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Condition: Rheumatoid Arthritis
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Total 292 results found since Jan 2013.
CD5L aggravates rheumatoid arthritis progression via promoting synovial fibroblasts proliferation and activity
In conclusion, CD5L promote RA disease progression via activating RASFs. CD5L blocking is a potential therapeutic approach for RA patients.PMID:37191481 | DOI:10.1093/cei/uxad054
Source: Clinical and Developmental Immunology - May 16, 2023 Category: Allergy & Immunology Authors: Xia-Nan Wu Zhao-Wei Gao Lan Yang Juan Zhang Chong Liu Hui-Zhong Zhang Ke Dong Source Type: research
CX-4945 inhibits fibroblast-like synoviocytes functions through the CK2-p53 axis to reduce rheumatoid arthritis disease severity
Int Immunopharmacol. 2023 Apr 13;119:110163. doi: 10.1016/j.intimp.2023.110163. Online ahead of print.ABSTRACTFibroblast-like synoviocytes (FLS) mediate many pathological processes in rheumatoid arthritis (RA), including pannus formation, bone erosion, and inflammation. RA FLS have unique aggressive phenotypes and exhibit several tumor cell-like characteristics, including hyperproliferation, excessive migration and invasion. Casein kinase 2 (CK2) is reportedly overexpressed in numerous tumor types, and targeted inhibition of CK2 has therapeutic benefits for tumors. However, the expression level of CK2 and its functions in ...
Source: International Immunopharmacology - April 15, 2023 Category: Allergy & Immunology Authors: Yanping Luo Yunxuan Lei Xin Guo Dehao Zhu Haiyang Zhang Zizhen Guo Zichong Xu Hanqing Zhao Yebin Xi Xiaochun Peng Lianbo Xiao Zhaojun Wang Xiaoyin Niu Guangjie Chen Source Type: research
Photoacoustic/ultrasound-guided gene silencing: Multifunctional microbubbles for treating adjuvant-induced arthritis
CONCLUSIONS: The theranostic MBs exhibited a TNF-α gene silencing effect under the guidance of CEUS and PAI. The theranostic MBs served as vehicles for delivering siRNA as well as contrast agents for CEUS and PAI.PMID:37012868 | DOI:10.1016/j.intimp.2023.109978
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Chenyang Zhao Rui Zhang Sirui Liu Xuelan Li Desheng Sun Yuxin Jiang Meng Yang Source Type: research
Resveratrol-induced SIRT1 activation inhibits glycolysis-fueled angiogenesis under rheumatoid arthritis conditions independent of HIF-1 α
ConclusionGlycolysis provides additional energy to sustain Rho/ROCK activation in RA subjects, which promotes VEGF-driven angiogenesis and can be inhibited by SIRT1 activation.
Source: Inflammation Research - April 4, 2023 Category: Research Source Type: research
Interleukin-13 reduces bone erosion in rheumatoid arthritis by up-regulating osteoprotegerin expression in fibroblast-like synoviocytes : an in vitro and in vivo study
CONCLUSIONS: IL-13 can inhibit osteoclastogenesis by up-regulating OPG in RA-FLSs through IL-13 receptors via the STAT6 pathway, thus may ameliorate bone erosion in RA.PMID:36995338 | DOI:10.55563/clinexprheumatol/b96n1e
Source: Clinical and Experimental Rheumatology - March 30, 2023 Category: Rheumatology Authors: Ziyan Chen Zixue Cheng Zhicheng Tang Mei Li Xiaojun Tang Huayong Zhang Lingyun Sun Source Type: research
