Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation

Conclusions
These data suggest that MTX therapeutically conditions vascular endothelium via activation of AMPK-CREB. We propose that this mechanism contributes to the protection against cardiovascular events seen in patients with RA treated with MTX.

Source: Annals of the Rheumatic Diseases - January 11, 2016 Category: Rheumatology Authors: Thornton, C. C., Al-Rashed, F., Calay, D., Birdsey, G. M., Bauer, A., Mylroie, H., Morley, B. J., Randi, A. M., Haskard, D. O., Boyle, J. J., Mason, J. C. Tags: Open access, Genetics, Immunology (including allergy), Inflammation, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Basic and translational research Source Type: research