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Condition: Obesity
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Total 449 results found since Jan 2013.
Altered fibrinogen level and fibrin clot structure in myostatin homozygous mutant pig
The objective of the present study was to explore fibrinogen levels after MSTN inhibition. Fibrinogen levels and the fibrin clot structure of MSTN homozygous knockout (KO) and wild-type (WT) pigs (n = 4 in each group) were investigated. The protein expression of fibrinogen in the serum and liver of KO pigs decreased greatly (1.6-fold loss for serum and 2.5-fold loss for liver). KO pigs showed significantly decreased gene expression of fibrinogen chains: FGA (fibrinogen-α; 11-fold), FGB (fibrinogen-β; 8-fold) and FGG (fibrinogen-γ; 7.4-fold). The basal transcriptional regulators of fibrinogen, HNF1 (hepatocyte nuclear fa...
Source: Animal Genetics - March 14, 2022 Category: Genetics & Stem Cells Authors: Hak Myong Choe Biao-Hu Quan Hyo-Jin Paek Zhao-Bo Luo Kai Gao Sheng-Zhong Han Zhou-Yan Li Jin-Dan Kang Xi-Jun Yin Source Type: research
Zinc transporter ZIP12 maintains zinc homeostasis and protects spermatogonia from oxidative stress during spermatogenesis
CONCLUSIONS: The testicular zinc transporter ZIP12 expression levels especially in spermatogonia and spermatozoa are higher than in other tissues. ZIP12 may play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis which help counteract declines in male fertility.PMID:35065654 | PMC:PMC8783530 | DOI:10.1186/s12958-022-00893-7
Source: Reproductive Biology - January 23, 2022 Category: Reproduction Medicine Authors: Xinye Zhu Chengxuan Yu Wangshu Wu Lei Shi Chenyi Jiang Li Wang Zhide Ding Yue Liu Source Type: research
Leukotriene C < sub > 4 < /sub > synthase is a novel PPAR γ target gene, and leukotriene C < sub > 4 < /sub > and D < sub > 4 < /sub > activate adipogenesis through cysteinyl LT1 receptors in adipocytes
In this study, we investigated the expression of LTC4S and production of CysLTs in murine adipocyte 3T3-L1 cells and their underlying regulatory mechanisms. Expression of LTC4S and production of LTC4 and CysLTs increased during adipogenesis, whereas siRNA-mediated suppression of LTC4S expression repressed adipogenesis by reducing adipogenic gene expression. The CysLT1 receptor, one of the two LTC4 receptors, was expressed in adipocytes. LTC4 and LTD4 increased the intracellular triglyceride levels and adipogenic gene expression, and their enhancement was suppressed by co-treatment with pranlukast, a CysLT1 receptor antagon...
Source: Biochimica et Biophysica Acta - December 30, 2021 Category: Biochemistry Authors: Ko Fujimori Saki Uno Kyohei Kuroda Chihiro Matsumoto Toko Maehara Source Type: research
Activation of the hypoxaia response pathway protects against age-induced cardiac hypertrophy
CONCLUSIONS: These results indicate that activation of the hypoxia response pathway upregulates Notch signaling and its target Hey2 resulting in transcriptional repression of hypertrophy-associated genes and less cardiomyocyte hypertrophy. This is eventually associated with better preserved cardiac function upon aging. Activation of the hypoxia response pathway thus has therapeutic potential for combating age-induced cardiac hypertrophy.PMID:34919895 | DOI:10.1016/j.yjmcc.2021.12.003
Source: Atherosclerosis - December 17, 2021 Category: Cardiology Authors: Tapio R öning Johanna Magga Anna Laitakari Riikka Halmetoja Joona Tapio Elitsa Y Dimova Zoltan Szabo Lea Rahtu-Korpela Anna Kemppi Gail Walkinshaw Johanna Myllyharju Risto Kerkel ä Peppi Koivunen Raisa Serpi Source Type: research
Leptin enhances hepatic fibrosis and inflammation in a mouse model of cholestasis
Am J Pathol. 2021 Dec 8:S0002-9440(21)00523-X. doi: 10.1016/j.ajpath.2021.11.008. Online ahead of print.ABSTRACTLeptin is an adipokine with roles in food intake and energy metabolism through its actions on neurons in the hypothalamus. The role of leptin in obesity and cardiovascular disorders is well documented; however, its influence on liver conditions such as cholestasis is poorly understood. The effects of exogenous leptin and leptin-neutralizing antibody (Leptin-Ab) on biliary hyperplasia, hepatic fibrosis and inflammation in the multidrug resistance protein 2 knockout (Mdr2KO) mouse model of cholestasis were assessed...
Source: Am J Pathol - December 13, 2021 Category: Pathology Authors: Anca D Petrescu Stephanie Grant Elaina Williams Su Yeon An Nikhil Seth Mark Shell Tyson Amundsen Christopher Tan Yusra Nadeem Matthew Tjahja Lancaster Weld Christopher S Chu Julie Venter Gabriel Frampton Matthew McMillin Sharon DeMorrow Source Type: research
