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Condition: Obesity
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Total 449 results found since Jan 2013.
STAT3 signaling promotes cardiac injury by upregulating NCOA4-mediated ferritinophagy and ferroptosis in high-fat-diet fed mice
In this study, we found that oleic acid/palmitic acid (OA/PA) increased the level of ferroptotic events including iron and ROS accumulation, upregulation of PTGS2 mRNA and protein levels, reduced SOD and GSH levels, and significant mitochondrial damage in H9C2 cells, which could be reversed by the ferroptosis inhibitor ferrostatin-1 (Fer-1). Intriguingly, we found that the autophagy inhibitor 3-methyladenine mitigated OA/PA-induced ferritin downregulation, iron overload and ferroptosis. OA/PA increased the protein level of NCOA4. Knockdown of NCOA4 by SiRNA partly reversed the reduction in ferritin, mitigated iron overload...
Source: Free Radical Biology and Medicine - March 20, 2023 Category: Biology Authors: Mengying Zhu Lulu Peng Shengqi Huo Dewei Peng Junyi Gou Wei Shi Jingwen Tao Tao Jiang Yue Jiang Qian Wang Bingyu Huang Lintong Men Sheng Li Jiagao Lv Li Lin Source Type: research
Inflammatory Cytokine Interleukin-6 (IL-6) Promotes the Proangiogenic Ability of Adipose Stem Cells from Obese Subjects < em > via < /em > the IL-6 Signaling Pathway
CONCLUSION: The finding suggests that inflammatory cytokine interleukin-6 (IL-6) promotes the proangiogenic ability of obADSCs via the IL-6 signaling pathway.PMID:36883256 | DOI:10.2174/1574888X17666220429103935
Source: Cell Research - March 8, 2023 Category: Cytology Authors: Yuanyuan Zhang Pengju Lv Yalong Li Yonghui Zhang Chaofei Cheng Hongbo Hao Han Yue Source Type: research
Oroxylin-A alleviates hepatic lipid accumulation and apoptosis under hyperlipidemic conditions via AMPK/FGF21 signaling
In conclusion, OA improves inflammation through the AMPK/FGF21 pathway, thereby attenuating lipid accumulation and apoptosis in hepatocytes. This study may help identify new targets for developing treatments for NAFLD.PMID:36736092 | DOI:10.1016/j.bbrc.2023.01.090
Source: Biochemical and Biophysical Research communications - February 3, 2023 Category: Biochemistry Authors: Wonjun Cho Sung Woo Choi Heeseung Oh A M Abd El-Aty Ahmet Hacimuftuoglu Ji Hoon Jeong Jin-Ho Song Yong Kyoo Shin Tae Woo Jung Source Type: research
GSE178987 An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis
Contributors : Batuhan Yenilmez ; Lawrence Lifshitz ; Michael Czech ; Anastasia KhvorovaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNonalcoholic steatohepatitis (NASH) is a severe liver disorder characterized by triglyceride accumulation, severe inflammation, and fibrosis. With the recent increase in prevalence, NASH is now the leading cause of liver transplantation, with no approved therapeutics available. Despite years of research, the exact molecular mechanism of NASH progression is not well understood, but fat accumulation is believed to be the primary driver of the disease. T...
Source: GEO: Gene Expression Omnibus - December 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Induction of autophagy via the PI3K/Akt/mTOR signaling pathway by Pueraria flavonoids improves non-alcoholic fatty liver disease in obese mice
Biomed Pharmacother. 2022 Nov 13;157:114005. doi: 10.1016/j.biopha.2022.114005. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is the most common among lipid metabolism disorders. Autophagy plays an important role in lipid metabolism in NAFLD. Pueraria flavonoids, the main active ingredients of Pueraria lobata, exert antioxidant and anti-inflammatory effects. Herein, we report the potential lipid-lowering and anti-inflammatory effects of Pueraria flavonoids on NAFLD induced by a high-fat diet. In vivo and in vitro experiments showed that Pueraria flavonoids reduced intracellular lipid deposition by...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 16, 2022 Category: Drugs & Pharmacology Authors: Chunbin Sun Jin Zhang Jiong Hou Menglin Hui Hualong Qi Tong Lei Xiaoshuang Zhang Luxi Zhao Hongwu Du Source Type: research
Smooth muscle cell FTO regulates contractile function
Am J Physiol Heart Circ Physiol. 2022 Oct 28. doi: 10.1152/ajpheart.00427.2022. Online ahead of print.ABSTRACTThe Fat mass and obesity gene (FTO) is a N6-methyladenosine RNA demethylase that was initially linked by GWAS studies to increased rates of obesity. Subsequent studies have revealed multiple mass-independent effects of the gene, including cardiac myocyte contractility. We created a mouse with a conditional and inducible smooth muscle cell deletion of Fto (Myh11 Cre + Ftofl/fl) and did not observe any changes in mouse body mass or mitochondrial metabolism. However, the mice had significantly decreased blood pressure...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Melissa A Luse Nenja Kr üger Miranda E Good Lauren A Biwer Vlad Serbulea Anita Salamon Rebecca A Deaton Norbert Leitinger Axel G ödecke Brant E Isakson Source Type: research
