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Condition: Obesity
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Total 449 results found since Jan 2013.
3-hydroxymorphinan enhances mitochondrial biogenesis and adipocyte browning through AMPK-dependent pathway
Biochem Biophys Res Commun. 2021 Aug 30;577:17-23. doi: 10.1016/j.bbrc.2021.08.083. Online ahead of print.ABSTRACT3-hydroxymorphinan (3-HM), a metabolite of dextromethorphan, has previously been reported to have anti-inflammatory, anti-oxidative stress, and neuroprotective effects. However, its effect on energy metabolism in adipocytes remains unclear. Herein, we investigated 3-hydroxymorphinan (3-HM) effects on mitochondrial biogenesis, oxidative stress, and lipid accumulation in 3T3-L1 adipocytes. Further, we explored 3-HM-associated molecular mechanisms. Mouse adipocyte 3T3-L1 cells were treated with 3-HM, and various p...
Source: Biochemical and Biophysical Research communications - September 6, 2021 Category: Biochemistry Authors: Tae Woo Jung Eui Jin Hwang Do Hyeon Pyun Tae Jin Kim Hyun Jung Lee A M Abd El-Aty Joon Seok Bang Hyoung-Chun Kim Ji Hoon Jeong Source Type: research
Pituitary P62 deficiency leads to female infertility by impairing luteinizing hormone production
Exp Mol Med. 2021 Aug 27. doi: 10.1038/s12276-021-00661-4. Online ahead of print.ABSTRACTP62 is a protein adaptor for various metabolic processes. Mice that lack p62 develop adult-onset obesity. However, investigations on p62 in reproductive dysfunction are rare. In the present study, we explored the effect of p62 on the reproductive system. P62 deficiency-induced reproductive dysfunction occurred at a young age (8 week old). Young systemic p62 knockout (p62-/-) and pituitary-specific p62 knockout (p62flox/flox αGSUcre) mice both presented a normal metabolic state, whereas they displayed infertility phenotypes (attenuated...
Source: Molecular Medicine - August 28, 2021 Category: Molecular Biology Authors: Xing Li Ling Zhou Guiliang Peng Mingyu Liao Linlin Zhang Hua Hu Ling Long Xuefeng Tang Hua Qu Jiaqing Shao Hongting Zheng Min Long Source Type: research
Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes
In conclusion, Grp75 or Mfn2 silencing and overexpression in Huh7 cells contribute to altering MAM integrity and cholesterol storage in opposite directions, but all promote triglyceride accumulation through distinct cellular pathways. This study also highlights that besides Mfn2, Grp75 could play a central role in hepatic lipid and cholesterol metabolism in obesity and NAFLD.PMID:34419589 | DOI:10.1016/j.bbalip.2021.159030
Source: Mol Biol Cell - August 22, 2021 Category: Molecular Biology Authors: Arthur Bassot Carina Prip Buus Ana ïs Alves Olivier Berdeaux Johan Perrier V éronique Lenoir Jingwei Ji-Cao Marie-Agn ès Berger Emmanuelle Loizon Stephanie Cabaret Baptiste Panthu Jennifer Rieusset B éatrice Morio Source Type: research
Loss of lymphocyte cytosolic protein 1 (LCP1) induces browning in 3T3-L1 adipocytes via β3-AR and the ERK-independent signaling pathway
Int J Biochem Cell Biol. 2021 Aug 6:106053. doi: 10.1016/j.biocel.2021.106053. Online ahead of print.ABSTRACTIncreased browning of white adipocytes (beiging) is considered a promising therapeutic strategy to fight obesity and its associated metabolic complications. However, the molecular mechanism modulating brown and beige fat-mediated thermogenesis is not fully elucidated. Here, we identified the lymphocyte cytosolic protein 1 (LCP1) as a factor that obstructs fat browning in white adipocytes. LCP1 plays a vital role in non-hematopoietic malignancies, and is also a well-known tumor biomarker; however, evidence regarding ...
Source: The International Journal of Biochemistry and Cell Biology - August 9, 2021 Category: Biochemistry Authors: Subramani Manigandan Jong Won Yun Source Type: research
HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling
Conclusions/interpretationIn summary, our study identifies HAND2 as a novel obesity-linked adipocyte transcription factor, highlighting new mechanisms of GR-dependent adipogenesis in humans and mice.Data availabilityArray data have been submitted to the GEO database at NCBI (GSE148699).Graphical abstract
Source: Diabetologia - August 1, 2021 Category: Endocrinology Source Type: research
Silencing of RSPO1 mitigates obesity-related renal fibrosis in mice by deactivating Wnt/ β-catenin pathway
Exp Cell Res. 2021 Jun 25:112713. doi: 10.1016/j.yexcr.2021.112713. Online ahead of print.ABSTRACTObesity, a global epidemic, is one of the critical causes of chronic kidney disease (CKD). R-spondin1 (RSPO1) possessing the potential to activate Wnt/β-catenin pathway was reported to be elevated in circulation of obesity objects. However, the function of RSPO1 and the latent mechanism in obesity-related CKD are still left to be revealed. In the present study, renal RSPO1 expression was increased in mice fed on high-fat diet (HFD) for 12 weeks. Lentivirus-mediated RSPO1 knockdown partly recovered obesity-related metabolic sy...
Source: Experimental Cell Research - June 28, 2021 Category: Cytology Authors: Xuesong Su Guangyu Zhou Mi Tian Si Wu Yanqiu Wang Source Type: research
