Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression

Conclusions
Inflammatory cytokines suppress RA FLS HDAC5 expression, promoting nuclear localisation of IRF1 and transcription of a subset of type I interferon response genes. Our results identify HDAC5 as a novel inflammatory mediator in RA, and suggest that strategies rescuing HDAC5 expression in vivo, or the development of HDAC inhibitors not affecting HDAC5 activity, may have therapeutic applications in RA treatment.

Source: Annals of the Rheumatic Diseases - January 11, 2016 Category: Rheumatology Authors: Angiolilli, C., Grabiec, A. M., Ferguson, B. S., Ospelt, C., Malvar Fernandez, B., van Es, I. E., van Baarsen, L. G. M., Gay, S., McKinsey, T. A., Tak, P. P., Baeten, D. L., Reedquist, K. A. Tags: Genetics, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research