors via the STAT6 pathway, thus may ameliorate bone erosion in RA.PMID:36995338 | DOI:10.55563/clinexprheumatol/b96n1e
Source: Clinical and Experimental Rheumatology - March 30, 2023 Category: Rheumatology Authors: Ziyan Chen Zixue Cheng Zhicheng Tang Mei Li Xiaojun Tang Huayong Zhang Lingyun Sun Source Type: research
BAFF Promotes FLS Activation Through BAFFR-Mediated Non-canonical NF- κB Pathway and the Effects of CP-25
In this study, we aimed to understand the mechanism by which BAFF activates FLS and the effect of CP-25 on FLS function. Therefore, the proliferation and migration abilities of FLS and key proteins on the non-canonical NF- κB pathway were examined. The results showed that compared with the FLS of normal rats/OA patients, the expression of BAFF-R, TRAF2, NIK, p-IKKα, P100, and P52 was higher in the FLS of AA rats/RA patients, while the expression of TRAF3 was lower. And, BAFF promotes FLS activation by activating the non-canonical NF-κB signaling pathway. Meanwhile, BAFFR-siRNA inhibited the proliferation of FLS and the ...
Source: Inflammation - January 16, 2023 Category: Allergy & Immunology Source Type: research
Preparation of Mesoporous Silica Nanocarriers Targeting Glucose-6-Phosphate Isomerase Inhibition and Application in the Treatment of Rheumatoid Arthritis
In conclusion, siG6PI-MSN effectively suppress the proliferation and invasive growth of synovial tissue and improve joint swelling and inflammatory infiltration, thereby preventing joint damage in RA. This carrier may be a new therapeutic measure for RA, with potential social and economic benefits.PMID:36610698 | DOI:10.1093/cei/uxac116
Source: Clinical and Developmental Immunology - January 7, 2023 Category: Allergy & Immunology Authors: Ming Zong Yu Cheng Bei Ye Saige Chen Shanshan Yu Menglei Ding Liu Lu Lieying Fan Source Type: research
Amphiphilic Phosphorus Dendrons Associated with Anti-inflammatory siRNA Reduce Symptoms in Murine Collagen-Induced Arthritis
Biomacromolecules. 2023 Jan 4. doi: 10.1021/acs.biomac.2c01117. Online ahead of print.ABSTRACTSmall interfering RNA (siRNA) holds promise for treating rheumatoid arthritis by inhibiting major cytokines such as tumor necrosis factor-α (TNF-α). We developed original cationic amphiphilic phosphorus dendrons to produce dendriplexes associated with TNF-α siRNA. The dendrons were made of 10 pyrrolidinium end groups and a C17 aliphatic chain. The dendriplexes demonstrated the ability to protect siRNA from nuclease degradation and to promote macrophage uptake. Moreover, they led to potent inhibition of TNF-α expression in the ...
Source: Biomacromolecules - January 4, 2023 Category: Biochemistry Authors: Zhibo Yu Nicolas Tsapis Fran çois Fay Liang Chen Andrii Karpus Xiangyang Shi Catherine Cailleau Samuel Garc ía Pérez Nicolas Huang Juliette Vergnaud Serge Mignani Jean-Pierre Majoral Elias Fattal Source Type: research
Acid sensor ASIC1a induces synovial fibroblast proliferation via Wnt/ β-catenin/c-Myc pathway in rheumatoid arthritis
Int Immunopharmacol. 2022 Oct 21;113(Pt A):109328. doi: 10.1016/j.intimp.2022.109328. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia and progressive joint destruction in the middle and late stages. Notably, activated rheumatoid arthritis synovial fibroblasts (RASFs) exhibit tumor-like features, including an increased proliferation rate that largely contributes to pannus formation and joint destruction. Our previous studies have demonstrated that acid-sensing ion channel 1a (ASIC1a) was highly expressed in RASFs, and acidic microenvironment of sy...
Source: International Immunopharmacology - October 24, 2022 Category: Allergy & Immunology Authors: Yayun Xu Zheng Lu Yian Ling Ruirui Hou Jingjing Tao Ge Deng Xiaoling Xu Xuewei Chen Jingjing Ruan Yihao Zhang Xiaoqing Peng Feihu Chen Source Type: research
Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis
CONCLUSION: CAT-1 is upregulated and promotes FLS proliferation by taking up L-arginine, thereby promoting RA progression.PMID:36253807 | DOI:10.1186/s13075-022-02921-8
Source: Cell Research - October 17, 2022 Category: Cytology Authors: Ying Lu Chongbo Hao Shanshan Yu Zuan Ma Xuelian Fu Mingqing Qin Menglei Ding Zengguang Xu Lieying Fan Source Type: research
GSE214842 ATF6 αis required for the inflammation and survival in rheumatoid arthritis fibroblast-like synoviocytes
Contributors : L Ge ; L Wang ; Y ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo characterize transcriptome changes upon ATF6 α knockdown by the siRNA in rheumatoid arthritis fibroblast-like synoviocytes (RA FLSs)
Source: GEO: Gene Expression Omnibus - October 6, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
