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Condition: Obesity

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Total 449 results found since Jan 2013.

Knock-down Sox5 suppresses porcine adipogenesis through BMP R-Smads signal pathway.
In conclusion, our findings uncovered a function of Sox5 in porcine adipogenesis and reveal an interaction between Sox5 and BMP signaling. PMID: 32423805 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - May 14, 2020 Category: Biochemistry Authors: Peng Y, Shi XE, Huang KL, Yao XP, Chen FF, Li X, Yang GS Tags: Biochem Biophys Res Commun Source Type: research

Slc43a3 is a regulator of free fatty acid flux Research Articles
Adipocytes take up long chain FAs through diffusion and protein-mediated transport, whereas FA efflux is considered to occur by diffusion. To identify potential membrane proteins that are involved in regulating FA flux in adipocytes, the expression levels of 55 membrane transporters without known function were screened in subcutaneous adipose samples from obese patients before and after bariatric surgery using branched DNA methodology. Among the 33 solute carrier (SLC) transporter family members screened, the expression of 14 members showed significant changes before and after bariatric surgery. One of them, Slc43a3, incre...
Source: The Journal of Lipid Research - April 30, 2020 Category: Lipidology Authors: Hasbargen, K. B., Shen, W.-J., Zhang, Y., Hou, X., Wang, W., Shuo, Q., Bernlohr, D. A., Azhar, S., Kraemer, F. B. Tags: Research Articles Source Type: research

Mechanisms of impaired pancreatic β‑cell function in high‑fat diet‑induced obese mice: The role of endoplasmic reticulum stress.
Authors: Yi X, Cai X, Wang S, Xiao Y Abstract The aim of the study was to examine whether there was excessive endoplasmic reticulum stress (ERs) in the islets of high‑fat diet (HFD)‑induced obese mice, as well as the effects of ERs on β‑cell function. Male C57BL/6J mice were fed a HFD for 16 weeks. Pancreatic β‑cell function was evaluated using intraperitoneal glucose tolerance and insulin release tests, and via electron microscopy. The expression of activating transcription factor 6 (ATF6) and phosphorylated (p)‑eukaryotic initiation factor 2α (eIF2α) were detected via immunofluorescence staining to...
Source: Molecular Medicine Reports - April 25, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1 Metabolism
Accumulating evidence suggests that brown adipose tissue (BAT) is a potential therapeutic target for managing obesity and related diseases. PGAM family member 5, mitochondrial serine/threonine protein phosphatase (PGAM5), is a protein phosphatase that resides in the mitochondria and regulates many biological processes, including cell death, mitophagy, and immune responses. Because BAT is a mitochondria-rich tissue, we have hypothesized that PGAM5 has a physiological function in BAT. We previously reported that PGAM5-knockout (KO) mice are resistant to severe metabolic stress. Importantly, lipid accumulation is suppressed i...
Source: Journal of Biological Chemistry - April 23, 2020 Category: Chemistry Authors: Sho Sugawara, Yusuke Kanamaru, Shiori Sekine, Lila Maekawa, Akinori Takahashi, Tadashi Yamamoto, Kengo Watanabe, Takao Fujisawa, Kazuki Hattori, Hidenori Ichijo Tags: Cell Biology Source Type: research

Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure
We previously established that global deletion of the enhancer of trithorax and polycomb (ETP) gene, Asxl2, prevents weight gain. Because proinflammatory macrophages recruited to adipose tissue are central to the metabolic complications of obesity, we explored the role of ASXL2 in myeloid lineage cells. Unexpectedly, mice without Asxl2 only in myeloid cells (Asxl2ΔLysM) were completely resistant to diet-induced weight gain and metabolically normal despite increased food intake, comparable activity, and equivalent fecal fat. Asxl2ΔLysM mice resisted HFD-induced adipose tissue macrophage infiltration and inflammatory cytok...
Source: Journal of Clinical Investigation - April 21, 2020 Category: Biomedical Science Authors: Wei Zou, Nidhi Rohatgi, Jonathan R. Brestoff, John R. Moley, Yongjia Li, Jesse W. Williams, Yael Alippe, Hua Pan, Terri A. Pietka, Gabriel Mbalaviele, Elizabeth P. Newberry, Nicholas O. Davidson, Anwesha Dey, Kooresh I. Shoghi, Richard D. Head, Samuel A. Source Type: research

Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1 α pathway in skeletal muscle.
In this study, we found that FGF19 can increase the mRNA and protein expression levels of mitochondrial biogenesis regulators (PGC-1α, Nrf-1, and TFAM) and antioxidant response regulators (Nrf-2 and HO-1), alleviating PA-induced mitochondrial dysfunction and oxidative stress. However, the regulatory effect of FGF19 was blocked by Compound C, an AMP-activated protein kinase (AMPK) inhibitor, and siRNA knockdown of PGC-1a. Taken together, these findings indicate that FGF19 might promote mitochondrial biogenesis and antioxidant response via the AMPK/PGC-1α pathway, attenuating the effect of PA on mitochondrial dysfunction a...
Source: Biochemical and Biophysical Research communications - April 15, 2020 Category: Biochemistry Authors: Guo A, Li K, Xiao Q Tags: Biochem Biophys Res Commun Source Type: research

Role of vaspin in porcine ovary: effect on signaling pathways and steroid synthesis via GRP78 receptor and protein kinase A.
Abstract Vaspin, visceral adipose tissue-derived serine protease inhibitor, is involved in the development of obesity, insulin resistance, inflammation and energy metabolism. Our previous study showed vaspin expression and its regulation in the ovary; however, the role of this adipokine in ovarian cells has never been studied. Here, we studied in vitro the effect of vaspin on various kinase signaling pathways: mitogen-activated kinase (MAP3/1), serine/threonine kinase (AKT), signal transducer and activator of transcription 3 (STAT3) protein kinase AMP (PRKAA1), protein kinase A (PKA) and on expression of nuclear f...
Source: Biology of Reproduction - March 8, 2020 Category: Reproduction Medicine Authors: Kurowska P, Mlyczyńska E, Dawid M, Dupont J, Rak A Tags: Biol Reprod Source Type: research

Taraxacum officinale Wigg. Attenuates Inflammatory Responses in Murine Microglia through the Nrf2/HO-1 and NF- κB Signaling Pathways.
In this study, we evaluated the anti-inflammatory effects of ethanol extracts of T. officinale (A-TOW) by examining the suppression of proinflammatory mediators in LPS-stimulated BV2 and mouse hippocampus. Furthermore, A-TOW also inhibited the nuclear translocation of nuclear factor κB p65 caused by stimulation with LPS. In addition, A-TOW regulates heme oxygenase (HO)-1 expression through the nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) in BV2 cells. The effects of A-TOW on the over-expression of proinflammatory mediators were partially reversed by transfection of the cells with HO-1 siRNA. These fi...
Source: The American Journal of Chinese Medicine - March 4, 2020 Category: Complementary Medicine Authors: Dong L, Dongzhi Z, Jin Y, Kim YC, Lee DS, Huang S, Panichayupakaranant P, Li B Tags: Am J Chin Med Source Type: research

Adipose TBX1 Regulates β-Adrenergic Sensitivity in Subcutaneous Adipose Tissue and Thermogenic Capacity In Vivo
Conclusions: Adipose expression of TBX1 is necessary, but not sufficient, to defend body temperature during cold via proper UCP1 expression. Adipose TBX1 expression was also required for proper insulin signaling in subcutaneous adipose as well as maintaining β-adrenergic sensitivity but overexpression of TBX1 was not sufficient to induce adipocyte beiging or prevent diet induced obesity. TBX1 expression is enriched in adipose stem cells in which it has contrasting effects on adipogenesis in mouse versus human cells. Collectively, these data demonstrate the importance of adipose TBX1 in the regulation of beige adipocyte fu...
Source: Molecular Metabolism - February 19, 2020 Category: Endocrinology Source Type: research

Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation
Conclusions/interpretationThese findings functionally suggest a novel link between obesity and beta cell dysfunction via ROIT. Elucidating a precise mechanism for the effect of obesity on lncRNA expression will broaden our understanding of the pathophysiological development of diabetes and facilitate the design of better tools for diabetes prevention and treatment.Data availabilityThe raw RNA sequencing data are available from the NCBI Gene Expression Omnibus (GEO series accession number GSE139991).
Source: Diabetologia - January 31, 2020 Category: Endocrinology Source Type: research

Interleukin-27 decreases ghrelin production through signal transducer and activator of transcription 3—mechanistic target of rapamycin signaling
In conclusion, IL-27 suppresses ghrelin production through the STAT3-mTOR dependent mechanism.Graphical abstractIL-27 stimulates the activity of STAT3 and mTOR. IL-27 also enhances the interaction between STAT3 and mTOR, leading to the subsequent inhibition of ghrelin expression and appetite.
Source: Acta Pharmaceutica Sinica B - January 8, 2020 Category: Cancer & Oncology Source Type: research

Intestinal breast cancer resistance protein (BCRP) requires Janus kinase 3 activity for drug efflux and barrier functions in obesity Signal Transduction
Breast cancer resistance protein (BCRP) is a member of ATP-binding cassette (ABC) transporter proteins whose primary function is to efflux substrates bound to the plasma membrane. Impaired intestinal barrier functions play a major role in chronic low-grade inflammation (CLGI)–associated obesity, but the regulation of BCRP during obesity and its role in maintaining the intestinal barrier function during CLGI-associated obesity are unknown. In the present study, using several approaches, including efflux assays, immunoprecipitation, immunoblotting, immunohistochemistry, paracellular permeability assay, FACS, cytokine assay...
Source: Journal of Biological Chemistry - November 28, 2019 Category: Chemistry Authors: Jayshree Mishra, Randall Simonsen, Narendra Kumar Tags: Molecular Bases of Disease Source Type: research

Quercetin improves endothelial insulin sensitivity in obese mice by inhibiting Drp1 phosphorylation at serine 616 and mitochondrial fragmentation.
Abstract Studies have shown that endothelial insulin resistance induced by oxidative stress contributes to vascular dysfunction in metabolic disorders. Quercetin, a natural antioxidant, has been recently shown to exert protective effects on endothelial function. However, the effects of quercetin on endothelial insulin resistance and its underlying mechanism are unclear. Here, we found that chronic oral treatment of obese mice with quercetin increased vascular endothelial insulin sensitivity, accompanied by alleviated mitochondrial fragmentation as revealed by confocal imaging. In addition, western blot analysis sh...
Source: Acta Biochimica et Biophysica Sinica - November 27, 2019 Category: Biochemistry Authors: Chen C, Huang J, Shen J, Bai Q Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

Calcium sensing receptor activation in THP-1 macrophages triggers NLRP3 inflammasome and human preadipose cell inflammation
Publication date: Available online 15 November 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Amanda D'Espessailles, Natalia Santillana, Sofía Sanhueza, Cecilia Fuentes, Mariana CifuentesAbstractExcess adipose tissue (AT) associates with inflammation and obesity-related diseases. We studied whether calcium-sensing receptor (CaSR)-mediated NLRP3 inflammasome activation in THP-1 macrophages elevates inflammation in LS14 preadipocytes, modeling deleterious AT cell crosstalk. THP-1 macrophages exposed to Cinacalcet (CaSR activator, 2 μM, 4 h) showed elevated proinflammatory marker and NLRP3 inflammasome mRNA,...
Source: Molecular and Cellular Endocrinology - November 15, 2019 Category: Endocrinology Source Type: research

Meclofenamic acid promotes cisplatin-induced acute kidney injury by inhibiting fat mass and obesity-associated protein-mediated m6A abrogation in RNA RNA
In conclusion, reduced renal FTO expression in cisplatin-induced AKI increases RNA m6A levels and aggravates renal damages.
Source: Journal of Biological Chemistry - November 7, 2019 Category: Chemistry Authors: Peihui Zhou, Ming Wu, Chaoyang Ye, Qingqing Xu, Li Wang Tags: Molecular Bases of Disease Source Type: research