Systemic lupus erythematosus and hypertension
Publication date: Available online 12 August 2019Source: Autoimmunity ReviewsAuthor(s): Pamela Munguia-Realpozo, Claudia Mendoza-Pinto, Cristina Sierra Benito, Ricardo O. Escarcega, Mario Garcia-Carrasco, Socorro Mendez Martinez, Ivet Etchegaray Morales, Jose Luis Galvez Romero, Alejandro Ruiz-Arguelles, Ricard CerveraAbstractSystemic lupus erythematosus (SLE) is associated with a high burden of cardiovascular disease (CVD), which is in part imputed to classical vascular risk factors such as hypertension. Hypertension is frequent among patients with SLE and studies show it is more prevalent in SLE patients than in people w...
Source: Autoimmunity Reviews - August 12, 2019 Category: Allergy & Immunology Source Type: research

Antimalarial agents diminish while methotrexate, azathioprine and mycophenolic acid increase BAFF levels in systemic lupus erythematosus
Publication date: Available online 10 August 2019Source: Autoimmunity ReviewsAuthor(s): Borja Hernández-Breijo, Alvaro Gomez, Sofia Soukka, Petter Johansson, Ioannis Parodis (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - August 11, 2019 Category: Allergy & Immunology Source Type: research

HIV protease inhibitors and autoimmunity: An odd, but promising idea
Publication date: Available online 9 August 2019Source: Autoimmunity ReviewsAuthor(s): Gaël Galli, Amanda Poissonnier, Jean Philippe Guégan, Manon Charrier, Vanja Sisirak, Estibaliz Lazaro, Marie-Elise Truchetet, Christophe Richez, Patrick Legembre, Patrick Blanco (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - August 11, 2019 Category: Allergy & Immunology Source Type: research

Next-generation Fc receptor–targeting biologics for autoimmune diseases
Publication date: Available online 9 August 2019Source: Autoimmunity ReviewsAuthor(s): Adrian W. Zuercher, Rolf Spirig, Adriana Baz Morelli, Tony Rowe, Fabian KäsermannAbstractIn recent years, there has been a surge in the research and development of novel molecules as potential therapeutic alternatives to traditional treatments (such as intravenous immunoglobulins) for autoimmune disorders. The aim of this review is to describe different drug development strategies and evaluate how various molecules have performed in clinical trials to date. Broadly, three main approaches have been pursued. Recombinant fragment cryst...
Source: Autoimmunity Reviews - August 11, 2019 Category: Allergy & Immunology Source Type: research

Herpesviruses, autoimmunity and epilepsy: Peptide sharing and potential cross-reactivity with human synaptic proteins
Publication date: Available online 9 August 2019Source: Autoimmunity ReviewsAuthor(s): Guglielmo LuccheseAbstractAggregation of immuno-proteomic data reveal that i) herpesviruses and synaptic proteins –in particular Synapsin-1 and Bassoon - share a large number of hexapeptides that also recur in hundreds of epitopes experimentally validated as immunopositive in the human host, and ii) the shared peptides are also spread among human epilepsy-related proteins. The data suggest that cross-reactive processes may be associated with pathogenetic mechanisms in epilepsy, thus suggesting a role of autoimmunity in etiopatholog...
Source: Autoimmunity Reviews - August 11, 2019 Category: Allergy & Immunology Source Type: research

Are oligoclonal bands associated to lower retinal layer thickness at the time of relapsing remitting multiple sclerosis diagnosis? Evidence from an exploratory study
Publication date: Available online 9 August 2019Source: Autoimmunity ReviewsAuthor(s): Emanuele D'Amico, Aurora Zanghì, Clara Grazia Chisari, Francesco Patti, Mario Zappia (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - August 11, 2019 Category: Allergy & Immunology Source Type: research

Macrophages with regulatory functions, a possible new therapeutic perspective in autoimmune diseases
Publication date: Available online 9 August 2019Source: Autoimmunity ReviewsAuthor(s): Paola Di Benedetto, Piero Ruscitti, Zahava Vadasz, Elias Toubi, Roberto GiacomelliAbstractMacrophages are pivotal cells involved in chronic inflammatory and autoimmune diseases. In fact, during these diseases, activated macrophages may play a critical role, promoting the inflammation as well as mediating the damage resolution. This dichotomy is referred to two end-stage phenotypes of macrophages, conventionally known as M1 and M2, playing a pro-inflammatory and anti-inflammatory role, respectively. The M1 macrophages are the mainly subse...
Source: Autoimmunity Reviews - August 11, 2019 Category: Allergy & Immunology Source Type: research

Autoimmune phenomena involving the pituitary gland in children: New developing data about diagnosis and treatment
Publication date: Available online 8 August 2019Source: Autoimmunity ReviewsAuthor(s): Alberto Romano, Donato Rigante, Clelia CipollaAbstractThe contribution of autoimmune phenomena to dysfunction of hypophysis or hypothalamus is far to be unraveled and also the specific pathways of hypophysitis are poorly understood until now, mostly for the pediatric population. Primary hypophysitis is rare in children and often regarded as an autoimmune disorder, following the evidence of lymphoplasmacytic infiltration in the pituitary gland, detection of anti-pituitary antibodies (APA) and anti-hypotalamus antibodies (AHA) by indirect ...
Source: Autoimmunity Reviews - August 9, 2019 Category: Allergy & Immunology Source Type: research

The potential pathogenic role of glucocorticoid receptor polymorphisms in systemic lupus erythematosus and rheumatoid arthritis
Publication date: Available online 8 August 2019Source: Autoimmunity ReviewsAuthor(s): Anna Bazsó, Ágnes Szappanos, Annamária Kövesdi, Rita Rásonyi, Eszter Nagy, Attila Patócs, Gyula Poór, Emese Kiss (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - August 9, 2019 Category: Allergy & Immunology Source Type: research

Monogenic lupus: Dissecting heterogeneity
Publication date: Available online 8 August 2019Source: Autoimmunity ReviewsAuthor(s): Ommar Omarjee, Cécile Picard, Cécile Frachette, Marion Moreews, Frederic Rieux Laucat, Pauline Sprauel, Sebastien Viel, Jean-Christophe Lega, Brigitte Bader-Meunier, Thierry Walzer, Anne-Laure Mathieu, Rolando Cimaz, Alexandre BelotAbstractSystemic lupus erythematosus (SLE) is a severe lifelong multisystem autoimmune disease characterized by the presence of autoantibodies targeting nuclear autoantigens, increased production of type I interferon and B cell abnormalities. Clinical presentation of SLE is extremely heterogeneou...
Source: Autoimmunity Reviews - August 9, 2019 Category: Allergy & Immunology Source Type: research

Pregnancy and multiple sclerosis: Clinical effects across the lifespan
Publication date: Available online 8 August 2019Source: Autoimmunity ReviewsAuthor(s): Ai-Lan Nguyen, Alana Eastaugh, Anneke van der Walt, Vilija G. JokubaitisAbstractMultiple sclerosis (MS) is commonly diagnosed in women of childbearing age. Having a greater understanding of the effects of pregnancy on the course of MS will lead to improved family-planning counselling for women. We found well-established evidence for a protective effect of pregnancy on relapse occurrence in historical cohorts. More recent studies suggest that the protective effect of pregnancy against relapse may be lost in those women with more active di...
Source: Autoimmunity Reviews - August 9, 2019 Category: Allergy & Immunology Source Type: research

Thyroid disorders in patients with myasthenia gravis: A systematic review and meta-analysis
ConclusionsThis systemic review and meta-analysis provides reliable evidence that thyroid disorders are prevalent in MG, especially TGAb positivity, GD, hyperthyroidism, and HT, and MG is associated with increased risk for thyroid autoimmunity. (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - August 9, 2019 Category: Allergy & Immunology Source Type: research

HLA in myasthenia gravis: From superficial correlation to underlying mechanism
Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Huahua Zhong, Chongbo Zhao, Sushan LuoAbstractMyasthenia gravis (MG) is a rare autoimmune disease characterized by muscle weakness and abnormal fatigability. Like many other autoimmune diseases, genetic contribution to MG has been studied where the HLA system appears to play the most vital role. Although many correlations have been revealed in these studies, the underlying mechanism for them is still in the veil. Based on current evidence, we propose two synergetic mechanisms underlying the MG predisposition via HLA. In brief, the first a...
Source: Autoimmunity Reviews - July 17, 2019 Category: Allergy & Immunology Source Type: research

Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications
Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Giuseppe Murdaca, Alessandro Tonacci, Simone Negrini, Monica Greco, Matteo Borro, Francesco Puppo, Sebastiano GangemiAbstractVitamin D plays a key role in in calcium homeostasis and, thus, provides an important support in bone growth by aiding in the mineralization of the collagen matrix. However, vitamin D performs various immunomodulatory, anti-inflammatory, antioxidant and anti-fibrotic actions. Autoimmune diseases result from an aberrant activation of the immune system, whereby the immune response is directed against harmless self-ant...
Source: Autoimmunity Reviews - July 17, 2019 Category: Allergy & Immunology Source Type: research

Undifferentiated connective tissue disease at risk of systemic sclerosis: A weighted score to identify patients who will evolve
Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Antonella Riccardi, Antonella Marcoccia, Alessia Borgia, Tiziana Guastafierro, Francesco Bondanini, Serena Fasano, Rosaria Irace, Valentina Messiniti, Alessandro Sanduzzi, Marialuisa Bocchino, Aldo Ciani, Michele D'Alto, Paola Argiento, Giovanni Maria De Matteis, Alberto Spanò, Gabriele Valentini (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - July 17, 2019 Category: Allergy & Immunology Source Type: research

Prolonged remission in SLE is possible by using reduced doses of prednisone: An observational study from the Lupus-Cruces and Lupus-Bordeaux inception cohorts
Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Guillermo Ruiz-Irastorza, Beatriz Ruiz-Estevez, Estibaliz Lazaro, Ioana Ruiz-Arruza, Pierre Duffau, Miguel Martin-Cascon, Christophe Richez, Amaia Ugarte, Patrick BlancoAbstractObjectiveThe aim of this study is to compare the frequency of remission, according to DORIS definitions, of inception patients from two European SLE cohorts, with a special focus on the differences between the therapeutic schemes of both Units.MethodsInception patients enrolled after 2000 from the longitudinal Cruces Lupus Cohort (CC) and Bordeaux Lupus Cohort (BC)...
Source: Autoimmunity Reviews - July 17, 2019 Category: Allergy & Immunology Source Type: research

Autoimmunity in psychotic disorders. Where we stand, challenges and opportunities
Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Marina Mané-Damas, Carolin Hoffmann, Shenghua Zong, Amanda Tan, Peter C. Molenaar, Mario Losen, Pilar Martinez-MartínezAbstractPsychotic disorders are debilitating mental illnesses associated with abnormalities in various neurotransmitter systems. The development of disease-modifing therapies has been hampered by the mostly unknown etiologies and pathophysiologies.Autoantibodies against several neuronal antigens are responsible for autoimmune encephalitis. These autoantibodies disrupt neurotransmission within the brain, resu...
Source: Autoimmunity Reviews - July 17, 2019 Category: Allergy & Immunology Source Type: research

Uveitis: Autoimmunity… and beyond
ConclusionWe describe one of the largest cohorts of consecutive uveitis patients referred to a department of internal medicine. The high percentage of uveitis associated with underlying (systemic) diseases highlights the need for a multidisciplinary approach, in order to reduce the diagnostic delay. (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - July 17, 2019 Category: Allergy & Immunology Source Type: research

Antiphospholipid syndrome's genetic and epigenetic aspects
Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Annamaria Iuliano, Mauro Galeazzi, Gian Domenico SebastianiAbstractStudies on last genetic and epigenetic predisposition to APS are summarized. It is well known that genetic predisposition is in HLA system (DR4 and DRw53) and that lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) are both associated with the same HLA antigens. Other genes, outside the MHC, give their contribution to the development of this autoimmune syndrome, such as IRF5, STAT4 and those related to inherited thrombophilia - factor V Leiden and G20210A prothr...
Source: Autoimmunity Reviews - July 17, 2019 Category: Allergy & Immunology Source Type: research

The vermiform appendix in Parkinson's disease: At the crossroad of peripheral immunity, the nervous system and the intestinal microbiome
Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Marco Cosentino, Cristoforo Comi, Franca Marino (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - July 17, 2019 Category: Allergy & Immunology Source Type: research

Tracheobronchial involvement of relapsing polychondritis
Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Nina de Montmollin, Daniel Dusser, Christine Lorut, Jérémie Dion, Nathalie Costedoat-Chalumeau, Luc Mouthon, Guillaume Chassagnon, Marie-Pierre Revel, Xavier PuéchalAbstractRecent studies show that relapsing polychondritis patients with tracheobronchial involvement are distinct from others in terms of clinical characteristics, therapeutic management, and disease evolution. Tracheobronchial involvement affects 20 to 50% of patients and may reveal the disease. It should be sought at the time of diagnosis and at each fol...
Source: Autoimmunity Reviews - July 17, 2019 Category: Allergy & Immunology Source Type: research

Characteristics and prognosis of IgG4-related periaortitis/periarteritis: A systematic literature review
CONCLUSION: Most clinical characteristics were similar between the IgG4-related periaortitis/periarteritis and the non-vascular IgG4-related disease groups; however, serum C-reactive protein level elevation was observed only in the former. Although corticosteroid treatment was effective, this disease can be life-threatening secondary to myocardial infarction, aortic dissection, and aneurysmal rupture. Pre-treatment evaluation of stenosis or aneurysms is important for predicting progression of stenosis or aneurysm after corticosteroid treatment. (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - July 17, 2019 Category: Allergy & Immunology Source Type: research

Interstitial lung disease associated with anti-PM-Scl antibody: A single center experience
Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Kamonpun Ussavarungsi, Kenneth Nugent, Alicia K. Gerke, Matthew D. Krasowski, Rebecca S. Tuetken, Petar S. Lenert (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - July 17, 2019 Category: Allergy & Immunology Source Type: research

Adult onset Still's disease and pregnancy
Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Sara De Carolis, Francesco Cianci, Gelsomina Del Sordo, Serafina Garofalo, Cristina Garufi, Antonio Lanzone, Angelo Zoli, Elisa Gremese (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - July 17, 2019 Category: Allergy & Immunology Source Type: research

Editorial Board
Publication date: August 2019Source: Autoimmunity Reviews, Volume 18, Issue 8Author(s): (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - July 17, 2019 Category: Allergy & Immunology Source Type: research

Editorial Board
Publication date: July 2019Source: Autoimmunity Reviews, Volume 18, Issue 7Author(s): (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - June 19, 2019 Category: Allergy & Immunology Source Type: research

Epidermolysis bullosa acquisita: A comprehensive review
Publication date: Available online 7 June 2019Source: Autoimmunity ReviewsAuthor(s): Khalaf Kridin, Diana Kneiber, Eric H. Kowalski, Manuel Valdebran, Kyle T. AmberAbstractEpidermolysis bullosa acquisita is a rare autoimmune blistering disease which results in vesicle and bullae formation on the skin and erosions on the mucous membranes. EBA is mediated by autoantibodies to collagen VII. Clinically, it can present with numerous phenotypes, though the most common are the mechanobullous and inflammatory variants. Patients with mechanobullous EBA develop non-inflammatory bullae and erosions at sites of trauma while patients w...
Source: Autoimmunity Reviews - June 8, 2019 Category: Allergy & Immunology Source Type: research

P2X7 receptor: A potential therapeutic target for autoimmune diseases
Publication date: Available online 7 June 2019Source: Autoimmunity ReviewsAuthor(s): Fan Cao, Li-Qin Hu, Shu-Ran Yao, Yan Hu, De-Guang Wang, Yin-Guang Fan, Gui-Xia Pan, Sha-Sha Tao, Qin Zhang, Hai-Feng Pan, Guo-Cui WuAbstractP2X7 receptor (P2X7R), a distinct ligand-gated ion channel, is a member of purinergic type 2 receptor family with ubiquitous expression in human body. Previous studies have revealed a pivotal role of P2X7R in innate and adaptive immunity. Once activated, it will meditate some vital cascaded responses including the assembly of nucleotide-binding domain (NOD) like receptor protein 3 (NLRP3) inflammasome,...
Source: Autoimmunity Reviews - June 8, 2019 Category: Allergy & Immunology Source Type: research

The protease systems and their pathogenic role in juvenile idiopathic arthritis
Publication date: Available online 8 June 2019Source: Autoimmunity ReviewsAuthor(s): Francesca Margheri, Anna Laurenzana, Teresa Giani, Laura Maggi, Lorenzo Cosmi, Francesco Annunziato, Rolando Cimaz, Mario Del RossoAbstractNumerous proteases produced by synovial cells of arthritic joints, chondrocytes, macrophages and polymorphonuclear cells have been identified as responsible for the joint damage in rheumatoid arthritis. There are few scientific contributions aimed to identify similar mechanisms in the joints of patients with juvenile idiopathic arthritis. Recently, some mechanisms emerged, triggered by the TH17 and TH1/...
Source: Autoimmunity Reviews - June 8, 2019 Category: Allergy & Immunology Source Type: research

An emerging role of neutrophils and NETosis in chronic inflammation and fibrosis in systemic lupus erythematosus (SLE) and ANCA-associated vasculitides (AAV): Implications for the pathogenesis and treatment
Publication date: Available online 8 June 2019Source: Autoimmunity ReviewsAuthor(s): Eleni Frangou, Dimitrios Vassilopoulos, John Boletis, Dimitrios T. BoumpasAbstractNeutrophils derive from hematopoietic stem cells (HSCs) with systemic inflammation driving their activation and differentiation to myeloid progenitors to ensure enhanced myelopoiesis. Epigenetic reprograming and re-education of these HSCs produces neutrophils primed towards elimination of pathogens and increased inflammatory response. Neutrophils -an important component of acute inflammation- are not present in chronic inflammatory tissues leading to the fals...
Source: Autoimmunity Reviews - June 8, 2019 Category: Allergy & Immunology Source Type: research

Recommendations for managing the manifestations of severe and life-threatening mixed cryoglobulinemia syndrome
Publication date: Available online 8 June 2019Source: Autoimmunity ReviewsAuthor(s): Massimo Galli, Giuseppe Monti, Piero Marson, Patrizia Scaini, Maurizio Pietrogrande, Marco Candela, Laura Castelnovo, Paola Faggioli, Paola Novati, Roberta Zani, Maria Teresa Mascia, Francesco Saccardo, Cesare Mazzaro, Piercarlo Sarzi-Puttini, Marco Sebastiani, Luca Quartuccio, Salvatore De VitaAbstractObjectiveSome of the manifestations of mixed cryoglobulinemia syndrome (MCS) can be severe or life-threatening, and should be rapidly contained but, as the therapeutic approaches to such conditions are largely based on anecdotal data, a cons...
Source: Autoimmunity Reviews - June 8, 2019 Category: Allergy & Immunology Source Type: research

Survival of patient with giant cell arteritis: Impact of vision loss and treatment with aspirin
Publication date: Available online 6 June 2019Source: Autoimmunity ReviewsAuthor(s): Gideon Nesher, Vladimir Poltorak, Isam Hindi, Ronit Nesher, Yossi Dror, Hedi Orbach, Gabriel S. Breuer (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - June 8, 2019 Category: Allergy & Immunology Source Type: research

Seasonal variation in systemic lupus erythematosus and rheumatoid arthritis: An ecological study based on internet searches
Publication date: Available online 6 June 2019Source: Autoimmunity ReviewsAuthor(s): Hai-Feng Pan, Peng Wang, Guo-Cui Wu, Yan-Feng Zou, Zhiwei Xu, Dong-Qing Ye, Wenbiao Hu (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - June 8, 2019 Category: Allergy & Immunology Source Type: research

Rheumatic immune related adverse events in patients treated with checkpoint inhibitors for immunotherapy of cancer
Publication date: Available online 7 June 2019Source: Autoimmunity ReviewsAuthor(s): Gian Domenico Sebastiani, Chiara Scirocco, Mauro GaleazziAbstractImmune checkpoints are small molecules expressed by immune cells that play critical roles in maintaining immune homeostasis. Immune checkpoint inhibitors (ICPIs) are new cancer drugs that target self-tolerance pathways exploited by tumors to escape immune destruction, such a such as cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death 1 (PD-1) or its ligand (PD-L1). Several ICPIs have been approved by Food and Drug Administration, increasing overall survival wi...
Source: Autoimmunity Reviews - June 8, 2019 Category: Allergy & Immunology Source Type: research

MicroRNAs in juvenile idiopathic arthritis: Can we learn more about pathophysiological mechanisms?
Publication date: Available online 7 June 2019Source: Autoimmunity ReviewsAuthor(s): Nadege Nziza, Isabelle Duroux-Richard, Florence ApparaillyAbstractJuvenile idiopathic arthritis (JIA) is a heterogeneous and multifactorial group of chronic arthritis with an onset before the age of 16 years. The pathogenesis of this disease is poorly understood, which makes the distinction among subtypes unclear, delays diagnosis and optimal therapeutic management. MicroRNAs (miRNAs) are small non-coding RNAs that play a critical role in the regulation of immune responses. Their expression is tightly controlled to ensure cellular homeos...
Source: Autoimmunity Reviews - June 8, 2019 Category: Allergy & Immunology Source Type: research

Chronic epipharyngitis: A missing background of IgA nephropathy
Publication date: Available online 7 June 2019Source: Autoimmunity ReviewsAuthor(s): Osamu Hotta, Ayaki Tanaka, Takashi Oda (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - June 8, 2019 Category: Allergy & Immunology Source Type: research

Distal ischemia as the initial presentation of hypereosinophilic syndrome-related arterial involvement: A case study and literature review
Publication date: Available online 7 June 2019Source: Autoimmunity ReviewsAuthor(s): Julien Rohmer, Matthieu Groh, Maxime Samson, Jonathan London, Marie Jachiet, Diane Rouzaud, Romain Paule, Felipe Suarez, Guillaume Lefèvre, Fleur Cohen, Olivier Lambotte, Antoinette Perla, Philip Bielefeld, Loïc Guillevin, Jean-Emmanuel Kahn, Benjamin Terrier, on behalf of the French Vasculitis Study Group (FVSG) (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - June 8, 2019 Category: Allergy & Immunology Source Type: research

The gut microbiota perspective for interventions in MS
Publication date: Available online 7 June 2019Source: Autoimmunity ReviewsAuthor(s): Magdalena ZoledziewskaAbstractThe heritable genetic variation that explains phenotypic differences in a population fluctuates for different autoimmune disorders. Particularly in multiple sclerosis (MS) etiology, modest genetic and major environmental effects emerge.Increasingly recognized as a major environmentally shaped contributor to disease and treatment outcomes are gut microbiota.As discussed here, the observed impact of gut microbiome on MS pathophysiology, involves both quantitative and functional changes in composition, metabolism...
Source: Autoimmunity Reviews - June 8, 2019 Category: Allergy & Immunology Source Type: research

Editorial Board
Publication date: June 2019Source: Autoimmunity Reviews, Volume 18, Issue 6Author(s): (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - May 11, 2019 Category: Allergy & Immunology Source Type: research

Anti-OJ autoantibodies: Rare or underdetected?
Publication date: Available online 3 May 2019Source: Autoimmunity ReviewsAuthor(s): Jean-Baptiste Vulsteke, Minoru Satoh, Kishore Malyavantham, Xavier Bossuyt, Ellen De Langhe, Michael MahlerAbstractAnti-OJ autoantibodies are rare myositis-specific autoantibodies that have been described to target isoleucyl-tRNA synthetase. Routinely used multiplex assays perform poorly in detection of anti-OJ antibodies. In this manuscript, we review the existing literature on critical issues in detection of anti-OJ and the clinical features associated with anti-OJ. The challenging detection with line/blot immunoassays and ELISAs is most ...
Source: Autoimmunity Reviews - May 4, 2019 Category: Allergy & Immunology Source Type: research

Polyphenols in the treatment of autoimmune diseases
Publication date: Available online 3 May 2019Source: Autoimmunity ReviewsAuthor(s): Haroon Khan, Antoni Sureda, Tarun Belwal, Sümeyra Çetinkaya, İpek Süntar, Silvia Tejada, Hari Prasad Devkota, Hammad Ullah, Michael AschnerAbstractIn addition to protecting body from infections and diseases, the immune system produces auto-antibodies that can cause complex autoimmune disorders, such as Type I diabetes, primary biliary cirrhosis, rheumatoid arthritis, and multiple sclerosis, to name a few. In such cases, the immune system fails to recognize between foreign agents and its own body cells. Different factors, s...
Source: Autoimmunity Reviews - May 4, 2019 Category: Allergy & Immunology Source Type: research

Rheumatoid arthritis (RA) and cardiovascular disease
Publication date: Available online 3 May 2019Source: Autoimmunity ReviewsAuthor(s): Arnon Blum, Mohammad AdawiAbstractPatients with rheumatoid arthritis (RA) suffer cardiovascular events 1.5-2 fold than the general population, and cardiovascular (CV) events are leading cause of death in patients with RA. It is known that patients with RA have endothelial dysfunction, related with impaired function of endothelial progenitor cells (EPCs). The mechanistic pathways leading to endothelial function are complicated, but understanding these mechanisms may open new frontiers of management and therapies to patients suffering from at...
Source: Autoimmunity Reviews - May 4, 2019 Category: Allergy & Immunology Source Type: research

Challenges in the treatment of Rheumatoid Arthritis
Publication date: Available online 3 May 2019Source: Autoimmunity ReviewsAuthor(s): Paola Conigliaro, Paola Triggianese, Erica De Martino, Maria Sole Chimenti, Flavia Sunzini, Alessandra Viola, Claudia Canofari, Roberto PerriconeAbstractRheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by a heterogeneous clinical response to the different treatments. Some patients are difficult to treat and do not reach the treatment targets as clinical remission or low disease activity. Known negative prognostic factors, such as the presence of auto-antiantibodies and joint erosion, the presence of a genetic profil...
Source: Autoimmunity Reviews - May 4, 2019 Category: Allergy & Immunology Source Type: research

Placing CD20-targeted B cell depletion in multiple sclerosis therapeutic scenario: Present and future perspectives
Publication date: Available online 3 May 2019Source: Autoimmunity ReviewsAuthor(s): Emanuele D'Amico, Aurora Zanghì, Matteo Gastaldi, Francesco Patti, Diego FranciottaAbstractMultiple sclerosis (MS) is an acquired demyelinating disease of the central nervous system (CNS) that traditionally has been considered to be mediated primarily by T cells. Increasing evidence, however, suggests the fundamental role of B cells in the pathogenesis and development of the disease. Recently, anti-CD20 B cell-based therapies have demonstrated impressive and somewhat surprising results in MS, showing profound anti-inflammatory effect...
Source: Autoimmunity Reviews - May 4, 2019 Category: Allergy & Immunology Source Type: research

Large-vessel vasculitis diagnosed between 50 and 60 years: Case-control study based on 183 cases and 183 controls aged over 60 years
ConclusionLVV onset between 50 and 60 years identifies a subset of patients with more frequent aorta and peripheral vascular involvement and more refractory disease compared to patients with LVV onset after 60. (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - May 4, 2019 Category: Allergy & Immunology Source Type: research

Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system
We present epidemiological, clinical and experimental evidence that ME/CFS constitutes a major type of adverse effect of vaccines, especially those containing poorly degradable particulate aluminum adjuvants. Evidence has emerged very slowly due to the multiplicity, lack of specificity, delayed onset, and frequent medical underestimation of ME/CFS symptoms. It was supported by an epidemiological study comparing vaccinated vs unvaccinated militaries that remained undeployed during Gulf War II. Affected patients suffer from cognitive dysfunction affecting attention, memory and inter-hemispheric connexions, well correlated to...
Source: Autoimmunity Reviews - May 4, 2019 Category: Allergy & Immunology Source Type: research

Differential modulation of CXCL8 versus CXCL10, by cytokines, PPAR-gamma, or PPAR-alpha agonists, in primary cells from Graves' disease and ophthalmopathy
This study investigates the modulation of the secretion of CXCL8 vs. CXCL10, in human primary cells cultures of thyroid follicular cells (TFC) in Graves' disease (GD), and fibroblasts (OF) or preadipocytes (OP) from Graves' ophthalmopathy (GO).MethodsCells were initially incubated with different concentrations of tumor necrosis factor (TNF)α (1, 5, 10 ng/mL). Then, CXCL8 and CXCL10 were measured in the supernatants of TFC, OF or OP cells basally and after 24 h of treatment with interferon (IFN)γ (1000 IU/mL) and/or TNFα (10 ng/mL), in presence/absence of the peroxisome proliferator-activated recep...
Source: Autoimmunity Reviews - May 4, 2019 Category: Allergy & Immunology Source Type: research

Aberrant expression of alternative splicing variants in multiple sclerosis – A systematic review
ConclusionsAn altered RNA processing of genes mediating immune signaling pathways has been repeatedly implicated in MS. The analysis of individual exon-level expression patterns is stimulated by the advancement of transcriptome profiling technologies. In particular, the examination of genes encoded in MS-associated genetic regions may provide important insights into the pathogenesis of the disease and help to identify new biomarkers. (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - May 4, 2019 Category: Allergy & Immunology Source Type: research

Lethal immunoglobulins: Autoantibodies and sudden cardiac death, Autoimmun Rev. 2019 Feb 14. pii: S1568-9972(19)30037-0. doi: 10.1016/j.autrev.2018.12.005. [Epub ahead of print] of Ryabkova VA et al.
Publication date: Available online 4 May 2019Source: Autoimmunity ReviewsAuthor(s): Gerd Wallukat, Ingolf Schimke (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - May 4, 2019 Category: Allergy & Immunology Source Type: research

The burden of chronic kidney disease in systemic lupus erythematosus: A nationwide epidemiologic study
Publication date: Available online 4 May 2019Source: Autoimmunity ReviewsAuthor(s): Arthur Mageau, Jean-François Timsit, Anne Perrozziello, Stéphane Ruckly, Claire Dupuis, Lila Bouadma, Thomas Papo, Karim SacreAbstractObjectiveTo analyze the impact of chronic kidney disease (CKD) on major clinical outcome in SLE by using a nationwide database.Patients and methodsCharacteristics of all admitted SLE patients experiencing CKD (eGFR
Source: Autoimmunity Reviews - May 4, 2019 Category: Allergy & Immunology Source Type: research